358:
335:
232:
257:
616:
609:
29:
364:
263:
55:
2452:
Zheng C, Huang Y, Ye Z, Wang Y, Tang Z, Lu J, Wu J, Zhou Y, Wang L, Huang Z, Yang H, Xue A (2018) Infantile onset intractable inflammatory bowel disease due to novel heterozygous mutations in TNFAIP3 (A20). Inflamm Bowel Dis doi: 10.1093/ibd/izy165
2823:"The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN"
1963:"The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN"
1510:), TNFAIP3 has been shown to be critical for limiting inflammation by terminating endotoxin- and TNF-induced NF-kappa B responses. In brief, deubiquitinase function of TNFAIP3 was shown to remove ubiquitin chains from
1582:
increase risk of RA by 20 to 40% respectively. A third SNP, rs10499194 (T) is found less often in rheumatoid arthritis but this negative association may not be statistically meaningful.
2993:
Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions".
2304:
De Valck, D; Heyninck K; Van
Criekinge W; Vandenabeele P; Fiers W; Beyaert R (September 1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins".
3108:
Baltathakis I, Alcantara O, Boldt DH (2001). "Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling".
371:
270:
3145:
Zetoune FS, Murthy AR, Shao Z, et al. (2002). "A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome".
3254:"A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells"
2737:"Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2"
1174:
1155:
193:
1478:
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a
2706:
De Valck D, Heyninck K, Van
Criekinge W, et al. (1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins".
1679:
1661:
3336:
2669:
De Valck D, Heyninck K, Van
Criekinge W, et al. (1996). "A20, an inhibitor of cell death, self-associates by its zinc finger domain".
357:
1398:
1405:
334:
2470:"Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin"
1738:
1648:
1627:
1579:
1754:"Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions"
1644:
2909:"Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation"
2151:"Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation"
256:
231:
52:
2583:"The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation"
2023:"The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation"
1623:
173:
2636:"14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules"
2254:"14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules"
370:
269:
1527:
1961:
Heyninck, K; De Valck D; Vanden Berghe W; Van
Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R (June 1999).
363:
262:
2874:"The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases"
2780:"The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6"
2200:"The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases"
2094:"The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6"
1599:
1219:
181:
2540:"A20 Ameliorates Intracerebral Hemorrhage-Induced Inflammatory Injury by Regulating TRAF6 Polyubiquitination"
1483:
1200:
2198:
De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R (July 1999).
3211:"Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury"
2955:
2594:
2035:
1865:"Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury"
1816:
1575:
245:
160:
3032:"Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2"
1590:
An association with infantile onset intractable inflammatory bowel disease has also been reported.
1479:
1377:
1352:
1348:
1318:
1293:
1289:
3133:
3018:
2809:
2694:
2406:"Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci"
2131:
1699:"The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein"
205:
1381:
1356:
1322:
1297:
615:
608:
975:
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
870:
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
3303:
3283:
3240:
3197:
3162:
3125:
3096:
3053:
3010:
2981:
2930:
2895:
2860:
2801:
2766:
2723:
2686:
2657:
2622:
2569:
2526:
2491:
2435:
2386:
2368:
2329:
2321:
2283:
2275:
2229:
2221:
2180:
2172:
2123:
2115:
2071:
2053:
2000:
1982:
1943:
1894:
1842:
1785:
1720:
1515:
153:
45:
201:
3273:
3265:
3230:
3222:
3187:
3154:
3117:
3086:
3078:
3043:
3002:
2971:
2963:
2920:
2885:
2850:
2842:
2834:
2791:
2756:
2748:
2715:
2678:
2647:
2612:
2602:
2559:
2551:
2516:
2481:
2425:
2417:
2376:
2360:
2313:
2265:
2211:
2162:
2105:
2061:
2043:
1990:
1974:
1933:
1925:
1884:
1876:
1832:
1824:
1775:
1765:
1710:
1506:
composition. Using knockout mouse models of TNFAIP3 and its transcriptional repressor (i.e.
450:
381:
325:
280:
2944:"Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice"
1805:"Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice"
425:
28:
2959:
2598:
2039:
1820:
3235:
3210:
3091:
3066:
2976:
2943:
2855:
2822:
2564:
2539:
2430:
2405:
2381:
2348:
1995:
1962:
1938:
1913:
1889:
1864:
1837:
1804:
1780:
1753:
1503:
955:
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
3278:
3253:
3006:
2925:
2908:
2796:
2779:
2761:
2736:
2486:
2469:
2347:
Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J (August 2001).
2167:
2150:
2110:
2093:
1715:
1698:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
788:
783:
778:
773:
768:
763:
747:
742:
737:
732:
727:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
3330:
3312:
3269:
2682:
2617:
2582:
2066:
2022:
644:
3209:
Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018).
3137:
3022:
2813:
2752:
2698:
2135:
1863:
Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018).
185:
443:
222:
2967:
1828:
1752:
Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. (2018).
860:
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
209:
3082:
2505:"A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism"
2364:
1803:
Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma A (September 2000).
1684:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1666:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1511:
850:
negative regulation of cyclin-dependent protein serine/threonine kinase activity
526:
3226:
1880:
1487:
342:
239:
189:
2652:
2635:
2555:
2521:
2504:
2372:
2325:
2279:
2270:
2253:
2225:
2176:
2119:
2057:
1986:
1770:
2607:
2048:
1491:
1119:
586:
464:
409:
396:
308:
295:
197:
3287:
3244:
3201:
3192:
3175:
3166:
3158:
3129:
3100:
3057:
3048:
3031:
3014:
2985:
2934:
2899:
2890:
2873:
2864:
2838:
2719:
2573:
2439:
2390:
2317:
2233:
2216:
2199:
2184:
2004:
1978:
1947:
1898:
1846:
1789:
2846:
2805:
2770:
2727:
2690:
2661:
2626:
2530:
2495:
2333:
2287:
2127:
2075:
1724:
1445:
1440:
3176:"The promyelocytic leukemia protein represses A20-mediated transcription"
1499:
1429:
1264:
1245:
1914:"The transcription factor DREAM represses A20 and mediates inflammation"
722:
3317:
3307:
1547:
1495:
1465:
1231:
1186:
1035:
nucleotide-binding oligomerization domain containing signaling pathway
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
3121:
1739:"Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3"
1574:
The TNFAIP3 locus is implicated as a positively associated factor in
1507:
1413:
1141:
1929:
2421:
1563:
1559:
1555:
1551:
1543:
1539:
1535:
1531:
164:, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
1104:
1100:
2027:
1472:
177:
3067:"Isolation and characterization of two novel A20-like proteins"
2404:
Stahl EA, Raychaudhuri S, Remmers EF, et al. (June 2010).
2349:"Isolation and characterization of two novel A20-like proteins"
2149:
Zhang, S Q; Kovalenko A; Cantarella G; Wallach D (March 2000).
708:
K63-linked polyubiquitin modification-dependent protein binding
624:
1015:
negative regulation of NF-kappaB transcription factor activity
875:
regulation of tumor necrosis factor-mediated signaling pathway
2821:
Heyninck K, De Valck D, Vanden Berghe W, et al. (1999).
1045:
negative regulation of toll-like receptor 4 signaling pathway
1030:
negative regulation of toll-like receptor 3 signaling pathway
890:
negative regulation of toll-like receptor 5 signaling pathway
865:
negative regulation of toll-like receptor 2 signaling pathway
3302:
Overview of all the structural information available in the
2735:
Eliopoulos AG, Blake SM, Floettmann JE, et al. (1999).
915:
negative regulation of I-kappaB kinase/NF-kappaB signaling
1912:
Tiruppathi C, Soni D, Wang DM, et al. (March 2014).
815:
negative regulation of endothelial cell apoptotic process
3030:
Van Huffel S, Delaei F, Heyninck K, et al. (2001).
433:
3316:(Tumor necrosis factor alpha-induced protein 3) at the
2907:
Zhang SQ, Kovalenko A, Cantarella G, Wallach D (2000).
990:
negative regulation of tumor necrosis factor production
825:
negative regulation of smooth muscle cell proliferation
2503:
Cooper JT, Stroka DM, Brostjan C, et al. (1996).
3065:
Evans PC, Taylor ER, Coadwell J, et al. (2001).
598:
2872:
De Valck D, Jin DY, Heyninck K, et al. (1999).
1697:
Opipari AW Jr; Boguski MS; Dixit VM (October 1990).
905:
negative regulation of chronic inflammatory response
820:
negative regulation of interleukin-1 beta production
1370:
1341:
1311:
1282:
995:
negative regulation of type I interferon production
1640:
1638:
1636:
1619:
1617:
1615:
1514:to prevent loss of VE-cadherin at the endothelial
380:
279:
2468:Dixit VM, Green S, Sarma V, et al. (1990).
925:establishment of protein localization to vacuole
845:positive regulation of protein catabolic process
1502:(corals, jellyfish, anemones) with a conserved
1020:negative regulation of interleukin-2 production
985:negative regulation of osteoclast proliferation
880:negative regulation of interleukin-6 production
855:regulation of defense response to virus by host
810:positive regulation of hepatocyte proliferation
16:Protein-coding gene in the species Homo sapiens
2942:Lee EG, Boone DL, Chai S, et al. (2000).
2299:
2297:
2247:
2245:
2243:
2087:
2085:
2016:
2014:
1645:GRCm38: Ensembl release 89: ENSMUSG00000019850
1578:(RA). The rs5029937 (T) and the rs6920220 (A)
1458:Tumor necrosis factor, alpha-induced protein 3
2021:Song, H Y; Rothe M; Goeddel D V (June 1996).
980:negative regulation of innate immune response
950:negative regulation of CD40 signaling pathway
935:negative regulation of protein ubiquitination
8:
2538:Meng Z, Zhao T, Zhou K, et al. (2017).
1080:positive regulation of Wnt signaling pathway
1025:negative regulation of inflammatory response
1858:
1856:
1624:GRCh38: Ensembl release 89: ENSG00000118503
1494:. The A20 protein is ancient, and protein
1115:
640:
421:
320:
217:
63:
3277:
3234:
3191:
3090:
3047:
2975:
2924:
2889:
2854:
2795:
2760:
2651:
2616:
2606:
2563:
2520:
2485:
2429:
2380:
2269:
2215:
2166:
2109:
2065:
2047:
1994:
1937:
1888:
1836:
1779:
1769:
1714:
895:tolerance induction to lipopolysaccharide
1010:response to molecule of bacterial origin
885:negative regulation of B cell activation
789:intracellular membrane-bounded organelle
2092:Heyninck, K; Beyaert R (January 1999).
1611:
1040:cellular response to lipopolysaccharide
805:regulation of germinal center formation
1055:cellular response to hydrogen peroxide
1050:negative regulation of bone resorption
743:Lys63-specific deubiquitinase activity
678:ubiquitin-protein transferase activity
18:
2581:Song HY, Rothe M, Goeddel DV (1996).
2252:Vincenz, C; Dixit V M (August 1996).
1570:Association with rheumatoid arthritis
385:
346:
341:
284:
243:
238:
7:
830:regulation of vascular wound healing
1490:activation as well as TNF-mediated
1090:protein K33-linked deubiquitination
1085:protein K29-linked deubiquitination
970:regulation of inflammatory response
965:protein K11-linked deubiquitination
945:protein K63-linked deubiquitination
840:protein K48-linked deubiquitination
1367:
1338:
1308:
1279:
1255:
1236:
1210:
1191:
1165:
1146:
603:
521:
459:
438:
14:
1468:that in humans is encoded by the
940:protein K48-linked ubiquitination
910:negative regulation of cell death
3270:10.1128/MCB.22.17.6034-6045.2002
1486:, and has been shown to inhibit
663:cysteine-type peptidase activity
614:
607:
369:
362:
356:
333:
268:
261:
255:
230:
27:
3174:Wu WS, Xu ZX, Chang KS (2002).
2753:10.1128/JVI.73.2.1023-1035.1999
2264:(33). UNITED STATES: 20029–34.
960:protein complex oligomerization
2778:Heyninck K, Beyaert R (1999).
728:thiol-dependent deubiquitinase
625:More reference expression data
587:More reference expression data
1:
3007:10.1016/S0014-5793(01)02504-2
2968:10.1126/science.289.5488.2350
2926:10.1016/S1074-7613(00)80183-1
2797:10.1016/S0014-5793(98)01645-7
2708:Biochem. Biophys. Res. Commun
2487:10.1016/S0021-9258(19)39896-5
2306:Biochem. Biophys. Res. Commun
2168:10.1016/S1074-7613(00)80183-1
2111:10.1016/S0014-5793(98)01645-7
2034:(13). UNITED STATES: 6721–5.
2028:Proc. Natl. Acad. Sci. U.S.A.
1973:(7). UNITED STATES: 1471–82.
1829:10.1126/science.289.5488.2350
1716:10.1016/S0021-9258(18)77165-2
900:response to muramyl dipeptide
354:
253:
2683:10.1016/0014-5793(96)00283-9
2634:Vincenz C, Dixit VM (1996).
2587:Proc. Natl. Acad. Sci. U.S.A
2161:(3). UNITED STATES: 301–11.
2104:(2–3). NETHERLANDS: 147–50.
1498:can be found as far back as
3337:Genes on human chromosome 6
2312:(2). UNITED STATES: 590–4.
3353:
1526:TNFAIP3 has been shown to
541:retinal pigment epithelium
3227:10.1038/s41420-018-0056-3
3083:10.1042/0264-6021:3570617
2365:10.1042/0264-6021:3570617
2359:(Pt 3). England: 617–23.
1881:10.1038/s41420-018-0056-3
1680:"Mouse PubMed Reference:"
1662:"Human PubMed Reference:"
1600:Haploinsufficiency of A20
1444:
1439:
1435:
1428:
1412:
1399:Chr 6: 137.87 – 137.88 Mb
1393:
1374:
1345:
1334:
1315:
1286:
1275:
1262:
1258:
1243:
1239:
1230:
1217:
1213:
1198:
1194:
1185:
1172:
1168:
1153:
1149:
1140:
1125:
1118:
1114:
1098:
1070:cytoskeleton organization
738:identical protein binding
643:
639:
622:
606:
597:
584:
533:
524:
495:mucosa of urinary bladder
487:epithelium of nasopharynx
479:mucosa of paranasal sinus
471:
462:
432:
424:
420:
403:
390:
353:
332:
323:
319:
302:
289:
252:
229:
220:
216:
171:
168:
158:
151:
146:
71:
66:
49:
44:
39:
35:
26:
21:
2653:10.1074/jbc.271.33.20029
2556:10.4049/jimmunol.1600334
2522:10.1074/jbc.271.30.18068
2271:10.1074/jbc.271.33.20029
2210:(29). ENGLAND: 4182–90.
1771:10.3389/fimmu.2018.01136
1406:Chr 10: 18.88 – 18.89 Mb
930:protein deubiquitination
688:protein self-association
3252:He KL, Ting AT (2002).
2608:10.1073/pnas.93.13.6721
2049:10.1073/pnas.93.13.6721
1758:Frontiers in Immunology
1484:deubiquitinating enzyme
3193:10.1074/jbc.M201648200
3159:10.1006/cyto.2001.0921
3049:10.1074/jbc.M100048200
2891:10.1038/sj.onc.1202787
2839:10.1083/jcb.145.7.1471
2720:10.1006/bbrc.1997.7343
2318:10.1006/bbrc.1997.7343
2217:10.1038/sj.onc.1202787
1979:10.1083/jcb.145.7.1471
1065:protein ubiquitination
835:B-1 B cell homeostasis
545:mesenteric lymph nodes
537:neural layer of retina
1005:inflammatory response
779:extracellular exosome
573:stroma of bone marrow
387:10 A3|10 8.08 cM
348:Chromosome 10 (mouse)
3215:Cell Death Discovery
1869:Cell Death Discovery
1576:rheumatoid arthritis
748:transferase activity
246:Chromosome 6 (human)
67:List of PDB id codes
40:Available structures
2960:2000Sci...289.2350L
2599:1996PNAS...93.6721S
2040:1996PNAS...93.6721S
1821:2000Sci...289.2350L
1815:(5488): 2350–2354.
1480:zinc finger protein
210:TNFAIP3 - orthologs
1516:adherens junctions
1220:ENSMUSG00000019850
798:Biological process
757:Cellular component
733:hydrolase activity
723:catalytic activity
693:peptidase activity
651:Molecular function
553:epithelium of lens
1455:
1454:
1451:
1450:
1424:
1423:
1389:
1388:
1364:
1363:
1330:
1329:
1305:
1304:
1271:
1270:
1252:
1251:
1226:
1225:
1207:
1206:
1181:
1180:
1162:
1161:
1110:
1109:
1060:apoptotic process
713:ubiquitin binding
673:metal ion binding
635:
634:
631:
630:
593:
592:
580:
579:
518:
517:
416:
415:
315:
314:
142:
141:
138:
137:
50:Ortholog search:
3344:
3291:
3281:
3248:
3238:
3205:
3195:
3170:
3141:
3122:10.1002/jcb.1231
3110:J. Cell. Biochem
3104:
3094:
3077:(Pt 3): 617–23.
3061:
3051:
3042:(32): 30216–23.
3026:
2989:
2979:
2954:(5488): 2350–4.
2938:
2928:
2903:
2893:
2868:
2858:
2817:
2799:
2774:
2764:
2731:
2702:
2665:
2655:
2646:(33): 20029–34.
2630:
2620:
2610:
2577:
2567:
2534:
2524:
2515:(30): 18068–73.
2499:
2489:
2454:
2450:
2444:
2443:
2433:
2401:
2395:
2394:
2384:
2344:
2338:
2337:
2301:
2292:
2291:
2273:
2249:
2238:
2237:
2219:
2195:
2189:
2188:
2170:
2146:
2140:
2139:
2113:
2089:
2080:
2079:
2069:
2051:
2018:
2009:
2008:
1998:
1958:
1952:
1951:
1941:
1909:
1903:
1902:
1892:
1860:
1851:
1850:
1840:
1800:
1794:
1793:
1783:
1773:
1749:
1743:
1742:
1735:
1729:
1728:
1718:
1694:
1688:
1687:
1676:
1670:
1669:
1658:
1652:
1642:
1631:
1621:
1437:
1436:
1408:
1401:
1384:
1368:
1359:
1339:
1335:RefSeq (protein)
1325:
1309:
1300:
1280:
1256:
1237:
1211:
1192:
1166:
1147:
1116:
683:protease binding
668:zinc ion binding
641:
627:
618:
611:
604:
589:
529:
527:Top expressed in
522:
511:cartilage tissue
467:
465:Top expressed in
460:
439:
422:
412:
399:
388:
373:
366:
360:
349:
337:
321:
311:
298:
287:
272:
265:
259:
248:
234:
218:
212:
163:
156:
133:
64:
58:
37:
36:
31:
19:
3352:
3351:
3347:
3346:
3345:
3343:
3342:
3341:
3327:
3326:
3324:
3299:
3294:
3264:(17): 6034–45.
3258:Mol. Cell. Biol
3251:
3208:
3186:(35): 31734–9.
3173:
3144:
3107:
3064:
3029:
2992:
2941:
2906:
2884:(29): 4182–90.
2871:
2820:
2790:(2–3): 147–50.
2777:
2734:
2705:
2668:
2633:
2580:
2537:
2502:
2467:
2463:
2461:Further reading
2458:
2457:
2451:
2447:
2403:
2402:
2398:
2346:
2345:
2341:
2303:
2302:
2295:
2251:
2250:
2241:
2197:
2196:
2192:
2148:
2147:
2143:
2091:
2090:
2083:
2020:
2019:
2012:
1960:
1959:
1955:
1930:10.1038/ni.2823
1911:
1910:
1906:
1862:
1861:
1854:
1802:
1801:
1797:
1751:
1750:
1746:
1737:
1736:
1732:
1709:(25): 14705–8.
1696:
1695:
1691:
1678:
1677:
1673:
1660:
1659:
1655:
1643:
1634:
1622:
1613:
1608:
1596:
1588:
1572:
1524:
1446:View/Edit Mouse
1441:View/Edit Human
1404:
1397:
1394:Location (UCSC)
1380:
1376:
1355:
1351:
1347:
1321:
1317:
1296:
1292:
1288:
1201:ENSG00000118503
1094:
793:
752:
718:protein binding
698:ligase activity
623:
613:
612:
585:
576:
571:
567:
563:
559:
555:
551:
547:
543:
539:
525:
514:
509:
505:
501:
497:
493:
489:
485:
481:
477:
463:
407:
394:
386:
376:
375:
374:
367:
347:
324:Gene location (
306:
293:
285:
275:
274:
273:
266:
244:
221:Gene location (
172:
159:
152:
73:
51:
17:
12:
11:
5:
3350:
3348:
3340:
3339:
3329:
3328:
3322:
3321:
3298:
3297:External links
3295:
3293:
3292:
3249:
3206:
3171:
3142:
3105:
3062:
3027:
2990:
2939:
2904:
2869:
2847:1854/LU-113881
2833:(7): 1471–82.
2818:
2775:
2747:(2): 1023–35.
2732:
2703:
2666:
2631:
2593:(13): 6721–5.
2578:
2535:
2500:
2464:
2462:
2459:
2456:
2455:
2445:
2422:10.1038/ng.582
2396:
2339:
2293:
2239:
2190:
2141:
2081:
2010:
1953:
1924:(3): 239–247.
1904:
1852:
1795:
1744:
1730:
1689:
1671:
1653:
1632:
1610:
1609:
1607:
1604:
1603:
1602:
1595:
1592:
1587:
1586:Other diseases
1584:
1571:
1568:
1523:
1520:
1504:protein domain
1453:
1452:
1449:
1448:
1443:
1433:
1432:
1426:
1425:
1422:
1421:
1419:
1417:
1410:
1409:
1402:
1395:
1391:
1390:
1387:
1386:
1372:
1371:
1365:
1362:
1361:
1343:
1342:
1336:
1332:
1331:
1328:
1327:
1313:
1312:
1306:
1303:
1302:
1284:
1283:
1277:
1273:
1272:
1269:
1268:
1260:
1259:
1253:
1250:
1249:
1241:
1240:
1234:
1228:
1227:
1224:
1223:
1215:
1214:
1208:
1205:
1204:
1196:
1195:
1189:
1183:
1182:
1179:
1178:
1170:
1169:
1163:
1160:
1159:
1151:
1150:
1144:
1138:
1137:
1132:
1127:
1123:
1122:
1112:
1111:
1108:
1107:
1096:
1095:
1093:
1092:
1087:
1082:
1077:
1075:cell migration
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
801:
799:
795:
794:
792:
791:
786:
781:
776:
771:
766:
760:
758:
754:
753:
751:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
703:kinase binding
700:
695:
690:
685:
680:
675:
670:
665:
660:
654:
652:
648:
647:
637:
636:
633:
632:
629:
628:
620:
619:
601:
595:
594:
591:
590:
582:
581:
578:
577:
575:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
531:
530:
519:
516:
515:
513:
512:
508:
504:
500:
496:
492:
488:
484:
480:
476:
472:
469:
468:
456:
455:
447:
436:
430:
429:
426:RNA expression
418:
417:
414:
413:
405:
401:
400:
392:
389:
384:
378:
377:
368:
361:
355:
351:
350:
345:
339:
338:
330:
329:
317:
316:
313:
312:
304:
300:
299:
291:
288:
283:
277:
276:
267:
260:
254:
250:
249:
242:
236:
235:
227:
226:
214:
213:
170:
166:
165:
157:
149:
148:
144:
143:
140:
139:
136:
135:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3349:
3338:
3335:
3334:
3332:
3325:
3319:
3315:
3314:
3309:
3305:
3301:
3300:
3296:
3289:
3285:
3280:
3275:
3271:
3267:
3263:
3259:
3255:
3250:
3246:
3242:
3237:
3232:
3228:
3224:
3220:
3216:
3212:
3207:
3203:
3199:
3194:
3189:
3185:
3181:
3180:J. Biol. Chem
3177:
3172:
3168:
3164:
3160:
3156:
3153:(6): 282–98.
3152:
3148:
3143:
3139:
3135:
3131:
3127:
3123:
3119:
3116:(2): 281–90.
3115:
3111:
3106:
3102:
3098:
3093:
3088:
3084:
3080:
3076:
3072:
3068:
3063:
3059:
3055:
3050:
3045:
3041:
3037:
3036:J. Biol. Chem
3033:
3028:
3024:
3020:
3016:
3012:
3008:
3004:
3000:
2996:
2991:
2987:
2983:
2978:
2973:
2969:
2965:
2961:
2957:
2953:
2949:
2945:
2940:
2936:
2932:
2927:
2922:
2919:(3): 301–11.
2918:
2914:
2910:
2905:
2901:
2897:
2892:
2887:
2883:
2879:
2875:
2870:
2866:
2862:
2857:
2852:
2848:
2844:
2840:
2836:
2832:
2828:
2824:
2819:
2815:
2811:
2807:
2803:
2798:
2793:
2789:
2785:
2781:
2776:
2772:
2768:
2763:
2758:
2754:
2750:
2746:
2742:
2738:
2733:
2729:
2725:
2721:
2717:
2713:
2709:
2704:
2700:
2696:
2692:
2688:
2684:
2680:
2676:
2672:
2667:
2663:
2659:
2654:
2649:
2645:
2641:
2640:J. Biol. Chem
2637:
2632:
2628:
2624:
2619:
2614:
2609:
2604:
2600:
2596:
2592:
2588:
2584:
2579:
2575:
2571:
2566:
2561:
2557:
2553:
2550:(2): 820–31.
2549:
2545:
2541:
2536:
2532:
2528:
2523:
2518:
2514:
2510:
2509:J. Biol. Chem
2506:
2501:
2497:
2493:
2488:
2483:
2480:(5): 2973–8.
2479:
2475:
2474:J. Biol. Chem
2471:
2466:
2465:
2460:
2449:
2446:
2441:
2437:
2432:
2427:
2423:
2419:
2416:(6): 508–14.
2415:
2411:
2407:
2400:
2397:
2392:
2388:
2383:
2378:
2374:
2370:
2366:
2362:
2358:
2354:
2350:
2343:
2340:
2335:
2331:
2327:
2323:
2319:
2315:
2311:
2307:
2300:
2298:
2294:
2289:
2285:
2281:
2277:
2272:
2267:
2263:
2259:
2258:J. Biol. Chem
2255:
2248:
2246:
2244:
2240:
2235:
2231:
2227:
2223:
2218:
2213:
2209:
2205:
2201:
2194:
2191:
2186:
2182:
2178:
2174:
2169:
2164:
2160:
2156:
2152:
2145:
2142:
2137:
2133:
2129:
2125:
2121:
2117:
2112:
2107:
2103:
2099:
2095:
2088:
2086:
2082:
2077:
2073:
2068:
2063:
2059:
2055:
2050:
2045:
2041:
2037:
2033:
2030:
2029:
2024:
2017:
2015:
2011:
2006:
2002:
1997:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1964:
1957:
1954:
1949:
1945:
1940:
1935:
1931:
1927:
1923:
1919:
1915:
1908:
1905:
1900:
1896:
1891:
1886:
1882:
1878:
1874:
1870:
1866:
1859:
1857:
1853:
1848:
1844:
1839:
1834:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1799:
1796:
1791:
1787:
1782:
1777:
1772:
1767:
1763:
1759:
1755:
1748:
1745:
1740:
1734:
1731:
1726:
1722:
1717:
1712:
1708:
1704:
1700:
1693:
1690:
1685:
1681:
1675:
1672:
1667:
1663:
1657:
1654:
1650:
1646:
1641:
1639:
1637:
1633:
1629:
1625:
1620:
1618:
1616:
1612:
1605:
1601:
1598:
1597:
1593:
1591:
1585:
1583:
1581:
1577:
1569:
1567:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1529:
1521:
1519:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1489:
1485:
1481:
1476:
1474:
1471:
1467:
1463:
1459:
1447:
1442:
1438:
1434:
1431:
1427:
1420:
1418:
1415:
1411:
1407:
1403:
1400:
1396:
1392:
1385:
1383:
1379:
1373:
1369:
1366:
1360:
1358:
1354:
1350:
1344:
1340:
1337:
1333:
1326:
1324:
1320:
1314:
1310:
1307:
1301:
1299:
1295:
1291:
1285:
1281:
1278:
1276:RefSeq (mRNA)
1274:
1267:
1266:
1261:
1257:
1254:
1248:
1247:
1242:
1238:
1235:
1233:
1229:
1222:
1221:
1216:
1212:
1209:
1203:
1202:
1197:
1193:
1190:
1188:
1184:
1177:
1176:
1171:
1167:
1164:
1158:
1157:
1152:
1148:
1145:
1143:
1139:
1136:
1133:
1131:
1128:
1124:
1121:
1117:
1113:
1106:
1102:
1097:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
802:
800:
797:
796:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
761:
759:
756:
755:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
655:
653:
650:
649:
646:
645:Gene ontology
642:
638:
626:
621:
617:
610:
605:
602:
600:
596:
588:
583:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
535:
532:
528:
523:
520:
510:
506:
502:
499:skin of thigh
498:
494:
490:
486:
482:
478:
474:
473:
470:
466:
461:
458:
457:
454:
452:
448:
446:
445:
441:
440:
437:
435:
431:
427:
423:
419:
411:
406:
402:
398:
393:
383:
379:
372:
365:
359:
352:
344:
340:
336:
331:
327:
322:
318:
310:
305:
301:
297:
292:
282:
278:
271:
264:
258:
251:
247:
241:
237:
233:
228:
224:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
167:
162:
155:
150:
145:
134:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3323:
3311:
3261:
3257:
3218:
3214:
3183:
3179:
3150:
3146:
3113:
3109:
3074:
3070:
3039:
3035:
2998:
2994:
2951:
2947:
2916:
2912:
2881:
2877:
2830:
2827:J. Cell Biol
2826:
2787:
2783:
2744:
2740:
2714:(2): 590–4.
2711:
2707:
2674:
2670:
2643:
2639:
2590:
2586:
2547:
2543:
2512:
2508:
2477:
2473:
2448:
2413:
2409:
2399:
2356:
2352:
2342:
2309:
2305:
2261:
2257:
2207:
2203:
2193:
2158:
2154:
2144:
2101:
2097:
2031:
2026:
1970:
1967:J. Cell Biol
1966:
1956:
1921:
1917:
1907:
1872:
1868:
1812:
1808:
1798:
1761:
1757:
1747:
1733:
1706:
1702:
1692:
1683:
1674:
1665:
1656:
1589:
1573:
1525:
1522:Interactions
1477:
1469:
1461:
1457:
1456:
1378:NP_001159874
1375:
1353:NP_001257437
1349:NP_001257436
1346:
1319:NM_001166402
1316:
1294:NM_001270508
1290:NM_001270507
1287:
1263:
1244:
1218:
1199:
1173:
1154:
1134:
1129:
449:
442:
307:137,883,312
294:137,867,214
169:External IDs
72:
3001:(1): 93–7.
2677:(1): 61–4.
1918:Nat Immunol
1703:J Biol Chem
1512:VE-cadherin
920:proteolysis
658:DNA binding
561:Paneth cell
557:granulocyte
491:pericardium
408:18,891,405
395:18,876,658
147:Identifiers
3221:(60): 60.
3071:Biochem. J
2544:J. Immunol
2410:Nat. Genet
2353:Biochem. J
1875:(60): 60.
1651:, May 2017
1630:, May 2017
1606:References
1488:NF-kappa B
1000:metabolism
569:left colon
507:lymph node
453:(ortholog)
190:HomoloGene
2995:FEBS Lett
2784:FEBS Lett
2671:FEBS Lett
2373:0264-6021
2326:0006-291X
2280:0021-9258
2226:0950-9232
2177:1074-7613
2120:0014-5793
2098:FEBS Lett
2058:0027-8424
1987:0021-9525
1492:apoptosis
1382:NP_033423
1357:NP_006281
1323:NM_009397
1298:NM_006290
1120:Orthologs
764:cytoplasm
475:vena cava
198:GeneCards
3331:Category
3288:12167698
3245:29796309
3202:12080044
3167:11594795
3147:Cytokine
3138:12756967
3130:11573245
3101:11463333
3058:11390377
3023:32414520
3015:11389905
2986:11009421
2935:10755617
2913:Immunity
2900:10435631
2878:Oncogene
2865:10385526
2814:19072203
2741:J. Virol
2699:29040964
2574:27986908
2440:20453842
2391:11463333
2234:10435631
2204:Oncogene
2185:10755617
2155:Immunity
2136:19072203
2005:10385526
1948:24487321
1899:29796309
1847:11009421
1790:29881386
1764:: 1136.
1647:–
1626:–
1594:See also
1528:interact
1500:cnidaria
1430:Wikidata
1099:Sources:
774:lysosome
483:appendix
3318:PDBe-KB
3308:UniProt
3236:5955943
3092:1221992
2977:3582399
2956:Bibcode
2948:Science
2856:2133159
2806:9928991
2771:9882303
2728:9299557
2691:8797804
2662:8702721
2627:8692885
2595:Bibcode
2565:5220121
2531:8663499
2496:2406243
2431:4243840
2382:1221992
2334:9299557
2288:8702721
2128:9928991
2076:8692885
2036:Bibcode
1996:2133159
1939:4005385
1890:5955943
1838:3582399
1817:Bibcode
1809:Science
1781:5978004
1725:2118515
1649:Ensembl
1628:Ensembl
1548:TAX1BP1
1496:homolog
1470:TNFAIP3
1466:protein
1232:UniProt
1187:Ensembl
1126:Species
1105:QuickGO
784:nucleus
769:cytosol
565:jejunum
428:pattern
202:TNFAIP3
186:1196377
161:TNFAIP3
154:Aliases
22:TNFAIP3
3313:P21580
3286:
3279:133997
3276:
3243:
3233:
3200:
3165:
3136:
3128:
3099:
3089:
3056:
3021:
3013:
2984:
2974:
2933:
2898:
2863:
2853:
2812:
2804:
2769:
2762:103922
2759:
2726:
2697:
2689:
2660:
2625:
2615:
2572:
2562:
2529:
2494:
2438:
2428:
2389:
2379:
2371:
2332:
2324:
2286:
2278:
2232:
2224:
2183:
2175:
2134:
2126:
2118:
2074:
2064:
2056:
2003:
1993:
1985:
1946:
1936:
1897:
1887:
1845:
1835:
1788:
1778:
1723:
1508:KCHIP3
1482:and a
1416:search
1414:PubMed
1265:Q60769
1246:P21580
1142:Entrez
599:BioGPS
549:thymus
503:thymus
286:6q23.3
178:191163
3134:S2CID
3019:S2CID
2810:S2CID
2695:S2CID
2618:39093
2132:S2CID
2067:39093
1564:YWHAH
1560:TRAF6
1556:YWHAZ
1552:YWHAB
1544:IKBKG
1540:TRAF2
1536:TRAF1
1532:TNIP1
1530:with
1464:is a
1175:21929
1135:Mouse
1130:Human
1101:Amigo
451:Mouse
444:Human
391:Start
326:Mouse
290:Start
223:Human
3306:for
3284:PMID
3241:PMID
3198:PMID
3163:PMID
3126:PMID
3097:PMID
3054:PMID
3011:PMID
2982:PMID
2931:PMID
2896:PMID
2861:PMID
2802:PMID
2767:PMID
2724:PMID
2687:PMID
2658:PMID
2623:PMID
2570:PMID
2527:PMID
2492:PMID
2436:PMID
2387:PMID
2369:ISSN
2330:PMID
2322:ISSN
2284:PMID
2276:ISSN
2230:PMID
2222:ISSN
2181:PMID
2173:ISSN
2124:PMID
2116:ISSN
2072:PMID
2054:ISSN
2001:PMID
1983:ISSN
1944:PMID
1895:PMID
1843:PMID
1786:PMID
1721:PMID
1580:SNPs
1562:and
1473:gene
1156:7128
434:Bgee
382:Band
343:Chr.
281:Band
240:Chr.
194:4582
174:OMIM
131:4ZS5
127:4ZRH
123:3ZJG
119:3ZJF
115:3ZJE
111:3ZJD
107:3VUY
103:3VUX
99:3VUW
95:3OJ4
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75:2EQF
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3304:PDB
3274:PMC
3266:doi
3231:PMC
3223:doi
3188:doi
3184:277
3155:doi
3118:doi
3087:PMC
3079:doi
3075:357
3044:doi
3040:276
3003:doi
2999:498
2972:PMC
2964:doi
2952:289
2921:doi
2886:doi
2851:PMC
2843:hdl
2835:doi
2831:145
2792:doi
2788:442
2757:PMC
2749:doi
2716:doi
2712:238
2679:doi
2675:384
2648:doi
2644:271
2613:PMC
2603:doi
2560:PMC
2552:doi
2548:198
2517:doi
2513:271
2482:doi
2478:265
2426:PMC
2418:doi
2377:PMC
2361:doi
2357:357
2314:doi
2310:238
2266:doi
2262:271
2212:doi
2163:doi
2106:doi
2102:442
2062:PMC
2044:doi
1991:PMC
1975:doi
1971:145
1934:PMC
1926:doi
1885:PMC
1877:doi
1833:PMC
1825:doi
1813:289
1776:PMC
1766:doi
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