289:
266:
163:
188:
295:
194:
1551:
50:
302:
201:
804:
785:
124:
1592:
1209:
1191:
1611:
288:
1348:
Yu G, Boone T, Delaney J, et al. (2001). "APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity".
1015:
265:
1430:"BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases"
1008:
1230:
1315:"Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS"
1178:
1157:
301:
200:
187:
162:
1292:
Kelly K, Manos E, Jensen G, et al. (2000). "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death".
1174:
294:
193:
1153:
1387:"Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase"
1585:
1112:-binding domain of the family member 13 at the cell surface. It stimulates cycling in T-lymphoma and B-lymphoma
849:
112:
47:
1109:
830:
1616:
1578:
1121:
176:
132:
99:
946:
942:
938:
1465:"An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK–APRIL fusion protein"
1373:
136:
972:
917:
1529:
1494:
1451:
1416:
1365:
1336:
1301:
1280:
1231:"Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13"
1101:
92:
40:
1519:
1484:
1476:
1441:
1406:
1398:
1357:
1326:
1270:
1262:
1105:
381:
312:
256:
211:
356:
1562:
1411:
1386:
1275:
1251:"APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth"
1250:
1508:"Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation"
1489:
1464:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
633:
628:
623:
618:
613:
608:
603:
587:
582:
577:
572:
1605:
1097:
559:
116:
1377:
374:
153:
1402:
140:
1446:
1429:
1214:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1196:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1093:
457:
273:
170:
120:
1129:
1113:
749:
517:
395:
340:
327:
239:
226:
128:
1533:
1524:
1507:
1498:
1480:
1455:
1420:
1369:
1340:
1331:
1314:
1305:
1266:
1284:
1055:
1050:
1085:
1039:
875:
1558:
1125:
1089:
861:
816:
1550:
69:
1023:
771:
1361:
1082:
734:
730:
1117:
1075:
1506:
Hendriks J, Planelles L, de Jong-Odding J, et al. (2005).
1463:
Pradet-Balade B, Medema JP, López-Fraga M, et al. (2002).
1068:
Tumor necrosis factor (ligand) superfamily, member 12-member 13
700:
positive regulation of extrinsic apoptotic signaling pathway
364:
1566:
1428:
Roschke V, Sosnovtseva S, Ward CD, et al. (2002).
1385:
López-Fraga M, Fernández R, Albar JP, Hahne M (2002).
655:
positive regulation of endothelial cell proliferation
529:
1249:
Hahne M, Kataoka T, Schröter M, et al. (1998).
1313:Wu Y, Bressette D, Carrell JA, et al. (2001).
986:
965:
931:
910:
1170:
1168:
1166:
1149:
1147:
1145:
311:
210:
1088:factor superfamily (TNFSF). It encodes a hybrid
670:tumor necrosis factor-mediated signaling pathway
660:positive regulation of protein catabolic process
1104:of the family member 13. The hybrid protein is
16:Protein-coding gene in the species Homo sapiens
1175:GRCm38: Ensembl release 89: ENSMUSG00000018752
1586:
1100:domains of the family member 12 fused to the
8:
1154:GRCh38: Ensembl release 89: ENSG00000248871
1593:
1579:
745:
555:
352:
251:
148:
58:
1523:
1488:
1445:
1410:
1330:
1274:
720:regulation of signaling receptor activity
1225:
1223:
1141:
103:, TWE-PRIL, TNFSF12-TNFSF13 readthrough
583:tumor necrosis factor receptor binding
18:
665:extrinsic apoptotic signaling pathway
619:integral component of plasma membrane
316:
277:
272:
215:
174:
169:
7:
1547:
1545:
675:positive regulation of angiogenesis
983:
962:
928:
907:
885:
866:
840:
821:
795:
776:
680:multicellular organism development
534:
452:
390:
369:
14:
1549:
300:
293:
287:
264:
199:
192:
186:
161:
629:perinuclear region of cytoplasm
604:integral component of membrane
518:More reference expression data
406:olfactory zone of nasal mucosa
1:
285:
184:
1612:Genes on human chromosome 17
1565:. You can help Knowledge by
1120:transcript is expressed and
1447:10.4049/jimmunol.169.8.4314
1403:10.1093/embo-reports/kve198
695:apoptotic signaling pathway
430:subcutaneous adipose tissue
418:stromal cell of endometrium
141:TNFSF12-TNFSF13 - orthologs
1633:
1544:
705:endothelial cell migration
588:signaling receptor binding
1210:"Mouse PubMed Reference:"
1192:"Human PubMed Reference:"
1081:This gene belongs to the
1054:
1049:
1045:
1038:
1022:
1003:
990:
969:
958:
935:
914:
903:
892:
888:
873:
869:
860:
847:
843:
828:
824:
815:
802:
798:
783:
779:
770:
755:
748:
744:
728:
558:
554:
542:
537:
528:
515:
480:quadriceps femoris muscle
464:
455:
402:
393:
363:
355:
351:
334:
321:
284:
263:
254:
250:
233:
220:
183:
160:
151:
147:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1016:Chr 11: 69.57 – 69.59 Mb
1561:-related article is a
1525:10.1038/sj.cdd.4401647
1332:10.1074/jbc.M005224200
1267:10.1084/jem.188.6.1185
1009:Chr 17: 7.55 – 7.56 Mb
468:neural layer of retina
45:Human UniProt search:
434:right coronary artery
279:Chromosome 11 (mouse)
177:Chromosome 17 (human)
1481:10.1093/emboj/cdf565
650:cell differentiation
624:extracellular region
62:List of PDB id codes
35:Available structures
710:signal transduction
634:extracellular space
850:ENSMUSG00000018752
643:Biological process
597:Cellular component
566:Molecular function
1574:
1573:
1512:Cell Death Differ
1108:and presents the
1106:membrane anchored
1102:C-terminal domain
1065:
1064:
1061:
1060:
1034:
1033:
999:
998:
980:
979:
954:
953:
925:
924:
899:
898:
882:
881:
856:
855:
837:
836:
811:
810:
792:
791:
740:
739:
715:apoptotic process
573:cytokine activity
550:
549:
546:
545:
524:
523:
511:
510:
449:
448:
347:
346:
246:
245:
81:
80:
77:
76:
1624:
1595:
1588:
1581:
1553:
1546:
1537:
1527:
1502:
1492:
1459:
1449:
1424:
1414:
1381:
1344:
1334:
1325:(45): 35478–85.
1309:
1288:
1278:
1235:
1234:
1227:
1218:
1217:
1206:
1200:
1199:
1188:
1182:
1172:
1161:
1151:
1092:composed of the
1070:, also known as
1047:
1046:
1018:
1011:
994:
984:
975:
963:
959:RefSeq (protein)
949:
929:
920:
908:
886:
867:
841:
822:
796:
777:
746:
556:
535:
520:
460:
458:Top expressed in
453:
398:
396:Top expressed in
391:
370:
353:
343:
330:
319:
304:
297:
291:
280:
268:
252:
242:
229:
218:
203:
196:
190:
179:
165:
149:
143:
102:
95:
72:
59:
53:
32:
31:
19:
1632:
1631:
1627:
1626:
1625:
1623:
1622:
1621:
1602:
1601:
1600:
1599:
1542:
1540:
1505:
1475:(21): 5711–20.
1462:
1427:
1384:
1347:
1312:
1291:
1248:
1244:
1242:Further reading
1239:
1238:
1229:
1228:
1221:
1208:
1207:
1203:
1190:
1189:
1185:
1173:
1164:
1152:
1143:
1138:
1072:TNFSF12-TNFSF13
1056:View/Edit Mouse
1051:View/Edit Human
1014:
1007:
1004:Location (UCSC)
992:
971:
945:
941:
937:
916:
831:ENSG00000248871
724:
690:immune response
638:
614:plasma membrane
592:
578:protein binding
516:
507:
504:muscle of thigh
502:
498:
494:
490:
486:
482:
478:
474:
470:
456:
445:
440:
436:
432:
428:
424:
420:
416:
412:
408:
394:
338:
325:
317:
307:
306:
305:
298:
278:
255:Gene location (
237:
224:
216:
206:
205:
204:
197:
175:
152:Gene location (
133:TNFSF12-TNFSF13
111:
100:TNFSF12-TNFSF13
98:
91:
68:
46:
22:TNFSF12-TNFSF13
17:
12:
11:
5:
1630:
1628:
1620:
1619:
1614:
1604:
1603:
1598:
1597:
1590:
1583:
1575:
1572:
1571:
1554:
1539:
1538:
1503:
1460:
1440:(8): 4314–21.
1425:
1397:(10): 945–51.
1382:
1345:
1310:
1289:
1261:(6): 1185–90.
1245:
1243:
1240:
1237:
1236:
1219:
1201:
1183:
1162:
1140:
1139:
1137:
1134:
1063:
1062:
1059:
1058:
1053:
1043:
1042:
1036:
1035:
1032:
1031:
1029:
1027:
1020:
1019:
1012:
1005:
1001:
1000:
997:
996:
988:
987:
981:
978:
977:
967:
966:
960:
956:
955:
952:
951:
933:
932:
926:
923:
922:
912:
911:
905:
901:
900:
897:
896:
890:
889:
883:
880:
879:
871:
870:
864:
858:
857:
854:
853:
845:
844:
838:
835:
834:
826:
825:
819:
813:
812:
809:
808:
800:
799:
793:
790:
789:
781:
780:
774:
768:
767:
762:
757:
753:
752:
742:
741:
738:
737:
726:
725:
723:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
646:
644:
640:
639:
637:
636:
631:
626:
621:
616:
611:
606:
600:
598:
594:
593:
591:
590:
585:
580:
575:
569:
567:
563:
562:
552:
551:
548:
547:
544:
543:
540:
539:
532:
526:
525:
522:
521:
513:
512:
509:
508:
506:
505:
501:
497:
493:
489:
485:
481:
477:
473:
469:
465:
462:
461:
450:
447:
446:
444:
443:
442:thoracic aorta
439:
435:
431:
427:
426:gastric mucosa
423:
419:
415:
411:
407:
403:
400:
399:
387:
386:
378:
367:
361:
360:
357:RNA expression
349:
348:
345:
344:
336:
332:
331:
323:
320:
315:
309:
308:
299:
292:
286:
282:
281:
276:
270:
269:
261:
260:
248:
247:
244:
243:
235:
231:
230:
222:
219:
214:
208:
207:
198:
191:
185:
181:
180:
173:
167:
166:
158:
157:
145:
144:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1629:
1618:
1617:Protein stubs
1615:
1613:
1610:
1609:
1607:
1596:
1591:
1589:
1584:
1582:
1577:
1576:
1570:
1568:
1564:
1560:
1555:
1552:
1548:
1543:
1535:
1531:
1526:
1521:
1518:(6): 637–48.
1517:
1513:
1509:
1504:
1500:
1496:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1461:
1457:
1453:
1448:
1443:
1439:
1435:
1431:
1426:
1422:
1418:
1413:
1408:
1404:
1400:
1396:
1392:
1388:
1383:
1379:
1375:
1371:
1367:
1363:
1362:10.1038/79802
1359:
1355:
1351:
1346:
1342:
1338:
1333:
1328:
1324:
1320:
1319:J. Biol. Chem
1316:
1311:
1307:
1303:
1300:(4): 1021–7.
1299:
1295:
1290:
1286:
1282:
1277:
1272:
1268:
1264:
1260:
1256:
1252:
1247:
1246:
1241:
1232:
1226:
1224:
1220:
1215:
1211:
1205:
1202:
1197:
1193:
1187:
1184:
1180:
1176:
1171:
1169:
1167:
1163:
1159:
1155:
1150:
1148:
1146:
1142:
1135:
1133:
1131:
1127:
1123:
1119:
1115:
1111:
1107:
1103:
1099:
1098:transmembrane
1095:
1091:
1087:
1084:
1079:
1077:
1074:, is a human
1073:
1069:
1057:
1052:
1048:
1044:
1041:
1037:
1030:
1028:
1025:
1021:
1017:
1013:
1010:
1006:
1002:
995:
989:
985:
982:
976:
974:
968:
964:
961:
957:
950:
948:
944:
940:
934:
930:
927:
921:
919:
913:
909:
906:
904:RefSeq (mRNA)
902:
895:
891:
887:
884:
878:
877:
872:
868:
865:
863:
859:
852:
851:
846:
842:
839:
833:
832:
827:
823:
820:
818:
814:
807:
806:
801:
797:
794:
788:
787:
782:
778:
775:
773:
769:
766:
763:
761:
758:
754:
751:
747:
743:
736:
732:
727:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
647:
645:
642:
641:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
589:
586:
584:
581:
579:
576:
574:
571:
570:
568:
565:
564:
561:
560:Gene ontology
557:
553:
541:
536:
533:
531:
527:
519:
514:
503:
499:
495:
492:adrenal gland
491:
488:muscle tissue
487:
483:
479:
475:
471:
467:
466:
463:
459:
454:
451:
441:
437:
433:
429:
425:
421:
417:
413:
409:
405:
404:
401:
397:
392:
389:
388:
385:
383:
379:
377:
376:
372:
371:
368:
366:
362:
358:
354:
350:
342:
337:
333:
329:
324:
318:11|11 B3
314:
310:
303:
296:
290:
283:
275:
271:
267:
262:
258:
253:
249:
241:
236:
232:
228:
223:
213:
209:
202:
195:
189:
182:
178:
172:
168:
164:
159:
155:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
1567:expanding it
1556:
1541:
1515:
1511:
1472:
1468:
1437:
1433:
1394:
1390:
1356:(3): 252–6.
1353:
1350:Nat. Immunol
1349:
1322:
1318:
1297:
1293:
1258:
1254:
1213:
1204:
1195:
1186:
1080:
1071:
1067:
1066:
991:
970:
947:NM_001159503
943:NM_001034098
939:NM_001034097
936:
915:
893:
874:
848:
829:
803:
784:
764:
759:
685:angiogenesis
500:right kidney
438:renal cortex
380:
373:
108:External IDs
67:
1255:J. Exp. Med
1124:in primary
1094:cytoplasmic
496:bone marrow
410:granulocyte
339:69,586,924
326:69,573,403
86:Identifiers
1606:Categories
1434:J. Immunol
1294:Cancer Res
1181:, May 2017
1160:, May 2017
1136:References
1122:translated
1114:cell lines
384:(ortholog)
238:7,561,601
225:7,549,099
121:HomoloGene
1130:monocytes
973:NP_003800
918:NM_172089
750:Orthologs
129:GeneCards
1534:15846369
1499:12411489
1456:12370363
1421:11571266
1391:EMBO Rep
1370:10973284
1341:10956646
1306:10706119
1177:–
1156:–
1110:receptor
1086:necrosis
1040:Wikidata
729:Sources:
609:membrane
484:duodenum
422:monocyte
1559:protein
1412:1084076
1378:6799584
1285:9743536
1276:2212534
1179:Ensembl
1158:Ensembl
1126:T cells
1090:protein
862:UniProt
817:Ensembl
756:Species
735:QuickGO
359:pattern
217:17p13.1
117:3845075
93:Aliases
1532:
1497:
1490:131062
1487:
1469:EMBO J
1454:
1419:
1409:
1376:
1368:
1339:
1304:
1283:
1273:
1116:. The
1026:search
1024:PubMed
876:O43508
805:619441
786:407977
772:Entrez
530:BioGPS
125:123930
1557:This
1374:S2CID
1083:tumor
765:Mouse
760:Human
731:Amigo
476:ovary
414:blood
382:Mouse
375:Human
322:Start
257:Mouse
221:Start
154:Human
1563:stub
1530:PMID
1495:PMID
1452:PMID
1417:PMID
1366:PMID
1337:PMID
1302:PMID
1281:PMID
1128:and
1118:mRNA
1096:and
1076:gene
472:lung
365:Bgee
313:Band
274:Chr.
212:Band
171:Chr.
70:4HT1
51:RCSB
48:PDBe
1520:doi
1485:PMC
1477:doi
1442:doi
1438:169
1407:PMC
1399:doi
1358:doi
1327:doi
1323:275
1271:PMC
1263:doi
1259:188
993:n/a
894:n/a
538:n/a
335:End
234:End
137:OMA
113:MGI
41:PDB
1608::
1528:.
1516:12
1514:.
1510:.
1493:.
1483:.
1473:21
1471:.
1467:.
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1165:^
1144:^
1132:.
1078:.
733:/
341:bp
328:bp
240:bp
227:bp
135:;
131::
127:;
123::
119:;
115::
1594:e
1587:t
1580:v
1569:.
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1401::
1395:2
1380:.
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139::
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