933:
247:
928:
224:
121:
146:
1186:
1171:(E-value 1e-177 to 1e-124). These orthologs range from 78% to 93% sequence similarity to the human protein. Moderately related orthologs to human TMEM169 protein include fish and cephalochordates (similarity= 62%-75%; E-value= 3e-120 to 1e-71). Protein sequences of hemichordates, arthropods, and mollusks are the most distantly related to the human protein sequence (similarity= 56%-64%; E-value= 2e-58 to 1e-44). The most distantly related organism with TMEM169 ortholog is
253:
152:
952:
1672:
1088:
1152:
22:
in humans is encoded by TMEM169 gene. The aliases of TMEM169 include FLJ34263, DKFZp781L2456, and LOC92691. TMEM169 has the highest expression in the brain, particularly the fetal brain. TMEM169 has homologs mammals, reptiles, amphibians, birds, fish, chordates and invertebrates. The most distantly
881:
Transcription of TMEM169 gene produces five alternatively spliced variants to generate four variants of the transcript. The variants all code for the same protein and have differences within the 5’ UTR region. Variant 1 is the longest transcript (NM_001142310.2) and consists of 3,408 base pairs and
1695:
TMEM169 gene first appeared in invertebrates, more specifically in arthropods and mollusks. The approximate date of divergence from humans for arthropods and mollusks is 797 million years ago (MYA). Based upon comparison of the evolution for cytochrome C (a quickly evolving protein) and fibrinogen
1170:
Orthologs are found in over 300 organisms within the kingdom metazoan. There are not any orthologs found in fungi or plants. Invertebrates are the most distantly related orthologs, according to BLAST searches. The subset of closely related organisms include mammals, reptiles, birds, and amphibians
1049:
RNA sequencing data revealed TMEM169 is expressed ubiquitously, although it displays high expression in the brain, particularly during fetal development. HPA RNA-seq normal tissues for TMEM169 were obtained from 95 human tissue samples. The HPA RNA-seq demonstrates highest expression of TMEM169 in
1147:
TMEM169 is well-conserved across strict orthologs shown by the following multiple sequence alignment created
Clustal using BoxShade. The multiple sequence alignment of distant orthologs highlighting the transmembrane domains was also created using Clustal and BoxShade. The red boxes illustrate
1723:(COPD) within the international COPD genetics network. Additionally, gene TMEM169 is one of the four most down-regulated genes in response to oxidative stress; it is downregulated by 0.50 fold in patients with myocardial infarctions. The gene has association to two different birth defects;
890:
All four transcripts encode for the same protein (TMEM169) consisting of 297 amino acids. According to SAPS the molecular weight of protein TMEM169 is 33.6 kdal and it has an overall net negative charge (-5.7%). TMEM169 has an isoelectric point of 4.76.
1686:
TMEM169 protein. The table is organized by increasing DOD (data of divergence from the human lineage) and then by sequence similarity to the human protein (%). The date of divergence was calculated using TimeTree. Seq. is an abbreviation for sequence.
1069:
The use of polyclonal TMEM169 antibody (NBP2-69796) of a human melanoma cell line (SK-MEL-30) in the host of rabbit demonstrates TMEM169 localization to nucleoplasm, cytosol and centrosome. Strong positivity in glial cells is revealed through
865:
The gene is located on human chromosome 2(2q35) and spans 20,918 bases (216,081,866-216,102,783) on the + strand. The gene contains four exons in total. The direct neighbors of TMEM169 include
1731:. An amino acid change (p.K41I) in TMEM169 is known to cause neural tube defects and hypermethylated loci cg20968678, associated with TMEM169, leads to early onset preeclampsia.
903:
TMEM169 located at amino acids 160-180 and 211-231. The N and C terminus are both located in the cytoplasmic domain. The conceptual translation provides further annotation of
1061:
The highest expression of TMEM169 is found in the fetal brain. TMEM169 tends to have a high expression in the brain relative to other tissues, although not to other genes.
2479:
Pappa L, Kals M, Kivistik PA, Metspalu A, Paal A, Nikopensius T (September 2017). "Exome analysis in an
Estonian multiplex family with neural tube defects-a case report".
260:
159:
1707:(rho-related GTP-binding protein RhoU) is known to interact with TMEM169 according to PSICQUIC. The pull down assay revealed RhoU as a protein interaction with TMEM169.
1159:
TMEM169 orthologs is illustrated. The darker shade reflects higher conservation. The blue line reveals exon/exon boundary. The red boxes identify transmembrane domains.
1193:
TMEM169 orthologs is illustrated, highlighting transmembrane domains. The darker shade reflects higher conservation. The red boxes identify transmembrane domains.
2236:
572:
553:
82:
2432:"Transcriptome profiling of 3D co-cultured cardiomyocytes and endothelial cells under oxidative stress using a photocrosslinkable hydrogel system"
1906:
2052:
1888:
1720:
2579:
796:
246:
803:
1793:
223:
2207:
1875:
1854:
2025:
2001:
1716:
1871:
2308:
145:
120:
2383:"Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene"
1850:
2129:
259:
158:
948:
The promoter (GXP_6745619) is 1242 base pairs at coordinates 216080866-216082107. It supports 11 coding transcripts.
252:
151:
1929:
932:
617:
70:
1794:"AceView: Gene:TMEM169, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView"
598:
927:
1719:
of TMEM169, defined as rs3821104, is one of two SNP’s that revealed strong association (p<0.1) with
1185:
1071:
134:
57:
2060:
1173:
1050:
the brain (RPKM=3.159). Particularly, in the fetal brain (RPKM= 1.583) and cerebellum(RPKM=0.795).
754:
750:
746:
695:
691:
687:
25:
2504:
1724:
94:
779:
758:
720:
699:
2555:
2524:"Genome-scale hypomethylation in the cord blood DNAs associated with early onset preeclampsia"
2496:
2461:
2412:
2363:
50:
1099:
The MyHits Tool revealed two types of conserved predicted post-translational modifications.
90:
2545:
2535:
2488:
2451:
2443:
2402:
2394:
2353:
2345:
339:
270:
214:
169:
1118:
314:
2381:
Hersh CP, Pillai SG, Zhu G, Lomas DA, Bakke P, Gulsvik A, et al. (September 2010).
2550:
2523:
2456:
2431:
2407:
2382:
2358:
2333:
1130:
2130:"Tissue expression of TMEM169 - Staining in cerebral cortex - The Human Protein Atlas"
2105:
1696:
alpha chain (a slowly evolving protein), TMEM169 gene is evolving at a moderate pace.
1657:
1635:
1613:
1524:
1502:
1480:
1458:
1436:
1414:
1392:
1370:
1348:
1326:
1259:
1237:
2573:
2522:
Ching T, Ha J, Song MA, Tiirikainen M, Molnar J, Berry MJ, et al. (2015-03-13).
2332:
Dart AE, Box GM, Court W, Gale ME, Brown JP, Pinder SE, et al. (November 2015).
1728:
2508:
2215:
2081:
1591:
1546:
1304:
1281:
74:
1569:
951:
332:
111:
2334:"PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion"
1671:
2447:
98:
1911:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1893:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1770:"TMEM169 transmembrane protein 169 [Homo sapiens (human)] - Gene - NCBI"
916:
2398:
2237:"transmembrane protein 169-like [Anopheles albimanus] - Protein - NCBI"
1087:
415:
2540:
2492:
2153:
920:
231:
128:
78:
1953:
2180:
517:
475:
353:
298:
285:
197:
184:
86:
2559:
2500:
2465:
2416:
2367:
1822:
1151:
2349:
1769:
843:
838:
827:
662:
643:
1178:
within the taxonomic group
Arthropoda. The size of the gene family for
1036:
There are four promoters that result from TMEM169 search on
Genomatix.
629:
584:
1124:
5-8, 47-50, 57-60, 62-65, 123-26, 138-141, 142-145, 269-272, 284-287
955:
Schematic illustration of TMEM169 promoters (green) and exons (blue).
915:
The specific structure of TMEM169 is unknown, although includes both
811:
539:
866:
1095:
TMEM169 highlighting domains and post-translational modifications
2053:"Genomatix Software Suite - Scientific Analysis of genomic data"
1704:
870:
1074:
staining of the human cerebral cortex with antibody HPA074877.
2181:"Clustal Omega < Multiple Sequence Alignment < EMBL-EBI"
2284:
1930:"TMEM169 Gene - GeneCards | TM169 Protein | TM169 Antibody"
2387:
American
Journal of Respiratory and Critical Care Medicine
2260:
1977:
322:
487:
772:
739:
713:
680:
458:
dentate gyrus of hippocampal formation granule cell
2202:
2200:
1867:
1865:
1863:
1846:
1844:
1842:
1148:conserved transmembrane domains across orthologs.
269:
168:
1978:"SIB Swiss Institute of Bioinformatics | Expasy"
1189:A portion of amino acid conservation of distant
1872:GRCm38: Ensembl release 89: ENSMUSG00000026188
2026:"Phyre 2 alignment of Undefined with c5doqC_"
2002:"Phyre 2 alignment of Undefined with c5doqC_"
1954:"SAPS < Sequence Statistics < EMBL-EBI"
8:
2175:
2173:
1851:GRCh38: Ensembl release 89: ENSG00000163449
873:(peroxisomal trans-2-enoyl-CoA reductase).
2430:Yue X, Acun A, Zorlutuna P (August 2017).
1823:"BLAST: Basic Local Alignment Search Tool"
1101:
931:
513:
310:
209:
106:
2549:
2539:
2455:
2406:
2357:
869:(X-ray repair cross complementing 5) and
2285:"TimeTree :: The Timescale of Life"
2261:"TimeTree :: The Timescale of Life"
1670:
1196:
1184:
1150:
1086:
958:
950:
1740:
1711:Clinical Relevance- Disease Association
899:There are two transmembrane domains of
1182:is one and there is only one isoform.
1155:The amino acid conservation of strict
31:
2047:
2045:
1764:
1721:Chronic Obstructive Pulmonary Disease
274:
235:
230:
173:
132:
127:
7:
1924:
1922:
1920:
1817:
1815:
1813:
1762:
1760:
1758:
1756:
1754:
1752:
1750:
1748:
1746:
1744:
20:Transmembrane protein 169 (TMEM169)
769:
736:
710:
677:
653:
634:
608:
589:
563:
544:
492:
410:
348:
327:
14:
1083:Post-transalational modifications
2082:"49003965 - GEO Profiles - NCBI"
926:
258:
251:
245:
222:
157:
150:
144:
119:
1253:Thirteen-lined ground squirrel
1717:single nucleotide polymorphism
476:More reference expression data
23:related homolog of TMEM169 is
1:
1675:Rate of Divergence of TMEM169
243:
142:
2448:10.1016/j.actbio.2017.06.031
1058:GEO Profile: GDS3113/220527
2580:Genes on human chromosome 2
2338:The Journal of Cell Biology
1250:Ictidomys tridecemlineatus
1054:NCBI GEO Profile Microarray
380:stromal cell of endometrium
61:, transmembrane protein 169
2596:
2399:10.1164/rccm.200910-1586OC
2541:10.1186/s13148-015-0052-x
2493:10.1007/s00381-017-3491-1
1907:"Mouse PubMed Reference:"
1889:"Human PubMed Reference:"
1560:Drosophila melangogaster
1537:Saccoglossus kowalevskii
1496:Crown of thorns starfish
1320:White tailed tropic bird
1298:Chinese softshell turtle
1220:Date of Divergence (MYA)
842:
837:
833:
826:
810:
791:
776:
743:
732:
717:
684:
673:
660:
656:
641:
637:
628:
615:
611:
596:
592:
583:
570:
566:
551:
547:
538:
523:
516:
512:
500:
495:
486:
473:
422:
413:
360:
351:
321:
313:
309:
292:
279:
242:
221:
212:
208:
191:
178:
141:
118:
109:
105:
68:
65:
55:
48:
43:
39:
34:
1682:Identified orthologs of
1585:Atlantic horseshoe crab
1078:Protein Level Regulation
797:Chr 2: 216.08 – 216.1 Mb
1272:Chelonoidis abingdonii
1107:Predicted Modification
971:Supporting Transcripts
804:Chr 1: 72.32 – 72.34 Mb
2481:Child's Nervous System
1827:blast.ncbi.nlm.nih.gov
1676:
1515:Brachiostoma floridae
1430:Australian ghostshark
1361:Rhinatrema bivittatum
1275:Pinta island tortoise
1194:
1160:
1121:phosphorylation sites
1096:
1091:Conceptual Diagram of
956:
2350:10.1083/jcb.201501072
1674:
1549:
1188:
1154:
1090:
954:
939:Gene level regulation
396:cerebellar hemisphere
2528:Clinical Epigenetics
2241:www.ncbi.nlm.nih.gov
2134:www.proteinatlas.org
2106:"TMEM169 Antibodies"
2086:www.ncbi.nlm.nih.gov
2030:www.sbg.bio.ic.ac.uk
2006:www.sbg.bio.ic.ac.uk
1798:www.ncbi.nlm.nih.gov
1774:www.ncbi.nlm.nih.gov
1700:Interacting Proteins
1691:Evolutionary History
1648:Anopheles albimanus
1427:Callorhinchus milii
1364:Two-lined caecilian
1295:Pelodiscus sinensis
1113:Amino Acid Location
1024:216099253-216100292
1010:216094696-216095735
996:216094326-216095365
982:216080866-216082107
237:Chromosome 1 (mouse)
135:Chromosome 2 (human)
1725:neural tube defects
1582:Limulus polyphemus
1493:Acanthaster planci
1471:Petromyzon marinus
1386:High himalaya frog
1198:
1180:Anopheles albimanus
1174:Anopheles albimanus
1103:
1072:immunohistochemical
911:Secondary Structure
450:ganglionic eminence
446:trigeminal ganglion
368:ganglionic eminence
99:TMEM169 - orthologs
26:Anopheles albimanus
2436:Acta Biomaterialia
2212:embnet.vital-it.ch
1677:
1317:Phaethon lepturus
1197:
1195:
1161:
1102:
1097:
1040:Expression pattern
957:
618:ENSMUSG00000026188
462:supraoptic nucleus
364:buccal mucosa cell
2208:"BoxShade Server"
2110:Novus Biologicals
1934:www.genecards.org
1669:
1668:
1629:Lingula anantina
1604:Octopus vulgaris
1518:Florida lancelet
1383:Nanorana parkeri
1217:Accession Number
1166:
1140:
1139:
1136:226-231, 261-266
1031:
1030:
907:TMEM169 protein.
853:
852:
849:
848:
822:
821:
787:
786:
766:
765:
728:
727:
707:
706:
669:
668:
650:
649:
624:
623:
605:
604:
579:
578:
560:
559:
508:
507:
504:
503:
482:
481:
469:
468:
407:
406:
392:cerebellar cortex
376:prefrontal cortex
305:
304:
204:
203:
2587:
2564:
2563:
2553:
2543:
2519:
2513:
2512:
2487:(9): 1575–1581.
2476:
2470:
2469:
2459:
2427:
2421:
2420:
2410:
2378:
2372:
2371:
2361:
2329:
2323:
2322:
2320:
2319:
2305:
2299:
2298:
2296:
2295:
2289:www.timetree.org
2281:
2275:
2274:
2272:
2271:
2265:www.timetree.org
2257:
2251:
2250:
2248:
2247:
2233:
2227:
2226:
2224:
2223:
2214:. Archived from
2204:
2195:
2194:
2192:
2191:
2177:
2168:
2167:
2165:
2164:
2158:myhits.sib.swiss
2150:
2144:
2143:
2141:
2140:
2126:
2120:
2119:
2117:
2116:
2102:
2096:
2095:
2093:
2092:
2078:
2072:
2071:
2069:
2068:
2059:. Archived from
2057:www.genomatix.de
2049:
2040:
2039:
2037:
2036:
2022:
2016:
2015:
2013:
2012:
1998:
1992:
1991:
1989:
1988:
1974:
1968:
1967:
1965:
1964:
1950:
1944:
1943:
1941:
1940:
1926:
1915:
1914:
1903:
1897:
1896:
1885:
1879:
1869:
1858:
1848:
1837:
1836:
1834:
1833:
1819:
1808:
1807:
1805:
1804:
1790:
1784:
1783:
1781:
1780:
1766:
1651:Mosquito strain
1626:Lingula anatina
1521:Cephalochordata
1477:Petrymyzontidae
1449:Rhincodon typus
1199:
1164:
1104:
1004:GXP_9516027 (+)
990:GXP_9516026 (+)
976:GXP_6745619 (+)
959:
935:
930:
835:
834:
806:
799:
782:
770:
761:
737:
733:RefSeq (protein)
723:
711:
702:
678:
654:
635:
609:
590:
564:
545:
514:
493:
478:
426:secondary oocyte
418:
416:Top expressed in
411:
388:ventricular zone
372:secondary oocyte
356:
354:Top expressed in
349:
328:
311:
301:
288:
277:
262:
255:
249:
238:
226:
210:
200:
187:
176:
161:
154:
148:
137:
123:
107:
101:
60:
53:
32:
2595:
2594:
2590:
2589:
2588:
2586:
2585:
2584:
2570:
2569:
2568:
2567:
2521:
2520:
2516:
2478:
2477:
2473:
2429:
2428:
2424:
2380:
2379:
2375:
2331:
2330:
2326:
2317:
2315:
2309:"PSICQUIC View"
2307:
2306:
2302:
2293:
2291:
2283:
2282:
2278:
2269:
2267:
2259:
2258:
2254:
2245:
2243:
2235:
2234:
2230:
2221:
2219:
2206:
2205:
2198:
2189:
2187:
2179:
2178:
2171:
2162:
2160:
2152:
2151:
2147:
2138:
2136:
2128:
2127:
2123:
2114:
2112:
2104:
2103:
2099:
2090:
2088:
2080:
2079:
2075:
2066:
2064:
2051:
2050:
2043:
2034:
2032:
2024:
2023:
2019:
2010:
2008:
2000:
1999:
1995:
1986:
1984:
1976:
1975:
1971:
1962:
1960:
1952:
1951:
1947:
1938:
1936:
1928:
1927:
1918:
1905:
1904:
1900:
1887:
1886:
1882:
1870:
1861:
1849:
1840:
1831:
1829:
1821:
1820:
1811:
1802:
1800:
1792:
1791:
1787:
1778:
1776:
1768:
1767:
1742:
1737:
1713:
1702:
1693:
1455:Chondrichthyes
1433:Chondrichthyes
1411:Actinopterygii
1213:Taxonomic group
1203:Scientific Name
1168:
1145:
1119:Casein Kinase 2
1085:
1080:
1067:
1056:
1047:
1042:
1018:GXP_142640 (+)
946:
941:
913:
897:
888:
879:
863:
858:
844:View/Edit Mouse
839:View/Edit Human
802:
795:
792:Location (UCSC)
778:
757:
753:
749:
745:
719:
698:
694:
690:
686:
599:ENSG00000163449
474:
465:
460:
456:
452:
448:
444:
440:
436:
434:proximal tubule
432:
428:
414:
403:
398:
394:
390:
386:
384:Brodmann area 9
382:
378:
374:
370:
366:
352:
296:
283:
275:
265:
264:
263:
256:
236:
213:Gene location (
195:
182:
174:
164:
163:
162:
155:
133:
110:Gene location (
69:
56:
49:
17:
12:
11:
5:
2593:
2591:
2583:
2582:
2572:
2571:
2566:
2565:
2514:
2471:
2422:
2373:
2324:
2300:
2276:
2252:
2228:
2196:
2169:
2145:
2121:
2097:
2073:
2041:
2017:
1993:
1982:www.expasy.org
1969:
1945:
1916:
1898:
1880:
1859:
1838:
1809:
1785:
1739:
1738:
1736:
1733:
1712:
1709:
1701:
1698:
1692:
1689:
1667:
1666:
1663:
1660:
1658:XP_035794912.1
1655:
1652:
1649:
1645:
1644:
1641:
1638:
1636:XP_013413871.1
1633:
1630:
1627:
1623:
1622:
1619:
1616:
1614:XP_029635540.1
1611:
1608:
1605:
1601:
1600:
1597:
1594:
1589:
1586:
1583:
1579:
1578:
1575:
1572:
1567:
1564:
1561:
1557:
1556:
1553:
1550:
1544:
1541:
1538:
1534:
1533:
1530:
1527:
1525:XP_035657488.1
1522:
1519:
1516:
1512:
1511:
1508:
1505:
1503:XP_022081757.1
1500:
1499:Echinodermata
1497:
1494:
1490:
1489:
1486:
1483:
1481:XP_032801904.1
1478:
1475:
1472:
1468:
1467:
1464:
1461:
1459:XP_020389226.1
1456:
1453:
1450:
1446:
1445:
1442:
1439:
1437:XP_007908296.1
1434:
1431:
1428:
1424:
1423:
1420:
1417:
1415:NP_001313389.1
1412:
1409:
1406:
1402:
1401:
1398:
1395:
1393:XP_018409958.1
1390:
1387:
1384:
1380:
1379:
1376:
1373:
1371:XP_029460980.1
1368:
1365:
1362:
1358:
1357:
1354:
1351:
1349:XP_015145533.1
1346:
1343:
1340:
1339:Gallus gallus
1336:
1335:
1332:
1329:
1327:XP_010279821.1
1324:
1321:
1318:
1314:
1313:
1310:
1307:
1302:
1299:
1296:
1292:
1291:
1288:
1285:
1279:
1276:
1273:
1269:
1268:
1265:
1262:
1260:XP_005331895.1
1257:
1254:
1251:
1247:
1246:
1243:
1240:
1238:NP_001135782.1
1235:
1232:
1229:
1225:
1224:
1221:
1218:
1215:
1210:
1205:
1167:
1162:
1144:
1141:
1138:
1137:
1134:
1131:myristoylation
1126:
1125:
1122:
1115:
1114:
1108:
1084:
1081:
1079:
1076:
1066:
1063:
1055:
1052:
1046:
1045:RNA sequencing
1043:
1041:
1038:
1029:
1028:
1025:
1022:
1019:
1015:
1014:
1013:Computational
1011:
1008:
1005:
1001:
1000:
999:Computational
997:
994:
991:
987:
986:
983:
980:
977:
973:
972:
969:
966:
963:
945:
942:
940:
937:
912:
909:
896:
893:
887:
884:
878:
875:
862:
859:
857:
854:
851:
850:
847:
846:
841:
831:
830:
824:
823:
820:
819:
817:
815:
808:
807:
800:
793:
789:
788:
785:
784:
774:
773:
767:
764:
763:
741:
740:
734:
730:
729:
726:
725:
715:
714:
708:
705:
704:
682:
681:
675:
671:
670:
667:
666:
658:
657:
651:
648:
647:
639:
638:
632:
626:
625:
622:
621:
613:
612:
606:
603:
602:
594:
593:
587:
581:
580:
577:
576:
568:
567:
561:
558:
557:
549:
548:
542:
536:
535:
530:
525:
521:
520:
510:
509:
506:
505:
502:
501:
498:
497:
490:
484:
483:
480:
479:
471:
470:
467:
466:
464:
463:
459:
455:
451:
447:
443:
439:
438:primary oocyte
435:
431:
427:
423:
420:
419:
408:
405:
404:
402:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
358:
357:
345:
344:
336:
325:
319:
318:
315:RNA expression
307:
306:
303:
302:
294:
290:
289:
281:
278:
273:
267:
266:
257:
250:
244:
240:
239:
234:
228:
227:
219:
218:
206:
205:
202:
201:
193:
189:
188:
180:
177:
172:
166:
165:
156:
149:
143:
139:
138:
131:
125:
124:
116:
115:
103:
102:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
15:
13:
10:
9:
6:
4:
3:
2:
2592:
2581:
2578:
2577:
2575:
2561:
2557:
2552:
2547:
2542:
2537:
2533:
2529:
2525:
2518:
2515:
2510:
2506:
2502:
2498:
2494:
2490:
2486:
2482:
2475:
2472:
2467:
2463:
2458:
2453:
2449:
2445:
2441:
2437:
2433:
2426:
2423:
2418:
2414:
2409:
2404:
2400:
2396:
2393:(5): 605–13.
2392:
2388:
2384:
2377:
2374:
2369:
2365:
2360:
2355:
2351:
2347:
2344:(4): 863–79.
2343:
2339:
2335:
2328:
2325:
2314:
2313:www.ebi.ac.uk
2310:
2304:
2301:
2290:
2286:
2280:
2277:
2266:
2262:
2256:
2253:
2242:
2238:
2232:
2229:
2218:on 2020-10-29
2217:
2213:
2209:
2203:
2201:
2197:
2186:
2185:www.ebi.ac.uk
2182:
2176:
2174:
2170:
2159:
2155:
2149:
2146:
2135:
2131:
2125:
2122:
2111:
2107:
2101:
2098:
2087:
2083:
2077:
2074:
2063:on 2012-01-14
2062:
2058:
2054:
2048:
2046:
2042:
2031:
2027:
2021:
2018:
2007:
2003:
1997:
1994:
1983:
1979:
1973:
1970:
1959:
1958:www.ebi.ac.uk
1955:
1949:
1946:
1935:
1931:
1925:
1923:
1921:
1917:
1912:
1908:
1902:
1899:
1894:
1890:
1884:
1881:
1877:
1873:
1868:
1866:
1864:
1860:
1856:
1852:
1847:
1845:
1843:
1839:
1828:
1824:
1818:
1816:
1814:
1810:
1799:
1795:
1789:
1786:
1775:
1771:
1765:
1763:
1761:
1759:
1757:
1755:
1753:
1751:
1749:
1747:
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1741:
1734:
1732:
1730:
1726:
1722:
1718:
1710:
1708:
1706:
1699:
1697:
1690:
1688:
1685:
1681:
1673:
1664:
1661:
1659:
1656:
1653:
1650:
1647:
1646:
1642:
1639:
1637:
1634:
1631:
1628:
1625:
1624:
1620:
1617:
1615:
1612:
1609:
1606:
1603:
1602:
1598:
1595:
1593:
1590:
1587:
1584:
1581:
1580:
1576:
1573:
1571:
1568:
1565:
1562:
1559:
1558:
1554:
1551:
1548:
1545:
1543:Hemichordata
1542:
1539:
1536:
1535:
1531:
1528:
1526:
1523:
1520:
1517:
1514:
1513:
1509:
1506:
1504:
1501:
1498:
1495:
1492:
1491:
1487:
1484:
1482:
1479:
1476:
1473:
1470:
1469:
1465:
1462:
1460:
1457:
1454:
1451:
1448:
1447:
1443:
1440:
1438:
1435:
1432:
1429:
1426:
1425:
1421:
1418:
1416:
1413:
1410:
1407:
1404:
1403:
1399:
1396:
1394:
1391:
1388:
1385:
1382:
1381:
1377:
1374:
1372:
1369:
1366:
1363:
1360:
1359:
1355:
1352:
1350:
1347:
1344:
1341:
1338:
1337:
1333:
1330:
1328:
1325:
1322:
1319:
1316:
1315:
1311:
1308:
1306:
1303:
1300:
1297:
1294:
1293:
1289:
1286:
1283:
1280:
1277:
1274:
1271:
1270:
1266:
1263:
1261:
1258:
1255:
1252:
1249:
1248:
1244:
1241:
1239:
1236:
1233:
1230:
1228:Homo sapiens
1227:
1226:
1222:
1219:
1216:
1214:
1211:
1209:
1206:
1204:
1201:
1200:
1192:
1187:
1183:
1181:
1177:
1175:
1163:
1158:
1153:
1149:
1142:
1135:
1132:
1128:
1127:
1123:
1120:
1117:
1116:
1112:
1109:
1106:
1105:
1100:
1094:
1089:
1082:
1077:
1075:
1073:
1064:
1062:
1059:
1053:
1051:
1044:
1039:
1037:
1035:
1026:
1023:
1020:
1017:
1016:
1012:
1009:
1006:
1003:
1002:
998:
995:
992:
989:
988:
984:
981:
978:
975:
974:
970:
967:
964:
961:
960:
953:
949:
943:
938:
936:
934:
929:
924:
922:
918:
917:alpha helices
910:
908:
906:
902:
894:
892:
885:
883:
876:
874:
872:
868:
860:
855:
845:
840:
836:
832:
829:
825:
818:
816:
813:
809:
805:
801:
798:
794:
790:
783:
781:
775:
771:
768:
762:
760:
756:
752:
748:
742:
738:
735:
731:
724:
722:
716:
712:
709:
703:
701:
697:
693:
689:
683:
679:
676:
674:RefSeq (mRNA)
672:
665:
664:
659:
655:
652:
646:
645:
640:
636:
633:
631:
627:
620:
619:
614:
610:
607:
601:
600:
595:
591:
588:
586:
582:
575:
574:
569:
565:
562:
556:
555:
550:
546:
543:
541:
537:
534:
531:
529:
526:
522:
519:
515:
511:
499:
494:
491:
489:
485:
477:
472:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
424:
421:
417:
412:
409:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
362:
359:
355:
350:
347:
346:
343:
341:
337:
335:
334:
330:
329:
326:
324:
320:
316:
312:
308:
300:
295:
291:
287:
282:
272:
268:
261:
254:
248:
241:
233:
229:
225:
220:
216:
211:
207:
199:
194:
190:
186:
181:
171:
167:
160:
153:
147:
140:
136:
130:
126:
122:
117:
113:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
29:
27:
21:
2531:
2527:
2517:
2484:
2480:
2474:
2439:
2435:
2425:
2390:
2386:
2376:
2341:
2337:
2327:
2316:. Retrieved
2312:
2303:
2292:. Retrieved
2288:
2279:
2268:. Retrieved
2264:
2255:
2244:. Retrieved
2240:
2231:
2220:. Retrieved
2216:the original
2211:
2188:. Retrieved
2184:
2161:. Retrieved
2157:
2154:"Motif Scan"
2148:
2137:. Retrieved
2133:
2124:
2113:. Retrieved
2109:
2100:
2089:. Retrieved
2085:
2076:
2065:. Retrieved
2061:the original
2056:
2033:. Retrieved
2029:
2020:
2009:. Retrieved
2005:
1996:
1985:. Retrieved
1981:
1972:
1961:. Retrieved
1957:
1948:
1937:. Retrieved
1933:
1910:
1901:
1892:
1883:
1830:. Retrieved
1826:
1801:. Retrieved
1797:
1788:
1777:. Retrieved
1773:
1729:preeclampsia
1714:
1703:
1694:
1684:Homo sapiens
1683:
1679:
1678:
1592:XP_022256315
1547:XP_002740626
1474:Sea lamprey
1452:Whale shark
1405:Danio rerio
1305:XP_006124795
1282:XP_032620330
1212:
1207:
1202:
1191:Homo sapiens
1190:
1179:
1172:
1169:
1157:Homo sapiens
1156:
1146:
1111:Homo Sapiens
1110:
1098:
1093:Homo sapiens
1092:
1068:
1060:
1057:
1048:
1033:
1032:
968:Coordinates
947:
925:
914:
905:Homo sapiens
904:
901:Homo sapiens
900:
898:
889:
882:four exons.
880:
864:
777:
755:NP_001135784
751:NP_001135783
747:NP_001135782
744:
718:
696:NM_001142312
692:NM_001142311
688:NM_001142310
685:
661:
642:
616:
597:
571:
552:
532:
527:
442:right kidney
338:
331:
196:216,102,783
183:216,081,866
66:External IDs
24:
19:
18:
2442:: 337–348.
1654:Arthropoda
1588:Arthropoda
1570:NP_650031.1
1566:Arthropoda
1540:Acorn worm
1223:% identity
1208:Common name
921:beta sheets
877:Transcripts
454:neural tube
297:72,342,263
284:72,323,528
276:1|1 C3
44:Identifiers
2318:2020-12-16
2294:2020-10-22
2270:2020-10-29
2246:2020-10-22
2222:2020-10-29
2190:2020-10-29
2163:2020-12-16
2139:2020-12-07
2115:2020-12-07
2091:2020-12-07
2067:2020-12-07
2035:2020-12-16
2011:2020-12-18
1987:2020-12-16
1963:2020-12-16
1939:2020-09-29
1878:, May 2017
1857:, May 2017
1832:2020-10-22
1803:2020-09-29
1779:2020-09-29
1735:References
1563:Fruit fly
1408:Zebrafish
1065:Antibodies
342:(ortholog)
79:HomoloGene
2534:(1): 21.
1632:Mollusca
1610:Mollusca
1389:Amphibia
1367:Amphibia
1301:Reptilia
1278:Reptilla
1256:Mammalia
1234:Mammalia
1165:Orthologs
962:Promoter
780:NP_780773
759:NP_612399
721:NM_175564
700:NM_138390
518:Orthologs
87:GeneCards
2574:Category
2560:25806090
2509:25442338
2501:28721594
2466:28648749
2417:20463177
2368:26598620
1874:–
1853:–
1680:Table 1.
1607:Octopus
1342:Chicken
1143:Homology
1034:Table 2.
1021:1040 bp
1007:1040 bp
993:1040 bp
979:1242 bp
944:Promoter
828:Wikidata
2551:4371797
2457:5563470
2408:2937234
2359:4657161
1876:Ensembl
1855:Ensembl
1284:
895:Domains
886:Protein
630:UniProt
585:Ensembl
524:Species
317:pattern
91:TMEM169
75:2442781
58:TMEM169
51:Aliases
35:TMEM169
2558:
2548:
2507:
2499:
2464:
2454:
2415:
2405:
2366:
2356:
1231:Human
814:search
812:PubMed
663:Q8BG50
644:Q96HH4
573:271711
540:Entrez
488:BioGPS
430:zygote
2505:S2CID
1345:Aves
1323:Aves
1133:site
965:Size
867:XRCC5
861:Locus
554:92691
533:Mouse
528:Human
400:gonad
340:Mouse
333:Human
280:Start
215:Mouse
179:Start
112:Human
83:16305
2556:PMID
2497:PMID
2462:PMID
2413:PMID
2364:PMID
1727:and
1705:RhoU
1662:797
1640:797
1618:797
1596:797
1574:797
1552:684
1529:684
1507:627
1485:615
1463:473
1441:473
1419:435
1397:353
1375:352
1353:318
1331:312
1309:312
1287:312
1245:100
919:and
871:PECR
856:Gene
323:Bgee
271:Band
232:Chr.
175:2q35
170:Band
129:Chr.
16:Gene
2546:PMC
2536:doi
2489:doi
2452:PMC
2444:doi
2403:PMC
2395:doi
2391:182
2354:PMC
2346:doi
2342:211
1665:38
1643:39
1621:41
1599:51
1577:45
1555:45
1532:54
1510:40
1488:51
1466:60
1444:64
1422:50
1400:65
1378:66
1356:66
1334:67
1312:68
1290:69
1267:90
1264:90
985:11
496:n/a
293:End
192:End
95:OMA
71:MGI
2576::
2554:.
2544:.
2530:.
2526:.
2503:.
2495:.
2485:33
2483:.
2460:.
2450:.
2440:58
2438:.
2434:.
2411:.
2401:.
2389:.
2385:.
2362:.
2352:.
2340:.
2336:.
2311:.
2287:.
2263:.
2239:.
2210:.
2199:^
2183:.
2172:^
2156:.
2132:.
2108:.
2084:.
2055:.
2044:^
2028:.
2004:.
1980:.
1956:.
1932:.
1919:^
1909:.
1891:.
1862:^
1841:^
1825:.
1812:^
1796:.
1772:.
1743:^
1715:A
1242:0
1129:N-
1027:1
923:.
299:bp
286:bp
198:bp
185:bp
93:;
89::
85:;
81::
77:;
73::
2562:.
2538::
2532:7
2511:.
2491::
2468:.
2446::
2419:.
2397::
2370:.
2348::
2321:.
2297:.
2273:.
2249:.
2225:.
2193:.
2166:.
2142:.
2118:.
2094:.
2070:.
2038:.
2014:.
1990:.
1966:.
1942:.
1913:.
1895:.
1835:.
1806:.
1782:.
1176:,
217:)
114:)
97::
28:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
