329:
306:
203:
228:
4342:
4312:
4327:
335:
234:
40:
587:
66:
580:
5444:
3747:
Marone M, Bonanno G, Rutella S, Leone G, Scambia G, Pierelli L (2002). "Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21".
3220:
Schönherr E, Broszat M, Brandan E, Bruckner P, Kresse H (July 1998). "Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen".
2593:
Vaughn SP, Broussard S, Hall CR, Scott A, Blanton SH, Milunsky JM, Hecht JT (May 2000). "Confirmation of the mapping of the
Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region".
3095:
Rodríguez LS, Narváez CF, Rojas OL, Franco MA, Ángel J (2012-01-01). "Human myeloid dendritic cells treated with supernatants of rotavirus infected Caco-2 cells induce a poor Th1 response".
3008:
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, Che F, Chen X, Ren H, Hong M, Wang J (March 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage".
5437:
342:
241:
5430:
3386:
Ebner R, Chen RH, Lawler S, Zioncheck T, Derynck R (November 1993). "Determination of type I receptor specificity by the type II receptors for TGF-beta or activin".
3339:"Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta"
4921:
4382:
4682:
4403:
2374:. Likewise, macrophages and monocytes respond to low levels of TGF-β1 in a chemotactic manner. Furthermore, the expression of monocytic cytokines (such as
2127:
2923:
Gilbert KM, Thoman M, Bauche K, Pham T, Weigle WO (1997). "Transforming growth factor-beta 1 induces antigen-specific unresponsiveness in naive T cells".
4341:
4311:
2366:) intermediates. However, as with other cell types, TGF-β1 can also have the opposite effect on cells of myeloid origin. For example, TGF-β1 acts as a
1860:
4326:
1841:
4819:
4813:
4808:
4798:
4793:
4788:
4783:
4778:
164:
4954:
2354:
are predominantly suppressive; this cytokine can inhibit the proliferation of these cells and prevent their production of reactive oxygen (e.g.
7002:
5179:
7060:
4291:
3709:
2526:
2508:
5380:
5375:
5370:
4635:
3663:
Yamada Y (2001). "Association of polymorphisms of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis".
4485:
3488:
McGonigle S, Beall MJ, Feeney EL, Pearce EJ (February 2001). "Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors".
328:
5362:
4727:
2544:
Ghadami M, Makita Y, Yoshida K, Nishimura G, Fukushima Y, Wakui K, Ikegawa S, Yamada K, Kondo S, Niikawa N, Tomita Ha (January 2000).
2060:
4982:
3930:
McGowan TA, Zhu Y, Sharma K (2004). "Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy".
3298:"The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response"
2884:"Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response"
2067:
3864:
Grainger DJ (2004). "Transforming growth factor beta and atherosclerosis: so far, so good for the protective cytokine hypothesis".
305:
4375:
2644:"Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization"
6921:
6347:
5991:
5687:
5542:
5268:
5197:
4867:
4590:
4425:
2495:
2474:
2242:, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or
5329:
4997:
4006:"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets"
3173:"Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta"
2833:
Wahl SM, Hunt DA, Wong HL, Dougherty S, McCartney-Francis N, Wahl LM, Ellingsworth L, Schmidt JA, Hall G, Roberts AB (1988).
227:
202:
2491:
2835:"Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation"
63:
6753:
6589:
6454:
6337:
6239:
6165:
5977:
5868:
5532:
4877:
4550:
4543:
4538:
4533:
4528:
3784:
Schnaper HW, Hayashida T, Hubchak SC, Poncelet AC (2003). "TGF-beta signal transduction and mesangial cell fibrogenesis".
2470:
1361:
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
6879:
6789:
6725:
6545:
6422:
6310:
6121:
5767:
5467:
5453:
5256:
5251:
4947:
4523:
4518:
4513:
4508:
4503:
4498:
3431:"Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis"
2306:
the expression of certain cytokines in T cells and promote their proliferation, particularly if the cells are immature.
144:
5385:
5147:
4368:
2414:
2379:
2291:
341:
240:
6721:
6541:
6418:
6117:
5763:
5656:
5517:
5241:
5224:
5189:
5026:
4829:
4493:
2168:
4084:"Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling"
334:
233:
6865:
5758:
5646:
4612:
4395:
4284:
2734:"Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells"
2685:"A comparative profile of total protein and six angiogenically-active growth factors in three platelet products"
5411:
4971:
4710:
4655:
4639:
2178:
1905:
152:
4158:
Redondo S, Santos-Gallego CG, Tejerina T (2007). "TGF-beta1: a novel target for cardiovascular pharmacology".
3429:
Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E (March 2000).
2684:
3132:"The Smad3 protein is involved in TGF-beta inhibition of class II transactivator and class II MHC expression"
7070:
5390:
5174:
4940:
1886:
2882:
Tiemessen MM, Kunzmann S, Schmidt-Weber CB, Garssen J, Bruijnzeel-Koomen CA, Knol EF, van Hoffen E (2003).
3634:
Reinhold D, Wrenger S, Kähne T, Ansorge S (1999). "HIV-1 Tat: immunosuppression via TGF-beta1 induction".
3171:
Hildebrand A, Romarís M, Rasmussen LM, Heinegård D, Twardzik DR, Border WA, Ruoslahti E (September 1994).
2732:
Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV (1985).
216:
2200:. Many cells synthesize TGF-β and almost all of them have specific receptors for this peptide. TGF-β1,
4277:
3442:
3395:
2745:
2319:
2143:
131:
7012:
5406:
4762:
4447:
2439:
6206:
5817:
5720:
6962:
6837:
5600:
5459:
4837:
4626:
4226:
3992:
3955:
3918:
3809:
3772:
3727:
3601:"The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins"
3513:
3033:
2990:
2864:
2769:
2271:
2174:
2139:
176:
6794:
6637:
6476:
6191:
2043:
2022:
1996:
1975:
6395:
6296:
6084:
6079:
6049:
6044:
5944:
4189:"Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update"
7065:
6987:
6064:
5527:
4857:
4417:
4246:
4218:
4175:
4146:
4113:
4070:
4035:
3984:
3947:
3910:
3881:
3852:
3801:
3764:
3715:
3705:
3680:
3651:
3622:
3587:
3552:
3505:
3470:
3411:
3368:
3319:
3278:
3237:
3202:
3153:
3112:
3077:
3025:
2982:
2940:
2905:
2856:
2815:
2761:
2714:
2665:
2610:
2575:
2259:
2224:
2152:
124:
56:
6286:
6211:
6034:
5934:
5822:
5725:
5575:
3967:
Sheppard D (2005). "Integrin-mediated activation of latent transforming growth factor beta".
7007:
6997:
6089:
6039:
5730:
5580:
4882:
4872:
4631:
4413:
4208:
4200:
4167:
4138:
4103:
4095:
4060:
4025:
4017:
3976:
3939:
3902:
3873:
3842:
3834:
3793:
3756:
3697:
3672:
3643:
3612:
3577:
3544:
3497:
3460:
3450:
3403:
3358:
3350:
3309:
3268:
3229:
3192:
3184:
3143:
3104:
3067:
3017:
2974:
2932:
2895:
2846:
2807:
2753:
2704:
2696:
2655:
2602:
2565:
2557:
2287:
2279:
2262:) release TGF-β1 to inhibit the actions of other T cells. Specifically, TGF-β1 prevents the
1661:
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
421:
352:
296:
251:
6390:
6201:
5812:
5715:
5710:
2134:. It is a secreted protein that performs many cellular functions, including the control of
172:
6818:
6748:
6743:
6661:
6584:
6579:
6449:
6444:
6267:
6160:
6155:
5915:
5802:
5797:
5682:
5308:
5303:
5161:
4862:
3739:
3566:"Latent transforming growth factor-beta: structural features and mechanisms of activation"
2367:
586:
396:
4360:
3446:
3399:
3257:"Bone matrix decorin binds transforming growth factor-beta and enhances its bioactivity"
2749:
1741:
transforming growth factor beta receptor signaling pathway involved in heart development
5422:
4766:
4391:
4213:
4188:
4108:
4083:
4030:
4021:
4005:
3877:
3197:
3172:
2709:
2570:
2545:
2398:
579:
39:
3847:
3822:
3647:
3501:
3273:
3256:
3072:
3055:
2660:
2643:
1775:
1770:
1765:
1760:
1755:
1750:
1745:
1740:
1735:
1730:
1725:
1720:
1715:
1710:
1705:
1700:
1695:
1690:
1685:
1680:
1675:
1670:
1665:
1660:
1655:
1650:
1645:
1640:
1635:
1630:
1625:
1620:
1615:
1610:
1605:
1600:
1595:
1590:
1585:
1580:
1575:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1535:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1125:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
135:, CED, DPD1, LAP, TGFB, TGFbeta, transforming growth factor beta 1, IBDIMDE, TGF-beta1
7054:
6972:
5565:
4963:
4255:
4230:
3676:
3465:
3430:
3363:
3338:
2978:
2811:
2546:"Genetic mapping of the Camurati-Engelmann disease locus to chromosome 19q13.1-q13.3"
2402:
2375:
2299:
2275:
2267:
2263:
2239:
2220:
2193:
2186:
615:
3959:
3922:
3813:
3776:
3517:
3037:
3021:
2994:
2868:
6992:
6375:
6370:
6059:
6019:
6014:
5590:
3996:
2773:
2433:
2383:
2363:
2335:
414:
193:
4171:
3535:
Border WA, Noble NA (1994). "Transforming growth factor beta in tissue fibrosis".
3108:
3056:"The role of TGF-beta in growth, differentiation, and maturation of B lymphocytes"
156:
3692:
Chen W, Wahl SM (2002). "TGF-β: Receptors, Signaling
Pathways and Autoimmunity".
2298:. It can also decrease the expression levels of cytokine receptors, such as the
1071:
negative regulation of transforming growth factor beta receptor signaling pathway
180:
6982:
6680:
6380:
6024:
4892:
4852:
3797:
3548:
2851:
2834:
2531:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2513:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2331:
2295:
2232:
2135:
3148:
3131:
1771:
positive regulation of production of miRNAs involved in gene silencing by miRNA
1296:
negative regulation of production of miRNAs involved in gene silencing by miRNA
497:
7022:
6933:
6929:
6715:
6535:
6359:
6355:
6054:
6003:
5999:
5862:
5699:
5695:
5640:
5554:
5550:
5506:
5212:
5207:
4748:
4440:
4435:
4142:
4099:
3980:
3943:
3906:
2936:
2355:
2347:
2228:
2216:
313:
210:
160:
4204:
3617:
3600:
3314:
3297:
1576:
connective tissue replacement involved in inflammatory response wound healing
6915:
6911:
6902:
6812:
6808:
6779:
6711:
6707:
6655:
6651:
6627:
6531:
6527:
6494:
6490:
6332:
6291:
6074:
5972:
5939:
5909:
5905:
5886:
5858:
5854:
5651:
5636:
5632:
5512:
5502:
5498:
5313:
5169:
4585:
4065:
4048:
3407:
2900:
2883:
2394:
2323:
2243:
2197:
2190:
2182:
2147:
1805:
557:
435:
380:
367:
279:
266:
168:
6888:
6319:
4222:
4179:
4150:
4117:
4074:
4039:
3988:
3951:
3914:
3885:
3856:
3805:
3768:
3760:
3719:
3684:
3655:
3626:
3509:
3474:
3455:
3372:
3233:
3157:
3116:
3081:
3029:
2986:
2909:
2718:
2614:
2606:
2579:
2205:
2201:
3591:
3556:
3415:
3354:
3323:
3282:
3241:
3206:
2944:
2860:
2819:
2765:
2669:
2282:. Similarly, TGF-β1 can inhibit the secretion and activity of many other
2181:, and other functions in many cell types. TGF-β acts synergistically with
2107:
2102:
7039:
5123:
3564:
Munger JS, Harpel JG, Gleizes PE, Mazzieri R, Nunes I, Rifkin DB (1997).
2628:
2371:
2351:
2327:
2302:
to down-regulate the activity of immune cells. However, TGF-β1 can also
2283:
2212:
2131:
2091:
1950:
1931:
3582:
3565:
1526:
regulation of transforming growth factor beta receptor signaling pathway
6977:
6967:
6907:
6804:
6703:
6647:
6523:
6486:
5901:
5850:
5628:
5494:
5298:
5237:
4847:
4842:
4260:
4250:
4187:
Ren H, Han R, Chen X, Liu X, Wan J, Wang L, Yang X, Wang J (May 2020).
2700:
2422:
1917:
1872:
1006:
positive regulation of branching involved in ureteric bud morphogenesis
3701:
3188:
1466:
positive regulation of pathway-restricted SMAD protein phosphorylation
1366:
negative regulation of release of sequestered calcium ion into cytosol
101:
97:
93:
89:
85:
7028:
6826:
6822:
6690:
6669:
6665:
6505:
6275:
6271:
6069:
5923:
5919:
4905:
4804:
4774:
4720:
4715:
4692:
4687:
4677:
4670:
4665:
3838:
3823:"Epithelial-mesenchymal transition and its implications for fibrosis"
2757:
2390:
2315:
2255:
2075:
1827:
17:
4126:
2962:
2795:
2733:
1591:
positive regulation of vascular endothelial growth factor production
1061:
regulation of branching involved in mammary gland duct morphogenesis
6104:
5745:
3696:. Current Directions in Autoimmunity. Vol. 5. pp. 62–91.
2561:
1641:
positive regulation of pri-miRNA transcription by RNA polymerase II
6957:
6889:
6847:
6784:
6632:
6621:
6617:
6573:
6569:
6565:
6438:
6406:
6405:
6341:
6320:
6257:
6251:
6185:
6149:
6145:
6141:
5985:
5981:
5959:
5891:
5880:
5791:
5787:
5676:
5672:
5521:
5352:
5347:
5342:
5337:
5293:
5288:
5283:
5278:
5142:
5137:
5132:
5108:
5102:
5096:
5090:
5070:
5066:
5057:
5053:
5044:
5040:
4900:
4732:
4660:
4605:
4600:
4595:
4474:
4467:
4462:
4457:
4350:: SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 18-33 OF 33 STRUCTURES
3893:
Attisano L, Labbé E (2004). "TGFbeta and Wnt pathway cross-talk".
2445:
2428:
796:
positive regulation of transcription regulatory region DNA binding
4932:
4320:: SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 1-17 OF 33 STRUCTURES
1790:
1786:
6773:
6769:
6765:
6761:
6757:
6737:
6733:
6729:
6613:
6609:
6605:
6601:
6597:
6593:
6561:
6557:
6553:
6549:
6470:
6466:
6462:
6458:
6434:
6430:
6426:
6247:
6243:
6221:
6181:
6177:
6173:
6169:
6137:
6133:
6129:
6125:
6099:
5954:
5876:
5872:
5832:
5783:
5779:
5775:
5771:
5740:
5668:
5664:
5660:
5610:
5536:
5476:
5062:
5049:
5036:
5014:
5010:
5006:
5001:
4993:
4580:
4575:
4570:
4565:
4560:
4555:
4452:
4335:: SOLUTION STRUCTURE OF TGF-B1, NMR, MINIMIZED AVERAGE STRUCTURE
2196:. Dysregulation of TGF-β activation and signaling may result in
2156:
148:
5426:
4936:
4364:
4273:
2642:
Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB (1983).
595:
6848:
4269:
1536:
negative regulation of protein localization to plasma membrane
1311:
positive regulation of NF-kappaB transcription factor activity
1026:
negative regulation of blood vessel endothelial cell migration
891:
positive regulation of blood vessel endothelial cell migration
2689:
GMS Interdisciplinary
Plastic and Reconstructive Surgery DGPW
2274:
in activated T cells, as well as the activation of quiescent
1531:
positive regulation of phosphatidylinositol 3-kinase activity
956:
cellular response to transforming growth factor beta stimulus
4245:
Overview of all the structural information available in the
1541:
positive regulation of NAD+ ADP-ribosyltransferase activity
1286:
positive regulation of epithelial to mesenchymal transition
2322:
state of the cell. It inhibits proliferation, stimulates
2235:
processed to produce a mature peptide of 112 amino acids.
2208:
all function through the same receptor signaling systems.
1766:
regulation of pri-miRNA transcription by RNA polymerase II
1436:
positive regulation of protein-containing complex assembly
1236:
branch elongation involved in mammary gland duct branching
1156:
positive regulation of cardiac muscle cell differentiation
926:
transforming growth factor beta receptor signaling pathway
2173:
TGF-β is a multifunctional set of peptides that controls
1626:
positive regulation of transcription by RNA polymerase II
1566:
positive regulation of smooth muscle cell differentiation
1561:
positive regulation of peptidyl-threonine phosphorylation
1556:
negative regulation of skeletal muscle tissue development
1276:
negative regulation of transcription by RNA polymerase II
684:
type III transforming growth factor beta receptor binding
3694:
TGF-beta: receptors, signaling pathways and autoimmunity
3130:
Dong Y, Tang L, Letterio JJ, Benveniste EN (July 2001).
2401:, which in turn decreases the activation of appropriate
1671:
cellular response to insulin-like growth factor stimulus
1571:
positive regulation of isotype switching to IgA isotypes
1456:
positive regulation of regulatory T cell differentiation
1146:
positive regulation of peptidyl-tyrosine phosphorylation
629:
type II transforming growth factor beta receptor binding
404:
6852:
5454:
2683:
Custo, S; Baron, B; Felice, A; Seria, E (5 July 2022).
2629:"Entrez Gene: TGFB1 transforming growth factor, beta 1"
1636:
positive regulation of SMAD protein signal transduction
1041:
negative regulation of extracellular matrix disassembly
659:
type I transforming growth factor beta receptor binding
6222:
6100:
5955:
5833:
5741:
5611:
5481:
5477:
4049:"Escaping from the TGFbeta anti-proliferative control"
1401:
positive regulation of protein localization to nucleus
1091:
positive regulation of peptidyl-serine phosphorylation
866:
negative regulation of hyaluronan biosynthetic process
4082:
Lee CG, Kang HR, Homer RJ, Chupp G, Elias JA (2006).
916:
negative regulation of macrophage cytokine production
569:
1651:
positive regulation of cell population proliferation
1261:
positive regulation of extracellular matrix assembly
1246:
positive regulation of epithelial cell proliferation
951:
positive regulation of collagen biosynthetic process
936:
negative regulation of cell population proliferation
896:
negative regulation of epithelial cell proliferation
6947:
6887:
6878:
6846:
6689:
6504:
6404:
6318:
6309:
6220:
6098:
5953:
5831:
5739:
5609:
5475:
5466:
5399:
5361:
5328:
5265:
5234:
5223:
5188:
5160:
5118:
5079:
5023:
4979:
4970:
4914:
4891:
4828:
4761:
4741:
4703:
4648:
4625:
4483:
4411:
4402:
4127:"Transforming growth factor-beta: innately bipolar"
2036:
2015:
1989:
1968:
1381:
negative regulation of transcription, DNA-templated
1106:
positive regulation of transcription, DNA-templated
6226:
5837:
5615:
2487:
2485:
2483:
2466:
2464:
2462:
2238:TGF-β1 plays an important role in controlling the
1596:positive regulation of superoxide anion generation
1151:positive regulation of protein import into nucleus
1016:epidermal growth factor receptor signaling pathway
669:protein serine/threonine kinase activator activity
2963:"TGF-beta: a mobile purveyor of immune privilege"
1721:membrane protein intracellular domain proteolysis
1666:positive regulation of mononuclear cell migration
996:positive regulation of protein kinase B signaling
351:
250:
6691:
6506:
1211:regulation of striated muscle tissue development
1176:negative regulation of interleukin-17 production
1166:positive regulation of interleukin-17 production
1031:positive regulation of protein dephosphorylation
981:positive regulation of protein metabolic process
689:transforming growth factor beta receptor binding
6510:
1731:ventricular cardiac muscle tissue morphogenesis
1486:regulation of regulatory T cell differentiation
1351:phosphate-containing compound metabolic process
1101:negative regulation of neuroblast proliferation
1051:positive regulation of fibroblast proliferation
991:negative regulation of myoblast differentiation
976:negative regulation of fat cell differentiation
971:regulation of actin cytoskeleton reorganization
961:pathway-restricted SMAD protein phosphorylation
27:Protein-coding gene in the species Homo sapiens
3255:Takeuchi Y, Kodama Y, Matsumoto T (Dec 1994).
2492:GRCm38: Ensembl release 89: ENSMUSG00000002603
1451:negative regulation of gene silencing by miRNA
1196:negative regulation of protein phosphorylation
1086:regulation of SMAD protein signal transduction
811:positive regulation of protein phosphorylation
5438:
4948:
4376:
4285:
1471:mammary gland branching involved in thelarche
1396:lipopolysaccharide-mediated signaling pathway
1326:hematopoietic progenitor cell differentiation
8:
2796:"Regulation of immune responses by TGF-beta"
2326:of B cells, and controls the expression of
1736:positive regulation of ERK1 and ERK2 cascade
1256:cellular response to organic cyclic compound
1021:macrophage derived foam cell differentiation
881:positive regulation of vascular permeability
791:positive regulation of histone deacetylation
4259:(Transforming growth factor beta-1) at the
2471:GRCh38: Ensembl release 89: ENSG00000105329
2128:transforming growth factor beta superfamily
1611:positive regulation of fibroblast migration
1551:regulation of cell population proliferation
1461:cellular response to growth factor stimulus
1291:cellular response to dexamethasone stimulus
1116:negative regulation of T cell proliferation
1056:negative regulation of cell differentiation
1001:common-partner SMAD protein phosphorylation
6884:
6315:
5472:
5445:
5431:
5423:
5231:
4976:
4955:
4941:
4933:
4645:
4408:
4383:
4369:
4361:
4292:
4278:
4270:
2386:can be increased by the action of TGF-β1.
2370:, directing an immune response to certain
1801:
1521:positive regulation of histone acetylation
1241:positive regulation of bone mineralization
941:positive regulation of receptor clustering
826:positive regulation of MAP kinase activity
611:
392:
291:
188:
74:
4212:
4107:
4064:
4029:
3846:
3616:
3581:
3464:
3454:
3362:
3313:
3272:
3196:
3147:
3071:
3049:
3047:
2899:
2850:
2789:
2787:
2785:
2783:
2708:
2659:
2569:
2338:proteins on immature and mature B cells.
2215:as a protein with a molecular mass of 25
1776:regulation of signaling receptor activity
1631:negative regulation of mitotic cell cycle
1446:negative regulation of cell-cell adhesion
1141:regulation of protein import into nucleus
3337:Saharinen J, Keski-Oja J (August 2000).
2223:. It was later characterized as a large
1686:cellular response to mechanical stimulus
1586:positive regulation of apoptotic process
1581:ossification involved in bone remodeling
1386:negative regulation of T cell activation
1336:positive regulation of protein secretion
1066:positive regulation of exit from mitosis
4307:
2961:Wahl SM, Wen J, Moutsopoulos N (2006).
2956:
2954:
2458:
2150:. In humans, TGF-β1 is encoded by the
1691:cellular response to ionizing radiation
1331:regulation of interleukin-23 production
1046:mitotic cell cycle checkpoint signaling
3735:
3725:
1646:positive regulation of gene expression
1546:negative regulation of immune response
1501:myeloid dendritic cell differentiation
1496:negative regulation of DNA replication
1476:response to laminar fluid shear stress
1081:morphogenesis of a branching structure
1076:negative regulation of gene expression
29:
2211:TGF-β1 was first identified in human
1676:positive regulation of cell migration
1201:regulation of blood vessel remodeling
1036:extrinsic apoptotic signaling pathway
356:
317:
312:
255:
214:
209:
7:
1616:positive regulation of cell division
1391:positive regulation of odontogenesis
1346:epithelial to mesenchymal transition
1301:mitigation of host defenses by virus
4004:Gressner AM, Weiskirchen R (2006).
3296:Choy L, Derynck R (November 1998).
2389:TGF-β1 reduces the efficacy of the
1431:response to organic cyclic compound
1426:negative regulation of phagocytosis
1231:regulation of cartilage development
861:negative regulation of ossification
806:tolerance induction to self antigen
679:protein heterodimerization activity
6955:Endogenous antagonists/inhibitors:
4022:10.1111/j.1582-4934.2006.tb00292.x
3878:10.1161/01.ATV.0000114567.76772.33
2033:
2012:
1986:
1965:
1941:
1922:
1896:
1877:
1851:
1832:
1126:negative regulation of cell growth
831:regulation of sodium ion transport
574:
492:
430:
409:
25:
2120:Transforming growth factor beta 1
1681:response to immobilization stress
1226:regulatory T cell differentiation
1131:positive regulation of chemotaxis
841:negative regulation of cell cycle
664:protein homodimerization activity
4340:
4325:
4310:
3866:Arterioscler. Thromb. Vasc. Biol
3677:10.1097/00008571-200112000-00004
2979:10.1111/j.1600-065X.2006.00437.x
2812:10.1146/annurev.immunol.16.1.137
2794:Letterio JJ, Roberts AB (1998).
2318:that also vary according to the
2183:transforming growth factor-alpha
1266:cellular calcium ion homeostasis
1011:SMAD protein signal transduction
585:
578:
340:
333:
327:
304:
239:
232:
226:
201:
38:
5269:Relaxin family peptide hormones
4404:TGF beta superfamily of ligands
3054:Lebman DA, Edmiston JS (1999).
3022:10.1016/j.pneurobio.2019.03.003
2126:is a polypeptide member of the
1306:lens fiber cell differentiation
986:cell-cell junction organization
946:regulation of apoptotic process
5731:ML-347 (LDN-193719, VU0469381)
5581:ML-347 (LDN-193719, VU0469381)
4551:Growth differentiation factors
3821:Kalluri R, Neilson EG (2003).
2314:TGF-β1 has similar effects on
1376:mononuclear cell proliferation
596:More reference expression data
558:More reference expression data
1:
4172:10.1016/j.cytogfr.2007.04.005
3786:Am. J. Physiol. Renal Physiol
3648:10.1016/S0167-5699(99)01497-8
3502:10.1016/s0014-5793(01)02133-0
3274:10.1016/S0021-9258(18)31681-8
3109:10.1016/j.cellimm.2011.10.017
3073:10.1016/S1286-4579(99)00254-3
2661:10.1016/S0021-9258(18)32345-7
2413:TGF beta 1 has been shown to
2189:. It also acts as a negative
1356:regulation of gene expression
1316:extracellular matrix assembly
1206:SMAD protein complex assembly
921:cell population proliferation
846:response to organic substance
325:
224:
7061:Genes on human chromosome 19
3435:Proc. Natl. Acad. Sci. U.S.A
1506:salivary gland morphogenesis
1421:hyaluronan catabolic process
1411:regulation of cell migration
1341:frontal suture morphogenesis
765:platelet alpha granule lumen
6070:RepSox (E-616452, SJN-2511)
4494:Bone morphogenetic proteins
3798:10.1152/ajprenal.00300.2002
3549:10.1056/NEJM199411103311907
2852:10.4049/jimmunol.140.9.3026
2292:tumor necrosis factor-alpha
1746:embryonic liver development
1601:digestive tract development
1221:chondrocyte differentiation
1161:oligodendrocyte development
1136:protein export from nucleus
454:stromal cell of endometrium
7087:
5242:Insulin-like growth factor
4160:Cytokine Growth Factor Rev
3149:10.4049/jimmunol.167.1.311
2169:TGF beta signaling pathway
2166:
1511:receptor catabolic process
1441:protein kinase B signaling
634:protein N-terminus binding
6060:Galunisertib (LY-2157299)
4305:
4143:10.1016/j.coi.2006.11.008
4100:10.1513/pats.200602-017AW
3981:10.1007/s10555-005-5131-6
3944:10.1007/s11892-004-0055-z
2937:10.3109/08820139709022702
2527:"Mouse PubMed Reference:"
2509:"Human PubMed Reference:"
2346:The effects of TGF-β1 on
2219:with a potential role in
2106:
2101:
2097:
2090:
2074:
2055:
2040:
2019:
2008:
1993:
1972:
1961:
1948:
1944:
1929:
1925:
1916:
1903:
1899:
1884:
1880:
1871:
1858:
1854:
1839:
1835:
1826:
1811:
1804:
1800:
1784:
1706:heart valve morphogenesis
966:regulation of DNA binding
886:animal organ regeneration
851:mammary gland development
694:identical protein binding
614:
610:
593:
577:
568:
555:
504:
495:
462:Descending thoracic aorta
442:
433:
403:
395:
391:
374:
361:
324:
303:
294:
290:
273:
260:
223:
200:
191:
187:
142:
139:
129:
122:
117:
82:
77:
60:
55:
50:
46:
37:
32:
7008:Thrombospondin 1 (THBS1)
6790:Osteogenin (BMP3, BMP3A)
4711:Activin type 2 receptors
4656:Activin type 1 receptors
4205:10.1177/0271678X20923551
4193:J Cereb Blood Flow Metab
3618:10.1074/jbc.274.27.18843
3315:10.1074/jbc.273.47.31455
1321:ATP biosynthetic process
836:response to progesterone
801:ureteric bud development
5082:FGF homologous factors:
3907:10.1023/A:1025811012690
3408:10.1126/science.8235612
2061:Chr 19: 41.3 – 41.35 Mb
1716:neural tube development
1191:Notch signaling pathway
871:protein phosphorylation
821:response to cholesterol
6207:Dorsomorphin (BML-275)
5818:Dorsomorphin (BML-275)
5721:Dorsomorphin (BML-275)
4613:Anti-müllerian hormone
4396:TGFβ signaling pathway
3761:10.1080/10428190210195
3456:10.1073/pnas.97.6.2626
3234:10.1006/abbi.1998.0720
3222:Arch. Biochem. Biophys
2607:10.1006/geno.2000.6192
2068:Chr 7: 25.39 – 25.4 Mb
1491:platelet degranulation
1181:lymph node development
876:T cell differentiation
649:growth factor activity
528:mesenteric lymph nodes
4066:10.1093/carcin/bgl068
3969:Cancer Metastasis Rev
3895:Cancer Metastasis Rev
3355:10.1091/mbc.11.8.2691
3136:Journal of Immunology
2901:10.1093/intimm/dxg147
2362:) and nitrogen (e.g.
2294:(TNF-α), and various
1751:BMP signaling pathway
1406:response to estradiol
1371:response to radiation
1216:response to vitamin D
1171:inflammatory response
906:inner ear development
901:regulation of binding
516:stroma of bone marrow
466:right coronary artery
217:Chromosome 19 (human)
5457:receptor superfamily
5363:Vascular endothelial
2382:), and macrophage's
2185:(TGF-α) in inducing
2144:cell differentiation
1121:response to wounding
816:endoderm development
770:extracellular matrix
715:extracellular region
358:7 A3|7 13.98 cM
319:Chromosome 7 (mouse)
78:List of PDB id codes
51:Available structures
7025:(against myostatin)
4448:Activin and inhibin
4131:Curr. Opin. Immunol
3583:10.1038/ki.1997.188
3447:2000PNAS...97.2626O
3400:1993Sci...262..900E
3097:Cellular Immunology
2750:1985Natur.316..701D
2440:TGF beta receptor 1
1726:leukocyte migration
1701:neural tube closure
1621:germ cell migration
1416:response to hypoxia
1281:response to glucose
775:extracellular space
735:blood microparticle
478:canal of the cervix
7031:(against endoglin)
6388:Kinase inhibitors:
6284:Kinase inhibitors:
6199:Kinase inhibitors:
6032:Kinase inhibitors:
5932:Kinase inhibitors:
5810:Kinase inhibitors:
5708:Kinase inhibitors:
5573:Kinase inhibitors:
4627:TGF beta receptors
4088:Proc Am Thorac Soc
2800:Annu. Rev. Immunol
2701:10.3205/iprs000167
2260:regulatory T cells
2246:) secrete TGF-β1.
2140:cell proliferation
1906:ENSMUSG00000002603
1656:liver regeneration
931:face morphogenesis
856:T cell homeostasis
784:Biological process
755:neuronal cell body
703:Cellular component
622:Molecular function
512:tibiofemoral joint
7048:
7047:
6943:
6942:
6874:
6873:
6305:
6304:
5598:Other inhibitors:
5420:
5419:
5324:
5323:
5156:
5155:
4930:
4929:
4830:Ligand inhibitors
4757:
4756:
4621:
4620:
4358:
4357:
4047:Seoane J (2006).
4010:J. Cell. Mol. Med
3711:978-3-8055-7308-5
3702:10.1159/000060548
3599:Iozzo RV (1999).
3189:10.1042/bj3020527
2550:Am. J. Hum. Genet
2376:interleukin(IL)-1
2364:nitric oxide (NO)
2280:cytotoxic T cells
2264:interleukin(IL)-1
2225:protein precursor
2117:
2116:
2113:
2112:
2086:
2085:
2051:
2050:
2030:
2029:
2004:
2003:
1983:
1982:
1957:
1956:
1938:
1937:
1912:
1911:
1893:
1892:
1867:
1866:
1848:
1847:
1796:
1795:
1761:apoptotic process
1711:heart development
1186:T cell activation
745:secretory granule
639:cytokine activity
606:
605:
602:
601:
564:
563:
551:
550:
489:
488:
387:
386:
286:
285:
181:TGFB1 - orthologs
113:
112:
109:
108:
61:Ortholog search:
16:(Redirected from
7078:
6891:
6885:
6854:
6850:
6835:Decoy receptors:
6780:Myostatin (GDF8)
6693:
6678:Decoy receptors:
6628:Myostatin (GDF8)
6512:
6508:
6408:
6322:
6316:
6228:
6224:
6106:
6102:
5961:
5957:
5887:Myostatin (GDF8)
5839:
5835:
5747:
5743:
5617:
5613:
5588:Decoy receptors:
5483:
5479:
5473:
5456:
5447:
5440:
5433:
5424:
5330:Platelet-derived
5272:
5245:
5232:
5126:
5084:
5030:
4987:
4977:
4957:
4950:
4943:
4934:
4646:
4409:
4385:
4378:
4371:
4362:
4344:
4329:
4314:
4294:
4287:
4280:
4271:
4234:
4216:
4199:(9): 1752–1768.
4183:
4154:
4125:Wahl SM (2007).
4121:
4111:
4078:
4068:
4043:
4033:
4000:
3963:
3926:
3889:
3860:
3850:
3839:10.1172/JCI20530
3817:
3780:
3743:
3737:
3733:
3731:
3723:
3688:
3665:Pharmacogenetics
3659:
3630:
3620:
3595:
3585:
3560:
3522:
3521:
3485:
3479:
3478:
3468:
3458:
3426:
3420:
3419:
3383:
3377:
3376:
3366:
3334:
3328:
3327:
3317:
3308:(47): 31455–62.
3293:
3287:
3286:
3276:
3252:
3246:
3245:
3217:
3211:
3210:
3200:
3168:
3162:
3161:
3151:
3127:
3121:
3120:
3092:
3086:
3085:
3075:
3066:(15): 1297–304.
3051:
3042:
3041:
3005:
2999:
2998:
2958:
2949:
2948:
2920:
2914:
2913:
2903:
2894:(12): 1495–504.
2879:
2873:
2872:
2854:
2830:
2824:
2823:
2791:
2778:
2777:
2758:10.1038/316701a0
2729:
2723:
2722:
2712:
2695:(Doc06): Doc06.
2680:
2674:
2673:
2663:
2639:
2633:
2632:
2625:
2619:
2618:
2590:
2584:
2583:
2573:
2541:
2535:
2534:
2523:
2517:
2516:
2505:
2499:
2489:
2478:
2468:
2227:(containing 390
2099:
2098:
2070:
2063:
2046:
2034:
2025:
2013:
2009:RefSeq (protein)
1999:
1987:
1978:
1966:
1942:
1923:
1897:
1878:
1852:
1833:
1802:
1756:cell development
1251:female pregnancy
612:
598:
589:
582:
575:
560:
500:
498:Top expressed in
493:
438:
436:Top expressed in
431:
410:
393:
383:
370:
359:
344:
337:
331:
320:
308:
292:
282:
269:
258:
243:
236:
230:
219:
205:
189:
183:
134:
127:
104:
75:
69:
48:
47:
42:
30:
21:
7086:
7085:
7081:
7080:
7079:
7077:
7076:
7075:
7051:
7050:
7049:
7044:
6963:Cerberus (CER1)
6939:
6870:
6842:
6749:Eptotermin alfa
6744:Dibotermin alfa
6685:
6585:Eptotermin alfa
6580:Dibotermin alfa
6500:
6450:Eptotermin alfa
6445:Dibotermin alfa
6400:
6301:
6216:
6161:Eptotermin alfa
6156:Dibotermin alfa
6094:
5949:
5827:
5803:Eptotermin alfa
5798:Dibotermin alfa
5735:
5683:Eptotermin alfa
5605:
5462:
5451:
5421:
5416:
5395:
5357:
5320:
5266:
5261:
5235:
5226:
5219:
5184:
5162:EGF-like domain
5152:
5119:
5114:
5080:
5075:
5024:
5019:
4980:
4966:
4961:
4931:
4926:
4910:
4887:
4824:
4753:
4737:
4699:
4629:
4617:
4479:
4426:TGF beta family
4398:
4389:
4359:
4354:
4351:
4345:
4336:
4330:
4321:
4315:
4301:
4298:
4267:
4242:
4237:
4186:
4166:(3–4): 279–86.
4157:
4124:
4081:
4059:(11): 2148–56.
4046:
4003:
3966:
3932:Curr. Diab. Rep
3929:
3892:
3863:
3833:(12): 1776–84.
3827:J. Clin. Invest
3820:
3783:
3746:
3734:
3724:
3712:
3691:
3662:
3633:
3611:(27): 18843–6.
3598:
3563:
3543:(19): 1286–92.
3537:N. Engl. J. Med
3534:
3530:
3528:Further reading
3525:
3487:
3486:
3482:
3428:
3427:
3423:
3394:(5135): 900–2.
3385:
3384:
3380:
3349:(8): 2691–704.
3343:Mol. Biol. Cell
3336:
3335:
3331:
3295:
3294:
3290:
3267:(51): 32634–8.
3254:
3253:
3249:
3219:
3218:
3214:
3170:
3169:
3165:
3129:
3128:
3124:
3094:
3093:
3089:
3060:Microbes Infect
3053:
3052:
3045:
3010:Prog. Neurobiol
3007:
3006:
3002:
2960:
2959:
2952:
2925:Immunol. Invest
2922:
2921:
2917:
2881:
2880:
2876:
2832:
2831:
2827:
2793:
2792:
2781:
2744:(6030): 701–5.
2731:
2730:
2726:
2682:
2681:
2677:
2654:(11): 7155–60.
2641:
2640:
2636:
2627:
2626:
2622:
2592:
2591:
2587:
2543:
2542:
2538:
2525:
2524:
2520:
2507:
2506:
2502:
2490:
2481:
2469:
2460:
2456:
2451:
2411:
2399:dendritic cells
2368:chemoattractant
2359:
2344:
2320:differentiation
2312:
2252:
2233:proteolytically
2179:differentiation
2171:
2165:
2108:View/Edit Mouse
2103:View/Edit Human
2066:
2059:
2056:Location (UCSC)
2042:
2021:
1995:
1974:
1887:ENSG00000105329
1780:
1096:cell activation
779:
740:plasma membrane
698:
674:protein binding
654:antigen binding
594:
584:
583:
556:
547:
542:
538:
534:
530:
526:
522:
518:
514:
510:
496:
485:
480:
476:
472:
468:
464:
460:
458:ascending aorta
456:
452:
448:
434:
378:
365:
357:
347:
346:
345:
338:
318:
295:Gene location (
277:
264:
256:
246:
245:
244:
237:
215:
192:Gene location (
143:
130:
123:
84:
62:
28:
23:
22:
15:
12:
11:
5:
7084:
7082:
7074:
7073:
7068:
7063:
7053:
7052:
7046:
7045:
7043:
7042:
7033:
7032:
7026:
7016:
7015:
7010:
7005:
7000:
6995:
6990:
6985:
6980:
6975:
6970:
6965:
6960:
6951:
6949:
6945:
6944:
6941:
6940:
6938:
6937:
6919:
6905:
6896:
6894:
6882:
6876:
6875:
6872:
6871:
6869:
6868:
6859:
6857:
6844:
6843:
6841:
6840:
6831:
6830:
6816:
6798:
6797:
6792:
6787:
6782:
6777:
6751:
6746:
6741:
6719:
6697:
6695:
6687:
6686:
6684:
6683:
6674:
6673:
6659:
6641:
6640:
6635:
6630:
6625:
6587:
6582:
6577:
6539:
6517:
6515:
6502:
6501:
6499:
6498:
6480:
6479:
6474:
6452:
6447:
6442:
6412:
6410:
6402:
6401:
6399:
6398:
6393:
6384:
6383:
6378:
6373:
6364:
6363:
6345:
6335:
6326:
6324:
6313:
6307:
6306:
6303:
6302:
6300:
6299:
6294:
6289:
6280:
6279:
6261:
6260:
6255:
6233:
6231:
6218:
6217:
6215:
6214:
6209:
6204:
6195:
6194:
6189:
6163:
6158:
6153:
6111:
6109:
6096:
6095:
6093:
6092:
6087:
6082:
6077:
6072:
6067:
6062:
6057:
6052:
6047:
6042:
6037:
6028:
6027:
6022:
6017:
6008:
6007:
5989:
5975:
5966:
5964:
5951:
5950:
5948:
5947:
5942:
5937:
5928:
5927:
5913:
5895:
5894:
5889:
5884:
5866:
5844:
5842:
5829:
5828:
5826:
5825:
5820:
5815:
5806:
5805:
5800:
5795:
5761:
5752:
5750:
5737:
5736:
5734:
5733:
5728:
5723:
5718:
5713:
5704:
5703:
5685:
5680:
5654:
5649:
5644:
5622:
5620:
5607:
5606:
5604:
5603:
5594:
5593:
5584:
5583:
5578:
5569:
5568:
5559:
5558:
5540:
5530:
5525:
5515:
5510:
5488:
5486:
5470:
5464:
5463:
5452:
5450:
5449:
5442:
5435:
5427:
5418:
5417:
5415:
5414:
5409:
5403:
5401:
5397:
5396:
5394:
5393:
5388:
5383:
5378:
5373:
5367:
5365:
5359:
5358:
5356:
5355:
5350:
5345:
5340:
5334:
5332:
5326:
5325:
5322:
5321:
5319:
5318:
5317:
5316:
5311:
5306:
5296:
5291:
5286:
5281:
5275:
5273:
5263:
5262:
5260:
5259:
5254:
5248:
5246:
5229:
5227:Relaxin family
5221:
5220:
5218:
5217:
5216:
5215:
5210:
5205:
5194:
5192:
5186:
5185:
5183:
5182:
5177:
5172:
5166:
5164:
5158:
5157:
5154:
5153:
5151:
5150:
5145:
5140:
5135:
5129:
5127:
5116:
5115:
5113:
5112:
5106:
5100:
5094:
5087:
5085:
5077:
5076:
5074:
5073:
5060:
5047:
5033:
5031:
5021:
5020:
5018:
5017:
5004:
4990:
4988:
4974:
4968:
4967:
4964:Growth factors
4962:
4960:
4959:
4952:
4945:
4937:
4928:
4927:
4925:
4924:
4918:
4916:
4912:
4911:
4909:
4908:
4903:
4897:
4895:
4889:
4888:
4886:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4834:
4832:
4826:
4825:
4823:
4822:
4817:
4811:
4802:
4796:
4791:
4786:
4781:
4771:
4769:
4759:
4758:
4755:
4754:
4752:
4751:
4745:
4743:
4739:
4738:
4736:
4735:
4730:
4725:
4724:
4723:
4718:
4707:
4705:
4701:
4700:
4698:
4697:
4696:
4695:
4690:
4680:
4675:
4674:
4673:
4668:
4663:
4652:
4650:
4643:
4623:
4622:
4619:
4618:
4616:
4615:
4610:
4609:
4608:
4603:
4598:
4593:
4588:
4586:Myostatin/GDF8
4583:
4578:
4573:
4568:
4563:
4558:
4548:
4547:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4506:
4501:
4490:
4488:
4481:
4480:
4478:
4477:
4472:
4471:
4470:
4465:
4460:
4455:
4445:
4444:
4443:
4438:
4433:
4422:
4420:
4406:
4400:
4399:
4392:Cell signaling
4390:
4388:
4387:
4380:
4373:
4365:
4356:
4355:
4353:
4352:
4346:
4339:
4337:
4331:
4324:
4322:
4316:
4309:
4306:
4303:
4302:
4299:
4297:
4296:
4289:
4282:
4274:
4265:
4264:
4241:
4240:External links
4238:
4236:
4235:
4184:
4155:
4122:
4079:
4053:Carcinogenesis
4044:
4001:
3975:(3): 395–402.
3964:
3927:
3901:(1–2): 53–61.
3890:
3872:(3): 399–404.
3861:
3818:
3792:(2): F243–52.
3781:
3749:Leuk. Lymphoma
3744:
3736:|journal=
3710:
3689:
3660:
3636:Immunol. Today
3631:
3596:
3576:(5): 1376–82.
3561:
3531:
3529:
3526:
3524:
3523:
3480:
3441:(6): 2626–31.
3421:
3378:
3329:
3288:
3247:
3212:
3163:
3122:
3087:
3043:
3000:
2950:
2915:
2874:
2845:(9): 3026–32.
2825:
2779:
2724:
2675:
2634:
2620:
2585:
2562:10.1086/302728
2536:
2518:
2500:
2479:
2457:
2455:
2452:
2450:
2449:
2443:
2437:
2431:
2426:
2419:
2410:
2407:
2378:α, IL-1β, and
2357:
2343:
2340:
2311:
2308:
2276:helper T cells
2251:
2248:
2187:transformation
2164:
2161:
2115:
2114:
2111:
2110:
2105:
2095:
2094:
2088:
2087:
2084:
2083:
2081:
2079:
2072:
2071:
2064:
2057:
2053:
2052:
2049:
2048:
2038:
2037:
2031:
2028:
2027:
2017:
2016:
2010:
2006:
2005:
2002:
2001:
1991:
1990:
1984:
1981:
1980:
1970:
1969:
1963:
1959:
1958:
1955:
1954:
1946:
1945:
1939:
1936:
1935:
1927:
1926:
1920:
1914:
1913:
1910:
1909:
1901:
1900:
1894:
1891:
1890:
1882:
1881:
1875:
1869:
1868:
1865:
1864:
1856:
1855:
1849:
1846:
1845:
1837:
1836:
1830:
1824:
1823:
1818:
1813:
1809:
1808:
1798:
1797:
1794:
1793:
1782:
1781:
1779:
1778:
1773:
1768:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1723:
1718:
1713:
1708:
1703:
1698:
1696:vasculogenesis
1693:
1688:
1683:
1678:
1673:
1668:
1663:
1658:
1653:
1648:
1643:
1638:
1633:
1628:
1623:
1618:
1613:
1608:
1606:cell migration
1603:
1598:
1593:
1588:
1583:
1578:
1573:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1533:
1528:
1523:
1518:
1513:
1508:
1503:
1498:
1493:
1488:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1423:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1383:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
787:
785:
781:
780:
778:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
706:
704:
700:
699:
697:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
644:enzyme binding
641:
636:
631:
625:
623:
619:
618:
608:
607:
604:
603:
600:
599:
591:
590:
572:
566:
565:
562:
561:
553:
552:
549:
548:
546:
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
502:
501:
490:
487:
486:
484:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
440:
439:
427:
426:
418:
407:
401:
400:
397:RNA expression
389:
388:
385:
384:
376:
372:
371:
363:
360:
355:
349:
348:
339:
332:
326:
322:
321:
316:
310:
309:
301:
300:
288:
287:
284:
283:
275:
271:
270:
262:
259:
254:
248:
247:
238:
231:
225:
221:
220:
213:
207:
206:
198:
197:
185:
184:
141:
137:
136:
128:
120:
119:
115:
114:
111:
110:
107:
106:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7083:
7072:
7069:
7067:
7064:
7062:
7059:
7058:
7056:
7041:
7038:
7035:
7034:
7030:
7027:
7024:
7021:
7018:
7017:
7014:
7013:Tomoregulin 1
7011:
7009:
7006:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6988:Gremlin (Drm)
6986:
6984:
6981:
6979:
6976:
6974:
6971:
6969:
6966:
6964:
6961:
6959:
6956:
6953:
6952:
6950:
6946:
6935:
6931:
6927:
6923:
6920:
6917:
6913:
6909:
6906:
6904:
6901:
6898:
6897:
6895:
6893:
6886:
6883:
6881:
6877:
6867:
6864:
6861:
6860:
6858:
6856:
6845:
6839:
6836:
6833:
6832:
6828:
6824:
6820:
6817:
6814:
6810:
6806:
6803:
6800:
6799:
6796:
6793:
6791:
6788:
6786:
6783:
6781:
6778:
6775:
6771:
6767:
6763:
6759:
6755:
6752:
6750:
6747:
6745:
6742:
6739:
6735:
6731:
6727:
6723:
6720:
6717:
6713:
6709:
6705:
6702:
6699:
6698:
6696:
6694:
6688:
6682:
6679:
6676:
6675:
6671:
6667:
6663:
6660:
6657:
6653:
6649:
6646:
6643:
6642:
6639:
6636:
6634:
6631:
6629:
6626:
6623:
6619:
6615:
6611:
6607:
6603:
6599:
6595:
6591:
6588:
6586:
6583:
6581:
6578:
6575:
6571:
6567:
6563:
6559:
6555:
6551:
6547:
6543:
6540:
6537:
6533:
6529:
6525:
6522:
6519:
6518:
6516:
6514:
6503:
6496:
6492:
6488:
6485:
6482:
6481:
6478:
6475:
6472:
6468:
6464:
6460:
6456:
6453:
6451:
6448:
6446:
6443:
6440:
6436:
6432:
6428:
6424:
6420:
6417:
6414:
6413:
6411:
6409:
6403:
6397:
6394:
6392:
6389:
6386:
6385:
6382:
6379:
6377:
6374:
6372:
6369:
6366:
6365:
6361:
6357:
6353:
6349:
6346:
6343:
6339:
6336:
6334:
6331:
6328:
6327:
6325:
6323:
6317:
6314:
6312:
6308:
6298:
6295:
6293:
6290:
6288:
6285:
6282:
6281:
6277:
6273:
6269:
6266:
6263:
6262:
6259:
6256:
6253:
6249:
6245:
6241:
6238:
6235:
6234:
6232:
6230:
6219:
6213:
6210:
6208:
6205:
6203:
6200:
6197:
6196:
6193:
6190:
6187:
6183:
6179:
6175:
6171:
6167:
6164:
6162:
6159:
6157:
6154:
6151:
6147:
6143:
6139:
6135:
6131:
6127:
6123:
6119:
6116:
6113:
6112:
6110:
6108:
6097:
6091:
6088:
6086:
6083:
6081:
6078:
6076:
6073:
6071:
6068:
6066:
6063:
6061:
6058:
6056:
6053:
6051:
6048:
6046:
6043:
6041:
6038:
6036:
6033:
6030:
6029:
6026:
6023:
6021:
6018:
6016:
6013:
6010:
6009:
6005:
6001:
5997:
5993:
5990:
5987:
5983:
5979:
5976:
5974:
5971:
5968:
5967:
5965:
5963:
5952:
5946:
5943:
5941:
5938:
5936:
5933:
5930:
5929:
5925:
5921:
5917:
5914:
5911:
5907:
5903:
5900:
5897:
5896:
5893:
5890:
5888:
5885:
5882:
5878:
5874:
5870:
5867:
5864:
5860:
5856:
5852:
5849:
5846:
5845:
5843:
5841:
5830:
5824:
5821:
5819:
5816:
5814:
5811:
5808:
5807:
5804:
5801:
5799:
5796:
5793:
5789:
5785:
5781:
5777:
5773:
5769:
5765:
5762:
5760:
5757:
5754:
5753:
5751:
5749:
5738:
5732:
5729:
5727:
5724:
5722:
5719:
5717:
5714:
5712:
5709:
5706:
5705:
5701:
5697:
5693:
5689:
5686:
5684:
5681:
5678:
5674:
5670:
5666:
5662:
5658:
5655:
5653:
5650:
5648:
5645:
5642:
5638:
5634:
5630:
5627:
5624:
5623:
5621:
5619:
5608:
5602:
5599:
5596:
5595:
5592:
5589:
5586:
5585:
5582:
5579:
5577:
5574:
5571:
5570:
5567:
5566:Ascrinvacumab
5564:
5561:
5560:
5556:
5552:
5548:
5544:
5541:
5538:
5534:
5531:
5529:
5526:
5523:
5519:
5516:
5514:
5511:
5508:
5504:
5500:
5496:
5493:
5490:
5489:
5487:
5485:
5474:
5471:
5469:
5465:
5461:
5458:
5448:
5443:
5441:
5436:
5434:
5429:
5428:
5425:
5413:
5410:
5408:
5405:
5404:
5402:
5398:
5392:
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5372:
5369:
5368:
5366:
5364:
5360:
5354:
5351:
5349:
5346:
5344:
5341:
5339:
5336:
5335:
5333:
5331:
5327:
5315:
5312:
5310:
5307:
5305:
5302:
5301:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5280:
5277:
5276:
5274:
5271:
5270:
5264:
5258:
5255:
5253:
5250:
5249:
5247:
5244:
5243:
5239:
5233:
5230:
5228:
5222:
5214:
5211:
5209:
5206:
5204:
5201:
5200:
5199:
5196:
5195:
5193:
5191:
5187:
5181:
5178:
5176:
5173:
5171:
5168:
5167:
5165:
5163:
5159:
5149:
5146:
5144:
5141:
5139:
5136:
5134:
5131:
5130:
5128:
5125:
5122:
5121:hormone-like:
5117:
5110:
5107:
5104:
5101:
5098:
5095:
5092:
5089:
5088:
5086:
5083:
5078:
5072:
5068:
5064:
5061:
5059:
5055:
5051:
5048:
5046:
5042:
5038:
5035:
5034:
5032:
5029:
5028:
5022:
5016:
5012:
5008:
5005:
5003:
4999:
4995:
4992:
4991:
4989:
4986:
4984:
4978:
4975:
4973:
4969:
4965:
4958:
4953:
4951:
4946:
4944:
4939:
4938:
4935:
4923:
4920:
4919:
4917:
4913:
4907:
4904:
4902:
4899:
4898:
4896:
4894:
4890:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4835:
4833:
4831:
4827:
4821:
4818:
4815:
4812:
4810:
4806:
4803:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4776:
4773:
4772:
4770:
4768:
4764:
4760:
4750:
4747:
4746:
4744:
4740:
4734:
4731:
4729:
4726:
4722:
4719:
4717:
4714:
4713:
4712:
4709:
4708:
4706:
4702:
4694:
4691:
4689:
4686:
4685:
4684:
4681:
4679:
4676:
4672:
4669:
4667:
4664:
4662:
4659:
4658:
4657:
4654:
4653:
4651:
4647:
4644:
4641:
4637:
4633:
4628:
4624:
4614:
4611:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4553:
4552:
4549:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4505:
4502:
4500:
4497:
4496:
4495:
4492:
4491:
4489:
4487:
4482:
4476:
4473:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4450:
4449:
4446:
4442:
4439:
4437:
4434:
4432:
4429:
4428:
4427:
4424:
4423:
4421:
4419:
4415:
4410:
4407:
4405:
4401:
4397:
4393:
4386:
4381:
4379:
4374:
4372:
4367:
4366:
4363:
4349:
4343:
4338:
4334:
4328:
4323:
4319:
4313:
4308:
4304:
4295:
4290:
4288:
4283:
4281:
4276:
4275:
4272:
4268:
4262:
4258:
4257:
4252:
4248:
4244:
4243:
4239:
4232:
4228:
4224:
4220:
4215:
4210:
4206:
4202:
4198:
4194:
4190:
4185:
4181:
4177:
4173:
4169:
4165:
4161:
4156:
4152:
4148:
4144:
4140:
4136:
4132:
4128:
4123:
4119:
4115:
4110:
4105:
4101:
4097:
4094:(5): 418–23.
4093:
4089:
4085:
4080:
4076:
4072:
4067:
4062:
4058:
4054:
4050:
4045:
4041:
4037:
4032:
4027:
4023:
4019:
4015:
4011:
4007:
4002:
3998:
3994:
3990:
3986:
3982:
3978:
3974:
3970:
3965:
3961:
3957:
3953:
3949:
3945:
3941:
3938:(6): 447–54.
3937:
3933:
3928:
3924:
3920:
3916:
3912:
3908:
3904:
3900:
3896:
3891:
3887:
3883:
3879:
3875:
3871:
3867:
3862:
3858:
3854:
3849:
3844:
3840:
3836:
3832:
3828:
3824:
3819:
3815:
3811:
3807:
3803:
3799:
3795:
3791:
3787:
3782:
3778:
3774:
3770:
3766:
3762:
3758:
3754:
3750:
3745:
3741:
3729:
3721:
3717:
3713:
3707:
3703:
3699:
3695:
3690:
3686:
3682:
3678:
3674:
3671:(9): 765–71.
3670:
3666:
3661:
3657:
3653:
3649:
3645:
3641:
3637:
3632:
3628:
3624:
3619:
3614:
3610:
3606:
3605:J. Biol. Chem
3602:
3597:
3593:
3589:
3584:
3579:
3575:
3571:
3567:
3562:
3558:
3554:
3550:
3546:
3542:
3538:
3533:
3532:
3527:
3519:
3515:
3511:
3507:
3503:
3499:
3496:(1–2): 65–9.
3495:
3491:
3484:
3481:
3476:
3472:
3467:
3462:
3457:
3452:
3448:
3444:
3440:
3436:
3432:
3425:
3422:
3417:
3413:
3409:
3405:
3401:
3397:
3393:
3389:
3382:
3379:
3374:
3370:
3365:
3360:
3356:
3352:
3348:
3344:
3340:
3333:
3330:
3325:
3321:
3316:
3311:
3307:
3303:
3302:J. Biol. Chem
3299:
3292:
3289:
3284:
3280:
3275:
3270:
3266:
3262:
3261:J. Biol. Chem
3258:
3251:
3248:
3243:
3239:
3235:
3231:
3227:
3223:
3216:
3213:
3208:
3204:
3199:
3194:
3190:
3186:
3183:(2): 527–34.
3182:
3178:
3174:
3167:
3164:
3159:
3155:
3150:
3145:
3141:
3137:
3133:
3126:
3123:
3118:
3114:
3110:
3106:
3103:(2): 154–61.
3102:
3098:
3091:
3088:
3083:
3079:
3074:
3069:
3065:
3061:
3057:
3050:
3048:
3044:
3039:
3035:
3031:
3027:
3023:
3019:
3015:
3011:
3004:
3001:
2996:
2992:
2988:
2984:
2980:
2976:
2972:
2968:
2964:
2957:
2955:
2951:
2946:
2942:
2938:
2934:
2931:(4): 459–72.
2930:
2926:
2919:
2916:
2911:
2907:
2902:
2897:
2893:
2889:
2885:
2878:
2875:
2870:
2866:
2862:
2858:
2853:
2848:
2844:
2840:
2836:
2829:
2826:
2821:
2817:
2813:
2809:
2805:
2801:
2797:
2790:
2788:
2786:
2784:
2780:
2775:
2771:
2767:
2763:
2759:
2755:
2751:
2747:
2743:
2739:
2735:
2728:
2725:
2720:
2716:
2711:
2706:
2702:
2698:
2694:
2690:
2686:
2679:
2676:
2671:
2667:
2662:
2657:
2653:
2649:
2648:J. Biol. Chem
2645:
2638:
2635:
2630:
2624:
2621:
2616:
2612:
2608:
2604:
2601:(1): 119–21.
2600:
2596:
2589:
2586:
2581:
2577:
2572:
2567:
2563:
2559:
2555:
2551:
2547:
2540:
2537:
2532:
2528:
2522:
2519:
2514:
2510:
2504:
2501:
2497:
2493:
2488:
2486:
2484:
2480:
2476:
2472:
2467:
2465:
2463:
2459:
2453:
2447:
2444:
2441:
2438:
2435:
2432:
2430:
2427:
2424:
2421:
2420:
2418:
2416:
2408:
2406:
2405:populations.
2404:
2403:helper T cell
2400:
2396:
2392:
2387:
2385:
2381:
2377:
2373:
2369:
2365:
2361:
2356:superoxide (O
2353:
2349:
2342:Myeloid cells
2341:
2339:
2337:
2333:
2329:
2325:
2321:
2317:
2309:
2307:
2305:
2301:
2300:IL-2 receptor
2297:
2293:
2289:
2285:
2281:
2277:
2273:
2272:proliferation
2269:
2268:interleukin-2
2265:
2261:
2257:
2249:
2247:
2245:
2241:
2240:immune system
2236:
2234:
2230:
2226:
2222:
2221:wound healing
2218:
2214:
2209:
2207:
2203:
2199:
2195:
2194:growth factor
2192:
2188:
2184:
2180:
2176:
2175:proliferation
2170:
2162:
2160:
2158:
2155:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2125:
2121:
2109:
2104:
2100:
2096:
2093:
2089:
2082:
2080:
2077:
2073:
2069:
2065:
2062:
2058:
2054:
2047:
2045:
2039:
2035:
2032:
2026:
2024:
2018:
2014:
2011:
2007:
2000:
1998:
1992:
1988:
1985:
1979:
1977:
1971:
1967:
1964:
1962:RefSeq (mRNA)
1960:
1953:
1952:
1947:
1943:
1940:
1934:
1933:
1928:
1924:
1921:
1919:
1915:
1908:
1907:
1902:
1898:
1895:
1889:
1888:
1883:
1879:
1876:
1874:
1870:
1863:
1862:
1857:
1853:
1850:
1844:
1843:
1838:
1834:
1831:
1829:
1825:
1822:
1819:
1817:
1814:
1810:
1807:
1803:
1799:
1792:
1788:
1783:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1687:
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1612:
1609:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1537:
1534:
1532:
1529:
1527:
1524:
1522:
1519:
1517:
1514:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1492:
1489:
1487:
1484:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1427:
1424:
1422:
1419:
1417:
1414:
1412:
1409:
1407:
1404:
1402:
1399:
1397:
1394:
1392:
1389:
1387:
1384:
1382:
1379:
1377:
1374:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1271:wound healing
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1182:
1179:
1177:
1174:
1172:
1169:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
788:
786:
783:
782:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
707:
705:
702:
701:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
626:
624:
621:
620:
617:
616:Gene ontology
613:
609:
597:
592:
588:
581:
576:
573:
571:
567:
559:
554:
544:body of femur
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
506:
503:
499:
494:
491:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
444:
441:
437:
432:
429:
428:
425:
423:
419:
417:
416:
412:
411:
408:
406:
402:
398:
394:
390:
382:
377:
373:
369:
364:
354:
350:
343:
336:
330:
323:
315:
311:
307:
302:
298:
293:
289:
281:
276:
272:
268:
263:
253:
249:
242:
235:
229:
222:
218:
212:
208:
204:
199:
195:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
138:
133:
126:
121:
116:
105:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
7036:
7019:
6954:
6925:
6899:
6862:
6834:
6802:Antagonists:
6801:
6700:
6677:
6645:Antagonists:
6644:
6520:
6484:Antagonists:
6483:
6415:
6387:
6376:Lerdelimumab
6371:Fresolimumab
6367:
6351:
6329:
6283:
6265:Antagonists:
6264:
6236:
6198:
6114:
6031:
6020:Lerdelimumab
6015:Fresolimumab
6011:
5995:
5969:
5931:
5899:Antagonists:
5898:
5847:
5809:
5755:
5707:
5691:
5625:
5597:
5591:Dalantercept
5587:
5572:
5562:
5546:
5491:
5267:
5236:
5225:Insulin/IGF/
5202:
5190:TGFβ pathway
5120:
5081:
5025:
4983:FGF receptor
4981:
4430:
4347:
4332:
4317:
4266:
4254:
4196:
4192:
4163:
4159:
4137:(1): 55–62.
4134:
4130:
4091:
4087:
4056:
4052:
4016:(1): 76–99.
4013:
4009:
3972:
3968:
3935:
3931:
3898:
3894:
3869:
3865:
3830:
3826:
3789:
3785:
3752:
3748:
3693:
3668:
3664:
3642:(8): 384–5.
3639:
3635:
3608:
3604:
3573:
3569:
3540:
3536:
3493:
3489:
3483:
3438:
3434:
3424:
3391:
3387:
3381:
3346:
3342:
3332:
3305:
3301:
3291:
3264:
3260:
3250:
3228:(2): 241–8.
3225:
3221:
3215:
3180:
3176:
3166:
3142:(1): 311–9.
3139:
3135:
3125:
3100:
3096:
3090:
3063:
3059:
3013:
3009:
3003:
2970:
2967:Immunol. Rev
2966:
2928:
2924:
2918:
2891:
2888:Int. Immunol
2887:
2877:
2842:
2838:
2828:
2803:
2799:
2741:
2737:
2727:
2692:
2688:
2678:
2651:
2647:
2637:
2623:
2598:
2594:
2588:
2556:(1): 143–7.
2553:
2549:
2539:
2530:
2521:
2512:
2503:
2412:
2409:Interactions
2388:
2345:
2336:MHC class II
2313:
2303:
2296:interleukins
2288:interferon-γ
2253:
2237:
2210:
2172:
2151:
2123:
2119:
2118:
2041:
2020:
1994:
1973:
1949:
1930:
1904:
1885:
1859:
1840:
1820:
1815:
1516:MAPK cascade
1481:human ageing
730:cell surface
420:
413:
140:External IDs
83:
7071:TGFβ domain
7020:Antibodies:
6983:Follistatin
6838:Ramatercept
6681:Sotatercept
6381:Metelimumab
6368:Antibodies:
6025:Metelimumab
6012:Antibodies:
5601:Disitertide
5563:Antibodies:
4893:Coreceptors
4853:Follistatin
4763:Transducers
4300:PDB gallery
3755:(1): 51–7.
2348:macrophages
2332:transferrin
2270:-dependent
2231:) that was
2229:amino acids
2217:kilodaltons
2136:cell growth
1111:cell growth
911:myelination
760:Golgi lumen
725:microvillus
520:granulocyte
446:granulocyte
379:25,404,502
366:25,386,427
278:41,353,922
265:41,301,587
118:Identifiers
7055:Categories
7023:Stamulumab
6973:DAN (PARN)
6892:(β-glycan)
6795:Radotermin
6638:Radotermin
6618:11 (BMP11)
6574:15 (GDF9B)
6477:Radotermin
6342:10 (BMP3B)
6252:11 (BMP11)
6192:Radotermin
6150:15 (GDF9B)
6055:LY-2109761
5986:11 (BMP11)
5982:10 (BMP3B)
5881:11 (BMP11)
5460:modulators
5412:Hepatocyte
4972:Fibroblast
4749:betaglycan
4484:Ligand of
4412:Ligand of
3570:Kidney Int
3177:Biochem. J
3016:: 101610.
2973:: 213–27.
2839:J. Immunol
2806:: 137–61.
2498:, May 2017
2477:, May 2017
2454:References
2395:astrocytes
2384:phagocytic
2286:including
2244:leukocytes
2167:See also:
474:right lung
424:(ortholog)
161:HomoloGene
6903:Avotermin
6866:AMH (MIS)
6863:Agonists:
6774:7 (BMP12)
6770:6 (BMP13)
6766:5 (BMP14)
6701:Agonists:
6610:7 (BMP12)
6606:6 (BMP13)
6602:5 (BMP14)
6521:Agonists:
6471:7 (BMP12)
6467:6 (BMP13)
6463:5 (BMP14)
6416:Agonists:
6396:LY-364947
6333:Avotermin
6330:Agonists:
6297:SB-505124
6292:SB-431542
6237:Agonists:
6178:7 (BMP12)
6174:6 (BMP13)
6170:5 (BMP14)
6115:Agonists:
6085:SB-525334
6080:SB-505124
6075:SB-431542
6050:LY-364947
6045:GW-788388
5973:Avotermin
5970:Agonists:
5945:SB-505124
5940:SB-431542
5848:Agonists:
5759:AMH (MIS)
5756:Agonists:
5652:Avotermin
5647:AMH (MIS)
5626:Agonists:
5513:Avotermin
5492:Agonists:
4231:218689863
3738:ignored (
3728:cite book
3490:FEBS Lett
2372:pathogens
2352:monocytes
2324:apoptosis
2284:cytokines
2213:platelets
2198:apoptosis
2191:autocrine
2148:apoptosis
2132:cytokines
2044:NP_035707
2023:NP_000651
1997:NM_011577
1976:NM_000660
1806:Orthologs
710:cytoplasm
536:lower jaw
169:GeneCards
7066:Proteins
7040:Endoglin
6948:Unsorted
6900:Ligands:
6880:Type III
6459:2 (BMP9)
6065:R-268712
5537:2 (BMP9)
5528:Cetermin
5124:FGF15/19
4985:ligands:
4838:Cerberus
4223:32423330
4180:17485238
4151:17137775
4118:16799085
4075:16698802
4040:16563223
3989:16258727
3960:45122439
3952:15539010
3923:41685620
3915:15000149
3886:14699019
3857:14679171
3814:17046094
3806:12529270
3777:28490341
3769:11908736
3720:11826761
3685:11740340
3656:10431160
3627:10383378
3518:84710903
3510:11172812
3475:10716993
3373:10930463
3158:11418665
3117:22082567
3082:10611758
3038:85495400
3030:30923023
2995:84309271
2987:16972906
2910:14645158
2869:35425214
2719:35909816
2615:10843814
2595:Genomics
2580:10631145
2494:–
2473:–
2415:interact
2328:antibody
2304:increase
2266:- &
2163:Function
2092:Wikidata
1785:Sources:
524:calvaria
450:monocyte
7037:Others:
6978:Decorin
6968:Chordin
6908:Inhibin
6805:Inhibin
6704:Activin
6648:Inhibin
6524:Activin
6487:Inhibin
6311:Type II
6287:A 83-01
6212:K-02288
6035:A 83-01
5935:A 83-01
5902:Inhibin
5851:Activin
5823:K-02288
5726:K-02288
5629:Activin
5576:K-02288
5495:Activin
5299:Relaxin
5238:Insulin
4858:Gremlin
4848:Decorin
4843:Chordin
4742:TGFBR3:
4704:TGFBR2:
4649:TGFBR1:
4632:Activin
4261:PDBe-KB
4251:UniProt
4214:7446569
4109:2658706
4031:3933103
3997:1929903
3592:9150447
3557:7935686
3443:Bibcode
3416:8235612
3396:Bibcode
3388:Science
3324:9813058
3283:7798269
3242:9675033
3207:8093006
3198:1137259
2945:9246566
2861:3129508
2820:9597127
2774:4245501
2766:3861940
2746:Bibcode
2710:9284722
2670:6602130
2571:1288319
2496:Ensembl
2475:Ensembl
2423:Decorin
2316:B cells
2310:B cells
2256:T cells
2250:T cells
1918:UniProt
1873:Ensembl
1812:Species
1791:QuickGO
720:nucleus
399:pattern
257:19q13.2
125:Aliases
7029:TRC105
6998:Noggin
6890:TGFβR3
6692:ACVR2B
6507:ACVR2A
6321:TGFβR2
6227:ACVR1C
6105:BMPR1B
6090:SD-208
6040:D-4476
5960:TGFβR1
5838:ACVR1B
5746:BMPR1A
5616:ACVR1A
5482:ACVRL1
5468:Type I
5386:VEGF-D
5381:VEGF-C
5376:VEGF-B
5371:VEGF-A
5180:HB-EGF
5111:(FHF4)
5105:(FHF2)
5099:(FHF1)
5093:(FHF3)
4906:Cripto
4873:Noggin
4805:I-SMAD
4775:R-SMAD
4721:ACVR2B
4716:ACVR2A
4693:BMPR1B
4688:BMPR1A
4678:ACVRL1
4671:ACVR1C
4666:ACVR1B
4640:family
4441:TGF-β3
4436:TGF-β2
4431:TGF-β1
4256:P01137
4229:
4221:
4211:
4178:
4149:
4116:
4106:
4073:
4038:
4028:
3995:
3987:
3958:
3950:
3921:
3913:
3884:
3855:
3848:297008
3845:
3812:
3804:
3775:
3767:
3718:
3708:
3683:
3654:
3625:
3590:
3555:
3516:
3508:
3473:
3463:
3414:
3371:
3361:
3322:
3281:
3240:
3205:
3195:
3156:
3115:
3080:
3036:
3028:
2993:
2985:
2943:
2908:
2867:
2859:
2818:
2772:
2764:
2738:Nature
2717:
2707:
2668:
2613:
2578:
2568:
2442:, and
2417:with:
2391:MHC II
2258:(e.g.
2206:TGF-β3
2204:, and
2202:TGF-β2
2146:, and
2124:TGF-β1
2078:search
2076:PubMed
1951:P04202
1932:P01137
1828:Entrez
570:BioGPS
540:thymus
532:spleen
470:spleen
149:190180
6993:LTBP1
6958:BAMBI
6849:AMHR2
6819:Lefty
6785:Nodal
6662:Lefty
6633:Nodal
6511:ACVR2
6407:BMPR2
6391:DMH-2
6268:Lefty
6258:Nodal
6202:DMH-2
5916:Lefty
5892:Nodal
5813:DMH-2
5716:DMH-2
5711:DMH-1
5407:Nerve
5400:Other
5353:PDGFD
5348:PDGFC
5343:PDGFB
5338:PDGFA
5294:INSL6
5289:INSL5
5284:INSL4
5279:INSL3
5213:TGFβ3
5208:TGFβ2
5203:TGFβ1
5148:FGF23
5143:FGF21
5138:FGF19
5133:FGF15
5109:FGF14
5103:FGF13
5097:FGF12
5091:FGF11
5071:FGF20
5067:FGF16
5058:FGF18
5054:FGF17
5045:FGF22
5041:FGF10
4915:Other
4901:BAMBI
4883:THBS1
4868:LTBP1
4863:Lefty
4820:SMAD4
4814:SMAD7
4809:SMAD6
4799:SMAD9
4794:SMAD5
4789:SMAD3
4784:SMAD2
4779:SMAD1
4733:BMPR2
4728:AMHR2
4683:BMPR1
4661:ACVR1
4606:GDF15
4601:GDF11
4596:GDF10
4544:BMP15
4539:BMP10
4534:BMP8b
4529:BMP8a
4475:Nodal
4468:INHBC
4463:INHBB
4458:INHBA
4418:TGFBR
4227:S2CID
3993:S2CID
3956:S2CID
3919:S2CID
3810:S2CID
3773:S2CID
3514:S2CID
3466:15979
3364:14949
3034:S2CID
2991:S2CID
2865:S2CID
2770:S2CID
2446:YWHAE
2434:LTBP1
2429:EIF3I
2380:TNF-α
2254:Some
2153:TGFB1
1861:21803
1821:Mouse
1816:Human
1787:Amigo
508:molar
482:blood
422:Mouse
415:Human
362:Start
297:Mouse
261:Start
194:Human
173:TGFB1
157:98725
132:TGFB1
33:TGFB1
18:TGFβ1
7003:TGIF
6922:TGFβ
6853:AMHR
6348:TGFβ
6223:ALK7
6101:ALK6
5992:TGFβ
5956:ALK5
5834:ALK4
5742:ALK3
5688:TGFβ
5612:ALK2
5543:TGFβ
5478:ALK1
5455:TGFβ
5257:IGF2
5252:IGF1
5240:and
5198:TGFβ
5170:TGFα
5063:FGF9
5050:FGF8
5037:FGF7
5015:FGF6
5011:FGF4
5007:FGF3
5002:FGF5
4998:FGF2
4994:FGF1
4922:SARA
4878:PARN
4767:SMAD
4591:GDF9
4581:GDF7
4576:GDF6
4571:GDF5
4566:GDF3
4561:GDF2
4556:GDF1
4524:BMP7
4519:BMP6
4514:BMP5
4509:BMP4
4504:BMP3
4499:BMP2
4486:BMPR
4453:INHA
4414:ACVR
4348:1kld
4333:1klc
4318:1kla
4249:for
4219:PMID
4176:PMID
4147:PMID
4114:PMID
4071:PMID
4036:PMID
3985:PMID
3948:PMID
3911:PMID
3882:PMID
3853:PMID
3802:PMID
3765:PMID
3740:help
3716:PMID
3706:ISBN
3681:PMID
3652:PMID
3623:PMID
3588:PMID
3553:PMID
3506:PMID
3471:PMID
3412:PMID
3369:PMID
3320:PMID
3279:PMID
3238:PMID
3203:PMID
3154:PMID
3113:PMID
3078:PMID
3026:PMID
2983:PMID
2941:PMID
2906:PMID
2857:PMID
2816:PMID
2762:PMID
2715:PMID
2666:PMID
2611:PMID
2576:PMID
2397:and
2350:and
2334:and
2278:and
2157:gene
1842:7040
750:axon
405:Bgee
353:Band
314:Chr.
252:Band
211:Chr.
145:OMIM
102:4KV5
98:3KFD
94:1KLD
90:1KLC
86:1KLA
67:RCSB
64:PDBe
6754:GDF
6722:BMP
6590:GDF
6542:BMP
6455:GDF
6419:BMP
6338:GDF
6240:GDF
6166:GDF
6118:BMP
5978:GDF
5869:GDF
5764:BMP
5657:BMP
5533:GDF
5518:BMP
5391:PGF
5175:EGF
5027:KGF
4636:BMP
4416:or
4247:PDB
4209:PMC
4201:doi
4168:doi
4139:doi
4104:PMC
4096:doi
4061:doi
4026:PMC
4018:doi
3977:doi
3940:doi
3903:doi
3874:doi
3843:PMC
3835:doi
3831:112
3794:doi
3790:284
3757:doi
3698:doi
3673:doi
3644:doi
3613:doi
3609:274
3578:doi
3545:doi
3541:331
3498:doi
3494:490
3461:PMC
3451:doi
3404:doi
3392:262
3359:PMC
3351:doi
3310:doi
3306:273
3269:doi
3265:269
3230:doi
3226:355
3193:PMC
3185:doi
3181:302
3144:doi
3140:167
3105:doi
3101:272
3068:doi
3018:doi
3014:178
2975:doi
2971:213
2933:doi
2896:doi
2847:doi
2843:140
2808:doi
2754:doi
2742:316
2705:PMC
2697:doi
2656:doi
2652:258
2603:doi
2566:PMC
2558:doi
2393:in
2130:of
2122:or
375:End
274:End
177:OMA
165:540
153:MGI
57:PDB
7057::
6932:,
6928:,
6914:,
6825:,
6811:,
6772:,
6768:,
6764:,
6760:,
6736:,
6732:,
6728:,
6716:AB
6714:,
6710:,
6668:,
6654:,
6622:15
6620:,
6616:,
6612:,
6608:,
6604:,
6600:,
6596:,
6572:,
6570:8B
6568:,
6566:8A
6564:,
6560:,
6556:,
6552:,
6548:,
6536:AB
6534:,
6530:,
6493:,
6469:,
6465:,
6461:,
6439:10
6437:,
6433:,
6429:,
6425:,
6358:,
6354:,
6274:,
6250:,
6246:,
6186:15
6184:,
6180:,
6176:,
6172:,
6148:,
6146:8B
6144:,
6142:8A
6140:,
6136:,
6132:,
6128:,
6124:,
6002:,
5998:,
5984:,
5922:,
5908:,
5879:,
5875:,
5863:AB
5861:,
5857:,
5792:8B
5790:,
5788:8A
5786:,
5782:,
5778:,
5774:,
5770:,
5698:,
5694:,
5677:8B
5675:,
5673:8A
5671:,
5667:,
5663:,
5641:AB
5639:,
5635:,
5553:,
5549:,
5522:10
5507:AB
5505:,
5501:,
4638:,
4634:,
4394::
4253::
4225:.
4217:.
4207:.
4197:40
4195:.
4191:.
4174:.
4164:18
4162:.
4145:.
4135:19
4133:.
4129:.
4112:.
4102:.
4090:.
4086:.
4069:.
4057:27
4055:.
4051:.
4034:.
4024:.
4014:10
4012:.
4008:.
3991:.
3983:.
3973:24
3971:.
3954:.
3946:.
3934:.
3917:.
3909:.
3899:23
3897:.
3880:.
3870:24
3868:.
3851:.
3841:.
3829:.
3825:.
3808:.
3800:.
3788:.
3771:.
3763:.
3753:43
3751:.
3732::
3730:}}
3726:{{
3714:.
3704:.
3679:.
3669:11
3667:.
3650:.
3640:20
3638:.
3621:.
3607:.
3603:.
3586:.
3574:51
3572:.
3568:.
3551:.
3539:.
3512:.
3504:.
3492:.
3469:.
3459:.
3449:.
3439:97
3437:.
3433:.
3410:.
3402:.
3390:.
3367:.
3357:.
3347:11
3345:.
3341:.
3318:.
3304:.
3300:.
3277:.
3263:.
3259:.
3236:.
3224:.
3201:.
3191:.
3179:.
3175:.
3152:.
3138:.
3134:.
3111:.
3099:.
3076:.
3062:.
3058:.
3046:^
3032:.
3024:.
3012:.
2989:.
2981:.
2969:.
2965:.
2953:^
2939:.
2929:26
2927:.
2904:.
2892:15
2890:.
2886:.
2863:.
2855:.
2841:.
2837:.
2814:.
2804:16
2802:.
2798:.
2782:^
2768:.
2760:.
2752:.
2740:.
2736:.
2713:.
2703:.
2693:11
2691:.
2687:.
2664:.
2650:.
2646:.
2609:.
2599:66
2597:.
2574:.
2564:.
2554:66
2552:.
2548:.
2529:.
2511:.
2482:^
2461:^
2330:,
2290:,
2177:,
2159:.
2142:,
2138:,
1789:/
381:bp
368:bp
280:bp
267:bp
175:;
171::
167:;
163::
159:;
155::
151:;
147::
100:,
96:,
92:,
88:,
6936:)
6934:3
6930:2
6926:1
6924:(
6918:)
6916:B
6912:A
6910:(
6855:)
6851:(
6829:)
6827:2
6823:1
6821:(
6815:)
6813:B
6809:A
6807:(
6776:)
6762:3
6758:1
6756:(
6740:)
6738:7
6734:6
6730:4
6726:2
6724:(
6718:)
6712:B
6708:A
6706:(
6672:)
6670:2
6666:1
6664:(
6658:)
6656:B
6652:A
6650:(
6624:)
6614:9
6598:3
6594:1
6592:(
6576:)
6562:7
6558:6
6554:5
6550:4
6546:2
6544:(
6538:)
6532:B
6528:A
6526:(
6513:)
6509:(
6497:)
6495:B
6491:A
6489:(
6473:)
6457:(
6441:)
6435:7
6431:6
6427:4
6423:2
6421:(
6362:)
6360:3
6356:2
6352:1
6350:(
6344:)
6340:(
6278:)
6276:2
6272:1
6270:(
6254:)
6248:3
6244:1
6242:(
6229:)
6225:(
6188:)
6182:9
6168:(
6152:)
6138:7
6134:6
6130:5
6126:4
6122:2
6120:(
6107:)
6103:(
6006:)
6004:3
6000:2
5996:1
5994:(
5988:)
5980:(
5962:)
5958:(
5926:)
5924:2
5920:1
5918:(
5912:)
5910:B
5906:A
5904:(
5883:)
5877:3
5873:1
5871:(
5865:)
5859:B
5855:A
5853:(
5840:)
5836:(
5794:)
5784:7
5780:6
5776:5
5772:4
5768:2
5766:(
5748:)
5744:(
5702:)
5700:3
5696:2
5692:1
5690:(
5679:)
5669:7
5665:6
5661:5
5659:(
5643:)
5637:B
5633:A
5631:(
5618:)
5614:(
5557:)
5555:3
5551:2
5547:1
5545:(
5539:)
5535:(
5524:)
5520:(
5509:)
5503:B
5499:A
5497:(
5484:)
5480:(
5446:e
5439:t
5432:v
5314:3
5309:2
5304:1
5069:/
5065:/
5056:/
5052:/
5043:/
5039:/
5013:/
5009:/
5000:/
4996:/
4956:e
4949:t
4942:v
4816:)
4807:(
4801:)
4777:(
4765:/
4642:)
4630:(
4384:e
4377:t
4370:v
4293:e
4286:t
4279:v
4263:.
4233:.
4203::
4182:.
4170::
4153:.
4141::
4120:.
4098::
4092:3
4077:.
4063::
4042:.
4020::
3999:.
3979::
3962:.
3942::
3936:4
3925:.
3905::
3888:.
3876::
3859:.
3837::
3816:.
3796::
3779:.
3759::
3742:)
3722:.
3700::
3687:.
3675::
3658:.
3646::
3629:.
3615::
3594:.
3580::
3559:.
3547::
3520:.
3500::
3477:.
3453::
3445::
3418:.
3406::
3398::
3375:.
3353::
3326:.
3312::
3285:.
3271::
3244:.
3232::
3209:.
3187::
3160:.
3146::
3119:.
3107::
3084:.
3070::
3064:1
3040:.
3020::
2997:.
2977::
2947:.
2935::
2912:.
2898::
2871:.
2849::
2822:.
2810::
2776:.
2756::
2748::
2721:.
2699::
2672:.
2658::
2631:.
2617:.
2605::
2582:.
2560::
2533:.
2515:.
2448:.
2436:,
2425:,
2360:)
2358:2
299:)
196:)
179::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
