242:
219:
116:
141:
493:
248:
147:
852:
This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in
1033:
profiles showed that TMEM50A is highly upregulated in late stage cervical cancer. This may suggest that TMEM50A has some function that may be causing or is caused directly by cervical cancer. Although few studies are available to confirm this idea, more studies may offer suggestions that use TMEM50A
1030:
861:
The TMEM50A gene is located on chromosome 1 p36.11 in the human (homo sapiens) genome. Its mRNA sequence is 2284 base pairs in length and includes seven exons. The coding sequence is from base pairs 151 to 624.
1008:
profiles through NCBI, suggests that its expression may be slightly higher in parathyroid tissues and brain tissues. It also seems to be expressed higher during the neonate and juvenile development stages.
1018:
936:
shows that TMEM50A has four transmembrane regions. This was further confirmed by similar results found in TMEM50A orthologs and the neutral charge found in these regions using
255:
154:
1350:
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry".
1475:"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment"
929:
The exact structure of TMEM50A is unknown but through the use of several prediction programs, some of its most likely structural components can be assumed.
576:
557:
77:
1111:
1093:
1743:
241:
783:
776:
218:
1194:
996:
These alternative splice sites don't affect the reading frame of the sequence and thus may not alter the function of the protein.
853:
this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes.
1080:
1059:
1267:
902:
1076:
140:
115:
1055:
1649:"Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs"
57:
878:
254:
153:
247:
146:
621:
65:
1432:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
1005:
602:
881:
predicts that TMEM50A is most likely found in the cells plasma membrane or the endoplasmic reticulum.
1529:
1221:
1021:. This proteins gene is located on chromosome 7 open reading frame 43. Its function is also unknown.
129:
44:
946:
along with comparing the results of known protein structures, it can be predicted that TMEM50A has:
1606:"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing"
1375:
89:
1518:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
759:
738:
712:
691:
492:
1721:
1678:
1635:
1592:
1557:
1504:
1461:
1418:
1367:
1338:
1249:
1173:
1138:
896:
37:
85:
1711:
1703:
1668:
1660:
1625:
1617:
1582:
1547:
1537:
1494:
1486:
1451:
1443:
1408:
1400:
1359:
1328:
1320:
1239:
1229:
1165:
334:
265:
209:
164:
309:
1533:
1225:
1630:
1605:
1333:
1308:
889:
Through bioinformatic analysis several of TMEM50A's protein properties were predicted.
1716:
1691:
1673:
1648:
1552:
1517:
1499:
1474:
1456:
1431:
1413:
1388:
971:
1737:
1244:
1209:
912:
1379:
69:
327:
106:
1621:
1271:
1156:
Wagner FF, Flegel WA (Aug 2000). "RHD gene deletion occurred in the Rhesus box".
93:
1116:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1098:
National Center for
Biotechnology Information, U.S. National Library of Medicine
957:
950:
1587:
1570:
1214:
Proceedings of the
National Academy of Sciences of the United States of America
410:
1169:
226:
123:
73:
1571:"RHCE represents the ancestral RH position, while RHD is the duplicated gene"
521:
470:
348:
293:
280:
192:
179:
81:
1725:
1682:
1639:
1596:
1561:
1542:
1508:
1465:
1422:
1371:
1342:
1234:
1177:
1142:
1253:
823:
818:
1324:
1288:
1208:
Brendel V, Bucher P, Nourbakhsh IR, Blaisdell BE, Karlin S (March 1992).
807:
666:
647:
933:
1664:
1490:
1447:
1404:
908:
Two serine phosphorylation sites found at amino acids 82 and 84 Residue
839:
633:
588:
1707:
1210:"Methods and algorithms for statistical analysis of protein sequences"
1363:
791:
543:
1004:
TMEM50A is expressed in almost all human tissues, but evidence from
846:
501:
61:
1129:
Flegel WA, Wagner FF (Dec 2000). "Molecular genetics of RH".
943:
937:
1604:
Simpson JC, Wellenreuther R, Poustka A, et al. (2001).
1017:
There is one predicted protein that interacts with TMEM50A,
1516:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
905:: Several post-translational modifications are predicted:
1389:"From ORFeome to Biology: A Functional Genomics Pipeline"
1692:"DNA Cloning Using In Vitro Site-Specific Recombination"
1647:
Wiemann S, Weil B, Wellenreuther R, et al. (2001).
317:
1430:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1307:
Mehrle A, Rosenfelder H, Schupp I, et al. (2006).
482:
976:TMEM50A has several alternative splices including:
970:Alternative Splice sites were found by BLAT on the
752:
731:
705:
684:
1473:Clark HF, Gurney AL, Abaya E, et al. (2003).
1072:
1070:
1068:
1051:
1049:
1047:
870:The TMEM50A protein is 157 amino acids in length.
264:
163:
1387:Wiemann S, Arlt D, Huber W, et al. (2004).
1195:"Entrez Gene: TMEM50A transmembrane protein 50A"
16:Protein-coding gene in the species Homo sapiens
1077:GRCm38: Ensembl release 89: ENSMUSG00000028822
1034:for treatment of late stage cervical cancer.
8:
1268:"PI Program (Isoelectric Point Prediction)"
1056:GRCh38: Ensembl release 89: ENSG00000183726
1283:
1281:
918:One possible Tyrosine phosphorylation site
517:
305:
204:
101:
1715:
1690:Hartley JL, Temple GF, Brasch MA (2001).
1672:
1629:
1586:
1551:
1541:
1498:
1455:
1412:
1332:
1243:
1233:
1189:
1187:
48:, IFNRC, SMP1, transmembrane protein 50A
1043:
18:
269:
230:
225:
168:
127:
122:
7:
749:
728:
702:
681:
657:
638:
612:
593:
567:
548:
487:
405:
343:
322:
14:
944:PELE program in Biology Workbench
938:SAPS program in Biology Workbench
842:that in humans is encoded by the
491:
253:
246:
240:
217:
152:
145:
139:
114:
903:Post-translational modification
915:Site located at amino acid 74
502:More reference expression data
471:More reference expression data
1:
1569:Wagner FF, Flegel WA (2002).
1309:"The LIFEdb database in 2006"
238:
137:
1522:Proc. Natl. Acad. Sci. U.S.A
986:Removal of exons 2, 3, and 5
1744:Genes on human chromosome 1
1622:10.1093/embo-reports/kvd058
1025:Future Medical Applications
893:Molecular Weight: 17.4 KDal
1760:
1588:10.1182/blood-2001-12-0153
1319:(Database issue): D415–8.
1170:10.1182/blood.V95.12.3662
1112:"Mouse PubMed Reference:"
1094:"Human PubMed Reference:"
1029:Investigation of several
836:Transmembrane protein 50A
822:
817:
813:
806:
790:
784:Chr 4: 134.63 – 134.64 Mb
771:
756:
735:
724:
709:
688:
677:
664:
660:
645:
641:
632:
619:
615:
600:
596:
587:
574:
570:
555:
551:
542:
527:
520:
516:
499:
490:
481:
468:
417:
408:
363:epithelium of nasopharynx
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
983:Removal of exons 2 and 3
777:Chr 1: 25.34 – 25.36 Mb
391:mucosa of sigmoid colon
1543:10.1073/pnas.242603899
1235:10.1073/pnas.89.6.2002
913:N-Linked Glycosylation
441:stroma of bone marrow
367:palpebral conjunctiva
1013:Interacting Proteins
885:Predicted properties
271:4 D3|4 67.14 cM
232:Chromosome 4 (mouse)
130:Chromosome 1 (human)
1534:2002PNAS...9916899M
1226:1992PNAS...89.2002B
1137:(Suppl 2): 109–15.
972:UCSC genome browser
395:gingival epithelium
94:TMEM50A - orthologs
1665:10.1101/gr.GR1547R
1491:10.1101/gr.1293003
1448:10.1101/gr.2596504
1405:10.1101/gr.2576704
1325:10.1093/nar/gkj139
1289:"UniProt Database"
622:ENSMUSG00000028822
1708:10.1101/gr.143000
1528:(26): 16899–903.
1313:Nucleic Acids Res
992:Removal of exon 5
989:Removal of exon 3
980:Removal of exon 2
897:Isoelectric point
874:Cellular Location
833:
832:
829:
828:
802:
801:
767:
766:
746:
745:
720:
719:
699:
698:
673:
672:
654:
653:
628:
627:
609:
608:
583:
582:
564:
563:
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
383:corpus epididymis
300:
299:
199:
198:
1751:
1729:
1719:
1686:
1676:
1643:
1633:
1600:
1590:
1565:
1555:
1545:
1512:
1502:
1469:
1459:
1426:
1416:
1399:(10B): 2136–44.
1383:
1364:10.1038/nmeth776
1346:
1336:
1293:
1292:
1285:
1276:
1275:
1270:. Archived from
1264:
1258:
1257:
1247:
1237:
1205:
1199:
1198:
1191:
1182:
1181:
1153:
1147:
1146:
1126:
1120:
1119:
1108:
1102:
1101:
1090:
1084:
1074:
1063:
1053:
815:
814:
786:
779:
762:
750:
741:
729:
725:RefSeq (protein)
715:
703:
694:
682:
658:
639:
613:
594:
568:
549:
518:
504:
495:
488:
473:
413:
411:Top expressed in
406:
387:lactiferous duct
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1759:
1758:
1754:
1753:
1752:
1750:
1749:
1748:
1734:
1733:
1732:
1702:(11): 1788–95.
1689:
1646:
1603:
1568:
1515:
1485:(10): 2265–70.
1472:
1442:(10B): 2121–7.
1429:
1386:
1349:
1306:
1302:
1300:Further reading
1297:
1296:
1287:
1286:
1279:
1266:
1265:
1261:
1207:
1206:
1202:
1193:
1192:
1185:
1155:
1154:
1150:
1128:
1127:
1123:
1110:
1109:
1105:
1092:
1091:
1087:
1075:
1066:
1054:
1045:
1040:
1027:
1015:
1002:
968:
927:
887:
876:
868:
859:
824:View/Edit Mouse
819:View/Edit Human
782:
775:
772:Location (UCSC)
758:
737:
711:
690:
603:ENSG00000183726
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1757:
1755:
1747:
1746:
1736:
1735:
1731:
1730:
1687:
1644:
1601:
1566:
1513:
1470:
1427:
1384:
1347:
1303:
1301:
1298:
1295:
1294:
1277:
1274:on 2008-10-26.
1259:
1200:
1183:
1164:(12): 3662–8.
1148:
1121:
1103:
1085:
1064:
1042:
1041:
1039:
1036:
1026:
1023:
1014:
1011:
1001:
998:
994:
993:
990:
987:
984:
981:
967:
964:
963:
962:
961:
960:
954:
940:
926:
923:
922:
921:
920:
919:
916:
909:
900:
894:
886:
883:
875:
872:
867:
864:
858:
855:
831:
830:
827:
826:
821:
811:
810:
804:
803:
800:
799:
797:
795:
788:
787:
780:
773:
769:
768:
765:
764:
754:
753:
747:
744:
743:
733:
732:
726:
722:
721:
718:
717:
707:
706:
700:
697:
696:
686:
685:
679:
675:
674:
671:
670:
662:
661:
655:
652:
651:
643:
642:
636:
630:
629:
626:
625:
617:
616:
610:
607:
606:
598:
597:
591:
585:
584:
581:
580:
572:
571:
565:
562:
561:
553:
552:
546:
540:
539:
534:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1756:
1745:
1742:
1741:
1739:
1727:
1723:
1718:
1713:
1709:
1705:
1701:
1697:
1693:
1688:
1684:
1680:
1675:
1670:
1666:
1662:
1659:(3): 422–35.
1658:
1654:
1650:
1645:
1641:
1637:
1632:
1627:
1623:
1619:
1616:(3): 287–92.
1615:
1611:
1607:
1602:
1598:
1594:
1589:
1584:
1581:(6): 2272–3.
1580:
1576:
1572:
1567:
1563:
1559:
1554:
1549:
1544:
1539:
1535:
1531:
1527:
1523:
1519:
1514:
1510:
1506:
1501:
1496:
1492:
1488:
1484:
1480:
1476:
1471:
1467:
1463:
1458:
1453:
1449:
1445:
1441:
1437:
1433:
1428:
1424:
1420:
1415:
1410:
1406:
1402:
1398:
1394:
1390:
1385:
1381:
1377:
1373:
1369:
1365:
1361:
1357:
1353:
1348:
1344:
1340:
1335:
1330:
1326:
1322:
1318:
1314:
1310:
1305:
1304:
1299:
1290:
1284:
1282:
1278:
1273:
1269:
1263:
1260:
1255:
1251:
1246:
1241:
1236:
1231:
1227:
1223:
1220:(6): 2002–6.
1219:
1215:
1211:
1204:
1201:
1196:
1190:
1188:
1184:
1179:
1175:
1171:
1167:
1163:
1159:
1152:
1149:
1144:
1140:
1136:
1132:
1125:
1122:
1117:
1113:
1107:
1104:
1099:
1095:
1089:
1086:
1082:
1078:
1073:
1071:
1069:
1065:
1061:
1057:
1052:
1050:
1048:
1044:
1037:
1035:
1032:
1024:
1022:
1020:
1012:
1010:
1007:
999:
997:
991:
988:
985:
982:
979:
978:
977:
974:
973:
965:
959:
955:
952:
948:
947:
945:
942:By using the
941:
939:
935:
932:
931:
930:
924:
917:
914:
910:
907:
906:
904:
901:
898:
895:
892:
891:
890:
884:
882:
880:
873:
871:
865:
863:
856:
854:
850:
848:
845:
841:
837:
825:
820:
816:
812:
809:
805:
798:
796:
793:
789:
785:
781:
778:
774:
770:
763:
761:
755:
751:
748:
742:
740:
734:
730:
727:
723:
716:
714:
708:
704:
701:
695:
693:
687:
683:
680:
678:RefSeq (mRNA)
676:
669:
668:
663:
659:
656:
650:
649:
644:
640:
637:
635:
631:
624:
623:
618:
614:
611:
605:
604:
599:
595:
592:
590:
586:
579:
578:
573:
569:
566:
560:
559:
554:
550:
547:
545:
541:
538:
535:
533:
530:
526:
523:
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
449:otolith organ
448:
444:
440:
436:
432:
428:
424:
421:adrenal gland
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
375:parotid gland
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1699:
1695:
1656:
1652:
1613:
1609:
1578:
1574:
1525:
1521:
1482:
1478:
1439:
1435:
1396:
1392:
1358:(8): 591–8.
1355:
1352:Nat. Methods
1351:
1316:
1312:
1272:the original
1262:
1217:
1213:
1203:
1161:
1157:
1151:
1134:
1130:
1124:
1115:
1106:
1097:
1088:
1028:
1016:
1003:
995:
975:
969:
966:Splice Sites
928:
911:One possible
888:
877:
869:
860:
851:
843:
835:
834:
757:
736:
710:
689:
665:
646:
620:
601:
575:
556:
536:
531:
333:
326:
292:134,642,335
279:134,625,160
53:External IDs
958:Beta Sheets
951:Alpha Helix
429:granulocyte
371:pericardium
191:25,362,361
178:25,338,317
31:Identifiers
1696:Genome Res
1653:Genome Res
1479:Genome Res
1436:Genome Res
1393:Genome Res
1083:, May 2017
1062:, May 2017
1038:References
1000:Expression
953:structures
445:belly cord
337:(ortholog)
74:HomoloGene
925:Structure
760:NP_082211
739:NP_055128
713:NM_027935
692:NM_014313
522:Orthologs
82:GeneCards
1738:Category
1726:11076863
1683:11230166
1640:11256614
1610:EMBO Rep
1597:11902138
1562:12477932
1509:12975309
1466:15489334
1423:15489336
1380:20475874
1372:16094384
1343:16381901
1178:10845894
1143:10938938
1131:Vox Sang
1079:–
1058:–
879:PSORT II
808:Wikidata
433:calvaria
359:monocyte
1631:1083732
1530:Bibcode
1334:1347501
1254:1549558
1222:Bibcode
1081:Ensembl
1060:Ensembl
1019:C7orf43
899:: 5.483
866:Protein
844:TMEM50A
840:protein
634:UniProt
589:Ensembl
528:Species
453:utricle
425:decidua
312:pattern
170:1p36.11
86:TMEM50A
70:1919067
45:TMEM50A
38:Aliases
22:TMEM50A
1724:
1717:310948
1714:
1681:
1674:311072
1671:
1638:
1628:
1595:
1560:
1553:139241
1550:
1507:
1500:403697
1497:
1464:
1457:528928
1454:
1421:
1414:528930
1411:
1378:
1370:
1341:
1331:
1252:
1242:
1176:
1141:
794:search
792:PubMed
667:Q9CXL1
648:O95807
544:Entrez
483:BioGPS
437:thymus
62:605348
1575:Blood
1376:S2CID
1245:48584
1158:Blood
956:Five
934:TMHMM
838:is a
577:71817
558:23585
537:Mouse
532:Human
457:blood
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
1722:PMID
1679:PMID
1636:PMID
1593:PMID
1558:PMID
1505:PMID
1462:PMID
1419:PMID
1368:PMID
1339:PMID
1250:PMID
1174:PMID
1139:PMID
949:Two
857:Gene
847:gene
379:gums
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
78:4469
58:OMIM
1712:PMC
1704:doi
1669:PMC
1661:doi
1626:PMC
1618:doi
1583:doi
1548:PMC
1538:doi
1495:PMC
1487:doi
1452:PMC
1444:doi
1409:PMC
1401:doi
1360:doi
1329:PMC
1321:doi
1240:PMC
1230:doi
1166:doi
1031:GEO
1006:EST
288:End
187:End
90:OMA
66:MGI
1740::
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1700:10
1698:.
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1657:11
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1186:^
1172:.
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1046:^
849:.
294:bp
281:bp
193:bp
180:bp
88:;
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