327:
304:
201:
226:
1309:
2717:
578:
42:
333:
232:
2702:
1248:
CD40 ligand (CD154) is primarily expressed on activated CD4+ T lymphocytes but is also found in a soluble form. While CD40L was originally described on T lymphocytes, its expression has since been found on a wide variety of cells, including platelets, mast cells, macrophages, basophils, NK cells, B
68:
1635:
Lederman S, Yellin MJ, Cleary AM, Pernis A, Inghirami G, Cohn LE, et al. (March 1994). "T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death".
1230:
generated a murine monoclonal antibody, 5c8, that inhibited contact-dependent T cell helper function in human cells and which characterized a 32 kDa surface protein transiently expressed on activated CD4+ T cells. Richard
Armitage at
1239:
generated an antibody that bound a 39 kDa protein on murine T cells and inhibited helper function. Noelle contested
Lederman's patent, but the challenge (called an interference) was rejected on all counts
1374:. The end-result is a B cell that is able to mass-produce specific antibodies against an antigenic target. Early evidence for these effects were that in CD40 or CD154 deficient mice, there is little
6125:
3618:
1596:"Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help"
5909:
2038:
Cleary AM, Fortune SM, Yellin MJ, Chess L, Lederman S (October 1995). "Opposing roles of CD95 (Fas/APO-1) and CD40 in the death and rescue of human low density tonsillar B cells".
2757:
1194:
maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo
1742:
Armitage RJ, Fanslow WC, Strockbine L, Sato TA, Clifford KN, Macduff BM, et al. (May 1992). "Molecular and biological characterization of a murine ligand for CD40".
340:
239:
6141:
5298:
6603:
2716:
6069:
3608:
6191:
6623:
1227:
6251:
5902:
3588:
1347:
recognizes the peptide presented by the B cell, the CD40L on the T cell binds to the B cell's CD40, causing B cell activation. The T cell also produces
876:
4450:
2774:
2750:
857:
162:
6594:
6583:
6559:
6049:
5374:
4181:
5938:
5769:
4169:
3947:
6085:
5895:
4233:
4228:
4174:
3954:
2735:
2681:
2600:
1527:
2224:"Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy"
6983:
6978:
6217:
3687:
3613:
2743:
1852:
1509:
4794:
4716:
4711:
4706:
4701:
3628:
2636:
1076:
326:
5949:
6903:
5660:
4681:
2464:
2293:
1083:
303:
1695:"Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help)"
1547:"Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help)"
1261:
priming and activation of CD40-expressing immune cells. At least 46 disease-causing mutations in this gene have been discovered.
3917:
2517:
Kornbluth RS (October 2002). "An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection".
1679:
5190:
4485:
3979:
3665:
2701:
1496:
1475:
1351:, which directly influences B cells. As a result of this stimulation, the B cell can undergo rapid cellular division to form a
6614:
6316:
4124:
3660:
1195:
2642:
1492:
225:
200:
65:
4967:
4621:
4093:
4088:
4033:
3767:
3216:
2583:
Law CL, Grewal IS (2009). "Therapeutic
Interventions Targeting CD40L (CD154) and CD40: The Opportunities and Challenges".
2081:
Grewal IS, Xu J, Flavell RA (December 1995). "Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand".
1983:"Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases"
1471:
6918:
4315:
4038:
142:
1166:(APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40,
5803:
5353:
5128:
3633:
1443:
1340:
1332:
1179:
339:
238:
1795:"A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells"
2303:
Tong AW, Stone MJ (March 1996). "CD40 and the effect of anti-CD40-binding on human multiple myeloma clonogenicity".
6908:
6550:
5836:
5638:
5348:
4345:
2770:
332:
231:
1296:
receptors on its surface, which helps increase the level of activation. The activated macrophage can then destroy
6509:
5979:
5757:
5442:
3211:
2674:
1249:
lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells).
1236:
5792:
5219:
5195:
4395:
3290:
2629:
1163:
921:
150:
6262:
5958:
4787:
4359:
1399:
902:
5974:
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3692:
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1411:
1293:
1211:
2654:
6459:
6454:
6405:
3046:
2964:
2410:
Bhushan A, Covey LR (2002). "CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes".
2333:
6044:
2655:
GeneReviews/NCBI/NIH/UW entry on X-Linked Hyper IgM Syndrome or
Immunodeficiency with Hyper-IgM, Type 1
2484:"CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection"
1171:
6059:
6574:
6410:
6115:
6009:
5646:
4283:
3996:
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1994:
1806:
1751:
214:
129:
6817:
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6024:
6019:
6014:
6004:
5488:
4310:
4129:
2648:
1363:
1207:
6278:
6136:
6105:
1235:
cloned a cDNA encoding CD154 by screening an expression library with CD40-Ig. Randolph Noelle at
6439:
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6400:
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6341:
6156:
5929:
5921:
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5612:
5527:
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174:
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1863:
1308:
1059:
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1012:
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6857:
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6734:
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2010:
2002:
1955:
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1814:
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1607:
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1558:
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419:
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5337:
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5327:
5322:
5270:
5255:
5246:
4803:
4335:
3757:
3268:
3071:
2248:
2223:
2199:
2174:
2150:
2133:
2015:
1982:
1719:
1694:
1571:
1546:
1167:
1159:
1257:
CD40L plays a central role in costimulation and regulation of the immune response via
1174:. CD154 acts as a costimulatory molecule and is particularly important on a subset of
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
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6110:
6029:
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5857:
5852:
5798:
5747:
5413:
5317:
5293:
5288:
5265:
5260:
5251:
5242:
5024:
4305:
3762:
2853:
2575:
1959:
1829:
1794:
1371:
1348:
1328:
1223:
606:
2546:
Xu Y, Song G (2005). "The role of CD40-CD154 interaction in cell immunoregulation".
2439:
2402:
2365:
2173:
Wang JH, Zhang YW, Zhang P, Deng BQ, Ding S, Wang ZK, et al. (September 2013).
2132:
Szmitko PE, Wang CH, Weisel RD, de
Almeida JR, Anderson TJ, Verma S (October 2003).
2067:
1932:
1665:
6933:
6913:
6832:
6822:
6764:
6711:
6641:
6540:
6484:
6171:
6161:
6151:
6054:
6034:
5999:
5994:
5343:
5175:
4661:
3969:
3959:
3490:
3456:
2190:
2118:
1779:
1297:
412:
191:
1793:
Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A (July 1992).
154:
1680:"Entrez Gene: CD40LG CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)"
1612:
1595:
1594:
Lederman S, Yellin MJ, Inghirami G, Lee JJ, Knowles DM, Chess L (December 1992).
178:
6943:
6938:
6842:
6827:
6799:
6789:
6784:
6739:
6706:
6701:
6696:
6691:
6686:
6671:
6666:
6489:
6474:
6469:
6288:
6273:
6090:
5764:
5710:
5451:
5210:
5133:
4671:
4320:
4098:
4073:
3772:
3394:
3320:
2794:
2592:
2239:
2051:
1649:
1532:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1514:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1367:
133:, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand
5887:
2725:: STRUCTURE OF CD40L IN COMPLEX WITH THE FAB FRAGMENT OF HUMANIZED 5C8 ANTIBODY
2587:. Advances in Experimental Medicine and Biology. Vol. 647. pp. 8–36.
2530:
2006:
1799:
Proceedings of the
National Academy of Sciences of the United States of America
1434:. CD40L has shown to be a potential biomarker for atherosclerotic instability.
495:
6779:
6681:
6535:
6080:
5817:
5510:
5200:
5160:
4601:
4325:
4006:
3747:
3623:
3256:
3251:
3246:
3101:
2885:
2423:
2386:
2316:
2222:
Lineberry NB, Su LL, Lin JT, Coffey GP, Seroogy CM, Fathman CG (August 2008).
1415:
1289:
1270:
311:
208:
158:
6953:
6948:
6729:
6176:
4822:
4772:
4440:
4435:
4430:
4420:
4415:
4410:
4405:
1819:
1693:
Lederman S, Yellin MJ, Krichevsky A, Belko J, Lee JJ, Chess L (April 1992).
1545:
Lederman S, Yellin MJ, Krichevsky A, Belko J, Lee JJ, Chess L (April 1992).
1403:
821:
555:
433:
378:
365:
277:
264:
166:
2610:
2567:
2538:
2509:
2474:
2431:
2394:
2357:
2257:
2208:
2159:
2024:
1924:
1710:
1562:
2324:
2110:
2059:
1967:
1946:
Grewal IS, Flavell RA (1998). "CD40 and CD154 in cell-mediated immunity".
1838:
1771:
1728:
1657:
1621:
1580:
1426:. This inflammatory reaction in endothelial cells promotes recruitment of
1316:(right), and several interaction molecules, the TH2-cell expressing CD40L.
1123:
1118:
6181:
5812:
4807:
4746:
4646:
4460:
4445:
3648:
3643:
3551:
3241:
1407:
1395:
1356:
1324:
1107:
966:
947:
2373:
Schattner EJ (May 2000). "CD40 ligand in CLL pathogenesis and therapy".
4696:
4691:
4686:
4586:
4400:
4390:
4217:
4196:
4191:
4159:
3964:
3884:
3879:
3874:
3869:
3864:
3782:
3475:
3315:
3310:
3305:
3300:
3295:
2766:
2349:
1905:
1151:
1147:
933:
888:
2559:
2456:
2175:"CD40 ligand as a potential biomarker for atherosclerotic instability"
99:
95:
91:
87:
17:
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3414:
3283:
3278:
3273:
3221:
3206:
3076:
3066:
3029:
3024:
2942:
2937:
2134:"New markers of inflammation and endothelial cell activation: Part I"
2102:
1763:
1447:
1423:
1419:
1320:
1313:
1281:
1258:
1191:
1175:
1091:
843:
2447:
Cheng G, Schoenberger SP (2002). "CD40 signaling and autoimmunity".
2500:
2483:
2451:. Current Directions in Autoimmunity. Vol. 5. pp. 51–61.
6424:
6365:
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4354:
4350:
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4253:
4154:
4149:
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4001:
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3153:
3148:
3143:
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2895:
1292:
cell surface. As a result, the macrophage expresses more CD40 and
1232:
806:
802:
6809:
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5650:
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5106:
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3019:
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2932:
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2922:
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2831:
2814:
2809:
2804:
2799:
1285:
146:
5891:
4776:
2739:
2663:
1312:
T cell-dependent B cell activation, showing a TH2-cell (left),
4268:
2880:
2868:
2863:
2858:
2848:
2821:
2789:
2659:
1278:
772:
positive regulation of NF-kappaB transcription factor activity
586:
1284:. The secondary signal is CD40L on the T cell, which binds
732:
positive regulation of endothelial cell apoptotic process
1382:
formation, and immune responses are severely inhibited.
402:
6050:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
567:
6888:
6866:
6808:
6720:
6657:
6640:
6633:
6613:
6593:
6573:
6549:
6508:
6315:
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6261:
6241:
6190:
6124:
6068:
5957:
5948:
5928:
5782:
5740:
5709:
5637:
5611:
5518:
5509:
5450:
5441:
5406:
5369:
5307:
5279:
5233:
5218:
5209:
5119:
5094:
5078:
4981:
4830:
4821:
4814:
4574:
4368:
4117:
3801:
3524:
3184:
2782:
1222:In 1991, three groups reported discovering CD154.
1052:
1031:
1005:
984:
2277:
1488:
1486:
1484:
1467:
1465:
1463:
2519:Journal of Hematotherapy & Stem Cell Research
349:
248:
6142:Granulocyte macrophage colony-stimulating factor
782:positive regulation of interleukin-10 production
722:tumor necrosis factor-mediated signaling pathway
712:positive regulation of interleukin-12 production
1202:. Absence of CD154 also stops the formation of
777:positive regulation of interleukin-4 production
1493:GRCm38: Ensembl release 89: ENSMUSG00000031132
5903:
4788:
2751:
2675:
8:
2449:Signal Transduction Pathways in Autoimmunity
1366:occurs, as well as their differentiation to
1472:GRCh38: Ensembl release 89: ENSG00000102245
787:positive regulation of T cell proliferation
6909:Leukemia/leukocyte inhibitory factor (LIF)
6654:
6637:
6312:
5954:
5910:
5896:
5888:
5515:
5447:
5230:
5215:
4827:
4818:
4795:
4781:
4773:
2758:
2744:
2736:
2682:
2668:
2660:
2585:Therapeutic Targets of the TNF Superfamily
2284:(2nd ed.). Garland Science. pp.
817:
602:
390:
289:
186:
76:
6904:FMS-like tyrosine kinase 3 ligand (FLT3L)
6333:Interferon alpha (interferon alfa, IFN-α)
2775:list of human clusters of differentiation
2628:at the U.S. National Library of Medicine
2499:
2247:
2198:
2149:
2014:
1981:Šimčíková D, Heneberg P (December 2019).
1914:
1904:
1860:UNITED STATES PATENT AND TRADEMARK OFFICE
1828:
1818:
1718:
1611:
1570:
1150:that is primarily expressed on activated
792:regulation of signaling receptor activity
6926:Additional cytokine receptor modulators:
2710:: CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND
1307:
717:negative regulation of apoptotic process
2697:
1459:
1430:to lesions and may potentially promote
1273:, the primary signal for activation is
1226:, Michael Yellin, and Leonard Chess at
6750:Cucurbitacin I (elatericin B, JSI-124)
630:tumor necrosis factor receptor binding
31:
6086:Granulocyte colony-stimulating factor
1889:"The CD40/CD154 receptor/ligand dyad"
1887:Schönbeck U, Libby P (January 2001).
1300:bacteria and produce more cytokines.
666:integral component of plasma membrane
354:
315:
310:
253:
212:
207:
7:
6445:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
6218:Macrophage colony-stimulating factor
2336:(January 2000). "CD40-CD40 ligand".
1893:Cellular and Molecular Life Sciences
1862:. U.S. Patent Office. Archived from
1699:The Journal of Experimental Medicine
1551:The Journal of Experimental Medicine
6919:Thymic stromal lymphopoietin (TSLP)
1206:and therefore prohibiting antibody
2488:The Journal of Infectious Diseases
2151:10.1161/01.CIR.0000089190.95415.9F
1049:
1028:
1002:
981:
957:
938:
912:
893:
867:
848:
681:intracellular anatomical structure
572:
490:
428:
407:
25:
2715:
2700:
1960:10.1146/annurev.immunol.16.1.111
676:external side of plasma membrane
576:
338:
331:
325:
302:
237:
230:
224:
199:
40:
6450:Interferon omega (IFN-ω, IFNW1)
2191:10.1179/1743132813Y.0000000190
1410:production, and expression of
1394:by CD40L (e.g. from activated
1210:, an important process in the
1196:immunoglobulin class switching
651:integral component of membrane
587:More reference expression data
556:More reference expression data
1:
2548:Journal of Biomedical Science
2482:Subauste CS (February 2002).
752:regulation of immune response
323:
222:
29:Protein-coding gene in humans
2338:Journal of Leukocyte Biology
1613:10.4049/jimmunol.149.12.3817
707:leukocyte cell-cell adhesion
6984:Clusters of differentiation
6979:Genes on human chromosome X
6294:Thrombopoietin (THPO, MGDF)
6060:Pegol sihematide (EPO-018B)
5980:Carbamylated erythropoietin
2771:clusters of differentiation
2593:10.1007/978-0-387-89520-8_2
2240:10.4049/jimmunol.181.3.1622
2052:10.4049/jimmunol.155.7.3329
1948:Annual Review of Immunology
1650:10.4049/jimmunol.152.5.2163
1158:of molecules. It binds to
7000:
2647:gene details page in the
2531:10.1089/152581602760404595
2007:10.1038/s41598-019-54976-4
1327:to a specialized group of
472:mucosa of transverse colon
6843:Tofacitinib (tasocitinib)
6800:Tofacitinib (tasocitinib)
6707:Tofacitinib (tasocitinib)
5758:Colony-stimulating factor
2695:
2387:10.3109/10428190009058499
2317:10.3109/10428199609067572
1528:"Mouse PubMed Reference:"
1510:"Human PubMed Reference:"
1253:Specific effects on cells
1180:T follicular helper cells
1122:
1117:
1113:
1106:
1090:
1077:Chr X: 136.65 – 136.66 Mb
1071:
1056:
1035:
1024:
1009:
988:
977:
964:
960:
945:
941:
932:
919:
915:
900:
896:
887:
874:
870:
855:
851:
842:
827:
820:
816:
800:
605:
601:
584:
575:
566:
553:
502:
493:
440:
431:
401:
393:
389:
372:
359:
322:
301:
292:
288:
271:
258:
221:
198:
189:
185:
140:
137:
127:
120:
115:
84:
79:
62:
57:
52:
48:
39:
34:
6521:Interferon gamma (IFN-γ)
5793:proinflammatory cytokine
2630:Medical Subject Headings
1442:CD154 has been shown to
1237:Dartmouth Medical School
1164:antigen-presenting cells
522:bones of pectoral girdle
6421:Interferon beta (IFN-β)
2375:Leukemia & Lymphoma
2305:Leukemia & Lymphoma
1820:10.1073/pnas.89.14.6550
1402:production, as well as
1400:reactive oxygen species
1198:and is associated with
1154:and is a member of the
1084:Chr X: 56.26 – 56.27 Mb
6899:Cardiotrophin 1 (CT-1)
4924:/PARC/DCCK1/AMAC1/MIP4
1711:10.1084/jem.175.4.1091
1563:10.1084/jem.175.4.1091
1317:
1212:adaptive immune system
1190:cells, CD154 promotes
757:B cell differentiation
6896:Additional cytokines:
6823:Decernotinib (VX-509)
6460:Peginterferon alfa-2b
6455:Peginterferon alfa-2a
5975:Asialo erythropoietin
2228:Journal of Immunology
2179:Neurological Research
2040:Journal of Immunology
1638:Journal of Immunology
1600:Journal of Immunology
1311:
762:inflammatory response
625:CD40 receptor binding
6411:Interferon alfacon-1
6040:Erythropoietin (EPO)
2641:genome location and
2494:(Suppl 1): S83–S89.
2412:Immunologic Research
767:T cell costimulation
737:B cell proliferation
671:extracellular region
356:X A6|X 31.21 cM
317:X chromosome (mouse)
215:X chromosome (human)
80:List of PDB id codes
53:Available structures
6558:See IL-28R (IFNLR)
6526:Interferon gamma 1b
6416:Interferon alpha-n3
5489:Interferon type III
2649:UCSC Genome Browser
2424:10.1385/IR:24:3:311
2095:1995Natur.378..617G
1999:2019NatSR...918577S
1811:1992PNAS...89.6550N
1756:1992Natur.357...80A
1364:affinity maturation
1228:Columbia University
1208:affinity maturation
727:platelet activation
691:extracellular space
480:epithelium of colon
6914:Oncostatin M (OSM)
6440:Interferon beta 1b
6435:Interferon beta 1a
6406:Interferon alfa n1
6401:Interferon alfa 2b
6396:Interferon alfa 2a
6230:Kinase inhibitors:
2350:10.1002/jlb.67.1.2
1987:Scientific Reports
1906:10.1007/PL00000776
1853:"Patent 5,474,771"
1412:adhesion molecules
1339:. If an activated
1318:
1200:hyper IgM syndrome
922:ENSMUSG00000031132
700:Biological process
644:Cellular component
613:Molecular function
510:Meckel's cartilage
179:CD40LG - orthologs
6966:
6965:
6962:
6961:
6884:
6883:
6651:
6569:
6568:
6302:
6301:
6045:Erythropoietin-Fc
5919:Cytokine receptor
5885:
5884:
5778:
5777:
5736:
5735:
5633:
5632:
5629:
5628:
5437:
5436:
5115:
5114:
4770:
4769:
2733:
2732:
2602:978-0-387-89519-2
2560:10.1159/000077892
2457:10.1159/000060547
2280:The Immune System
2276:Parham P (2004).
2144:(16): 1917–1923.
2089:(6557): 617–620.
1805:(14): 6550–6554.
1606:(12): 3817–3826.
1392:endothelial cells
1386:Endothelial cells
1360:isotype switching
1133:
1132:
1129:
1128:
1102:
1101:
1067:
1066:
1046:
1045:
1020:
1019:
999:
998:
973:
972:
954:
953:
928:
927:
909:
908:
883:
882:
864:
863:
812:
811:
742:isotype switching
620:cytokine activity
597:
596:
593:
592:
562:
561:
549:
548:
487:
486:
385:
384:
284:
283:
111:
110:
107:
106:
63:Ortholog search:
16:(Redirected from
6991:
6655:
6645:
6638:
6497:Decoy receptors:
6313:
5990:Darbepoetin alfa
5955:
5912:
5905:
5898:
5889:
5516:
5448:
5231:
5216:
4828:
4819:
4797:
4790:
4783:
4774:
2760:
2753:
2746:
2737:
2719:
2704:
2684:
2677:
2670:
2661:
2614:
2579:
2542:
2513:
2503:
2478:
2443:
2406:
2381:(5–6): 461–472.
2369:
2328:
2299:
2283:
2262:
2261:
2251:
2234:(3): 1622–1626.
2219:
2213:
2212:
2202:
2170:
2164:
2163:
2153:
2129:
2123:
2122:
2103:10.1038/378617a0
2078:
2072:
2071:
2046:(7): 3329–3337.
2035:
2029:
2028:
2018:
1978:
1972:
1971:
1943:
1937:
1936:
1918:
1908:
1884:
1878:
1877:
1875:
1874:
1868:
1857:
1849:
1843:
1842:
1832:
1822:
1790:
1784:
1783:
1764:10.1038/357080a0
1739:
1733:
1732:
1722:
1705:(4): 1091–1101.
1690:
1684:
1683:
1676:
1670:
1669:
1644:(5): 2163–2171.
1632:
1626:
1625:
1615:
1591:
1585:
1584:
1574:
1557:(4): 1091–1101.
1542:
1536:
1535:
1524:
1518:
1517:
1506:
1500:
1490:
1479:
1469:
1204:germinal centers
1115:
1114:
1086:
1079:
1062:
1050:
1041:
1029:
1025:RefSeq (protein)
1015:
1003:
994:
982:
958:
939:
913:
894:
868:
849:
818:
603:
589:
580:
573:
558:
498:
496:Top expressed in
491:
436:
434:Top expressed in
429:
408:
391:
381:
368:
357:
342:
335:
329:
318:
306:
290:
280:
267:
256:
241:
234:
228:
217:
203:
187:
181:
132:
125:
102:
77:
71:
50:
49:
44:
32:
21:
6999:
6998:
6994:
6993:
6992:
6990:
6989:
6988:
6969:
6968:
6967:
6958:
6880:
6876:Deucravacitinib
6862:
6804:
6716:
6644:
6629:
6609:
6589:
6565:
6545:
6504:
6338:Interferon alfa
6298:
6257:
6237:
6186:
6120:
6116:Pegnartograstim
6101:Lipegfilgrastim
6064:
6010:Epoetin epsilon
5944:
5924:
5916:
5886:
5881:
5847:
5826:
5784:
5774:
5732:
5705:
5625:
5607:
5505:
5433:
5402:
5365:
5303:
5275:
5226:
5224:
5222:
5205:
5111:
5090:
5074:
4977:
4810:
4801:
4771:
4766:
4570:
4364:
4113:
3797:
3520:
3180:
2778:
2764:
2734:
2729:
2726:
2720:
2711:
2705:
2691:
2688:
2622:
2617:
2603:
2582:
2545:
2516:
2481:
2467:
2446:
2409:
2372:
2331:
2302:
2296:
2275:
2271:
2269:Further reading
2266:
2265:
2221:
2220:
2216:
2172:
2171:
2167:
2131:
2130:
2126:
2080:
2079:
2075:
2037:
2036:
2032:
1980:
1979:
1975:
1945:
1944:
1940:
1886:
1885:
1881:
1872:
1870:
1866:
1855:
1851:
1850:
1846:
1792:
1791:
1787:
1750:(6373): 80–82.
1741:
1740:
1736:
1692:
1691:
1687:
1678:
1677:
1673:
1634:
1633:
1629:
1593:
1592:
1588:
1544:
1543:
1539:
1526:
1525:
1521:
1508:
1507:
1503:
1491:
1482:
1470:
1461:
1456:
1440:
1388:
1380:germinal centre
1376:class switching
1353:germinal center
1344:
1336:
1306:
1267:
1255:
1246:
1220:
1189:
1185:
1172:integrin αIIbβ3
1156:TNF superfamily
1124:View/Edit Mouse
1119:View/Edit Human
1082:
1075:
1072:Location (UCSC)
1058:
1037:
1011:
990:
903:ENSG00000102245
796:
747:immune response
695:
661:plasma membrane
639:
635:protein binding
585:
554:
545:
540:
536:
532:
528:
524:
520:
516:
512:
508:
494:
483:
478:
474:
470:
466:
462:
458:
454:
450:
446:
432:
376:
363:
355:
345:
344:
343:
336:
316:
293:Gene location (
275:
262:
254:
244:
243:
242:
235:
213:
190:Gene location (
141:
128:
121:
86:
64:
30:
23:
22:
15:
12:
11:
5:
6997:
6995:
6987:
6986:
6981:
6971:
6970:
6964:
6963:
6960:
6959:
6957:
6956:
6951:
6946:
6941:
6936:
6931:
6922:
6921:
6916:
6911:
6906:
6901:
6892:
6890:
6886:
6885:
6882:
6881:
6879:
6878:
6872:
6870:
6864:
6863:
6861:
6860:
6855:
6850:
6845:
6840:
6835:
6830:
6825:
6820:
6818:Cercosporamide
6814:
6812:
6806:
6805:
6803:
6802:
6797:
6792:
6787:
6782:
6777:
6772:
6767:
6762:
6760:Deuruxolitinib
6757:
6752:
6747:
6742:
6737:
6732:
6726:
6724:
6718:
6717:
6715:
6714:
6709:
6704:
6699:
6694:
6689:
6684:
6679:
6677:Deuruxolitinib
6674:
6669:
6663:
6661:
6652:
6635:
6631:
6630:
6628:
6627:
6619:
6617:
6611:
6610:
6608:
6607:
6599:
6597:
6591:
6590:
6588:
6587:
6579:
6577:
6571:
6570:
6567:
6566:
6564:
6563:
6555:
6553:
6551:IFNLR (λ, III)
6547:
6546:
6544:
6543:
6538:
6529:
6528:
6523:
6514:
6512:
6506:
6505:
6503:
6502:
6493:
6492:
6487:
6482:
6477:
6472:
6463:
6462:
6457:
6452:
6447:
6442:
6437:
6432:
6418:
6413:
6408:
6403:
6398:
6393:
6335:
6330:
6321:
6319:
6317:IFNAR (α/β, I)
6310:
6304:
6303:
6300:
6299:
6297:
6296:
6291:
6286:
6284:Promegapoietin
6281:
6276:
6267:
6265:
6263:Thrombopoietin
6259:
6258:
6256:
6255:
6247:
6245:
6239:
6238:
6236:
6235:
6226:
6225:
6220:
6215:
6210:
6208:Interleukin-34
6205:
6196:
6194:
6188:
6187:
6185:
6184:
6179:
6174:
6165:
6164:
6159:
6154:
6149:
6144:
6139:
6130:
6128:
6122:
6121:
6119:
6118:
6113:
6108:
6103:
6098:
6093:
6088:
6083:
6074:
6072:
6066:
6065:
6063:
6062:
6057:
6052:
6047:
6042:
6037:
6032:
6027:
6022:
6017:
6012:
6007:
6002:
5997:
5992:
5987:
5982:
5977:
5972:
5963:
5961:
5959:Erythropoietin
5952:
5946:
5945:
5943:
5942:
5934:
5932:
5926:
5925:
5917:
5915:
5914:
5907:
5900:
5892:
5883:
5882:
5880:
5879:
5878:
5877:
5876:
5875:
5870:
5865:
5860:
5855:
5845:
5841:
5840:
5839:
5834:
5824:
5815:
5809:
5808:
5807:
5806:
5801:
5788:
5786:
5780:
5779:
5776:
5775:
5773:
5772:
5767:
5762:
5761:
5760:
5755:
5744:
5742:
5738:
5737:
5734:
5733:
5731:
5730:
5715:
5713:
5707:
5706:
5704:
5703:
5698:
5693:
5688:
5683:
5678:
5673:
5668:
5663:
5658:
5653:
5643:
5641:
5639:Ig superfamily
5635:
5634:
5631:
5630:
5627:
5626:
5624:
5623:
5617:
5615:
5609:
5608:
5606:
5605:
5600:
5595:
5590:
5585:
5580:
5575:
5570:
5565:
5560:
5555:
5550:
5545:
5540:
5535:
5530:
5524:
5522:
5513:
5507:
5506:
5504:
5503:
5502:
5501:
5496:
5486:
5481:
5476:
5471:
5466:
5456:
5454:
5445:
5439:
5438:
5435:
5434:
5432:
5431:
5426:
5421:
5416:
5410:
5408:
5404:
5403:
5401:
5400:
5395:
5390:
5385:
5379:
5377:
5367:
5366:
5364:
5363:
5362:
5361:
5356:
5351:
5346:
5335:
5330:
5325:
5320:
5314:
5312:
5305:
5304:
5302:
5301:
5296:
5291:
5285:
5283:
5277:
5276:
5274:
5273:
5268:
5263:
5258:
5249:
5239:
5237:
5228:
5213:
5207:
5206:
5204:
5203:
5198:
5193:
5188:
5183:
5178:
5173:
5168:
5163:
5158:
5153:
5148:
5147:
5146:
5141:
5131:
5125:
5123:
5117:
5116:
5113:
5112:
5110:
5109:
5104:
5098:
5096:
5092:
5091:
5089:
5088:
5082:
5080:
5076:
5075:
5073:
5072:
5067:
5062:
5057:
5052:
5047:
5042:
5037:
5032:
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4992:
4985:
4983:
4979:
4978:
4976:
4975:
4970:
4965:
4960:
4955:
4950:
4945:
4940:
4935:
4930:
4925:
4919:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4874:
4869:
4864:
4858:
4852:
4846:
4840:
4834:
4832:
4825:
4816:
4812:
4811:
4804:Cell signaling
4802:
4800:
4799:
4792:
4785:
4777:
4768:
4767:
4765:
4764:
4759:
4754:
4749:
4744:
4739:
4734:
4729:
4724:
4719:
4714:
4709:
4704:
4699:
4694:
4689:
4684:
4679:
4674:
4669:
4664:
4659:
4654:
4649:
4644:
4639:
4634:
4629:
4624:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4584:
4578:
4576:
4572:
4571:
4569:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4513:
4508:
4503:
4498:
4493:
4488:
4483:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4372:
4370:
4366:
4365:
4363:
4362:
4357:
4348:
4343:
4338:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4302:
4301:
4296:
4286:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4241:
4236:
4231:
4226:
4221:
4215:
4206:
4201:
4200:
4199:
4194:
4184:
4179:
4178:
4177:
4172:
4162:
4157:
4152:
4147:
4142:
4137:
4132:
4127:
4121:
4119:
4115:
4114:
4112:
4111:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4071:
4066:
4061:
4056:
4051:
4046:
4041:
4036:
4031:
4026:
4025:
4024:
4019:
4009:
4004:
3999:
3994:
3993:
3992:
3987:
3982:
3972:
3967:
3962:
3957:
3952:
3951:
3950:
3945:
3935:
3930:
3925:
3920:
3915:
3910:
3905:
3904:
3903:
3898:
3888:
3882:
3877:
3872:
3867:
3858:
3853:
3852:
3851:
3846:
3841:
3831:
3826:
3821:
3816:
3811:
3805:
3803:
3799:
3798:
3796:
3795:
3790:
3785:
3780:
3775:
3770:
3765:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3669:
3668:
3663:
3653:
3652:
3651:
3646:
3636:
3631:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3586:
3581:
3576:
3575:
3574:
3569:
3559:
3554:
3549:
3544:
3539:
3534:
3528:
3526:
3522:
3521:
3519:
3518:
3513:
3508:
3503:
3498:
3493:
3488:
3483:
3478:
3469:
3464:
3459:
3454:
3449:
3444:
3443:
3442:
3437:
3432:
3427:
3422:
3417:
3407:
3402:
3397:
3392:
3387:
3382:
3381:
3380:
3375:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3324:
3323:
3318:
3313:
3308:
3303:
3298:
3288:
3287:
3286:
3281:
3276:
3266:
3261:
3260:
3259:
3254:
3249:
3239:
3234:
3229:
3224:
3219:
3214:
3209:
3204:
3199:
3194:
3188:
3186:
3182:
3181:
3179:
3178:
3173:
3172:
3171:
3166:
3161:
3156:
3151:
3146:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3105:
3104:
3099:
3094:
3089:
3079:
3074:
3069:
3064:
3059:
3054:
3049:
3044:
3039:
3034:
3033:
3032:
3027:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2977:
2972:
2967:
2962:
2957:
2952:
2947:
2946:
2945:
2940:
2930:
2925:
2920:
2915:
2914:
2913:
2908:
2903:
2898:
2888:
2883:
2878:
2877:
2876:
2866:
2861:
2856:
2851:
2846:
2845:
2844:
2839:
2834:
2824:
2819:
2818:
2817:
2812:
2807:
2802:
2797:
2786:
2784:
2780:
2779:
2765:
2763:
2762:
2755:
2748:
2740:
2731:
2730:
2728:
2727:
2721:
2714:
2712:
2706:
2699:
2696:
2693:
2692:
2689:
2687:
2686:
2679:
2672:
2664:
2658:
2657:
2652:
2633:
2621:
2620:External links
2618:
2616:
2615:
2601:
2580:
2554:(4): 426–438.
2543:
2525:(5): 787–801.
2514:
2501:10.1086/338003
2479:
2465:
2444:
2418:(3): 311–324.
2407:
2370:
2332:van Kooten C,
2329:
2300:
2294:
2272:
2270:
2267:
2264:
2263:
2214:
2185:(7): 693–700.
2165:
2124:
2073:
2030:
1973:
1938:
1879:
1844:
1785:
1734:
1685:
1671:
1627:
1586:
1537:
1519:
1501:
1480:
1458:
1457:
1455:
1452:
1439:
1436:
1390:Activation of
1387:
1384:
1372:memory B cells
1342:
1334:
1329:helper T cells
1305:
1302:
1277:from Th1 type
1266:
1263:
1254:
1251:
1245:
1242:
1219:
1216:
1187:
1183:
1138:, also called
1131:
1130:
1127:
1126:
1121:
1111:
1110:
1104:
1103:
1100:
1099:
1097:
1095:
1088:
1087:
1080:
1073:
1069:
1068:
1065:
1064:
1054:
1053:
1047:
1044:
1043:
1033:
1032:
1026:
1022:
1021:
1018:
1017:
1007:
1006:
1000:
997:
996:
986:
985:
979:
975:
974:
971:
970:
962:
961:
955:
952:
951:
943:
942:
936:
930:
929:
926:
925:
917:
916:
910:
907:
906:
898:
897:
891:
885:
884:
881:
880:
872:
871:
865:
862:
861:
853:
852:
846:
840:
839:
834:
829:
825:
824:
814:
813:
810:
809:
798:
797:
795:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
703:
701:
697:
696:
694:
693:
688:
683:
678:
673:
668:
663:
658:
653:
647:
645:
641:
640:
638:
637:
632:
627:
622:
616:
614:
610:
609:
599:
598:
595:
594:
591:
590:
582:
581:
570:
564:
563:
560:
559:
551:
550:
547:
546:
544:
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
500:
499:
488:
485:
484:
482:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
438:
437:
425:
424:
416:
405:
399:
398:
395:RNA expression
387:
386:
383:
382:
374:
370:
369:
361:
358:
353:
347:
346:
337:
330:
324:
320:
319:
314:
308:
307:
299:
298:
286:
285:
282:
281:
273:
269:
268:
260:
257:
252:
246:
245:
236:
229:
223:
219:
218:
211:
205:
204:
196:
195:
183:
182:
139:
135:
134:
126:
118:
117:
113:
112:
109:
108:
105:
104:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6996:
6985:
6982:
6980:
6977:
6976:
6974:
6955:
6952:
6950:
6947:
6945:
6942:
6940:
6937:
6935:
6932:
6930:
6927:
6924:
6923:
6920:
6917:
6915:
6912:
6910:
6907:
6905:
6902:
6900:
6897:
6894:
6893:
6891:
6887:
6877:
6874:
6873:
6871:
6869:
6865:
6859:
6856:
6854:
6851:
6849:
6846:
6844:
6841:
6839:
6836:
6834:
6831:
6829:
6826:
6824:
6821:
6819:
6816:
6815:
6813:
6811:
6807:
6801:
6798:
6796:
6793:
6791:
6788:
6786:
6783:
6781:
6778:
6776:
6773:
6771:
6768:
6766:
6763:
6761:
6758:
6756:
6753:
6751:
6748:
6746:
6743:
6741:
6738:
6736:
6733:
6731:
6728:
6727:
6725:
6723:
6719:
6713:
6710:
6708:
6705:
6703:
6700:
6698:
6695:
6693:
6690:
6688:
6685:
6683:
6680:
6678:
6675:
6673:
6670:
6668:
6665:
6664:
6662:
6660:
6656:
6653:
6649:
6643:
6639:
6636:
6632:
6625:
6621:
6620:
6618:
6616:
6612:
6605:
6601:
6600:
6598:
6596:
6592:
6585:
6581:
6580:
6578:
6576:
6572:
6561:
6557:
6556:
6554:
6552:
6548:
6542:
6539:
6537:
6534:
6531:
6530:
6527:
6524:
6522:
6519:
6516:
6515:
6513:
6511:
6510:IFNGR (γ, II)
6507:
6501:
6498:
6495:
6494:
6491:
6488:
6486:
6483:
6481:
6478:
6476:
6473:
6471:
6468:
6465:
6464:
6461:
6458:
6456:
6453:
6451:
6448:
6446:
6443:
6441:
6438:
6436:
6433:
6430:
6426:
6422:
6419:
6417:
6414:
6412:
6409:
6407:
6404:
6402:
6399:
6397:
6394:
6391:
6387:
6383:
6379:
6375:
6371:
6367:
6363:
6359:
6355:
6351:
6347:
6343:
6339:
6336:
6334:
6331:
6329:
6328:Albinterferon
6326:
6323:
6322:
6320:
6318:
6314:
6311:
6309:
6305:
6295:
6292:
6290:
6287:
6285:
6282:
6280:
6277:
6275:
6272:
6269:
6268:
6266:
6264:
6260:
6253:
6249:
6248:
6246:
6244:
6240:
6234:
6231:
6228:
6227:
6224:
6221:
6219:
6216:
6214:
6211:
6209:
6206:
6204:
6201:
6198:
6197:
6195:
6193:
6189:
6183:
6180:
6178:
6175:
6173:
6170:
6167:
6166:
6163:
6160:
6158:
6155:
6153:
6150:
6148:
6145:
6143:
6140:
6138:
6135:
6132:
6131:
6129:
6127:
6126:GM-CSF (CSF2)
6123:
6117:
6114:
6112:
6111:Pegfilgrastim
6109:
6107:
6104:
6102:
6099:
6097:
6094:
6092:
6089:
6087:
6084:
6082:
6079:
6076:
6075:
6073:
6071:
6067:
6061:
6058:
6056:
6053:
6051:
6048:
6046:
6043:
6041:
6038:
6036:
6033:
6031:
6030:Epoetin theta
6028:
6026:
6025:Epoetin omega
6023:
6021:
6020:Epoetin kappa
6018:
6016:
6015:Epoetin gamma
6013:
6011:
6008:
6006:
6005:Epoetin delta
6003:
6001:
5998:
5996:
5993:
5991:
5988:
5986:
5983:
5981:
5978:
5976:
5973:
5971:
5968:
5965:
5964:
5962:
5960:
5956:
5953:
5951:
5947:
5940:
5936:
5935:
5933:
5931:
5927:
5923:
5920:
5913:
5908:
5906:
5901:
5899:
5894:
5893:
5890:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5850:
5849:
5842:
5838:
5835:
5833:
5830:
5829:
5828:
5821:
5820:
5819:
5816:
5814:
5811:
5810:
5805:
5802:
5800:
5797:
5796:
5795:
5794:
5790:
5789:
5787:
5781:
5771:
5768:
5766:
5763:
5759:
5756:
5754:
5751:
5750:
5749:
5748:Hematopoietic
5746:
5745:
5743:
5739:
5728:
5724:
5720:
5717:
5716:
5714:
5712:
5708:
5702:
5699:
5697:
5694:
5692:
5689:
5687:
5684:
5682:
5679:
5677:
5674:
5672:
5669:
5667:
5664:
5662:
5659:
5657:
5654:
5652:
5648:
5645:
5644:
5642:
5640:
5636:
5622:
5619:
5618:
5616:
5614:
5610:
5604:
5601:
5599:
5596:
5594:
5591:
5589:
5586:
5584:
5581:
5579:
5576:
5574:
5571:
5569:
5566:
5564:
5561:
5559:
5556:
5554:
5551:
5549:
5546:
5544:
5541:
5539:
5536:
5534:
5531:
5529:
5526:
5525:
5523:
5521:
5517:
5514:
5512:
5508:
5500:
5497:
5495:
5492:
5491:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5461:
5458:
5457:
5455:
5453:
5449:
5446:
5444:
5440:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5411:
5409:
5405:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5380:
5378:
5376:
5372:
5368:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5341:
5340:
5339:
5336:
5334:
5331:
5329:
5326:
5324:
5321:
5319:
5316:
5315:
5313:
5311:
5306:
5300:
5297:
5295:
5292:
5290:
5287:
5286:
5284:
5282:
5278:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5253:
5250:
5248:
5244:
5241:
5240:
5238:
5236:
5232:
5229:
5221:
5217:
5214:
5212:
5208:
5202:
5199:
5197:
5194:
5192:
5189:
5187:
5184:
5182:
5179:
5177:
5174:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5156:TNFSF5/CD40LG
5154:
5152:
5149:
5145:
5142:
5140:
5137:
5136:
5135:
5132:
5130:
5127:
5126:
5124:
5122:
5118:
5108:
5105:
5103:
5100:
5099:
5097:
5093:
5087:
5084:
5083:
5081:
5077:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4990:
4987:
4986:
4984:
4980:
4974:
4971:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4944:
4941:
4939:
4936:
4934:
4931:
4929:
4926:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4900:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4873:
4870:
4868:
4865:
4862:
4859:
4856:
4853:
4850:
4847:
4844:
4841:
4839:
4836:
4835:
4833:
4829:
4826:
4824:
4820:
4817:
4813:
4809:
4805:
4798:
4793:
4791:
4786:
4784:
4779:
4778:
4775:
4763:
4760:
4758:
4755:
4753:
4750:
4748:
4745:
4743:
4740:
4738:
4735:
4733:
4730:
4728:
4725:
4723:
4720:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4700:
4698:
4695:
4693:
4690:
4688:
4685:
4683:
4680:
4678:
4675:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4579:
4577:
4573:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4497:
4494:
4492:
4489:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
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2646:
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2631:
2627:
2626:CD154+Antigen
2624:
2623:
2619:
2612:
2608:
2604:
2598:
2594:
2590:
2586:
2581:
2577:
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2466:3-8055-7308-1
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2295:0-8153-4093-1
2291:
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2017:
2012:
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1880:
1869:on 2016-03-04
1865:
1861:
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1468:
1466:
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1460:
1453:
1451:
1449:
1445:
1437:
1435:
1433:
1432:atherogenesis
1429:
1425:
1421:
1417:
1413:
1409:
1405:
1401:
1397:
1393:
1385:
1383:
1381:
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1369:
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1272:
1264:
1262:
1260:
1252:
1250:
1243:
1241:
1238:
1234:
1229:
1225:
1224:Seth Lederman
1217:
1215:
1213:
1209:
1205:
1201:
1197:
1193:
1181:
1177:
1173:
1170:integrin and
1169:
1165:
1161:
1157:
1153:
1149:
1145:
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1137:
1125:
1120:
1116:
1112:
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1061:
1055:
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1042:
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1034:
1030:
1027:
1023:
1016:
1014:
1008:
1004:
1001:
995:
993:
987:
983:
980:
978:RefSeq (mRNA)
976:
969:
968:
963:
959:
956:
950:
949:
944:
940:
937:
935:
931:
924:
923:
918:
914:
911:
905:
904:
899:
895:
892:
890:
886:
879:
878:
873:
869:
866:
860:
859:
854:
850:
847:
845:
841:
838:
835:
833:
830:
826:
823:
819:
815:
808:
804:
799:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
704:
702:
699:
698:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
648:
646:
643:
642:
636:
633:
631:
628:
626:
623:
621:
618:
617:
615:
612:
611:
608:
607:Gene ontology
604:
600:
588:
583:
579:
574:
571:
569:
565:
557:
552:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
504:
501:
497:
492:
489:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
442:
439:
435:
430:
427:
426:
423:
421:
417:
415:
414:
410:
409:
406:
404:
400:
396:
392:
388:
380:
375:
371:
367:
362:
352:
348:
341:
334:
328:
321:
313:
309:
305:
300:
296:
291:
287:
279:
274:
270:
266:
261:
251:
247:
240:
233:
227:
220:
216:
210:
206:
202:
197:
193:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
136:
131:
124:
119:
114:
103:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
6934:Lestaurtinib
6925:
6895:
6833:Ritlecitinib
6765:Lestaurtinib
6712:Upadacitinib
6541:Fontolizumab
6532:
6517:
6496:
6485:Rontalizumab
6466:
6324:
6279:Pegacaristim
6270:
6229:
6199:
6192:M-CSF (CSF1)
6172:Mavrilimumab
6168:
6162:Sargramostim
6152:Molgramostim
6137:Ecogramostim
6133:
6106:Nartograstim
6077:
6070:G-CSF (CSF3)
6055:Peginesatide
6035:Epoetin zeta
6000:Epoetin beta
5995:Epoetin alfa
5966:
5843:
5822:
5791:
5783:By function/
5494:IL28/IFNL2+3
5155:
4288:
4208:
4186:
4164:
4011:
3974:
3937:
3890:
3860:
3833:
3823:
3655:
3561:
3409:
3138:
2890:
2722:
2707:
2643:
2637:
2584:
2551:
2547:
2522:
2518:
2491:
2487:
2448:
2415:
2411:
2378:
2374:
2341:
2337:
2334:Banchereau J
2311:(1–2): 1–8.
2308:
2304:
2279:
2231:
2227:
2217:
2182:
2178:
2168:
2141:
2137:
2127:
2086:
2082:
2076:
2043:
2039:
2033:
1993:(1): 18577.
1990:
1986:
1976:
1951:
1947:
1941:
1896:
1892:
1882:
1871:. Retrieved
1864:the original
1859:
1847:
1802:
1798:
1788:
1747:
1743:
1737:
1702:
1698:
1688:
1674:
1641:
1637:
1630:
1603:
1599:
1589:
1554:
1550:
1540:
1531:
1522:
1513:
1504:
1441:
1438:Interactions
1389:
1368:plasma cells
1323:can present
1319:
1298:phagocytosed
1268:
1256:
1247:
1221:
1186:cells). On T
1143:
1139:
1135:
1134:
1057:
1036:
1010:
989:
965:
946:
920:
901:
875:
856:
836:
831:
686:cell surface
534:right kidney
418:
411:
276:136,660,390
263:136,648,158
138:External IDs
85:
26:
6944:Quizartinib
6939:Midostaurin
6828:Peficitinib
6790:Ruxolitinib
6785:Peficitinib
6740:Baricitinib
6702:Ruxolitinib
6697:Peficitinib
6692:Oclacitinib
6687:Momelotinib
6672:Baricitinib
6667:Abrocitinib
6575:Interleukin
6533:Antibodies:
6490:Sifalimumab
6475:Faralimomab
6470:Anifrolumab
6467:Antibodies:
6289:Romiplostim
6274:Eltrombopag
6243:SCF (c-Kit)
6169:Antibodies:
6157:Regramostim
6091:Lenograstim
5711:IL17 family
5452:IL10 family
5371:IL12 family
5223:(grouped by
5211:Interleukin
5134:Lymphotoxin
2690:PDB gallery
2344:(1): 2–17.
2138:Circulation
1954:: 111–135.
1899:(1): 4–43.
1398:) leads to
1265:Macrophages
1140:CD40 ligand
476:bone marrow
468:gallbladder
444:granulocyte
377:56,269,402
364:56,257,503
116:Identifiers
6973:Categories
6929:Emfilermin
6780:Pacritinib
6682:Filgotinib
6648:inhibitors
6536:Emapalumab
6308:Interferon
6233:Agerafenib
6223:Mirimostim
6213:Lanimostim
6147:Milodistim
6096:Leridistim
6081:Filgrastim
5922:modulators
5818:Lymphokine
5656:IL1B/IL1F2
5651:IL1A/IL1F1
5647:IL1 family
5511:Interferon
5499:IL29/IFNL1
2773:(see also
1873:2016-06-18
1499:, May 2017
1478:, May 2017
1454:References
1428:leukocytes
1416:E-selectin
1290:macrophage
1271:macrophage
1244:Expression
448:lymph node
422:(ortholog)
159:HomoloGene
6954:Sunitinib
6949:Sorafenib
6858:ZM-449829
6848:WHI-P 154
6838:TCS-21311
6775:NSC-33994
6730:Atiprimod
6518:Agonists:
6500:Bifarcept
6325:Agonists:
6271:Agonists:
6203:Cilmostim
6200:Agonists:
6177:Namilumab
6134:Agonists:
6078:Agonists:
5967:Agonists:
5930:Chemokine
5696:33/IL1F11
5661:1Ra/IL1F3
5308:IL6 like/
5025:CXCL8/IL8
4823:Chemokine
4815:By family
4808:cytokines
2576:202658036
1404:chemokine
1396:platelets
1060:NP_035746
1039:NP_000065
1013:NM_011616
992:NM_000074
822:Orthologs
167:GeneCards
6853:ZM-39923
6770:NSC-7908
6735:AZD-1480
6626:instead.
6606:instead.
6586:instead.
6562:instead.
6480:MEDI-545
6254:instead.
6182:Otilimab
5985:CNTO-530
5941:instead.
5813:Monokine
5342:+non IL
5227:subunit)
5225:receptor
5196:TNFSF13B
5144:TNFC/LTB
5139:TNFB/LTA
2767:Proteins
2611:19760064
2568:15153777
2539:12427285
2510:11865444
2475:11826760
2440:19537892
2432:11817328
2403:39398949
2395:11042507
2366:35592719
2358:10647992
2258:18641297
2209:23561892
2160:14568885
2068:39514335
2025:31819097
1933:33085593
1925:11229815
1916:11146501
1666:42460521
1495:–
1474:–
1444:interact
1414:such as
1408:cytokine
1357:antibody
1325:antigens
1108:Wikidata
801:Sources:
656:membrane
526:shoulder
456:appendix
6795:SD-1008
5970:ARA-290
5701:18/IL1G
5443:Type II
5375:IL12RB1
5281:β chain
5235:γ chain
5191:TNFSF13
5186:TNFSF11
5181:TNFSF10
4863:/RANTES
4575:301–350
4369:251–300
4321:CD240CE
4118:201–250
3802:151–200
3525:101–150
2325:8907262
2286:169–173
2249:2853377
2200:3770830
2119:4259617
2111:8524395
2091:Bibcode
2060:7561026
2016:6901466
1995:Bibcode
1968:9597126
1839:1378631
1807:Bibcode
1780:4336943
1772:1374165
1752:Bibcode
1729:1348081
1720:2119166
1658:7907632
1622:1281189
1581:1348081
1572:2119166
1497:Ensembl
1476:Ensembl
1331:called
1321:B cells
1304:B cells
1288:on the
1282:T cells
1269:In the
1233:Immunex
1218:History
1178:called
1176:T cells
1152:T cells
1148:protein
1146:, is a
934:UniProt
889:Ensembl
828:Species
807:QuickGO
542:jejunum
538:scapula
530:humerus
397:pattern
123:Aliases
6889:Others
6755:CYT387
6745:CHZ868
6634:Others
6390:IFNA21
6386:IFNA17
6382:IFNA16
6378:IFNA14
6374:IFNA13
6370:IFNA10
5691:IL1F10
5588:IFNA21
5583:IFNA17
5578:IFNA16
5573:IFNA14
5568:IFNA13
5563:IFNA10
5220:Type I
5176:TNFSF9
5171:TNFSF8
5166:TNFSF7
5161:TNFSF6
5151:TNFSF4
5086:CX3CL1
5070:CXCL17
5065:CXCL16
5060:CXCL15
5055:CXCL14
5050:CXCL13
5045:CXCL12
5040:CXCL11
5035:CXCL10
4857:/MIP1β
4851:/MIP1α
4582:CD300A
4541:CDw293
4326:CD240D
4187:CD213a
4165:CDw210
4130:CD202b
4104:CDw199
4099:CDw198
3753:CD140b
3185:51–100
2644:CD40LG
2638:CD40LG
2635:Human
2632:(MeSH)
2609:
2599:
2574:
2566:
2537:
2508:
2473:
2463:
2438:
2430:
2401:
2393:
2364:
2356:
2323:
2292:
2256:
2246:
2207:
2197:
2158:
2117:
2109:
2083:Nature
2066:
2058:
2023:
2013:
1966:
1931:
1923:
1913:
1837:
1827:
1778:
1770:
1744:Nature
1727:
1717:
1664:
1656:
1620:
1579:
1569:
1448:RNF128
1424:VCAM-1
1422:, and
1420:ICAM-1
1355:where
1314:B cell
1259:T cell
1192:B cell
1094:search
1092:PubMed
967:P27548
948:P29965
844:Entrez
568:BioGPS
514:spleen
506:thymus
464:spleen
460:rectum
255:Xq26.3
171:CD40LG
147:300386
130:CD40LG
35:CD40LG
18:TNFSF5
6429:IFNB3
6425:IFNB1
6366:IFNA8
6362:IFNA7
6358:IFNA6
6354:IFNA5
6350:IFNA4
6346:IFNA2
6342:IFNA1
5753:KITLG
5741:Other
5727:IL17A
5686:IL1F9
5681:IL1F8
5676:IL1F7
5671:IL1F6
5666:IL1F5
5603:IFNW1
5593:IFNB1
5558:IFNA8
5553:IFNA7
5548:IFNA6
5543:IFNA5
5538:IFNA4
5533:IFNA2
5528:IFNA1
5407:Other
5310:gp130
5299:GMCSF
5079:CX3CL
5030:CXCL9
5020:CXCL7
5015:CXCL6
5010:CXCL5
5005:CXCL4
5000:CXCL3
4995:CXCL2
4989:CXCL1
4973:CCL28
4968:CCL27
4963:CCL26
4958:CCL25
4953:CCL24
4948:CCL23
4943:CCL22
4938:CCL21
4933:CCL20
4928:CCL19
4922:CCL18
4917:CCL17
4912:CCL16
4907:CCL15
4902:CCL14
4897:CCL13
4892:CCL12
4887:CCL11
4845:/MCP1
4762:CD350
4757:CD349
4752:CD344
4747:CD340
4742:CD339
4737:CD338
4732:CD337
4727:CD336
4722:CD335
4717:CD334
4712:CD333
4707:CD332
4702:CD331
4697:CD329
4692:CD328
4687:CD327
4682:CD326
4677:CD325
4672:CD324
4667:CD322
4662:CD321
4657:CD320
4652:CD318
4647:CD317
4642:CD316
4637:CD315
4632:CD314
4627:CD312
4622:CD309
4617:CD307
4612:CD306
4607:CD305
4602:CD304
4597:CD303
4592:CD302
4587:CD301
4566:CD299
4561:CD298
4556:CD297
4551:CD295
4546:CD294
4536:CD292
4531:CD290
4526:CD289
4521:CD288
4516:CD286
4511:CD284
4506:CD283
4501:CD282
4496:CD281
4491:CD280
4486:CD279
4481:CD278
4476:CD276
4471:CD275
4466:CD274
4461:CD273
4456:CD272
4451:CD271
4446:CD269
4441:CD268
4436:CD267
4431:CD266
4426:CD265
4421:CD264
4416:CD263
4411:CD262
4406:CD261
4401:CD258
4396:CD257
4391:CD256
4386:CD254
4381:CD253
4376:CD252
4360:CD249
4355:CD248
4351:CD247
4346:CD246
4341:CD244
4336:CD243
4331:CD241
4316:CD239
4311:CD238
4306:CD236
4289:CD235
4284:CD234
4279:CD233
4274:CD230
4269:CD229
4264:CD228
4259:CD227
4254:CD226
4249:CD225
4244:CD224
4239:CD223
4234:CD222
4229:CD221
4224:CD220
4209:CD218
4204:CD217
4182:CD212
4160:CD209
4155:CD208
4150:CD207
4145:CD206
4140:CD205
4135:CD204
4125:CD201
4109:CD200
4094:CD197
4089:CD196
4084:CD195
4079:CD194
4074:CD193
4069:CD192
4064:CD191
4059:CD186
4054:CD185
4049:CD184
4044:CD183
4039:CD182
4034:CD181
4029:CD180
4012:CD179
4007:CD178
4002:CD177
3997:CD174
3975:CD172
3970:CD171
3965:CD170
3960:CD169
3955:CD168
3938:CD167
3933:CD166
3928:CD164
3923:CD163
3918:CD162
3913:CD161
3908:CD160
3891:CD159
3861:CD158
3856:CD157
3834:CD156
3829:CD155
3824:CD154
3819:CD153
3814:CD152
3809:CD151
3793:CD150
3788:CD148
3783:CD147
3778:CD146
3773:CD144
3768:CD143
3763:CD142
3758:CD141
3748:CD138
3743:CD137
3738:CD136
3733:CD135
3728:CD134
3723:CD133
3718:CD132
3713:CD131
3708:CD130
3703:CD129
3698:CD127
3693:CD126
3688:CD125
3683:CD124
3678:CD123
3673:CD122
3656:CD121
3639:CD120
3634:CD119
3629:CD118
3624:CD117
3619:CD116
3614:CD115
3609:CD114
3604:CD113
3599:CD112
3594:CD111
3589:CD110
3584:CD109
3579:CD108
3562:CD107
3557:CD106
3552:CD105
3547:CD104
3542:CD103
3537:CD102
3532:CD101
3516:CD100
2572:S2CID
2436:S2CID
2399:S2CID
2362:S2CID
2115:S2CID
2064:S2CID
1929:S2CID
1867:(PDF)
1856:(PDF)
1830:49539
1776:S2CID
1662:S2CID
1446:with
1337:cells
1275:IFN-γ
1144:CD40L
1136:CD154
877:21947
837:Mouse
832:Human
803:Amigo
452:blood
420:Mouse
413:Human
360:Start
295:Mouse
259:Start
192:Human
155:88337
6868:TYK2
6810:JAK3
6722:JAK2
6659:JAK1
6624:here
6622:See
6604:here
6602:See
6595:TGFβ
6584:here
6582:See
6560:here
6252:here
6250:See
5939:here
5937:See
5873:IL13
5868:IL10
5837:TNFβ
5832:IFNγ
5804:TNFA
5785:cell
5765:SPP1
5723:IL25
5719:IL17
5621:IFNG
5598:IFNK
5484:IL26
5479:IL24
5474:IL20
5469:IL19
5464:IL22
5460:IL10
5429:IL34
5424:IL32
5419:IL16
5414:IL14
5398:IL35
5393:IL27
5388:IL23
5383:IL12
5359:CTF1
5354:CNTF
5338:IL31
5333:IL30
5328:IL27
5323:IL11
5271:IL21
5256:IL13
5247:IL15
5129:TNFA
5107:XCL2
5102:XCL1
4982:CXCL
4882:CCL9
4877:CCL8
4872:CCL7
4867:CCL6
4861:CCL5
4855:CCL4
4849:CCL3
4843:CCL2
4838:CCL1
3511:CD99
3506:CD98
3501:CD97
3496:CD96
3491:CD95
3486:CD94
3481:CD93
3476:CD92
3472:CD91
3467:CD90
3462:CD89
3457:CD88
3452:CD87
3447:CD86
3410:CD85
3405:CD84
3400:CD83
3395:CD82
3390:CD81
3385:CD80
3368:CD79
3363:CD78
3358:CD74
3353:CD73
3348:CD72
3343:CD71
3338:CD70
3333:CD69
3328:CD68
3291:CD66
3269:CD64
3264:CD63
3242:CD62
3237:CD61
3232:CD59
3227:CD58
3222:CD57
3217:CD56
3212:CD55
3207:CD54
3202:CD53
3197:CD52
3192:CD51
3176:CD50
3139:CD49
3134:CD48
3129:CD47
3124:CD46
3119:CD45
3114:CD44
3109:CD43
3082:CD42
3077:CD41
3072:CD40
3067:CD39
3062:CD38
3057:CD37
3052:CD36
3047:CD35
3042:CD34
3037:CD33
3020:CD32
3015:CD31
3010:CD30
3005:CD29
3000:CD28
2995:CD27
2990:CD26
2985:CD25
2980:CD24
2975:CD23
2970:CD22
2965:CD21
2960:CD20
2955:CD19
2950:CD18
2933:CD16
2928:CD15
2923:CD14
2918:CD13
2891:CD11
2886:CD10
2783:1–50
2723:1i9r
2708:1aly
2607:PMID
2597:ISBN
2564:PMID
2535:PMID
2506:PMID
2471:PMID
2461:ISBN
2428:PMID
2391:PMID
2354:PMID
2321:PMID
2290:ISBN
2254:PMID
2205:PMID
2156:PMID
2107:PMID
2056:PMID
2021:PMID
1964:PMID
1921:PMID
1835:PMID
1768:PMID
1725:PMID
1654:PMID
1618:PMID
1577:PMID
1406:and
1370:and
1362:and
1349:IL-4
1345:cell
1286:CD40
1168:α5β1
1160:CD40
403:Bgee
351:Band
312:Chr.
250:Band
209:Chr.
143:OMIM
100:3QD6
96:3LKJ
92:1I9R
88:1ALY
69:RCSB
66:PDBe
6642:JAK
6615:TNF
5950:CSF
5863:IL6
5858:IL5
5853:IL4
5799:IL1
5770:MIF
5349:LIF
5344:OSM
5318:IL6
5294:IL5
5289:IL3
5266:IL9
5261:IL7
5252:IL4
5243:IL2
5201:EDA
5121:TNF
5095:XCL
4991:/KC
4831:CCL
2881:CD9
2869:CD8
2864:CD7
2859:CD6
2854:CD5
2849:CD4
2827:CD3
2822:CD2
2795:a-c
2790:CD1
2589:doi
2556:doi
2527:doi
2496:doi
2492:185
2453:doi
2420:doi
2383:doi
2346:doi
2313:doi
2244:PMC
2236:doi
2232:181
2195:PMC
2187:doi
2146:doi
2142:108
2099:doi
2087:378
2048:doi
2044:155
2011:PMC
2003:doi
1956:doi
1911:PMC
1901:doi
1825:PMC
1815:doi
1760:doi
1748:357
1715:PMC
1707:doi
1703:175
1646:doi
1642:152
1608:doi
1604:149
1567:PMC
1559:doi
1555:175
1378:or
1294:TNF
1279:CD4
1162:on
1142:or
858:959
518:hip
373:End
272:End
175:OMA
151:MGI
59:PDB
6975::
6427:,
6388:,
6384:,
6380:,
6376:,
6372:,
6368:,
6364:,
6360:,
6356:,
6352:,
6348:,
6344:,
5649::
5613:II
4806::
4353:-
3474:-
2815:1E
2810:1D
2805:1B
2800:1A
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2562:.
2552:11
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2533:.
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2521:.
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2490:.
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2377:.
2360:.
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2019:.
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1989:.
1985:.
1962:.
1952:16
1950:.
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1919:.
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1530:.
1512:.
1483:^
1462:^
1450:.
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1335:FH
1214:.
1188:FH
1184:FH
1182:(T
805:/
379:bp
366:bp
278:bp
265:bp
173:;
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165:;
163:56
161::
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3296:a
3284:C
3279:B
3274:A
3257:P
3252:L
3247:E
3169:f
3164:e
3159:d
3154:c
3149:b
3144:a
3102:d
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3087:a
3030:B
3025:A
2943:B
2938:A
2911:d
2906:c
2901:b
2896:a
2874:a
2842:ε
2837:δ
2832:γ
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1341:T
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