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26:
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Kleyn, P. W.; Fan, W.; Kovats, S. G.; Lee, J. J.; Pulido, J. C.; Wu, Y.; Berkemeier, L. R.; Misumi, D. J.; Holmgren, L.; Charlat, O.; Woolf, E. A.; Tayber, O.; Brody, T.; Shu, P.; Hawkins, F.; Kennedy, B.; Baldini, L.; Ebeling, C.; Alperin, G. D.; Deeds, J.; Lakey, N. D.; Culpepper, J.; Chen, H.;
161:
869:
630:
Boggon, TJ; Shan, WS; Santagata, S; Myers, SC; Shapiro, L (1999). "Implication of tubby proteins as transcription factors by structure-based functional analysis".
117:
105:
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Ohlemiller, KK; Hughes, RM; Mosinger-Ogilvie, J; Speck, JD; Grosof, DH; Silverman, MS (1995). "Cochlear and retinal degeneration in the tubby mouse".
893:
85:
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in the central pore. The gene derives its name from its role in metabolism; mice with a mutated tubby gene develop delayed-onset
898:
855:
181:
580:"Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors"
434:
Noben-Trauth, K.; Naggert, J. K.; North, M. A.; Nishina, P. M. (1996). "A candidate gene for the mouse mutation tubby".
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Cho, W. & Stahelin, R.V. (June 2005). "Membrane-protein interactions in cell signaling and membrane trafficking".
888:
330:
287:
169:
334:
165:
750:
488:"Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family"
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to tubby are known as "tubby-like proteins" (TULPs). They share a common and characteristic
835:
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Wang, Y; Seburn, K; Bechtel, L; Lee, BY; Szatkiewicz, JP; Nishina, PM; Naggert, JK (2006).
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110:
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710:"C. elegans tubby regulates life span and fat storage by two independent mechanisms"
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521:
54:
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564:
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366:
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144:
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306:. A similar structural fold to the Tubby like proteins has been identified in the
122:
66:
275:
263:
259:
726:
709:
25:
665:
Carroll, K; Gomez, C; Shapiro, L (2004). "Tubby proteins: the plot thickens".
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369:
307:
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225:
751:"Defective carbohydrate metabolism in mice homozygous for the tubby mutation"
578:
Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Söding J (January 2009).
323:
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barrel surrounding a central alpha helix. Tubby proteins can bind the small
239:
809:
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735:
686:
651:
613:
556:
513:
486:
Glücksmann-Kuis, M. A.; Carlson, G. A.; Duyk, G. M.; Moore, K. J. (1996).
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Mukhopadhyay, A; Deplancke, B; Walhout, AJ; Tissenbaum, HA (2005).
391:
247:
138:
49:
362:
357:. In mice, mutations in tubby proteins are known to affect
843:
790:
Annual Review of
Biophysics and Biomolecular Structure
372:. Tubby domains associate with cytoplasmic side of
187:
175:
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137:
132:
116:
104:
84:
72:
60:
48:
40:
35:
18:
341:are implicated in three disease processes when
322:and as potential signaling factors coupled to
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8:
870:
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129:
725:
603:
503:
802:10.1146/annurev.biophys.33.110502.133337
625:
623:
30:A tubby protein expressed in mouse brain
426:
318:Tubby proteins have been implicated as
302:, which is typically localized to the
15:
383:Human proteins containing this domain
7:
824:
822:
326:activity. They are associated with
842:. You can help Knowledge (XXG) by
767:10.1152/physiolgenomics.00239.2005
14:
286:Tubby proteins are classified as
826:
549:10.1097/00001756-199504190-00005
24:
1:
644:10.1126/science.286.5447.2119
596:10.1093/bioinformatics/btn595
505:10.1016/S0092-8674(00)81104-6
376:through binding of different
133:Available protein structures:
894:Peripheral membrane proteins
915:
821:
727:10.1016/j.cmet.2005.06.004
128:
23:
250:, and proteins that are
238:common to multicellular
290:proteins and have a 12-
246:gene was identified in
899:Membrane protein stubs
838:–related article is a
667:Nat Rev Mol Cell Biol
320:transcription factors
231:. It is an upstream
310:family of proteins.
300:phosphatidylinositol
276:retinal degeneration
448:1996Natur.380..534N
365:storage as well as
258:that consists of a
353:degeneration, and
256:tertiary structure
224:is encoded by the
851:
850:
638:(5447): 2119–25.
442:(6574): 534–538.
378:phosphoinositides
262:packed around an
218:
217:
214:
213:
182:structure summary
906:
872:
865:
858:
836:membrane protein
830:
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755:Physiol Genomics
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456:10.1038/380534a0
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270:, sensorineural
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28:
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889:Protein domains
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416:SCOP tubby fold
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331:differentiation
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106:OPM superfamily
31:
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5:
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584:Bioinformatics
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498:(2): 281–290.
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410:External links
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374:cell membranes
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296:cell signaling
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761:(2): 131–40.
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304:cell membrane
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292:beta stranded
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19:Tubby Protein
17:
844:expanding it
833:
818:
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789:
783:
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744:
720:(1): 35–42.
717:
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673:(1): 55–63.
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631:
587:
583:
573:
543:(6): 845–9.
540:
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386:
367:carbohydrate
355:hearing loss
317:
285:
272:hearing loss
243:
242:. The first
226:
221:
219:
204:A:257-499
198:A:258-500
796:: 119–151.
537:NeuroReport
335:development
264:alpha helix
260:beta barrel
118:OPM protein
36:Identifiers
883:Categories
714:Cell Metab
422:References
370:metabolism
308:Scramblase
252:homologous
240:eukaryotes
145:structures
359:life span
337:, and in
324:G-protein
298:molecule
282:Structure
210:A:257-499
79:PDOC00923
67:IPR000007
810:15869386
775:16849632
736:16054097
687:14708010
652:10591637
614:19010806
522:15670925
390:;
328:neuronal
314:Function
162:RCSB PDB
62:InterPro
695:7065010
632:Science
605:2639001
565:8311280
557:7612867
514:8612280
472:4272027
464:8606774
444:Bibcode
351:retinal
347:obesity
343:mutated
339:mammals
268:obesity
236:protein
74:PROSITE
55:PF01167
808:
773:
734:
693:
685:
650:
612:
602:
563:
555:
520:
512:
470:
462:
436:Nature
402:;
398:;
394:;
274:, and
177:PDBsum
151:
141:
99:SUPFAM
41:Symbol
834:This
691:S2CID
561:S2CID
518:S2CID
468:S2CID
404:TULP4
400:TULP3
396:TULP2
392:TULP1
244:tubby
95:SCOPe
86:SCOP2
840:stub
806:PMID
771:PMID
732:PMID
683:PMID
648:PMID
610:PMID
553:PMID
510:PMID
492:Cell
460:PMID
361:and
333:and
248:mice
229:gene
220:The
207:1c8z
201:1i7e
195:1s31
170:PDBj
166:PDBe
149:ECOD
139:Pfam
123:1i7e
91:1c8z
50:Pfam
798:doi
763:doi
722:doi
675:doi
640:doi
636:286
600:PMC
592:doi
545:doi
500:doi
452:doi
440:380
388:TUB
363:fat
288:α+β
227:TUB
189:PDB
157:PDB
111:104
44:Tub
885::
804:.
794:34
792:.
769:.
759:27
757:.
753:.
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622:^
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588:25
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406:;
349:,
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97:/
93:/
871:e
864:t
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724::
718:2
697:.
677::
671:5
654:.
642::
616:.
594::
567:.
547::
541:6
524:.
502::
474:.
454::
446::
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