338:
315:
212:
237:
589:
344:
243:
5436:
3244:"Constitutive and interleukin-1-inducible phosphorylation of p65 NF-κB at serine 536 is mediated by multiple protein kinases including IκB kinase IKK-α, IKK-β, IKK-ε, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription"
29:
55:
3051:"Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling"
3299:
3584:
1480:
pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFkB activation in response to certain
3127:
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".
2376:
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".
3209:"NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach"
3292:
3166:"Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity"
1754:"Recent insights into the complexity of Tank-binding kinase 1 signaling networks: the emerging role of cellular localization in the activation and substrate specificity of TBK1"
3285:
2932:
Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, et al. (May 2003). "IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway".
3492:
1424:
351:
250:
2547:"Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1"
2761:
Zandi E, Chen Y, Karin M (August 1998). "Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate".
1645:
4040:
4879:
3343:
2903:
Li SF, Fujita F, Hirai M, Lu R, Niida H, Nakanishi M (January 2003). "Genomic structure and characterization of the promoter region of the human NAK gene".
4988:
3726:
3613:
2969:
Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J (May 2003). "Triggering the interferon antiviral response through an IKK-related pathway".
972:
953:
173:
4001:
4974:
4439:
3330:
3312:
5076:
4957:
1356:
and forms a node between them. For this reason, regulation of its involvement in individual signaling pathways is necessary. This is provided by
2835:"IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2"
4663:
3532:
5456:
4727:
3702:
1725:
1707:
4983:
2870:"Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases"
337:
52:
3517:
1179:
5040:
4715:
1357:
1172:
314:
5155:
3972:
3962:
3647:
1798:
4654:
4923:
4595:
3957:
3948:
1694:
1673:
236:
211:
5311:
2128:"Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria"
1690:
2586:
Llona-Minguez S, Baiget J, Mackay SP (July 2013). "Small-molecule inhibitors of IκB kinase (IKK) and IKK-related kinases".
4338:
3835:
3826:
3483:
3429:
1603:
5426:
1669:
3526:
1427:
153:
1520:
3086:"Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling"
3277:
3016:"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways"
350:
249:
4550:
4368:
3864:
5296:
5412:
5399:
5386:
5373:
5360:
5347:
5334:
4540:
4535:
4530:
4520:
4515:
4510:
4500:
4295:
4070:
3666:
343:
242:
5306:
5260:
5203:
4763:
4754:
4705:
3471:
3316:
1607:
1361:
1017:
161:
2685:"A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain"
2285:"A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain"
1499:
receptors and components of the autophagy apparatus. Furthermore, TBK1 is also involved in the regulation of
2792:"Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription"
2421:"Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription"
5208:
5063:
4486:
1624:(IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of
998:
2720:"Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity"
2234:
Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, et al. (January 2020).
1476:. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the
2326:"NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase"
5229:
5148:
1310:
225:
5301:
2236:"TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease"
4329:
2978:
2634:
2498:"Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes"
2139:
1633:
1591:
1400:
1255:
140:
1468:
In the canonical NFkB pathway, the NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (
5265:
1426:, but TBK1 seems to play a more important role. After triggering antiviral signaling through PRRs (
1333:
4837:
5461:
5198:
4940:
4894:
3152:
3002:
2957:
2749:
2401:
2079:"TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation"
2059:
1500:
1353:
1259:
185:
1155:
1134:
1108:
1087:
2077:
Pilli M, Arko-Mensah J, Ponpuak M, Roberts E, Master S, Mandell MA, et al. (August 2012).
1409:
4200:
3909:
3265:
3230:
3195:
3144:
3115:
3072:
3037:
2994:
2949:
2920:
2891:
2856:
2821:
2778:
2741:
2706:
2660:
2603:
2568:
2527:
2450:
2393:
2355:
2306:
2265:
2216:
2167:
2108:
2051:
2010:
1956:
1902:
1850:
1775:
1599:
1458:
1299:
1279:
133:
45:
1377:
5244:
5239:
5213:
5141:
4793:
4035:
4025:
4020:
3938:
3929:
3859:
3850:
3796:
3787:
3444:
3255:
3220:
3185:
3177:
3136:
3105:
3097:
3062:
3027:
2986:
2941:
2912:
2881:
2846:
2811:
2803:
2770:
2731:
2696:
2650:
2642:
2595:
2558:
2517:
2509:
2496:
Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, et al. (July 2007).
2440:
2432:
2385:
2345:
2337:
2296:
2255:
2247:
2206:
2198:
2157:
2147:
2098:
2090:
2041:
2000:
1990:
1946:
1936:
1892:
1884:
1840:
1830:
1765:
1546:
1365:
430:
361:
305:
260:
1360:
that interact with the dimerization domain of TBK1 to determine its location and access to
5291:
5275:
5188:
4619:
3690:
3685:
3680:
3164:
tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, et al. (October 2004).
3014:
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, et al. (May 2003).
1462:
1389:
1295:
588:
405:
181:
144:, Tbk1, 1200008B05Rik, AI462036, AW048562, NAK, T2K, FTDALS4, TANK binding kinase 1, IIAE8
3084:
Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, et al. (November 2003).
2982:
2833:
Kishore N, Huynh QK, Mathialagan S, Hall T, Rouw S, Creely D, et al. (April 2002).
2655:
2638:
2622:
2143:
1368:
and phosphorylation of substrates which is required for subsequent production of type I
5440:
5329:
5270:
3181:
3049:
Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S (October 2003).
2790:
Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, et al. (September 2000).
2522:
2497:
2419:
Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, et al. (September 2000).
2350:
2325:
2260:
2235:
2211:
2186:
2162:
2127:
2103:
2078:
2005:
1978:
1951:
1924:
1897:
1872:
1845:
1818:
1583:
1477:
1283:
3190:
3165:
3110:
3085:
2916:
2816:
2791:
2736:
2719:
2445:
2420:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
716:
711:
706:
701:
696:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
5450:
5234:
5193:
3743:
3675:
3101:
1617:
1579:
1492:
1481:
1404:
1326:
617:
3156:
3006:
2961:
2405:
2126:
Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, et al. (April 2016).
165:
5183:
4614:
3439:
3207:
Kuai J, Wooters J, Hall JP, Rao VR, Nickbarg E, Li B, et al. (December 2004).
2063:
1625:
1435:
1393:
1275:
423:
202:
2774:
2753:
1770:
1753:
2202:
2094:
189:
5407:
5342:
5178:
4820:
4452:
4392:
4275:
4195:
3919:
3067:
3050:
2868:
Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U (October 2002).
1730:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1712:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1534:
1322:
5435:
2807:
2646:
2563:
2546:
2436:
2341:
2185:
Kumar S, Gu Y, Abudu YP, Bruun JA, Jain A, Farzam F, et al. (April 2019).
2132:
Proceedings of the
National Academy of Sciences of the United States of America
1430:), TBK1 is activated. Subsequently, it phosphorylates the transcription factor
506:
4908:
3382:
2030:"NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria"
1941:
1888:
1587:
1578:
in this protein are associated with many diseases. Due to the role of TBK1 in
1450:
1369:
1318:
1306:
322:
219:
169:
3242:
Buss H, Dörrie A, Schmitz ML, Hoffmann E, Resch K, Kracht M (December 2004).
2513:
1835:
5381:
5355:
3869:
2990:
2701:
2684:
2301:
2284:
2251:
2152:
1504:
1496:
1488:
1473:
1385:
1381:
1314:
1267:
1263:
1247:
917:
566:
444:
389:
376:
288:
275:
177:
3269:
3260:
3243:
3234:
3225:
3208:
3199:
3148:
3119:
3076:
3041:
3032:
3015:
2998:
2953:
2924:
2895:
2886:
2869:
2860:
2851:
2834:
2825:
2664:
2607:
2572:
2531:
2454:
2397:
2359:
2269:
2220:
2171:
2112:
2055:
2046:
2029:
2028:
von
Muhlinen N, Thurston T, Ryzhakov G, Bloor S, Randow F (February 2010).
2014:
1960:
1906:
1854:
1779:
2782:
2745:
2710:
2545:
Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, et al. (April 2014).
2310:
1219:
1214:
4225:
4120:
4115:
4110:
2468:
1995:
1575:
1469:
1203:
1062:
1043:
4884:
4862:
4857:
4847:
4842:
4644:
4639:
4634:
4629:
4624:
4609:
4604:
4255:
4220:
3459:
3454:
3449:
1873:"Assessment of TANK-binding kinase 1 as a therapeutic target in cancer"
1508:
1029:
984:
2599:
2551:
Laboratory
Investigation; A Journal of Technical Methods and Pathology
2187:"Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation"
1819:"TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity"
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
5394:
5164:
5114:
5109:
5104:
5099:
5094:
5089:
5084:
5035:
5030:
5025:
5020:
5015:
4998:
4993:
4867:
4852:
4803:
4798:
4783:
4778:
4773:
4768:
4742:
4737:
4732:
4720:
4698:
4693:
4585:
4560:
4235:
4060:
4055:
4050:
4045:
4030:
3874:
3811:
3806:
3801:
3777:
3603:
3598:
3572:
3567:
3562:
3552:
3547:
3537:
3377:
3308:
1629:
1341:
1337:
1243:
1239:
1235:
1187:
939:
3140:
2389:
1925:"TBK1: a new player in ALS linking autophagy and neuroinflammation"
1441:
As a non-canonical IKK, TBK1 is also involved in the non-canonical
888:
positive regulation of type I interferon-mediated signaling pathway
5368:
5010:
5003:
4913:
4810:
4710:
4688:
4683:
4678:
4673:
4668:
4580:
4575:
4570:
4565:
4555:
4525:
4505:
4382:
4377:
4358:
4353:
4343:
4319:
4314:
4309:
4285:
4280:
4270:
4265:
4260:
4250:
4230:
4215:
4210:
4205:
4185:
4180:
4170:
4165:
4160:
4155:
4150:
4140:
4135:
4130:
4125:
4105:
4100:
4095:
4090:
4085:
4080:
4065:
4015:
4010:
3904:
3899:
3894:
3889:
3884:
3879:
3840:
3772:
3767:
3716:
3711:
3637:
3632:
3627:
3593:
3585:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3387:
3372:
3367:
3362:
3357:
3352:
2945:
1621:
1595:
1540:
1454:
1446:
1388:. Another adaptor protein that determines the location of TBK1 is
1271:
902:
898:
4903:
4830:
4825:
4815:
4788:
4545:
4495:
4476:
4471:
4466:
4461:
4416:
4411:
4406:
4401:
4348:
4304:
4245:
4240:
4190:
4175:
4145:
4075:
3991:
3986:
3981:
3914:
3816:
3757:
3752:
3656:
3622:
3507:
3502:
3497:
3466:
3434:
3422:
3417:
3412:
3402:
3397:
1563:
1559:
1555:
1528:
1442:
1431:
1373:
1251:
597:
157:
28:
5137:
5061:
4437:
3328:
3281:
2623:"Targeting TBK1 to overcome resistance to cancer immunotherapy"
4872:
3407:
3392:
1554:
Transcription factors activated upon TBK1 activation include
1340:
172, which requires homodimerization and ubiquitinylation of
1403:, especially in antiviral responses. TBK1 is redundant with
1274:
immunity. Insufficient regulation of TBK1 activity leads to
1979:"Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer"
5133:
798:
positive regulation of I-kappaB kinase/NF-kappaB signaling
833:
positive regulation of transcription by RNA polymerase II
1472:) proteins, which inactivate NFKB by trapping it in the
413:
1325:
structures (region 407-713) that provide a surface for
1254:
in humans. This kinase is mainly known for its role in
763:
positive regulation of peptidyl-serine phosphorylation
5424:
1412:
578:
1613:
The loss of TBK1 cause embryonic lethality in mice.
5320:
5284:
5253:
5222:
5171:
5075:
4973:
4956:
4939:
4922:
4893:
4753:
4653:
4594:
4485:
4451:
4391:
4367:
4328:
4294:
4000:
3971:
3947:
3928:
3849:
3825:
3786:
3742:
3725:
3701:
3665:
3646:
3612:
3583:
3516:
3482:
3342:
1148:
1127:
1101:
1080:
828:
positive regulation of type I interferon production
803:
negative regulation of type I interferon production
768:
TRIF-dependent toll-like receptor signaling pathway
2491:
2489:
1686:
1684:
1682:
1665:
1663:
1661:
1582:, deregulation of its activity is associated with
1418:
738:positive regulation of interferon-alpha production
1977:Durand JK, Zhang Q, Baldwin AS (September 2018).
1923:Oakes JA, Davies MC, Collins MO (February 2017).
1258:antiviral response. However, TBK1 also regulates
848:positive regulation of interferon-beta production
360:
259:
2371:
2369:
1364:. Binding to TANK leads to localization to the
16:Protein-coding gene in the species Homo sapiens
1752:Helgason E, Phung QT, Dueber EC (April 2013).
1691:GRCm38: Ensembl release 89: ENSMUSG00000020115
1344:30 and 401, is necessary for kinase activity.
5149:
3344:Non-specific serine/threonine protein kinases
3293:
1399:A key interest in TBK1 is due to its role in
8:
2718:Chen ZJ, Parent L, Maniatis T (March 1996).
2324:Pomerantz JL, Baltimore D (December 1999).
1877:Journal of Cell Communication and Signaling
1670:GRCh38: Ensembl release 89: ENSG00000183735
843:defense response to Gram-positive bacterium
5156:
5142:
5134:
5072:
5058:
4448:
4434:
3727:Goodpasture-antigen-binding protein kinase
3339:
3325:
3300:
3286:
3278:
2621:Sun, Y.; Anderson, S. (January 12, 2023).
1250:protein kinase. It is encoded by the TBK1
913:
853:regulation of type I interferon production
613:
401:
300:
197:
63:
4440:Serine/threonine-specific protein kinases
3614:(isocitrate dehydrogenase (NADP+)) kinase
3331:Serine/threonine-specific protein kinases
3313:Serine/threonine-specific protein kinases
3259:
3224:
3189:
3109:
3066:
3031:
2885:
2850:
2815:
2735:
2700:
2654:
2562:
2521:
2469:"TANK-binding kinase 1-binding protein 1"
2444:
2349:
2300:
2259:
2210:
2161:
2151:
2102:
2045:
2004:
1994:
1950:
1940:
1896:
1844:
1834:
1799:"Entrez Gene: TBK1 TANK-binding kinase 1"
1769:
1449:, which is subsequently processed in the
1411:
4975:Receptor protein serine/threonine kinase
1817:Louis C, Burns C, Wicks I (2018-03-06).
1793:
1791:
1789:
1646:CGAS–STING cytosolic DNA sensing pathway
1519:TANK-binding kinase 1 has been shown to
1298:the nuclear factor kB (NFkB). It shares
1294:TBK1 is a non-canonical IKK kinase that
883:regulation of cellular metabolic process
646:protein serine/threonine kinase activity
5431:
4958:Low-density-lipoprotein receptor kinase
1657:
1632:, and a way to overcome resistance to
873:cellular response to cytokine stimulus
758:negative regulation of gene expression
18:
3703:Fas-activated serine/threonine kinase
1972:
1970:
858:positive regulation of macroautophagy
365:
326:
321:
264:
223:
218:
7:
4984:Bone morphogenetic protein receptors
1918:
1916:
1866:
1864:
1812:
1810:
1808:
1747:
1745:
1743:
1741:
1739:
1438:, and promotes production of IFN-I.
1290:Structure and regulation of activity
793:activation of innate immune response
553:vestibular membrane of cochlear duct
3518:Dephospho-(reductase kinase) kinase
3248:The Journal of Biological Chemistry
3213:The Journal of Biological Chemistry
2874:The Journal of Biological Chemistry
2839:The Journal of Biological Chemistry
2689:The Journal of Biological Chemistry
2289:The Journal of Biological Chemistry
1317:-like domain (region 310-385). The
823:I-kappaB kinase/NF-kappaB signaling
3973:G-protein coupled receptor kinases
3182:10.1128/JVI.78.19.10636-10649.2004
2683:Chou MM, Hanafusa H (March 1995).
2283:Chou MM, Hanafusa H (March 1995).
1871:Cruz VH, Brekken RA (March 2018).
1574:Deregulation of TBK1 activity and
1145:
1124:
1098:
1077:
1053:
1034:
1008:
989:
963:
944:
863:peptidyl-threonine phosphorylation
583:
501:
439:
418:
14:
3963:Beta adrenergic receptor kinase-2
3648:(tyrosine 3-monooxygenase) kinase
1372:(IFN-I). In contrast, binding to
1348:Involvement in signaling pathways
463:lateral nuclear group of thalamus
5434:
4655:Mitogen-activated protein kinase
3102:10.1128/MCB.23.21.7780-7793.2003
1620:(IKK) and IKK-related kinases,
1242:activity. Specifically, it is a
753:positive regulation of xenophagy
587:
349:
342:
336:
313:
248:
241:
235:
210:
27:
5041:Anti-Müllerian hormone receptor
4924:(acetyl-CoA carboxylase) kinase
4596:(RNA-polymerase)-subunit kinase
3958:Beta adrenergic receptor kinase
3949:Beta adrenergic receptor kinase
1495:clearance. TBK1 phosphorylates
1434:, which is translocated to the
783:peptidyl-serine phosphorylation
4664:Extracellular signal-regulated
3090:Molecular and Cellular Biology
598:More reference expression data
567:More reference expression data
1:
4728:P38 mitogen-activated protein
3827:cGMP-dependent protein kinase
3788:cAMP-dependent protein kinase
3484:Pyruvate dehydrogenase kinase
3430:Ataxia telangiectasia mutated
2917:10.1016/S0378-1119(02)01179-4
2775:10.1126/science.281.5381.1360
2737:10.1016/S0092-8674(00)81064-8
2588:Pharmaceutical Patent Analyst
1771:10.1016/j.febslet.2013.01.059
1604:amyotrophic lateral sclerosis
1428:pattern recognition receptors
1380:leads to localization in the
878:regulation of gene expression
334:
233:
5457:Genes on human chromosome 12
3527:AMP-activated protein kinase
2203:10.1016/j.devcel.2019.01.027
2095:10.1016/j.immuni.2012.04.015
1309:of the protein contains the
1232:TBK1 (TANK-binding kinase 1)
838:dendritic cell proliferation
773:type I interferon production
529:Epithelium of choroid plexus
4442:(EC 2.7.11.21-EC 2.7.11.30)
3068:10.4049/jimmunol.171.8.4304
1445:pathway. It phosphorylates
681:protein phosphatase binding
5478:
4369:Elongation factor 2 kinase
3333:(EC 2.7.11.1-EC 2.7.11.20)
2647:10.1038/s41586-023-05704-6
2564:10.1038/labinvest.2013.153
1180:Chr 10: 121.38 – 121.42 Mb
788:regulation of neuron death
5312:Michaelis–Menten kinetics
5071:
5057:
4764:MAP kinase kinase kinases
4447:
4433:
4296:Myosin light-chain kinase
4002:Ca2+/calmodulin-dependent
3667:Myosin-heavy-chain kinase
3338:
3324:
1942:10.1186/s13041-017-0287-x
1889:10.1007/s12079-017-0438-y
1726:"Mouse PubMed Reference:"
1708:"Human PubMed Reference:"
1491:involved in pathogen and
1419:{\displaystyle \epsilon }
1352:TBK1 is involved in many
1218:
1213:
1209:
1202:
1186:
1167:
1152:
1131:
1120:
1105:
1084:
1073:
1060:
1056:
1041:
1037:
1028:
1015:
1011:
996:
992:
983:
970:
966:
951:
947:
938:
923:
916:
912:
896:
778:defense response to virus
676:identical protein binding
616:
612:
595:
586:
577:
564:
513:
504:
451:
442:
412:
404:
400:
383:
370:
333:
312:
303:
299:
282:
269:
232:
209:
200:
196:
151:
148:
138:
131:
126:
71:
66:
49:
44:
39:
35:
26:
21:
5204:Diffusion-limited enzyme
5064:Dual-specificity kinases
2808:10.1093/emboj/19.18.4976
2514:10.1038/sj.emboj.7601773
2437:10.1093/emboj/19.18.4976
2342:10.1093/emboj/18.23.6694
1836:10.3389/fimmu.2018.00434
1608:herpesviral encephalitis
1606:), and infantile (e.g.,
4487:Cyclin-dependent kinase
2991:10.1126/science.1081315
2702:10.1074/jbc.270.13.7359
2302:10.1074/jbc.270.13.7359
2252:10.15252/embr.201948317
2153:10.1073/pnas.1523926113
1823:Frontiers in Immunology
1461:with RelB and mediates
1392:. TAPE targets TBK1 to
1313:(region 9-309) and the
1173:Chr 12: 64.45 – 64.5 Mb
868:protein phosphorylation
671:protein kinase activity
3261:10.1074/jbc.M409825200
3226:10.1074/jbc.M411037200
3033:10.1038/sj.onc.1206406
2887:10.1074/jbc.M205069200
2852:10.1074/jbc.M110474200
2047:10.4161/auto.6.2.11118
1586:. There are also many
1457:subunit. This subunit
1420:
808:innate immune response
651:phosphoprotein binding
5297:Eadie–Hofstee diagram
5230:Allosteric regulation
3055:Journal of Immunology
1626:inflammatory diseases
1570:Clinical significance
1421:
818:inflammatory response
743:immune system process
549:stroma of bone marrow
328:Chromosome 10 (mouse)
226:Chromosome 12 (human)
5307:Lineweaver–Burk plot
4330:Phosphorylase kinase
1996:10.3390/cells7090139
1634:cancer immunotherapy
1592:rheumatoid arthritis
1410:
1302:with canonical IKK.
661:nucleic acid binding
631:transferase activity
521:facial motor nucleus
67:List of PDB id codes
40:Available structures
3254:(53): 55633–55643.
3219:(51): 53266–53271.
3176:(19): 10636–10649.
3170:Journal of Virology
3129:Nature Cell Biology
2983:2003Sci...300.1148S
2977:(5622): 1148–1151.
2880:(40): 37029–37036.
2845:(16): 13840–13847.
2769:(5381): 1360–1363.
2639:2023Natur.615..158S
2378:Nature Cell Biology
2144:2016PNAS..113.4039R
1384:and involvement in
1334:autophosphorylation
541:conjunctival fornix
455:epithelium of colon
5266:Enzyme superfamily
5199:Enzyme promiscuity
4941:Tropomyosin kinase
4895:Tau-protein kinase
2191:Developmental Cell
1501:cell proliferation
1453:and released as a
1416:
1366:perinuclear region
1354:signaling pathways
1260:cell proliferation
1018:ENSMUSG00000020115
726:Biological process
690:Cellular component
636:nucleotide binding
624:Molecular function
5422:
5421:
5131:
5130:
5127:
5126:
5123:
5122:
5053:
5052:
5049:
5048:
4429:
4428:
4425:
4424:
3910:Protein kinase N1
3865:Protein kinase Cζ
3096:(21): 7780–7793.
3026:(21): 3307–3318.
2934:Nature Immunology
2802:(18): 4976–4985.
2695:(13): 7359–7364.
2633:(7950): 158–167.
2600:10.4155/ppa.13.31
2508:(14): 3451–3462.
2431:(18): 4976–4985.
2336:(23): 6694–6704.
2295:(13): 7359–7364.
2197:(1): 130–144.e6.
2138:(15): 4039–4044.
1600:neurodegenerative
1321:is formed by two
1300:sequence homology
1280:neurodegenerative
1229:
1228:
1225:
1224:
1198:
1197:
1163:
1162:
1142:
1141:
1116:
1115:
1095:
1094:
1069:
1068:
1050:
1049:
1024:
1023:
1005:
1004:
979:
978:
960:
959:
908:
907:
748:response to virus
707:endosome membrane
608:
607:
604:
603:
573:
572:
560:
559:
498:
497:
491:bone marrow cells
396:
395:
295:
294:
122:
121:
118:
117:
50:Ortholog search:
5469:
5439:
5438:
5430:
5302:Hanes–Woolf plot
5245:Enzyme activator
5240:Enzyme inhibitor
5214:Enzyme catalysis
5158:
5151:
5144:
5135:
5073:
5059:
4706:C-Jun N-terminal
4449:
4435:
3939:Rhodopsin kinase
3930:Rhodopsin kinase
3860:Protein kinase C
3851:Protein kinase C
3836:Protein kinase G
3797:Protein kinase A
3408:Protein kinase B
3340:
3326:
3302:
3295:
3288:
3279:
3273:
3263:
3238:
3228:
3203:
3193:
3160:
3123:
3113:
3080:
3070:
3061:(8): 4304–4310.
3045:
3035:
3010:
2965:
2928:
2899:
2889:
2864:
2854:
2829:
2819:
2796:The EMBO Journal
2786:
2757:
2739:
2714:
2704:
2669:
2668:
2658:
2618:
2612:
2611:
2583:
2577:
2576:
2566:
2542:
2536:
2535:
2525:
2502:The EMBO Journal
2493:
2484:
2483:
2481:
2479:
2465:
2459:
2458:
2448:
2425:The EMBO Journal
2416:
2410:
2409:
2373:
2364:
2363:
2353:
2330:The EMBO Journal
2321:
2315:
2314:
2304:
2280:
2274:
2273:
2263:
2231:
2225:
2224:
2214:
2182:
2176:
2175:
2165:
2155:
2123:
2117:
2116:
2106:
2074:
2068:
2067:
2049:
2025:
2019:
2018:
2008:
1998:
1974:
1965:
1964:
1954:
1944:
1920:
1911:
1910:
1900:
1868:
1859:
1858:
1848:
1838:
1814:
1803:
1802:
1795:
1784:
1783:
1773:
1764:(8): 1230–1237.
1749:
1734:
1733:
1722:
1716:
1715:
1704:
1698:
1688:
1677:
1667:
1425:
1423:
1422:
1417:
1358:adaptor proteins
1327:homodimerization
1211:
1210:
1182:
1175:
1158:
1146:
1137:
1125:
1121:RefSeq (protein)
1111:
1099:
1090:
1078:
1054:
1035:
1009:
990:
964:
945:
914:
614:
600:
591:
584:
569:
537:substantia nigra
509:
507:Top expressed in
502:
483:ventricular zone
467:secondary oocyte
447:
445:Top expressed in
440:
419:
402:
392:
379:
368:
353:
346:
340:
329:
317:
301:
291:
278:
267:
252:
245:
239:
228:
214:
198:
192:
190:TBK1 - orthologs
143:
136:
113:
64:
58:
37:
36:
31:
19:
5477:
5476:
5472:
5471:
5470:
5468:
5467:
5466:
5447:
5446:
5445:
5433:
5425:
5423:
5418:
5330:Oxidoreductases
5316:
5292:Enzyme kinetics
5280:
5276:List of enzymes
5249:
5218:
5189:Catalytic triad
5167:
5162:
5132:
5119:
5067:
5045:
4969:
4952:
4935:
4918:
4889:
4749:
4649:
4620:P70-S6 Kinase 1
4590:
4481:
4443:
4421:
4387:
4363:
4324:
4290:
3996:
3967:
3943:
3924:
3845:
3821:
3782:
3738:
3721:
3697:
3691:Aurora C kinase
3686:Aurora B kinase
3681:Aurora A kinase
3661:
3642:
3608:
3579:
3512:
3478:
3334:
3320:
3306:
3276:
3241:
3206:
3163:
3141:10.1038/ncb1086
3126:
3083:
3048:
3013:
2968:
2931:
2902:
2867:
2832:
2789:
2760:
2717:
2682:
2678:
2676:Further reading
2673:
2672:
2620:
2619:
2615:
2585:
2584:
2580:
2544:
2543:
2539:
2495:
2494:
2487:
2477:
2475:
2467:
2466:
2462:
2418:
2417:
2413:
2390:10.1038/ncb1086
2375:
2374:
2367:
2323:
2322:
2318:
2282:
2281:
2277:
2233:
2232:
2228:
2184:
2183:
2179:
2125:
2124:
2120:
2076:
2075:
2071:
2027:
2026:
2022:
1976:
1975:
1968:
1929:Molecular Brain
1922:
1921:
1914:
1870:
1869:
1862:
1816:
1815:
1806:
1797:
1796:
1787:
1751:
1750:
1737:
1724:
1723:
1719:
1706:
1705:
1701:
1689:
1680:
1668:
1659:
1654:
1642:
1572:
1552:
1517:
1463:gene expression
1408:
1407:
1401:innate immunity
1350:
1292:
1256:innate immunity
1220:View/Edit Mouse
1215:View/Edit Human
1178:
1171:
1168:Location (UCSC)
1154:
1133:
1107:
1086:
999:ENSG00000183735
892:
733:phosphorylation
721:
685:
656:protein binding
641:kinase activity
596:
565:
556:
551:
547:
543:
539:
535:
531:
527:
523:
519:
505:
494:
489:
485:
481:
477:
473:
469:
465:
461:
459:Achilles tendon
457:
443:
387:
374:
366:
356:
355:
354:
347:
327:
304:Gene location (
286:
273:
265:
255:
254:
253:
246:
224:
201:Gene location (
152:
139:
132:
73:
51:
17:
12:
11:
5:
5475:
5473:
5465:
5464:
5459:
5449:
5448:
5444:
5443:
5420:
5419:
5417:
5416:
5403:
5390:
5377:
5364:
5351:
5338:
5324:
5322:
5318:
5317:
5315:
5314:
5309:
5304:
5299:
5294:
5288:
5286:
5282:
5281:
5279:
5278:
5273:
5268:
5263:
5257:
5255:
5254:Classification
5251:
5250:
5248:
5247:
5242:
5237:
5232:
5226:
5224:
5220:
5219:
5217:
5216:
5211:
5206:
5201:
5196:
5191:
5186:
5181:
5175:
5173:
5169:
5168:
5163:
5161:
5160:
5153:
5146:
5138:
5129:
5128:
5125:
5124:
5121:
5120:
5118:
5117:
5112:
5107:
5102:
5097:
5092:
5087:
5081:
5079:
5069:
5068:
5062:
5055:
5054:
5051:
5050:
5047:
5046:
5044:
5043:
5038:
5033:
5028:
5023:
5018:
5013:
5008:
5007:
5006:
5001:
4996:
4991:
4980:
4978:
4977:(EC 2.7.11.30)
4971:
4970:
4968:
4967:
4963:
4961:
4960:(EC 2.7.11.29)
4954:
4953:
4951:
4950:
4946:
4944:
4943:(EC 2.7.11.28)
4937:
4936:
4934:
4933:
4929:
4927:
4926:(EC 2.7.11.27)
4920:
4919:
4917:
4916:
4911:
4906:
4900:
4898:
4897:(EC 2.7.11.26)
4891:
4890:
4888:
4887:
4882:
4877:
4876:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4835:
4834:
4833:
4828:
4823:
4818:
4808:
4807:
4806:
4801:
4796:
4791:
4786:
4781:
4776:
4771:
4760:
4758:
4757:(EC 2.7.11.25)
4751:
4750:
4748:
4747:
4746:
4745:
4740:
4735:
4725:
4724:
4723:
4718:
4713:
4703:
4702:
4701:
4696:
4691:
4686:
4681:
4676:
4671:
4660:
4658:
4657:(EC 2.7.11.24)
4651:
4650:
4648:
4647:
4642:
4637:
4632:
4627:
4622:
4617:
4612:
4607:
4601:
4599:
4598:(EC 2.7.11.23)
4592:
4591:
4589:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4492:
4490:
4489:(EC 2.7.11.22)
4483:
4482:
4480:
4479:
4474:
4469:
4464:
4458:
4456:
4455:(EC 2.7.11.21)
4445:
4444:
4438:
4431:
4430:
4427:
4426:
4423:
4422:
4420:
4419:
4414:
4409:
4404:
4398:
4396:
4395:(EC 2.7.11.21)
4389:
4388:
4386:
4385:
4380:
4374:
4372:
4371:(EC 2.7.11.20)
4365:
4364:
4362:
4361:
4356:
4351:
4346:
4341:
4335:
4333:
4332:(EC 2.7.11.19)
4326:
4325:
4323:
4322:
4317:
4312:
4307:
4301:
4299:
4298:(EC 2.7.11.18)
4292:
4291:
4289:
4288:
4283:
4278:
4273:
4268:
4263:
4258:
4253:
4248:
4243:
4238:
4233:
4228:
4223:
4218:
4213:
4208:
4203:
4198:
4193:
4188:
4183:
4178:
4173:
4168:
4163:
4158:
4153:
4148:
4143:
4138:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4098:
4093:
4088:
4083:
4078:
4073:
4068:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4023:
4018:
4013:
4007:
4005:
4004:(EC 2.7.11.17)
3998:
3997:
3995:
3994:
3989:
3984:
3978:
3976:
3975:(EC 2.7.11.16)
3969:
3968:
3966:
3965:
3960:
3954:
3952:
3951:(EC 2.7.11.15)
3945:
3944:
3942:
3941:
3935:
3933:
3932:(EC 2.7.11.14)
3926:
3925:
3923:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3872:
3867:
3862:
3856:
3854:
3853:(EC 2.7.11.13)
3847:
3846:
3844:
3843:
3838:
3832:
3830:
3829:(EC 2.7.11.12)
3823:
3822:
3820:
3819:
3814:
3809:
3804:
3799:
3793:
3791:
3790:(EC 2.7.11.11)
3784:
3783:
3781:
3780:
3775:
3770:
3765:
3760:
3755:
3749:
3747:
3746:(EC 2.7.11.10)
3740:
3739:
3737:
3736:
3732:
3730:
3723:
3722:
3720:
3719:
3714:
3708:
3706:
3699:
3698:
3696:
3695:
3694:
3693:
3688:
3683:
3672:
3670:
3663:
3662:
3660:
3659:
3653:
3651:
3644:
3643:
3641:
3640:
3635:
3630:
3625:
3619:
3617:
3610:
3609:
3607:
3606:
3601:
3596:
3590:
3588:
3581:
3580:
3578:
3577:
3576:
3575:
3570:
3565:
3557:
3556:
3555:
3550:
3542:
3541:
3540:
3535:
3523:
3521:
3514:
3513:
3511:
3510:
3505:
3500:
3495:
3489:
3487:
3480:
3479:
3477:
3476:
3475:
3474:
3464:
3463:
3462:
3457:
3452:
3447:
3437:
3432:
3427:
3426:
3425:
3420:
3415:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3349:
3347:
3336:
3335:
3329:
3322:
3321:
3307:
3305:
3304:
3297:
3290:
3282:
3275:
3274:
3239:
3204:
3161:
3124:
3081:
3046:
3011:
2966:
2940:(5): 491–496.
2929:
2900:
2865:
2830:
2787:
2758:
2730:(6): 853–862.
2715:
2679:
2677:
2674:
2671:
2670:
2613:
2594:(4): 481–498.
2578:
2557:(4): 362–370.
2537:
2485:
2460:
2411:
2365:
2316:
2275:
2226:
2177:
2118:
2089:(2): 223–234.
2069:
2040:(2): 288–289.
2020:
1966:
1912:
1860:
1804:
1785:
1735:
1717:
1699:
1678:
1656:
1655:
1653:
1650:
1649:
1648:
1641:
1638:
1616:Inhibition of
1594:, sympathetic
1571:
1568:
1551:
1550:
1544:
1538:
1532:
1525:
1516:
1513:
1487:TBK1 promotes
1482:growth factors
1478:ubiquitination
1415:
1349:
1346:
1296:phosphorylates
1291:
1288:
1227:
1226:
1223:
1222:
1217:
1207:
1206:
1200:
1199:
1196:
1195:
1193:
1191:
1184:
1183:
1176:
1169:
1165:
1164:
1161:
1160:
1150:
1149:
1143:
1140:
1139:
1129:
1128:
1122:
1118:
1117:
1114:
1113:
1103:
1102:
1096:
1093:
1092:
1082:
1081:
1075:
1071:
1070:
1067:
1066:
1058:
1057:
1051:
1048:
1047:
1039:
1038:
1032:
1026:
1025:
1022:
1021:
1013:
1012:
1006:
1003:
1002:
994:
993:
987:
981:
980:
977:
976:
968:
967:
961:
958:
957:
949:
948:
942:
936:
935:
930:
925:
921:
920:
910:
909:
906:
905:
894:
893:
891:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
729:
727:
723:
722:
720:
719:
714:
709:
704:
699:
693:
691:
687:
686:
684:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
627:
625:
621:
620:
610:
609:
606:
605:
602:
601:
593:
592:
581:
575:
574:
571:
570:
562:
561:
558:
557:
555:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
511:
510:
499:
496:
495:
493:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
449:
448:
436:
435:
427:
416:
410:
409:
406:RNA expression
398:
397:
394:
393:
385:
381:
380:
372:
369:
364:
358:
357:
348:
341:
335:
331:
330:
325:
319:
318:
310:
309:
297:
296:
293:
292:
284:
280:
279:
271:
268:
263:
257:
256:
247:
240:
234:
230:
229:
222:
216:
215:
207:
206:
194:
193:
150:
146:
145:
137:
129:
128:
124:
123:
120:
119:
116:
115:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
5474:
5463:
5460:
5458:
5455:
5454:
5452:
5442:
5437:
5432:
5428:
5414:
5410:
5409:
5404:
5401:
5397:
5396:
5391:
5388:
5384:
5383:
5378:
5375:
5371:
5370:
5365:
5362:
5358:
5357:
5352:
5349:
5345:
5344:
5339:
5336:
5332:
5331:
5326:
5325:
5323:
5319:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5289:
5287:
5283:
5277:
5274:
5272:
5271:Enzyme family
5269:
5267:
5264:
5262:
5259:
5258:
5256:
5252:
5246:
5243:
5241:
5238:
5236:
5235:Cooperativity
5233:
5231:
5228:
5227:
5225:
5221:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5197:
5195:
5194:Oxyanion hole
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5176:
5174:
5170:
5166:
5159:
5154:
5152:
5147:
5145:
5140:
5139:
5136:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5098:
5096:
5093:
5091:
5088:
5086:
5083:
5082:
5080:
5078:
5074:
5070:
5065:
5060:
5056:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5005:
5002:
5000:
4997:
4995:
4992:
4990:
4987:
4986:
4985:
4982:
4981:
4979:
4976:
4972:
4965:
4964:
4962:
4959:
4955:
4948:
4947:
4945:
4942:
4938:
4931:
4930:
4928:
4925:
4921:
4915:
4912:
4910:
4907:
4905:
4902:
4901:
4899:
4896:
4892:
4886:
4883:
4881:
4878:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4840:
4839:
4836:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4813:
4812:
4809:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4766:
4765:
4762:
4761:
4759:
4756:
4752:
4744:
4741:
4739:
4736:
4734:
4731:
4730:
4729:
4726:
4722:
4719:
4717:
4714:
4712:
4709:
4708:
4707:
4704:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4666:
4665:
4662:
4661:
4659:
4656:
4652:
4646:
4643:
4641:
4638:
4636:
4633:
4631:
4628:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4602:
4600:
4597:
4593:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4493:
4491:
4488:
4484:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4460:
4459:
4457:
4454:
4450:
4446:
4441:
4436:
4432:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4399:
4397:
4394:
4390:
4384:
4381:
4379:
4376:
4375:
4373:
4370:
4366:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4336:
4334:
4331:
4327:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4302:
4300:
4297:
4293:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4234:
4232:
4229:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4169:
4167:
4164:
4162:
4159:
4157:
4154:
4152:
4149:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4008:
4006:
4003:
3999:
3993:
3990:
3988:
3985:
3983:
3980:
3979:
3977:
3974:
3970:
3964:
3961:
3959:
3956:
3955:
3953:
3950:
3946:
3940:
3937:
3936:
3934:
3931:
3927:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3857:
3855:
3852:
3848:
3842:
3839:
3837:
3834:
3833:
3831:
3828:
3824:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3794:
3792:
3789:
3785:
3779:
3776:
3774:
3771:
3769:
3766:
3764:
3761:
3759:
3756:
3754:
3751:
3750:
3748:
3745:
3741:
3734:
3733:
3731:
3729:(EC 2.7.11.9)
3728:
3724:
3718:
3715:
3713:
3710:
3709:
3707:
3705:(EC 2.7.11.8)
3704:
3700:
3692:
3689:
3687:
3684:
3682:
3679:
3678:
3677:
3676:Aurora kinase
3674:
3673:
3671:
3669:(EC 2.7.11.7)
3668:
3664:
3658:
3655:
3654:
3652:
3650:(EC 2.7.11.6)
3649:
3645:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3620:
3618:
3616:(EC 2.7.11.5)
3615:
3611:
3605:
3602:
3600:
3597:
3595:
3592:
3591:
3589:
3587:(EC 2.7.11.4)
3586:
3582:
3574:
3571:
3569:
3566:
3564:
3561:
3560:
3558:
3554:
3551:
3549:
3546:
3545:
3543:
3539:
3536:
3534:
3531:
3530:
3528:
3525:
3524:
3522:
3520:(EC 2.7.11.3)
3519:
3515:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3490:
3488:
3486:(EC 2.7.11.2)
3485:
3481:
3473:
3470:
3469:
3468:
3465:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3442:
3441:
3440:EIF-2 kinases
3438:
3436:
3433:
3431:
3428:
3424:
3421:
3419:
3416:
3414:
3411:
3410:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3350:
3348:
3346:(EC 2.7.11.1)
3345:
3341:
3337:
3332:
3327:
3323:
3318:
3314:
3310:
3303:
3298:
3296:
3291:
3289:
3284:
3283:
3280:
3271:
3267:
3262:
3257:
3253:
3249:
3245:
3240:
3236:
3232:
3227:
3222:
3218:
3214:
3210:
3205:
3201:
3197:
3192:
3187:
3183:
3179:
3175:
3171:
3167:
3162:
3158:
3154:
3150:
3146:
3142:
3138:
3135:(2): 97–105.
3134:
3130:
3125:
3121:
3117:
3112:
3107:
3103:
3099:
3095:
3091:
3087:
3082:
3078:
3074:
3069:
3064:
3060:
3056:
3052:
3047:
3043:
3039:
3034:
3029:
3025:
3021:
3017:
3012:
3008:
3004:
3000:
2996:
2992:
2988:
2984:
2980:
2976:
2972:
2967:
2963:
2959:
2955:
2951:
2947:
2946:10.1038/ni921
2943:
2939:
2935:
2930:
2926:
2922:
2918:
2914:
2910:
2906:
2901:
2897:
2893:
2888:
2883:
2879:
2875:
2871:
2866:
2862:
2858:
2853:
2848:
2844:
2840:
2836:
2831:
2827:
2823:
2818:
2813:
2809:
2805:
2801:
2797:
2793:
2788:
2784:
2780:
2776:
2772:
2768:
2764:
2759:
2755:
2751:
2747:
2743:
2738:
2733:
2729:
2725:
2721:
2716:
2712:
2708:
2703:
2698:
2694:
2690:
2686:
2681:
2680:
2675:
2666:
2662:
2657:
2652:
2648:
2644:
2640:
2636:
2632:
2628:
2624:
2617:
2614:
2609:
2605:
2601:
2597:
2593:
2589:
2582:
2579:
2574:
2570:
2565:
2560:
2556:
2552:
2548:
2541:
2538:
2533:
2529:
2524:
2519:
2515:
2511:
2507:
2503:
2499:
2492:
2490:
2486:
2474:
2470:
2464:
2461:
2456:
2452:
2447:
2442:
2438:
2434:
2430:
2426:
2422:
2415:
2412:
2407:
2403:
2399:
2395:
2391:
2387:
2384:(2): 97–105.
2383:
2379:
2372:
2370:
2366:
2361:
2357:
2352:
2347:
2343:
2339:
2335:
2331:
2327:
2320:
2317:
2312:
2308:
2303:
2298:
2294:
2290:
2286:
2279:
2276:
2271:
2267:
2262:
2257:
2253:
2249:
2246:(1): e48317.
2245:
2241:
2237:
2230:
2227:
2222:
2218:
2213:
2208:
2204:
2200:
2196:
2192:
2188:
2181:
2178:
2173:
2169:
2164:
2159:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2122:
2119:
2114:
2110:
2105:
2100:
2096:
2092:
2088:
2084:
2080:
2073:
2070:
2065:
2061:
2057:
2053:
2048:
2043:
2039:
2035:
2031:
2024:
2021:
2016:
2012:
2007:
2002:
1997:
1992:
1988:
1984:
1980:
1973:
1971:
1967:
1962:
1958:
1953:
1948:
1943:
1938:
1934:
1930:
1926:
1919:
1917:
1913:
1908:
1904:
1899:
1894:
1890:
1886:
1882:
1878:
1874:
1867:
1865:
1861:
1856:
1852:
1847:
1842:
1837:
1832:
1828:
1824:
1820:
1813:
1811:
1809:
1805:
1800:
1794:
1792:
1790:
1786:
1781:
1777:
1772:
1767:
1763:
1759:
1755:
1748:
1746:
1744:
1742:
1740:
1736:
1731:
1727:
1721:
1718:
1713:
1709:
1703:
1700:
1696:
1692:
1687:
1685:
1683:
1679:
1675:
1671:
1666:
1664:
1662:
1658:
1651:
1647:
1644:
1643:
1639:
1637:
1635:
1631:
1627:
1623:
1619:
1614:
1611:
1609:
1605:
1601:
1597:
1593:
1589:
1585:
1584:tumorogenesis
1581:
1580:cell survival
1577:
1569:
1567:
1565:
1561:
1557:
1548:
1545:
1542:
1539:
1536:
1533:
1530:
1527:
1526:
1524:
1522:
1514:
1512:
1510:
1506:
1502:
1498:
1494:
1493:mitochondrial
1490:
1485:
1483:
1479:
1475:
1471:
1466:
1464:
1460:
1456:
1452:
1448:
1444:
1439:
1437:
1433:
1429:
1413:
1406:
1402:
1397:
1395:
1394:endolysosomes
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1347:
1345:
1343:
1339:
1335:
1330:
1328:
1324:
1320:
1316:
1312:
1311:kinase domain
1308:
1303:
1301:
1297:
1289:
1287:
1285:
1284:tumorigenesis
1281:
1277:
1273:
1269:
1265:
1261:
1257:
1253:
1249:
1245:
1241:
1237:
1233:
1221:
1216:
1212:
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1194:
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1189:
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1174:
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1166:
1159:
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1151:
1147:
1144:
1138:
1136:
1130:
1126:
1123:
1119:
1112:
1110:
1104:
1100:
1097:
1091:
1089:
1083:
1079:
1076:
1074:RefSeq (mRNA)
1072:
1065:
1064:
1059:
1055:
1052:
1046:
1045:
1040:
1036:
1033:
1031:
1027:
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1019:
1014:
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1007:
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986:
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965:
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849:
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844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
813:viral process
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
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771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
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741:
739:
736:
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664:
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649:
647:
644:
642:
639:
637:
634:
632:
629:
628:
626:
623:
622:
619:
618:Gene ontology
615:
611:
599:
594:
590:
585:
582:
580:
576:
568:
563:
552:
548:
544:
540:
536:
532:
528:
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508:
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425:
421:
420:
417:
415:
411:
407:
403:
399:
391:
386:
382:
378:
373:
367:10|10 D2
363:
359:
352:
345:
339:
332:
324:
320:
316:
311:
307:
302:
298:
290:
285:
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96:
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88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
5408:Translocases
5405:
5392:
5379:
5366:
5353:
5343:Transferases
5340:
5327:
5184:Binding site
4615:P70S6 kinase
3762:
3251:
3247:
3216:
3212:
3173:
3169:
3132:
3128:
3093:
3089:
3058:
3054:
3023:
3019:
2974:
2970:
2937:
2933:
2908:
2904:
2877:
2873:
2842:
2838:
2799:
2795:
2766:
2762:
2727:
2723:
2692:
2688:
2630:
2626:
2616:
2591:
2587:
2581:
2554:
2550:
2540:
2505:
2501:
2476:. Retrieved
2472:
2463:
2428:
2424:
2414:
2381:
2377:
2333:
2329:
2319:
2292:
2288:
2278:
2243:
2240:EMBO Reports
2239:
2229:
2194:
2190:
2180:
2135:
2131:
2121:
2086:
2082:
2072:
2037:
2033:
2023:
1986:
1982:
1932:
1928:
1883:(1): 83–90.
1880:
1876:
1826:
1822:
1761:
1758:FEBS Letters
1757:
1729:
1720:
1711:
1702:
1615:
1612:
1610:) diseases.
1573:
1553:
1518:
1515:Interactions
1511:metabolism.
1486:
1467:
1440:
1398:
1351:
1331:
1304:
1293:
1282:diseases or
1231:
1230:
1153:
1132:
1106:
1085:
1061:
1042:
1016:
997:
971:
952:
932:
927:
429:
422:
388:121,422,692
375:121,382,360
149:External IDs
72:
5179:Active site
5066:(EC 2.7.12)
4453:Polo kinase
4393:Polo kinase
1549:aka SINTBAD
1447:p100/NF-κB2
1370:interferons
1323:coiled-coil
1270:, and anti-
712:nucleoplasm
666:ATP binding
517:Paneth cell
479:sural nerve
287:64,502,114
274:64,452,090
127:Identifiers
5451:Categories
5382:Isomerases
5356:Hydrolases
5223:Regulation
3744:IκB kinase
3319:2.7.11-12)
1989:(9): 139.
1697:, May 2017
1676:, May 2017
1652:References
1618:IκB kinase
1588:autoimmune
1451:proteasome
1362:substrates
1319:C-terminus
1307:N-terminus
1276:autoimmune
433:(ortholog)
170:HomoloGene
5462:EC 2.7.11
5261:EC number
3870:PKC alpha
2911:: 57–64.
2034:Autophagy
1576:mutations
1505:apoptosis
1497:autophagy
1489:autophagy
1474:cytoplasm
1459:dimerizes
1414:ϵ
1386:autophagy
1382:cytoplasm
1315:ubiquitin
1268:autophagy
1264:apoptosis
1248:threonine
1156:NP_062760
1135:NP_037386
1109:NM_019786
1088:NM_013254
918:Orthologs
717:aggresome
697:cytoplasm
178:GeneCards
5285:Kinetics
5209:Cofactor
5172:Activity
4226:KIAA0999
4121:MAPKAPK5
4116:MAPKAPK3
4111:MAPKAPK2
3270:15489227
3235:15485837
3200:15367631
3157:11683986
3149:14743216
3120:14560022
3077:14530355
3042:12761501
3020:Oncogene
3007:42641584
2999:12702806
2962:19867234
2954:12692549
2925:12568715
2896:12133833
2861:11839743
2826:10990461
2665:36634707
2656:10171827
2608:24237125
2573:24468793
2532:17599067
2455:10990461
2406:11683986
2398:14743216
2360:10581243
2270:31709703
2221:30827897
2172:27035970
2113:22921120
2083:Immunity
2056:20104023
2015:30223576
1961:28148298
1935:(1): 5.
1907:29218456
1855:29559975
1780:23395801
1693:–
1672:–
1640:See also
1521:interact
1204:Wikidata
897:Sources:
475:monocyte
5441:Biology
5395:Ligases
5165:Enzymes
4885:MAP3K14
4863:MAP3K11
4858:MAP3K10
4848:MAP3K13
4843:MAP3K12
4645:RPS6KC1
4640:RPS6KA1
4635:RPS6KA3
4630:RPS6KA2
4625:RPS6KB2
4610:RPS6KA4
4605:RPS6KA5
4256:Kalirin
4221:SNF1LK2
3460:EIF2AK4
3455:EIF2AK3
3309:Kinases
2979:Bibcode
2971:Science
2783:9721103
2763:Science
2746:8601309
2711:7706279
2635:Bibcode
2523:1933404
2473:UniProt
2351:1171732
2311:7706279
2261:6945063
2212:6907693
2163:4839414
2140:Bibcode
2104:3428731
2064:1059428
2006:6162516
1952:5288885
1898:5842199
1846:5845716
1829:: 434.
1695:Ensembl
1674:Ensembl
1602:(e.g.,
1590:(e.g.,
1509:glucose
1436:nucleus
1378:SINTBAD
1342:lysines
1030:UniProt
985:Ensembl
924:Species
903:QuickGO
702:cytosol
525:condyle
408:pattern
266:12q14.2
166:1929658
134:Aliases
5427:Portal
5369:Lyases
5115:MAP2K7
5110:MAP2K6
5105:MAP2K5
5100:MAP2K4
5095:MAP2K3
5090:MAP2K2
5085:MAP2K1
5036:ACVRL1
5031:ACVR2B
5026:ACVR2A
5021:ACVR1C
5016:ACVR1B
4999:BMPR1B
4994:BMPR1A
4868:MAP3K7
4853:MAP3K9
4804:MAP3K8
4799:MAP3K7
4794:MAP3K6
4789:MAP3K5
4784:MAP3K4
4779:MAP3K3
4774:MAP3K2
4769:MAP3K1
4743:MAPK14
4738:MAPK13
4733:MAPK11
4721:MAPK10
4699:MAPK15
4694:MAPK12
4586:CDC2L1
4561:CDC2L5
4236:SNF1LK
4061:CAMK2G
4056:CAMK2D
4051:CAMK2B
4046:CAMK2A
4036:CAMK1G
4031:CAMK1D
4026:CAMK1B
4021:CAMK1A
3875:PRKCB1
3812:PRKACA
3807:PRKACB
3802:PRKACG
3778:IKBKAP
3604:BCKDHB
3599:BCKDHA
3573:PRKAG3
3568:PRKAG2
3563:PRKAG1
3553:PRKAB2
3548:PRKAB1
3538:PRKAA2
3533:PRKAA1
3378:STK38L
3268:
3233:
3198:
3191:516426
3188:
3155:
3147:
3118:
3111:207563
3108:
3075:
3040:
3005:
2997:
2960:
2952:
2923:
2894:
2859:
2824:
2817:314216
2814:
2781:
2754:112412
2752:
2744:
2709:
2663:
2653:
2627:Nature
2606:
2571:
2530:
2520:
2478:30 Jun
2453:
2446:314216
2443:
2404:
2396:
2358:
2348:
2309:
2268:
2258:
2219:
2209:
2170:
2160:
2111:
2101:
2062:
2054:
2013:
2003:
1959:
1949:
1905:
1895:
1853:
1843:
1778:
1630:cancer
1547:TBKBP1
1523:with:
1338:serine
1244:serine
1240:kinase
1236:enzyme
1234:is an
1190:search
1188:PubMed
1063:Q9WUN2
1044:Q9UHD2
940:Entrez
579:BioGPS
487:tonsil
158:604834
5321:Types
5077:MAP2K
5011:ACVR1
5004:BMPR2
4989:BMPR1
4914:GSK-3
4755:MAP3K
4716:MAPK9
4711:MAPK8
4689:MAPK7
4684:MAPK6
4679:MAPK4
4674:MAPK3
4669:MAPK1
4581:PFTK1
4576:PCTK3
4571:PCTK2
4566:PCTK1
4556:CDK12
4551:CDK10
4526:CDKL5
4506:CDKL2
4383:STK19
4378:EEF2K
4359:PHKG2
4354:PHKG1
4344:PHKA2
4339:PHKA1
4320:MYLK4
4315:MYLK3
4310:MYLK2
4286:DCLK1
4281:Titin
4271:TRIB3
4266:TRIB2
4261:TRIB1
4251:TSSK2
4231:STK40
4216:PSKH1
4211:PRKD3
4206:PRKD2
4186:PHKG2
4181:PHKG1
4171:OBSCN
4166:NUAK2
4161:NUAK1
4156:MKNK2
4151:MKNK1
4141:MARK4
4136:MARK3
4131:MARK2
4126:MARK1
4106:STK11
4101:DAPK3
4096:DAPK2
4091:DAPK1
4086:CHEK2
4081:CHEK1
4066:CAMK4
4041:CAMK2
4016:CAMK1
4011:BRSK2
3905:PRKCQ
3900:PRKCI
3895:PRKCG
3890:PRKCH
3885:PRKCE
3880:PRKCD
3841:PRKG1
3773:IKBKG
3768:IKBKE
3717:STK10
3712:FASTK
3638:IDH3G
3633:IDH3B
3628:IDH3A
3594:BCKDK
3388:ROCK1
3373:STK38
3368:MAST2
3363:MAST1
3358:LATS2
3353:LATS1
3153:S2CID
3003:S2CID
2958:S2CID
2750:S2CID
2402:S2CID
2060:S2CID
1983:Cells
1622:IKBKE
1596:lupus
1541:TRAF2
1272:tumor
1238:with
973:56480
954:29110
933:Mouse
928:Human
899:Amigo
533:fossa
471:sperm
431:Mouse
424:Human
371:Start
306:Mouse
270:Start
203:Human
174:22742
5413:list
5406:EC7
5400:list
5393:EC6
5387:list
5380:EC5
5374:list
5367:EC4
5361:list
5354:EC3
5348:list
5341:EC2
5335:list
5328:EC1
4904:TPK1
4880:CDC7
4838:MLKs
4831:KSR2
4826:KSR1
4821:BRAF
4816:ARAF
4811:RAFs
4546:CDK9
4541:CDK8
4536:CDK7
4531:CDK6
4521:CDK5
4516:CDK4
4511:CDK3
4501:CDK2
4496:CDK1
4477:PLK4
4472:PLK3
4467:PLK2
4462:PLK1
4417:PLK4
4412:PLK3
4407:PLK2
4402:PLK1
4349:PHKB
4305:MYLK
4276:TRIO
4246:SPEG
4241:SNRK
4201:PKD1
4196:PIM2
4191:PIM1
4176:PASK
4146:MELK
4076:CASK
4071:MLCK
3992:GRK6
3987:GRK5
3982:GRK4
3920:PKN3
3915:PKN2
3817:PRKY
3763:TBK1
3758:IKK2
3753:CHUK
3657:STK4
3623:IDH2
3508:PDK4
3503:PDK3
3498:PDK2
3493:PDK1
3472:WEE1
3467:Wee1
3435:mTOR
3423:AKT3
3418:AKT2
3413:AKT1
3403:SGK3
3398:SGK2
3266:PMID
3231:PMID
3196:PMID
3145:PMID
3116:PMID
3073:PMID
3038:PMID
2995:PMID
2950:PMID
2921:PMID
2905:Gene
2892:PMID
2857:PMID
2822:PMID
2779:PMID
2742:PMID
2724:Cell
2707:PMID
2661:PMID
2604:PMID
2569:PMID
2528:PMID
2480:2018
2451:PMID
2394:PMID
2356:PMID
2307:PMID
2266:PMID
2217:PMID
2168:PMID
2109:PMID
2052:PMID
2011:PMID
1957:PMID
1903:PMID
1851:PMID
1776:PMID
1628:and
1564:ZEB1
1562:and
1560:IRF7
1556:IRF3
1535:TANK
1529:NCK1
1507:and
1443:NFkB
1432:IRF3
1390:TAPE
1376:and
1374:NAP1
1332:The
1305:The
1252:gene
545:iris
414:Bgee
362:Band
323:Chr.
261:Band
220:Chr.
182:TBK1
154:OMIM
141:TBK1
111:4IWQ
107:4IWP
103:4IWO
99:4IW0
95:4IM3
91:4IM2
87:4IM0
83:4EUU
79:4EUT
75:4EFO
56:RCSB
53:PDBe
22:TBK1
4909:TTK
4873:ZAK
3450:HRI
3445:PKR
3393:SGK
3383:CIT
3256:doi
3252:279
3221:doi
3217:279
3186:PMC
3178:doi
3137:doi
3106:PMC
3098:doi
3063:doi
3059:171
3028:doi
2987:doi
2975:300
2942:doi
2913:doi
2909:304
2882:doi
2878:277
2847:doi
2843:277
2812:PMC
2804:doi
2771:doi
2767:281
2732:doi
2697:doi
2693:270
2651:PMC
2643:doi
2631:615
2596:doi
2559:doi
2518:PMC
2510:doi
2441:PMC
2433:doi
2386:doi
2346:PMC
2338:doi
2297:doi
2293:270
2256:PMC
2248:doi
2207:PMC
2199:doi
2158:PMC
2148:doi
2136:113
2099:PMC
2091:doi
2042:doi
2001:PMC
1991:doi
1947:PMC
1937:doi
1893:PMC
1885:doi
1841:PMC
1831:doi
1766:doi
1762:587
1598:),
1543:and
1470:IKB
1455:p52
1405:IKK
1336:of
384:End
283:End
186:OMA
162:MGI
46:PDB
5453::
3559:γ
3544:β
3529:α
3317:EC
3311::
3264:.
3250:.
3246:.
3229:.
3215:.
3211:.
3194:.
3184:.
3174:78
3172:.
3168:.
3151:.
3143:.
3131:.
3114:.
3104:.
3094:23
3092:.
3088:.
3071:.
3057:.
3053:.
3036:.
3024:22
3022:.
3018:.
3001:.
2993:.
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2956:.
2948:.
2936:.
2919:.
2907:.
2890:.
2876:.
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2855:.
2841:.
2837:.
2820:.
2810:.
2800:19
2798:.
2794:.
2777:.
2765:.
2748:.
2740:.
2728:84
2726:.
2722:.
2705:.
2691:.
2687:.
2659:.
2649:.
2641:.
2629:.
2625:.
2602:.
2590:.
2567:.
2555:94
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2549:.
2526:.
2516:.
2506:26
2504:.
2500:.
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2471:.
2449:.
2439:.
2429:19
2427:.
2423:.
2400:.
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2344:.
2334:18
2332:.
2328:.
2305:.
2291:.
2287:.
2264:.
2254:.
2244:21
2242:.
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2193:.
2189:.
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1981:.
1969:^
1955:.
1945:.
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1901:.
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1881:12
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1774:.
1760:.
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1636:.
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1484:.
1465:.
1396:.
1329:.
1286:.
1278:,
1266:,
1262:,
1246:/
901:/
390:bp
377:bp
289:bp
276:bp
184:;
180::
176:;
172::
168:;
164::
160:;
156::
109:,
105:,
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2017:.
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1963:.
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