195:
220:
428:
40:
226:
1112:(OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40-Ig can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
66:
1032:
production. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response due to its ability to enhance survival. OX40 also plays a crucial role in both
1221:
1016:
cells for the first three days, however after this time proliferation begins to slow and cells die at a greater rate, due to an inability to maintain a high level of PKB activity and expression of
4923:
4282:
2516:
4707:
1070:
is down-regulated following OX40 engagement in vivo and the OX40-specific TRAF3 DN defect was partially overcome by CTLA-4 blockade in vivo. TRAF3 may be linked to OX40-mediated
1655:
1347:"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB"
233:
1000:, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without
1460:
Song J, Salek-Ardakani S, Rogers PR, Cheng M, Van Parijs L, Croft M (February 2004). "The costimulation-regulated duration of PKB activation controls T cell longevity".
4939:
5401:
1225:
4867:
4405:
2506:
4989:
5421:
3692:
1306:"Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation"
1074:
expansion and survival, and point to the down-regulation of CTLA-4 as a possible control element to enhance early T cell expansion through OX40 signaling.
5049:
4700:
2486:
706:
687:
156:
4082:
3348:
1672:
1648:
1062:
seems to have a more negative or modulatory role, as knockouts have higher levels of cytokines and are more susceptible to Th2-mediated inflammation.
5392:
5381:
5357:
4847:
4653:
4371:
4367:
4350:
3079:
4736:
4484:
4459:
4323:
3067:
2845:
4883:
4693:
4488:
4463:
4314:
3131:
3126:
3072:
2852:
1633:
1203:
1185:
5788:
5778:
5015:
4641:
4340:
4275:
2585:
2511:
1641:
1115:
An anti-OX40 antibody GSK3174998 has started clinical trials as a cancer treatment. Research in mice has included the combination of an
4335:
3614:
3609:
3604:
3599:
2526:
1398:
4747:
5701:
3579:
904:
4214:
3919:
3911:
3685:
2815:
4562:
3860:
3383:
2877:
2563:
1172:
5412:
5114:
4557:
4505:
3896:
3022:
2558:
1404:
219:
194:
127:, ACT35, CD134, IMD16, OX40, TXGP1L, tumor necrosis factor receptor superfamily member 4, TNF receptor superfamily member 4
63:
3809:
3771:
3766:
3519:
2991:
2986:
2931:
2665:
2114:
1168:
5716:
3814:
3213:
2936:
136:
232:
4526:
4522:
3678:
2531:
1136:
4227:
225:
5706:
5348:
4542:
4158:
3714:
3243:
1668:
5307:
4777:
4518:
4442:
4141:
3927:
2109:
4672:
4636:
4167:
3293:
2188:
144:
5060:
4756:
4591:
4569:
4493:
4480:
4467:
4455:
4423:
4410:
4400:
4376:
4363:
4319:
4310:
4237:
4210:
4201:
3796:
3257:
732:
4772:
5445:
4628:
4552:
4305:
4271:
4262:
4232:
4223:
4206:
3804:
3724:
2600:
2595:
2590:
2580:
1887:
1815:
5257:
5252:
5203:
4330:
1944:
1862:
1532:
Croft M (August 2003). "Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?".
993:
4842:
4857:
5372:
5208:
4913:
4807:
4450:
4358:
4300:
4257:
4184:
3181:
2894:
208:
123:
5615:
5323:
5213:
5105:
4822:
4817:
4812:
4802:
4667:
4662:
4500:
3208:
3027:
1410:
1120:
1028:. OX40L binds to OX40 receptors on T-cells, preventing them from dying and subsequently increasing
5076:
4934:
4903:
1571:"OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells"
5237:
5232:
5198:
5193:
5139:
4954:
4727:
4719:
4657:
4428:
4176:
3709:
2615:
2349:
1557:
1485:
168:
5726:
5030:
5020:
5010:
4944:
4893:
887:
866:
840:
819:
427:
5655:
5645:
5635:
5572:
5297:
5000:
5665:
5650:
5567:
5532:
5277:
4782:
4716:
3701:
1621:
1592:
1549:
1520:
1499:"Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion"
1477:
1448:
1376:
1327:
1286:
1268:
1119:
OX40 antibody (clone OX86) injected directly into a tumor in combination with an unmethylated
989:
116:
56:
5592:
4767:
1617:
164:
5783:
5318:
5247:
5242:
5130:
4787:
4616:
4419:
4292:
4133:
4125:
4026:
4018:
4010:
4002:
3388:
3121:
3042:
2605:
1798:
1724:
1613:
1582:
1541:
1510:
1469:
1438:
1366:
1358:
1317:
1276:
1260:
312:
243:
5226:
5696:
5673:
5218:
5135:
4898:
4042:
3448:
1984:
1979:
1902:
1222:"GSK and Merck to study immunotherapy combination as potential cancer treatment. Nov 2015"
1093:
287:
39:
5557:
5547:
5474:
5091:
5081:
5005:
4837:
3943:
3233:
2655:
2166:
1969:
1281:
1248:
1109:
1105:
1086:
1587:
1570:
1371:
1346:
1054:, 3 and 5 as well as PI3K by an unknown mechanism. TRAF2 is required for survival via
621:
616:
611:
606:
601:
596:
591:
586:
581:
576:
571:
566:
561:
556:
551:
546:
541:
536:
520:
515:
510:
505:
500:
495:
479:
474:
469:
5772:
5125:
4908:
4827:
4395:
4189:
3203:
2660:
1751:
1071:
456:
1561:
1489:
1247:
Sagiv-Barfi I, Czerwinski DK, Levy S, Alam IS, Mayer AT, Gambhir SS, Levy R (2018).
5731:
5711:
5630:
5620:
5562:
5509:
5439:
5338:
5282:
4969:
4959:
4949:
4852:
4832:
4797:
4792:
4583:
3951:
3559:
2867:
2857:
2388:
2354:
305:
185:
148:
1604:
Watts TH (2005). "TNF/TNFR family members in costimulation of T cell responses".
1515:
1498:
1264:
980:-superfamily of receptors which is not constitutively expressed on resting naïve
172:
5741:
5736:
5640:
5625:
5597:
5587:
5582:
5537:
5504:
5499:
5494:
5489:
5484:
5469:
5464:
5287:
5272:
5267:
5086:
5071:
4888:
3776:
3751:
3569:
3218:
2996:
2971:
2670:
2292:
2218:
1692:
1443:
1426:
1208:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1190:
National Center for
Biotechnology Information, U.S. National Library of Medicine
4685:
1427:"TNF receptor-associated factor 5 limits the induction of Th2 immune responses"
5577:
5479:
5333:
4878:
3499:
3223:
2904:
2645:
2521:
2154:
2149:
2144:
1999:
1783:
1083:
202:
152:
1272:
5751:
5746:
5527:
4974:
4066:
4058:
4050:
3338:
3333:
3328:
3318:
3313:
3308:
3303:
1322:
1305:
1116:
651:
405:
326:
271:
258:
160:
1625:
1596:
1553:
1524:
1481:
1452:
1290:
1380:
1331:
949:
944:
4979:
4106:
4098:
4090:
4074:
3644:
3544:
3358:
3343:
2546:
2541:
2449:
2139:
1362:
1055:
1034:
1029:
1025:
933:
794:
775:
4475:
4471:
4218:
3594:
3589:
3584:
3484:
3298:
3288:
3115:
3094:
3089:
3057:
2862:
2782:
2777:
2772:
2767:
2762:
2680:
2373:
2213:
2208:
2203:
2198:
2193:
1664:
1304:
Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T (March 1998).
1043:
981:
761:
718:
17:
93:
89:
85:
5552:
5542:
5187:
5183:
5179:
5175:
5171:
5167:
4611:
4606:
4601:
4596:
4573:
4513:
4509:
4249:
3882:
3670:
3534:
3494:
3479:
3463:
3458:
3438:
3433:
3368:
3176:
3146:
3110:
3101:
2914:
2882:
2746:
2741:
2711:
2690:
2650:
2610:
2476:
2454:
2413:
2337:
2332:
2327:
2322:
2317:
2312:
2181:
2176:
2171:
2119:
2104:
1974:
1964:
1927:
1922:
1840:
1835:
1569:
Rogers PR, Song J, Gramaglia I, Killeen N, Croft M (September 2001).
1067:
1021:
917:
673:
1545:
1473:
1013:
992:
molecule, expressed after 24 to 72 hours following activation; its
5222:
5163:
5159:
5155:
5151:
5147:
5143:
5040:
4646:
4266:
4197:
4193:
3983:
3877:
3841:
3836:
3831:
3826:
3821:
3786:
3746:
3736:
3659:
3634:
3554:
3549:
3539:
3529:
3514:
3509:
3504:
3489:
3443:
3428:
3393:
3378:
3373:
3363:
3283:
3278:
3273:
3252:
3248:
3238:
3151:
3052:
3047:
3006:
2956:
2951:
2946:
2941:
2926:
2919:
2899:
2887:
2830:
2825:
2820:
2810:
2805:
2798:
2736:
2726:
2721:
2716:
2706:
2685:
2675:
2640:
2635:
2630:
2620:
2575:
2570:
2536:
2501:
2496:
2491:
2481:
2469:
2464:
2444:
2439:
2434:
2429:
2383:
2275:
2270:
2089:
2073:
2066:
2061:
2056:
2051:
2046:
2041:
2016:
1994:
1989:
1882:
1808:
1803:
1793:
1144:
1140:
1063:
1059:
1051:
1017:
997:
1425:
So T, Salek-Ardakani S, Nakano H, Ware CF, Croft M (April 2004).
636:
632:
5607:
5519:
5456:
4034:
3975:
3967:
3959:
3870:
3781:
3761:
3756:
3741:
3732:
3654:
3649:
3639:
3629:
3624:
3619:
3574:
3564:
3524:
3453:
3423:
3418:
3413:
3408:
3403:
3398:
3353:
3323:
3228:
3196:
3191:
3171:
3161:
3156:
3141:
3136:
3037:
3032:
3001:
2981:
2976:
2966:
2961:
2840:
2793:
2753:
2408:
2403:
2398:
2393:
2378:
2369:
2364:
2359:
2344:
2302:
2297:
2287:
2282:
2265:
2260:
2255:
2250:
2245:
2240:
2235:
2230:
2225:
2161:
2134:
2129:
2124:
2099:
2094:
2031:
2026:
2021:
2011:
2006:
1959:
1954:
1949:
1939:
1934:
1917:
1912:
1907:
1897:
1892:
1877:
1872:
1867:
1857:
1852:
1847:
1830:
1825:
1820:
1771:
1739:
1734:
1729:
1712:
1707:
1702:
1697:
1127:
ligand activates expression of OX40 so that it can be affected.
1124:
1090:
1001:
985:
977:
547:
negative regulation of DNA-binding transcription factor activity
140:
4689:
3674:
1637:
1066:
may play a critical role in OX40-mediated signal transduction.
617:
negative regulation of activation-induced cell death of T cells
436:
3166:
1778:
1766:
1761:
1756:
1746:
1719:
1687:
1249:"Eradication of spontaneous malignancy by local immunotherapy"
1038:
1004:, expression of OX40 is delayed and of fourfold lower levels.
622:
negative regulation of extrinsic apoptotic signaling pathway
1089:
associated with certain viral infections, including the
295:
4848:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
1012:
OX40 has no effect on the proliferative abilities of
417:
962:
Tumor necrosis factor receptor superfamily, member 4
5686:
5664:
5606:
5518:
5455:
5438:
5431:
5411:
5391:
5371:
5347:
5306:
5113:
5104:
5059:
5039:
4988:
4922:
4866:
4755:
4746:
4726:
4627:
4582:
4541:
4441:
4387:
4349:
4291:
4248:
4175:
4166:
4157:
4118:
3995:
3904:
3895:
3850:
3795:
3723:
3708:
3472:
3266:
3015:
2699:
2422:
2082:
1680:
1497:Song J, So T, Cheng M, Tang X, Croft M (May 2005).
880:
859:
833:
812:
597:
negative regulation of transcription, DNA-templated
1164:
1162:
1160:
475:tumor necrosis factor-activated receptor activity
242:
4940:Granulocyte macrophage colony-stimulating factor
542:tumor necrosis factor-mediated signaling pathway
4701:
3686:
1649:
8:
1169:GRCh38: Ensembl release 89: ENSG00000186827
572:positive regulation of B cell proliferation
567:regulation of cell population proliferation
5707:Leukemia/leukocyte inhibitory factor (LIF)
5452:
5435:
5110:
4752:
4708:
4694:
4686:
4172:
4163:
3901:
3720:
3693:
3679:
3671:
1656:
1642:
1634:
647:
452:
283:
180:
74:
5702:FMS-like tyrosine kinase 3 ligand (FLT3L)
5131:Interferon alpha (interferon alfa, IFN-α)
1673:list of human clusters of differentiation
1586:
1514:
1442:
1370:
1321:
1280:
5724:Additional cytokine receptor modulators:
1618:10.1146/annurev.immunol.23.021704.115839
1156:
5548:Cucurbitacin I (elatericin B, JSI-124)
29:
4884:Granulocyte colony-stimulating factor
1345:Arch RH, Thompson CB (January 1998).
988:. OX40 is a secondary co-stimulatory
612:regulation of protein kinase activity
511:integral component of plasma membrane
247:
206:
201:
7:
5243:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
5016:Macrophage colony-stimulating factor
5717:Thymic stromal lymphopoietin (TSLP)
1310:The Journal of Biological Chemistry
1058:and memory cell generation whereas
877:
856:
830:
809:
785:
766:
742:
723:
697:
678:
552:multicellular organism development
422:
383:
321:
300:
25:
1104:An artificially created biologic
1082:OX40 has been implicated in the
521:external side of plasma membrane
426:
231:
224:
218:
193:
38:
5248:Interferon omega (IFN-ω, IFNW1)
537:regulation of apoptotic process
1351:Molecular and Cellular Biology
1253:Science Translational Medicine
562:response to lipopolysaccharide
496:integral component of membrane
437:More reference expression data
406:More reference expression data
1:
1588:10.1016/S1074-7613(01)00191-1
216:
27:Protein-coding gene in humans
1516:10.1016/j.immuni.2005.03.012
1265:10.1126/scitranslmed.aan4488
5789:Clusters of differentiation
5779:Genes on human chromosome 1
5092:Thrombopoietin (THPO, MGDF)
4858:Pegol sihematide (EPO-018B)
4778:Carbamylated erythropoietin
1669:clusters of differentiation
1606:Annual Review of Immunology
1444:10.4049/jimmunol.172.7.4292
582:apoptotic signaling pathway
5805:
1534:Nature Reviews. Immunology
1409:gene details page in the
587:viral entry into host cell
361:mucosa of transverse colon
5641:Tofacitinib (tasocitinib)
5598:Tofacitinib (tasocitinib)
5505:Tofacitinib (tasocitinib)
1204:"Mouse PubMed Reference:"
1186:"Human PubMed Reference:"
948:
943:
939:
932:
916:
899:
884:
863:
852:
837:
816:
805:
792:
788:
773:
769:
760:
749:
745:
730:
726:
717:
704:
700:
685:
681:
672:
657:
650:
646:
630:
607:cellular defense response
455:
451:
434:
425:
416:
403:
390:
386:
333:
324:
294:
286:
282:
265:
252:
215:
192:
183:
179:
134:
131:
121:
114:
109:
82:
77:
60:
55:
50:
46:
37:
32:
5319:Interferon gamma (IFN-γ)
1135:CD134 has been shown to
1100:As a drug or drug target
5219:Interferon beta (IFN-β)
1323:10.1074/jbc.273.10.5808
470:virus receptor activity
365:upper lobe of left lung
5697:Cardiotrophin 1 (CT-1)
4629:Enzyme-linked receptor
5694:Additional cytokines:
5621:Decernotinib (VX-509)
5258:Peginterferon alfa-2b
5253:Peginterferon alfa-2a
4773:Asialo erythropoietin
4451:Interleukin receptors
4359:Interleukin receptors
4301:Interleukin receptors
4258:Interleukin receptors
4185:Interleukin receptors
1431:Journal of Immunology
1078:Clinical significance
976:, is a member of the
905:Chr 1: 1.21 – 1.21 Mb
592:inflammatory response
5209:Interferon alfacon-1
4838:Erythropoietin (EPO)
4501:Interferon receptors
1403:genome location and
1363:10.1128/MCB.18.1.558
557:T cell proliferation
209:Chromosome 1 (human)
78:List of PDB id codes
51:Available structures
5356:See IL-28R (IFNLR)
5324:Interferon gamma 1b
5214:Interferon alpha-n3
1411:UCSC Genome Browser
1121:CpG oligonucleotide
1041:mediated reactions
173:TNFRSF4 - orthologs
5712:Oncostatin M (OSM)
5238:Interferon beta 1b
5233:Interferon beta 1a
5204:Interferon alfa n1
5199:Interferon alfa 2b
5194:Interferon alfa 2a
5028:Kinase inhibitors:
3710:Chemokine receptor
3702:Cytokine receptors
1228:on 4 February 2017
530:Biological process
489:Cellular component
463:Molecular function
5764:
5763:
5760:
5759:
5682:
5681:
5449:
5367:
5366:
5100:
5099:
4843:Erythropoietin-Fc
4717:Cytokine receptor
4683:
4682:
4537:
4536:
4437:
4436:
4153:
4152:
3891:
3890:
3668:
3667:
1462:Nature Immunology
1259:(426): eaan4488.
990:immune checkpoint
968:), also known as
959:
958:
955:
954:
928:
927:
895:
894:
874:
873:
848:
847:
827:
826:
801:
800:
782:
781:
756:
755:
739:
738:
713:
712:
694:
693:
642:
641:
447:
446:
443:
442:
412:
411:
399:
398:
380:
379:
278:
277:
105:
104:
101:
100:
61:Ortholog search:
16:(Redirected from
5796:
5453:
5443:
5436:
5295:Decoy receptors:
5111:
4788:Darbepoetin alfa
4753:
4710:
4703:
4696:
4687:
4420:hormone receptor
4173:
4164:
3902:
3721:
3695:
3688:
3681:
3672:
1658:
1651:
1644:
1635:
1629:
1600:
1590:
1565:
1528:
1518:
1493:
1456:
1446:
1385:
1384:
1374:
1342:
1336:
1335:
1325:
1301:
1295:
1294:
1284:
1244:
1238:
1237:
1235:
1233:
1224:. Archived from
1218:
1212:
1211:
1200:
1194:
1193:
1182:
1176:
1166:
941:
940:
912:
907:
890:
878:
869:
857:
853:RefSeq (protein)
843:
831:
822:
810:
786:
767:
743:
724:
698:
679:
648:
453:
439:
430:
423:
408:
384:
357:cartilage tissue
329:
327:Top expressed in
322:
301:
284:
274:
261:
250:
235:
228:
222:
211:
197:
181:
175:
126:
119:
96:
75:
69:
48:
47:
42:
30:
21:
5804:
5803:
5799:
5798:
5797:
5795:
5794:
5793:
5769:
5768:
5765:
5756:
5678:
5674:Deucravacitinib
5660:
5602:
5514:
5442:
5427:
5407:
5387:
5363:
5343:
5302:
5136:Interferon alfa
5096:
5055:
5035:
4984:
4918:
4914:Pegnartograstim
4899:Lipegfilgrastim
4862:
4808:Epoetin epsilon
4742:
4722:
4714:
4684:
4679:
4623:
4578:
4533:
4433:
4383:
4345:
4287:
4244:
4149:
4114:
4043:Osteoprotegerin
3991:
3887:
3846:
3791:
3712:
3704:
3699:
3669:
3664:
3468:
3262:
3011:
2695:
2418:
2078:
1676:
1662:
1632:
1603:
1568:
1546:10.1038/nri1148
1531:
1496:
1459:
1424:
1420:
1418:Further reading
1394:
1389:
1388:
1344:
1343:
1339:
1316:(10): 5808–14.
1303:
1302:
1298:
1246:
1245:
1241:
1231:
1229:
1220:
1219:
1215:
1202:
1201:
1197:
1184:
1183:
1179:
1167:
1158:
1153:
1133:
1102:
1080:
1010:
950:View/Edit Mouse
945:View/Edit Human
910:
903:
900:Location (UCSC)
886:
865:
839:
818:
733:ENSG00000186827
626:
577:immune response
525:
506:plasma membrane
484:
480:protein binding
435:
404:
395:
376:
371:
367:
363:
359:
355:
351:
347:
343:
339:
325:
269:
256:
248:
238:
237:
236:
229:
207:
184:Gene location (
135:
122:
115:
84:
62:
28:
23:
22:
15:
12:
11:
5:
5802:
5800:
5792:
5791:
5786:
5781:
5771:
5770:
5762:
5761:
5758:
5757:
5755:
5754:
5749:
5744:
5739:
5734:
5729:
5720:
5719:
5714:
5709:
5704:
5699:
5690:
5688:
5684:
5683:
5680:
5679:
5677:
5676:
5670:
5668:
5662:
5661:
5659:
5658:
5653:
5648:
5643:
5638:
5633:
5628:
5623:
5618:
5616:Cercosporamide
5612:
5610:
5604:
5603:
5601:
5600:
5595:
5590:
5585:
5580:
5575:
5570:
5565:
5560:
5558:Deuruxolitinib
5555:
5550:
5545:
5540:
5535:
5530:
5524:
5522:
5516:
5515:
5513:
5512:
5507:
5502:
5497:
5492:
5487:
5482:
5477:
5475:Deuruxolitinib
5472:
5467:
5461:
5459:
5450:
5433:
5429:
5428:
5426:
5425:
5417:
5415:
5409:
5408:
5406:
5405:
5397:
5395:
5389:
5388:
5386:
5385:
5377:
5375:
5369:
5368:
5365:
5364:
5362:
5361:
5353:
5351:
5349:IFNLR (λ, III)
5345:
5344:
5342:
5341:
5336:
5327:
5326:
5321:
5312:
5310:
5304:
5303:
5301:
5300:
5291:
5290:
5285:
5280:
5275:
5270:
5261:
5260:
5255:
5250:
5245:
5240:
5235:
5230:
5216:
5211:
5206:
5201:
5196:
5191:
5133:
5128:
5119:
5117:
5115:IFNAR (α/β, I)
5108:
5102:
5101:
5098:
5097:
5095:
5094:
5089:
5084:
5082:Promegapoietin
5079:
5074:
5065:
5063:
5061:Thrombopoietin
5057:
5056:
5054:
5053:
5045:
5043:
5037:
5036:
5034:
5033:
5024:
5023:
5018:
5013:
5008:
5006:Interleukin-34
5003:
4994:
4992:
4986:
4985:
4983:
4982:
4977:
4972:
4963:
4962:
4957:
4952:
4947:
4942:
4937:
4928:
4926:
4920:
4919:
4917:
4916:
4911:
4906:
4901:
4896:
4891:
4886:
4881:
4872:
4870:
4864:
4863:
4861:
4860:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4820:
4815:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4775:
4770:
4761:
4759:
4757:Erythropoietin
4750:
4744:
4743:
4741:
4740:
4732:
4730:
4724:
4723:
4715:
4713:
4712:
4705:
4698:
4690:
4681:
4680:
4678:
4677:
4676:
4675:
4670:
4665:
4651:
4650:
4649:
4644:
4633:
4631:
4625:
4624:
4622:
4621:
4620:
4619:
4614:
4609:
4604:
4599:
4588:
4586:
4580:
4579:
4577:
4576:
4567:
4566:
4565:
4560:
4550:
4547:
4545:
4543:Ig superfamily
4539:
4538:
4535:
4534:
4532:
4531:
4530:
4529:
4516:
4498:
4497:
4496:
4491:
4478:
4447:
4445:
4439:
4438:
4435:
4434:
4432:
4431:
4426:
4416:
4415:
4414:
4413:
4411:Thrombopoietin
4408:
4403:
4391:
4389:
4385:
4384:
4382:
4381:
4380:
4379:
4374:
4355:
4353:
4347:
4346:
4344:
4343:
4338:
4333:
4328:
4327:
4326:
4317:
4308:
4297:
4295:
4289:
4288:
4286:
4285:
4280:
4279:
4278:
4269:
4254:
4252:
4246:
4245:
4243:
4242:
4241:
4240:
4235:
4230:
4221:
4204:
4181:
4179:
4170:
4161:
4155:
4154:
4151:
4150:
4148:
4147:
4139:
4131:
4122:
4120:
4116:
4115:
4113:
4112:
4104:
4096:
4088:
4080:
4072:
4064:
4056:
4048:
4040:
4032:
4024:
4016:
4008:
3999:
3997:
3993:
3992:
3990:
3989:
3981:
3973:
3965:
3957:
3949:
3941:
3933:
3925:
3917:
3908:
3906:
3899:
3893:
3892:
3889:
3888:
3886:
3885:
3880:
3875:
3874:
3873:
3865:
3864:
3863:
3854:
3852:
3848:
3847:
3845:
3844:
3839:
3834:
3829:
3824:
3819:
3818:
3817:
3812:
3801:
3799:
3793:
3792:
3790:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3729:
3727:
3718:
3706:
3705:
3700:
3698:
3697:
3690:
3683:
3675:
3666:
3665:
3663:
3662:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3577:
3572:
3567:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3476:
3474:
3470:
3469:
3467:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3391:
3386:
3381:
3376:
3371:
3366:
3361:
3356:
3351:
3346:
3341:
3336:
3331:
3326:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3270:
3268:
3264:
3263:
3261:
3260:
3255:
3246:
3241:
3236:
3231:
3226:
3221:
3216:
3211:
3206:
3201:
3200:
3199:
3194:
3184:
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3139:
3134:
3129:
3124:
3119:
3113:
3104:
3099:
3098:
3097:
3092:
3082:
3077:
3076:
3075:
3070:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3019:
3017:
3013:
3012:
3010:
3009:
3004:
2999:
2994:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2923:
2922:
2917:
2907:
2902:
2897:
2892:
2891:
2890:
2885:
2880:
2870:
2865:
2860:
2855:
2850:
2849:
2848:
2843:
2833:
2828:
2823:
2818:
2813:
2808:
2803:
2802:
2801:
2796:
2786:
2780:
2775:
2770:
2765:
2756:
2751:
2750:
2749:
2744:
2739:
2729:
2724:
2719:
2714:
2709:
2703:
2701:
2697:
2696:
2694:
2693:
2688:
2683:
2678:
2673:
2668:
2663:
2658:
2653:
2648:
2643:
2638:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2578:
2573:
2568:
2567:
2566:
2561:
2551:
2550:
2549:
2544:
2534:
2529:
2524:
2519:
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2479:
2474:
2473:
2472:
2467:
2457:
2452:
2447:
2442:
2437:
2432:
2426:
2424:
2420:
2419:
2417:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2381:
2376:
2367:
2362:
2357:
2352:
2347:
2342:
2341:
2340:
2335:
2330:
2325:
2320:
2315:
2305:
2300:
2295:
2290:
2285:
2280:
2279:
2278:
2273:
2263:
2258:
2253:
2248:
2243:
2238:
2233:
2228:
2223:
2222:
2221:
2216:
2211:
2206:
2201:
2196:
2186:
2185:
2184:
2179:
2174:
2164:
2159:
2158:
2157:
2152:
2147:
2137:
2132:
2127:
2122:
2117:
2112:
2107:
2102:
2097:
2092:
2086:
2084:
2080:
2079:
2077:
2076:
2071:
2070:
2069:
2064:
2059:
2054:
2049:
2044:
2034:
2029:
2024:
2019:
2014:
2009:
2004:
2003:
2002:
1997:
1992:
1987:
1977:
1972:
1967:
1962:
1957:
1952:
1947:
1942:
1937:
1932:
1931:
1930:
1925:
1915:
1910:
1905:
1900:
1895:
1890:
1885:
1880:
1875:
1870:
1865:
1860:
1855:
1850:
1845:
1844:
1843:
1838:
1828:
1823:
1818:
1813:
1812:
1811:
1806:
1801:
1796:
1786:
1781:
1776:
1775:
1774:
1764:
1759:
1754:
1749:
1744:
1743:
1742:
1737:
1732:
1722:
1717:
1716:
1715:
1710:
1705:
1700:
1695:
1684:
1682:
1678:
1677:
1663:
1661:
1660:
1653:
1646:
1638:
1631:
1630:
1601:
1566:
1529:
1494:
1474:10.1038/ni1030
1457:
1421:
1419:
1416:
1415:
1414:
1393:
1392:External links
1390:
1387:
1386:
1337:
1296:
1239:
1213:
1195:
1177:
1155:
1154:
1152:
1149:
1132:
1129:
1110:immunoglobulin
1106:fusion protein
1101:
1098:
1087:cytokine storm
1079:
1076:
1009:
1006:
957:
956:
953:
952:
947:
937:
936:
930:
929:
926:
925:
923:
921:
914:
913:
908:
901:
897:
896:
893:
892:
882:
881:
875:
872:
871:
861:
860:
854:
850:
849:
846:
845:
835:
834:
828:
825:
824:
814:
813:
807:
803:
802:
799:
798:
790:
789:
783:
780:
779:
771:
770:
764:
758:
757:
754:
753:
747:
746:
740:
737:
736:
728:
727:
721:
715:
714:
711:
710:
702:
701:
695:
692:
691:
683:
682:
676:
670:
669:
664:
659:
655:
654:
644:
643:
640:
639:
628:
627:
625:
624:
619:
614:
609:
604:
599:
594:
589:
584:
579:
574:
569:
564:
559:
554:
549:
544:
539:
533:
531:
527:
526:
524:
523:
518:
513:
508:
503:
498:
492:
490:
486:
485:
483:
482:
477:
472:
466:
464:
460:
459:
449:
448:
445:
444:
441:
440:
432:
431:
420:
414:
413:
410:
409:
401:
400:
397:
396:
394:
391:
388:
387:
381:
378:
377:
375:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
331:
330:
318:
317:
309:
298:
292:
291:
288:RNA expression
280:
279:
276:
275:
267:
263:
262:
254:
251:
246:
240:
239:
230:
223:
217:
213:
212:
205:
199:
198:
190:
189:
177:
176:
133:
129:
128:
120:
112:
111:
107:
106:
103:
102:
99:
98:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5801:
5790:
5787:
5785:
5782:
5780:
5777:
5776:
5774:
5767:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5722:
5721:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5700:
5698:
5695:
5692:
5691:
5689:
5685:
5675:
5672:
5671:
5669:
5667:
5663:
5657:
5654:
5652:
5649:
5647:
5644:
5642:
5639:
5637:
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5617:
5614:
5613:
5611:
5609:
5605:
5599:
5596:
5594:
5591:
5589:
5586:
5584:
5581:
5579:
5576:
5574:
5571:
5569:
5566:
5564:
5561:
5559:
5556:
5554:
5551:
5549:
5546:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5525:
5523:
5521:
5517:
5511:
5508:
5506:
5503:
5501:
5498:
5496:
5493:
5491:
5488:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5462:
5460:
5458:
5454:
5451:
5447:
5441:
5437:
5434:
5430:
5423:
5419:
5418:
5416:
5414:
5410:
5403:
5399:
5398:
5396:
5394:
5390:
5383:
5379:
5378:
5376:
5374:
5370:
5359:
5355:
5354:
5352:
5350:
5346:
5340:
5337:
5335:
5332:
5329:
5328:
5325:
5322:
5320:
5317:
5314:
5313:
5311:
5309:
5308:IFNGR (γ, II)
5305:
5299:
5296:
5293:
5292:
5289:
5286:
5284:
5281:
5279:
5276:
5274:
5271:
5269:
5266:
5263:
5262:
5259:
5256:
5254:
5251:
5249:
5246:
5244:
5241:
5239:
5236:
5234:
5231:
5228:
5224:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5197:
5195:
5192:
5189:
5185:
5181:
5177:
5173:
5169:
5165:
5161:
5157:
5153:
5149:
5145:
5141:
5137:
5134:
5132:
5129:
5127:
5126:Albinterferon
5124:
5121:
5120:
5118:
5116:
5112:
5109:
5107:
5103:
5093:
5090:
5088:
5085:
5083:
5080:
5078:
5075:
5073:
5070:
5067:
5066:
5064:
5062:
5058:
5051:
5047:
5046:
5044:
5042:
5038:
5032:
5029:
5026:
5025:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4996:
4995:
4993:
4991:
4987:
4981:
4978:
4976:
4973:
4971:
4968:
4965:
4964:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4930:
4929:
4927:
4925:
4924:GM-CSF (CSF2)
4921:
4915:
4912:
4910:
4909:Pegfilgrastim
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4874:
4873:
4871:
4869:
4865:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4828:Epoetin theta
4826:
4824:
4823:Epoetin omega
4821:
4819:
4818:Epoetin kappa
4816:
4814:
4813:Epoetin gamma
4811:
4809:
4806:
4804:
4803:Epoetin delta
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4774:
4771:
4769:
4766:
4763:
4762:
4760:
4758:
4754:
4751:
4749:
4745:
4738:
4734:
4733:
4731:
4729:
4725:
4721:
4718:
4711:
4706:
4704:
4699:
4697:
4692:
4691:
4688:
4674:
4671:
4669:
4666:
4664:
4661:
4660:
4659:
4655:
4652:
4648:
4645:
4643:
4640:
4639:
4638:
4635:
4634:
4632:
4630:
4626:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4594:
4593:
4590:
4589:
4587:
4585:
4581:
4575:
4571:
4568:
4564:
4561:
4559:
4556:
4555:
4554:
4551:
4549:
4548:
4546:
4544:
4540:
4528:
4524:
4520:
4517:
4515:
4511:
4507:
4504:
4503:
4502:
4499:
4495:
4492:
4490:
4486:
4482:
4479:
4477:
4473:
4469:
4465:
4461:
4457:
4454:
4453:
4452:
4449:
4448:
4446:
4444:
4440:
4430:
4427:
4425:
4421:
4418:
4417:
4412:
4409:
4407:
4404:
4402:
4399:
4398:
4397:
4396:CSF receptors
4393:
4392:
4390:
4386:
4378:
4375:
4373:
4369:
4365:
4362:
4361:
4360:
4357:
4356:
4354:
4352:
4348:
4342:
4339:
4337:
4334:
4332:
4329:
4325:
4321:
4318:
4316:
4312:
4309:
4307:
4304:
4303:
4302:
4299:
4298:
4296:
4294:
4290:
4284:
4281:
4277:
4273:
4270:
4268:
4264:
4261:
4260:
4259:
4256:
4255:
4253:
4251:
4247:
4239:
4236:
4234:
4231:
4229:
4225:
4222:
4220:
4216:
4212:
4208:
4205:
4203:
4199:
4195:
4191:
4188:
4187:
4186:
4183:
4182:
4180:
4178:
4174:
4171:
4169:
4165:
4162:
4160:
4156:
4146:
4143:
4140:
4138:
4135:
4132:
4130:
4127:
4124:
4123:
4121:
4117:
4111:
4108:
4105:
4103:
4100:
4097:
4095:
4092:
4089:
4087:
4084:
4081:
4079:
4076:
4073:
4071:
4068:
4065:
4063:
4060:
4057:
4055:
4052:
4049:
4047:
4044:
4041:
4039:
4036:
4033:
4031:
4028:
4025:
4023:
4020:
4017:
4015:
4012:
4009:
4007:
4004:
4001:
4000:
3998:
3994:
3988:
3985:
3982:
3980:
3977:
3974:
3972:
3969:
3966:
3964:
3961:
3958:
3956:
3953:
3950:
3948:
3945:
3942:
3940:
3937:
3934:
3932:
3929:
3926:
3924:
3921:
3918:
3916:
3913:
3910:
3909:
3907:
3903:
3900:
3898:
3894:
3884:
3881:
3879:
3876:
3872:
3869:
3868:
3866:
3862:
3859:
3858:
3856:
3855:
3853:
3849:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3816:
3813:
3811:
3808:
3807:
3806:
3803:
3802:
3800:
3798:
3794:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3734:
3731:
3730:
3728:
3726:
3722:
3719:
3716:
3711:
3707:
3703:
3696:
3691:
3689:
3684:
3682:
3677:
3676:
3673:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3477:
3475:
3471:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3271:
3269:
3265:
3259:
3256:
3254:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3198:
3195:
3193:
3190:
3189:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3117:
3114:
3112:
3108:
3105:
3103:
3100:
3096:
3093:
3091:
3088:
3087:
3086:
3083:
3081:
3078:
3074:
3071:
3069:
3066:
3065:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3024:
3021:
3020:
3018:
3014:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2925:
2921:
2918:
2916:
2913:
2912:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2889:
2886:
2884:
2881:
2879:
2876:
2875:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2847:
2844:
2842:
2839:
2838:
2837:
2834:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2800:
2797:
2795:
2792:
2791:
2790:
2787:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2760:
2757:
2755:
2752:
2748:
2745:
2743:
2740:
2738:
2735:
2734:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2704:
2702:
2698:
2692:
2689:
2687:
2684:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2565:
2562:
2560:
2557:
2556:
2555:
2552:
2548:
2545:
2543:
2540:
2539:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2471:
2468:
2466:
2463:
2462:
2461:
2458:
2456:
2453:
2451:
2448:
2446:
2443:
2441:
2438:
2436:
2433:
2431:
2428:
2427:
2425:
2421:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2339:
2336:
2334:
2331:
2329:
2326:
2324:
2321:
2319:
2316:
2314:
2311:
2310:
2309:
2306:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2277:
2274:
2272:
2269:
2268:
2267:
2264:
2262:
2259:
2257:
2254:
2252:
2249:
2247:
2244:
2242:
2239:
2237:
2234:
2232:
2229:
2227:
2224:
2220:
2217:
2215:
2212:
2210:
2207:
2205:
2202:
2200:
2197:
2195:
2192:
2191:
2190:
2187:
2183:
2180:
2178:
2175:
2173:
2170:
2169:
2168:
2165:
2163:
2160:
2156:
2153:
2151:
2148:
2146:
2143:
2142:
2141:
2138:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2116:
2113:
2111:
2108:
2106:
2103:
2101:
2098:
2096:
2093:
2091:
2088:
2087:
2085:
2081:
2075:
2072:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2050:
2048:
2045:
2043:
2040:
2039:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2001:
1998:
1996:
1993:
1991:
1988:
1986:
1983:
1982:
1981:
1978:
1976:
1973:
1971:
1968:
1966:
1963:
1961:
1958:
1956:
1953:
1951:
1948:
1946:
1943:
1941:
1938:
1936:
1933:
1929:
1926:
1924:
1921:
1920:
1919:
1916:
1914:
1911:
1909:
1906:
1904:
1901:
1899:
1896:
1894:
1891:
1889:
1886:
1884:
1881:
1879:
1876:
1874:
1871:
1869:
1866:
1864:
1861:
1859:
1856:
1854:
1851:
1849:
1846:
1842:
1839:
1837:
1834:
1833:
1832:
1829:
1827:
1824:
1822:
1819:
1817:
1814:
1810:
1807:
1805:
1802:
1800:
1797:
1795:
1792:
1791:
1790:
1787:
1785:
1782:
1780:
1777:
1773:
1770:
1769:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1741:
1738:
1736:
1733:
1731:
1728:
1727:
1726:
1723:
1721:
1718:
1714:
1711:
1709:
1706:
1704:
1701:
1699:
1696:
1694:
1691:
1690:
1689:
1686:
1685:
1683:
1679:
1674:
1670:
1666:
1659:
1654:
1652:
1647:
1645:
1640:
1639:
1636:
1627:
1623:
1619:
1615:
1611:
1607:
1602:
1598:
1594:
1589:
1584:
1581:(3): 445–55.
1580:
1576:
1572:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1540:(8): 609–20.
1539:
1535:
1530:
1526:
1522:
1517:
1512:
1509:(5): 621–31.
1508:
1504:
1500:
1495:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1458:
1454:
1450:
1445:
1440:
1437:(7): 4292–7.
1436:
1432:
1428:
1423:
1422:
1417:
1412:
1408:
1407:
1402:
1401:
1396:
1395:
1391:
1382:
1378:
1373:
1368:
1364:
1360:
1357:(1): 558–65.
1356:
1352:
1348:
1341:
1338:
1333:
1329:
1324:
1319:
1315:
1311:
1307:
1300:
1297:
1292:
1288:
1283:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1243:
1240:
1227:
1223:
1217:
1214:
1209:
1205:
1199:
1196:
1191:
1187:
1181:
1178:
1174:
1170:
1165:
1163:
1161:
1157:
1150:
1148:
1146:
1142:
1138:
1130:
1128:
1126:
1123:, which as a
1122:
1118:
1113:
1111:
1107:
1099:
1097:
1095:
1092:
1088:
1085:
1077:
1075:
1073:
1072:memory T cell
1069:
1065:
1061:
1057:
1053:
1048:
1046:
1045:
1040:
1036:
1031:
1027:
1023:
1019:
1015:
1007:
1005:
1003:
999:
995:
991:
987:
983:
979:
975:
974:OX40 receptor
971:
967:
963:
951:
946:
942:
938:
935:
931:
924:
922:
919:
915:
909:
906:
902:
898:
891:
889:
883:
879:
876:
870:
868:
862:
858:
855:
851:
844:
842:
836:
832:
829:
823:
821:
815:
811:
808:
806:RefSeq (mRNA)
804:
797:
796:
791:
787:
784:
778:
777:
772:
768:
765:
763:
759:
752:
748:
744:
741:
735:
734:
729:
725:
722:
720:
716:
709:
708:
703:
699:
696:
690:
689:
684:
680:
677:
675:
671:
668:
665:
663:
660:
656:
653:
649:
645:
638:
634:
629:
623:
620:
618:
615:
613:
610:
608:
605:
603:
602:viral process
600:
598:
595:
593:
590:
588:
585:
583:
580:
578:
575:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
522:
519:
517:
514:
512:
509:
507:
504:
502:
499:
497:
494:
493:
491:
488:
487:
481:
478:
476:
473:
471:
468:
467:
465:
462:
461:
458:
457:Gene ontology
454:
450:
438:
433:
429:
424:
421:
419:
415:
407:
402:
392:
389:
385:
382:
372:
368:
364:
360:
356:
352:
348:
344:
340:
337:apex of heart
336:
335:
332:
328:
323:
320:
319:
316:
314:
310:
308:
307:
303:
302:
299:
297:
293:
289:
285:
281:
273:
268:
264:
260:
255:
245:
241:
234:
227:
221:
214:
210:
204:
200:
196:
191:
187:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
130:
125:
118:
113:
108:
97:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
5766:
5732:Lestaurtinib
5723:
5693:
5631:Ritlecitinib
5563:Lestaurtinib
5510:Upadacitinib
5339:Fontolizumab
5330:
5315:
5294:
5283:Rontalizumab
5264:
5122:
5077:Pegacaristim
5068:
5027:
4997:
4990:M-CSF (CSF1)
4970:Mavrilimumab
4966:
4960:Sargramostim
4950:Molgramostim
4935:Ecogramostim
4931:
4904:Nartograstim
4875:
4868:G-CSF (CSF3)
4853:Peginesatide
4833:Epoetin zeta
4798:Epoetin beta
4793:Epoetin alfa
4764:
4584:IL 17 family
4144:
4136:
4128:
4109:
4101:
4093:
4085:
4077:
4069:
4061:
4053:
4045:
4037:
4029:
4021:
4013:
4005:
3986:
3978:
3970:
3962:
3954:
3952:Fas receptor
3946:
3938:
3935:
3930:
3922:
3914:
3897:TNF receptor
3186:
3106:
3084:
3062:
2909:
2872:
2835:
2788:
2758:
2731:
2625:
2553:
2459:
2307:
2036:
1788:
1609:
1605:
1578:
1574:
1537:
1533:
1506:
1502:
1468:(2): 150–8.
1465:
1461:
1434:
1430:
1405:
1399:
1354:
1350:
1340:
1313:
1309:
1299:
1256:
1252:
1242:
1230:. Retrieved
1226:the original
1216:
1207:
1198:
1189:
1180:
1134:
1131:Interactions
1114:
1103:
1081:
1049:
1042:
1011:
973:
969:
965:
961:
960:
885:
864:
838:
817:
793:
774:
750:
731:
705:
686:
666:
661:
516:cell surface
311:
304:
132:External IDs
83:
5742:Quizartinib
5737:Midostaurin
5626:Peficitinib
5588:Ruxolitinib
5583:Peficitinib
5538:Baricitinib
5500:Ruxolitinib
5495:Peficitinib
5490:Oclacitinib
5485:Momelotinib
5470:Baricitinib
5465:Abrocitinib
5373:Interleukin
5331:Antibodies:
5288:Sifalimumab
5273:Faralimomab
5268:Anifrolumab
5265:Antibodies:
5087:Romiplostim
5072:Eltrombopag
5041:SCF (c-Kit)
4967:Antibodies:
4955:Regramostim
4889:Lenograstim
4070:(TNFRSF13C)
4062:(TNFRSF13B)
4054:(TNFRSF12A)
4046:(TNFRSF11B)
4038:(TNFRSF11A)
4030:(TNFRSF10D)
4022:(TNFRSF10C)
4014:(TNFRSF10B)
4006:(TNFRSF10A)
1050:OX40 binds
341:granulocyte
110:Identifiers
5773:Categories
5727:Emfilermin
5578:Pacritinib
5480:Filgotinib
5446:inhibitors
5334:Emapalumab
5106:Interferon
5031:Agerafenib
5021:Mirimostim
5011:Lanimostim
4945:Milodistim
4894:Leridistim
4879:Filgrastim
4720:modulators
4145:(TNFRSF27)
4137:(TNFRSF25)
4129:(TNFRSF21)
4110:(TNFRSF19)
4102:(TNFRSF18)
4094:(TNFRSF17)
4086:(TNFRSF16)
4078:(TNFRSF14)
3963:(TNFRSF6B)
3923:(TNFRSF1B)
3915:(TNFRSF1A)
1671:(see also
1175:, May 2017
1151:References
1084:pathologic
353:lymph node
315:(ortholog)
270:1,214,153
257:1,211,340
153:HomoloGene
5752:Sunitinib
5747:Sorafenib
5656:ZM-449829
5646:WHI-P 154
5636:TCS-21311
5573:NSC-33994
5528:Atiprimod
5316:Agonists:
5298:Bifarcept
5123:Agonists:
5069:Agonists:
5001:Cilmostim
4998:Agonists:
4975:Namilumab
4932:Agonists:
4876:Agonists:
4765:Agonists:
4728:Chemokine
4429:prolactin
3987:(TNFRSF9)
3979:(TNFRSF8)
3971:(TNFRSF7)
3955:(TNFRSF6)
3947:(TNFRSF5)
3939:(TNFRSF4)
3931:(TNFRSF3)
1612:: 23–68.
1273:1946-6234
1117:agonistic
984:, unlike
888:NP_035789
867:NP_003318
841:NM_011659
820:NM_003327
652:Orthologs
161:GeneCards
5651:ZM-39923
5568:NSC-7908
5533:AZD-1480
5424:instead.
5404:instead.
5384:instead.
5360:instead.
5278:MEDI-545
5052:instead.
4980:Otilimab
4783:CNTO-530
4739:instead.
4658:TGF-beta
4159:JAK-STAT
4107:TAJ/TROY
1665:Proteins
1626:15771565
1597:11567634
1575:Immunity
1562:10503208
1554:12974476
1525:15894279
1503:Immunity
1490:10102422
1482:14730361
1453:15034043
1291:29386357
1171:–
1137:interact
1094:bird flu
1030:cytokine
1026:survivin
1008:Function
934:Wikidata
631:Sources:
501:membrane
373:appendix
5784:T cells
5593:SD-1008
4768:ARA-290
4654:Ser/Thr
4476:IL22RA2
4472:IL22RA1
4443:Type II
4372:IL12RB2
4368:IL12RB1
4351:IL12RB1
4250:β-chain
4219:IL13RA2
4215:IL13RA1
4177:γ-chain
3473:301–350
3267:251–300
3219:CD240CE
3016:201–250
2700:151–200
2423:101–150
1406:TNFRSF4
1400:TNFRSF4
1381:9418902
1332:9488716
1282:5997264
1232:6 April
1173:Ensembl
1108:, OX40-
1044:in vivo
982:T cells
966:TNFRSF4
762:UniProt
719:Ensembl
658:Species
637:QuickGO
290:pattern
249:1p36.33
165:TNFRSF4
124:TNFRSF4
117:Aliases
33:TNFRSF4
18:TNFRSF4
5687:Others
5553:CYT387
5543:CHZ868
5432:Others
5188:IFNA21
5184:IFNA17
5180:IFNA16
5176:IFNA14
5172:IFNA13
5168:IFNA10
4673:family
4668:TGFBR2
4663:TGFBR1
4617:IL17RE
4612:IL17RD
4607:IL17RC
4602:IL17RB
4597:IL17RA
4574:IL18R1
4527:IFNGR2
4523:IFNGR1
4514:IFNAR2
4510:IFNAR1
4489:IL20RB
4485:IL20RA
4464:IL10RB
4460:IL10RA
4394:other
4324:IL27RA
4315:IL11RA
4283:GM-CSF
4168:Type I
4051:TweakR
3883:CMKLR1
3861:CX3CR1
3480:CD300A
3439:CDw293
3224:CD240D
3085:CD213a
3063:CDw210
3028:CD202b
3002:CDw199
2997:CDw198
2651:CD140b
2083:51–100
1624:
1595:
1560:
1552:
1523:
1488:
1480:
1451:
1397:Human
1379:
1372:121523
1369:
1330:
1289:
1279:
1271:
1068:CTLA-4
1022:Bcl-XL
994:ligand
920:search
918:PubMed
795:P47741
776:P43489
674:Entrez
418:BioGPS
349:spleen
149:104512
141:600315
5227:IFNB3
5223:IFNB1
5164:IFNA8
5160:IFNA7
5156:IFNA6
5152:IFNA5
5148:IFNA4
5144:IFNA2
5140:IFNA1
4642:CSF1R
4570:IL18R
4563:IL1R2
4558:IL1R1
4494:IL28R
4481:IL20R
4468:IL22R
4456:IL10R
4406:G-CSF
4388:Other
4377:IL23R
4364:IL12R
4341:CNTFR
4306:IL6RA
4293:gp130
4276:IL5RA
4267:IL3RA
4238:IL21R
4228:IL7RA
4211:IL13R
4202:IL15R
4198:IL2RB
4194:IL2RA
4142:EDA2R
4119:21-27
4067:BAFFR
3996:11-20
3984:CD137
3936:CD134
3920:TNFR2
3912:TNFR1
3878:CCBP2
3857:CX3C
3851:Other
3842:CXCR7
3837:CXCR6
3832:CXCR5
3827:CXCR4
3822:CXCR3
3815:CXCR2
3810:CXCR1
3787:CCR10
3747:CCRL2
3737:CCRL1
3715:GPCRs
3660:CD350
3655:CD349
3650:CD344
3645:CD340
3640:CD339
3635:CD338
3630:CD337
3625:CD336
3620:CD335
3615:CD334
3610:CD333
3605:CD332
3600:CD331
3595:CD329
3590:CD328
3585:CD327
3580:CD326
3575:CD325
3570:CD324
3565:CD322
3560:CD321
3555:CD320
3550:CD318
3545:CD317
3540:CD316
3535:CD315
3530:CD314
3525:CD312
3520:CD309
3515:CD307
3510:CD306
3505:CD305
3500:CD304
3495:CD303
3490:CD302
3485:CD301
3464:CD299
3459:CD298
3454:CD297
3449:CD295
3444:CD294
3434:CD292
3429:CD290
3424:CD289
3419:CD288
3414:CD286
3409:CD284
3404:CD283
3399:CD282
3394:CD281
3389:CD280
3384:CD279
3379:CD278
3374:CD276
3369:CD275
3364:CD274
3359:CD273
3354:CD272
3349:CD271
3344:CD269
3339:CD268
3334:CD267
3329:CD266
3324:CD265
3319:CD264
3314:CD263
3309:CD262
3304:CD261
3299:CD258
3294:CD257
3289:CD256
3284:CD254
3279:CD253
3274:CD252
3258:CD249
3253:CD248
3249:CD247
3244:CD246
3239:CD244
3234:CD243
3229:CD241
3214:CD239
3209:CD238
3204:CD236
3187:CD235
3182:CD234
3177:CD233
3172:CD230
3167:CD229
3162:CD228
3157:CD227
3152:CD226
3147:CD225
3142:CD224
3137:CD223
3132:CD222
3127:CD221
3122:CD220
3107:CD218
3102:CD217
3080:CD212
3058:CD209
3053:CD208
3048:CD207
3043:CD206
3038:CD205
3033:CD204
3023:CD201
3007:CD200
2992:CD197
2987:CD196
2982:CD195
2977:CD194
2972:CD193
2967:CD192
2962:CD191
2957:CD186
2952:CD185
2947:CD184
2942:CD183
2937:CD182
2932:CD181
2927:CD180
2910:CD179
2905:CD178
2900:CD177
2895:CD174
2873:CD172
2868:CD171
2863:CD170
2858:CD169
2853:CD168
2836:CD167
2831:CD166
2826:CD164
2821:CD163
2816:CD162
2811:CD161
2806:CD160
2789:CD159
2759:CD158
2754:CD157
2732:CD156
2727:CD155
2722:CD154
2717:CD153
2712:CD152
2707:CD151
2691:CD150
2686:CD148
2681:CD147
2676:CD146
2671:CD144
2666:CD143
2661:CD142
2656:CD141
2646:CD138
2641:CD137
2636:CD136
2631:CD135
2626:CD134
2621:CD133
2616:CD132
2611:CD131
2606:CD130
2601:CD129
2596:CD127
2591:CD126
2586:CD125
2581:CD124
2576:CD123
2571:CD122
2554:CD121
2537:CD120
2532:CD119
2527:CD118
2522:CD117
2517:CD116
2512:CD115
2507:CD114
2502:CD113
2497:CD112
2492:CD111
2487:CD110
2482:CD109
2477:CD108
2460:CD107
2455:CD106
2450:CD105
2445:CD104
2440:CD103
2435:CD102
2430:CD101
2414:CD100
1558:S2CID
1486:S2CID
1145:TRAF2
1141:TRAF5
1139:with
1064:TRAF3
1060:TRAF5
1056:NF-κB
1052:TRAF2
1018:Bcl-2
998:OX40L
970:CD134
707:22163
667:Mouse
662:Human
633:Amigo
369:blood
345:gonad
313:Mouse
306:Human
253:Start
186:Human
5666:TYK2
5608:JAK3
5520:JAK2
5457:JAK1
5422:here
5420:See
5402:here
5400:See
5393:TGFβ
5382:here
5380:See
5358:here
5050:here
5048:See
4737:here
4735:See
4592:IL17
4506:-α/β
4336:LIFR
4331:OSMR
4272:IL5R
4263:IL3R
4233:IL9R
4224:IL7R
4207:IL4R
4190:IL2R
4099:GITR
4091:BCMA
4083:NGFR
4075:HVEM
4059:TACI
4035:RANK
4027:DcR2
4019:DcR1
3976:CD30
3968:CD27
3960:DcR3
3944:CD40
3928:LTBR
3905:1-10
3871:XCR1
3805:IL-8
3782:CCR9
3777:CCR8
3772:CCR7
3767:CCR6
3762:CCR5
3757:CCR4
3752:CCR3
3742:CCR2
3733:CCR1
2409:CD99
2404:CD98
2399:CD97
2394:CD96
2389:CD95
2384:CD94
2379:CD93
2374:CD92
2370:CD91
2365:CD90
2360:CD89
2355:CD88
2350:CD87
2345:CD86
2308:CD85
2303:CD84
2298:CD83
2293:CD82
2288:CD81
2283:CD80
2266:CD79
2261:CD78
2256:CD74
2251:CD73
2246:CD72
2241:CD71
2236:CD70
2231:CD69
2226:CD68
2189:CD66
2167:CD64
2162:CD63
2140:CD62
2135:CD61
2130:CD59
2125:CD58
2120:CD57
2115:CD56
2110:CD55
2105:CD54
2100:CD53
2095:CD52
2090:CD51
2074:CD50
2037:CD49
2032:CD48
2027:CD47
2022:CD46
2017:CD45
2012:CD44
2007:CD43
1980:CD42
1975:CD41
1970:CD40
1965:CD39
1960:CD38
1955:CD37
1950:CD36
1945:CD35
1940:CD34
1935:CD33
1918:CD32
1913:CD31
1908:CD30
1903:CD29
1898:CD28
1893:CD27
1888:CD26
1883:CD25
1878:CD24
1873:CD23
1868:CD22
1863:CD21
1858:CD20
1853:CD19
1848:CD18
1831:CD16
1826:CD15
1821:CD14
1816:CD13
1789:CD11
1784:CD10
1681:1–50
1622:PMID
1593:PMID
1550:PMID
1521:PMID
1478:PMID
1449:PMID
1377:PMID
1328:PMID
1287:PMID
1269:ISSN
1234:2016
1143:and
1125:TLR9
1091:H5N1
1037:and
1024:and
1014:CD4+
1002:CD28
986:CD28
978:TNFR
972:and
688:7293
296:Bgee
244:Band
203:Chr.
157:2496
137:OMIM
94:2HEY
90:2HEV
86:1D0A
67:RCSB
64:PDBe
5440:JAK
5413:TNF
4748:CSF
4647:KIT
4637:Tyr
4553:IL1
4401:EPO
4134:DR3
4126:DR6
4011:DR5
4003:DR4
3867:XC
3797:CXC
1779:CD9
1767:CD8
1762:CD7
1757:CD6
1752:CD5
1747:CD4
1725:CD3
1720:CD2
1693:a-c
1688:CD1
1614:doi
1583:doi
1542:doi
1511:doi
1470:doi
1439:doi
1435:172
1367:PMC
1359:doi
1318:doi
1314:273
1277:PMC
1261:doi
1039:Th2
1035:Th1
911:n/a
751:n/a
393:n/a
266:End
169:OMA
145:MGI
57:PDB
5775::
5225:,
5186:,
5182:,
5178:,
5174:,
5170:,
5166:,
5162:,
5158:,
5154:,
5150:,
5146:,
5142:,
4656::
4572:/
4525:/
4519:-γ
4508:/
4487:/
4483:/
4474:/
4470:/
4466:/
4462:/
4458:/
4424:GH
4422::
4320:27
4311:11
4274:/
4265:/
4226:/
4217:/
4213:/
4209:/
4200:/
4192:/
3735:/
3725:CC
3251:-
2372:-
1713:1E
1708:1D
1703:1B
1698:1A
1667::
1620:.
1610:23
1608:.
1591:.
1579:15
1577:.
1573:.
1556:.
1548:.
1536:.
1519:.
1507:22
1505:.
1501:.
1484:.
1476:.
1464:.
1447:.
1433:.
1429:.
1375:.
1365:.
1355:18
1353:.
1349:.
1326:.
1312:.
1308:.
1285:.
1275:.
1267:.
1257:10
1255:.
1251:.
1206:.
1188:.
1159:^
1147:.
1096:.
1047:.
1020:,
996:,
635:/
272:bp
259:bp
167:;
163::
159:;
155::
151:;
147::
143:;
139::
92:,
88:,
5448:)
5444:(
5229:)
5221:(
5190:)
5138:(
4709:e
4702:t
4695:v
4521:/
4512:/
4370:/
4366:/
4322:/
4313:/
4196:/
3717:)
3713:(
3694:e
3687:t
3680:v
3197:b
3192:a
3118:)
3116:b
3111:a
3109:(
3095:2
3090:1
3073:b
3068:a
2920:b
2915:a
2888:g
2883:b
2878:a
2846:b
2841:a
2799:c
2794:a
2785:)
2783:k
2778:i
2773:e
2768:d
2763:a
2761:(
2747:c
2742:b
2737:a
2564:b
2559:a
2547:b
2542:a
2470:b
2465:a
2338:k
2333:j
2328:h
2323:e
2318:d
2313:a
2276:b
2271:a
2219:f
2214:e
2209:d
2204:c
2199:b
2194:a
2182:C
2177:B
2172:A
2155:P
2150:L
2145:E
2067:f
2062:e
2057:d
2052:c
2047:b
2042:a
2000:d
1995:c
1990:b
1985:a
1928:B
1923:A
1841:B
1836:A
1809:d
1804:c
1799:b
1794:a
1772:a
1740:ε
1735:δ
1730:γ
1675:)
1657:e
1650:t
1643:v
1628:.
1616::
1599:.
1585::
1564:.
1544::
1538:3
1527:.
1513::
1492:.
1472::
1466:5
1455:.
1441::
1413:.
1383:.
1361::
1334:.
1320::
1293:.
1263::
1236:.
1210:.
1192:.
964:(
188:)
171::
20:)
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