115:
172:
Type IIB keratins are a group of intermediate filament proteins that are primarily expressed in epithelial tissues, such as the skin, nails, and hair follicles. They belong to the keratin family of proteins, which are characterized by their highly conserved alpha-helical coiled-coil domains. Keratin
151:
Type IIA keratins have a unique structural feature that allows them to form coiled-coil dimers, which then assemble into tetramers and eventually into intermediate filaments. This structural organization provides the mechanical strength and resilience necessary to withstand the stresses experienced
105:
Type II Keratins are divided into 2 subtypes: Type IIA Keratins and Type IIB Keratins. Type 2A keratins are expressed in tissues that require high levels of mechanical stress, such as the soles of the feet, while type 2B keratins are expressed in tissues that are subject to less stress, such as the
181:
that assemble into intermediate filaments, which provide mechanical stability and resistance to mechanical stress. In addition to their structural role, type IIB keratins have been shown to play important roles in wound healing, inflammation, and cell migration. Dysregulation of type IIB keratin
118:
From
Uniprot. Figure shows the structure of KRT1 gene. The helix is formed by the type II keratins in green, and the type I keratins in grey. The green coils consists of type IIA and IIB keratins. Expressed in upper leg skin, mammalian vulva, upper arm skin and 106 other tissues. Located on
46:
are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues. It has been seen that Type II Keratins are developed before Type 1 keratins during human embryonic development.
123:
Type IIA Keratins are characterized by their expression in tissues that undergo high stress, like soles of the feet or palms of the hand. There are several different type 2A keratins that have been identified in humans, including
214:
Schweizer, JĂĽrgen; Bowden, Paul E.; Coulombe, Pierre A.; Langbein, Lutz; Lane, E. Birgitte; Magin, Thomas M.; Maltais, Lois; Omary, M. Bishr; Parry, David A.D.; Rogers, Michael A.; Wright, Mathew W. (17 July 2006).
148:. These keratins are expressed in a tissue-specific manner, with K1, K2, and K10 being predominantly expressed in the epidermis, while K9, K77, and K78 are expressed in the nail bed and hair follicles.
639:
256:
38:(IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. The type 2 cytokeratins consist of basic or neutral, high molecular weight
182:
expression or mutations in the KRT6B gene have been associated with a variety of skin disorders, including psoriasis, epidermolysis bullosa, and pachyonychia congenita.
602:
701:
3028:
177:
gene and is often co-expressed with the equivalent keratin type IIA (KRT6A) in a variety of epithelial tissues. Together, these two proteins form
1329:
617:
3676:
694:
216:
89:
Overall, keratin type 2 plays a crucial role in maintaining the strength and integrity of the skin, hair, and nails. Mutations in
491:
Chamcheu, Jean
Christopher; Siddiqui, Imtiaz A.; Syed, Deeba N.; Adhami, Vaqar M.; Liovic, Mirjana; Mukhtar, Hasan (2011-04-15).
1848:
152:
by the tissues in which they are expressed. Mutations in type 2A keratin genes can lead to various genetic disorders, such as
3686:
3021:
2117:
1960:
687:
3408:
3312:
3287:
2996:
2550:
94:
3440:
3369:
3307:
3302:
153:
3358:
3317:
3204:
3199:
3194:
3188:
3107:
1257:
3396:
3332:
3275:
3247:
3237:
3167:
3100:
2728:
3385:
3120:
3082:
3014:
2961:
668:
436:"Human keratin diseases: the increasing spectrum of disease and subtlety of the phenotype-genotype correlation"
157:
622:
221:
114:
618:"Function of type I and type II keratin head domains: their role in dimer, tetramer and filament formation"
35:
3454:
1380:
734:
596:
410:
3049:
1649:
3281:
2956:
1589:
3620:
3431:
1409:
1039:
473:
3707:
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2807:
2510:
1171:
584:
530:
512:
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457:
367:
349:
307:
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248:
2530:
97:, a rare condition characterized by blistering and erosion of the skin and mucous membranes.
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3231:
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1997:
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357:
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238:
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841:
821:
664:
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3528:
3523:
3518:
3114:
3076:
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1361:
1244:
1064:
3158:
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2723:
1420:
1251:
760:
579:
554:
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362:
243:
191:
161:
3701:
3459:
3041:
2924:
2919:
1884:
1754:
1703:
1653:
1593:
1515:
1483:
1424:
1210:
729:
452:
435:
51:
477:
3583:
2768:
1823:
1578:
1122:
714:
178:
17:
2740:
2718:
3661:
3590:
3326:
3271:
2914:
2865:
2735:
2625:
1955:
1399:
1354:
1273:
1195:
743:
674:
570:
679:
295:
93:
genes can lead to various genetic disorders that affect these tissues, such as
3292:
2966:
2885:
2875:
2763:
1874:
1853:
1619:
1556:
1551:
1546:
1526:
1501:
1489:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1297:
1179:
1168:
1154:
770:
553:
Justin T. Jacob, Pierre A. Coulombe, Raymond Kwan, and M. Bishr Omary (2018).
508:
345:
137:
516:
461:
353:
303:
280:"Type II keratins precede type I keratins during early embryonic development"
2795:
2790:
2785:
2745:
2583:
2578:
2573:
1931:
1911:
1566:
1561:
1541:
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1334:
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329:
279:
133:
63:
59:
55:
635:
588:
534:
469:
371:
311:
278:
Lu, Hong; Hesse, Michael; Peters, Bettina; Magin, Thomas M. (August 2005).
252:
3006:
234:
3444:
3423:
3060:
2909:
2870:
2802:
2775:
2642:
2630:
2505:
2500:
1941:
1936:
1858:
1292:
1287:
1149:
385:
3666:
3657:
3605:
3578:
3473:
3449:
3413:
3401:
3219:
3214:
3209:
3137:
3037:
2936:
2890:
2780:
2710:
2679:
2609:
2604:
2568:
2563:
2558:
2525:
2495:
2490:
2485:
2480:
2165:
2097:
2092:
2087:
2082:
2077:
1969:
1906:
1394:
1339:
1280:
1263:
1224:
710:
90:
39:
493:"Keratin Gene Mutations in Disorders of Human Skin and its Appendages"
3610:
3374:
3347:
3342:
3337:
3262:
3257:
3252:
3242:
3177:
3172:
3130:
3125:
3087:
2855:
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2515:
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2313:
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2283:
2273:
2258:
2253:
2135:
2130:
2125:
2037:
2027:
2007:
1992:
1987:
1982:
1977:
1843:
1614:
1609:
1366:
1032:
1027:
1017:
795:
86:. Their molecular weight ranges from 52 kDa (CK8) to 67 kDa (CK18).
3635:
3630:
3600:
3595:
3573:
3555:
3533:
3142:
2880:
2652:
2635:
2472:
2467:
2457:
2452:
2417:
2407:
2397:
2382:
2363:
2353:
2348:
2333:
2328:
2323:
2318:
2293:
2278:
2268:
2263:
2248:
2243:
2223:
2218:
2213:
2208:
2203:
2198:
2193:
2188:
2183:
2178:
2173:
2145:
2140:
2107:
2102:
2072:
2067:
2047:
2042:
2022:
2012:
1927:
1805:
1800:
1795:
1790:
1785:
1780:
1775:
1770:
1765:
1760:
1744:
1739:
1734:
1729:
1724:
1719:
1714:
1709:
1684:
1679:
1674:
1669:
1664:
1659:
1639:
1634:
1629:
1624:
1604:
1599:
1309:
1239:
1188:
1185:
1182:
1174:
1163:
1160:
1157:
1142:
1137:
1132:
1127:
1099:
1089:
1074:
1007:
997:
977:
952:
947:
932:
922:
917:
912:
907:
902:
897:
882:
836:
831:
826:
816:
811:
806:
785:
780:
775:
765:
752:
174:
145:
141:
113:
3615:
2981:
2976:
2971:
2931:
2902:
2817:
2694:
2689:
2684:
2588:
2238:
2233:
2228:
2155:
2150:
2017:
1899:
1894:
1889:
1349:
1344:
1302:
1215:
1205:
1200:
1094:
1084:
1079:
1069:
1059:
1054:
1049:
1044:
967:
892:
887:
877:
872:
867:
862:
857:
852:
129:
125:
3010:
683:
83:
79:
75:
71:
67:
119:
Chromosome 12, localized in the cell membrane and cytoplasm.
328:
Moll, Roland; Divo, Markus; Langbein, Lutz (2008-06-01).
3650:
3566:
3472:
3422:
3151:
3068:
3059:
3048:
2949:
2848:
2754:
2709:
2618:
2597:
2549:
2372:
2164:
2116:
1968:
1954:
1920:
1867:
1836:
1816:
1695:
1577:
1408:
1390:
1379:
1322:
1115:
794:
751:
742:
728:
721:
217:"New consensus nomenclature for mammalian keratins"
164:and blistering of the skin on the palms and soles.
555:"Types I and II Keratin Intermediate Filaments"
3022:
695:
8:
601:: CS1 maint: multiple names: authors list (
330:"The human keratins: biology and pathology"
3065:
3056:
3029:
3015:
3007:
1965:
1405:
1387:
748:
739:
725:
702:
688:
680:
559:Cold Spring Harbor Perspectives in Biology
667:at the U.S. National Library of Medicine
578:
524:
451:
434:Irvine, A. D.; McLean, W. H. (May 1999).
361:
242:
616:Hatzfeld, M.; Burba, M. (1 July 1994).
497:Archives of Biochemistry and Biophysics
203:
594:
7:
548:
546:
544:
323:
321:
209:
207:
50:Type II cytokeratins are encoded on
3677:Cartilage oligomeric matrix protein
440:The British Journal of Dermatology
160:(PPK), which are characterized by
25:
1330:Wiskott–Aldrich syndrome protein
453:10.1046/j.1365-2133.1999.02810.x
284:European Journal of Cell Biology
2551:Microtubule organising proteins
642:from the original on 2022-08-04
334:Histochemistry and Cell Biology
259:from the original on 2020-02-11
1:
2598:Microtubule severing proteins
95:epidermolysis bullosa simplex
3441:Cartilage associated protein
1258:actin depolymerizing factors
675:Proteopedia page on keratins
154:epidermolytic hyperkeratosis
2736:Plakoglobin (gamma catenin)
571:10.1101/cshperspect.a018275
173:type IIB is encoded by the
3724:
386:"KRT1 expression in human"
296:10.1016/j.ejcb.2005.04.001
101:Keratin 2 Types: 2A and 2B
34:) constitutes the Type II
2992:
509:10.1016/j.abb.2010.12.019
346:10.1007/s00418-008-0435-6
2962:Prokaryotic cytoskeleton
669:Medical Subject Headings
158:palmoplantar keratoderma
623:Journal of Cell Science
222:Journal of Cell Biology
636:10.1242/jcs.107.7.1959
120:
36:intermediate filaments
3455:Procollagen peptidase
1582:(hard alpha-keratins)
1413:(soft alpha-keratins)
235:10.1083/jcb.200603161
117:
2997:cytoskeletal defects
2957:Major sperm proteins
106:palms of the hands.
32:Type II cytokeratins
1410:Epithelial keratins
18:Type II cytokeratin
3621:Matrix gla protein
3432:Prolyl hydroxylase
121:
3695:
3694:
3646:
3645:
3468:
3467:
3436:Lysyl hydroxylase
3227:basement membrane
3004:
3003:
2945:
2944:
2705:
2704:
1950:
1949:
1832:
1831:
1375:
1374:
1318:
1317:
168:Type IIB Keratins
110:Type IIA Keratins
54:and encompasses:
16:(Redirected from
3715:
3066:
3057:
3031:
3024:
3017:
3008:
1966:
1406:
1388:
749:
740:
726:
704:
697:
690:
681:
652:
651:
649:
647:
630:(7): 1959–1972.
613:
607:
606:
600:
592:
582:
550:
539:
538:
528:
488:
482:
481:
455:
431:
425:
424:
422:
421:
407:
401:
400:
398:
396:
382:
376:
375:
365:
325:
316:
315:
275:
269:
268:
266:
264:
246:
211:
28:Type II keratins
21:
3723:
3722:
3718:
3717:
3716:
3714:
3713:
3712:
3698:
3697:
3696:
3691:
3642:
3562:
3464:
3418:
3301:transmembrane:
3147:
3051:
3044:
3035:
3005:
3000:
2988:
2941:
2844:
2750:
2701:
2614:
2593:
2545:
2368:
2160:
2112:
1958:
1946:
1916:
1863:
1828:
1812:
1696:Ungrouped alpha
1691:
1581:
1573:
1412:
1398:
1392:
1382:
1371:
1314:
1111:
790:
732:
717:
708:
665:Type+II+Keratin
661:
656:
655:
645:
643:
615:
614:
610:
593:
552:
551:
542:
490:
489:
485:
433:
432:
428:
419:
417:
415:www.uniprot.org
409:
408:
404:
394:
392:
384:
383:
379:
327:
326:
319:
277:
276:
272:
262:
260:
213:
212:
205:
200:
188:
170:
112:
103:
23:
22:
15:
12:
11:
5:
3721:
3719:
3711:
3710:
3700:
3699:
3693:
3692:
3690:
3689:
3684:
3680:
3679:
3674:
3669:
3664:
3654:
3652:
3648:
3647:
3644:
3643:
3641:
3640:
3639:
3638:
3633:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3587:
3586:
3576:
3570:
3568:
3564:
3563:
3561:
3560:
3559:
3558:
3553:
3548:
3538:
3537:
3536:
3531:
3526:
3521:
3511:
3510:
3509:
3504:
3499:
3494:
3489:
3478:
3476:
3470:
3469:
3466:
3465:
3463:
3462:
3457:
3452:
3447:
3438:
3428:
3426:
3420:
3419:
3417:
3416:
3411:
3406:
3405:
3404:
3399:
3389:
3379:
3378:
3377:
3372:
3362:
3352:
3351:
3350:
3345:
3340:
3335:
3321:
3320:
3315:
3310:
3305:
3298:
3297:
3296:
3295:
3290:
3278:
3268:
3267:
3266:
3265:
3260:
3255:
3250:
3245:
3240:
3223:
3222:
3217:
3212:
3207:
3202:
3197:
3192:
3182:
3181:
3180:
3175:
3170:
3155:
3153:
3149:
3148:
3146:
3145:
3140:
3135:
3134:
3133:
3128:
3123:
3111:
3104:
3092:
3091:
3090:
3085:
3072:
3070:
3069:Fibril forming
3063:
3054:
3050:Extracellular
3046:
3045:
3042:scleroproteins
3036:
3034:
3033:
3026:
3019:
3011:
3002:
3001:
2993:
2990:
2989:
2987:
2986:
2985:
2984:
2979:
2974:
2969:
2959:
2953:
2951:
2947:
2946:
2943:
2942:
2940:
2939:
2934:
2929:
2928:
2927:
2922:
2912:
2907:
2906:
2905:
2895:
2894:
2893:
2888:
2883:
2878:
2873:
2868:
2863:
2861:Corneodesmosin
2852:
2850:
2846:
2845:
2843:
2842:
2841:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2800:
2799:
2798:
2793:
2788:
2778:
2773:
2772:
2771:
2760:
2758:
2752:
2751:
2749:
2748:
2743:
2738:
2733:
2732:
2731:
2721:
2715:
2713:
2707:
2706:
2703:
2702:
2700:
2699:
2698:
2697:
2692:
2687:
2677:
2676:
2675:
2670:
2665:
2660:
2655:
2645:
2640:
2639:
2638:
2628:
2622:
2620:
2616:
2615:
2613:
2612:
2607:
2601:
2599:
2595:
2594:
2592:
2591:
2586:
2581:
2576:
2571:
2566:
2561:
2555:
2553:
2547:
2546:
2544:
2543:
2538:
2533:
2528:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2483:
2476:
2475:
2470:
2465:
2460:
2455:
2450:
2445:
2440:
2435:
2430:
2425:
2420:
2415:
2410:
2405:
2400:
2395:
2390:
2385:
2378:
2376:
2370:
2369:
2367:
2366:
2361:
2356:
2351:
2346:
2341:
2336:
2331:
2326:
2321:
2316:
2311:
2306:
2301:
2296:
2291:
2286:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2226:
2221:
2216:
2211:
2206:
2201:
2196:
2191:
2186:
2181:
2176:
2170:
2168:
2162:
2161:
2159:
2158:
2153:
2148:
2143:
2138:
2133:
2128:
2122:
2120:
2114:
2113:
2111:
2110:
2105:
2100:
2095:
2090:
2085:
2080:
2075:
2070:
2065:
2060:
2055:
2050:
2045:
2040:
2035:
2030:
2025:
2020:
2015:
2010:
2005:
2000:
1995:
1990:
1985:
1980:
1974:
1972:
1963:
1952:
1951:
1948:
1947:
1945:
1944:
1939:
1934:
1928:Nuclear lamins
1924:
1922:
1918:
1917:
1915:
1914:
1909:
1904:
1903:
1902:
1897:
1892:
1882:
1877:
1871:
1869:
1865:
1864:
1862:
1861:
1856:
1851:
1846:
1840:
1838:
1834:
1833:
1830:
1829:
1827:
1826:
1820:
1818:
1814:
1813:
1811:
1810:
1809:
1808:
1803:
1798:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1750:
1749:
1748:
1747:
1742:
1737:
1732:
1727:
1722:
1717:
1712:
1699:
1697:
1693:
1692:
1690:
1689:
1688:
1687:
1682:
1677:
1672:
1667:
1662:
1645:
1644:
1643:
1642:
1637:
1632:
1627:
1622:
1617:
1612:
1607:
1602:
1585:
1583:
1575:
1574:
1572:
1571:
1570:
1569:
1564:
1559:
1554:
1549:
1544:
1539:
1534:
1529:
1524:
1507:
1506:
1505:
1504:
1494:
1493:
1492:
1480:
1479:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1416:
1414:
1403:
1385:
1377:
1376:
1373:
1372:
1370:
1369:
1364:
1359:
1358:
1357:
1352:
1347:
1337:
1332:
1326:
1324:
1320:
1319:
1316:
1315:
1313:
1312:
1307:
1306:
1305:
1300:
1290:
1285:
1284:
1283:
1278:
1277:
1276:
1271:
1254:
1252:Arp2/3 complex
1249:
1248:
1247:
1242:
1237:
1232:
1221:
1220:
1219:
1218:
1213:
1208:
1203:
1193:
1192:
1191:
1177:
1166:
1147:
1146:
1145:
1140:
1135:
1130:
1119:
1117:
1113:
1112:
1110:
1109:
1108:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1037:
1036:
1035:
1030:
1022:
1021:
1020:
1012:
1011:
1010:
1002:
1001:
1000:
995:
987:
986:
985:
980:
972:
971:
970:
962:
961:
960:
955:
950:
942:
941:
940:
935:
927:
926:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
847:
846:
845:
839:
834:
829:
824:
819:
814:
809:
800:
798:
792:
791:
789:
788:
783:
778:
773:
768:
763:
757:
755:
746:
737:
730:Microfilaments
723:
719:
718:
709:
707:
706:
699:
692:
684:
678:
677:
672:
660:
659:External links
657:
654:
653:
608:
565:(4): a018275.
540:
503:(2): 123–137.
483:
446:(5): 815–828.
426:
402:
377:
340:(6): 705–733.
317:
290:(8): 709–718.
270:
229:(2): 169–174.
202:
201:
199:
196:
195:
194:
192:Type I keratin
187:
184:
169:
166:
162:hyperkeratosis
111:
108:
102:
99:
52:chromosome 12q
24:
14:
13:
10:
9:
6:
4:
3:
2:
3720:
3709:
3706:
3705:
3703:
3688:
3685:
3682:
3681:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3659:
3656:
3655:
3653:
3649:
3637:
3634:
3632:
3629:
3628:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3585:
3582:
3581:
3580:
3577:
3575:
3572:
3571:
3569:
3565:
3557:
3554:
3552:
3549:
3547:
3544:
3543:
3542:
3539:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3516:
3515:
3512:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3484:
3483:
3480:
3479:
3477:
3475:
3471:
3461:
3460:Lysyl oxidase
3458:
3456:
3453:
3451:
3448:
3446:
3442:
3439:
3437:
3433:
3430:
3429:
3427:
3425:
3421:
3415:
3412:
3410:
3407:
3403:
3400:
3398:
3395:
3394:
3393:
3390:
3387:
3383:
3380:
3376:
3373:
3371:
3368:
3367:
3366:
3363:
3360:
3356:
3353:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3330:
3329:
3328:
3323:
3322:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3300:
3299:
3294:
3291:
3289:
3286:
3285:
3284:
3283:
3279:
3277:
3273:
3270:
3269:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3235:
3234:
3233:
3228:
3225:
3224:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3201:
3198:
3196:
3193:
3190:
3186:
3183:
3179:
3176:
3174:
3171:
3169:
3166:
3165:
3164:
3160:
3157:
3156:
3154:
3150:
3144:
3141:
3139:
3136:
3132:
3129:
3127:
3124:
3122:
3119:
3118:
3117:
3116:
3112:
3110:
3109:
3105:
3102:
3098:
3097:
3093:
3089:
3086:
3084:
3081:
3080:
3079:
3078:
3074:
3073:
3071:
3067:
3064:
3062:
3058:
3055:
3053:
3047:
3043:
3039:
3032:
3027:
3025:
3020:
3018:
3013:
3012:
3009:
2999:
2998:
2991:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2964:
2963:
2960:
2958:
2955:
2954:
2952:
2948:
2938:
2935:
2933:
2930:
2926:
2923:
2921:
2918:
2917:
2916:
2913:
2911:
2908:
2904:
2901:
2900:
2899:
2896:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2858:
2857:
2854:
2853:
2851:
2847:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2805:
2804:
2801:
2797:
2794:
2792:
2789:
2787:
2784:
2783:
2782:
2779:
2777:
2774:
2770:
2767:
2766:
2765:
2762:
2761:
2759:
2757:
2753:
2747:
2744:
2742:
2741:Delta catenin
2739:
2737:
2734:
2730:
2727:
2726:
2725:
2722:
2720:
2719:Alpha catenin
2717:
2716:
2714:
2712:
2708:
2696:
2693:
2691:
2688:
2686:
2683:
2682:
2681:
2678:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2650:
2649:
2646:
2644:
2641:
2637:
2634:
2633:
2632:
2629:
2627:
2624:
2623:
2621:
2617:
2611:
2608:
2606:
2603:
2602:
2600:
2596:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2570:
2567:
2565:
2562:
2560:
2557:
2556:
2554:
2552:
2548:
2542:
2539:
2537:
2534:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:cytoplasmic:
2478:
2477:
2474:
2471:
2469:
2466:
2464:
2461:
2459:
2456:
2454:
2451:
2449:
2446:
2444:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2399:
2396:
2394:
2391:
2389:
2386:
2384:
2380:
2379:
2377:
2375:
2371:
2365:
2362:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2307:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2227:
2225:
2222:
2220:
2217:
2215:
2212:
2210:
2207:
2205:
2202:
2200:
2197:
2195:
2192:
2190:
2187:
2185:
2182:
2180:
2177:
2175:
2172:
2171:
2169:
2167:
2163:
2157:
2154:
2152:
2149:
2147:
2144:
2142:
2139:
2137:
2134:
2132:
2129:
2127:
2124:
2123:
2121:
2119:
2115:
2109:
2106:
2104:
2101:
2099:
2096:
2094:
2091:
2089:
2086:
2084:
2081:
2079:
2076:
2074:
2071:
2069:
2066:
2064:
2061:
2059:
2056:
2054:
2051:
2049:
2046:
2044:
2041:
2039:
2036:
2034:
2031:
2029:
2026:
2024:
2021:
2019:
2016:
2014:
2011:
2009:
2006:
2004:
2001:
1999:
1996:
1994:
1991:
1989:
1986:
1984:
1981:
1979:
1976:
1975:
1973:
1971:
1967:
1964:
1962:
1957:
1953:
1943:
1940:
1938:
1935:
1933:
1929:
1926:
1925:
1923:
1919:
1913:
1910:
1908:
1905:
1901:
1898:
1896:
1893:
1891:
1888:
1887:
1886:
1885:Neurofilament
1883:
1881:
1878:
1876:
1873:
1872:
1870:
1866:
1860:
1857:
1855:
1852:
1850:
1847:
1845:
1842:
1841:
1839:
1835:
1825:
1822:
1821:
1819:
1815:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1758:
1757:
1756:
1755:chromosome 12
1752:
1751:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1708:
1707:
1706:
1705:
1704:chromosome 17
1701:
1700:
1698:
1694:
1686:
1683:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1657:
1656:
1655:
1654:chromosome 12
1651:
1647:
1646:
1641:
1638:
1636:
1633:
1631:
1628:
1626:
1623:
1621:
1618:
1616:
1613:
1611:
1608:
1606:
1603:
1601:
1598:
1597:
1596:
1595:
1594:chromosome 17
1591:
1587:
1586:
1584:
1580:
1579:Hair keratins
1576:
1568:
1565:
1563:
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1533:
1530:
1528:
1525:
1523:
1520:
1519:
1518:
1517:
1516:chromosome 12
1513:
1509:
1508:
1503:
1500:
1499:
1498:
1495:
1491:
1488:
1487:
1486:
1485:
1484:chromosome 12
1481:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1428:
1427:
1426:
1425:chromosome 17
1422:
1418:
1417:
1415:
1411:
1407:
1404:
1401:
1396:
1389:
1386:
1384:
1381:Intermediate
1378:
1368:
1365:
1363:
1360:
1356:
1353:
1351:
1348:
1346:
1343:
1342:
1341:
1338:
1336:
1333:
1331:
1328:
1327:
1325:
1321:
1311:
1308:
1304:
1301:
1299:
1296:
1295:
1294:
1291:
1289:
1286:
1282:
1279:
1275:
1272:
1270:
1267:
1266:
1265:
1262:
1261:
1260:
1259:
1255:
1253:
1250:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1227:
1226:
1223:
1222:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1198:
1197:
1194:
1190:
1187:
1184:
1181:
1178:
1176:
1173:
1170:
1167:
1165:
1162:
1159:
1156:
1153:
1152:
1151:
1148:
1144:
1141:
1139:
1136:
1134:
1131:
1129:
1126:
1125:
1124:
1121:
1120:
1118:
1114:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1042:
1041:
1038:
1034:
1031:
1029:
1026:
1025:
1023:
1019:
1016:
1015:
1013:
1009:
1006:
1005:
1003:
999:
996:
994:
991:
990:
988:
984:
981:
979:
976:
975:
973:
969:
966:
965:
963:
959:
956:
954:
951:
949:
946:
945:
943:
939:
936:
934:
931:
930:
928:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
850:
848:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
804:
802:
801:
799:
797:
793:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
758:
756:
754:
750:
747:
745:
741:
738:
736:
731:
727:
724:
720:
716:
712:
705:
700:
698:
693:
691:
686:
685:
682:
676:
673:
670:
666:
663:
662:
658:
641:
637:
633:
629:
625:
624:
619:
612:
609:
604:
598:
590:
586:
581:
576:
572:
568:
564:
560:
556:
549:
547:
545:
541:
536:
532:
527:
522:
518:
514:
510:
506:
502:
498:
494:
487:
484:
479:
475:
471:
467:
463:
459:
454:
449:
445:
441:
437:
430:
427:
416:
412:
406:
403:
391:
387:
381:
378:
373:
369:
364:
359:
355:
351:
347:
343:
339:
335:
331:
324:
322:
318:
313:
309:
305:
301:
297:
293:
289:
285:
281:
274:
271:
258:
254:
250:
245:
240:
236:
232:
228:
224:
223:
218:
210:
208:
204:
197:
193:
190:
189:
185:
183:
180:
176:
167:
165:
163:
159:
155:
149:
147:
143:
139:
135:
131:
127:
116:
109:
107:
100:
98:
96:
92:
87:
85:
81:
77:
73:
69:
65:
61:
57:
53:
48:
45:
41:
37:
33:
29:
19:
3584:Tropoelastin
3540:
3513:
3481:
3391:
3381:
3364:
3354:
3325:
3280:
3230:
3184:
3162:
3113:
3106:
3094:
3075:
2994:
2769:Dystroglycan
2724:Beta catenin
1956:Microtubules
1824:Beta-keratin
1753:
1702:
1648:
1588:
1511:
1510:
1496:
1482:
1419:
1256:
1123:Tropomodulin
715:cytoskeleton
644:. Retrieved
627:
621:
611:
597:cite journal
562:
558:
500:
496:
486:
443:
439:
429:
418:. Retrieved
414:
405:
393:. Retrieved
390:www.bgee.org
389:
380:
337:
333:
287:
283:
273:
261:. Retrieved
226:
220:
179:heterodimers
171:
150:
122:
104:
88:
49:
43:
31:
27:
26:
3662:Cytokeratin
3591:Vitronectin
3272:multiplexin
2915:Plakophilin
2866:Desmoplakin
2626:Tau protein
1400:Cytokeratin
1196:Tropomyosin
744:Myofilament
3293:Endostatin
3282:type XVIII
2995:See also:
2967:Crescentin
2886:Periplakin
2876:Envoplakin
2764:Dystrophin
2381:axonemal:
1875:Internexin
1854:Peripherin
420:2023-05-03
198:References
156:(EHK) and
3672:Reticulin
3365:type VIII
2584:Centrin 3
2579:Centrin 2
2574:Centrin 1
1912:Syncoilin
1817:Not alpha
1383:filaments
1335:Fibrillin
517:0003-9861
462:0007-0963
411:"UniProt"
354:1432-119X
304:0171-9335
3708:Keratins
3702:Category
3687:diseases
3683:See also
3626:Tectorin
3445:Leprecan
3355:type VII
3185:type XII
3108:type III
3061:Collagen
2950:Nonhuman
2910:Vinculin
2871:Dystonin
2803:Spectrin
2776:Utrophin
2756:Membrane
2711:Catenins
2643:Stathmin
2631:Dynactin
2511:DYNC2LI1
2506:DYNC1LI2
2501:DYNC1LI1
2166:Kinesins
1970:Tubulins
1859:Vimentin
1391:Type 1/2
1293:Profilin
1288:Gelsolin
1150:Troponin
711:Proteins
640:Archived
589:29610398
535:21176769
478:21429676
470:10354017
372:18461349
312:16180309
257:Archived
253:16831889
186:See also
40:proteins
3667:Gelatin
3658:Keratin
3606:Decorin
3579:Elastin
3474:Laminin
3450:ADAMTS2
3424:Enzymes
3414:COL28A1
3409:COL27A1
3402:COL11A2
3397:COL11A1
3392:type XI
3386:COL10A1
3327:type VI
3324:other:
3318:COL25A1
3313:COL23A1
3308:COL17A1
3303:COL13A1
3288:COL18A1
3276:COL15A1
3232:type IV
3220:COL22A1
3215:COL21A1
3210:COL20A1
3205:COL19A1
3200:COL16A1
3195:COL14A1
3189:COL12A1
3163:type IX
3143:COL26A1
3138:COL24A1
3096:type II
3038:Protein
2937:PLEKHA7
2891:Plectin
2856:Plakins
2781:Ankyrin
2680:Dynamin
2610:Spastin
2605:Katanin
2569:CAMSAP3
2564:CAMSAP2
2559:CAMSAP1
2531:DYNLRB2
2526:DYNLRB1
2496:DYNC1I2
2491:DYNC1I1
2486:DYNC2H1
2481:DYNC1H1
2374:Dyneins
2098:TUBGCP6
2093:TUBGCP5
2088:TUBGCP4
2083:TUBGCP3
2078:TUBGCP2
1907:Synemin
1650:type II
1512:type II
1395:Keratin
1340:Filamin
1281:Destrin
1264:Cofilin
1225:Actinin
796:Myosins
713:of the
580:5880164
526:3142884
363:2386534
244:2064177
91:keratin
44:in vivo
3611:FAM20C
3382:type X
3375:COL8A2
3370:COL8A1
3359:COL7A1
3348:COL6A5
3343:COL6A3
3338:COL6A2
3333:COL6A1
3263:COL4A6
3258:COL4A5
3253:COL4A4
3248:COL4A3
3243:COL4A2
3238:COL4A1
3178:COL9A3
3173:COL9A2
3168:COL9A1
3131:COL5A3
3126:COL5A2
3121:COL5A1
3115:type V
3101:COL2A1
3088:COL1A2
3083:COL1A1
3077:type I
3052:matrix
2838:SPTBN5
2833:SPTBN4
2828:SPTBN2
2823:SPTBN1
2813:SPTAN1
2648:Tektin
2541:DYNLT3
2536:DYNLT1
2521:DYNLL2
2516:DYNLL1
2463:DNALI1
2448:DNAH17
2443:DNAH14
2438:DNAH13
2433:DNAH12
2428:DNAH11
2423:DNAH10
2344:KIF26B
2339:KIF26A
2314:KIF21B
2309:KIF21A
2304:KIF20B
2299:KIF20A
2289:KIF18B
2284:KIF18A
2274:KIF16B
2259:KIF13B
2254:KIF13A
2053:TUBB4Q
2038:TUBB2C
2033:TUBB2B
2028:TUBB2A
2008:TUBA4A
2003:TUBA3E
1998:TUBA3D
1993:TUBA3C
1988:TUBA1C
1983:TUBA1B
1978:TUBA1A
1921:Type 5
1880:Nestin
1868:Type 4
1844:Desmin
1837:Type 3
1590:type I
1421:type I
1367:TRIOBP
1033:MYO18B
1028:MYO18A
1024:XVIII
1018:MYO15A
753:Actins
671:(MeSH)
646:1 June
587:
577:
533:
523:
515:
476:
468:
460:
395:1 June
370:
360:
352:
310:
302:
263:1 June
251:
241:
144:, and
42:which
3651:Other
3636:TECTB
3631:TECTA
3601:FREM2
3596:FRAS1
3574:ALCAM
3567:Other
3556:LAMC3
3551:LAMC2
3546:LAMC1
3541:gamma
3534:LAMB4
3529:LAMB3
3524:LAMB2
3519:LAMB1
3507:LAMA5
3502:LAMA4
3497:LAMA3
3492:LAMA2
3487:LAMA1
3482:alpha
3159:FACIT
3152:Other
2898:Talin
2881:MACF1
2849:Other
2808:SPTA1
2673:TEKT5
2668:TEKT4
2663:TEKT3
2658:TEKT2
2653:TEKT1
2636:DCTN1
2619:Other
2473:DNAL4
2468:DNAL1
2458:DNAI2
2453:DNAI1
2418:DNAH9
2413:DNAH8
2408:DNAH7
2403:DNAH6
2398:DNAH5
2393:DNAH3
2388:DNAH2
2383:DNAH1
2364:KIFC3
2359:KIFC2
2354:KIFC1
2349:KIF27
2334:KIF25
2329:KIF24
2324:KIF23
2319:KIF22
2294:KIF19
2279:KIF17
2269:KIF15
2264:KIF14
2249:KIF12
2244:KIF11
2224:KIF5C
2219:KIF5B
2214:KIF5A
2209:KIF4B
2204:KIF4A
2199:KIF3C
2194:KIF3B
2189:KIF2C
2184:KIF2A
2179:KIF1B
2174:KIF1A
2146:MAP1B
2141:MAP1A
2108:TUBE1
2103:TUBD1
2073:TUBG2
2068:TUBG1
2063:TUBB8
2058:TUBB6
2048:TUBB4
2043:TUBB3
2023:TUBB1
2013:TUBA8
1362:Espin
1323:Other
1310:Titin
1116:Other
1105:MYLL1
1100:MYLK2
1090:MYLIP
1075:MYL6B
1008:MYO10
998:MYO9B
993:MYO9A
983:MYO7B
978:MYO7A
958:MYO5C
953:MYO5B
948:MYO5A
938:MYO3B
933:MYO3A
923:MYH16
918:MYH15
913:MYH14
908:MYH13
903:MYH11
898:MYH10
883:MYH7B
842:MYO1H
837:MYO1G
832:MYO1F
827:MYO1E
822:MYO1D
817:MYO1C
812:MYO1B
807:MYO1A
722:Human
474:S2CID
175:KRT6B
3616:ECM1
3514:beta
2982:ParM
2977:MreB
2972:FtsZ
2932:ACF7
2925:PKP2
2920:PKP1
2903:TLN1
2818:SPTB
2796:ANK3
2791:ANK2
2786:ANK1
2695:DNM3
2690:DNM2
2685:DNM1
2589:PCM1
2239:KIF9
2234:KIF7
2229:KIF6
2156:MAP4
2151:MAP2
2118:MAPs
2018:TUBB
1961:MAPs
1959:and
1900:NEFH
1895:NEFM
1890:NEFL
1849:GFAP
1497:none
1355:FLNC
1350:FLNB
1345:FLNA
1095:MYLK
1085:MYL9
1080:MYL7
1070:MYL6
1065:MYL5
1060:MYL4
1055:MYL3
1050:MYL2
1045:MYL1
974:VII
968:MYO6
929:III
893:MYH9
888:MYH8
878:MYH7
873:MYH6
868:MYH4
863:MYH3
858:MYH2
853:MYH1
735:ABPs
733:and
648:2023
603:link
585:PMID
531:PMID
513:ISSN
466:PMID
458:ISSN
397:2023
368:PMID
350:ISSN
308:PMID
300:ISSN
265:2023
249:PMID
82:and
30:(or
2746:GAN
2729:APC
2136:EB3
2131:EB2
2126:EB1
1932:A/C
1615:33B
1610:33A
1014:XV
989:IX
964:VI
849:II
632:doi
628:107
575:PMC
567:doi
521:PMC
505:doi
501:508
448:doi
444:140
358:PMC
342:doi
338:129
292:doi
239:PMC
231:doi
227:174
146:K78
142:K77
138:K10
84:CK8
80:CK7
76:CK6
72:CK5
68:CK4
64:CK3
60:CK2
56:CK1
3704::
3274::
3229::
3161::
3040::
1942:B2
1937:B1
1930::
1806:80
1801:79
1796:78
1791:77
1786:76
1781:75
1776:74
1771:73
1766:72
1761:71
1745:40
1740:39
1735:28
1730:27
1725:26
1720:25
1715:24
1710:23
1685:86
1680:85
1675:84
1670:83
1665:82
1660:81
1640:38
1635:37
1630:36
1625:35
1620:34
1605:32
1600:31
1557:6C
1552:6B
1547:6A
1527:2A
1502:21
1490:18
1476:20
1471:19
1466:17
1461:16
1456:15
1451:14
1446:13
1441:12
1436:10
1040:LC
1004:X
944:V
803:I
786:G2
781:G1
776:C1
766:A2
761:A1
638:.
626:.
620:.
599:}}
595:{{
583:.
573:.
563:10
561:.
557:.
543:^
529:.
519:.
511:.
499:.
495:.
472:.
464:.
456:.
442:.
438:.
413:.
388:.
366:.
356:.
348:.
336:.
332:.
320:^
306:.
298:.
288:84
286:.
282:.
255:.
247:.
237:.
225:.
219:.
206:^
140:,
136:,
134:K9
132:,
130:K2
128:,
126:K1
78:,
74:,
70:,
66:,
62:,
58:,
3660:/
3443:/
3434:/
3388:)
3384:(
3361:)
3357:(
3191:)
3187:(
3103:)
3099:(
3030:e
3023:t
3016:v
1652:/
1592:/
1567:8
1562:7
1542:5
1537:4
1532:3
1522:1
1514:/
1431:9
1423:/
1402:)
1397:,
1393:(
1303:2
1298:1
1274:2
1269:1
1245:4
1240:3
1235:2
1230:1
1216:4
1211:3
1206:2
1201:1
1189:3
1186:2
1183:1
1180:I
1175:2
1172:1
1169:C
1164:3
1161:2
1158:1
1155:T
1143:4
1138:3
1133:2
1128:1
844:)
771:B
703:e
696:t
689:v
650:.
634::
605:)
591:.
569::
537:.
507::
480:.
450::
423:.
399:.
374:.
344::
314:.
294::
267:.
233::
20:)
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