1092:/cytokine-mediated differentiation/proliferation. Furthermore, depletion of THOC5 influences less than 1% of total mRNA export in the steady state, however it influences more than 90% of growth factor/cytokine induced genes. THOC5, thereby contributes to the 3′ processing and/or export of immediate-early genes induced by extracellular stimuli. These studies bring new insight into the link between the mRNA export complex and immediate-early gene response. The data from these studies also suggest that THOC5 may be a useful tool for studying stem cell biology, for modifying the differentiation processes and for
242:
219:
116:
141:
500:
493:
248:
147:
1271:
Mancini, A., Niemann-Seyde, S. C., Pankow, R., El
Bounkari, O., Klebba-Färber, S., Koch, A., EJaworska, E., Spooncer, E., Gruber, A. D. , Whetton, A. D., Tamura, T. (2010) THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biology
1202:
Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Farber S, Koch A, Kracht M, Whetton AD, Tamura T (2013) Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation. Cell death &
1212:
Saran S, Tran DD, Klebba-Farber S, Moran-Losada P, Wiehlmann L, Koch A, Chopra H, Pabst O, Hoffmann A, Klopfleisch R, Tamura T (2013) THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial
1364:
Xie YG, Han FY, Peyrard M, Ruttledge MH, Fransson I, DeJong P, Collins J, Dunham I, Nordenskjold M, Dumanski JP (Dec 1993). "Cloning of a novel, anonymous gene from a megabase-range YAC and cosmid contig in the neurofibromatosis type 2/meningioma region on human chromosome 22q12".
1291:
Mancini A., Koch A., Whetton A.D., and Tamura T. (2004)The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation and thereby potentiates M-CSF-mediated differentiation. Oncogene, 23,
1281:
Mancini, A., El
Bounkari, O., Norrenbrock, A-F., Scherr, M., Schaefer, D., Eder M., Banham, A. H., Pulford, K., Lyne, L., Whetton A. D., and Tamura, T. (2007) FMIP controls the adipocyte lineage commitment of C2C12 cells by down-modulation of C/EBPalpha. Oncogene 26,
1757:
Mancini A, Koch A, Whetton AD, Tamura T (2004). "The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation".
1222:
Griaud, F., Pierce, A., Gonzalez
Sanchez, M.B., Scott, M., Abraham, S.A., Holyoake, T.L., Tran, D.D., Tamura, T., and Whetton, A.D. (2013). A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5. Leukemia 27,
1476:
Pierce A, Carney L, Hamza HG, Griffiths JR, Zhang L, Whetton BA, Gonzalez
Sanchez MB, Tamura T, Sternberg D, Whetton AD (May 2008). "THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover".
1192:
Tran DDH, Koch A and Tamura T. THOC5, a member of the mRNA export complex: a novel link between mRNA export machinery and signal transduction pathways in cell proliferation and differentiation. Cell
Communication and Signaling 2014,
1251:
Ramachandran S., Tran DD., Klebba-Faerber S., Kardinal C., Whetton AD., Tamura T. An ataxia-teleaniectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA 17(11):1957-66,
1261:
Guria A., Tran D.D.H,Ramachandran S.,Koch A.,Bounkari O.,Dutta P,Hauser H,Tamura T. Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts, RNA, 2011
1312:
Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export".
1232:
Katahira J, Okuzaki D, Inoue H, Yoneda Y, Maehara K, Ohkawa Y (2013) Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I. Nucleic Acids
Research 41:
1301:
Tamura, T., Mancini, A., Joos, H., Koch, A., Hakim, C., Dumanski, J., Weidner, K.M., and
Niemann, H. (1999) FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage. Oncogene, 18,
1441:
Carney L, Pierce A, Rijnen M, Gonzalez
Sanchez MB, Hamzah HG, Zhang L, Tamura T, Whetton AD (Dec 2008). "THOC5 couples M-CSF receptor signaling to transcription factor expression".
1242:
Katahira J, Inoue H, Hurt E, Yoneda Y (2009) Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. The EMBO Journal 28: 556-567
255:
154:
1402:"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
1603:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
753:
77:
734:
1175:
1978:
1157:
1632:
Tamura T, Mancini A, Joos H, et al. (2000). "FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation".
1539:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
241:
977:
218:
984:
1520:
1144:
1123:
140:
115:
1140:
1885:"Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1"
1119:
57:
254:
153:
1400:
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999).
247:
146:
798:
65:
1842:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
779:
1073:
at multiple residues upon extracellular stimuli. These include stimulation with growth factors/cytokines/
129:
1682:
1322:
44:
935:
931:
927:
876:
872:
868:
1783:
1657:
1502:
1346:
1084:
Recent THOC5 knockout mouse data reveal that THOC5 is an essential element in the maintenance of
89:
1671:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
960:
939:
901:
880:
1941:
1906:
1871:
1828:
1775:
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1710:
1649:
1620:
1591:
1556:
1494:
1458:
1423:
1382:
1338:
499:
37:
1931:
1896:
1861:
1853:
1818:
1808:
1767:
1735:
1700:
1690:
1641:
1612:
1581:
1548:
1486:
1450:
1413:
1374:
1330:
334:
265:
209:
164:
492:
85:
1066:
309:
1686:
1326:
1093:
1078:
1070:
1866:
1841:
1823:
1796:
1705:
1670:
1616:
668:
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658:
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648:
643:
638:
633:
628:
623:
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613:
597:
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587:
582:
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572:
567:
551:
546:
541:
1972:
1552:
1490:
1089:
1062:
528:
1787:
1661:
1506:
69:
1920:"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"
1350:
1051:
327:
106:
1454:
93:
1180:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1162:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1081:
tyrosine kinases, suggesting that THOC5 may be involved in cancer development.
1936:
1919:
1901:
1884:
410:
226:
123:
73:
1960:
1813:
1724:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1570:"Normalization and subtraction: two approaches to facilitate gene discovery"
1418:
1401:
1085:
1074:
1058:
698:
470:
348:
293:
280:
192:
179:
81:
1945:
1910:
1875:
1832:
1779:
1771:
1749:
1714:
1695:
1653:
1645:
1498:
1462:
1427:
1378:
1342:
1624:
1595:
1560:
1386:
1024:
1019:
1008:
843:
824:
1077:, or DNA damage reagents. Furthermore, THOC5 is a substrate for several
1857:
1586:
1569:
1040:
810:
765:
1334:
992:
720:
1740:
1723:
1797:"A genome annotation-driven approach to cloning the human ORFeome"
683:
679:
1050:. THOCs is a member of THO complex which is a subcomplex of the
1047:
61:
508:
614:
positive regulation of DNA-templated transcription, elongation
1669:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1061:, however the exact roles of THOC5 in transcription and
317:
1840:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1795:
Collins JE, Wright CL, Edwards CA, et al. (2005).
482:
1883:
Carroll JS, Liu XS, Brodsky AS, et al. (2005).
953:
920:
894:
861:
1722:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1136:
1134:
1132:
1115:
1113:
1111:
1918:Olsen JV, Blagoev B, Gnad F, et al. (2006).
264:
163:
578:THO complex part of transcription export complex
16:Protein-coding gene in the species Homo sapiens
1141:GRCm38: Ensembl release 89: ENSMUSG00000034274
48:, C22orf19, Fmip, PK1.3, fSAP79, THO complex 5
8:
1057:THOC5 is evolutionarily conserved in higher
644:negative regulation of DNA damage checkpoint
1120:GRCh38: Ensembl release 89: ENSG00000100296
694:
524:
305:
204:
101:
1935:
1900:
1865:
1822:
1812:
1739:
1704:
1694:
1585:
1417:
1568:Bonaldo MF, Lennon G, Soares MB (1997).
639:viral mRNA export from host cell nucleus
1107:
18:
269:
230:
225:
168:
127:
122:
7:
1065:export are still unclear. THOC5 is
1521:"Entrez Gene: THOC5 THO complex 5"
950:
917:
891:
858:
834:
815:
789:
770:
744:
725:
487:
405:
343:
322:
14:
1043:that in humans is encoded by the
1491:10.1111/j.1365-2141.2008.07090.x
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
509:More reference expression data
471:More reference expression data
1:
1617:10.1016/S0378-1119(97)00411-3
1455:10.1016/j.cellsig.2008.10.018
1213:barrier. BMC Cell Biol 14: 51
1037:THO complex subunit 5 homolog
371:muscle layer of sigmoid colon
238:
137:
1979:Genes on human chromosome 22
1675:Proc. Natl. Acad. Sci. U.S.A
1553:10.1016/0378-1119(94)90802-8
1052:transcription/export complex
583:transcription export complex
363:stromal cell of endometrium
1995:
1937:10.1016/j.cell.2006.09.026
1902:10.1016/j.cell.2005.05.008
421:superior cervical ganglion
1176:"Mouse PubMed Reference:"
1158:"Human PubMed Reference:"
1023:
1018:
1014:
1007:
991:
972:
957:
924:
913:
898:
865:
854:
841:
837:
822:
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796:
792:
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773:
764:
751:
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728:
719:
704:
697:
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677:
527:
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417:
408:
355:
346:
316:
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287:
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237:
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186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1814:10.1186/gb-2004-5-10-r84
978:Chr 22: 29.51 – 29.56 Mb
664:mRNA export from nucleus
649:monocyte differentiation
659:RNA export from nucleus
433:interventricular septum
1772:10.1038/sj.onc.1207841
1696:10.1073/pnas.242603899
1646:10.1038/sj.onc.1203062
985:Chr 11: 4.85 – 4.88 Mb
669:mRNA 3'-end processing
429:neural layer of retina
1961:THOC5 on biosignaling
1419:10.1093/dnares/6.1.63
619:primitive hemopoiesis
391:right coronary artery
232:Chromosome 11 (mouse)
130:Chromosome 22 (human)
1379:10.1093/hmg/2.9.1361
629:cell differentiation
1687:2002PNAS...9916899M
1327:2002Natur.417..304S
437:seminiferous tubule
1858:10.1101/gr.2596504
1587:10.1101/gr.6.9.791
799:ENSMUSG00000034274
607:Biological process
598:nuclear chromosome
561:Cellular component
535:Molecular function
1681:(26): 16899–903.
1335:10.1038/nature746
1034:
1033:
1030:
1029:
1003:
1002:
968:
967:
947:
946:
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849:
831:
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805:
804:
786:
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741:
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689:
688:
519:
518:
515:
514:
477:
476:
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463:
402:
401:
300:
299:
199:
198:
94:THOC5 - orthologs
1986:
1949:
1939:
1914:
1904:
1879:
1869:
1836:
1826:
1816:
1791:
1753:
1743:
1718:
1708:
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1510:
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1309:
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1263:
1259:
1253:
1249:
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1234:
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1214:
1210:
1204:
1200:
1194:
1190:
1184:
1183:
1172:
1166:
1165:
1154:
1148:
1138:
1127:
1117:
1016:
1015:
987:
980:
963:
951:
942:
918:
914:RefSeq (protein)
904:
892:
883:
859:
835:
816:
790:
771:
745:
726:
695:
525:
511:
502:
495:
488:
473:
453:ventricular zone
413:
411:Top expressed in
406:
375:popliteal artery
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
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182:
171:
156:
149:
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132:
118:
102:
96:
47:
40:
19:
1994:
1993:
1989:
1988:
1987:
1985:
1984:
1983:
1969:
1968:
1966:
1957:
1952:
1917:
1882:
1852:(10B): 2121–7.
1839:
1794:
1756:
1721:
1668:
1640:(47): 6488–95.
1631:
1611:(1–2): 149–56.
1602:
1567:
1538:
1534:
1532:Further reading
1529:
1528:
1519:
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1514:
1475:
1474:
1470:
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1435:
1399:
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1394:
1363:
1362:
1358:
1321:(6886): 304–8.
1311:
1310:
1306:
1300:
1296:
1290:
1286:
1280:
1276:
1270:
1266:
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1256:
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1071:protein kinases
1025:View/Edit Mouse
1020:View/Edit Human
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973:Location (UCSC)
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780:ENSG00000100296
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624:mRNA processing
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542:protein binding
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387:ascending aorta
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367:Achilles tendon
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208:Gene location (
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105:Gene location (
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1580:(9): 791–806.
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1500:
1496:
1492:
1488:
1485:(5): 641–50.
1484:
1480:
1479:Br J Haematol
1472:
1469:
1464:
1460:
1456:
1452:
1449:(2): 309–16.
1448:
1444:
1437:
1434:
1429:
1425:
1420:
1415:
1411:
1407:
1403:
1396:
1393:
1388:
1384:
1380:
1376:
1373:(9): 1361–8.
1372:
1368:
1367:Hum Mol Genet
1360:
1357:
1352:
1348:
1344:
1340:
1336:
1332:
1328:
1324:
1320:
1316:
1308:
1305:
1298:
1295:
1288:
1285:
1278:
1275:
1268:
1265:
1258:
1255:
1248:
1245:
1239:
1236:
1229:
1226:
1219:
1216:
1209:
1206:
1199:
1196:
1189:
1186:
1181:
1177:
1171:
1168:
1163:
1159:
1153:
1150:
1146:
1142:
1137:
1135:
1133:
1129:
1125:
1121:
1116:
1114:
1112:
1108:
1101:
1099:
1097:
1095:
1091:
1090:growth factor
1087:
1082:
1080:
1076:
1072:
1068:
1064:
1060:
1055:
1053:
1049:
1046:
1042:
1038:
1026:
1021:
1017:
1013:
1010:
1006:
999:
997:
994:
990:
986:
982:
979:
975:
971:
964:
962:
956:
952:
949:
943:
941:
937:
933:
929:
923:
919:
916:
912:
905:
903:
897:
893:
890:
884:
882:
878:
874:
870:
864:
860:
857:
855:RefSeq (mRNA)
853:
846:
845:
840:
836:
833:
827:
826:
821:
817:
814:
812:
808:
801:
800:
795:
791:
788:
782:
781:
776:
772:
769:
767:
763:
756:
755:
750:
746:
743:
737:
736:
731:
727:
724:
722:
718:
715:
712:
710:
707:
703:
700:
696:
692:
685:
681:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
611:
609:
606:
605:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
574:
571:
569:
566:
565:
563:
560:
559:
553:
550:
548:
545:
543:
540:
539:
537:
534:
533:
530:
529:Gene ontology
526:
522:
510:
505:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
395:apex of heart
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:11|11 A1
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1965:
1927:
1923:
1895:(1): 33–43.
1892:
1888:
1849:
1845:
1804:
1800:
1763:
1759:
1731:
1727:
1678:
1674:
1637:
1633:
1608:
1604:
1577:
1573:
1544:
1540:
1515:
1482:
1478:
1471:
1446:
1442:
1436:
1412:(1): 63–70.
1409:
1405:
1395:
1370:
1366:
1359:
1318:
1314:
1307:
1297:
1287:
1277:
1267:
1257:
1247:
1238:
1228:
1218:
1208:
1198:
1188:
1179:
1170:
1161:
1152:
1098:
1083:
1056:
1044:
1036:
1035:
958:
936:NP_001002879
932:NP_001002878
928:NP_001002877
925:
899:
877:NM_001002879
873:NM_001002878
869:NM_001002877
866:
842:
823:
797:
778:
752:
733:
713:
708:
654:RNA splicing
552:mRNA binding
449:spermatocyte
425:otic vesicle
333:
326:
53:External IDs
1807:(10): R84.
1801:Genome Biol
1734:(1): 40–5.
1443:Cell Signal
1069:by several
593:nucleoplasm
573:THO complex
547:RNA binding
191:29,555,216
178:29,505,879
31:Identifiers
1846:Genome Res
1728:Nat. Genet
1574:Genome Res
1302:6488-6495.
1282:1020-1027.
1147:, May 2017
1126:, May 2017
1102:References
1086:stem cells
1075:chemokines
1059:eukaryotes
337:(ortholog)
292:4,878,867
279:4,845,320
74:HomoloGene
1262:17:00-00.
1233:7060-7072
1079:oncogenic
1054:(TREX).
961:NP_766026
940:NP_003669
902:NM_172438
881:NM_003678
699:Orthologs
568:cytoplasm
441:spermatid
82:GeneCards
1973:Category
1946:17081983
1911:16009131
1876:15489334
1833:15461802
1788:21923924
1780:15221008
1760:Oncogene
1750:14702039
1715:12477932
1662:32568059
1654:10597251
1634:Oncogene
1507:21122818
1499:18373705
1463:19015024
1428:10231032
1343:11979277
1223:932-940.
1143:–
1122:–
1009:Wikidata
678:Sources:
457:epiblast
1683:Bibcode
1625:9373149
1596:8889548
1561:8125298
1406:DNA Res
1387:8242058
1351:1112194
1323:Bibcode
1292:6581-9.
1145:Ensembl
1124:Ensembl
1041:protein
811:UniProt
766:Ensembl
705:Species
684:QuickGO
588:nucleus
312:pattern
170:22q12.2
70:1351333
38:Aliases
1944:
1909:
1874:
1867:528928
1864:
1831:
1824:545604
1821:
1786:
1778:
1748:
1713:
1706:139241
1703:
1660:
1652:
1623:
1594:
1559:
1505:
1497:
1461:
1426:
1385:
1349:
1341:
1315:Nature
995:search
993:PubMed
844:Q8BKT7
825:Q13769
754:107829
721:Entrez
483:BioGPS
62:612733
1784:S2CID
1658:S2CID
1503:S2CID
1347:S2CID
1272:8, 1.
1045:THOC5
1039:is a
714:Mouse
709:Human
680:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:THOC5
78:37836
45:THOC5
22:THOC5
1942:PMID
1924:Cell
1907:PMID
1889:Cell
1872:PMID
1829:PMID
1776:PMID
1746:PMID
1711:PMID
1650:PMID
1621:PMID
1605:Gene
1592:PMID
1557:PMID
1541:Gene
1495:PMID
1459:PMID
1424:PMID
1383:PMID
1339:PMID
1252:2011
1193:12:3
1088:and
1063:mRNA
1048:gene
735:8563
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1932:doi
1928:127
1897:doi
1893:122
1862:PMC
1854:doi
1819:PMC
1809:doi
1768:doi
1736:doi
1701:PMC
1691:doi
1642:doi
1613:doi
1609:200
1582:doi
1549:doi
1545:138
1487:doi
1483:141
1451:doi
1414:doi
1375:doi
1331:doi
1319:417
288:End
187:End
90:OMA
66:MGI
1975::
1940:.
1926:.
1922:.
1905:.
1891:.
1887:.
1870:.
1860:.
1850:14
1848:.
1844:.
1827:.
1817:.
1803:.
1799:.
1782:.
1774:.
1764:23
1762:.
1744:.
1732:36
1730:.
1726:.
1709:.
1699:.
1689:.
1679:99
1677:.
1673:.
1656:.
1648:.
1638:18
1636:.
1619:.
1607:.
1590:.
1576:.
1572:.
1555:.
1543:.
1501:.
1493:.
1481:.
1457:.
1447:21
1445:.
1422:.
1408:.
1404:.
1381:.
1369:.
1345:.
1337:.
1329:.
1317:.
1178:.
1160:.
1131:^
1110:^
1096:.
682:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1948:.
1934::
1913:.
1899::
1878:.
1856::
1835:.
1811::
1805:5
1790:.
1770::
1752:.
1738::
1717:.
1693::
1685::
1664:.
1644::
1627:.
1615::
1598:.
1584::
1578:6
1563:.
1551::
1523:.
1509:.
1489::
1465:.
1453::
1430:.
1416::
1410:6
1389:.
1377::
1371:2
1353:.
1333::
1325::
1182:.
1164:.
212:)
109:)
92::
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