1982:
1966:
2233:. This is a progressive and often lethal disorder, which can be improved but not cured by levodopa. Due to the low number of patients and overlapping symptoms with other disorders, early diagnosis and treatment remain challenging. Response to treatment is variable and the long-term and functional outcome is unknown. To provide a basis for improving the understanding of the epidemiology, genotype/phenotype correlation and outcome of these diseases, their impact on the quality of life of patients, and for evaluating diagnostic and therapeutic strategies, a patient registry was established by the noncommercial
29:
306:
283:
180:
205:
1589:
2084:
5098:
5083:
557:
312:
211:
7822:
2135:
Tyrosine hydroxylase is mainly present in the cytosol, although it also is found in some extent in the plasma membrane. The membrane association may be related to catecholamine packing in vesicles and export through the synaptic membrane. The binding of tyrosine hydroxylase to membranes involves the
2127:
to a lesser extent than for Ser40 phosphorylation. The phosphorylation at Ser19 and Ser8 has no direct effect on tyrosine hydroxylase activity. But phosphorylation at Ser19 increases the rate of phosphorylation at Ser40, leading to an increase in enzyme activity. Phosphorylation at Ser19 causes a
2260:, it makes an indirect link between tyrosine hydroxylase and these diseases. The activity of tyrosine hydroxylase in the brains of patients with Alzheimer's disease has been shown to be significantly reduced compared to healthy individuals. Tyrosine hydroxylase is also an autoantigen in
55:
4075:
Thibaut F, Ribeyre JM, Dourmap N, Meloni R, Laurent C, Campion D, Ménard JF, Dollfus S, Mallet J, Petit M (Feb 1997). "Association of DNA polymorphism in the first intron of the tyrosine hydroxylase gene with disturbances of the catecholaminergic system in schizophrenia".
2139:
Tyrosine hydroxylase can also be regulated by inhibition. Phosphorylation at Ser40 relieves feedback inhibition by the catecholamines dopamine, epinephrine, and norepinephrine. The catecholamines trap the active-site iron in the Fe(III) state, inhibiting the enzyme.
4703:
Le
Bourdellès B, Boularand S, Boni C, Horellou P, Dumas S, Grima B, Mallet J (Mar 1988). "Analysis of the 5' region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms".
2331:. Like other cellular proteins, tyrosine hydroxylase is also a possible target for damaging alterations induced by ROS. This suggests that some of the oxidative damage to tyrosine hydroxylase could be generated by the tyrosine hydroxylase system itself.
4600:
Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T (Aug 1987). "Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene".
4776:
Kobayashi K, Kaneda N, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T (Jun 1988). "Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types".
3008:
Kobayashi K, Kaneda N, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T (Jun 1988). "Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types".
4198:
Hedstrand H, Ekwall O, Haavik J, Landgren E, Betterle C, Perheentupa J, Gustafsson J, Husebye E, Rorsman F, Kämpe O (Jan 2000). "Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I".
2023:
domain that allows tetramerization. The central ~300 amino acids make up a catalytic core, in which all the residues necessary for catalysis are located, along with a non-covalently bound iron atom. The iron is held in place by two
4673:
O'Malley KL, Anhalt MJ, Martin BM, Kelsoe JR, Winfield SL, Ginns EI (Nov 1987). "Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs".
4154:
Sawada M, Hirata Y, Arai H, Iizuka R, Nagatsu T (Mar 1987). "Tyrosine hydroxylase, tryptophan hydroxylase, biopterin, and neopterin in the brains of normal controls and patients with senile dementia of
Alzheimer type".
3920:
Bobrovskaya L, Gilligan C, Bolster EK, Flaherty JJ, Dickson PW, Dunkley PR (Jan 2007). "Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis".
3090:
Obsilova V, Nedbalkova E, Silhan J, Boura E, Herman P, Vecer J, Sulc M, Teisinger J, Dyda F, Obsil T (Feb 2008). "The 14-3-3 protein affects the conformation of the regulatory domain of human tyrosine hydroxylase".
2132:. Phosphorylation at Ser31 causes a slight increase of activity, and here the mechanism is unknown. Tyrosine hydroxylase is somewhat stabilized to heat inactivation when the regulatory serines are phosphorylated.
4347:
Meloni R, Biguet NF, Mallet J (2002). "Post-genomic era and gene discovery for psychiatric diseases: there is a new art of the trade? The example of the HUMTH01 microsatellite in the
Tyrosine Hydroxylase gene".
3172:
Goodwill KE, Sabatier C, Stevens RC (Sep 1998). "Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site".
2234:
1981:
5255:
3129:
Goodwill KE, Sabatier C, Marks C, Raag R, Fitzpatrick PF, Stevens RC (Jul 1997). "Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases".
5026:
GeneReviews/NIH/NCBI/UW entry on
Tyrosine Hydroxylase Deficiency including Tyrosine Hydroxylase-Deficient Dopa-Responsive Dystonia or Segawa Syndrome and Autosomal Recessive Infantile Parkinsonism
2796:
Fitzpatrick PF (1994). "Kinetic
Isotope Effects on Hydroxylation of Ring-Deuterated Phenylalanines by Tyrosine Hydroxylase Provide Evidence against Partitioning of an Arene Oxide Intermediate".
4989:
Knappskog PM, Flatmark T, Mallet J, Lüdecke B, Bartholomé K (Jul 1995). "Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene".
2252:. Tyrosine hydroxylase is activated by phosphorylation dependent binding to 14-3-3 proteins. Since the 14-3-3 proteins also are likely to be associated with neurodegenerative diseases such as
4806:
Coker GT, Vinnedge L, O'Malley KL (Dec 1988). "Characterization of rat and human tyrosine hydroxylase genes: functional expression of both promoters in neuronal and non-neuronal cell types".
2119:(mitogen-activated-protein kinase-activating protein kinase) has a preference for Ser40, but also phosphorylates Ser19 about half the rate of Ser40. Ser31 is phosphorylated by ERK1 and ERK2 (
2056:, which doesn't weaken suspicions of it having a disordered overall structure. As for the tetramerization and catalytic domains their structure was found with rat tyrosine hydroxylase using
6400:
4555:
Grima B, Lamouroux A, Boni C, Julien JF, Javoy-Agid F, Mallet J (1987). "A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics".
2136:
N-terminal region of the enzyme, and may be regulated by a three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes.
1933:
derivatives - which is unusual as many other enzymes involved in the production of catecholamines do. Tryptophan is a poor substrate for tyrosine hydroxylase, however it can hydroxylate
1973:, the tetramerization domain (pink) and the catalytic domain (blue). The regulatory domain (not shown) would sit somewhere on the right hand side of the image where also the enzyme's
4526:
Craig SP, Buckle VJ, Lamouroux A, Mallet J, Craig I (1986). "Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways".
2290:, tyrosine hydroxylase-deficiency does not cause Parkinson's disease, but typically gives rise to infantile parkinsonism, although the spectrum extends to a condition resembling
3833:
Ramsey AJ, Fitzpatrick PF (Jun 1998). "Effects of phosphorylation of serine 40 of tyrosine hydroxylase on binding of catecholamines: evidence for a novel regulatory mechanism".
2072:
1568:
609:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
5248:
4870:
Zhou QY, Quaife CJ, Palmiter RD (Apr 1995). "Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development".
3047:
Nakashima A, Hayashi N, Kaneko YS, Mori K, Sabban EL, Nagatsu T, Ota A (Nov 2009). "Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines".
1772:
319:
218:
5138:
3640:
Royo M, Fitzpatrick PF, Daubner SC (Feb 2005). "Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity".
6393:
3208:
Ledley FD, DiLella AG, Kwok SC, Woo SL (Jul 1985). "Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains".
1791:
5241:
5097:
5082:
1844:-DOPA and the other one is used to hydroxylate the cofactor. Like the other aromatic amino acid hydroxylases (AAAHs), tyrosine hydroxylase use the cofactor
2349:-3,4-dyhydroxyphenylalanine) which is synthesized by tyrosine hydroxylase. This drug is rarely used and can cause depression, but it is useful in treating
3483:"Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2"
2591:
Teigen K, McKinney JA, Haavik J, Martínez A (2007). "Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases".
1185:
2112:
1166:
52:
141:
6386:
5867:
2265:
1895:
of this iron atom is important for the catalytic turnover in the enzymatic reaction. If the iron is oxidized to Fe(III), the enzyme is inactivated.
5760:
3583:"Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases"
3343:
Roskoski R, Roskoski LM (Jan 1987). "Activation of tyrosine hydroxylase in PC12 cells by the cyclic GMP and cyclic AMP second messenger systems".
2825:"Isolation and characterization of tetrahydropterin oxidation products generated in the tyrosine 3-monooxygenase (tyrosine hydroxylase) reaction"
7791:
7229:
5935:
5674:
5393:
3794:"Site-directed mutagenesis of serine 40 of rat tyrosine hydroxylase. Effects of dopamine and cAMP-dependent phosphorylation on enzyme activity"
2120:
1875:) by the enzyme pterin-4a-carbinolamine dehydrase (PCD) and a water molecule is released in this reaction. Then, the NAD(P)H dependent enzyme
7842:
5062:
2476:
2441:
2423:
2040:. In humans there are thought to be four different versions of this regulatory domain, and thus four versions of the enzyme, depending on
4952:
Lüdecke B, Dworniczak B, Bartholomé K (Jan 1995). "A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome".
7795:
7540:
6430:
5835:
5570:
5536:
5522:
5379:
5131:
4234:
Ono M, Okamoto M, Kawabe N, Umezawa H, Takeuchi T (Mar 1971). "Oudenone, a novel tyrosine hydroxylase inhibitor from microbial origin".
1914:-DOPA is the precursor for the neurotransmitters dopamine, noradrenaline and adrenaline, tyrosine hydroxylase is therefore found in the
1903:
4440:"ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ"
3524:"ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ"
2867:, Walker SJ, Rucker P, Liu X (Dec 1994). "A carboxyl terminal leucine zipper is required for tyrosine hydroxylase tetramer formation".
305:
2045:
1420:
3868:
Dewing P, Chiang CW, Sinchak K, Sim H, Fernagut PO, Kelly S, Chesselet MF, Micevych PE, Albrecht KH, Harley VR, Vilain E (Feb 2006).
2052:, but so far no evidence has been presented supporting this claim. It has however been shown that the domain has a low occurrence of
6109:
5808:
2261:
1965:
1413:
282:
1784:
5531:
3743:"Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes"
6617:
6595:
5847:
5793:
2410:
2389:
2194:
1735:
7799:
7510:
7331:
6630:
5124:
4387:"Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation"
2171:
1876:
1711:
204:
179:
6265:
2406:
7651:
7279:
5652:
5413:
5328:
3245:"Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases"
7812:
2385:
2338:). This inhibition can lead to a depletion of dopamine and norepinepherine in the brain due to the lack of the precursor
7771:
5487:
2291:
2044:, though none of their structures have yet been properly determined. It has been suggested that this domain might be an
121:
28:
7621:
7159:
6076:
5925:
3679:
7340:
7335:
7020:
6648:
6608:
6586:
6409:
5667:
5276:
4011:"Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia—A Focus on Tyrosine Hydroxylase Deficiency"
6250:
1852:) under normal conditions, although other similar molecules may also work as a cofactor for tyrosine hydroxylase.
318:
217:
7046:
6524:
6366:
6353:
6340:
6327:
6314:
6301:
6288:
6071:
6032:
6022:
6008:
6004:
5994:
5982:
5962:
5945:
5913:
5877:
5777:
5704:
5608:
5388:
5055:
2061:
1907:
1729:
1560:
6260:
2505:
Nagatsu T (1995). "Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology".
6214:
6157:
5695:
5034:
2175:
1990:
1974:
1622:
1230:
311:
210:
129:
5917:
5212:
1716:
1910:, which can be further modified by the enzyme phenylethanol N-methyltransferase to obtain epinephrine. Since
7583:
6162:
5708:
5467:
5448:
5308:
2310:
2257:
1521:
1211:
7741:
5116:
4009:
Nygaard G, Szigetvar PD, Grindheim AK, Ruoff P, Martinez A, Jaavik J, Kleppe R, Flydal MI (November 2021).
7787:
7783:
7779:
7626:
7460:
7439:
6563:
6056:
5972:
5721:
5517:
5025:
3680:"Demonstration of functional coupling between dopamine synthesis and its packaging into synaptic vesicles"
2272:
2253:
2245:
2240:
Furthermore, alterations in the tyrosine hydroxylase enzyme activity may be involved in disorders such as
2065:
1989:(Slc6a4) in green and nuclear DNA in blue in a region of rat brain stem. Antibody staining and imaging by
1796:
1564:
1552:
2279:, leading to a reduction of striatal dopamine levels. As tyrosine hydroxylase catalyzes the formation of
1704:
7344:
6621:
6599:
6183:
6102:
5852:
5825:
5660:
5636:
5562:
5155:
4915:
Lüdecke B, Bartholomé K (Jun 1995). "Frequent sequence variant in the human tyrosine hydroxylase gene".
2912:"Identification of iron ligands in tyrosine hydroxylase by mutagenesis of conserved histidinyl residues"
2057:
1986:
193:
7671:
6255:
3741:
Halskau Ø, Ying M, Baumann A, Kleppe R, Rodriguez-Larrea D, Almås B, Haavik J, Martinez A (Nov 2009).
7775:
7076:
5930:
5691:
5632:
5048:
4879:
4741:
Ginns EI, Rehavi M, Martin BM, Weller M, O'Malley KL, LaMarca ME, McAllister CG, Paul SM (May 1988).
4564:
4451:
4398:
3594:
3535:
3388:"Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation"
3256:
2241:
2041:
1868:
1639:
108:
4630:
Kobayashi K, Kaneda N, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T (Aug 1987).
1732:
7847:
7214:
6938:
6219:
5953:
5428:
5423:
3964:
Pearl PL, Taylor JL, Trzcinski S, Sokohl A (May 2007). "The pediatric neurotransmitter disorders".
2463:. Advances in Enzymology - and Related Areas of Molecular Biology. Vol. 70. pp. 103–220.
2143:
It has been shown that the expression of tyrosine hydroxylase can be affected by the expression of
2053:
1845:
1656:
1634:
1517:
7405:
7002:
6997:
1588:
1375:
1371:
7390:
7371:
7367:
7353:
7349:
7119:
6920:
6572:
6152:
5716:
5207:
4977:
4940:
4903:
4729:
4588:
4373:
4335:
4180:
4101:
3991:
3946:
3899:
3720:
3463:
3368:
3154:
3072:
2892:
2570:
2154:
Long term regulation of tyrosine hydroxylase can also be mediated by phosphorylation mechanisms.
2049:
1923:
153:
7259:
5862:
5030:
4743:"Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector"
4314:
Masserano JM, Weiner N (1983). "Tyrosine hydroxylase regulation in the central nervous system".
2103:(Ser) residues, including Ser8, Ser19, Ser31 and Ser40, that are phosphorylated by a variety of
1836:
which means it uses molecular oxygen to hydroxylate its substrates. One of the oxygen atoms in O
1396:
1367:
1363:
1359:
1333:
1312:
1308:
1304:
16:
Enzyme found in Homo sapiens that converts l-tyrosine to l-dopa, the precursor of cathecolamines
7696:
7264:
3481:
Sutherland C, Alterio J, Campbell DG, Le
Bourdellès B, Mallet J, Haavik J, Cohen P (Oct 1993).
1949:-DOPA. Tyrosine hydroxylase may also be involved in other reactions as well, such as oxidizing
7556:
7530:
7500:
7308:
7299:
7269:
6860:
6639:
6635:
6544:
5750:
5418:
5006:
4969:
4932:
4895:
4858:
4823:
4794:
4764:
4721:
4691:
4661:
4618:
4580:
4543:
4514:
4479:
4426:
4365:
4327:
4292:
4251:
4216:
4172:
4136:
4093:
4043:
3983:
3938:
3891:
3850:
3815:
3774:
3712:
3657:
3622:
3563:
3504:
3455:
3409:
3360:
3325:
3284:
3225:
3190:
3146:
3108:
3064:
3026:
2990:
2941:
2884:
2846:
2778:
2738:
2694:
2653:
2608:
2562:
2514:
2482:
2472:
2299:
2183:
2167:
2083:
2069:
2016:
1821:
1723:
101:
45:
2036:~150 amino acids make up a regulatory domain, thought to control access of substrates to the
7395:
7380:
7376:
7362:
7358:
7124:
6840:
6756:
6415:
6198:
6193:
6167:
6095:
5268:
5174:
4998:
4961:
4924:
4887:
4848:
4815:
4786:
4754:
4713:
4683:
4651:
4643:
4610:
4572:
4535:
4504:
4469:
4459:
4416:
4406:
4357:
4319:
4282:
4243:
4208:
4164:
4128:
4085:
4033:
4023:
3975:
3930:
3881:
3842:
3805:
3764:
3754:
3702:
3694:
3649:
3612:
3602:
3553:
3543:
3494:
3445:
3399:
3352:
3315:
3274:
3264:
3217:
3182:
3138:
3100:
3056:
3018:
2980:
2972:
2931:
2923:
2876:
2836:
2805:
2770:
2728:
2684:
2673:"Characterization of the active site iron in tyrosine hydroxylase. Redox states of the iron"
2643:
2635:
2600:
2554:
2464:
2350:
2276:
2148:
2108:
1941:-tyrosine and small amounts of 3-hydroxyphenylalanine. The enzyme can then further catalyze
1692:
1505:
398:
329:
273:
228:
7721:
7686:
7317:
6776:
6613:
6245:
6229:
6142:
5840:
5574:
5333:
5147:
4790:
3022:
2222:
2159:
2129:
2124:
2104:
2096:
2004:
1892:
1668:
1556:
556:
373:
1627:
1540:(adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of
5233:
4883:
4568:
4455:
4402:
3598:
3581:
Ichimura T, Isobe T, Okuyama T, Takahashi N, Araki K, Kuwano R, Takahashi Y (Oct 1988).
3539:
3260:
2880:
2320:
is effectively oxidized by mammalian tyrosine hydroxylase, possibly contributing to the
149:
7826:
7313:
7245:
7179:
7129:
7035:
6866:
6604:
6483:
6283:
6224:
6066:
6046:
6041:
5683:
5628:
5151:
4717:
4168:
4038:
4010:
3966:
3769:
3742:
3499:
3482:
3356:
2985:
2960:
2936:
2911:
2841:
2824:
2648:
2627:
2210:
2206:
2178:. Increase in tyrosine hydroxylase activity due to phosphorylation can be sustained by
2033:
2012:
1970:
1919:
1767:
1541:
1533:
4853:
4836:
4819:
4759:
4742:
4656:
4631:
4509:
4492:
4421:
4386:
4089:
3810:
3793:
3617:
3582:
3320:
3303:
3279:
3244:
2733:
2716:
1747:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
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1020:
1015:
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1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
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775:
759:
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749:
744:
739:
734:
729:
724:
719:
714:
709:
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689:
684:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
598:
7836:
7616:
7062:
6726:
6706:
6671:
6479:
6188:
6147:
5589:
5444:
4837:"Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase"
4614:
4474:
4439:
4015:
3934:
3558:
3523:
3450:
3433:
2774:
2249:
2182:
for up to 48 hours. Tyrosine hydroxylase activity is regulated chronically (days) by
2088:
1817:
1742:
585:
4981:
4733:
4339:
4184:
4105:
3995:
3950:
3467:
3432:
Dunkley PR, Bobrovskaya L, Graham ME, von Nagy-Felsobuki EI, Dickson PW (Dec 2004).
3372:
3158:
2896:
2574:
7641:
7420:
7326:
7204:
7139:
6891:
6871:
6766:
6761:
6751:
6676:
6591:
6137:
5885:
5881:
5554:
5217:
4944:
4907:
4592:
4377:
4119:
Steinacker P, Aitken A, Otto M (Sep 2011). "14-3-3 proteins in neurodegeneration".
3903:
3724:
2354:
2298:
role of tyrosine hydroxylase has also been suggested, as the enzyme is a source of
2295:
2008:
1922:. This initial reaction catalyzed by tyrosine hydroxylase has been shown to be the
391:
170:
6378:
4632:"Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3"
3076:
133:
4132:
157:
7681:
7599:
7322:
7249:
7134:
7030:
6881:
6810:
6805:
6800:
6696:
6686:
6582:
6514:
6467:
6361:
6296:
6132:
5355:
5202:
5186:
5181:
4361:
2639:
2446:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2428:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2362:
2230:
2202:
2037:
2020:
1751:
1537:
7821:
4444:
Proceedings of the
National Academy of Sciences of the United States of America
4391:
Proceedings of the
National Academy of Sciences of the United States of America
4287:
4270:
3587:
Proceedings of the National Academy of Sciences of the United States of America
3528:
Proceedings of the National Academy of Sciences of the United States of America
3249:
Proceedings of the National Academy of Sciences of the United States of America
2604:
2313:(ROS), and a target for radical-mediated injury. It has been demonstrated that
474:
7751:
7701:
7636:
7631:
7495:
7476:
7410:
7400:
7209:
7194:
7189:
7144:
6988:
6983:
6978:
6963:
6958:
6953:
6948:
6930:
6925:
6901:
6896:
6886:
6830:
6820:
6815:
6795:
6746:
6741:
6721:
6701:
6691:
6681:
6666:
6534:
6504:
6500:
6488:
6412:
6017:
5501:
3886:
3869:
3653:
3060:
2976:
2864:
2545:
Haavik J, Toska K (Jun 1998). "Tyrosine hydroxylase and Parkinson's disease".
2468:
2335:
1487:
1484:
290:
187:
137:
4647:
4493:"Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40"
3979:
3304:"Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40"
2761:
Fitzpatrick PF (1999). "Tetrahydropterin-dependent amino acid hydroxylases".
2689:
2672:
7737:
7706:
7691:
7667:
7606:
7574:
7560:
7526:
7449:
7445:
7425:
7415:
7219:
6973:
6876:
6856:
6848:
6771:
6736:
6731:
6716:
6711:
6644:
6529:
6519:
6474:
6462:
6335:
6309:
5986:
5949:
5893:
5687:
5509:
5505:
5289:
5285:
4411:
3759:
3607:
3269:
2321:
2029:
2025:
1833:
1809:
1545:
1130:
534:
412:
357:
344:
256:
243:
145:
5002:
4464:
4369:
4220:
4212:
4140:
4047:
3987:
3942:
3895:
3870:"Direct regulation of adult brain function by the male-specific factor SRY"
3778:
3716:
3661:
3548:
3459:
3413:
3404:
3387:
3112:
3068:
2994:
2927:
2782:
2742:
2657:
2612:
2032:
residue, making it a non-heme, non-iron-sulfur iron-containing enzyme. The
1887:. Each of the four subunits in tyrosine hydroxylase is coordinated with an
5010:
4973:
4936:
4899:
4862:
4827:
4798:
4768:
4725:
4695:
4665:
4622:
4584:
4547:
4518:
4483:
4331:
4296:
4255:
4176:
4097:
3854:
3819:
3626:
3567:
3508:
3364:
3329:
3288:
3229:
3194:
3150:
3030:
2945:
2888:
2850:
2698:
2566:
2518:
2486:
2334:
Tyrosine hydroxylase can be inhibited by the drug α-methyl-para-tyrosine (
1460:
1455:
7490:
7295:
7199:
7175:
7149:
7102:
7066:
7026:
6968:
6835:
6661:
6626:
6495:
6453:
5765:
5550:
5351:
5347:
5169:
3386:
Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR, Dickson PW (Jun 2006).
2358:
2287:
2218:
2214:
2198:
2179:
2155:
2116:
2000:
1680:
1594:
1529:
1444:
1279:
1260:
1256:
4687:
4430:
4247:
4028:
3221:
3142:
2809:
7711:
6943:
6852:
6844:
6061:
5585:
4965:
4928:
4323:
2717:"Tyrosine Hydroxylase. The Initial Step in Norepinephrine Biosynthesis"
2558:
2163:
1915:
1699:
1513:
1242:
1197:
4539:
3846:
3707:
3698:
3186:
3104:
78:
74:
7106:
6446:
6348:
6118:
5903:
5898:
5857:
5264:
5106:: TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT
5091:: TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT
4891:
4576:
2226:
2128:
two-fold increase of activity, through a mechanism that requires the
2100:
1930:
1779:
1675:
1663:
1651:
1598:
1532:, which, in turn, is a precursor for the important neurotransmitters
1494:
1480:
1428:
1152:
3434:"Tyrosine hydroxylase phosphorylation: regulation and consequences"
2357:. Older examples of inhibitors mentioned in the literature include
112:, Th, DYT14, DYT5b, TYH, tyrosine hydroxylase, Tyrosine hydroxylase
7480:
7304:
6825:
6458:
6322:
6050:
5785:
5743:
5736:
5731:
5726:
2099:. The regulatory domain of tyrosine hydroxylase contains multiple
2082:
1980:
1964:
2235:
International Working Group on Neurotransmitter Related Disorders
2111:. Ser19 (and Ser40 to a lesser extent) is phosphorylated by the
1115:
1111:
5830:
5818:
5813:
5803:
5798:
5781:
5755:
5566:
2095:
Tyrosine hydroxylase activity is increased in the short term by
1888:
1687:
125:
6382:
6091:
5656:
5237:
5120:
5044:
4269:
Ayukawa S, Takeuchi T, Sezaki M, Hara T, Umezawa H (May 1968).
3792:
Daubner SC, Lauriano C, Haycock JW, Fitzpatrick PF (Jun 1992).
1855:
The AAAHs converts the cofactor 5,6,7,8-tetrahydrobiopterin (BH
565:
7230:
5040:
2910:
Ramsey AJ, Daubner SC, Ehrlich JI, Fitzpatrick PF (Oct 1995).
2628:"Tetrahydrobiopterin biosynthesis, regeneration and functions"
2144:
2060:. This has shown how its structure is very similar to that of
1906:. Dopamine may be converted into norepinephrine by the enzyme
2461:
Advances in Enzymology and Related Areas of Molecular Biology
2151:
can result in a decrease in tyrosine hydroxylase expression.
7541:
6431:
2961:"Tyrosine hydroxylase and regulation of dopamine synthesis"
6087:
4061:
2087:
Tyrosine hydroxylase catalyzes the rate limiting step in
1101:
aminergic neurotransmitter loading into synaptic vesicle
381:
1840:
is used to hydroxylate the tyrosine molecule to obtain
7511:
7810:
7652:
7280:
546:
1902:-DOPA, can be transformed to dopamine by the enzyme
1544:. In humans, tyrosine hydroxylase is encoded by the
7720:
7650:
7582:
7573:
7539:
7509:
7459:
7438:
7278:
7228:
7160:
7158:
7085:
7045:
7019:
6543:
6429:
6422:
6274:
6238:
6207:
6176:
6125:
6031:
6003:
5981:
5944:
5912:
5876:
5776:
5703:
5617:
5597:
5584:
5549:
5500:
5476:
5456:
5443:
5402:
5363:
5346:
5317:
5297:
5284:
5275:
5195:
5162:
4808:
Biochemical and Biophysical Research Communications
4603:
Biochemical and Biophysical Research Communications
4271:"Inhibition of tyrosine hydroxylase by aquayamycin"
4201:
Biochemical and Biophysical Research Communications
3243:Grenett HE, Ledley FD, Reed LL, Woo SL (Aug 1987).
1790:
1778:
1766:
1761:
1741:
1722:
1710:
1698:
1686:
1674:
1662:
1650:
1645:
1633:
1621:
1616:
1581:
1389:
1352:
1326:
1297:
4438:Haycock JW, Ahn NG, Cobb MH, Krebs EG (Mar 1992).
3522:Haycock JW, Ahn NG, Cobb MH, Krebs EG (Mar 1992).
2402:
2400:
2398:
2381:
2379:
2377:
1859:) into tetrahydrobiopterin-4a-carbinolamine (4a-BH
7047:
2671:Ramsey AJ, Hillas PJ, Fitzpatrick PF (Oct 1996).
1969:Tyrosine hydroxylase from rat showing two of its
1483:responsible for catalyzing the conversion of the
328:
227:
2286:, the rate-limiting step in the biosynthesis of
7584:
3915:
3913:
3736:
3734:
3673:
3671:
3427:
3425:
3423:
3042:
3040:
2756:
2754:
2752:
2710:
2708:
2275:is degeneration of dopaminergic neurons in the
7461:
7235:Tooltip Phenylethanolamine N-methyltransferase
6564:
3124:
3122:
2715:Nagatsu T, Levitt M, Udenfriend S (Sep 1964).
2586:
2584:
2407:GRCm38: Ensembl release 89: ENSMUSG00000000214
2213:and poor prognosis. Clinical features include
1555:(CNS), peripheral sympathetic neurons and the
6394:
6103:
5668:
5249:
5132:
5056:
4835:Vulliet PR, Woodgett JR, Cohen P (Nov 1984).
2540:
2538:
2536:
2534:
2532:
2530:
2528:
2500:
2498:
2496:
2147:. The down regulation of the SRY gene in the
1929:The enzyme is highly specific, not accepting
1593:Tyrosine hydroxylase catalyzes conversion of
8:
7087:
4121:Seminars in Cell & Developmental Biology
1891:(II) atom presented in the active site. The
981:aromatic amino acid family metabolic process
7546:Tooltip Acetylserotonin O-methyltransferase
6436:Tooltip Aromatic L-amino acid decarboxylase
2386:GRCh38: Ensembl release 89: ENSG00000180176
2113:calcium-calmodulin-dependent protein kinase
1096:dopamine biosynthetic process from tyrosine
1041:cellular response to growth factor stimulus
7579:
7456:
7042:
6573:
6554:
6426:
6401:
6387:
6379:
6110:
6096:
6088:
5675:
5661:
5653:
5594:
5453:
5360:
5294:
5281:
5256:
5242:
5234:
5139:
5125:
5117:
5063:
5049:
5041:
2459:Kaufman S (1995). "Tyrosine hydroxylase".
1953:-DOPA to form 5-S-cysteinyl-DOPA or other
1758:
1587:
1126:
581:
369:
268:
165:
63:
6545:
5033:at the U.S. National Library of Medicine
4852:
4758:
4655:
4508:
4473:
4463:
4420:
4410:
4286:
4037:
4027:
3885:
3809:
3768:
3758:
3706:
3616:
3606:
3557:
3547:
3498:
3449:
3403:
3319:
3278:
3268:
2984:
2935:
2840:
2732:
2688:
2647:
2068:; together the three make up a family of
4236:Journal of the American Chemical Society
3678:Chen R, Wei J, Fowler SC, Wu JY (2003).
2798:Journal of the American Chemical Society
2626:Thöny B, Auerbach G, Blau N (Apr 2000).
1863:). Under physiological conditions, 4a-BH
7817:
7722:
5078:
3642:Archives of Biochemistry and Biophysics
2965:Archives of Biochemistry and Biophysics
2373:
1898:The product of the enzymatic reaction,
901:embryonic camera-type eye morphogenesis
796:isoquinoline alkaloid metabolic process
7516:Tooltip Serotonin N-acetyl transferase
5394:Phenylethanolamine N-methyltransferase
2217:that is minimally or nonresponsive to
1578:
18:
7657:Tooltip Histamine N-methyltransferase
7285:Tooltip Catechol-O-methyl transferase
4791:10.1093/oxfordjournals.jbchem.a122386
4385:Joh TH, Park DH, Reis DJ (Oct 1978).
3023:10.1093/oxfordjournals.jbchem.a122386
2959:Daubner SC, Le T, Wang S (Apr 2011).
2209:. It is represented by a progressive
2019:of the peptide chain there's a short
1926:in the production of catecholamines.
1061:neurotransmitter biosynthetic process
851:cellular response to glucose stimulus
333:
294:
289:
232:
191:
186:
7:
5868:24-hydroxycholesterol 7α-hydroxylase
7165:Tooltip Dopamine beta-monooxygenase
5537:Acetylserotonin O-methyltransferase
4841:The Journal of Biological Chemistry
4747:The Journal of Biological Chemistry
4497:The Journal of Biological Chemistry
4316:Molecular and Cellular Biochemistry
3798:The Journal of Biological Chemistry
3747:The Journal of Biological Chemistry
3392:The Journal of Biological Chemistry
3308:The Journal of Biological Chemistry
2881:10.1046/j.1471-4159.1994.63062014.x
2721:The Journal of Biological Chemistry
2677:The Journal of Biological Chemistry
1871:to quinonoid-dihydrobiopterin (q-BH
1551:, and the enzyme is present in the
1031:response to organic cyclic compound
931:norepinephrine biosynthetic process
821:synaptic transmission, dopaminergic
705:cytoplasmic side of plasma membrane
4718:10.1111/j.1471-4159.1988.tb03009.x
4169:10.1111/j.1471-4159.1987.tb05582.x
3500:10.1111/j.1432-1033.1993.tb18297.x
3357:10.1111/j.1471-4159.1987.tb13153.x
2842:10.1111/j.1432-1033.1987.tb13381.x
2046:intrinsically unstructured protein
2011:). Each subunit consists of three
1386:
1349:
1323:
1294:
1270:
1247:
1221:
1202:
1176:
1157:
1086:eye photoreceptor cell development
1056:catecholamine biosynthetic process
911:cellular response to manganese ion
871:anatomical structure morphogenesis
551:
469:
407:
386:
14:
7052:Tooltip Phenylalanine hydroxylase
2823:Haavik J, Flatmark T (Oct 1987).
2262:autoimmune polyendocrine syndrome
2107:. Ser40 is phosphorylated by the
926:response to immobilization stress
604:tyrosine 3-monooxygenase activity
7820:
5532:Aralkylamine N-acetyltransferase
5096:
5081:
3935:10.1111/j.1471-4159.2006.04213.x
3487:European Journal of Biochemistry
3451:10.1111/j.1471-4159.2004.02797.x
2829:European Journal of Biochemistry
2775:10.1146/annurev.biochem.68.1.355
2073:aromatic amino acid hydroxylases
1985:Tyrosine hydroxylase in red and
1569:aromatic amino acid hydroxylases
816:epinephrine biosynthetic process
555:
317:
310:
304:
281:
216:
209:
203:
178:
27:
7589:Tooltip Histidine decarboxylase
5848:Cholesterol 7 alpha-hydroxylase
5794:Flavin-containing monooxygenase
2197:leads to impaired synthesis of
2195:Tyrosine hydroxylase deficiency
2121:extracellular regulated kinases
2048:, which has no clearly defined
1567:together make up the family of
966:response to electrical stimulus
776:regulation of heart contraction
669:protein domain specific binding
7466:Tooltip Tryptophan hydroxylase
7246:Norepinephrine (noradrenaline)
7180:Norepinephrine (Noradrenaline)
6605:Norepinephrine (noradrenaline)
6569:Tooltip Aldehyde dehydrogenase
4528:Cytogenetics and Cell Genetics
3049:Journal of Neural Transmission
2174:increase tyrosine hydroxylase
1918:of all cells containing these
986:response to lipopolysaccharide
921:sphingolipid metabolic process
566:More reference expression data
535:More reference expression data
1:
7792:Monoamine reuptake inhibitors
7772:Receptor/signaling modulators
5414:Catechol-O-methyl transferase
5329:Histamine N-methyltransferase
4854:10.1016/S0021-9258(18)89798-8
4820:10.1016/S0006-291X(88)81022-2
4760:10.1016/S0021-9258(18)68656-9
4510:10.1016/S0021-9258(19)38451-0
4090:10.1016/s0920-9964(96)00118-1
3811:10.1016/S0021-9258(18)42325-3
3687:Journal of Biomedical Science
3321:10.1016/S0021-9258(19)38451-0
2763:Annual Review of Biochemistry
2734:10.1016/S0021-9258(18)93832-9
2109:cAMP-dependent protein kinase
1828:-3,4-dihydroxyphenylalanine (
1051:response to water deprivation
1006:phytoalexin metabolic process
956:cellular response to alkaloid
951:cellular response to nicotine
941:dopamine biosynthetic process
302:
201:
7843:Genes on human chromosome 11
7092:Tooltip Tyrosine hydroxylase
5488:4-aminobutyrate transaminase
4615:10.1016/0006-291X(87)90742-X
4133:10.1016/j.semcdb.2011.08.005
2292:dopamine-responsive dystonia
2271:A consistent abnormality in
2123:1&2), and increases the
1081:fatty acid metabolic process
971:response to isolation stress
831:multicellular organism aging
755:cytoplasmic vesicle membrane
745:smooth endoplasmic reticulum
7752:Pimagedine (aminoguanidine)
7622:Alpha-Fluoromethylhistidine
6077:Deoxyhypusine monooxygenase
2593:Current Medicinal Chemistry
2221:, extrapyramidal symptoms,
1498:-3,4-dihydroxyphenylalanine
1066:response to peptide hormone
991:cerebral cortex development
976:glycoside metabolic process
896:response to nutrient levels
856:phthalate metabolic process
786:response to steroid hormone
599:tetrahydrobiopterin binding
7864:
7796:Monoamine releasing agents
6562:Substrates→Products (with
4288:10.7164/antibiotics.21.350
4275:The Journal of Antibiotics
2605:10.2174/092986707779941023
2256:, Parkinson's disease and
1999:Tyrosine hydroxylase is a
1877:dihydropteridine reductase
946:response to corticosterone
866:response to light stimulus
836:animal organ morphogenesis
826:circadian sleep/wake cycle
485:superior cervical ganglion
7764:
6910:
6785:
6557:
6550:Tooltip Monoamine oxidase
6266:Michaelis–Menten kinetics
6072:Ecdysone 20-monooxygenase
6023:Stearoyl-CoA desaturase-1
5995:Dopamine beta-hydroxylase
5963:Phenylalanine hydroxylase
5609:Choline acetyltransferase
5527:-amino acid decarboxylase
5389:Dopamine beta-hydroxylase
5384:-amino acid decarboxylase
5076:
4706:Journal of Neurochemistry
4157:Journal of Neurochemistry
3923:Journal of Neurochemistry
3887:10.1016/j.cub.2006.01.017
3654:10.1016/j.abb.2004.11.007
3438:Journal of Neurochemistry
3345:Journal of Neurochemistry
3131:Nature Structural Biology
3061:10.1007/s00702-009-0227-8
2977:10.1016/j.abb.2010.12.017
2869:Journal of Neurochemistry
2640:10.1042/0264-6021:3470001
2469:10.1002/9780470123164.ch3
2442:"Mouse PubMed Reference:"
2424:"Human PubMed Reference:"
2062:phenylalanine hydroxylase
1832:-DOPA). The enzyme is an
1757:
1586:
1561:phenylalanine hydroxylase
1528:-DOPA is a precursor for
1504:-DOPA). It does so using
1459:
1454:
1450:
1443:
1427:
1421:Chr 7: 142.45 – 142.48 Mb
1408:
1393:
1356:
1345:
1330:
1301:
1290:
1277:
1273:
1254:
1250:
1241:
1228:
1224:
1209:
1205:
1196:
1183:
1179:
1164:
1160:
1151:
1136:
1129:
1125:
1109:
841:response to growth factor
806:terpene metabolic process
584:
580:
563:
554:
545:
532:
481:
472:
419:
410:
380:
372:
368:
351:
338:
301:
280:
271:
267:
250:
237:
200:
177:
168:
164:
119:
116:
106:
99:
94:
71:
66:
49:
44:
39:
35:
26:
21:
7250:Epinephrine (adrenaline)
6583:Epinephrine (adrenaline)
6158:Diffusion-limited enzyme
5035:Medical Subject Headings
4991:Human Molecular Genetics
3980:10.1177/0883073807302619
2690:10.1074/jbc.271.40.24395
1991:EnCor Biotechnology Inc.
1582:tyrosine 3-monooxygenase
1559:. Tyrosine hydroxylase,
1477:tyrosine 3-monooxygenase
7727:Tooltip Diamine oxidase
5468:Glutamate decarboxylase
5309:Histidine decarboxylase
4779:Journal of Biochemistry
4491:Haycock JW (Jul 1990).
4412:10.1073/pnas.75.10.4744
4318:. 53–54 (1–2): 129–52.
3760:10.1074/jbc.M109.027706
3608:10.1073/pnas.85.19.7084
3302:Haycock JW (Jul 1990).
3270:10.1073/pnas.84.16.5530
3011:Journal of Biochemistry
2632:The Biochemical Journal
2311:reactive oxygen species
1937:-phenylalanine to form
1091:response to insecticide
791:response to amphetamine
781:response to salt stress
639:oxidoreductase activity
517:external carotid artery
7627:Histidine methyl ester
6057:Squalene monooxygenase
5973:Tryptophan hydroxylase
5722:HIF prolyl-hydroxylase
5518:Tryptophan hydroxylase
4648:10.1093/nar/15.16.6733
4636:Nucleic Acids Research
4465:10.1073/pnas.89.6.2365
4350:Molecular Neurobiology
4213:10.1006/bbrc.1999.1945
4078:Schizophrenia Research
3549:10.1073/pnas.89.6.2365
3405:10.1074/jbc.M512194200
2928:10.1002/pro.5560041013
2634:. 347 Pt 1 (1): 1–16.
2547:Molecular Neurobiology
2507:Essays in Biochemistry
2092:
2066:tryptophan hydroxylase
1993:
1978:
1908:dopamine β-hydroxylase
1812:the reaction in which
1565:tryptophan hydroxylase
1553:central nervous system
1414:Chr 11: 2.16 – 2.17 Mb
996:response to pyrethroid
664:monooxygenase activity
497:lumbar spinal ganglion
489:ventral tegmental area
7800:Monoamine neurotoxins
7742:Imidazole acetic acid
6251:Eadie–Hofstee diagram
6184:Allosteric regulation
5853:Methane monooxygenase
5826:Nitric oxide synthase
5637:Butyrylcholinesterase
5563:Nitric oxide synthase
5156:Non-heme iron protein
4362:10.1385/MN:26:2-3:389
2190:Clinical significance
2086:
2058:X-ray crystallography
1987:serotonin transporter
1984:
1968:
1808:Tyrosine hydroxylase
1021:response to estradiol
1011:response to herbicide
881:response to metal ion
194:Chromosome 11 (human)
7735:Substrates→Products:
7665:Substrates→Products:
7597:Substrates→Products:
7554:Substrates→Products:
7524:Substrates→Products:
7474:Substrates→Products:
7293:Substrates→Products:
7243:Substrates→Products:
7173:Substrates→Products:
7100:Substrates→Products:
7077:3,4-Dihydroxystyrene
7060:Substrates→Products:
6444:Substrates→Products:
6261:Lineweaver–Burk plot
5968:Tyrosine hydroxylase
5692:steroid hydroxylases
5633:Acetylcholinesterase
5375:Tyrosine hydroxylase
5223:Tyrosine hydroxylase
5031:Tyrosine+hydroxylase
5003:10.1093/hmg/4.7.1209
2258:Huntington's disease
2054:secondary structures
2042:alternative splicing
1879:(DHPR) converts q-BH
1536:(noradrenaline) and
1473:Tyrosine hydroxylase
1076:response to activity
876:response to nicotine
801:response to zinc ion
614:ferrous iron binding
335:7 F5|7 88.06 cM
296:Chromosome 7 (mouse)
67:List of PDB id codes
40:Available structures
7215:Phenopicolinic acid
6939:Desmethylselegiline
5918:iron–sulfur protein
5213:Iron–sulfur protein
4884:1995Natur.374..640Z
4688:10.1021/bi00396a007
4569:1987Natur.326..707G
4456:1992PNAS...89.2365H
4403:1978PNAS...75.4744J
4248:10.1021/ja00734a054
4029:10.3390/jpm11111186
3599:1988PNAS...85.7084I
3540:1992PNAS...89.2365H
3261:1987PNAS...84.5530G
3222:10.1021/bi00335a001
3143:10.1038/nsb0797-578
2810:10.1021/ja00082a046
2353:and also resistant
2273:Parkinson's disease
2254:Alzheimer's disease
2246:Parkinson's disease
1957:-DOPA derivatives.
1846:tetrahydrobiopterin
1824:position to obtain
1518:tetrahydrobiopterin
1046:heart morphogenesis
1026:response to hypoxia
861:locomotory behavior
846:response to ethanol
760:cytoplasmic vesicle
720:melanosome membrane
649:ferric iron binding
459:right lobe of liver
447:left adrenal cortex
435:right adrenal gland
7391:2-Hydroxyestradiol
7372:4-Methoxyestradiol
7368:4-Hydroxyestradiol
7354:2-Methoxyestradiol
7350:2-Hydroxyestradiol
7120:2-Hydroxyestradiol
6220:Enzyme superfamily
6153:Enzyme promiscuity
5717:Prolyl hydroxylase
5208:Inositol oxygenase
4966:10.1007/BF00225091
4929:10.1007/BF00209496
4324:10.1007/BF00225250
4062:"Patient registry"
3693:(6 Pt 2): 774–81.
2559:10.1007/BF02741387
2093:
2050:tertiary structure
2003:of four identical
1994:
1979:
1945:-tyrosine to form
1924:rate limiting step
1904:DOPA decarboxylase
1231:ENSMUSG00000000214
769:Biological process
740:neuronal cell body
678:Cellular component
659:amino acid binding
592:Molecular function
443:left adrenal gland
7808:
7807:
7803:
7760:
7759:
7672:N-Methylhistamine
7602:
7569:
7568:
7557:N-Acetylserotonin
7531:N-Acetylserotonin
7501:Telotristat ethyl
7496:Fenclonine (PCPA)
7453:
7434:
7433:
7309:Homovanillic acid
7300:3-Methoxytyramine
7109:
7039:
7015:
7014:
7011:
7010:
6992:
6933:
6861:tetrahydroharmine
6841:Harmala alkaloids
6636:3-Methoxytyramine
6491:
6470:
6449:
6376:
6375:
6085:
6084:
5751:Lysyl hydroxylase
5650:
5649:
5646:
5645:
5545:
5544:
5526:
5496:
5495:
5439:
5438:
5419:Monoamine oxidase
5383:
5342:
5341:
5269:neurotransmission
5231:
5230:
5114:
5113:
4540:10.1159/000132246
3847:10.1021/bi980582l
3699:10.1159/000073965
3187:10.1021/bi981462g
3105:10.1021/bi7019468
2683:(40): 24395–400.
2478:978-0-470-12316-4
2348:
2342:
2328:
2317:
2283:
2242:Segawa's dystonia
2184:protein synthesis
2168:second messengers
2028:residues and one
2017:carboxyl terminal
1977:would enter from.
1956:
1952:
1948:
1944:
1940:
1936:
1913:
1901:
1843:
1831:
1827:
1815:
1806:
1805:
1802:
1801:
1705:metabolic pathway
1601:
1527:
1503:
1497:
1490:
1470:
1469:
1466:
1465:
1439:
1438:
1404:
1403:
1383:
1382:
1341:
1340:
1320:
1319:
1286:
1285:
1267:
1266:
1237:
1236:
1218:
1217:
1192:
1191:
1173:
1172:
1121:
1120:
1016:visual perception
916:response to ether
891:heart development
700:neuron projection
624:metal ion binding
576:
575:
572:
571:
541:
540:
528:
527:
466:
465:
364:
363:
263:
262:
90:
89:
86:
85:
50:Ortholog search:
7855:
7825:
7824:
7816:
7766:
7728:
7724:
7658:
7654:
7600:
7590:
7586:
7580:
7547:
7543:
7517:
7513:
7467:
7463:
7457:
7443:
7396:2-Hydroxyestrone
7381:4-Methoxyestrone
7377:4-Hydroxyestrone
7363:2-Methoxyestrone
7359:2-Hydroxyestrone
7286:
7282:
7236:
7232:
7166:
7162:
7125:2-Hydroxyestrone
7110:-DOPA (levodopa)
7107:
7093:
7089:
7053:
7049:
7043:
7024:
6990:
6931:
6918:MAO-B selective:
6793:MAO-A-selective:
6757:Phenoxypropazine
6579:
6575:
6570:
6566:
6555:
6551:
6547:
6489:
6468:
6450:-DOPA (levodopa)
6447:
6437:
6433:
6427:
6403:
6396:
6389:
6380:
6256:Hanes–Woolf plot
6199:Enzyme activator
6194:Enzyme inhibitor
6168:Enzyme catalysis
6112:
6105:
6098:
6089:
5677:
5670:
5663:
5654:
5622:
5602:
5595:
5524:
5481:
5461:
5454:
5407:
5381:
5368:
5361:
5322:
5302:
5295:
5282:
5258:
5251:
5244:
5235:
5175:Bacterioferritin
5148:Carrier proteins
5141:
5134:
5127:
5118:
5100:
5085:
5065:
5058:
5051:
5042:
5014:
4985:
4948:
4911:
4892:10.1038/374640a0
4866:
4856:
4831:
4802:
4772:
4762:
4737:
4699:
4669:
4659:
4626:
4596:
4577:10.1038/326707a0
4563:(6114): 707–11.
4551:
4522:
4512:
4503:(20): 11682–91.
4487:
4477:
4467:
4434:
4424:
4414:
4381:
4356:(2–3): 389–403.
4343:
4301:
4300:
4290:
4266:
4260:
4259:
4231:
4225:
4224:
4195:
4189:
4188:
4151:
4145:
4144:
4116:
4110:
4109:
4072:
4066:
4065:
4058:
4052:
4051:
4041:
4031:
4006:
4000:
3999:
3961:
3955:
3954:
3917:
3908:
3907:
3889:
3865:
3859:
3858:
3830:
3824:
3823:
3813:
3804:(18): 12639–46.
3789:
3783:
3782:
3772:
3762:
3753:(47): 32758–69.
3738:
3729:
3728:
3710:
3684:
3675:
3666:
3665:
3637:
3631:
3630:
3620:
3610:
3578:
3572:
3571:
3561:
3551:
3519:
3513:
3512:
3502:
3478:
3472:
3471:
3453:
3429:
3418:
3417:
3407:
3398:(26): 17644–51.
3383:
3377:
3376:
3340:
3334:
3333:
3323:
3314:(20): 11682–91.
3299:
3293:
3292:
3282:
3272:
3240:
3234:
3233:
3205:
3199:
3198:
3181:(39): 13437–45.
3169:
3163:
3162:
3126:
3117:
3116:
3087:
3081:
3080:
3044:
3035:
3034:
3005:
2999:
2998:
2988:
2956:
2950:
2949:
2939:
2907:
2901:
2900:
2861:
2855:
2854:
2844:
2820:
2814:
2813:
2804:(3): 1133–1134.
2793:
2787:
2786:
2758:
2747:
2746:
2736:
2712:
2703:
2702:
2692:
2668:
2662:
2661:
2651:
2623:
2617:
2616:
2588:
2579:
2578:
2542:
2523:
2522:
2502:
2491:
2490:
2456:
2450:
2449:
2438:
2432:
2431:
2420:
2414:
2404:
2393:
2383:
2351:pheochromocytoma
2346:
2344:
2340:
2330:
2326:
2319:
2315:
2285:
2281:
2277:substantia nigra
2149:substantia nigra
1954:
1950:
1946:
1942:
1938:
1934:
1911:
1899:
1841:
1829:
1825:
1813:
1759:
1599:
1591:
1579:
1525:
1506:molecular oxygen
1501:
1495:
1488:
1452:
1451:
1423:
1416:
1399:
1387:
1378:
1350:
1346:RefSeq (protein)
1336:
1324:
1315:
1295:
1271:
1248:
1222:
1203:
1177:
1158:
1127:
715:synaptic vesicle
644:iron ion binding
629:dopamine binding
582:
568:
559:
552:
537:
513:substantia nigra
509:thoracic ganglia
505:secondary oocyte
477:
475:Top expressed in
470:
415:
413:Top expressed in
408:
387:
370:
360:
347:
336:
321:
314:
308:
297:
285:
269:
259:
246:
235:
220:
213:
207:
196:
182:
166:
160:
111:
104:
81:
64:
58:
37:
36:
31:
19:
7863:
7862:
7858:
7857:
7856:
7854:
7853:
7852:
7833:
7832:
7831:
7819:
7811:
7809:
7804:
7756:
7726:
7716:
7687:Diphenhydramine
7656:
7646:
7588:
7565:
7545:
7535:
7515:
7505:
7465:
7442:
7430:
7318:Normetanephrine
7284:
7274:
7234:
7224:
7164:
7154:
7091:
7081:
7051:
7034:
7023:
7021:Phenethylamines
7007:
6906:
6781:
6777:Tranylcypromine
6614:Normetanephrine
6577:
6568:
6549:
6539:
6435:
6418:
6407:
6377:
6372:
6284:Oxidoreductases
6270:
6246:Enzyme kinetics
6234:
6230:List of enzymes
6203:
6172:
6143:Catalytic triad
6121:
6116:
6086:
6081:
6035:- miscellaneous
6027:
5999:
5977:
5940:
5908:
5872:
5863:14α-demethylase
5772:
5699:
5684:Oxidoreductases
5681:
5651:
5642:
5618:
5613:
5598:
5580:
5541:
5492:
5477:
5472:
5457:
5435:
5403:
5398:
5364:
5338:
5334:Diamine oxidase
5318:
5313:
5298:
5271:
5262:
5232:
5227:
5191:
5158:
5152:metalloproteins
5145:
5115:
5110:
5107:
5101:
5092:
5086:
5072:
5069:
5022:
5017:
4988:
4951:
4914:
4878:(6523): 640–3.
4869:
4847:(22): 13680–3.
4834:
4805:
4775:
4753:(15): 7406–10.
4740:
4702:
4672:
4629:
4599:
4554:
4525:
4490:
4437:
4384:
4346:
4313:
4309:
4307:Further reading
4304:
4268:
4267:
4263:
4233:
4232:
4228:
4197:
4196:
4192:
4153:
4152:
4148:
4118:
4117:
4113:
4074:
4073:
4069:
4060:
4059:
4055:
4008:
4007:
4003:
3963:
3962:
3958:
3919:
3918:
3911:
3874:Current Biology
3867:
3866:
3862:
3832:
3831:
3827:
3791:
3790:
3786:
3740:
3739:
3732:
3682:
3677:
3676:
3669:
3639:
3638:
3634:
3580:
3579:
3575:
3521:
3520:
3516:
3480:
3479:
3475:
3431:
3430:
3421:
3385:
3384:
3380:
3342:
3341:
3337:
3301:
3300:
3296:
3242:
3241:
3237:
3216:(14): 3389–94.
3207:
3206:
3202:
3171:
3170:
3166:
3128:
3127:
3120:
3089:
3088:
3084:
3055:(11): 1355–62.
3046:
3045:
3038:
3007:
3006:
3002:
2958:
2957:
2953:
2916:Protein Science
2909:
2908:
2904:
2863:
2862:
2858:
2822:
2821:
2817:
2795:
2794:
2790:
2760:
2759:
2750:
2714:
2713:
2706:
2670:
2669:
2665:
2625:
2624:
2620:
2590:
2589:
2582:
2544:
2543:
2526:
2504:
2503:
2494:
2479:
2458:
2457:
2453:
2440:
2439:
2435:
2422:
2421:
2417:
2405:
2396:
2384:
2375:
2371:
2339:
2325:
2314:
2307:
2303:
2280:
2229:, and postural
2192:
2162:), drugs (e.g.
2160:glucocorticoids
2130:14-3-3 proteins
2125:enzyme activity
2105:protein kinases
2097:phosphorylation
2081:
1963:
1893:oxidation state
1886:
1882:
1874:
1866:
1862:
1858:
1851:
1839:
1612:
1611:
1607:
1577:
1557:adrenal medulla
1511:
1461:View/Edit Mouse
1456:View/Edit Human
1419:
1412:
1409:Location (UCSC)
1395:
1374:
1370:
1366:
1362:
1358:
1332:
1311:
1307:
1303:
1259:
1212:ENSG00000180176
1105:
1036:eating behavior
961:mating behavior
906:social behavior
764:
725:terminal bouton
673:
654:protein binding
564:
533:
524:
519:
515:
511:
507:
503:
499:
495:
491:
487:
473:
462:
457:
455:caudate nucleus
453:
449:
445:
441:
437:
433:
429:
425:
423:pars reticulata
411:
355:
342:
334:
324:
323:
322:
315:
295:
272:Gene location (
254:
241:
233:
223:
222:
221:
214:
192:
169:Gene location (
120:
107:
100:
73:
51:
17:
12:
11:
5:
7861:
7859:
7851:
7850:
7845:
7835:
7834:
7830:
7829:
7806:
7805:
7765:
7762:
7761:
7758:
7757:
7755:
7754:
7745:
7744:
7731:
7729:
7718:
7717:
7715:
7714:
7709:
7704:
7699:
7694:
7689:
7684:
7675:
7674:
7661:
7659:
7648:
7647:
7645:
7644:
7639:
7634:
7629:
7624:
7619:
7610:
7609:
7593:
7591:
7577:
7571:
7570:
7567:
7566:
7564:
7563:
7550:
7548:
7537:
7536:
7534:
7533:
7520:
7518:
7507:
7506:
7504:
7503:
7498:
7493:
7484:
7483:
7470:
7468:
7454:
7436:
7435:
7432:
7431:
7429:
7428:
7423:
7418:
7413:
7408:
7403:
7398:
7393:
7384:
7383:
7374:
7365:
7356:
7347:
7338:
7329:
7320:
7314:Norepinephrine
7311:
7302:
7289:
7287:
7276:
7275:
7273:
7272:
7267:
7262:
7253:
7252:
7239:
7237:
7226:
7225:
7223:
7222:
7217:
7212:
7207:
7202:
7197:
7192:
7183:
7182:
7169:
7167:
7156:
7155:
7153:
7152:
7147:
7142:
7137:
7132:
7130:3-Iodotyrosine
7127:
7122:
7113:
7112:
7096:
7094:
7083:
7082:
7080:
7079:
7070:
7069:
7056:
7054:
7040:
7036:norepinephrine
7017:
7016:
7013:
7012:
7009:
7008:
7006:
7005:
7000:
6995:
6986:
6981:
6976:
6971:
6966:
6961:
6956:
6951:
6946:
6941:
6936:
6928:
6923:
6911:
6908:
6907:
6905:
6904:
6899:
6894:
6889:
6884:
6879:
6874:
6869:
6867:Methylene blue
6864:
6838:
6833:
6828:
6826:CX157 (Tyrima)
6823:
6818:
6813:
6808:
6803:
6798:
6786:
6783:
6782:
6780:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6699:
6694:
6689:
6684:
6679:
6674:
6669:
6664:
6659:Non-selective:
6652:
6651:
6642:
6633:
6624:
6611:
6602:
6589:
6558:
6552:
6541:
6540:
6538:
6537:
6532:
6527:
6522:
6517:
6508:
6507:
6498:
6486:
6484:Phenethylamine
6477:
6465:
6456:
6440:
6438:
6424:
6420:
6419:
6408:
6406:
6405:
6398:
6391:
6383:
6374:
6373:
6371:
6370:
6357:
6344:
6331:
6318:
6305:
6292:
6278:
6276:
6272:
6271:
6269:
6268:
6263:
6258:
6253:
6248:
6242:
6240:
6236:
6235:
6233:
6232:
6227:
6222:
6217:
6211:
6209:
6208:Classification
6205:
6204:
6202:
6201:
6196:
6191:
6186:
6180:
6178:
6174:
6173:
6171:
6170:
6165:
6160:
6155:
6150:
6145:
6140:
6135:
6129:
6127:
6123:
6122:
6117:
6115:
6114:
6107:
6100:
6092:
6083:
6082:
6080:
6079:
6074:
6069:
6064:
6059:
6054:
6047:Heme oxygenase
6044:
6042:Cyclooxygenase
6038:
6036:
6029:
6028:
6026:
6025:
6020:
6014:
6012:
6001:
6000:
5998:
5997:
5991:
5989:
5979:
5978:
5976:
5975:
5970:
5965:
5959:
5957:
5942:
5941:
5939:
5938:
5933:
5928:
5922:
5920:
5910:
5909:
5907:
5906:
5901:
5896:
5890:
5888:
5874:
5873:
5871:
5870:
5865:
5860:
5855:
5850:
5845:
5844:
5843:
5838:
5833:
5823:
5822:
5821:
5816:
5811:
5806:
5801:
5790:
5788:
5774:
5773:
5771:
5770:
5769:
5768:
5763:
5753:
5748:
5747:
5746:
5741:
5740:
5739:
5734:
5729:
5713:
5711:
5709:2-oxoglutarate
5701:
5700:
5682:
5680:
5679:
5672:
5665:
5657:
5648:
5647:
5644:
5643:
5641:
5640:
5629:Cholinesterase
5625:
5623:
5615:
5614:
5612:
5611:
5605:
5603:
5592:
5582:
5581:
5579:
5578:
5559:
5557:
5547:
5546:
5543:
5542:
5540:
5539:
5534:
5529:
5520:
5514:
5512:
5498:
5497:
5494:
5493:
5491:
5490:
5484:
5482:
5474:
5473:
5471:
5470:
5464:
5462:
5451:
5441:
5440:
5437:
5436:
5434:
5433:
5432:
5431:
5426:
5416:
5410:
5408:
5400:
5399:
5397:
5396:
5391:
5386:
5377:
5371:
5369:
5358:
5344:
5343:
5340:
5339:
5337:
5336:
5331:
5325:
5323:
5315:
5314:
5312:
5311:
5305:
5303:
5292:
5279:
5273:
5272:
5263:
5261:
5260:
5253:
5246:
5238:
5229:
5228:
5226:
5225:
5220:
5215:
5210:
5205:
5199:
5197:
5193:
5192:
5190:
5189:
5184:
5179:
5178:
5177:
5166:
5164:
5160:
5159:
5146:
5144:
5143:
5136:
5129:
5121:
5112:
5111:
5109:
5108:
5102:
5095:
5093:
5087:
5080:
5077:
5074:
5073:
5070:
5068:
5067:
5060:
5053:
5045:
5039:
5038:
5028:
5021:
5020:External links
5018:
5016:
5015:
4997:(7): 1209–12.
4986:
4954:Human Genetics
4949:
4917:Human Genetics
4912:
4867:
4832:
4803:
4773:
4738:
4700:
4682:(22): 6910–4.
4670:
4627:
4597:
4552:
4534:(1–2): 29–32.
4523:
4488:
4435:
4397:(10): 4744–8.
4382:
4344:
4310:
4308:
4305:
4303:
4302:
4261:
4226:
4190:
4146:
4127:(7): 696–704.
4111:
4067:
4053:
4022:(1186): 1186.
4001:
3974:(5): 606–616.
3967:J Child Neurol
3956:
3909:
3860:
3841:(25): 8980–6.
3825:
3784:
3730:
3667:
3632:
3593:(19): 7084–8.
3573:
3514:
3473:
3444:(5): 1025–43.
3419:
3378:
3335:
3294:
3255:(16): 5530–4.
3235:
3200:
3164:
3118:
3099:(6): 1768–77.
3082:
3036:
3000:
2951:
2922:(10): 2082–6.
2902:
2875:(6): 2014–20.
2856:
2815:
2788:
2748:
2704:
2663:
2618:
2580:
2553:(3): 285–309.
2524:
2492:
2477:
2451:
2433:
2415:
2394:
2372:
2370:
2367:
2305:
2301:
2211:encephalopathy
2207:norepinephrine
2191:
2188:
2080:
2077:
2034:amino terminal
1962:
1959:
1920:catecholamines
1884:
1880:
1872:
1864:
1860:
1856:
1849:
1837:
1804:
1803:
1800:
1799:
1794:
1788:
1787:
1782:
1776:
1775:
1770:
1764:
1763:
1755:
1754:
1745:
1739:
1738:
1727:
1720:
1719:
1714:
1708:
1707:
1702:
1696:
1695:
1690:
1684:
1683:
1678:
1672:
1671:
1666:
1660:
1659:
1654:
1648:
1647:
1643:
1642:
1637:
1631:
1630:
1625:
1619:
1618:
1614:
1613:
1609:
1605:
1592:
1584:
1583:
1576:
1573:
1542:catecholamines
1534:norepinephrine
1512:), as well as
1509:
1468:
1467:
1464:
1463:
1458:
1448:
1447:
1441:
1440:
1437:
1436:
1434:
1432:
1425:
1424:
1417:
1410:
1406:
1405:
1402:
1401:
1391:
1390:
1384:
1381:
1380:
1354:
1353:
1347:
1343:
1342:
1339:
1338:
1328:
1327:
1321:
1318:
1317:
1299:
1298:
1292:
1288:
1287:
1284:
1283:
1275:
1274:
1268:
1265:
1264:
1252:
1251:
1245:
1239:
1238:
1235:
1234:
1226:
1225:
1219:
1216:
1215:
1207:
1206:
1200:
1194:
1193:
1190:
1189:
1181:
1180:
1174:
1171:
1170:
1162:
1161:
1155:
1149:
1148:
1143:
1138:
1134:
1133:
1123:
1122:
1119:
1118:
1107:
1106:
1104:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
772:
770:
766:
765:
763:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
651:
646:
641:
636:
634:enzyme binding
631:
626:
621:
619:oxygen binding
616:
611:
606:
601:
595:
593:
589:
588:
578:
577:
574:
573:
570:
569:
561:
560:
549:
543:
542:
539:
538:
530:
529:
526:
525:
523:
522:
521:olfactory bulb
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
479:
478:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
404:
403:
395:
384:
378:
377:
374:RNA expression
366:
365:
362:
361:
353:
349:
348:
340:
337:
332:
326:
325:
316:
309:
303:
299:
298:
293:
287:
286:
278:
277:
265:
264:
261:
260:
252:
248:
247:
239:
236:
231:
225:
224:
215:
208:
202:
198:
197:
190:
184:
183:
175:
174:
162:
161:
158:TH - orthologs
118:
114:
113:
105:
97:
96:
92:
91:
88:
87:
84:
83:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
7860:
7849:
7846:
7844:
7841:
7840:
7838:
7828:
7823:
7818:
7814:
7802:
7801:
7797:
7793:
7789:
7788:Serotonergics
7785:
7784:Melatonergics
7781:
7780:Dopaminergics
7777:
7773:
7770:
7763:
7753:
7750:
7747:
7746:
7743:
7739:
7736:
7733:
7732:
7730:
7725:
7719:
7713:
7710:
7708:
7705:
7703:
7700:
7698:
7695:
7693:
7690:
7688:
7685:
7683:
7680:
7677:
7676:
7673:
7669:
7666:
7663:
7662:
7660:
7655:
7649:
7643:
7640:
7638:
7635:
7633:
7630:
7628:
7625:
7623:
7620:
7618:
7615:
7612:
7611:
7608:
7604:
7598:
7595:
7594:
7592:
7587:
7581:
7578:
7576:
7572:
7562:
7558:
7555:
7552:
7551:
7549:
7544:
7538:
7532:
7528:
7525:
7522:
7521:
7519:
7514:
7508:
7502:
7499:
7497:
7494:
7492:
7489:
7486:
7485:
7482:
7478:
7475:
7472:
7471:
7469:
7464:
7458:
7455:
7451:
7447:
7441:
7437:
7427:
7424:
7422:
7419:
7417:
7414:
7412:
7409:
7407:
7404:
7402:
7399:
7397:
7394:
7392:
7389:
7386:
7385:
7382:
7378:
7375:
7373:
7369:
7366:
7364:
7360:
7357:
7355:
7351:
7348:
7346:
7342:
7339:
7337:
7333:
7330:
7328:
7324:
7321:
7319:
7315:
7312:
7310:
7306:
7303:
7301:
7297:
7294:
7291:
7290:
7288:
7283:
7277:
7271:
7268:
7266:
7263:
7261:
7258:
7255:
7254:
7251:
7247:
7244:
7241:
7240:
7238:
7233:
7227:
7221:
7218:
7216:
7213:
7211:
7208:
7206:
7203:
7201:
7198:
7196:
7193:
7191:
7188:
7185:
7184:
7181:
7177:
7174:
7171:
7170:
7168:
7163:
7157:
7151:
7148:
7146:
7143:
7141:
7138:
7136:
7133:
7131:
7128:
7126:
7123:
7121:
7118:
7115:
7114:
7111:
7104:
7101:
7098:
7097:
7095:
7090:
7084:
7078:
7075:
7072:
7071:
7068:
7064:
7063:Phenylalanine
7061:
7058:
7057:
7055:
7050:
7044:
7041:
7037:
7032:
7028:
7022:
7018:
7004:
7001:
6999:
6996:
6994:
6987:
6985:
6982:
6980:
6977:
6975:
6972:
6970:
6967:
6965:
6962:
6960:
6957:
6955:
6952:
6950:
6947:
6945:
6942:
6940:
6937:
6935:
6929:
6927:
6924:
6922:
6919:
6916:
6913:
6912:
6909:
6903:
6900:
6898:
6895:
6893:
6890:
6888:
6885:
6883:
6880:
6878:
6875:
6873:
6870:
6868:
6865:
6862:
6858:
6854:
6850:
6846:
6842:
6839:
6837:
6834:
6832:
6829:
6827:
6824:
6822:
6819:
6817:
6814:
6812:
6809:
6807:
6804:
6802:
6799:
6797:
6794:
6791:
6788:
6787:
6784:
6778:
6775:
6773:
6770:
6768:
6765:
6763:
6760:
6758:
6755:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6733:
6730:
6728:
6727:Metfendrazine
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6708:
6707:Isocarboxazid
6705:
6703:
6700:
6698:
6695:
6693:
6690:
6688:
6685:
6683:
6680:
6678:
6675:
6673:
6672:Echinopsidine
6670:
6668:
6665:
6663:
6660:
6657:
6654:
6653:
6650:
6646:
6643:
6641:
6637:
6634:
6632:
6628:
6625:
6623:
6619:
6615:
6612:
6610:
6606:
6603:
6601:
6597:
6593:
6590:
6588:
6584:
6581:
6576:
6567:
6560:
6559:
6556:
6553:
6548:
6542:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6516:
6513:
6510:
6509:
6506:
6502:
6499:
6497:
6493:
6487:
6485:
6481:
6480:Phenylalanine
6478:
6476:
6472:
6466:
6464:
6460:
6457:
6455:
6451:
6445:
6442:
6441:
6439:
6434:
6428:
6425:
6421:
6417:
6414:
6411:
6404:
6399:
6397:
6392:
6390:
6385:
6384:
6381:
6368:
6364:
6363:
6358:
6355:
6351:
6350:
6345:
6342:
6338:
6337:
6332:
6329:
6325:
6324:
6319:
6316:
6312:
6311:
6306:
6303:
6299:
6298:
6293:
6290:
6286:
6285:
6280:
6279:
6277:
6273:
6267:
6264:
6262:
6259:
6257:
6254:
6252:
6249:
6247:
6244:
6243:
6241:
6237:
6231:
6228:
6226:
6225:Enzyme family
6223:
6221:
6218:
6216:
6213:
6212:
6210:
6206:
6200:
6197:
6195:
6192:
6190:
6189:Cooperativity
6187:
6185:
6182:
6181:
6179:
6175:
6169:
6166:
6164:
6161:
6159:
6156:
6154:
6151:
6149:
6148:Oxyanion hole
6146:
6144:
6141:
6139:
6136:
6134:
6131:
6130:
6128:
6124:
6120:
6113:
6108:
6106:
6101:
6099:
6094:
6093:
6090:
6078:
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6058:
6055:
6052:
6048:
6045:
6043:
6040:
6039:
6037:
6034:
6030:
6024:
6021:
6019:
6016:
6015:
6013:
6010:
6006:
6002:
5996:
5993:
5992:
5990:
5988:
5984:
5980:
5974:
5971:
5969:
5966:
5964:
5961:
5960:
5958:
5955:
5954:BH4 dependent
5951:
5947:
5943:
5937:
5934:
5932:
5929:
5927:
5924:
5923:
5921:
5919:
5915:
5911:
5905:
5902:
5900:
5897:
5895:
5892:
5891:
5889:
5887:
5883:
5879:
5875:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5842:
5839:
5837:
5834:
5832:
5829:
5828:
5827:
5824:
5820:
5817:
5815:
5812:
5810:
5807:
5805:
5802:
5800:
5797:
5796:
5795:
5792:
5791:
5789:
5787:
5783:
5779:
5775:
5767:
5764:
5762:
5759:
5758:
5757:
5754:
5752:
5749:
5745:
5742:
5738:
5735:
5733:
5730:
5728:
5725:
5724:
5723:
5720:
5719:
5718:
5715:
5714:
5712:
5710:
5706:
5702:
5697:
5693:
5689:
5685:
5678:
5673:
5671:
5666:
5664:
5659:
5658:
5655:
5638:
5634:
5630:
5627:
5626:
5624:
5621:
5616:
5610:
5607:
5606:
5604:
5601:
5596:
5593:
5591:
5590:Acetylcholine
5587:
5583:
5576:
5572:
5568:
5564:
5561:
5560:
5558:
5556:
5552:
5548:
5538:
5535:
5533:
5530:
5528:
5521:
5519:
5516:
5515:
5513:
5511:
5507:
5503:
5499:
5489:
5486:
5485:
5483:
5480:
5475:
5469:
5466:
5465:
5463:
5460:
5455:
5452:
5450:
5446:
5442:
5430:
5427:
5425:
5422:
5421:
5420:
5417:
5415:
5412:
5411:
5409:
5406:
5401:
5395:
5392:
5390:
5387:
5385:
5378:
5376:
5373:
5372:
5370:
5367:
5362:
5359:
5357:
5353:
5349:
5345:
5335:
5332:
5330:
5327:
5326:
5324:
5321:
5316:
5310:
5307:
5306:
5304:
5301:
5296:
5293:
5291:
5287:
5283:
5280:
5278:
5274:
5270:
5266:
5259:
5254:
5252:
5247:
5245:
5240:
5239:
5236:
5224:
5221:
5219:
5216:
5214:
5211:
5209:
5206:
5204:
5201:
5200:
5198:
5194:
5188:
5185:
5183:
5180:
5176:
5173:
5172:
5171:
5168:
5167:
5165:
5161:
5157:
5153:
5149:
5142:
5137:
5135:
5130:
5128:
5123:
5122:
5119:
5105:
5099:
5094:
5090:
5084:
5079:
5075:
5066:
5061:
5059:
5054:
5052:
5047:
5046:
5043:
5036:
5032:
5029:
5027:
5024:
5023:
5019:
5012:
5008:
5004:
5000:
4996:
4992:
4987:
4983:
4979:
4975:
4971:
4967:
4963:
4959:
4955:
4950:
4946:
4942:
4938:
4934:
4930:
4926:
4922:
4918:
4913:
4909:
4905:
4901:
4897:
4893:
4889:
4885:
4881:
4877:
4873:
4868:
4864:
4860:
4855:
4850:
4846:
4842:
4838:
4833:
4829:
4825:
4821:
4817:
4814:(3): 1341–7.
4813:
4809:
4804:
4800:
4796:
4792:
4788:
4785:(6): 907–12.
4784:
4780:
4774:
4770:
4766:
4761:
4756:
4752:
4748:
4744:
4739:
4735:
4731:
4727:
4723:
4719:
4715:
4712:(3): 988–91.
4711:
4707:
4701:
4697:
4693:
4689:
4685:
4681:
4677:
4671:
4667:
4663:
4658:
4653:
4649:
4645:
4641:
4637:
4633:
4628:
4624:
4620:
4616:
4612:
4608:
4604:
4598:
4594:
4590:
4586:
4582:
4578:
4574:
4570:
4566:
4562:
4558:
4553:
4549:
4545:
4541:
4537:
4533:
4529:
4524:
4520:
4516:
4511:
4506:
4502:
4498:
4494:
4489:
4485:
4481:
4476:
4471:
4466:
4461:
4457:
4453:
4450:(6): 2365–9.
4449:
4445:
4441:
4436:
4432:
4428:
4423:
4418:
4413:
4408:
4404:
4400:
4396:
4392:
4388:
4383:
4379:
4375:
4371:
4367:
4363:
4359:
4355:
4351:
4345:
4341:
4337:
4333:
4329:
4325:
4321:
4317:
4312:
4311:
4306:
4298:
4294:
4289:
4284:
4280:
4276:
4272:
4265:
4262:
4257:
4253:
4249:
4245:
4242:(5): 1285–6.
4241:
4237:
4230:
4227:
4222:
4218:
4214:
4210:
4207:(1): 456–61.
4206:
4202:
4194:
4191:
4186:
4182:
4178:
4174:
4170:
4166:
4162:
4158:
4150:
4147:
4142:
4138:
4134:
4130:
4126:
4122:
4115:
4112:
4107:
4103:
4099:
4095:
4091:
4087:
4084:(3): 259–64.
4083:
4079:
4071:
4068:
4063:
4057:
4054:
4049:
4045:
4040:
4035:
4030:
4025:
4021:
4018:
4017:
4016:J. Pers. Med.
4012:
4005:
4002:
3997:
3993:
3989:
3985:
3981:
3977:
3973:
3969:
3968:
3960:
3957:
3952:
3948:
3944:
3940:
3936:
3932:
3929:(2): 479–89.
3928:
3924:
3916:
3914:
3910:
3905:
3901:
3897:
3893:
3888:
3883:
3880:(4): 415–20.
3879:
3875:
3871:
3864:
3861:
3856:
3852:
3848:
3844:
3840:
3836:
3829:
3826:
3821:
3817:
3812:
3807:
3803:
3799:
3795:
3788:
3785:
3780:
3776:
3771:
3766:
3761:
3756:
3752:
3748:
3744:
3737:
3735:
3731:
3726:
3722:
3718:
3714:
3709:
3704:
3700:
3696:
3692:
3688:
3681:
3674:
3672:
3668:
3663:
3659:
3655:
3651:
3648:(2): 266–74.
3647:
3643:
3636:
3633:
3628:
3624:
3619:
3614:
3609:
3604:
3600:
3596:
3592:
3588:
3584:
3577:
3574:
3569:
3565:
3560:
3555:
3550:
3545:
3541:
3537:
3534:(6): 2365–9.
3533:
3529:
3525:
3518:
3515:
3510:
3506:
3501:
3496:
3493:(2): 715–22.
3492:
3488:
3484:
3477:
3474:
3469:
3465:
3461:
3457:
3452:
3447:
3443:
3439:
3435:
3428:
3426:
3424:
3420:
3415:
3411:
3406:
3401:
3397:
3393:
3389:
3382:
3379:
3374:
3370:
3366:
3362:
3358:
3354:
3351:(1): 236–42.
3350:
3346:
3339:
3336:
3331:
3327:
3322:
3317:
3313:
3309:
3305:
3298:
3295:
3290:
3286:
3281:
3276:
3271:
3266:
3262:
3258:
3254:
3250:
3246:
3239:
3236:
3231:
3227:
3223:
3219:
3215:
3211:
3204:
3201:
3196:
3192:
3188:
3184:
3180:
3176:
3168:
3165:
3160:
3156:
3152:
3148:
3144:
3140:
3137:(7): 578–85.
3136:
3132:
3125:
3123:
3119:
3114:
3110:
3106:
3102:
3098:
3094:
3086:
3083:
3078:
3074:
3070:
3066:
3062:
3058:
3054:
3050:
3043:
3041:
3037:
3032:
3028:
3024:
3020:
3017:(6): 907–12.
3016:
3012:
3004:
3001:
2996:
2992:
2987:
2982:
2978:
2974:
2970:
2966:
2962:
2955:
2952:
2947:
2943:
2938:
2933:
2929:
2925:
2921:
2917:
2913:
2906:
2903:
2898:
2894:
2890:
2886:
2882:
2878:
2874:
2870:
2866:
2860:
2857:
2852:
2848:
2843:
2838:
2834:
2830:
2826:
2819:
2816:
2811:
2807:
2803:
2799:
2792:
2789:
2784:
2780:
2776:
2772:
2768:
2764:
2757:
2755:
2753:
2749:
2744:
2740:
2735:
2730:
2726:
2722:
2718:
2711:
2709:
2705:
2700:
2696:
2691:
2686:
2682:
2678:
2674:
2667:
2664:
2659:
2655:
2650:
2645:
2641:
2637:
2633:
2629:
2622:
2619:
2614:
2610:
2606:
2602:
2599:(4): 455–67.
2598:
2594:
2587:
2585:
2581:
2576:
2572:
2568:
2564:
2560:
2556:
2552:
2548:
2541:
2539:
2537:
2535:
2533:
2531:
2529:
2525:
2520:
2516:
2512:
2508:
2501:
2499:
2497:
2493:
2488:
2484:
2480:
2474:
2470:
2466:
2462:
2455:
2452:
2447:
2443:
2437:
2434:
2429:
2425:
2419:
2416:
2412:
2408:
2403:
2401:
2399:
2395:
2391:
2387:
2382:
2380:
2378:
2374:
2368:
2366:
2364:
2360:
2356:
2352:
2337:
2332:
2323:
2312:
2308:
2297:
2294:. A direct
2293:
2289:
2278:
2274:
2269:
2267:
2263:
2259:
2255:
2251:
2250:schizophrenia
2247:
2243:
2238:
2236:
2232:
2228:
2224:
2220:
2216:
2212:
2208:
2204:
2200:
2196:
2189:
2187:
2185:
2181:
2177:
2176:transcription
2173:
2169:
2165:
2161:
2157:
2152:
2150:
2146:
2141:
2137:
2133:
2131:
2126:
2122:
2118:
2114:
2110:
2106:
2102:
2098:
2090:
2089:catecholamine
2085:
2078:
2076:
2074:
2071:
2067:
2063:
2059:
2055:
2051:
2047:
2043:
2039:
2035:
2031:
2027:
2022:
2018:
2014:
2010:
2006:
2002:
1997:
1992:
1988:
1983:
1976:
1972:
1967:
1960:
1958:
1932:
1927:
1925:
1921:
1917:
1909:
1905:
1896:
1894:
1890:
1878:
1870:
1853:
1847:
1835:
1823:
1819:
1816:-tyrosine is
1811:
1798:
1795:
1793:
1789:
1786:
1783:
1781:
1777:
1774:
1771:
1769:
1765:
1760:
1756:
1753:
1749:
1746:
1744:
1743:Gene Ontology
1740:
1737:
1734:
1731:
1728:
1725:
1721:
1718:
1715:
1713:
1709:
1706:
1703:
1701:
1697:
1694:
1691:
1689:
1685:
1682:
1681:NiceZyme view
1679:
1677:
1673:
1670:
1667:
1665:
1661:
1658:
1655:
1653:
1649:
1644:
1641:
1638:
1636:
1632:
1629:
1626:
1624:
1620:
1615:
1603:
1596:
1590:
1585:
1580:
1574:
1572:
1570:
1566:
1562:
1558:
1554:
1550:
1548:
1543:
1539:
1535:
1531:
1523:
1519:
1515:
1507:
1499:
1492:
1486:
1482:
1478:
1474:
1462:
1457:
1453:
1449:
1446:
1442:
1435:
1433:
1430:
1426:
1422:
1418:
1415:
1411:
1407:
1400:
1398:
1392:
1388:
1385:
1379:
1377:
1373:
1369:
1365:
1361:
1355:
1351:
1348:
1344:
1337:
1335:
1329:
1325:
1322:
1316:
1314:
1310:
1306:
1300:
1296:
1293:
1291:RefSeq (mRNA)
1289:
1282:
1281:
1276:
1272:
1269:
1263:
1262:
1258:
1253:
1249:
1246:
1244:
1240:
1233:
1232:
1227:
1223:
1220:
1214:
1213:
1208:
1204:
1201:
1199:
1195:
1188:
1187:
1182:
1178:
1175:
1169:
1168:
1163:
1159:
1156:
1154:
1150:
1147:
1144:
1142:
1139:
1135:
1132:
1128:
1124:
1117:
1113:
1108:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
773:
771:
768:
767:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
695:mitochondrion
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
596:
594:
591:
590:
587:
586:Gene ontology
583:
579:
567:
562:
558:
553:
550:
548:
544:
536:
531:
520:
516:
512:
508:
504:
500:
496:
493:adrenal gland
492:
488:
484:
483:
480:
476:
471:
468:
458:
454:
450:
446:
442:
438:
434:
430:
427:Pars compacta
426:
422:
421:
418:
414:
409:
406:
405:
402:
400:
396:
394:
393:
389:
388:
385:
383:
379:
375:
371:
367:
359:
354:
350:
346:
341:
331:
327:
320:
313:
307:
300:
292:
288:
284:
279:
275:
270:
266:
258:
253:
249:
245:
240:
230:
226:
219:
212:
206:
199:
195:
189:
185:
181:
176:
172:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
115:
110:
103:
98:
93:
82:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
7768:
7767:
7748:
7734:
7678:
7664:
7642:Tritoqualine
7613:
7596:
7553:
7523:
7487:
7473:
7421:Quinalizarin
7406:Neluxicapone
7387:
7327:Metanephrine
7292:
7256:
7242:
7205:Fusaric acid
7186:
7172:
7140:Bulbocapnine
7116:
7099:
7086:
7073:
7059:
7003:Tisolagiline
6998:Sembragiline
6989:Selegiline (
6917:
6914:
6892:Sercloremine
6872:Metralindole
6792:
6789:
6767:Procarbazine
6762:Pivhydrazine
6752:Pheniprazine
6677:Furazolidone
6658:
6655:
6592:Metanephrine
6561:
6511:
6443:
6423:Non-specific
6362:Translocases
6359:
6346:
6333:
6320:
6307:
6297:Transferases
6294:
6281:
6138:Binding site
5967:
5886:flavoprotein
5690:, including
5688:dioxygenases
5619:
5599:
5478:
5458:
5404:
5374:
5365:
5319:
5299:
5267:involved in
5222:
5218:Lipoxygenase
5103:
5088:
4994:
4990:
4960:(1): 123–5.
4957:
4953:
4920:
4916:
4875:
4871:
4844:
4840:
4811:
4807:
4782:
4778:
4750:
4746:
4709:
4705:
4679:
4676:Biochemistry
4675:
4642:(16): 6733.
4639:
4635:
4609:(3): 971–5.
4606:
4602:
4560:
4556:
4531:
4527:
4500:
4496:
4447:
4443:
4394:
4390:
4353:
4349:
4315:
4281:(5): 350–3.
4278:
4274:
4264:
4239:
4235:
4229:
4204:
4200:
4193:
4163:(3): 760–4.
4160:
4156:
4149:
4124:
4120:
4114:
4081:
4077:
4070:
4056:
4019:
4014:
4004:
3971:
3965:
3959:
3926:
3922:
3877:
3873:
3863:
3838:
3835:Biochemistry
3834:
3828:
3801:
3797:
3787:
3750:
3746:
3690:
3686:
3645:
3641:
3635:
3590:
3586:
3576:
3531:
3527:
3517:
3490:
3486:
3476:
3441:
3437:
3395:
3391:
3381:
3348:
3344:
3338:
3311:
3307:
3297:
3252:
3248:
3238:
3213:
3210:Biochemistry
3209:
3203:
3178:
3175:Biochemistry
3174:
3167:
3134:
3130:
3096:
3093:Biochemistry
3092:
3085:
3052:
3048:
3014:
3010:
3003:
2968:
2964:
2954:
2919:
2915:
2905:
2872:
2868:
2859:
2832:
2828:
2818:
2801:
2797:
2791:
2766:
2762:
2724:
2720:
2680:
2676:
2666:
2631:
2621:
2596:
2592:
2550:
2546:
2510:
2506:
2460:
2454:
2445:
2436:
2427:
2418:
2355:hypertension
2333:
2296:pathogenetic
2270:
2239:
2193:
2153:
2142:
2138:
2134:
2094:
2091:biosynthesis
2009:homotetramer
1998:
1995:
1928:
1897:
1854:
1818:hydroxylated
1807:
1669:BRENDA entry
1546:
1476:
1472:
1471:
1394:
1357:
1331:
1302:
1278:
1255:
1229:
1210:
1184:
1165:
1145:
1140:
1001:pigmentation
439:hypothalamus
397:
390:
356:142,484,865
343:142,446,489
117:External IDs
72:
7776:Adrenergics
7749:Inhibitors:
7682:Amodiaquine
7679:Inhibitors:
7614:Inhibitors:
7488:Inhibitors:
7440:Tryptamines
7388:Inhibitors:
7323:Epinephrine
7257:Inhibitors:
7187:Inhibitors:
7135:Aquayamycin
7117:Inhibitors:
7074:Inhibitors:
7031:epinephrine
6921:Adarigiline
6915:Inhibitors:
6882:Moclobemide
6811:Brofaromine
6806:Befloxatone
6801:Bazinaprine
6790:Inhibitors:
6697:Iproclozide
6687:Hydralazine
6656:Inhibitors:
6578:Tooltip ALR
6515:Benserazide
6512:Inhibitors:
6133:Active site
5620:catabolism:
5479:catabolism:
5405:catabolism:
5356:epinephrine
5320:catabolism:
5203:Hemerythrin
5187:Transferrin
5182:Lactoferrin
5071:PDB gallery
2971:(1): 1–12.
2835:(1): 21–6.
2363:aquayamycin
2324:effects of
2231:hypotension
2203:epinephrine
2201:as well as
2038:active site
2021:alpha helix
1657:IntEnz view
1617:Identifiers
1604:using Fe, O
1538:epinephrine
1376:NP_954987.2
1372:NP_954986.2
95:Identifiers
7848:EC 1.14.16
7837:Categories
7702:Quinacrine
7637:Naringenin
7632:Meciadanol
7603:-Histidine
7477:Tryptophan
7411:Nitecapone
7401:Entacapone
7260:CGS-19281A
7210:Nepicastat
7195:Disulfiram
7190:Bupicomide
7145:Metirosine
6993:-Deprenyl)
6984:Safinamide
6979:Rasagiline
6964:Mofegiline
6959:Milacemide
6954:Lazabemide
6949:Ladostigil
6926:Almoxatone
6902:Toloxatone
6897:Tetrindole
6887:Pirlindole
6831:Eprobemide
6821:Clorgiline
6816:Cimoxatone
6796:Amiflamine
6747:Phenelzine
6742:Paraxazone
6722:Mebanazine
6702:Iproniazid
6692:Indantadol
6682:Guineesine
6667:Caroxazone
6535:Methyldopa
6505:Tryptamine
6501:Tryptophan
6471:-Histidine
6416:modulators
6413:metabolism
6336:Isomerases
6310:Hydrolases
6177:Regulation
6018:Tyrosinase
5985:: reduced
5948:: reduced
5916:: reduced
5880:: reduced
5600:anabolism:
5502:tryptophan
5459:anabolism:
5366:anabolism:
5300:anabolism:
4923:(6): 716.
3708:1808/17671
2769:: 355–81.
2727:: 2910–7.
2413:, May 2017
2392:, May 2017
2369:References
2336:metirosine
2309:and other
2079:Regulation
2070:homologous
1883:back to BH
1869:dehydrated
1726:structures
1693:KEGG entry
1640:9036-22-0
1485:amino acid
730:perikaryon
401:(ortholog)
255:2,171,815
242:2,163,929
138:HomoloGene
7769:See also:
7738:Histamine
7707:SKF-91488
7697:Metoprine
7692:Harmaline
7668:Histamine
7607:Histamine
7575:Histamine
7561:Melatonin
7527:Serotonin
7450:melatonin
7446:serotonin
7426:Tolcapone
7416:Opicapone
7265:SKF-64139
7220:Tropolone
6974:Pargyline
6934:-Deprenyl
6877:Minaprine
6857:norharman
6849:harmaline
6772:Safrazine
6737:Octamoxin
6732:Nialamide
6717:Linezolid
6712:Isoniazid
6645:Serotonin
6530:Genistein
6520:Carbidopa
6492:-Tyrosine
6475:Histamine
6463:Serotonin
6410:Monoamine
6215:EC number
5987:ascorbate
5950:pteridine
5523:Aromatic
5510:melatonin
5506:serotonin
5445:glutamate
5380:Aromatic
5290:histamine
5286:histidine
5277:monoamine
2513:: 15–35.
2322:cytotoxic
2030:glutamate
2026:histidine
2015:. At the
1975:substrate
1961:Structure
1834:oxygenase
1810:catalyzes
1646:Databases
1628:1.14.16.2
1571:(AAAHs).
1522:cofactors
1516:(Fe) and
1491:-tyrosine
1397:NP_033403
1368:NP_954987
1364:NP_954986
1360:NP_000351
1334:NM_009377
1313:NM_199293
1309:NM_199292
1305:NM_000360
1131:Orthologs
936:cognition
685:cytoplasm
146:GeneCards
7617:Catechin
7491:AGN-2979
7296:Dopamine
7270:SKF-7698
7200:Dopastin
7176:Dopamine
7150:Oudenone
7103:Tyrosine
7067:Tyrosine
7027:dopamine
6969:Nicotine
6836:Esuprone
6662:Benmoxin
6627:Dopamine
6496:Tyramine
6454:Dopamine
6239:Kinetics
6163:Cofactor
6126:Activity
5551:arginine
5352:dopamine
5348:tyrosine
5170:Ferritin
4982:26870241
4734:44602622
4370:12428766
4340:19361815
4221:10623641
4185:37490585
4141:21920445
4106:46062969
4048:34834538
3996:10689202
3988:17690069
3951:20406829
3943:17064352
3896:16488877
3779:19801645
3717:14631117
3662:15639226
3468:24324381
3460:15569247
3414:16644734
3373:14759673
3159:20007900
3113:18181650
3069:19396395
2995:21176768
2897:46042840
2865:Vrana KE
2783:10872454
2743:14216443
2658:10727395
2613:17305546
2575:35753000
2409:–
2388:–
2359:oudenone
2288:dopamine
2237:(iNTD).
2219:levodopa
2215:dystonia
2199:dopamine
2180:nicotine
2170:such as
2156:Hormones
2117:MAPKAPK2
2005:subunits
2001:tetramer
1797:proteins
1785:articles
1773:articles
1730:RCSB PDB
1595:tyrosine
1575:Reaction
1530:dopamine
1445:Wikidata
1110:Sources:
811:learning
750:dendrite
431:testicle
7827:Biology
7712:Tacrine
6944:Ethanol
6845:harmine
6843:(e.g.,
6349:Ligases
6119:Enzymes
6033:1.14.99
6011:: other
6005:1.14.18
5983:1.14.17
5946:1.14.16
5914:1.14.15
5878:1.14.14
5778:1.14.13
5705:1.14.11
5586:choline
5265:Enzymes
5196:nonheme
5011:8528210
4974:7814018
4945:1057532
4937:7789962
4908:4259663
4900:7715703
4880:Bibcode
4863:6150037
4828:2905129
4799:2902075
4769:2896667
4726:2892893
4696:2892528
4666:2888085
4623:2887169
4593:4314044
4585:2882428
4565:Bibcode
4548:2872999
4519:1973163
4484:1347949
4452:Bibcode
4399:Bibcode
4378:8814324
4332:6137760
4297:5726288
4256:5545929
4177:2879891
4098:9075305
4039:8625014
3904:5939578
3855:9636040
3820:1352289
3770:2781693
3725:5950778
3627:2902623
3595:Bibcode
3568:1347949
3536:Bibcode
3509:7901013
3365:2878973
3330:1973163
3289:3475690
3257:Bibcode
3230:2412578
3195:9753429
3151:9228951
3031:2902075
2986:3065393
2946:8535244
2937:2142982
2889:7964718
2851:2889594
2699:8798695
2649:1220924
2567:9626667
2519:8822146
2487:8638482
2411:Ensembl
2390:Ensembl
2164:cocaine
2013:domains
1971:domains
1916:cytosol
1820:in the
1752:QuickGO
1717:profile
1700:MetaCyc
1635:CAS no.
1479:is the
1243:UniProt
1198:Ensembl
1137:Species
1116:QuickGO
1071:hearing
710:nucleus
690:cytosol
376:pattern
234:11p15.5
102:Aliases
7813:Portal
6853:harman
6649:5-HIAA
6323:Lyases
5882:flavin
5761:ALKBH1
5037:(MeSH)
5009:
4980:
4972:
4943:
4935:
4906:
4898:
4872:Nature
4861:
4826:
4797:
4767:
4732:
4724:
4694:
4664:
4657:306135
4654:
4621:
4591:
4583:
4557:Nature
4546:
4517:
4482:
4472:
4429:
4422:336196
4419:
4376:
4368:
4338:
4330:
4295:
4254:
4219:
4183:
4175:
4139:
4104:
4096:
4046:
4036:
3994:
3986:
3949:
3941:
3902:
3894:
3853:
3818:
3777:
3767:
3723:
3715:
3660:
3625:
3618:282128
3615:
3566:
3556:
3507:
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3458:
3412:
3371:
3363:
3328:
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3280:298896
3277:
3228:
3193:
3157:
3149:
3111:
3077:930361
3075:
3067:
3029:
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2517:
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2475:
2266:type I
2264:(APS)
2227:miosis
2223:ptosis
2166:), or
2158:(e.g.
2101:serine
1931:indole
1780:PubMed
1762:Search
1748:AmiGO
1736:PDBsum
1676:ExPASy
1664:BRENDA
1652:IntEnz
1623:EC no.
1608:and BH
1481:enzyme
1431:search
1429:PubMed
1280:P24529
1261:P78428
1257:P07101
1153:Entrez
886:memory
547:BioGPS
501:zygote
126:191290
7512:AANAT
7481:5-HTP
7336:MOPEG
7332:DOPEG
7305:DOPAC
6631:DOPAC
6459:5-HTP
6275:Types
6051:HMOX1
5786:NADPH
5744:P4HTM
5737:EGLN3
5732:EGLN2
5727:EGLN1
5698:1.14)
4978:S2CID
4941:S2CID
4904:S2CID
4730:S2CID
4589:S2CID
4475:48658
4431:33381
4374:S2CID
4336:S2CID
4181:S2CID
4102:S2CID
3992:S2CID
3947:S2CID
3900:S2CID
3721:S2CID
3683:(PDF)
3559:48658
3464:S2CID
3369:S2CID
3155:S2CID
3073:S2CID
2893:S2CID
2571:S2CID
2343:-DOPA
2329:-DOPA
2318:-DOPA
2284:-DOPA
1712:PRIAM
1602:-DOPA
1186:21823
1146:Mouse
1141:Human
1112:Amigo
451:gonad
399:Mouse
392:Human
339:Start
274:Mouse
238:Start
171:Human
134:98735
7653:HNMT
7542:ASMT
7341:DOMA
7281:COMT
7231:PNMT
6618:MHPG
6609:DHMA
6596:MHPG
6587:DHMA
6565:ALDH
6525:DFMD
6432:AAAD
6367:list
6360:EC7
6354:list
6347:EC6
6341:list
6334:EC5
6328:list
6321:EC4
6315:list
6308:EC3
6302:list
6295:EC2
6289:list
6282:EC1
6067:21A2
6062:17A1
5936:11A1
5931:11B2
5926:11B1
5894:19A1
5841:NOS3
5836:NOS2
5831:NOS1
5819:FMO5
5814:FMO4
5809:FMO3
5804:FMO2
5799:FMO1
5782:NADH
5756:AlkB
5575:NOS3
5571:NOS2
5567:NOS1
5449:GABA
5163:heme
5104:2toh
5089:1toh
5007:PMID
4970:PMID
4933:PMID
4896:PMID
4859:PMID
4824:PMID
4795:PMID
4765:PMID
4722:PMID
4692:PMID
4662:PMID
4619:PMID
4581:PMID
4544:PMID
4515:PMID
4480:PMID
4427:PMID
4366:PMID
4328:PMID
4293:PMID
4252:PMID
4217:PMID
4173:PMID
4137:PMID
4094:PMID
4044:PMID
3984:PMID
3939:PMID
3892:PMID
3851:PMID
3816:PMID
3775:PMID
3713:PMID
3658:PMID
3623:PMID
3564:PMID
3505:PMID
3456:PMID
3410:PMID
3361:PMID
3326:PMID
3285:PMID
3226:PMID
3191:PMID
3147:PMID
3109:PMID
3065:PMID
3027:PMID
2991:PMID
2942:PMID
2885:PMID
2847:PMID
2779:PMID
2739:PMID
2695:PMID
2654:PMID
2609:PMID
2563:PMID
2515:PMID
2483:PMID
2473:ISBN
2361:and
2248:and
2205:and
2172:cAMP
2064:and
1889:iron
1822:meta
1792:NCBI
1733:PDBe
1688:KEGG
1563:and
1549:gene
1514:iron
1167:7054
735:axon
382:Bgee
330:Band
291:Chr.
229:Band
188:Chr.
122:OMIM
79:4J6S
75:2XSN
56:RCSB
53:PDBe
7723:DAO
7585:HDC
7462:TPH
7345:VMA
7161:DBH
7048:PAH
6640:HVA
6622:VMA
6600:VMA
6574:ALR
6546:MAO
5904:2E1
5899:2D6
5884:or
5858:3A4
5784:or
5766:FTO
4999:doi
4962:doi
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4888:doi
4876:374
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4845:259
4816:doi
4812:157
4787:doi
4783:103
4755:doi
4751:263
4714:doi
4684:doi
4652:PMC
4644:doi
4611:doi
4607:146
4573:doi
4561:326
4536:doi
4505:doi
4501:265
4470:PMC
4460:doi
4417:PMC
4407:doi
4358:doi
4320:doi
4283:doi
4244:doi
4209:doi
4205:267
4165:doi
4129:doi
4086:doi
4034:PMC
4024:doi
3976:doi
3931:doi
3927:100
3882:doi
3843:doi
3806:doi
3802:267
3765:PMC
3755:doi
3751:284
3703:hdl
3695:doi
3650:doi
3646:434
3613:PMC
3603:doi
3554:PMC
3544:doi
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1850:4
1842:L
1838:2
1830:L
1826:L
1814:L
1610:4
1606:2
1600:L
1526:L
1510:2
1502:L
1500:(
1496:L
1489:L
276:)
173:)
156::
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