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1259:. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates
323:
222:
50:
1275:, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
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123:, BACTS1, Mal, MyD88-2, wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, TIR domain containing adaptor protein
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Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations
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National Center for
Biotechnology Information, U.S. National Library of Medicine
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National Center for
Biotechnology Information, U.S. National Library of Medicine
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positive regulation of chemokine (C-X-C motif) ligand 2 production
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positive regulation of chemokine (C-X-C motif) ligand 1 production
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863:
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136:
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positive regulation of NF-kappaB transcription factor activity
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positive regulation of toll-like receptor 2 signaling pathway
813:
positive regulation of toll-like receptor 4 signaling pathway
713:
positive regulation of toll-like receptor 3 signaling pathway
818:
positive regulation of I-kappaB kinase/NF-kappaB signaling
753:
positive regulation of protein homodimerization activity
392:
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808:
positive regulation of tumor necrosis factor production
768:
TIRAP-dependent toll-like receptor 4 signaling pathway
557:
743:
MyD88-dependent toll-like receptor signaling pathway
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1153:
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1600:
1598:
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853:activation of NF-kappaB-inducing kinase activity
748:positive regulation of interleukin-15 production
718:positive regulation of interleukin-12 production
793:positive regulation of interleukin-8 production
16:Protein-coding gene in the species Homo sapiens
1628:GRCm38: Ensembl release 89: ENSMUSG00000032041
1387:
1356:
631:phosphatidylinositol-4,5-bisphosphate binding
8:
803:positive regulation of neutrophil chemotaxis
798:positive regulation of ERK1 and ERK2 cascade
1607:GRCh38: Ensembl release 89: ENSG00000150455
843:defense response to Gram-positive bacterium
778:positive regulation of B cell proliferation
1394:
1380:
1372:
1363:
1349:
878:
708:cellular response to bacterial lipopeptide
583:
380:
279:
176:
58:
1307:at the U.S. National Library of Medicine
1255:) is an adapter molecule associated with
783:regulation of interferon-beta production
1594:
758:cell surface receptor signaling pathway
773:cellular response to lipoteichoic acid
601:protein-macromolecule adaptor activity
18:
1253:TIR domain containing adaptor protein
344:
305:
300:
243:
202:
197:
7:
1317:
1315:
703:regulation of innate immune response
626:protein heterodimerization activity
1335:. You can help Knowledge (XXG) by
1150:
1117:
1079:
1042:
1018:
999:
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928:
909:
828:3'-UTR-mediated mRNA stabilization
738:positive regulation of JNK cascade
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606:protein homodimerization activity
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763:response to lipopolysaccharide
546:More reference expression data
1:
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212:
1686:Genes on human chromosome 11
698:myeloid cell differentiation
616:Toll-like receptor 4 binding
611:Toll-like receptor 2 binding
1707:
1314:
516:sternocleidomastoid muscle
1663:"Mouse PubMed Reference:"
1645:"Human PubMed Reference:"
1235:
1230:
1226:
1219:
1203:
1190:Chr 11: 126.28 – 126.3 Mb
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1157:
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641:identical protein binding
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1309:Medical Subject Headings
636:protein kinase C binding
504:vastus lateralis muscle
1283:
1197:Chr 9: 35.1 – 35.11 Mb
848:innate immune response
500:triceps brachii muscle
1520:Downstream signalling
1281:
833:inflammatory response
733:immune system process
470:minor salivary glands
205:Chromosome 11 (human)
1305:TIRAP+protein,+human
454:smooth muscle tissue
307:Chromosome 9 (mouse)
62:List of PDB id codes
35:Available structures
1257:toll-like receptors
838:signal transduction
512:conjunctival fornix
466:right lobe of liver
446:islet of Langerhans
1691:Biochemistry stubs
1284:
983:ENSMUSG00000032041
691:Biological process
650:Cellular component
594:Molecular function
434:buccal mucosa cell
1591:
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1409:signaling pathway
1403:Signaling pathway
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442:bone marrow cells
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169:TIRAP - orthologs
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45:Ortholog search:
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1114:RefSeq (protein)
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1493:Other receptors
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1237:View/Edit Mouse
1232:View/Edit Human
1195:
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1185:Location (UCSC)
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964:ENSG00000150455
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682:ruffle membrane
672:plasma membrane
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621:protein binding
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524:temporal muscle
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508:muscle of thigh
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283:Gene location (
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180:Gene location (
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1039:RefSeq (mRNA)
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588:Gene ontology
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532:parotid gland
531:
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1572:
1337:expanding it
1329:biochemistry
1326:
1252:
1248:
1247:
1169:NP_001171318
1165:NP_001171317
1161:NP_001171316
1158:
1136:NP_001305706
1132:NP_001305705
1128:NP_001034750
1125:
1098:NM_001177847
1094:NM_001177846
1090:NM_001177845
1087:
1069:NM_001318777
1065:NM_001318776
1053:NM_001039661
1050:
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1007:
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408:
401:
266:126,298,845
253:126,283,065
128:External IDs
67:
496:granulocyte
462:right ovary
367:35,111,587
354:35,095,847
346:9|9 A4
106:Identifiers
1680:Categories
1634:, May 2017
1613:, May 2017
1261:NF-kappa-B
528:knee joint
458:left ovary
412:(ortholog)
149:HomoloGene
1173:NP_473437
1140:NP_683708
1102:NM_054096
1061:NM_148910
1057:NM_052887
883:Orthologs
657:cytoplasm
157:GeneCards
1630:–
1609:–
1287:See also
1221:Wikidata
862:Sources:
667:membrane
438:monocyte
1632:Ensembl
1611:Ensembl
995:UniProt
950:Ensembl
889:Species
868:QuickGO
662:cytosol
387:pattern
245:11q24.2
145:2152213
113:Aliases
1578:TOLLIP
1568:TICAM1
1553:MAP3K7
1311:(MeSH)
1207:search
1205:PubMed
1028:Q99JY1
1009:P58753
938:117149
919:114609
905:Entrez
558:BioGPS
450:rectum
137:606252
1583:TRAF6
1573:TIRAP
1558:MYD88
1543:IRAK4
1538:IRAK3
1533:IRAK2
1528:IRAK1
1484:TLR13
1479:TLR12
1474:TLR11
1469:TLR10
1327:This
1293:Myd88
1269:MAPK3
1265:MAPK1
1249:TIRAP
898:Mouse
893:Human
864:Amigo
410:Mouse
403:Human
350:Start
285:Mouse
249:Start
182:Human
161:TIRAP
153:14285
120:TIRAP
22:TIRAP
1563:TAB1
1548:IRF3
1500:CD14
1464:TLR9
1459:TLR8
1454:TLR7
1449:TLR6
1444:TLR5
1439:TLR4
1434:TLR3
1429:TLR2
1424:TLR1
1416:TLRs
1333:stub
1271:and
393:Bgee
341:Band
302:Chr.
240:Band
199:Chr.
133:OMIM
90:4LQD
86:4FZ5
82:3UB4
78:3UB3
74:3UB2
70:2Y92
51:RCSB
48:PDBe
1510:MD2
1505:LBP
1407:TLR
1273:JNK
566:n/a
363:End
262:End
165:OMA
141:MGI
41:PDB
1682::
1665:.
1647:.
1618:^
1597:^
1405::
1267:,
1263:,
866:/
369:bp
356:bp
268:bp
255:bp
163:;
159::
155:;
151::
147:;
143::
139:;
135::
88:,
84:,
80:,
76:,
72:,
1669:.
1651:.
1395:e
1388:t
1381:v
1364:e
1357:t
1350:v
1339:.
1251:(
287:)
184:)
167::
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