292:, giving rise to names p23, p24, et al. As further family members were discovered, they were given names that fit the pattern – p26, p27, and p28 – even though they too were around 24 kilodaltons. In 1998, a more systematic nomenclature was proposed with all proteins called "p24", the Greek letter for their sub-family, and then numbered in the order of their discovery.
203:, where they seem to be involved in trafficking between the two compartments. In yeast, all p24 family proteins can be removed, causing only a mild phenotype. However, in mammals at least some p24 proteins are essential for survival, e.g. removal of p24δ1 is lethal in mice. p24 family members have been implicated in the biogenesis of
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Vertebrates have three α family members: p24α1 (Erp1p in yeast), p24α2 (Erp5p), and p24α3 (Erp6p); one β member p24β1 (Emp24p in yeast); five γ members: p24γ1, p24γ2 (Erp2p in yeast), p24γ3 (Erp3p), p24γ4 (Erp4p), and p24γ5; and two δ members: p24δ1 (Erv25p in yeast) and p24δ2.
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p24 family proteins are divided based on their sequence into four families: called α, β, γ, and δ. Most vertebrates have three α family members, one β, five γ, and two δ; while yeast have three α, a β, three γ, and one δ. Plants have only the β and δ subfamilies.
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Pastor-Cantizano N, Montesinos JC, Bernat-Silvestre C, Marcote MJ, Aniento F (July 2016). "p24 family proteins: key players in the regulation of trafficking along the secretory pathway".
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domain involved in the oligomerization of p24 family members. The cytosolic tail is involved in binding COPI and COPII proteins for sorting into vesicles within the secretory system.
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211:-coated vesicles, transporting membrane-bound proteins through the secretory system, and forming the structure of the endoplasmic reticulum and Golgi.
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with a single transmembrane domain. Most of the protein is in the lumen of the endoplasmic reticulum or Golgi save for a 13–20
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p24 proteins were originally named based on their apparently molecular weight of around 24
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ynamics") which may be involved in cargo recognition, followed by a
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is a group of transmembrane proteins that are major components of
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peptide, which is implicated in the pathogenesis of
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223:in various tissues. They are highly expressed in
169:transmembrane emp24 domain-containing protein 10
159:-coated vesicles. The family is also known as
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191:p24 family proteins localize to the major
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250:. The N-terminus has a GOLD domain (for "
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219:Most p24 family proteins are widely
195:of the early secretory pathway: the
386:Single-pass transmembrane proteins
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175:. It was claimed to block the
167:. The latter naming was after
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237:type 1 transmembrane proteins
88:Available protein structures:
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350:10.1007/s00709-015-0858-6
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235:p24 family proteins are
246:tail at the protein's
171:that was found in the
161:EMP24/GP25L/p24 family
197:endoplasmic reticulum
181:Alzheimer's disease
165:TMP21-like proteins
149:P24 protein family
30:P24 protein family
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137:structure summary
16:(Redirected from
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201:Golgi apparatus
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215:Distribution
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177:beta-amyloid
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338:Protoplasma
290:kilodaltons
260:coiled coil
173:human brain
35:Identifiers
296:References
248:C-terminus
241:amino acid
193:organelles
100:structures
73:Membranome
366:254088111
266:Evolution
244:cytosolic
231:Structure
221:expressed
66:IPR015720
380:Category
358:26224213
199:and the
187:Function
117:RCSB PDB
61:InterPro
284:History
227:types.
54:PF01105
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132:PDBsum
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40:Symbol
362:S2CID
209:COPII
157:COPII
43:TMP21
18:TMED6
354:PMID
207:and
205:COPI
163:and
155:and
153:COPI
125:PDBj
121:PDBe
104:ECOD
94:Pfam
49:Pfam
346:doi
342:253
254:gi
252:Gol
183:.
112:PDB
78:140
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304:^
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102:/
368:.
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256:D
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