356:
333:
230:
255:
4752:
4662:
4767:
4722:
4677:
4692:
4647:
4707:
4737:
607:
4632:
362:
261:
31:
1400:
3285:"Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38"
1374:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms complexes with other
2213:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
3723:
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B,
57:
1395:
activation. cIAP1 can ubiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
3198:
Gallagher E, Enzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, et al. (January 2007). "Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production".
1391:, and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of
4029:
Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H (July 2000).
2214:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
3367:"Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase"
4084:"Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1"
2393:
Yamamoto H, Kishimoto T, Minamoto S (November 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27".
4807:
2439:"CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase"
4751:
5672:
4661:
4766:
3449:"The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily"
4425:"TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation"
5456:
3408:"Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif"
3151:"Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain"
4721:
5042:
2311:"4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB"
1841:
Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR (October 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)".
4676:
4691:
4646:
4706:
4800:
1938:
Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000).
369:
268:
5688:
4736:
6150:
3921:
Bonnard M, Mirtsos C, Suzuki S, Graham K, Huang J, Ng M, ItiΓ© A, Wakeham A, Shahinian A, Henzel WJ, Elia AJ, Shillinglaw W, Mak TW, Cao Z, Yeh WC (September 2000).
5616:
2046:"Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors"
5738:
5379:
5286:
5107:
4257:
Carpentier I, Coornaert B, Beyaert R (October 2008). "Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation".
3326:"TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related"
4525:
Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators".
2934:"A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase"
6170:
4793:
1443:
3110:"Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40"
2741:"The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF"
5798:
5449:
1085:
191:
1066:
5035:
1515:
6141:
6130:
6106:
5596:
1984:"The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex"
2358:
Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS (January 1998). "Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B".
5485:
4631:
2603:
Malinin NL, Boldin MP, Kovalenko AV, Wallach D (February 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1".
5632:
5442:
4611:
1716:
4474:"Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain"
1698:
6525:
5764:
5316:
5148:
5028:
3632:
Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak TW, Yagita H, Okumura K, Yeh WC, Nakano H (September 2001).
2437:
Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K (May 1998).
4384:"Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway"
54:
4843:
3546:"Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins"
1293:
355:
5496:
5196:
4824:
3063:
Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (October 1999).
6450:
3244:"TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway"
1300:
1375:
TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-ΞΊB. The protein complex formed by TRAF2 and
332:
3829:
Nomura F, Kawai T, Nakanishi K, Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation".
2975:"Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice"
5276:
5271:
5119:
4919:
1786:
3724:
Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".
2687:
Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J (June 2000).
5201:
4294:"Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis"
1685:
1664:
6161:
5863:
4939:
1681:
254:
229:
3972:"The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation"
3634:"Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death"
1660:
6465:
4785:
171:
5253:
1739:"Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor"
1417:
1404:
4032:"TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation"
368:
267:
6455:
6097:
5190:
4832:
4335:"A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction"
3024:"A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2"
361:
260:
6056:
5526:
5419:
4604:
1886:"Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways"
5353:
2539:"Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40"
1623:
1130:
179:
3490:"Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase"
3923:"Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription"
5809:
5505:
5263:
5089:
3242:
Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (April 2000).
2265:
Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK (July 2001).
1111:
5521:
6194:
5387:
1940:"Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein"
1380:
4169:"TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways"
3874:"NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase"
3673:
Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR, Vadas MA (March 2002).
2893:"Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors"
6006:
6001:
5952:
5245:
5071:
1575:
5591:
5606:
4760:: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE N-TERMINAL DOMAIN OF TRADD AND THE TRAF DOMAIN OF TRAF2
3065:"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction"
6121:
5957:
5662:
5556:
4670:: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE TRAF DOMAIN OF HUMAN TRAF2 AND AN LMP1 BINDING PEPTIDE
4597:
3983:
3783:
2550:
2491:
2223:
2171:
2057:
1995:
1800:
Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (September 1998).
1563:
243:
158:
6364:
6072:
5962:
5854:
5571:
5566:
5561:
5551:
5054:
4472:
Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ (October 2000).
2795:"PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination"
1272:
1225:
5825:
5683:
5652:
4775:: CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF2 IN A COMPLEX WITH A PEPTIDE FROM THE CD40 RECEPTOR
5986:
5981:
5947:
5942:
5888:
5703:
5476:
5468:
5000:
4503:
4364:
4198:
3854:
3749:
3519:
3224:
3004:
2873:
2718:
2628:
2419:
2247:
2195:
1866:
203:
6475:
5779:
5769:
5759:
5693:
5642:
4218:"Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b"
1276:
1251:
1221:
1200:
6404:
6394:
6384:
6321:
6046:
5749:
6414:
6399:
6316:
6281:
6026:
5531:
5465:
4577:
4542:
4495:
4454:
4405:
4356:
4315:
4274:
4239:
4190:
4146:
4105:
4061:
4011:
3952:
3903:
3846:
3811:
3741:
3696:
3655:
3611:
3567:
3511:
3470:
3429:
3388:
3347:
3306:
3265:
3216:
3180:
3131:
3086:
3045:
2996:
2955:
2914:
2865:
2824:
2770:
2710:
2669:
2620:
2578:
2519:
2460:
2411:
2375:
2340:
2288:
2239:
2187:
2137:
2085:
2023:
1961:
1915:
1858:
1823:
1768:
151:
47:
6341:
5516:
4125:"ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5"
3772:"I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction"
3590:"TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex"
6067:
5996:
5991:
5879:
5536:
4730:: STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2) IN COMPLEX WITH A HUMAN OX40 PEPTIDE
4567:
4534:
4485:
4444:
4436:
4395:
4346:
4305:
4266:
4229:
4180:
4136:
4095:
4051:
4043:
4001:
3991:
3942:
3934:
3893:
3885:
3838:
3801:
3791:
3733:
3686:
3675:"Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling"
3645:
3601:
3557:
3501:
3460:
3419:
3378:
3337:
3296:
3255:
3208:
3170:
3162:
3121:
3105:
3076:
3035:
2986:
2945:
2904:
2855:
2814:
2806:
2760:
2752:
2700:
2659:
2612:
2568:
2558:
2509:
2499:
2450:
2403:
2367:
2330:
2322:
2278:
2231:
2179:
2127:
2119:
2075:
2065:
2013:
2003:
1951:
1905:
1897:
1850:
1813:
1758:
1750:
448:
379:
323:
278:
5975:
606:
199:
6445:
6422:
5967:
5884:
5647:
4820:
3488:
Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH (January 1999).
2689:"The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways"
423:
4685:: STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 17-RESIDUE CD40 PEPTIDE
4700:: STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RESIDUE CD40 PEPTIDE
3987:
3787:
2554:
2495:
2227:
2175:
2061:
1999:
6306:
6296:
6223:
5840:
5830:
5754:
5586:
4934:
4892:
4816:
4449:
4424:
4056:
4031:
3898:
3873:
2819:
2794:
2132:
2107:
1910:
1885:
1763:
1738:
1473:
986:
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
30:
4538:
4490:
4473:
4400:
4383:
4351:
4334:
4185:
4168:
3947:
3922:
3606:
3589:
3506:
3489:
3260:
3243:
3175:
3150:
3040:
3023:
2991:
2974:
2860:
2843:
2705:
2688:
2664:
2647:
2335:
2310:
1818:
1801:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
668:
663:
658:
653:
648:
6519:
5874:
5657:
5576:
5338:
4853:
4655:: STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A PEPTIDE FROM TNF-R2
4006:
3971:
3842:
3806:
3771:
2765:
2756:
2740:
2573:
2538:
2514:
2479:
2080:
2045:
2018:
1983:
635:
4715:: STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A HUMAN CD30 PEPTIDE
4507:
4202:
3753:
3523:
3228:
2877:
2722:
2423:
1870:
6480:
6460:
6379:
6369:
6311:
6258:
6188:
6087:
6031:
5718:
5708:
5698:
5601:
5581:
5546:
5541:
5176:
5155:
5097:
4368:
3858:
3008:
2632:
2251:
2199:
441:
220:
183:
2810:
886:
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
207:
6490:
6485:
6389:
6374:
6346:
6336:
6331:
6286:
6253:
6248:
6243:
6238:
6233:
6218:
6213:
6036:
6021:
6016:
5835:
5820:
5637:
5397:
5005:
4745:: STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A M4-1BB PEPTIDE
4234:
4217:
3342:
3325:
2407:
1721:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1703:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1569:
956:
activation of cysteine-type endopeptidase activity involved in apoptotic process
5434:
4382:
Tsao DH, McDonagh T, Telliez JB, Hsu S, Malakian K, Xu GY, Lin LL (June 2000).
4333:
Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H (June 2000).
4270:
3938:
3889:
2123:
524:
6326:
6228:
6082:
5627:
5079:
5020:
2973:
Yan M, Zhang Z, Brady JR, Schilbach S, Fairbrother WJ, Dixit VM (March 2002).
1491:
946:
regulation of extrinsic apoptotic signaling pathway via death domain receptors
340:
237:
187:
5343:
4141:
4124:
4100:
4083:
4082:
Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997).
3770:
Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (August 1996).
3562:
3545:
3465:
3448:
3383:
3366:
3301:
3284:
3081:
3064:
2478:
McWhirter SM, Pullen SS, Holton JM, Crute JJ, Kehry MR, Alber T (July 1999).
2455:
2438:
2108:"The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases"
2008:
1956:
1939:
6500:
6495:
6276:
5723:
5311:
5306:
5236:
5165:
5160:
5143:
5062:
5051:
4914:
3996:
3796:
3424:
3407:
2504:
2480:"Crystallographic analysis of CD40 recognition and signaling by human TRAF2"
2070:
1587:
1533:
1030:
673:
584:
462:
407:
394:
306:
293:
195:
4581:
4572:
4555:
4546:
4499:
4440:
4409:
4360:
4319:
4310:
4293:
4278:
4243:
4065:
3956:
3907:
3850:
3745:
3700:
3691:
3674:
3659:
3650:
3633:
3515:
3433:
3351:
3269:
3220:
3184:
3166:
3135:
3126:
3109:
3090:
3049:
3000:
2959:
2950:
2933:
2918:
2909:
2892:
2828:
2774:
2714:
2563:
2523:
2371:
2292:
2283:
2266:
2243:
2191:
1965:
1919:
1862:
1854:
1399:
4458:
4194:
4150:
4123:
Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ (May 1997).
4109:
4047:
4015:
3815:
3615:
3571:
3474:
3392:
3310:
2869:
2673:
2624:
2582:
2464:
2415:
2379:
2344:
2141:
2089:
2027:
1901:
1827:
1772:
1340:
1335:
5728:
5402:
5358:
4924:
4909:
3324:
Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH (September 1999).
2326:
1605:
1599:
1593:
1449:
1324:
1175:
1156:
2891:
Feng X, Gaeta ML, Madge LA, Yang JH, Bradley JR, Pober JS (March 2001).
2537:
Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (February 1999).
2235:
3447:
Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (Dec 1998).
1611:
1581:
1521:
1497:
1392:
1356:
1142:
1097:
831:
positive regulation of tumor necrosis factor-mediated signaling pathway
1754:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
6301:
6291:
5936:
5932:
5928:
5924:
5920:
5916:
5348:
5333:
5218:
4982:
2616:
1545:
1539:
1527:
1503:
1308:
1052:
3737:
2842:
RΓ©gnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M (July 1997).
2183:
2160:"TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2"
2159:
4292:
Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL (April 2003).
3212:
3022:
Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (January 2002).
5971:
5912:
5908:
5904:
5900:
5896:
5892:
5789:
5412:
5407:
5294:
5213:
4969:
4964:
4959:
4954:
4944:
4929:
4902:
4897:
4872:
2106:
Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (Dec 1997).
1635:
1629:
1617:
1557:
1479:
1461:
1455:
1437:
1431:
1398:
1388:
1384:
1376:
162:, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117
3365:
Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB (August 1998).
1015:
1011:
6356:
6268:
6205:
5392:
5328:
5301:
5138:
5131:
5126:
4987:
4977:
4867:
4862:
3149:
Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M (May 1999).
1884:
Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL (October 2006).
1551:
1509:
1485:
1467:
1425:
1363:
856:
positive regulation of DNA-binding transcription factor activity
175:
5438:
5024:
4789:
4593:
615:
4589:
906:
positive regulation of NF-kappaB transcription factor activity
846:
regulation of tumor necrosis factor-mediated signaling pathway
3588:
Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (April 1996).
2044:
Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL (May 1996).
2648:"Casper is a FADD- and caspase-related inducer of apoptosis"
936:
positive regulation of extrinsic apoptotic signaling pathway
4556:"Tumor necrosis factor receptor-associated factors (TRAFs)"
2844:"Identification and characterization of an IkappaB kinase"
931:
positive regulation of I-kappaB kinase/NF-kappaB signaling
871:
positive regulation of protein homodimerization activity
431:
5597:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
4640:: STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2)
3283:
Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (August 1998).
2739:
Devin A, Lin Y, Yamaoka S, Li Z, Karin M (June 2001).
664:
mitogen-activated protein kinase kinase kinase binding
3406:
Darnay BG, Ni J, Moore PA, Aggarwal BB (March 1999).
1787:"Entrez Gene: TRAF2 TNF receptor-associated factor 2"
596:
1802:"ASK1 is essential for JNK/SAPK activation by TRAF2"
6435:
6413:
6355:
6267:
6204:
6187:
6180:
6160:
6140:
6120:
6096:
6055:
5862:
5853:
5808:
5788:
5737:
5671:
5615:
5504:
5495:
5475:
5378:
5371:
5285:
5262:
5244:
5235:
5174:
5106:
5088:
5070:
5061:
4881:
4852:
4831:
1265:
1244:
1214:
1193:
841:
negative regulation of glial cell apoptotic process
4167:Hsu H, Shu HB, Pan MG, Goeddel DV (January 1996).
1677:
1675:
1673:
1656:
1654:
1652:
2267:"FLASH coordinates NF-kappa B activity via TRAF2"
921:positive regulation of T cell cytokine production
378:
277:
5689:Granulocyte macrophage colony-stimulating factor
1982:Shu HB, Takeuchi M, Goeddel DV (November 1996).
866:activation of NF-kappaB-inducing kinase activity
861:tumor necrosis factor-mediated signaling pathway
3718:
3716:
3714:
3712:
3710:
3627:
3625:
3544:Takeuchi M, Rothe M, Goeddel DV (August 1996).
2932:Cao H, Courchesne WE, Mastick CC (March 2002).
2788:
2786:
2784:
2734:
2732:
2153:
2151:
1933:
1931:
1929:
1407:-R1. Dashed grey lines represent multiple steps
911:positive regulation of interleukin-2 production
891:positive regulation of I-kappaB phosphorylation
4162:
4160:
4077:
4075:
3765:
3763:
3583:
3581:
3539:
3537:
3535:
3533:
2598:
2596:
2594:
2592:
2304:
2302:
2101:
2099:
2039:
2037:
1977:
1975:
1682:GRCm38: Ensembl release 89: ENSMUSG00000026942
5450:
5036:
4801:
4605:
1732:
1730:
8:
2646:Shu HB, Halpin DR, Goeddel DV (June 1997).
1661:GRCh38: Ensembl release 89: ENSG00000127191
1444:Baculoviral IAP repeat-containing protein 3
6456:Leukemia/leukocyte inhibitory factor (LIF)
6201:
6184:
5859:
5501:
5457:
5443:
5435:
5375:
5241:
5112:
5067:
5043:
5029:
5021:
4885:
4808:
4794:
4786:
4612:
4598:
4590:
3970:Song HY, Rothe M, Goeddel DV (June 1996).
3104:Luftig MA, Cahir-McFarland E, Mosialos G,
1026:
836:positive regulation of JUN kinase activity
631:
419:
318:
215:
65:
6451:FMS-like tyrosine kinase 3 ligand (FLT3L)
5880:Interferon alpha (interferon alfa, IFN-Ξ±)
4571:
4489:
4448:
4399:
4350:
4309:
4233:
4184:
4140:
4099:
4055:
4005:
3995:
3946:
3897:
3805:
3795:
3690:
3649:
3605:
3561:
3505:
3464:
3423:
3382:
3341:
3300:
3259:
3174:
3125:
3080:
3039:
2990:
2949:
2908:
2859:
2818:
2764:
2704:
2663:
2572:
2562:
2513:
2503:
2454:
2334:
2282:
2131:
2079:
2069:
2017:
2007:
1955:
1909:
1817:
1762:
1516:Low affinity nerve growth factor receptor
916:death-inducing signaling complex assembly
6473:Additional cytokine receptor modulators:
876:response to endoplasmic reticulum stress
4627:
2158:Li X, Yang Y, Ashwell JD (March 2002).
1648:
6297:Cucurbitacin I (elatericin B, JSI-124)
3872:Pomerantz JL, Baltimore D (Dec 1999).
2793:Li S, Wang L, Dorf ME (January 2009).
729:tumor necrosis factor receptor binding
684:ubiquitin-protein transferase activity
555:crypt of lieberkuhn of small intestine
20:
5633:Granulocyte colony-stimulating factor
4423:Lee SY, Lee SY, Choi Y (April 1997).
4216:Hostager BS, Bishop GA (April 2002).
2309:Arch RH, Thompson CB (January 1998).
1737:Song HY, Donner DB (September 1995).
383:
344:
339:
282:
241:
236:
7:
5992:Interferon kappa (IFN-Ξ΅/ΞΊ/Ο/ΞΆ, IFNK)
5765:Macrophage colony-stimulating factor
6466:Thymic stromal lymphopoietin (TSLP)
4825:signal transducing adaptor proteins
1001:protein-containing complex assembly
971:negative regulation of neuron death
951:I-kappaB kinase/NF-kappaB signaling
785:cytoplasmic side of plasma membrane
5197:Bcl-2 homologous antagonist killer
1262:
1241:
1211:
1190:
1166:
1147:
1121:
1102:
1076:
1057:
734:protein-containing complex binding
601:
519:
457:
436:
14:
1359:that in humans is encoded by the
941:cellular response to nitric oxide
851:protein K63-linked ubiquitination
5277:Tumor necrosis factor receptor 2
5272:Tumor necrosis factor receptor 1
5120:Death-inducing signaling complex
4920:Death-inducing signaling complex
4765:
4750:
4735:
4720:
4705:
4690:
4675:
4660:
4645:
4630:
3843:10.1046/j.1365-2443.2000.00315.x
2757:10.1128/MCB.21.12.3986-3994.2001
1353:TNF receptor-associated factor 2
719:ubiquitin protein ligase binding
605:
367:
360:
354:
331:
266:
259:
253:
228:
29:
5997:Interferon omega (IFN-Ο, IFNW1)
5202:Bcl-2-associated death promoter
826:regulation of apoptotic process
976:programmed necrotic cell death
616:More reference expression data
585:More reference expression data
489:right hemisphere of cerebellum
1:
4554:Bradley JR, Pober JS (2001).
4539:10.1016/S0898-6568(01)00160-7
4491:10.1016/S0092-8674(00)00126-4
4401:10.1016/S1097-2765(00)80270-1
4352:10.1016/S0092-8674(00)80889-2
4259:Biochem. Biophys. Res. Commun
4186:10.1016/S0092-8674(00)80984-8
3607:10.1016/S1074-7613(00)80252-6
3507:10.1016/S0014-5793(98)01731-1
3261:10.1016/s1097-2765(00)80244-0
3041:10.1016/s1097-2765(01)00434-8
2992:10.1016/s0960-9822(02)00687-5
2861:10.1016/S0092-8674(00)80344-X
2706:10.1016/s0960-9822(00)00512-1
2665:10.1016/S1074-7613(00)80450-1
2360:Biochem. Biophys. Res. Commun
1819:10.1016/s1097-2765(00)80283-x
996:protein heterooligomerization
352:
251:
18:Protein-coding gene in humans
3976:Proc. Natl. Acad. Sci. U.S.A
3776:Proc. Natl. Acad. Sci. U.S.A
2811:10.1016/j.molcel.2008.11.023
2543:Proc. Natl. Acad. Sci. U.S.A
2484:Proc. Natl. Acad. Sci. U.S.A
2050:Proc. Natl. Acad. Sci. U.S.A
1988:Proc. Natl. Acad. Sci. U.S.A
6526:Genes on human chromosome 9
5841:Thrombopoietin (THPO, MGDF)
5607:Pegol sihematide (EPO-018B)
5527:Carbamylated erythropoietin
5254:Tumor necrosis factor alpha
4235:10.4049/jimmunol.168.7.3318
3343:10.4049/jimmunol.163.6.3279
2408:10.4049/jimmunol.161.9.4753
709:protein phosphatase binding
6542:
4844:JAK-STAT signaling pathway
4271:10.1016/j.bbrc.2008.07.103
966:protein autoubiquitination
810:protein-containing complex
674:signal transducer activity
473:mucosa of transverse colon
6390:Tofacitinib (tasocitinib)
6347:Tofacitinib (tasocitinib)
6254:Tofacitinib (tasocitinib)
5420:Apoptosis-inducing factor
5115:
4996:
4888:
4625:
1717:"Mouse PubMed Reference:"
1699:"Human PubMed Reference:"
1339:
1334:
1330:
1323:
1307:
1294:Chr 9: 136.88 β 136.93 Mb
1288:
1269:
1248:
1237:
1218:
1197:
1186:
1173:
1169:
1154:
1150:
1141:
1128:
1124:
1109:
1105:
1096:
1083:
1079:
1064:
1060:
1051:
1036:
1029:
1025:
1009:
901:protein catabolic process
896:regulation of JNK cascade
881:protein homotrimerization
694:identical protein binding
634:
630:
613:
604:
595:
582:
531:
522:
469:
460:
430:
422:
418:
401:
388:
351:
330:
321:
317:
300:
287:
250:
227:
218:
214:
169:
166:
156:
149:
144:
73:
68:
51:
46:
41:
37:
28:
23:
6068:Interferon gamma (IFN-Ξ³)
4142:10.1074/jbc.272.21.13471
4101:10.1074/jbc.272.22.14029
3939:10.1093/emboj/19.18.4976
3890:10.1093/emboj/18.23.6694
3563:10.1074/jbc.271.33.19935
3466:10.1074/jbc.273.51.34120
3384:10.1074/jbc.273.32.20551
3302:10.1074/jbc.273.35.22681
3082:10.1074/jbc.274.42.30202
2456:10.1074/jbc.273.21.13353
2124:10.1093/emboj/16.23.6914
2009:10.1073/pnas.93.24.13973
1957:10.1074/jbc.275.15.11114
1624:TRAF interacting protein
1416:TRAF2 has been shown to
991:protein deubiquitination
760:ubiquitin ligase complex
5968:Interferon beta (IFN-Ξ²)
3997:10.1073/pnas.93.13.6721
3797:10.1073/pnas.93.16.8241
3425:10.1074/jbc.274.12.7724
3155:Genes & Development
2505:10.1073/pnas.96.15.8408
2071:10.1073/pnas.93.10.4974
1301:Chr 2: 25.41 β 25.44 Mb
790:IRE1-TRAF2-ASK1 complex
6446:Cardiotrophin 1 (CT-1)
4856:receptor-bound protein
4573:10.1038/sj.onc.1204788
4441:10.1084/jem.185.7.1275
4311:10.1074/jbc.M208672200
3692:10.1074/jbc.M111423200
3651:10.1074/jbc.M104837200
3167:10.1101/gad.13.10.1297
3127:10.1074/jbc.C100103200
2951:10.1074/jbc.C100661200
2910:10.1074/jbc.M007116200
2564:10.1073/pnas.96.4.1234
2372:10.1006/bbrc.1997.8016
2284:10.1074/jbc.M102941200
1855:10.1038/sj.onc.1202975
1408:
926:protein ubiquitination
714:protein kinase binding
543:mesenteric lymph nodes
6443:Additional cytokines:
6370:Decernotinib (VX-509)
6007:Peginterferon alfa-2b
6002:Peginterferon alfa-2a
5522:Asialo erythropoietin
4048:10.1084/jem.192.1.137
1902:10.1083/jcb.200604129
1576:TANK-binding kinase 1
1403:Signaling pathway of
1402:
780:CD40 receptor complex
659:CD40 receptor binding
485:cerebellar hemisphere
5958:Interferon alfacon-1
5587:Erythropoietin (EPO)
2327:10.1128/MCB.18.1.558
724:transferase activity
699:thioesterase binding
649:sphingolipid binding
346:Chromosome 2 (mouse)
244:Chromosome 9 (human)
69:List of PDB id codes
42:Available structures
6105:See IL-28R (IFNLR)
6073:Interferon gamma 1b
5963:Interferon alpha-n3
3988:1996PNAS...93.6721S
3788:1996PNAS...93.8241R
2555:1999PNAS...96.1234T
2496:1999PNAS...96.8408M
2236:10.1038/nature04209
2228:2005Natur.437.1173R
2176:2002Natur.416..345L
2062:1996PNAS...93.4974U
2000:1996PNAS...9313973S
1379:interacts with the
961:signal transduction
750:TRAF2-GSTP1 complex
501:ganglionic eminence
6461:Oncostatin M (OSM)
5987:Interferon beta 1b
5982:Interferon beta 1a
5953:Interferon alfa n1
5948:Interferon alfa 2b
5943:Interferon alfa 2a
5777:Kinase inhibitors:
1409:
1131:ENSMUSG00000026942
819:Biological process
743:Cellular component
642:Molecular function
6513:
6512:
6509:
6508:
6431:
6430:
6198:
6116:
6115:
5849:
5848:
5592:Erythropoietin-Fc
5466:Cytokine receptor
5432:
5431:
5428:
5427:
5367:
5366:
5231:
5230:
5227:
5226:
5055:signaling pathway
5018:
5017:
5014:
5013:
4783:
4782:
3685:(10): 7996β8003.
3201:Nature Immunology
1755:10.1042/bj3090825
1350:
1349:
1346:
1345:
1319:
1318:
1284:
1283:
1259:
1258:
1233:
1232:
1208:
1207:
1182:
1181:
1163:
1162:
1137:
1136:
1118:
1117:
1092:
1091:
1073:
1072:
1021:
1020:
981:apoptotic process
755:AIP1-IRE1 complex
679:metal ion binding
626:
625:
622:
621:
591:
590:
578:
577:
559:intestinal villus
547:lactiferous gland
516:
515:
414:
413:
313:
312:
208:TRAF2 - orthologs
140:
139:
136:
135:
52:Ortholog search:
6533:
6202:
6192:
6185:
6044:Decoy receptors:
5860:
5537:Darbepoetin alfa
5502:
5459:
5452:
5445:
5436:
5376:
5242:
5113:
5068:
5045:
5038:
5031:
5022:
4886:
4821:carrier proteins
4810:
4803:
4796:
4787:
4769:
4754:
4739:
4724:
4709:
4694:
4679:
4664:
4649:
4634:
4614:
4607:
4600:
4591:
4585:
4575:
4550:
4512:
4511:
4493:
4469:
4463:
4462:
4452:
4420:
4414:
4413:
4403:
4379:
4373:
4372:
4354:
4330:
4324:
4323:
4313:
4289:
4283:
4282:
4254:
4248:
4247:
4237:
4213:
4207:
4206:
4188:
4164:
4155:
4154:
4144:
4120:
4114:
4113:
4103:
4094:(22): 14029β32.
4079:
4070:
4069:
4059:
4026:
4020:
4019:
4009:
3999:
3967:
3961:
3960:
3950:
3918:
3912:
3911:
3901:
3884:(23): 6694β704.
3869:
3863:
3862:
3826:
3820:
3819:
3809:
3799:
3767:
3758:
3757:
3720:
3705:
3704:
3694:
3670:
3664:
3663:
3653:
3629:
3620:
3619:
3609:
3585:
3576:
3575:
3565:
3556:(33): 19935β42.
3541:
3528:
3527:
3509:
3485:
3479:
3478:
3468:
3444:
3438:
3437:
3427:
3403:
3397:
3396:
3386:
3362:
3356:
3355:
3345:
3321:
3315:
3314:
3304:
3295:(35): 22681β92.
3280:
3274:
3273:
3263:
3239:
3233:
3232:
3195:
3189:
3188:
3178:
3161:(10): 1297β308.
3146:
3140:
3139:
3129:
3101:
3095:
3094:
3084:
3060:
3054:
3053:
3043:
3019:
3013:
3012:
2994:
2970:
2964:
2963:
2953:
2929:
2923:
2922:
2912:
2888:
2882:
2881:
2863:
2839:
2833:
2832:
2822:
2790:
2779:
2778:
2768:
2736:
2727:
2726:
2708:
2684:
2678:
2677:
2667:
2643:
2637:
2636:
2617:10.1038/385540a0
2600:
2587:
2586:
2576:
2566:
2534:
2528:
2527:
2517:
2507:
2475:
2469:
2468:
2458:
2434:
2428:
2427:
2390:
2384:
2383:
2355:
2349:
2348:
2338:
2306:
2297:
2296:
2286:
2262:
2256:
2255:
2222:(7062): 1173β8.
2210:
2204:
2203:
2155:
2146:
2145:
2135:
2103:
2094:
2093:
2083:
2073:
2041:
2032:
2031:
2021:
2011:
1979:
1970:
1969:
1959:
1950:(15): 11114β20.
1935:
1924:
1923:
1913:
1881:
1875:
1874:
1838:
1832:
1831:
1821:
1797:
1791:
1790:
1783:
1777:
1776:
1766:
1734:
1725:
1724:
1713:
1707:
1706:
1695:
1689:
1679:
1668:
1658:
1332:
1331:
1303:
1296:
1279:
1263:
1254:
1242:
1238:RefSeq (protein)
1228:
1212:
1203:
1191:
1167:
1148:
1122:
1103:
1077:
1058:
1027:
765:vesicle membrane
669:zinc ion binding
632:
618:
609:
602:
587:
571:ventricular zone
527:
525:Top expressed in
520:
465:
463:Top expressed in
458:
437:
420:
410:
397:
386:
371:
364:
358:
347:
335:
319:
309:
296:
285:
270:
263:
257:
246:
232:
216:
210:
161:
154:
131:
66:
60:
39:
38:
33:
21:
6541:
6540:
6536:
6535:
6534:
6532:
6531:
6530:
6516:
6515:
6514:
6505:
6427:
6423:Deucravacitinib
6409:
6351:
6263:
6191:
6176:
6156:
6136:
6112:
6092:
6051:
5885:Interferon alfa
5845:
5804:
5784:
5733:
5667:
5663:Pegnartograstim
5648:Lipegfilgrastim
5611:
5557:Epoetin epsilon
5491:
5471:
5463:
5433:
5424:
5363:
5281:
5258:
5223:
5209:Anti-apoptotic:
5170:
5102:
5084:
5057:
5049:
5019:
5010:
4992:
4877:
4848:
4827:
4814:
4784:
4779:
4776:
4770:
4761:
4755:
4746:
4740:
4731:
4725:
4716:
4710:
4701:
4695:
4686:
4680:
4671:
4665:
4656:
4650:
4641:
4635:
4621:
4618:
4588:
4566:(44): 6482β91.
4553:
4524:
4520:
4518:Further reading
4515:
4471:
4470:
4466:
4422:
4421:
4417:
4381:
4380:
4376:
4332:
4331:
4327:
4304:(16): 14363β9.
4291:
4290:
4286:
4256:
4255:
4251:
4215:
4214:
4210:
4166:
4165:
4158:
4135:(21): 13471β4.
4122:
4121:
4117:
4081:
4080:
4073:
4028:
4027:
4023:
3969:
3968:
3964:
3933:(18): 4976β85.
3920:
3919:
3915:
3871:
3870:
3866:
3828:
3827:
3823:
3769:
3768:
3761:
3738:10.1038/ncb1086
3722:
3721:
3708:
3672:
3671:
3667:
3644:(39): 36530β4.
3631:
3630:
3623:
3587:
3586:
3579:
3543:
3542:
3531:
3487:
3486:
3482:
3459:(51): 34120β7.
3446:
3445:
3441:
3418:(12): 7724β31.
3405:
3404:
3400:
3377:(32): 20551β5.
3364:
3363:
3359:
3323:
3322:
3318:
3282:
3281:
3277:
3241:
3240:
3236:
3197:
3196:
3192:
3148:
3147:
3143:
3120:(18): 14602β6.
3103:
3102:
3098:
3075:(42): 30202β8.
3062:
3061:
3057:
3021:
3020:
3016:
2972:
2971:
2967:
2931:
2930:
2926:
2890:
2889:
2885:
2841:
2840:
2836:
2792:
2791:
2782:
2751:(12): 3986β94.
2745:Mol. Cell. Biol
2738:
2737:
2730:
2686:
2685:
2681:
2645:
2644:
2640:
2611:(6616): 540β4.
2602:
2601:
2590:
2536:
2535:
2531:
2490:(15): 8408β13.
2477:
2476:
2472:
2449:(21): 13353β8.
2436:
2435:
2431:
2392:
2391:
2387:
2357:
2356:
2352:
2315:Mol. Cell. Biol
2308:
2307:
2300:
2277:(27): 25073β7.
2264:
2263:
2259:
2212:
2211:
2207:
2184:10.1038/416345a
2170:(6878): 345β7.
2157:
2156:
2149:
2118:(23): 6914β25.
2105:
2104:
2097:
2043:
2042:
2035:
1994:(24): 13973β8.
1981:
1980:
1973:
1937:
1936:
1927:
1883:
1882:
1878:
1849:(42): 5814β20.
1840:
1839:
1835:
1799:
1798:
1794:
1785:
1784:
1780:
1749:(Pt 3): 825β9.
1736:
1735:
1728:
1715:
1714:
1710:
1697:
1696:
1692:
1680:
1671:
1659:
1650:
1646:
1641:
1414:
1383:family members
1372:
1341:View/Edit Mouse
1336:View/Edit Human
1299:
1292:
1289:Location (UCSC)
1275:
1271:
1250:
1224:
1220:
1199:
1112:ENSG00000127191
1005:
814:
738:
689:protein binding
614:
583:
574:
569:
565:
561:
557:
553:
549:
545:
541:
537:
523:
512:
507:
503:
499:
495:
491:
487:
483:
479:
475:
461:
405:
392:
384:
374:
373:
372:
365:
345:
322:Gene location (
304:
291:
283:
273:
272:
271:
264:
242:
219:Gene location (
170:
157:
150:
75:
53:
19:
12:
11:
5:
6539:
6537:
6529:
6528:
6518:
6517:
6511:
6510:
6507:
6506:
6504:
6503:
6498:
6493:
6488:
6483:
6478:
6469:
6468:
6463:
6458:
6453:
6448:
6439:
6437:
6433:
6432:
6429:
6428:
6426:
6425:
6419:
6417:
6411:
6410:
6408:
6407:
6402:
6397:
6392:
6387:
6382:
6377:
6372:
6367:
6365:Cercosporamide
6361:
6359:
6353:
6352:
6350:
6349:
6344:
6339:
6334:
6329:
6324:
6319:
6314:
6309:
6307:Deuruxolitinib
6304:
6299:
6294:
6289:
6284:
6279:
6273:
6271:
6265:
6264:
6262:
6261:
6256:
6251:
6246:
6241:
6236:
6231:
6226:
6224:Deuruxolitinib
6221:
6216:
6210:
6208:
6199:
6182:
6178:
6177:
6175:
6174:
6166:
6164:
6158:
6157:
6155:
6154:
6146:
6144:
6138:
6137:
6135:
6134:
6126:
6124:
6118:
6117:
6114:
6113:
6111:
6110:
6102:
6100:
6098:IFNLR (Ξ», III)
6094:
6093:
6091:
6090:
6085:
6076:
6075:
6070:
6061:
6059:
6053:
6052:
6050:
6049:
6040:
6039:
6034:
6029:
6024:
6019:
6010:
6009:
6004:
5999:
5994:
5989:
5984:
5979:
5965:
5960:
5955:
5950:
5945:
5940:
5882:
5877:
5868:
5866:
5864:IFNAR (Ξ±/Ξ², I)
5857:
5851:
5850:
5847:
5846:
5844:
5843:
5838:
5833:
5831:Promegapoietin
5828:
5823:
5814:
5812:
5810:Thrombopoietin
5806:
5805:
5803:
5802:
5794:
5792:
5786:
5785:
5783:
5782:
5773:
5772:
5767:
5762:
5757:
5755:Interleukin-34
5752:
5743:
5741:
5735:
5734:
5732:
5731:
5726:
5721:
5712:
5711:
5706:
5701:
5696:
5691:
5686:
5677:
5675:
5669:
5668:
5666:
5665:
5660:
5655:
5650:
5645:
5640:
5635:
5630:
5621:
5619:
5613:
5612:
5610:
5609:
5604:
5599:
5594:
5589:
5584:
5579:
5574:
5569:
5564:
5559:
5554:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5510:
5508:
5506:Erythropoietin
5499:
5493:
5492:
5490:
5489:
5481:
5479:
5473:
5472:
5464:
5462:
5461:
5454:
5447:
5439:
5430:
5429:
5426:
5425:
5423:
5422:
5416:
5415:
5410:
5405:
5400:
5395:
5390:
5384:
5382:
5373:
5369:
5368:
5365:
5364:
5362:
5361:
5356:
5351:
5346:
5341:
5336:
5331:
5326:
5320:
5319:
5314:
5309:
5304:
5298:
5297:
5291:
5289:
5283:
5282:
5280:
5279:
5274:
5268:
5266:
5260:
5259:
5257:
5256:
5250:
5248:
5239:
5233:
5232:
5229:
5228:
5225:
5224:
5222:
5221:
5216:
5211:
5205:
5204:
5199:
5193:
5188:
5186:Pro-apoptotic:
5182:
5180:
5172:
5171:
5169:
5168:
5163:
5158:
5152:
5151:
5146:
5141:
5135:
5134:
5129:
5123:
5122:
5116:
5110:
5104:
5103:
5101:
5100:
5094:
5092:
5086:
5085:
5083:
5082:
5076:
5074:
5065:
5059:
5058:
5050:
5048:
5047:
5040:
5033:
5025:
5016:
5015:
5012:
5011:
5009:
5008:
5003:
4997:
4994:
4993:
4991:
4990:
4985:
4980:
4975:
4974:
4973:
4967:
4962:
4957:
4952:
4947:
4937:
4932:
4927:
4922:
4917:
4912:
4907:
4906:
4905:
4900:
4889:
4883:
4879:
4878:
4876:
4875:
4870:
4865:
4859:
4857:
4850:
4849:
4847:
4846:
4837:
4835:
4829:
4828:
4817:Cell signaling
4815:
4813:
4812:
4805:
4798:
4790:
4781:
4780:
4778:
4777:
4771:
4764:
4762:
4756:
4749:
4747:
4741:
4734:
4732:
4726:
4719:
4717:
4711:
4704:
4702:
4696:
4689:
4687:
4681:
4674:
4672:
4666:
4659:
4657:
4651:
4644:
4642:
4636:
4629:
4626:
4623:
4622:
4619:
4617:
4616:
4609:
4602:
4594:
4587:
4586:
4551:
4533:(6): 389β400.
4521:
4519:
4516:
4514:
4513:
4464:
4435:(7): 1275β85.
4415:
4374:
4325:
4284:
4249:
4228:(7): 3318β22.
4208:
4179:(2): 299β308.
4156:
4115:
4071:
4021:
3982:(13): 6721β5.
3962:
3913:
3864:
3837:(3): 191β202.
3821:
3782:(16): 8241β6.
3759:
3726:Nat. Cell Biol
3706:
3665:
3621:
3577:
3529:
3500:(3): 297β302.
3480:
3439:
3398:
3357:
3336:(6): 3279β85.
3316:
3275:
3234:
3213:10.1038/ni1421
3190:
3141:
3096:
3055:
3014:
2965:
2944:(11): 8771β4.
2924:
2903:(11): 8341β9.
2883:
2834:
2780:
2728:
2679:
2638:
2588:
2529:
2470:
2429:
2385:
2350:
2298:
2257:
2205:
2147:
2095:
2056:(10): 4974β8.
2033:
1971:
1925:
1876:
1833:
1792:
1778:
1726:
1708:
1690:
1669:
1647:
1645:
1642:
1640:
1639:
1633:
1627:
1621:
1615:
1609:
1603:
1597:
1591:
1585:
1579:
1573:
1567:
1561:
1555:
1549:
1543:
1537:
1531:
1525:
1519:
1513:
1507:
1501:
1495:
1489:
1483:
1477:
1471:
1465:
1459:
1453:
1447:
1441:
1435:
1429:
1422:
1413:
1410:
1371:
1368:
1348:
1347:
1344:
1343:
1338:
1328:
1327:
1321:
1320:
1317:
1316:
1314:
1312:
1305:
1304:
1297:
1290:
1286:
1285:
1282:
1281:
1267:
1266:
1260:
1257:
1256:
1246:
1245:
1239:
1235:
1234:
1231:
1230:
1216:
1215:
1209:
1206:
1205:
1195:
1194:
1188:
1184:
1183:
1180:
1179:
1171:
1170:
1164:
1161:
1160:
1152:
1151:
1145:
1139:
1138:
1135:
1134:
1126:
1125:
1119:
1116:
1115:
1107:
1106:
1100:
1094:
1093:
1090:
1089:
1081:
1080:
1074:
1071:
1070:
1062:
1061:
1055:
1049:
1048:
1043:
1038:
1034:
1033:
1023:
1022:
1019:
1018:
1007:
1006:
1004:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
822:
820:
816:
815:
813:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
746:
744:
740:
739:
737:
736:
731:
726:
721:
716:
711:
706:
704:enzyme binding
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
645:
643:
639:
638:
628:
627:
624:
623:
620:
619:
611:
610:
599:
593:
592:
589:
588:
580:
579:
576:
575:
573:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
532:
529:
528:
517:
514:
513:
511:
510:
506:
502:
498:
494:
490:
486:
482:
478:
474:
470:
467:
466:
454:
453:
445:
434:
428:
427:
424:RNA expression
416:
415:
412:
411:
403:
399:
398:
390:
387:
382:
376:
375:
366:
359:
353:
349:
348:
343:
337:
336:
328:
327:
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
240:
234:
233:
225:
224:
212:
211:
168:
164:
163:
155:
147:
146:
142:
141:
138:
137:
134:
133:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
6538:
6527:
6524:
6523:
6521:
6502:
6499:
6497:
6494:
6492:
6489:
6487:
6484:
6482:
6479:
6477:
6474:
6471:
6470:
6467:
6464:
6462:
6459:
6457:
6454:
6452:
6449:
6447:
6444:
6441:
6440:
6438:
6434:
6424:
6421:
6420:
6418:
6416:
6412:
6406:
6403:
6401:
6398:
6396:
6393:
6391:
6388:
6386:
6383:
6381:
6378:
6376:
6373:
6371:
6368:
6366:
6363:
6362:
6360:
6358:
6354:
6348:
6345:
6343:
6340:
6338:
6335:
6333:
6330:
6328:
6325:
6323:
6320:
6318:
6315:
6313:
6310:
6308:
6305:
6303:
6300:
6298:
6295:
6293:
6290:
6288:
6285:
6283:
6280:
6278:
6275:
6274:
6272:
6270:
6266:
6260:
6257:
6255:
6252:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6227:
6225:
6222:
6220:
6217:
6215:
6212:
6211:
6209:
6207:
6203:
6200:
6196:
6190:
6186:
6183:
6179:
6172:
6168:
6167:
6165:
6163:
6159:
6152:
6148:
6147:
6145:
6143:
6139:
6132:
6128:
6127:
6125:
6123:
6119:
6108:
6104:
6103:
6101:
6099:
6095:
6089:
6086:
6084:
6081:
6078:
6077:
6074:
6071:
6069:
6066:
6063:
6062:
6060:
6058:
6057:IFNGR (Ξ³, II)
6054:
6048:
6045:
6042:
6041:
6038:
6035:
6033:
6030:
6028:
6025:
6023:
6020:
6018:
6015:
6012:
6011:
6008:
6005:
6003:
6000:
5998:
5995:
5993:
5990:
5988:
5985:
5983:
5980:
5977:
5973:
5969:
5966:
5964:
5961:
5959:
5956:
5954:
5951:
5949:
5946:
5944:
5941:
5938:
5934:
5930:
5926:
5922:
5918:
5914:
5910:
5906:
5902:
5898:
5894:
5890:
5886:
5883:
5881:
5878:
5876:
5875:Albinterferon
5873:
5870:
5869:
5867:
5865:
5861:
5858:
5856:
5852:
5842:
5839:
5837:
5834:
5832:
5829:
5827:
5824:
5822:
5819:
5816:
5815:
5813:
5811:
5807:
5800:
5796:
5795:
5793:
5791:
5787:
5781:
5778:
5775:
5774:
5771:
5768:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5745:
5744:
5742:
5740:
5736:
5730:
5727:
5725:
5722:
5720:
5717:
5714:
5713:
5710:
5707:
5705:
5702:
5700:
5697:
5695:
5692:
5690:
5687:
5685:
5682:
5679:
5678:
5676:
5674:
5673:GM-CSF (CSF2)
5670:
5664:
5661:
5659:
5658:Pegfilgrastim
5656:
5654:
5651:
5649:
5646:
5644:
5641:
5639:
5636:
5634:
5631:
5629:
5626:
5623:
5622:
5620:
5618:
5614:
5608:
5605:
5603:
5600:
5598:
5595:
5593:
5590:
5588:
5585:
5583:
5580:
5578:
5577:Epoetin theta
5575:
5573:
5572:Epoetin omega
5570:
5568:
5567:Epoetin kappa
5565:
5563:
5562:Epoetin gamma
5560:
5558:
5555:
5553:
5552:Epoetin delta
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5512:
5511:
5509:
5507:
5503:
5500:
5498:
5494:
5487:
5483:
5482:
5480:
5478:
5474:
5470:
5467:
5460:
5455:
5453:
5448:
5446:
5441:
5440:
5437:
5421:
5418:
5417:
5414:
5411:
5409:
5406:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5385:
5383:
5381:
5380:Intracellular
5377:
5374:
5370:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5321:
5318:
5315:
5313:
5310:
5308:
5305:
5303:
5300:
5299:
5296:
5293:
5292:
5290:
5288:
5287:Intracellular
5284:
5278:
5275:
5273:
5270:
5269:
5267:
5265:
5261:
5255:
5252:
5251:
5249:
5247:
5243:
5240:
5238:
5234:
5220:
5217:
5215:
5212:
5210:
5207:
5206:
5203:
5200:
5198:
5194:
5192:
5189:
5187:
5184:
5183:
5181:
5179:
5178:
5173:
5167:
5164:
5162:
5159:
5157:
5154:
5153:
5150:
5147:
5145:
5142:
5140:
5137:
5136:
5133:
5130:
5128:
5125:
5124:
5121:
5118:
5117:
5114:
5111:
5109:
5108:Intracellular
5105:
5099:
5096:
5095:
5093:
5091:
5087:
5081:
5078:
5077:
5075:
5073:
5069:
5066:
5064:
5060:
5056:
5053:
5046:
5041:
5039:
5034:
5032:
5027:
5026:
5023:
5007:
5004:
5002:
4999:
4998:
4995:
4989:
4986:
4984:
4981:
4979:
4976:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4942:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4916:
4913:
4911:
4908:
4904:
4901:
4899:
4896:
4895:
4894:
4891:
4890:
4887:
4884:
4880:
4874:
4871:
4869:
4866:
4864:
4861:
4860:
4858:
4855:
4854:Growth factor
4851:
4845:
4842:
4839:
4838:
4836:
4834:
4830:
4826:
4822:
4818:
4811:
4806:
4804:
4799:
4797:
4792:
4791:
4788:
4774:
4768:
4763:
4759:
4753:
4748:
4744:
4738:
4733:
4729:
4723:
4718:
4714:
4708:
4703:
4699:
4693:
4688:
4684:
4678:
4673:
4669:
4663:
4658:
4654:
4648:
4643:
4639:
4633:
4628:
4624:
4615:
4610:
4608:
4603:
4601:
4596:
4595:
4592:
4583:
4579:
4574:
4569:
4565:
4561:
4557:
4552:
4548:
4544:
4540:
4536:
4532:
4528:
4523:
4522:
4517:
4509:
4505:
4501:
4497:
4492:
4487:
4484:(2): 351β61.
4483:
4479:
4475:
4468:
4465:
4460:
4456:
4451:
4446:
4442:
4438:
4434:
4430:
4426:
4419:
4416:
4411:
4407:
4402:
4397:
4394:(6): 1051β7.
4393:
4389:
4385:
4378:
4375:
4370:
4366:
4362:
4358:
4353:
4348:
4345:(7): 777β87.
4344:
4340:
4336:
4329:
4326:
4321:
4317:
4312:
4307:
4303:
4299:
4298:J. Biol. Chem
4295:
4288:
4285:
4280:
4276:
4272:
4268:
4264:
4260:
4253:
4250:
4245:
4241:
4236:
4231:
4227:
4223:
4219:
4212:
4209:
4204:
4200:
4196:
4192:
4187:
4182:
4178:
4174:
4170:
4163:
4161:
4157:
4152:
4148:
4143:
4138:
4134:
4130:
4129:J. Biol. Chem
4126:
4119:
4116:
4111:
4107:
4102:
4097:
4093:
4089:
4088:J. Biol. Chem
4085:
4078:
4076:
4072:
4067:
4063:
4058:
4053:
4049:
4045:
4042:(1): 137β43.
4041:
4037:
4033:
4025:
4022:
4017:
4013:
4008:
4003:
3998:
3993:
3989:
3985:
3981:
3977:
3973:
3966:
3963:
3958:
3954:
3949:
3944:
3940:
3936:
3932:
3928:
3924:
3917:
3914:
3909:
3905:
3900:
3895:
3891:
3887:
3883:
3879:
3875:
3868:
3865:
3860:
3856:
3852:
3848:
3844:
3840:
3836:
3832:
3825:
3822:
3817:
3813:
3808:
3803:
3798:
3793:
3789:
3785:
3781:
3777:
3773:
3766:
3764:
3760:
3755:
3751:
3747:
3743:
3739:
3735:
3732:(2): 97β105.
3731:
3727:
3719:
3717:
3715:
3713:
3711:
3707:
3702:
3698:
3693:
3688:
3684:
3680:
3679:J. Biol. Chem
3676:
3669:
3666:
3661:
3657:
3652:
3647:
3643:
3639:
3638:J. Biol. Chem
3635:
3628:
3626:
3622:
3617:
3613:
3608:
3603:
3600:(4): 387β96.
3599:
3595:
3591:
3584:
3582:
3578:
3573:
3569:
3564:
3559:
3555:
3551:
3550:J. Biol. Chem
3547:
3540:
3538:
3536:
3534:
3530:
3525:
3521:
3517:
3513:
3508:
3503:
3499:
3495:
3491:
3484:
3481:
3476:
3472:
3467:
3462:
3458:
3454:
3453:J. Biol. Chem
3450:
3443:
3440:
3435:
3431:
3426:
3421:
3417:
3413:
3412:J. Biol. Chem
3409:
3402:
3399:
3394:
3390:
3385:
3380:
3376:
3372:
3371:J. Biol. Chem
3368:
3361:
3358:
3353:
3349:
3344:
3339:
3335:
3331:
3327:
3320:
3317:
3312:
3308:
3303:
3298:
3294:
3290:
3289:J. Biol. Chem
3286:
3279:
3276:
3271:
3267:
3262:
3257:
3254:(4): 649β58.
3253:
3249:
3245:
3238:
3235:
3230:
3226:
3222:
3218:
3214:
3210:
3206:
3202:
3194:
3191:
3186:
3182:
3177:
3172:
3168:
3164:
3160:
3156:
3152:
3145:
3142:
3137:
3133:
3128:
3123:
3119:
3115:
3114:J. Biol. Chem
3111:
3107:
3100:
3097:
3092:
3088:
3083:
3078:
3074:
3070:
3069:J. Biol. Chem
3066:
3059:
3056:
3051:
3047:
3042:
3037:
3034:(1): 121β31.
3033:
3029:
3025:
3018:
3015:
3010:
3006:
3002:
2998:
2993:
2988:
2985:(5): 409β13.
2984:
2980:
2976:
2969:
2966:
2961:
2957:
2952:
2947:
2943:
2939:
2938:J. Biol. Chem
2935:
2928:
2925:
2920:
2916:
2911:
2906:
2902:
2898:
2897:J. Biol. Chem
2894:
2887:
2884:
2879:
2875:
2871:
2867:
2862:
2857:
2854:(2): 373β83.
2853:
2849:
2845:
2838:
2835:
2830:
2826:
2821:
2816:
2812:
2808:
2804:
2800:
2796:
2789:
2787:
2785:
2781:
2776:
2772:
2767:
2762:
2758:
2754:
2750:
2746:
2742:
2735:
2733:
2729:
2724:
2720:
2716:
2712:
2707:
2702:
2699:(11): 640β8.
2698:
2694:
2690:
2683:
2680:
2675:
2671:
2666:
2661:
2658:(6): 751β63.
2657:
2653:
2649:
2642:
2639:
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2606:
2599:
2597:
2595:
2593:
2589:
2584:
2580:
2575:
2570:
2565:
2560:
2556:
2552:
2549:(4): 1234β9.
2548:
2544:
2540:
2533:
2530:
2525:
2521:
2516:
2511:
2506:
2501:
2497:
2493:
2489:
2485:
2481:
2474:
2471:
2466:
2462:
2457:
2452:
2448:
2444:
2443:J. Biol. Chem
2440:
2433:
2430:
2425:
2421:
2417:
2413:
2409:
2405:
2402:(9): 4753β9.
2401:
2397:
2389:
2386:
2381:
2377:
2373:
2369:
2366:(3): 613β20.
2365:
2361:
2354:
2351:
2346:
2342:
2337:
2332:
2328:
2324:
2321:(1): 558β65.
2320:
2316:
2312:
2305:
2303:
2299:
2294:
2290:
2285:
2280:
2276:
2272:
2271:J. Biol. Chem
2268:
2261:
2258:
2253:
2249:
2245:
2241:
2237:
2233:
2229:
2225:
2221:
2217:
2209:
2206:
2201:
2197:
2193:
2189:
2185:
2181:
2177:
2173:
2169:
2165:
2161:
2154:
2152:
2148:
2143:
2139:
2134:
2129:
2125:
2121:
2117:
2113:
2109:
2102:
2100:
2096:
2091:
2087:
2082:
2077:
2072:
2067:
2063:
2059:
2055:
2051:
2047:
2040:
2038:
2034:
2029:
2025:
2020:
2015:
2010:
2005:
2001:
1997:
1993:
1989:
1985:
1978:
1976:
1972:
1967:
1963:
1958:
1953:
1949:
1945:
1944:J. Biol. Chem
1941:
1934:
1932:
1930:
1926:
1921:
1917:
1912:
1907:
1903:
1899:
1896:(1): 121β33.
1895:
1891:
1887:
1880:
1877:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1837:
1834:
1829:
1825:
1820:
1815:
1812:(3): 389β95.
1811:
1807:
1803:
1796:
1793:
1788:
1782:
1779:
1774:
1770:
1765:
1760:
1756:
1752:
1748:
1744:
1740:
1733:
1731:
1727:
1722:
1718:
1712:
1709:
1704:
1700:
1694:
1691:
1687:
1683:
1678:
1676:
1674:
1670:
1666:
1662:
1657:
1655:
1653:
1649:
1643:
1637:
1634:
1631:
1628:
1625:
1622:
1619:
1616:
1613:
1610:
1607:
1604:
1601:
1598:
1595:
1592:
1589:
1586:
1583:
1580:
1577:
1574:
1571:
1568:
1565:
1562:
1559:
1556:
1553:
1550:
1547:
1544:
1541:
1538:
1535:
1532:
1529:
1526:
1523:
1520:
1517:
1514:
1511:
1508:
1505:
1502:
1499:
1496:
1493:
1490:
1487:
1484:
1481:
1478:
1475:
1472:
1469:
1466:
1463:
1460:
1457:
1454:
1451:
1448:
1445:
1442:
1439:
1436:
1433:
1430:
1427:
1424:
1423:
1421:
1419:
1411:
1406:
1401:
1397:
1394:
1390:
1386:
1382:
1378:
1369:
1367:
1365:
1362:
1358:
1354:
1342:
1337:
1333:
1329:
1326:
1322:
1315:
1313:
1310:
1306:
1302:
1298:
1295:
1291:
1287:
1280:
1278:
1274:
1268:
1264:
1261:
1255:
1253:
1247:
1243:
1240:
1236:
1229:
1227:
1223:
1217:
1213:
1210:
1204:
1202:
1196:
1192:
1189:
1187:RefSeq (mRNA)
1185:
1178:
1177:
1172:
1168:
1165:
1159:
1158:
1153:
1149:
1146:
1144:
1140:
1133:
1132:
1127:
1123:
1120:
1114:
1113:
1108:
1104:
1101:
1099:
1095:
1088:
1087:
1082:
1078:
1075:
1069:
1068:
1063:
1059:
1056:
1054:
1050:
1047:
1044:
1042:
1039:
1035:
1032:
1028:
1024:
1017:
1013:
1008:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
823:
821:
818:
817:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
775:membrane raft
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
747:
745:
742:
741:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
654:lipid binding
652:
650:
647:
646:
644:
641:
640:
637:
636:Gene ontology
633:
629:
617:
612:
608:
603:
600:
598:
594:
586:
581:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
533:
530:
526:
521:
518:
508:
504:
500:
496:
492:
488:
484:
480:
476:
472:
471:
468:
464:
459:
456:
455:
452:
450:
446:
444:
443:
439:
438:
435:
433:
429:
425:
421:
417:
409:
404:
400:
396:
391:
381:
377:
370:
363:
357:
350:
342:
338:
334:
329:
325:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
245:
239:
235:
231:
226:
222:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
165:
160:
153:
148:
143:
132:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
6481:Lestaurtinib
6472:
6442:
6380:Ritlecitinib
6312:Lestaurtinib
6259:Upadacitinib
6088:Fontolizumab
6079:
6064:
6043:
6032:Rontalizumab
6013:
5871:
5826:Pegacaristim
5817:
5776:
5746:
5739:M-CSF (CSF1)
5719:Mavrilimumab
5715:
5709:Sargramostim
5699:Molgramostim
5684:Ecogramostim
5680:
5653:Nartograstim
5624:
5617:G-CSF (CSF3)
5602:Peginesatide
5582:Epoetin zeta
5547:Epoetin beta
5542:Epoetin alfa
5513:
5323:
5208:
5185:
5177:Bcl-2 family
5175:
5156:Cytochrome c
5098:Fas receptor
4949:
4840:
4772:
4757:
4742:
4727:
4712:
4697:
4682:
4667:
4652:
4637:
4563:
4559:
4530:
4527:Cell. Signal
4526:
4481:
4477:
4467:
4432:
4428:
4418:
4391:
4387:
4377:
4342:
4338:
4328:
4301:
4297:
4287:
4265:(4): 752β7.
4262:
4258:
4252:
4225:
4221:
4211:
4176:
4172:
4132:
4128:
4118:
4091:
4087:
4039:
4035:
4024:
3979:
3975:
3965:
3930:
3926:
3916:
3881:
3877:
3867:
3834:
3830:
3824:
3779:
3775:
3729:
3725:
3682:
3678:
3668:
3641:
3637:
3597:
3593:
3553:
3549:
3497:
3493:
3483:
3456:
3452:
3442:
3415:
3411:
3401:
3374:
3370:
3360:
3333:
3329:
3319:
3292:
3288:
3278:
3251:
3247:
3237:
3207:(1): 57β63.
3204:
3200:
3193:
3158:
3154:
3144:
3117:
3113:
3108:(May 2001).
3099:
3072:
3068:
3058:
3031:
3027:
3017:
2982:
2978:
2968:
2941:
2937:
2927:
2900:
2896:
2886:
2851:
2847:
2837:
2805:(1): 30β42.
2802:
2798:
2748:
2744:
2696:
2692:
2682:
2655:
2651:
2641:
2608:
2604:
2546:
2542:
2532:
2487:
2483:
2473:
2446:
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6375:Peficitinib
6337:Ruxolitinib
6332:Peficitinib
6287:Baricitinib
6249:Ruxolitinib
6244:Peficitinib
6239:Oclacitinib
6234:Momelotinib
6219:Baricitinib
6214:Abrocitinib
6122:Interleukin
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6037:Sifalimumab
6022:Faralimomab
6017:Anifrolumab
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5836:Romiplostim
5821:Eltrombopag
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5704:Regramostim
5638:Lenograstim
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4036:J. Exp. Med
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497:left testis
493:granulocyte
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6476:Emfilermin
6327:Pacritinib
6229:Filgotinib
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5855:Interferon
5780:Agerafenib
5770:Mirimostim
5760:Lanimostim
5694:Milodistim
5643:Leridistim
5628:Filgrastim
5469:modulators
5080:Fas ligand
4222:J. Immunol
3330:J. Immunol
2979:Curr. Biol
2693:Curr. Biol
2396:J. Immunol
1688:, May 2017
1667:, May 2017
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1492:Caveolin 1
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6496:Sorafenib
6405:ZM-449829
6395:WHI-P 154
6385:TCS-21311
6322:NSC-33994
6277:Atiprimod
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1434:,
1428:,
326:)
223:)
206::
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