314:
291:
188:
213:
565:
1746:
320:
219:
1776:
1761:
29:
1731:
1804:
55:
1085:
residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave
327:
226:
748:
729:
149:
1873:
1849:
1868:
1710:
1206:
1188:
1745:
1775:
1760:
1551:"Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization"
313:
1003:
996:
290:
1276:
1175:
1154:
212:
187:
1730:
1171:
52:
1150:
129:
1109:
Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
326:
225:
1842:
1341:"Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis"
319:
218:
1703:
1099:
1095:
793:
137:
1473:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
774:
1835:
201:
1696:
1658:
1605:
116:
1290:
Oyama, T; Sasagawa, S; Takeda, S; Hess, R. A.; Lieberman, P. M.; Cheng, E. H.; Hsieh, J. J. (2013).
975:
971:
967:
942:
938:
934:
904:
900:
896:
875:
871:
867:
1255:
161:
1594:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1339:
Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ (July 2010).
979:
946:
908:
863:
1676:
1633:
1580:
1537:
1502:
1459:
1424:
1370:
1321:
1247:
109:
45:
1819:
1226:"Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression"
1666:
1623:
1613:
1570:
1562:
1527:
1492:
1484:
1449:
1414:
1406:
1360:
1352:
1311:
1303:
1237:
406:
337:
281:
236:
564:
157:
1292:"Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs"
1103:
381:
1662:
1609:
1438:"Crystal structure of human Taspase1, a crucial protease regulating the function of MLL"
1419:
1394:
1365:
1340:
1316:
1291:
28:
1628:
1593:
1575:
1550:
1497:
1472:
1242:
1225:
663:
658:
653:
637:
621:
616:
611:
606:
1862:
1815:
1082:
1078:
593:
1410:
1259:
141:
399:
178:
1566:
1356:
1307:
165:
1211:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1193:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1122:
482:
1454:
1437:
1087:
298:
195:
145:
1516:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1126:
693:
542:
420:
365:
352:
264:
251:
153:
1680:
1637:
1618:
1584:
1541:
1506:
1463:
1428:
1374:
1325:
1251:
1129:. Therefore, Taspase1 may serve as a novel anti-cancer therapeutic target.
1395:"Uncleaved TFIIA is a substrate for taspase 1 and active in transcription"
1117:
Taspase1 is overexpressed in primary human cancers and functions as a non-
1043:
1038:
1118:
1091:
1027:
838:
819:
1488:
805:
760:
86:
82:
78:
74:
1059:
1011:
715:
1803:
1671:
1646:
1532:
1515:
1647:"The DNA sequence and comparative analysis of human chromosome 20"
678:
674:
1811:
1066:
573:
133:
1692:
1688:
1549:
Hsieh JJ, Ernst P, Erdjument-Bromage H, et al. (2003).
1592:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1645:
Deloukas P, Matthews LH, Ashurst J, et al. (2002).
389:
1823:
1471:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1754:: Crystal Structure of human Taspase1 (acivated form)
554:
1784:: Crystal Structure of Human Taspase1 (T234S mutant)
1769:: Crystal structure of Human Taspase1 (T234A mutant)
1277:"Entrez Gene: TASP1 taspase, threonine aspartase, 1"
1393:Zhou H, Spicuglia S, Hsieh JJ, et al. (2006).
960:
927:
889:
856:
654:
positive regulation of transcription, DNA-templated
517:
dentate gyrus of hippocampal formation granule cell
1514:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1167:
1165:
1163:
1146:
1144:
1142:
336:
235:
16:Protein-coding gene in the species Homo sapiens
1172:GRCm38: Ensembl release 89: ENSMUSG00000039033
1843:
1704:
1224:Hsieh JJ, Cheng EH, Korsmeyer SJ (Nov 2003).
8:
1098:, a basal transcription factor. Cleavage of
1090:, a protein required for the maintenance of
1151:GRCh38: Ensembl release 89: ENSG00000089123
1121:addiction protease that coordinates cancer
1081:that cleaves specific substrates following
1850:
1836:
1711:
1697:
1689:
689:
589:
377:
276:
173:
63:
1670:
1627:
1617:
1574:
1531:
1496:
1453:
1418:
1364:
1315:
1241:
120:, C20orf13, dJ585I14.2, taspase 1, SULEHS
1271:
1269:
1726:
1138:
18:
1739:: Crystal Structure of human Taspase1
617:threonine-type endopeptidase activity
341:
302:
297:
240:
199:
194:
7:
1800:
1798:
1822:. You can help Knowledge (XXG) by
957:
924:
886:
853:
829:
810:
784:
765:
739:
720:
559:
477:
415:
394:
14:
1436:Khan JA, Dunn BM, Tong L (2006).
1062:that in humans is encoded by the
1802:
1774:
1759:
1744:
1729:
563:
325:
318:
312:
289:
224:
217:
211:
186:
27:
1411:10.1128/MCB.26.7.2728-2735.2006
1874:Human chromosome 20 gene stubs
574:More reference expression data
543:More reference expression data
497:Region I of hippocampus proper
1:
1567:10.1128/MCB.23.1.186-194.2003
1357:10.1158/0008-5472.CAN-10-0027
1243:10.1016/S0092-8674(03)00816-X
310:
209:
1869:Genes on human chromosome 20
1598:Proc. Natl. Acad. Sci. U.S.A
1308:10.1016/j.devcel.2013.09.025
1890:
1797:
1724:
1455:10.1016/j.str.2005.07.006
1207:"Mouse PubMed Reference:"
1189:"Human PubMed Reference:"
1042:
1037:
1033:
1026:
1010:
1004:Chr 2: 139.68 – 139.91 Mb
991:
964:
931:
920:
893:
860:
849:
836:
832:
817:
813:
804:
791:
787:
772:
768:
759:
746:
742:
727:
723:
714:
699:
692:
688:
672:
622:identical protein binding
592:
588:
571:
562:
553:
540:
489:
480:
467:bronchial epithelial cell
455:Descending thoracic aorta
451:epithelium of nasopharynx
427:
418:
388:
380:
376:
359:
346:
309:
288:
279:
275:
258:
245:
208:
185:
176:
172:
127:
124:
114:
107:
102:
71:
66:
49:
44:
39:
35:
26:
21:
1102:has been found to drive
997:Chr 20: 13.39 – 13.64 Mb
1619:10.1073/pnas.242603899
1113:Clinical significance
1077:This gene encodes an
1056:Threonine aspartase 1
202:Chromosome 20 (human)
304:Chromosome 2 (mouse)
67:List of PDB id codes
40:Available structures
1663:2001Natur.414..865D
1610:2002PNAS...9916899M
1810:This article on a
1489:10.1101/gr.2596504
1296:Developmental Cell
1123:cell proliferation
794:ENSMUSG00000039033
664:protein maturation
647:Biological process
631:Cellular component
612:hydrolase activity
607:peptidase activity
600:Molecular function
1831:
1830:
1792:
1791:
1604:(26): 16899–903.
1053:
1052:
1049:
1048:
1022:
1021:
987:
986:
954:
953:
916:
915:
883:
882:
845:
844:
826:
825:
800:
799:
781:
780:
755:
754:
736:
735:
684:
683:
584:
583:
580:
579:
549:
548:
536:
535:
474:
473:
372:
371:
271:
270:
166:TASP1 - orthologs
98:
97:
94:
93:
50:Ortholog search:
1881:
1852:
1845:
1838:
1806:
1799:
1778:
1763:
1748:
1733:
1713:
1706:
1699:
1690:
1684:
1674:
1657:(6866): 865–71.
1641:
1631:
1621:
1588:
1578:
1545:
1535:
1510:
1500:
1467:
1457:
1432:
1422:
1379:
1378:
1368:
1336:
1330:
1329:
1319:
1287:
1281:
1280:
1273:
1264:
1263:
1245:
1221:
1215:
1214:
1203:
1197:
1196:
1185:
1179:
1169:
1158:
1148:
1094:expression, and
1035:
1034:
1006:
999:
982:
958:
949:
925:
921:RefSeq (protein)
911:
887:
878:
854:
830:
811:
785:
766:
740:
721:
690:
590:
576:
567:
560:
545:
485:
483:Top expressed in
478:
447:secondary oocyte
431:popliteal artery
423:
421:Top expressed in
416:
395:
378:
368:
355:
344:
329:
322:
316:
305:
293:
277:
267:
254:
243:
228:
221:
215:
204:
190:
174:
168:
119:
112:
89:
64:
58:
37:
36:
31:
19:
1889:
1888:
1884:
1883:
1882:
1880:
1879:
1878:
1859:
1858:
1857:
1856:
1795:
1793:
1788:
1785:
1779:
1770:
1764:
1755:
1749:
1740:
1734:
1720:
1717:
1687:
1672:10.1038/414865a
1644:
1591:
1555:Mol. Cell. Biol
1548:
1513:
1483:(10B): 2121–7.
1470:
1448:(10): 1443–52.
1435:
1399:Mol. Cell. Biol
1392:
1388:
1386:Further reading
1383:
1382:
1351:(13): 5358–67.
1338:
1337:
1333:
1289:
1288:
1284:
1275:
1274:
1267:
1223:
1222:
1218:
1205:
1204:
1200:
1187:
1186:
1182:
1170:
1161:
1149:
1140:
1135:
1115:
1104:spermatogenesis
1075:
1044:View/Edit Mouse
1039:View/Edit Human
1002:
995:
992:Location (UCSC)
978:
974:
970:
966:
945:
941:
937:
933:
907:
903:
899:
895:
874:
870:
866:
862:
775:ENSG00000089123
668:
642:
626:
572:
541:
532:
529:proximal tubule
527:
523:
519:
515:
511:
507:
503:
499:
495:
481:
470:
465:
463:ascending aorta
461:
457:
453:
449:
445:
443:Achilles tendon
441:
437:
435:tibial arteries
433:
419:
363:
350:
342:
332:
331:
330:
323:
303:
280:Gene location (
262:
249:
241:
231:
230:
229:
222:
200:
177:Gene location (
128:
115:
108:
73:
51:
17:
12:
11:
5:
1887:
1885:
1877:
1876:
1871:
1861:
1860:
1855:
1854:
1847:
1840:
1832:
1829:
1828:
1807:
1790:
1789:
1787:
1786:
1780:
1773:
1771:
1765:
1758:
1756:
1750:
1743:
1741:
1735:
1728:
1725:
1722:
1721:
1718:
1716:
1715:
1708:
1701:
1693:
1686:
1685:
1642:
1589:
1546:
1533:10.1038/ng1285
1511:
1468:
1433:
1405:(7): 2728–35.
1389:
1387:
1384:
1381:
1380:
1331:
1302:(2): 188–200.
1282:
1265:
1236:(3): 293–303.
1216:
1198:
1180:
1159:
1137:
1136:
1134:
1131:
1114:
1111:
1074:
1071:
1051:
1050:
1047:
1046:
1041:
1031:
1030:
1024:
1023:
1020:
1019:
1017:
1015:
1008:
1007:
1000:
993:
989:
988:
985:
984:
962:
961:
955:
952:
951:
929:
928:
922:
918:
917:
914:
913:
891:
890:
884:
881:
880:
858:
857:
851:
847:
846:
843:
842:
834:
833:
827:
824:
823:
815:
814:
808:
802:
801:
798:
797:
789:
788:
782:
779:
778:
770:
769:
763:
757:
756:
753:
752:
744:
743:
737:
734:
733:
725:
724:
718:
712:
711:
706:
701:
697:
696:
686:
685:
682:
681:
670:
669:
667:
666:
661:
656:
650:
648:
644:
643:
641:
640:
634:
632:
628:
627:
625:
624:
619:
614:
609:
603:
601:
597:
596:
586:
585:
582:
581:
578:
577:
569:
568:
557:
551:
550:
547:
546:
538:
537:
534:
533:
531:
530:
526:
522:
518:
514:
513:lacrimal gland
510:
506:
502:
498:
494:
490:
487:
486:
475:
472:
471:
469:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
425:
424:
412:
411:
403:
392:
386:
385:
382:RNA expression
374:
373:
370:
369:
361:
357:
356:
348:
345:
340:
334:
333:
324:
317:
311:
307:
306:
301:
295:
294:
286:
285:
273:
272:
269:
268:
260:
256:
255:
247:
244:
239:
233:
232:
223:
216:
210:
206:
205:
198:
192:
191:
183:
182:
170:
169:
126:
122:
121:
113:
105:
104:
100:
99:
96:
95:
92:
91:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1886:
1875:
1872:
1870:
1867:
1866:
1864:
1853:
1848:
1846:
1841:
1839:
1834:
1833:
1827:
1825:
1821:
1817:
1816:chromosome 20
1813:
1808:
1805:
1801:
1796:
1783:
1777:
1772:
1768:
1762:
1757:
1753:
1747:
1742:
1738:
1732:
1727:
1723:
1714:
1709:
1707:
1702:
1700:
1695:
1694:
1691:
1682:
1678:
1673:
1668:
1664:
1660:
1656:
1652:
1648:
1643:
1639:
1635:
1630:
1625:
1620:
1615:
1611:
1607:
1603:
1599:
1595:
1590:
1586:
1582:
1577:
1572:
1568:
1564:
1561:(1): 186–94.
1560:
1556:
1552:
1547:
1543:
1539:
1534:
1529:
1525:
1521:
1517:
1512:
1508:
1504:
1499:
1494:
1490:
1486:
1482:
1478:
1474:
1469:
1465:
1461:
1456:
1451:
1447:
1443:
1439:
1434:
1430:
1426:
1421:
1416:
1412:
1408:
1404:
1400:
1396:
1391:
1390:
1385:
1376:
1372:
1367:
1362:
1358:
1354:
1350:
1346:
1342:
1335:
1332:
1327:
1323:
1318:
1313:
1309:
1305:
1301:
1297:
1293:
1286:
1283:
1278:
1272:
1270:
1266:
1261:
1257:
1253:
1249:
1244:
1239:
1235:
1231:
1227:
1220:
1217:
1212:
1208:
1202:
1199:
1194:
1190:
1184:
1181:
1177:
1173:
1168:
1166:
1164:
1160:
1156:
1152:
1147:
1145:
1143:
1139:
1132:
1130:
1128:
1124:
1120:
1112:
1110:
1107:
1105:
1101:
1097:
1093:
1089:
1084:
1080:
1079:endopeptidase
1072:
1070:
1068:
1065:
1061:
1057:
1045:
1040:
1036:
1032:
1029:
1025:
1018:
1016:
1013:
1009:
1005:
1001:
998:
994:
990:
983:
981:
977:
973:
969:
963:
959:
956:
950:
948:
944:
940:
936:
930:
926:
923:
919:
912:
910:
906:
902:
898:
892:
888:
885:
879:
877:
873:
869:
865:
859:
855:
852:
850:RefSeq (mRNA)
848:
841:
840:
835:
831:
828:
822:
821:
816:
812:
809:
807:
803:
796:
795:
790:
786:
783:
777:
776:
771:
767:
764:
762:
758:
751:
750:
745:
741:
738:
732:
731:
726:
722:
719:
717:
713:
710:
707:
705:
702:
698:
695:
691:
687:
680:
676:
671:
665:
662:
660:
657:
655:
652:
651:
649:
646:
645:
639:
636:
635:
633:
630:
629:
623:
620:
618:
615:
613:
610:
608:
605:
604:
602:
599:
598:
595:
594:Gene ontology
591:
587:
575:
570:
566:
561:
558:
556:
552:
544:
539:
528:
524:
520:
516:
512:
508:
505:barrel cortex
504:
500:
496:
492:
491:
488:
484:
479:
476:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
429:
426:
422:
417:
414:
413:
410:
408:
404:
402:
401:
397:
396:
393:
391:
387:
383:
379:
375:
367:
362:
358:
354:
349:
339:
335:
328:
321:
315:
308:
300:
296:
292:
287:
283:
278:
274:
266:
261:
257:
253:
248:
238:
234:
227:
220:
214:
207:
203:
197:
193:
189:
184:
180:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
123:
118:
111:
106:
101:
90:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1824:expanding it
1809:
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1192:
1183:
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1108:
1076:
1063:
1055:
1054:
976:NP_001276540
972:NP_001153113
968:NP_001153112
965:
943:NP_001310533
939:NP_001310532
935:NP_001310531
932:
905:NM_001289611
901:NM_001159641
897:NM_001159640
894:
876:NM_001323604
872:NM_001323603
868:NM_001323602
861:
837:
818:
792:
773:
747:
728:
708:
703:
525:right kidney
509:spermatocyte
501:pineal gland
405:
398:
364:139,908,725
351:139,675,400
125:External IDs
72:
1719:PDB gallery
1526:(1): 40–5.
659:proteolysis
343:2|2 F3
263:13,638,932
250:13,389,392
103:Identifiers
1863:Categories
1520:Nat. Genet
1477:Genome Res
1345:Cancer Res
1178:, May 2017
1157:, May 2017
1133:References
409:(ortholog)
146:HomoloGene
1814:on human
1442:Structure
1127:apoptosis
1083:aspartate
980:NP_780434
947:NP_060184
909:NM_175225
864:NM_017714
694:Orthologs
638:cytoplasm
493:spermatid
154:GeneCards
1681:11780052
1638:12477932
1585:12482972
1542:14702039
1507:15489334
1464:16216576
1429:16537915
1375:20516119
1326:24176642
1260:18952302
1252:14636557
1174:–
1153:–
1119:oncogene
1092:HOX gene
1073:Function
1028:Wikidata
673:Sources:
439:testicle
1659:Bibcode
1606:Bibcode
1420:1430320
1366:2909739
1317:3947863
1176:Ensembl
1155:Ensembl
806:UniProt
761:Ensembl
700:Species
679:QuickGO
384:pattern
242:20p12.1
142:1923062
110:Aliases
1679:
1651:Nature
1636:
1629:139241
1626:
1583:
1576:140678
1573:
1540:
1505:
1498:528928
1495:
1462:
1427:
1417:
1373:
1363:
1324:
1314:
1258:
1250:
1060:enzyme
1058:is an
1014:search
1012:PubMed
839:Q8R1G1
820:Q9H6P5
716:Entrez
555:BioGPS
134:608270
1818:is a
1256:S2CID
1100:TFIIA
1096:TFIIA
1064:TASP1
749:75812
730:55617
709:Mouse
704:Human
675:Amigo
459:tibia
407:Mouse
400:Human
347:Start
282:Mouse
246:Start
179:Human
158:TASP1
117:TASP1
22:TASP1
1820:stub
1812:gene
1782:2a8m
1767:2a8l
1752:2a8j
1737:2a8i
1677:PMID
1634:PMID
1581:PMID
1538:PMID
1503:PMID
1460:PMID
1425:PMID
1371:PMID
1322:PMID
1248:PMID
1230:Cell
1125:and
1067:gene
521:lens
390:Bgee
338:Band
299:Chr.
237:Band
196:Chr.
150:9795
130:OMIM
87:2A8M
83:2A8L
79:2A8J
75:2A8I
56:RCSB
53:PDBe
1667:doi
1655:414
1624:PMC
1614:doi
1571:PMC
1563:doi
1528:doi
1493:PMC
1485:doi
1450:doi
1415:PMC
1407:doi
1361:PMC
1353:doi
1312:PMC
1304:doi
1238:doi
1234:115
1088:MLL
360:End
259:End
162:OMA
138:MGI
46:PDB
1865::
1675:.
1665:.
1653:.
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1632:.
1622:.
1612:.
1602:99
1600:.
1596:.
1579:.
1569:.
1559:23
1557:.
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1481:14
1479:.
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1458:.
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1423:.
1413:.
1403:26
1401:.
1397:.
1369:.
1359:.
1349:70
1347:.
1343:.
1320:.
1310:.
1300:27
1298:.
1294:.
1268:^
1254:.
1246:.
1232:.
1228:.
1209:.
1191:.
1162:^
1141:^
1106:.
1069:.
677:/
366:bp
353:bp
265:bp
252:bp
160:;
156::
152:;
148::
144:;
140::
136:;
132::
85:,
81:,
77:,
1851:e
1844:t
1837:v
1826:.
1712:e
1705:t
1698:v
1683:.
1669::
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284:)
181:)
164::
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