242:
219:
116:
141:
473:
248:
147:
1273:, with similar irritant and desensitization properties, was used as a control for nicotine, to distinguish it from menthol-induced response. The menthol receptor was seen to sensitize or desensitize based on cellular conditions, and menthol produces increased activity in Ca-voltage gated channels that is not seen in ethanol,
1603:, as there are so few treatment options for men with prostate cancer. As an androgen-regulated protein whose function is lost as cancer develops in cells, the TRPM8 protein seems to be especially critical in regulating calcium levels and has recently been proposed as the focus of new drugs used to treat prostate cancer.
1218:
of the menthol receptor). It is hypothesized the TRPV1 and TRPM8 receptors act together in response to inflammatory conditions: TRPV1, by proton action, increases the burning sensation of pain, while the acidity inhibits TRPM8 to block the more pleasant sensation of coolness in more dire instances of
1314:
was known to cross-desensitize with other irritant agonists, where the same information was not known about menthol. The study involved subjects swishing either menthol or capsaicin for an extended time at regular intervals. There were three significant conclusions about cross-desensitizing: 1) Both
1543:
temperatures. Remarkably, these animals are deficient in many diverse aspects of cold signaling, including cool and noxious cold perception, injury-evoked sensitization to cold, and cooling-induced analgesia. These animals provide a great deal of insight into the molecular signaling pathways that
1239:
two-way crossover study by applying 40% L-menthol to the forearm, using ethanol as a control. Activation of the TRPM8-receptor channel (the primary menthol receptor channel) resulted in increased sensitization to the menthol stimulus. To investigate the mechanisms of this sensitization, Wasner
1332:
In a search for compounds that activated the TRPM8 cold receptor, compounds that produce a cooling-sensation were sought out from the fragrance industries. Of 70 relevant compounds, the following 10 produced the associated -increase response in mTRPM8-transfected HEK293 cells used to identify
1168:
receptor to maintain a feasible threshold temperature range in which our cells are comfortable and our perception of these stimuli occurs at the spinal cord and brain, which integrate signals from different fibers of varying sensitivity to temperature. Application of menthol to skin or mucous
1570:
TRPM8 upregulation in bladder tissues correlates with pain in patients with painful bladder syndromes. Furthermore, TRPM8 is upregulated in many prostate cancer cell lines and
Dendreon/Genentech are pursuing an agonist approach to induce apoptosis and prostate cancer cell death.
1829:
Olsen RV, Andersen HH, Møller HG, Eskelund PW, Arendt-Nielsen L (October 2014). "Somatosensory and vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers".
2745:
De
Petrocellis L, Vellani V, Schiano-Moriello A, Marini P, Magherini PC, Orlando P, Di Marzo V (June 2008). "Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8".
1163:
that exposure to cold, 20 °C or cooler, lead to a response in calcium influx. This receptor was shown to respond to both cold temperatures, menthol, and similar now-known agonists of the TRPM8 receptor. It works in conjunction with the
2700:
De
Petrocellis L, Starowicz K, Moriello AS, Vivese M, Orlando P, Di Marzo V (May 2007). "Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids".
1248:
conduction blockade of the superficial radial nerve in another group of subjects. This ended up reducing the menthol-induced sensation of cold and hyperalgesia because blocking A fiber conduction resulted in inhibition of a class of
1269:-containing cigarettes non-smokers, which induced what they classified as an irritant response, after initial sensitization, showed a declining response in subjects over time, lending itself to the incidence of desensitization.
5642:
1555:
Low concentrations of TRPM8 agonists such as menthol (or icilin) found to be antihyperalgesic in certain conditions, whereas high concentrations of menthol caused both cold and mechanical hyperalgesia in healthy volunteers.
1077:
ions into the cell, which leads to depolarization and the generation of an action potential. The signal is conducted from primary afferents (type C- and A-delta) eventually leading to the sensation of cold and cold pain.
1281:, 2001, also claim the cross-desensitization of menthol receptors can occur by unknown molecular mechanisms, though they hypothesize the importance of Ca2+ in reducing cell excitability in a way similar to that in the
3118:
Lashinger ES, Steiginga MS, Hieble JP, Leon LA, Gardner SD, Nagilla R, et al. (September 2008). "AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome".
1264:
As is common in response to many other sensory stimuli, much experimental evidence exists for the desensitization of human response of TRPM8 receptors to menthol. Testing involving administration of menthol and
1021:. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans. In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor).
5635:
3275:
Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of
Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels".
1783:
Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of
Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels".
1587:
dependent Ca channel necessary for prostate cancer cells to survive and grow. Immunofluorescence showed expression of the TRPM8 protein in the ER and plasma membrane of the androgen-responsive
2324:
Dessirier JM, O'Mahony M, Carstens E (May 2001). "Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine".
1544:
participate in the detection of cold and painful stimuli. Many research groups, both in universities and pharmaceutical companies, are now actively involved in looking for selective TRPM8
1057:
region. A range of diverse components are required for the high level of specificity in response to cold and menthol stimuli which eventually lead to ion flow through the protein channel.
1532:) or when ambient temperatures drop below approximately 26 °C (79 °F), suggesting that it mediates the detection of cold thermal stimuli by primary afferent sensory neurons of
1177:, providing evidence for the role of TRPM8 and other TRP receptors to mediate our sensory interaction with the environment in response to cold in the same way as in response to menthol.
5628:
1310:, 1994, performed a study to discover more about the properties of the menthol receptor and whether menthol had the ability to cross-desensitize with other chemical irritant receptors.
2619:
Patel R, Gonçalves L, Newman R, Jiang FL, Goldby A, Reeve J, et al. (April 2014). "Novel TRPM8 antagonist attenuates cold hypersensitivity after peripheral nerve injury in rats".
4183:
5093:
1567:
in rodent models of neuropathic pain. Furthermore, recently it was shown that TRPM8 antagonists are effective in reversing established pain in neuropathic and visceral pain models.
4828:
4080:
4013:
2900:
Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, et al. (July 2007). "The menthol receptor TRPM8 is the principal detector of environmental cold".
2367:
Abe J, Hosokawa H, Sawada Y, Matsumura K, Kobayashi S (2006). "Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8".
255:
154:
1525:
or relief in pain which is caused as result of traumatic injuries. The underlying mechanism of cold-induced analgesia remained obscure until the discovery of TRPM8.
1140:
activation. Central nervous system roles of the receptors include neurite outgrowth, receptor signaling, and excitotoxic cell death resulting from noxious stimuli.
1256:
needed to transduce the sensation of pain. They concluded menthol sensitizes cold-sensitive peripheral C nociceptors and activates cold-specific A delta fibers.
3205:
2469:
Cliff MA, Green BG (March 1996). "Sensitization and desensitization to capsaicin and menthol in the oral cavity: interactions and individual differences".
1001:
3367:
741:
722:
77:
2179:"Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay"
1053:. S5 and S6 and a connecting loop, also part of the structure, make up the pore, a non-selective cation channel which consists of a highly conserved
1539:
Three independent research groups have reported that mice lacking functional TRPM8 gene expression are severely impaired in their ability to detect
5024:
5007:
5002:
4997:
4992:
2121:
McKemy DD, Neuhausser WM, Julius D (March 2002). "Identification of a cold receptor reveals a general role for TRP channels in thermosensation".
5029:
4127:
3399:
1701:
1591:
cell line. TRPM8 was expressed in androgen-insensitive cells, but it was not shown to be needed for their survival. By knockout of TRPM8 with
6657:
6623:
3329:
1683:
1873:
Werkheiser JL, Rawls SM, Cowan A (October 2006). "Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats".
7492:
5651:
5081:
4262:
1147:, 2002 provided some of the first evidence for existence of a cold-activated receptor throughout the mammalian somatosensory system. Using
1105:
7394:
6510:
6250:
4979:
4000:
3416:
1227:
Numerous studies have been published investigating the effect of L-menthol application as a model for TRPM8-sensitization. The primary
941:
241:
4765:
1292:
phosphorylation sites in TRPM8 (wild type serines and threonines replaced by alanine in mutants) reduces the desensitizing response.
1174:
948:
218:
7349:
6485:
6220:
1599:, the necessity of the TRPM8 receptor was shown in the androgen-dependent cancer cells. This has useful implications in terms of
7472:
6785:
5358:
4357:
4135:
3451:
1670:
1649:
7359:
6780:
6775:
6225:
5380:
2662:
DeFalco J, Steiger D, Dourado M, Emerling D, Duncton MA (December 2010). "5-benzyloxytryptamine as an antagonist of TRPM8".
1666:
1563:
not only indicated that TRPM8 is required for cold sensation but also revealed that TRPM8 mediates both cold and mechanical
140:
115:
6760:
6755:
5702:
5589:
3500:
2804:"Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes"
1645:
7468:
6745:
6306:
4955:
3867:
1081:
The TRPM8 protein is expressed in sensory neurons, and it is activated by cold temperatures and cooling agents, such as
57:
5230:
1460:
1401:
of the TRPM8 receptor. These antagonists physically block the receptor for cold and menthol, by binding to the S1-S4
254:
153:
3408:
3392:
1910:"Comparative modeling of the quaternary structure for the human TRPM8 channel and analysis of its binding features"
1316:
7110:
3209:
247:
146:
5874:
5584:
3794:
1485:
1117:
6860:
6770:
6765:
6750:
6567:
6067:
5697:
5692:
5574:
3835:
3711:
3358:
2049:"Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels"
786:
65:
3232:"Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells"
1736:"A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia"
3038:
7051:
6833:
5579:
1450:
1137:
767:
2233:"Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol"
1319:
in response to capsaicin, and, most novelly, 3) capsaicin receptors are sensitized in response to menthol.
7354:
7201:
6918:
6790:
6696:
6062:
5707:
5610:
3602:
3589:
3576:
3556:
3543:
3508:
1612:
1480:
1121:
7497:
7029:
6828:
6113:
5847:
3385:
2802:
De
Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S, et al. (August 2011).
1440:
7056:
7409:
7230:
7172:
7101:
7009:
6962:
6397:
6260:
6198:
6178:
6052:
5740:
3483:
3015:
2909:
2568:
2423:
2130:
1962:
1533:
1455:
1245:
1228:
1156:
1034:
129:
44:
7314:
7234:
7176:
7134:
7076:
6844:
6352:
6023:
3377:
3002:
Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, et al. (August 2006).
1495:
1398:
1370:
1362:
1354:
1333:
agonists. Experimentally identified and commonly utilized agonists of the menthol receptor include
1250:
6357:
3354:
1358:
48:, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-6
7439:
7299:
7195:
7061:
6856:
6802:
6367:
6311:
6240:
6041:
5933:
5719:
5666:
4950:
3826:
3473:
3300:
3100:
3051:
2933:
2771:
2644:
2537:
2494:
2392:
2349:
2154:
2103:
1855:
1808:
1765:
1470:
1414:
89:
6490:
924:
903:
877:
856:
7294:
7155:
6550:
6449:
6402:
6332:
2285:"Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors"
2231:
Patel R, Gonçalves L, Leveridge M, Mack SR, Hendrick A, Brice NL, Dickenson AH (October 2014).
1390:
1366:
7399:
7389:
6912:
6500:
6423:
6414:
6245:
6014:
5969:
5959:
5904:
5857:
5657:
3988:
3335:
3325:
3292:
3253:
3187:
3156:"Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations"
3136:
3092:
3043:
2984:
2925:
2882:
2833:
2763:
2718:
2679:
2636:
2596:
2529:
2486:
2451:
2384:
2341:
2306:
2262:
2208:
2146:
2095:
2060:
1988:
1931:
1890:
1847:
1800:
1757:
37:
7414:
3154:
Mukerji G, Yiangou Y, Corcoran SL, Selmer IS, Smith GD, Benham CD, et al. (March 2006).
1231:
finding is that TRPM8 sensitization increases the sensation of cold pain, also known as cold
7324:
7090:
6928:
6392:
6337:
5998:
5682:
4757:
3738:
3317:
3284:
3243:
3177:
3167:
3128:
3082:
3033:
3023:
2974:
2964:
2917:
2872:
2864:
2823:
2815:
2755:
2710:
2671:
2628:
2586:
2576:
2521:
2478:
2441:
2431:
2376:
2333:
2296:
2252:
2244:
2198:
2190:
2138:
2087:
2027:
2019:
1978:
1970:
1921:
1882:
1839:
1792:
1747:
1528:
One research group has reported that TRPM8 is activated by chemical cooling agents (such as
1500:
1289:
334:
265:
209:
164:
6631:
6603:
1298:
inhibits TRPM8, which helps mammals to improve cold tolerance at low ambient temperatures.
472:
85:
7444:
7364:
7167:
7160:
6562:
6555:
6495:
6407:
6275:
6270:
6230:
5777:
5687:
5293:
3433:
1734:
Andersen HH, Olsen RV, Møller HG, Eskelund PW, Gazerani P, Arendt-Nielsen L (March 2014).
1580:
1505:
1435:
1430:
1148:
309:
3069:
Colburn RW, Lubin ML, Stone DJ, Wang Y, Lawrence D, D'Andrea MR, et al. (May 2007).
3019:
2913:
2572:
2427:
2134:
1966:
7191:
7106:
6876:
6798:
6505:
6037:
5944:
5914:
5807:
5715:
5089:
3776:
3182:
3155:
2979:
2952:
2877:
2852:
2828:
2803:
2591:
2556:
2525:
2446:
2411:
2257:
2232:
2203:
2178:
2032:
2023:
2007:
1983:
1950:
1490:
1402:
1170:
1038:
2337:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
601:
596:
591:
575:
570:
565:
560:
555:
550:
545:
529:
524:
519:
514:
7486:
7424:
7404:
6999:
6714:
6545:
6525:
6255:
6143:
5954:
5827:
5744:
5043:
4716:
3371:
2851:
Sikandar S, Patel R, Patel S, Sikander S, Bennett DL, Dickenson AH (September 2013).
2819:
2482:
1752:
1735:
1622:
1560:
1295:
501:
3304:
3104:
3055:
2648:
2541:
2498:
2396:
2353:
1859:
1812:
1769:
1277:
and other irritant controls, suggestive of a specific molecular receptor. Dessirier
69:
7304:
7120:
7080:
7013:
7003:
6994:
6989:
6932:
6890:
6480:
6265:
6174:
6087:
5899:
5894:
5797:
5396:
4787:
2937:
2775:
2158:
2107:
1843:
1600:
1475:
1274:
1236:
1232:
1133:
1030:
327:
106:
3248:
3231:
2078:
Moran MM, Xu H, Clapham DE (June 2004). "TRP ion channels in the nervous system".
3321:
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3070:
2868:
2581:
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1926:
1909:
1886:
93:
7344:
7272:
7256:
7124:
7096:
6979:
6923:
6866:
6852:
6540:
6535:
6475:
6204:
6189:
6184:
6138:
6077:
6004:
5984:
5963:
5924:
5787:
5752:
5326:
5321:
5316:
5311:
5198:
5037:
3412:
3132:
2853:"Genes, molecules and patients--emerging topics to guide clinical pain research"
2714:
1706:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1688:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1549:
1465:
1424:
1419:
1394:
1342:
1152:
1125:
1066:
1054:
2675:
2416:
Proceedings of the
National Academy of Sciences of the United States of America
2248:
2091:
2047:
Sherkheli MA, Gisselmann G, Vogt-Eisele AK, Doerner JF, Hatt H (October 2008).
410:
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7130:
7086:
7070:
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6957:
6823:
6691:
6572:
6418:
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6235:
6194:
6019:
6009:
5994:
5862:
5772:
5306:
4672:
4040:
4008:
3028:
3003:
1510:
1445:
1253:
226:
123:
73:
7449:
7434:
7429:
7379:
7374:
7019:
6938:
6896:
6886:
6123:
5988:
5391:
5301:
2759:
2632:
2436:
1974:
1564:
1522:
1311:
1282:
1195:
1109:
686:
450:
348:
293:
280:
192:
179:
81:
3339:
3296:
3257:
3191:
3140:
3096:
3047:
3004:"Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain"
2988:
2969:
2929:
2886:
2837:
2767:
2722:
2683:
2640:
2600:
2455:
2388:
2345:
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2194:
2150:
2099:
2064:
1992:
1935:
1894:
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1804:
1761:
3172:
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2410:
Zhou W, Yang S, Li B, Nie Y, Luo A, Huang G, et al. (December 2020).
988:
983:
7384:
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7338:
7328:
7318:
7308:
7289:
7277:
7246:
7241:
7205:
7116:
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6908:
6880:
6870:
6848:
6530:
6515:
6439:
6377:
6362:
6322:
6128:
6103:
6056:
6047:
5974:
5940:
5884:
5879:
5841:
5837:
5811:
5801:
5791:
5781:
5767:
5725:
5620:
5404:
4752:
3731:
3726:
3721:
3716:
3648:
3643:
3316:. Handbook of Experimental Pharmacology. Vol. 179. pp. 329–44.
1584:
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831:
812:
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7284:
7250:
7219:
7183:
7041:
7023:
6943:
6900:
6840:
6808:
6674:
6618:
6519:
6470:
6443:
6435:
6382:
6316:
6289:
6132:
6108:
6029:
5978:
5867:
5730:
5531:
5288:
5124:
3625:
3620:
3615:
2953:"Mice left out in the cold: commentary on the phenotype of TRPM8-nulls"
1545:
1529:
1409:
1378:
1374:
1270:
1215:
1207:
1203:
1160:
1082:
1074:
1042:
1011:
798:
753:
6728:
6586:
6157:
3288:
2142:
1796:
7211:
7187:
7145:
7045:
6973:
6812:
6794:
6652:
6613:
6608:
6386:
6372:
6117:
6033:
5928:
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5909:
5888:
5851:
5822:
5817:
5756:
5748:
5734:
5711:
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4932:
4878:
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4527:
4522:
4517:
4409:
4345:
4340:
4335:
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4250:
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4235:
4230:
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4176:
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4161:
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4018:
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3814:
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3660:
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3536:
3531:
3526:
3521:
2177:
Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R (February 2004).
1346:
1211:
1086:
1070:
1046:
956:
708:
5665:
2008:"Selective TRPM8 agonists: a novel group of neurophathic analgesics"
1089:
whereas WS-12 and CPS-369 are the most selective agonists of TRPM8.
7215:
6951:
6947:
6904:
6818:
6587:
6454:
6431:
6071:
5948:
5831:
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5139:
5134:
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5119:
5114:
5109:
5104:
5019:
4963:
4920:
4915:
4910:
4905:
4900:
4895:
4890:
4868:
4863:
4858:
4853:
4848:
4843:
4838:
4819:
4814:
4809:
4804:
4792:
4709:
4704:
4699:
4684:
4622:
4617:
4612:
4603:
4598:
4584:
4579:
4570:
4565:
4560:
4551:
4546:
4537:
4532:
4499:
4494:
4489:
4484:
4475:
4466:
4461:
4456:
4447:
4442:
4437:
4432:
4423:
4418:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4240:
4210:
4205:
4200:
4195:
4166:
4115:
4110:
4105:
4100:
4090:
4085:
4065:
4050:
4045:
3960:
3955:
3950:
3945:
3929:
3909:
3894:
3855:
3850:
3845:
3840:
3748:
3743:
3466:
3461:
3456:
2557:"Borneol Is a TRPM8 Agonist that Increases Ocular Surface Wetness"
1592:
1588:
1350:
1191:
1165:
1113:
2512:
Eccles R (August 1994). "Menthol and related cooling compounds".
1124:. In the peripheral nervous system, TRPs respond to stimuli from
671:
667:
7150:
6984:
6729:
6675:
6636:
6327:
6290:
6158:
5522:
5517:
5512:
5502:
5497:
5492:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5437:
5432:
5427:
5422:
5417:
5412:
5351:
5346:
5341:
5336:
5331:
5237:
5225:
5220:
5215:
5146:
5099:
5063:
5058:
5053:
5048:
4775:
4593:
4151:
3488:
3478:
1617:
1596:
1540:
1199:
1096:, lungs, and bladder where its function is not well understood.
1018:
481:
61:
5624:
5552:
4737:
3983:
3771:
3428:
3381:
1951:"Structural insights into TRPM8 inhibition and desensitization"
5076:
4974:
4095:
4055:
7035:
2283:
Wasner G, Schattschneider J, Binder A, Baron R (May 2004).
1908:
Pedretti A, Marconi C, Bettinelli I, Vistoli G (May 2009).
1108:(TRP) superfamily, which includes the menthol (TRPM8) and
1037:
with six helices (S1–6). The first four, S1–4, act as the
2748:
The
Journal of Pharmacology and Experimental Therapeutics
2621:
The Journal of Pharmacology and Experimental Therapeutics
317:
2412:"Why wild giant pandas frequently roll in horse manure"
2797:
2795:
2793:
2791:
2789:
2787:
2785:
2740:
2738:
2736:
2734:
2732:
2695:
2693:
2048:
1315:
chemicals self-desensitize, 2) menthol receptors can
462:
5652:
1521:
Cold-patches have traditionally been used to induce
7265:
6738:
6727:
6707:
6684:
6673:
6645:
6596:
6585:
6463:
6299:
6288:
6213:
6167:
6156:
6096:
5675:
5664:
5565:
5389:
5278:
5074:
4972:
4948:
4750:
4356:
4261:
4126:
3999:
3866:
3825:
3787:
3499:
3444:
917:
896:
870:
849:
3208:. Dendreon Corporation. 2005-09-21. Archived from
1914:Biochimica et Biophysica Acta (BBA) - Biomembranes
1662:
1660:
1658:
1641:
1639:
1637:
3039:20.500.11820/40bf3f19-c65f-4ffe-a2a3-b6c30357701d
264:
163:
3206:"Dendreon: Targeting Cancer, Transforming Lives"
3121:American Journal of Physiology. Renal Physiology
3071:"Attenuated cold sensitivity in TRPM8 null mice"
3312:Voets T, Owsianik G, Nilius B (2007). "TRPM8".
2555:Chen GL, Lei M, Zhou LP, Zeng B, Zou F (2016).
2278:
2276:
2172:
2170:
2168:
1824:
1822:
2614:
2612:
2610:
1949:Diver MM, Cheng Y, Julius D (September 2019).
1729:
1727:
1725:
1723:
1721:
1719:
1717:
1715:
1667:GRCm38: Ensembl release 89: ENSMUSG00000036251
5636:
3393:
2226:
2224:
2222:
1033:, composed of four identical subunits with a
8:
2664:Bioorganic & Medicinal Chemistry Letters
1579:TRPM8 channels may be a target for treating
1198:) receptor, which is potentiated by low pH,
1155:based approaches, they showed a response in
3314:Transient Receptor Potential (TRP) Channels
2053:Pakistan Journal of Pharmaceutical Sciences
1646:GRCh38: Ensembl release 89: ENSG00000144481
1202:conditions were shown to inhibit the TRPM8
1002:Transient receptor potential cation channel
6735:
6681:
6593:
6296:
6164:
5672:
5643:
5629:
5621:
5562:
5549:
4747:
4734:
3996:
3980:
3784:
3768:
3441:
3425:
3400:
3386:
3378:
3368:United States National Library of Medicine
1069:: upon activation, it allows the entry of
682:
597:sensory perception of temperature stimulus
497:
305:
204:
101:
3357:at the U.S. National Library of Medicine
3247:
3181:
3171:
3086:
3037:
3027:
2978:
2968:
2876:
2827:
2590:
2580:
2445:
2435:
2300:
2256:
2202:
2031:
1982:
1925:
1751:
3366:This article incorporates text from the
2514:The Journal of Pharmacy and Pharmacology
1633:
1169:membranes results directly in membrane
1116:), serve a variety of functions in the
1373:. Traditionally used agonists include
18:
5823:CS gas (2-chlorobenzal malononitrile)
3230:Zhang L, Barritt GJ (November 2004).
2951:Daniels RL, McKemy DD (August 2007).
269:
230:
225:
168:
127:
122:
7:
2006:Sherkheli M.A.; et al. (2007).
1106:transient receptor potential channel
7395:N-(p-Amylcinnamoyl)anthranilic acid
6511:N-(p-Amylcinnamoyl)anthranilic acid
6251:N-(p-Amylcinnamoyl)anthranilic acid
4766:Calcium-activated chloride channels
657:calcium ion transmembrane transport
3836:Amiloride-sensitive cation channel
2526:10.1111/j.2042-7158.1994.tb03871.x
2024:10.1111/j.0014-2956.2007.05861_4.x
1175:voltage-dependent calcium channels
914:
893:
867:
846:
822:
803:
777:
758:
732:
713:
467:
405:
343:
322:
14:
1173:, followed by calcium influx via
1014:that in humans is encoded by the
1004:subfamily M (melastatin) member 8
627:detection of temperature stimulus
515:protein homodimerization activity
2857:European Journal of Pharmacology
2820:10.1111/j.1476-5381.2010.01166.x
1875:European Journal of Pharmacology
1753:10.1002/j.1532-2149.2013.00380.x
1548:to be used as new generation of
647:response to temperature stimulus
602:cellular calcium ion homeostasis
571:external side of plasma membrane
471:
253:
246:
240:
217:
152:
145:
139:
114:
5359:Voltage-dependent anion channel
3452:Inositol trisphosphate receptor
2808:British Journal of Pharmacology
2183:British Journal of Pharmacology
2080:Current Opinion in Neurobiology
1092:TRPM8 is also expressed in the
5381:General bacterial porin family
1844:10.1002/j.1532-2149.2014.494.x
1235:. An experiment was done in a
551:endoplasmic reticulum membrane
546:integral component of membrane
482:More reference expression data
451:More reference expression data
1:
7469:Receptor/signaling modulators
5818:CR gas (dibenzoxazepine; DBO)
3249:10.1158/0008-5472.CAN-04-2146
2338:10.1016/S0031-9384(01)00431-0
1405:domain, preventing response.
1397:and M8-An were identified as
238:
137:
16:Protein-coding gene in humans
3322:10.1007/978-3-540-34891-7_20
3088:10.1016/j.neuron.2007.04.017
2869:10.1016/j.ejphar.2013.01.069
2582:10.1371/journal.pone.0158868
2483:10.1016/0031-9384(95)02089-6
2381:10.1016/j.neulet.2005.12.005
1927:10.1016/j.bbamem.2009.02.007
1887:10.1016/j.ejphar.2006.07.026
7493:Genes on human chromosome 2
7097:Paracetamol (acetaminophen)
6005:Paracetamol (acetaminophen)
5875:Farnesyl thiosalicylic acid
5703:15-Deoxy-Δ-prostaglandin J2
3133:10.1152/ajprenal.90269.2008
2715:10.1016/j.yexcr.2007.01.008
1486:Tetrahydrocannabivarin Acid
1461:Tetrahydrocannabinolic acid
1008:cold and menthol receptor 1
1006:(TRPM8), also known as the
632:protein homotetramerization
7514:
4800:Chloride Channel Accessory
3409:Membrane transport protein
2703:Experimental Cell Research
2676:10.1016/j.bmcl.2010.09.099
2249:10.1016/j.pain.2014.07.022
2092:10.1016/j.conb.2004.05.003
1100:Role in the nervous system
7462:
5606:
5561:
5548:
4746:
4733:
3995:
3979:
3795:Epithelial sodium channel
3783:
3767:
3440:
3424:
3029:10.1016/j.cub.2006.07.061
2471:Physiology & Behavior
2326:Physiology & Behavior
1702:"Mouse PubMed Reference:"
1684:"Human PubMed Reference:"
987:
982:
978:
971:
955:
942:Chr 2: 233.92 – 234.02 Mb
936:
921:
900:
889:
874:
853:
842:
829:
825:
810:
806:
797:
784:
780:
765:
761:
752:
739:
735:
720:
716:
707:
692:
685:
681:
665:
617:protein homotrimerization
500:
496:
479:
470:
461:
448:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
6082:Umbellularia californica
3712:Cation channels of sperm
3359:Medical Subject Headings
1832:European Journal of Pain
1740:European Journal of Pain
530:calcium channel activity
7052:N-Arachidonoyl dopamine
6834:Andrographis paniculata
3277:Pharmacological Reviews
2760:10.1124/jpet.107.134809
2633:10.1124/jpet.113.211243
2437:10.1073/pnas.2004640117
1975:10.1126/science.aax6672
1785:Pharmacological Reviews
1451:N-Arachidonoyl dopamine
1122:central nervous systems
1029:The TRPM8 channel is a
949:Chr 1: 88.21 – 88.32 Mb
652:transmembrane transport
7473:Ion channel modulators
7202:Tetrahydrocannabivarin
6697:Tripterygium wilfordii
6063:Tetrahydrocannabiorcol
2970:10.1186/1744-8069-3-23
2195:10.1038/sj.bjp.0705652
1613:Endocannabinoid system
1481:Tetrahydrocannabivarin
371:pancreatic ductal cell
7030:Lysophosphatidic acid
3788:Constitutively active
3173:10.1186/1471-2490-6-6
1534:afferent nerve fibers
1517:Clinical significance
1441:5-benzyloxytryptamine
1302:Cross-desensitization
1041:and allow binding of
642:calcium ion transport
561:endoplasmic reticulum
7410:Pregnenolone sulfate
7231:Euphorbia resinifera
7173:Euphorbia resinifera
7102:Phenylacetylrinvanil
7062:N-Oleoylethanolamide
7010:Homodihydrocapsaicin
6398:Pregnenolone sulfate
6261:Pregnenolone sulfate
6068:Thiopropanal S-oxide
6053:Tetrahydrocannabinol
5741:Allyl isothiocyanate
3355:TRPM8+protein,+human
2369:Neuroscience Letters
2302:10.1093/brain/awh134
1456:Tetrahydrocannabinol
1157:dorsal root ganglion
1049:and similar channel
1035:transmembrane domain
592:response to stimulus
520:ion channel activity
232:Chromosome 1 (mouse)
130:Chromosome 2 (human)
7315:Cannabigerolic acid
7077:Nordihydrocapsaicin
7038:(acidic conditions)
5555:By gating mechanism
3212:on October 28, 2008
3020:2006CBio...16.1591P
2922:10.1038/nature05910
2914:2007Natur.448..204B
2573:2016PLoSO..1158868C
2428:2020PNAS..11732493Z
2422:(51): 32493–32498.
2135:2002Natur.416...52M
1967:2019Sci...365.1434D
1961:(6460): 1434–1440.
1496:Cannabigerolic acid
1251:group C nerve fiber
1190:In contrast to the
1134:inflammatory agents
421:seminiferous tubule
383:islet of Langerhans
375:trigeminal ganglion
359:right lobe of liver
7278:Vernonia tweediana
6857:African blue basil
6829:Bisandrographolide
6415:Steviol glycosides
6368:Hydroxycitronellal
6114:Dehydroligustilide
5934:Angelica acutiloba
5848:Dehydroligustilide
5082:TRP cation channel
4980:CNG cation channel
4263:Tandem pore domain
3474:Ryanodine receptor
3370:, which is in the
1471:Cannabidiolic acid
1244:, 2004, performed
787:ENSMUSG00000036251
585:Biological process
539:Cellular component
508:Molecular function
7480:
7479:
7458:
7457:
7390:Meclofenamic acid
7196:melegueta peppers
7067:Nonivamide (PAVA)
6803:melegueta peppers
6723:
6722:
6669:
6668:
6581:
6580:
6501:Meclofenamic acid
6424:Stevia rebaudiana
6284:
6283:
6246:Meclofenamic acid
6152:
6151:
6042:melegueta peppers
6015:Phenacyl chloride
5970:N-Methylmaleimide
5960:Methyl salicylate
5905:Hydrogen peroxide
5858:Diallyl disulfide
5720:melegueta peppers
5618:
5617:
5602:
5601:
5598:
5597:
5590:Stretch-activated
5567:Ion channel class
5544:
5543:
5540:
5539:
4729:
4728:
4725:
4724:
4001:Calcium-activated
3989:Potassium channel
3975:
3974:
3971:
3970:
3763:
3762:
3759:
3758:
3331:978-3-540-34889-4
3289:10.1124/pr.57.4.6
2295:(Pt 5): 1159–71.
2143:10.1038/nature719
1797:10.1124/pr.57.4.6
1552:analgesic drugs.
998:
997:
994:
993:
967:
966:
932:
931:
911:
910:
885:
884:
864:
863:
838:
837:
819:
818:
793:
792:
774:
773:
748:
747:
729:
728:
677:
676:
492:
491:
488:
487:
457:
456:
444:
443:
433:cerebellar cortex
402:
401:
300:
299:
199:
198:
94:TRPM8 - orthologs
7505:
7325:Cannabigerovarin
7057:N-Oleoyldopamine
6963:Euodia ruticarpa
6929:Dihydrocapsaicin
6736:
6732:
6682:
6678:
6594:
6590:
6338:Cooling Agent 10
6297:
6293:
6165:
6161:
5683:4-Hydroxynonenal
5673:
5669:
5654:
5645:
5638:
5631:
5622:
5563:
5550:
4758:Chloride channel
4748:
4735:
4128:Inward-rectifier
3997:
3981:
3785:
3769:
3739:Two-pore channel
3442:
3426:
3402:
3395:
3388:
3379:
3343:
3308:
3262:
3261:
3251:
3227:
3221:
3220:
3218:
3217:
3202:
3196:
3195:
3185:
3175:
3151:
3145:
3144:
3115:
3109:
3108:
3090:
3066:
3060:
3059:
3041:
3031:
3014:(16): 1591–605.
2999:
2993:
2992:
2982:
2972:
2948:
2942:
2941:
2897:
2891:
2890:
2880:
2863:(1–3): 188–202.
2848:
2842:
2841:
2831:
2814:(7): 1479–1494.
2799:
2780:
2779:
2754:(3): 1007–1015.
2742:
2727:
2726:
2709:(9): 1911–1920.
2697:
2688:
2687:
2659:
2653:
2652:
2616:
2605:
2604:
2594:
2584:
2552:
2546:
2545:
2509:
2503:
2502:
2466:
2460:
2459:
2449:
2439:
2407:
2401:
2400:
2364:
2358:
2357:
2321:
2315:
2314:
2304:
2280:
2271:
2270:
2260:
2243:(10): 2097–107.
2228:
2217:
2216:
2206:
2174:
2163:
2162:
2118:
2112:
2111:
2075:
2069:
2068:
2044:
2038:
2037:
2035:
2003:
1997:
1996:
1986:
1946:
1940:
1939:
1929:
1905:
1899:
1898:
1870:
1864:
1863:
1826:
1817:
1816:
1780:
1774:
1773:
1755:
1731:
1710:
1709:
1698:
1692:
1691:
1680:
1674:
1664:
1653:
1643:
1595:targeting TRPM8
1501:Cannabigerovarin
1371:Cooling Agent 10
1290:protein kinase C
980:
979:
951:
944:
927:
915:
906:
894:
890:RefSeq (protein)
880:
868:
859:
847:
823:
804:
778:
759:
733:
714:
683:
622:response to cold
607:cation transport
498:
484:
475:
468:
453:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
7513:
7512:
7508:
7507:
7506:
7504:
7503:
7502:
7483:
7482:
7481:
7476:
7454:
7445:Tolfenamic acid
7365:Flufenamic acid
7261:
7168:Resiniferatoxin
7161:Ruta graveolens
6924:Diacyl glycerol
6719:
6703:
6665:
6661:
6641:
6627:
6577:
6563:Tolfenamic acid
6556:Ruta graveolens
6496:Flufenamic acid
6459:
6408:Ruta graveolens
6319:(intracellular)
6280:
6276:Tolfenamic acid
6231:Flufenamic acid
6209:
6185:Diacyl glycerol
6148:
6092:
5778:Cannabichromene
5688:4-Oxo-2-nonenal
5660:
5649:
5619:
5614:
5594:
5557:
5536:
5385:
5284:
5274:
5070:
4968:
4944:
4742:
4721:
4635:
4512:
4369:
4352:
4257:
4221:
4191:
4147:
4139:
4122:
4076:
3991:
3967:
3940:
3879:
3862:
3821:
3779:
3755:
3638:
3610:
3597:
3584:
3564:
3551:
3516:
3495:
3436:
3434:Calcium channel
3420:
3406:
3351:
3346:
3332:
3311:
3274:
3270:
3268:Further reading
3265:
3242:(22): 8365–73.
3236:Cancer Research
3229:
3228:
3224:
3215:
3213:
3204:
3203:
3199:
3153:
3152:
3148:
3117:
3116:
3112:
3068:
3067:
3063:
3008:Current Biology
3001:
3000:
2996:
2950:
2949:
2945:
2908:(7150): 204–8.
2899:
2898:
2894:
2850:
2849:
2845:
2801:
2800:
2783:
2744:
2743:
2730:
2699:
2698:
2691:
2661:
2660:
2656:
2618:
2617:
2608:
2567:(7): e0158868.
2554:
2553:
2549:
2511:
2510:
2506:
2468:
2467:
2463:
2409:
2408:
2404:
2366:
2365:
2361:
2323:
2322:
2318:
2282:
2281:
2274:
2230:
2229:
2220:
2176:
2175:
2166:
2120:
2119:
2115:
2077:
2076:
2072:
2046:
2045:
2041:
2005:
2004:
2000:
1948:
1947:
1943:
1907:
1906:
1902:
1872:
1871:
1867:
1828:
1827:
1820:
1782:
1781:
1777:
1733:
1732:
1713:
1700:
1699:
1695:
1682:
1681:
1677:
1665:
1656:
1644:
1635:
1631:
1609:
1581:prostate cancer
1577:
1519:
1506:Cannabichromene
1403:voltage-sensing
1387:
1330:
1325:
1304:
1288:Mutagenesis of
1262:
1260:Desensitization
1225:
1188:
1183:
1149:calcium imaging
1102:
1063:
1027:
989:View/Edit Mouse
984:View/Edit Human
947:
940:
937:Location (UCSC)
923:
902:
876:
855:
768:ENSG00000144481
661:
580:
576:plasma membrane
534:
525:protein binding
480:
449:
440:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
7511:
7509:
7501:
7500:
7495:
7485:
7484:
7478:
7477:
7463:
7460:
7459:
7456:
7455:
7453:
7452:
7447:
7442:
7437:
7432:
7427:
7422:
7417:
7412:
7407:
7402:
7397:
7392:
7387:
7382:
7377:
7372:
7367:
7362:
7357:
7352:
7347:
7342:
7332:
7322:
7312:
7302:
7297:
7292:
7287:
7282:
7269:
7267:
7263:
7262:
7260:
7259:
7254:
7244:
7239:
7223:
7209:
7199:
7181:
7165:
7153:
7148:
7143:
7138:
7135:Dorrigo pepper
7128:
7114:
7107:Phorbol esters
7104:
7099:
7094:
7084:
7074:
7064:
7059:
7054:
7049:
7039:
7032:
7027:
7017:
7007:
6997:
6992:
6987:
6982:
6977:
6967:
6955:
6941:
6936:
6926:
6921:
6916:
6894:
6884:
6877:Cannabidivarin
6874:
6864:
6845:camphor laurel
6838:
6826:
6821:
6816:
6806:
6788:
6783:
6778:
6773:
6768:
6763:
6758:
6753:
6748:
6742:
6740:
6733:
6725:
6724:
6721:
6720:
6718:
6717:
6711:
6709:
6705:
6704:
6702:
6701:
6688:
6686:
6679:
6671:
6670:
6667:
6666:
6664:
6663:
6659:
6655:
6649:
6647:
6643:
6642:
6640:
6639:
6634:
6629:
6625:
6621:
6616:
6611:
6606:
6600:
6598:
6591:
6583:
6582:
6579:
6578:
6576:
6575:
6570:
6565:
6560:
6548:
6543:
6538:
6533:
6528:
6523:
6513:
6508:
6506:Mefenamic acid
6503:
6498:
6493:
6488:
6483:
6478:
6473:
6467:
6465:
6461:
6460:
6458:
6457:
6452:
6447:
6428:
6412:
6400:
6395:
6390:
6380:
6375:
6370:
6365:
6360:
6355:
6350:
6340:
6335:
6330:
6325:
6320:
6314:
6309:
6303:
6301:
6294:
6286:
6285:
6282:
6281:
6279:
6278:
6273:
6268:
6263:
6258:
6253:
6248:
6243:
6238:
6233:
6228:
6223:
6217:
6215:
6211:
6210:
6208:
6207:
6202:
6199:St John's wort
6192:
6187:
6182:
6179:St John's wort
6171:
6169:
6162:
6154:
6153:
6150:
6149:
6147:
6146:
6141:
6136:
6126:
6121:
6111:
6106:
6100:
6098:
6094:
6093:
6091:
6090:
6085:
6075:
6065:
6060:
6050:
6045:
6027:
6024:Dorrigo pepper
6017:
6012:
6007:
6002:
5992:
5982:
5972:
5967:
5957:
5952:
5945:Sichuan pepper
5938:
5922:
5917:
5915:Isothiocyanate
5912:
5907:
5902:
5897:
5892:
5882:
5877:
5872:
5860:
5855:
5845:
5835:
5825:
5820:
5815:
5808:Cinnamaldehyde
5805:
5795:
5785:
5775:
5770:
5765:
5760:
5738:
5728:
5723:
5705:
5700:
5695:
5690:
5685:
5679:
5677:
5670:
5662:
5661:
5650:
5648:
5647:
5640:
5633:
5625:
5616:
5615:
5607:
5604:
5603:
5600:
5599:
5596:
5595:
5593:
5592:
5587:
5582:
5577:
5571:
5569:
5559:
5558:
5553:
5546:
5545:
5542:
5541:
5538:
5537:
5535:
5534:
5529:
5528:
5527:
5526:
5525:
5520:
5515:
5507:
5506:
5505:
5500:
5495:
5487:
5486:
5485:
5480:
5475:
5470:
5465:
5460:
5455:
5447:
5446:
5445:
5440:
5435:
5430:
5425:
5420:
5415:
5401:
5399:
5387:
5386:
5384:
5383:
5378:
5377:
5376:
5371:
5366:
5356:
5355:
5354:
5349:
5344:
5339:
5334:
5329:
5324:
5319:
5314:
5309:
5298:
5296:
5282:
5276:
5275:
5273:
5272:
5271:
5270:
5265:
5260:
5255:
5250:
5245:
5235:
5234:
5233:
5228:
5218:
5213:
5212:
5211:
5206:
5201:
5191:
5190:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5144:
5143:
5142:
5137:
5132:
5127:
5122:
5117:
5112:
5107:
5097:
5086:
5084:
5072:
5071:
5069:
5068:
5067:
5066:
5061:
5056:
5051:
5046:
5034:
5033:
5032:
5027:
5022:
5012:
5011:
5010:
5005:
5000:
4995:
4984:
4982:
4970:
4969:
4967:
4966:
4960:
4958:
4956:Proton channel
4946:
4945:
4943:
4942:
4941:
4940:
4935:
4925:
4924:
4923:
4918:
4913:
4908:
4903:
4898:
4893:
4883:
4882:
4881:
4876:
4871:
4866:
4861:
4856:
4851:
4846:
4841:
4831:
4826:
4825:
4824:
4823:
4822:
4817:
4812:
4807:
4797:
4796:
4795:
4790:
4780:
4779:
4778:
4762:
4760:
4744:
4743:
4738:
4731:
4730:
4727:
4726:
4723:
4722:
4720:
4719:
4714:
4713:
4712:
4707:
4702:
4692:
4687:
4682:
4681:
4680:
4675:
4670:
4665:
4655:
4654:
4653:
4648:
4643:
4633:
4628:
4627:
4626:
4625:
4620:
4615:
4608:
4607:
4606:
4601:
4596:
4589:
4588:
4587:
4582:
4575:
4574:
4573:
4568:
4563:
4556:
4555:
4554:
4549:
4542:
4541:
4540:
4535:
4530:
4525:
4520:
4510:
4505:
4504:
4503:
4502:
4497:
4492:
4487:
4480:
4479:
4478:
4471:
4470:
4469:
4464:
4459:
4452:
4451:
4450:
4445:
4440:
4435:
4428:
4427:
4426:
4421:
4414:
4413:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4367:
4362:
4360:
4354:
4353:
4351:
4350:
4349:
4348:
4343:
4338:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4293:
4288:
4283:
4278:
4267:
4265:
4259:
4258:
4256:
4255:
4254:
4253:
4248:
4243:
4238:
4233:
4228:
4219:
4215:
4214:
4213:
4208:
4203:
4198:
4189:
4181:
4180:
4179:
4174:
4169:
4164:
4159:
4154:
4145:
4141:
4137:
4132:
4130:
4124:
4123:
4121:
4120:
4119:
4118:
4113:
4108:
4103:
4098:
4093:
4088:
4083:
4074:
4070:
4069:
4068:
4060:
4059:
4058:
4053:
4048:
4038:
4037:
4036:
4031:
4026:
4021:
4016:
4005:
4003:
3993:
3992:
3984:
3977:
3976:
3973:
3972:
3969:
3968:
3966:
3965:
3964:
3963:
3958:
3953:
3948:
3938:
3934:
3933:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3877:
3872:
3870:
3864:
3863:
3861:
3860:
3859:
3858:
3853:
3848:
3843:
3832:
3830:
3823:
3822:
3820:
3819:
3818:
3817:
3812:
3807:
3802:
3791:
3789:
3781:
3780:
3777:Sodium channel
3772:
3765:
3764:
3761:
3760:
3757:
3756:
3754:
3753:
3752:
3751:
3746:
3736:
3735:
3734:
3729:
3724:
3719:
3708:
3707:
3706:
3705:
3700:
3695:
3690:
3680:
3679:
3678:
3673:
3668:
3663:
3653:
3652:
3651:
3646:
3636:
3631:
3630:
3629:
3628:
3623:
3618:
3608:
3600:
3595:
3587:
3582:
3574:
3573:
3572:
3562:
3554:
3549:
3541:
3540:
3539:
3534:
3529:
3524:
3514:
3505:
3503:
3497:
3496:
3494:
3493:
3492:
3491:
3486:
3481:
3471:
3470:
3469:
3464:
3459:
3448:
3446:
3438:
3437:
3429:
3422:
3421:
3407:
3405:
3404:
3397:
3390:
3382:
3363:
3362:
3350:
3349:External links
3347:
3345:
3344:
3330:
3309:
3271:
3269:
3266:
3264:
3263:
3222:
3197:
3146:
3127:(3): F803-10.
3110:
3061:
2994:
2957:Molecular Pain
2943:
2892:
2843:
2781:
2728:
2689:
2670:(23): 7076–9.
2654:
2606:
2547:
2504:
2461:
2402:
2375:(1–2): 140–4.
2359:
2332:(1–2): 25–36.
2316:
2272:
2218:
2164:
2129:(6876): 52–8.
2113:
2070:
2039:
1998:
1941:
1900:
1881:(1–3): 101–5.
1865:
1838:(9): 1333–42.
1818:
1775:
1711:
1693:
1675:
1654:
1632:
1630:
1627:
1626:
1625:
1620:
1615:
1608:
1605:
1583:. TRPM8 is an
1576:
1575:Role in cancer
1573:
1518:
1515:
1514:
1513:
1508:
1503:
1498:
1493:
1491:Cannabidivarin
1488:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1422:
1417:
1412:
1386:
1383:
1329:
1326:
1324:
1321:
1303:
1300:
1261:
1258:
1224:
1221:
1187:
1186:pH-sensitivity
1184:
1182:
1179:
1171:depolarization
1101:
1098:
1062:
1059:
1039:voltage sensor
1026:
1023:
996:
995:
992:
991:
986:
976:
975:
969:
968:
965:
964:
962:
960:
953:
952:
945:
938:
934:
933:
930:
929:
919:
918:
912:
909:
908:
898:
897:
891:
887:
886:
883:
882:
872:
871:
865:
862:
861:
851:
850:
844:
840:
839:
836:
835:
827:
826:
820:
817:
816:
808:
807:
801:
795:
794:
791:
790:
782:
781:
775:
772:
771:
763:
762:
756:
750:
749:
746:
745:
737:
736:
730:
727:
726:
718:
717:
711:
705:
704:
699:
694:
690:
689:
679:
678:
675:
674:
663:
662:
660:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
594:
588:
586:
582:
581:
579:
578:
573:
568:
563:
558:
553:
548:
542:
540:
536:
535:
533:
532:
527:
522:
517:
511:
509:
505:
504:
494:
493:
490:
489:
486:
485:
477:
476:
465:
459:
458:
455:
454:
446:
445:
442:
441:
439:
438:
434:
430:
426:
425:spinal ganglia
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
379:amniotic fluid
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
7510:
7499:
7496:
7494:
7491:
7490:
7488:
7475:
7474:
7470:
7467:
7461:
7451:
7448:
7446:
7443:
7441:
7438:
7436:
7433:
7431:
7428:
7426:
7425:Ruthenium red
7423:
7421:
7418:
7416:
7413:
7411:
7408:
7406:
7405:Niflumic acid
7403:
7401:
7398:
7396:
7393:
7391:
7388:
7386:
7383:
7381:
7378:
7376:
7373:
7371:
7368:
7366:
7363:
7361:
7358:
7356:
7353:
7351:
7348:
7346:
7343:
7340:
7336:
7333:
7330:
7326:
7323:
7320:
7316:
7313:
7310:
7306:
7303:
7301:
7298:
7296:
7293:
7291:
7288:
7286:
7283:
7280:
7279:
7274:
7273:α-Spinasterol
7271:
7270:
7268:
7264:
7258:
7255:
7252:
7248:
7245:
7243:
7240:
7237:
7236:
7232:
7227:
7224:
7221:
7217:
7213:
7210:
7207:
7203:
7200:
7197:
7193:
7189:
7185:
7182:
7179:
7178:
7174:
7169:
7166:
7163:
7162:
7157:
7154:
7152:
7149:
7147:
7144:
7142:
7139:
7136:
7132:
7129:
7126:
7122:
7118:
7115:
7112:
7108:
7105:
7103:
7100:
7098:
7095:
7092:
7088:
7085:
7082:
7078:
7075:
7072:
7068:
7065:
7063:
7060:
7058:
7055:
7053:
7050:
7047:
7043:
7040:
7037:
7033:
7031:
7028:
7025:
7021:
7018:
7015:
7011:
7008:
7005:
7001:
7000:Homocapsaicin
6998:
6996:
6993:
6991:
6988:
6986:
6983:
6981:
6978:
6975:
6971:
6968:
6965:
6964:
6959:
6956:
6953:
6949:
6945:
6942:
6940:
6937:
6934:
6930:
6927:
6925:
6922:
6920:
6917:
6914:
6913:wild bergamot
6910:
6906:
6902:
6898:
6895:
6892:
6888:
6885:
6882:
6878:
6875:
6872:
6868:
6865:
6862:
6861:camphor basil
6858:
6854:
6850:
6846:
6842:
6839:
6836:
6835:
6830:
6827:
6825:
6822:
6820:
6817:
6814:
6810:
6807:
6804:
6800:
6796:
6792:
6789:
6787:
6784:
6782:
6779:
6777:
6774:
6772:
6769:
6767:
6764:
6762:
6759:
6757:
6754:
6752:
6749:
6747:
6744:
6743:
6741:
6737:
6734:
6731:
6726:
6716:
6715:Ruthenium red
6713:
6712:
6710:
6706:
6699:
6698:
6693:
6690:
6689:
6687:
6683:
6680:
6677:
6672:
6662:
6656:
6654:
6651:
6650:
6648:
6644:
6638:
6635:
6633:
6630:
6628:
6622:
6620:
6617:
6615:
6612:
6610:
6607:
6605:
6602:
6601:
6599:
6595:
6592:
6589:
6584:
6574:
6571:
6569:
6566:
6564:
6561:
6558:
6557:
6552:
6549:
6547:
6546:Ruthenium red
6544:
6542:
6539:
6537:
6534:
6532:
6529:
6527:
6526:Niflumic acid
6524:
6521:
6517:
6514:
6512:
6509:
6507:
6504:
6502:
6499:
6497:
6494:
6492:
6489:
6487:
6484:
6482:
6479:
6477:
6474:
6472:
6469:
6468:
6466:
6462:
6456:
6453:
6451:
6448:
6446:; indirectly)
6445:
6441:
6437:
6433:
6429:
6426:
6425:
6420:
6416:
6413:
6410:
6409:
6404:
6401:
6399:
6396:
6394:
6391:
6388:
6384:
6381:
6379:
6376:
6374:
6371:
6369:
6366:
6364:
6361:
6359:
6356:
6354:
6353:Frescolat MGA
6351:
6348:
6344:
6341:
6339:
6336:
6334:
6331:
6329:
6326:
6324:
6321:
6318:
6315:
6313:
6310:
6308:
6305:
6304:
6302:
6298:
6295:
6292:
6287:
6277:
6274:
6272:
6269:
6267:
6264:
6262:
6259:
6257:
6256:Niflumic acid
6254:
6252:
6249:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6218:
6216:
6212:
6206:
6203:
6200:
6196:
6193:
6191:
6188:
6186:
6183:
6180:
6176:
6173:
6172:
6170:
6166:
6163:
6160:
6155:
6145:
6144:Ruthenium red
6142:
6140:
6137:
6134:
6130:
6127:
6125:
6122:
6119:
6115:
6112:
6110:
6107:
6105:
6102:
6101:
6099:
6095:
6089:
6086:
6083:
6079:
6076:
6073:
6069:
6066:
6064:
6061:
6058:
6054:
6051:
6049:
6046:
6043:
6039:
6035:
6031:
6028:
6025:
6021:
6018:
6016:
6013:
6011:
6008:
6006:
6003:
6000:
5996:
5993:
5990:
5986:
5983:
5980:
5976:
5973:
5971:
5968:
5965:
5961:
5958:
5956:
5955:Methylglyoxal
5953:
5950:
5946:
5942:
5939:
5936:
5935:
5930:
5926:
5923:
5921:
5918:
5916:
5913:
5911:
5908:
5906:
5903:
5901:
5898:
5896:
5893:
5890:
5886:
5883:
5881:
5878:
5876:
5873:
5870:
5869:
5864:
5861:
5859:
5856:
5853:
5849:
5846:
5843:
5839:
5836:
5833:
5829:
5828:Cuminaldehyde
5826:
5824:
5821:
5819:
5816:
5813:
5809:
5806:
5803:
5799:
5796:
5793:
5789:
5786:
5783:
5779:
5776:
5774:
5771:
5769:
5766:
5764:
5761:
5758:
5754:
5750:
5746:
5742:
5739:
5736:
5732:
5729:
5727:
5724:
5721:
5717:
5713:
5709:
5706:
5704:
5701:
5699:
5696:
5694:
5691:
5689:
5686:
5684:
5681:
5680:
5678:
5674:
5671:
5668:
5663:
5659:
5656:
5646:
5641:
5639:
5634:
5632:
5627:
5626:
5623:
5613:
5612:
5605:
5591:
5588:
5586:
5585:Voltage-gated
5583:
5581:
5578:
5576:
5573:
5572:
5570:
5568:
5564:
5560:
5556:
5551:
5547:
5533:
5530:
5524:
5521:
5519:
5516:
5514:
5511:
5510:
5508:
5504:
5501:
5499:
5496:
5494:
5491:
5490:
5488:
5484:
5481:
5479:
5476:
5474:
5471:
5469:
5466:
5464:
5461:
5459:
5456:
5454:
5451:
5450:
5448:
5444:
5441:
5439:
5436:
5434:
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5414:
5411:
5410:
5408:
5407:
5406:
5403:
5402:
5400:
5398:
5395:
5393:
5388:
5382:
5379:
5375:
5372:
5370:
5367:
5365:
5362:
5361:
5360:
5357:
5353:
5350:
5348:
5345:
5343:
5340:
5338:
5335:
5333:
5330:
5328:
5325:
5323:
5320:
5318:
5315:
5313:
5310:
5308:
5305:
5304:
5303:
5300:
5299:
5297:
5295:
5292:
5290:
5286:
5277:
5269:
5266:
5264:
5261:
5259:
5256:
5254:
5251:
5249:
5246:
5244:
5241:
5240:
5239:
5236:
5232:
5229:
5227:
5224:
5223:
5222:
5219:
5217:
5214:
5210:
5207:
5205:
5202:
5200:
5197:
5196:
5195:
5192:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5149:
5148:
5145:
5141:
5138:
5136:
5133:
5131:
5128:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5102:
5101:
5098:
5095:
5091:
5088:
5087:
5085:
5083:
5080:
5078:
5073:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5041:
5040:
5039:
5035:
5031:
5028:
5026:
5023:
5021:
5018:
5017:
5016:
5013:
5009:
5006:
5004:
5001:
4999:
4996:
4994:
4991:
4990:
4989:
4986:
4985:
4983:
4981:
4978:
4976:
4971:
4965:
4962:
4961:
4959:
4957:
4954:
4952:
4947:
4939:
4936:
4934:
4931:
4930:
4929:
4926:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4892:
4889:
4888:
4887:
4884:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4836:
4835:
4832:
4830:
4827:
4821:
4818:
4816:
4813:
4811:
4808:
4806:
4803:
4802:
4801:
4798:
4794:
4791:
4789:
4786:
4785:
4784:
4781:
4777:
4774:
4773:
4772:
4769:
4768:
4767:
4764:
4763:
4761:
4759:
4756:
4754:
4749:
4745:
4741:
4740:Miscellaneous
4736:
4732:
4718:
4717:Shaker (gene)
4715:
4711:
4708:
4706:
4703:
4701:
4698:
4697:
4696:
4693:
4691:
4690:minK/ISK-like
4688:
4686:
4683:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4660:
4659:
4656:
4652:
4649:
4647:
4644:
4642:
4639:
4638:
4637:
4630:
4629:
4624:
4621:
4619:
4616:
4614:
4611:
4610:
4609:
4605:
4602:
4600:
4597:
4595:
4592:
4591:
4590:
4586:
4583:
4581:
4578:
4577:
4576:
4572:
4569:
4567:
4564:
4562:
4559:
4558:
4557:
4553:
4550:
4548:
4545:
4544:
4543:
4539:
4536:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4515:
4514:
4507:
4506:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4482:
4481:
4477:
4474:
4473:
4472:
4468:
4465:
4463:
4460:
4458:
4455:
4454:
4453:
4449:
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4430:
4429:
4425:
4422:
4420:
4417:
4416:
4415:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4372:
4371:
4364:
4363:
4361:
4359:
4358:Voltage-gated
4355:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4273:
4272:
4269:
4268:
4266:
4264:
4260:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4234:
4232:
4229:
4227:
4224:
4223:
4222:
4216:
4212:
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4193:
4192:
4185:
4182:
4178:
4175:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4153:
4150:
4149:
4148:
4142:
4140:
4134:
4133:
4131:
4129:
4125:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4078:
4077:
4071:
4067:
4064:
4063:
4061:
4057:
4054:
4052:
4049:
4047:
4044:
4043:
4042:
4039:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4011:
4010:
4007:
4006:
4004:
4002:
3998:
3994:
3990:
3987:
3982:
3978:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3943:
3942:
3935:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3882:
3881:
3874:
3873:
3871:
3869:
3868:Voltage-gated
3865:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3838:
3837:
3834:
3833:
3831:
3828:
3824:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3797:
3796:
3793:
3792:
3790:
3786:
3782:
3778:
3775:
3770:
3766:
3750:
3747:
3745:
3742:
3741:
3740:
3737:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3714:
3713:
3710:
3709:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3685:
3684:
3681:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3658:
3657:
3654:
3650:
3647:
3645:
3642:
3641:
3640:
3633:
3632:
3627:
3624:
3622:
3619:
3617:
3614:
3613:
3612:
3604:
3601:
3599:
3591:
3588:
3586:
3578:
3575:
3571:
3568:
3567:
3566:
3558:
3555:
3553:
3545:
3542:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3519:
3518:
3510:
3507:
3506:
3504:
3502:
3501:Voltage-gated
3498:
3490:
3487:
3485:
3482:
3480:
3477:
3476:
3475:
3472:
3468:
3465:
3463:
3460:
3458:
3455:
3454:
3453:
3450:
3449:
3447:
3443:
3439:
3435:
3432:
3427:
3423:
3418:
3414:
3410:
3403:
3398:
3396:
3391:
3389:
3384:
3383:
3380:
3376:
3375:
3373:
3372:public domain
3369:
3360:
3356:
3353:
3352:
3348:
3341:
3337:
3333:
3327:
3323:
3319:
3315:
3310:
3306:
3302:
3298:
3294:
3290:
3286:
3283:(4): 427–50.
3282:
3278:
3273:
3272:
3267:
3259:
3255:
3250:
3245:
3241:
3237:
3233:
3226:
3223:
3211:
3207:
3201:
3198:
3193:
3189:
3184:
3179:
3174:
3169:
3165:
3161:
3157:
3150:
3147:
3142:
3138:
3134:
3130:
3126:
3122:
3114:
3111:
3106:
3102:
3098:
3094:
3089:
3084:
3081:(3): 379–86.
3080:
3076:
3072:
3065:
3062:
3057:
3053:
3049:
3045:
3040:
3035:
3030:
3025:
3021:
3017:
3013:
3009:
3005:
2998:
2995:
2990:
2986:
2981:
2976:
2971:
2966:
2962:
2958:
2954:
2947:
2944:
2939:
2935:
2931:
2927:
2923:
2919:
2915:
2911:
2907:
2903:
2896:
2893:
2888:
2884:
2879:
2874:
2870:
2866:
2862:
2858:
2854:
2847:
2844:
2839:
2835:
2830:
2825:
2821:
2817:
2813:
2809:
2805:
2798:
2796:
2794:
2792:
2790:
2788:
2786:
2782:
2777:
2773:
2769:
2765:
2761:
2757:
2753:
2749:
2741:
2739:
2737:
2735:
2733:
2729:
2724:
2720:
2716:
2712:
2708:
2704:
2696:
2694:
2690:
2685:
2681:
2677:
2673:
2669:
2665:
2658:
2655:
2650:
2646:
2642:
2638:
2634:
2630:
2626:
2622:
2615:
2613:
2611:
2607:
2602:
2598:
2593:
2588:
2583:
2578:
2574:
2570:
2566:
2562:
2558:
2551:
2548:
2543:
2539:
2535:
2531:
2527:
2523:
2520:(8): 618–30.
2519:
2515:
2508:
2505:
2500:
2496:
2492:
2488:
2484:
2480:
2477:(3): 487–94.
2476:
2472:
2465:
2462:
2457:
2453:
2448:
2443:
2438:
2433:
2429:
2425:
2421:
2417:
2413:
2406:
2403:
2398:
2394:
2390:
2386:
2382:
2378:
2374:
2370:
2363:
2360:
2355:
2351:
2347:
2343:
2339:
2335:
2331:
2327:
2320:
2317:
2312:
2308:
2303:
2298:
2294:
2290:
2286:
2279:
2277:
2273:
2268:
2264:
2259:
2254:
2250:
2246:
2242:
2238:
2234:
2227:
2225:
2223:
2219:
2214:
2210:
2205:
2200:
2196:
2192:
2189:(4): 737–45.
2188:
2184:
2180:
2173:
2171:
2169:
2165:
2160:
2156:
2152:
2148:
2144:
2140:
2136:
2132:
2128:
2124:
2117:
2114:
2109:
2105:
2101:
2097:
2093:
2089:
2085:
2081:
2074:
2071:
2066:
2062:
2058:
2054:
2050:
2043:
2040:
2034:
2029:
2025:
2021:
2017:
2013:
2009:
2002:
1999:
1994:
1990:
1985:
1980:
1976:
1972:
1968:
1964:
1960:
1956:
1952:
1945:
1942:
1937:
1933:
1928:
1923:
1920:(5): 973–82.
1919:
1915:
1911:
1904:
1901:
1896:
1892:
1888:
1884:
1880:
1876:
1869:
1866:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1833:
1825:
1823:
1819:
1814:
1810:
1806:
1802:
1798:
1794:
1791:(4): 427–50.
1790:
1786:
1779:
1776:
1771:
1767:
1763:
1759:
1754:
1749:
1746:(3): 315–25.
1745:
1741:
1737:
1730:
1728:
1726:
1724:
1722:
1720:
1718:
1716:
1712:
1707:
1703:
1697:
1694:
1689:
1685:
1679:
1676:
1672:
1668:
1663:
1661:
1659:
1655:
1651:
1647:
1642:
1640:
1638:
1634:
1628:
1624:
1623:Ruthenium red
1621:
1619:
1616:
1614:
1611:
1610:
1606:
1604:
1602:
1598:
1594:
1590:
1586:
1582:
1574:
1572:
1568:
1566:
1562:
1561:knockout mice
1557:
1553:
1551:
1547:
1542:
1537:
1535:
1531:
1526:
1524:
1516:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1492:
1489:
1487:
1484:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1426:
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1407:
1406:
1404:
1400:
1396:
1392:
1384:
1382:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
1355:Frescolat MGA
1352:
1348:
1344:
1340:
1336:
1327:
1322:
1320:
1318:
1313:
1309:
1301:
1299:
1297:
1296:Caryophyllene
1293:
1291:
1286:
1284:
1280:
1276:
1272:
1268:
1259:
1257:
1255:
1252:
1247:
1243:
1238:
1234:
1230:
1223:Sensitization
1222:
1220:
1217:
1213:
1209:
1205:
1201:
1197:
1193:
1185:
1180:
1178:
1176:
1172:
1167:
1162:
1158:
1154:
1150:
1146:
1141:
1139:
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1107:
1099:
1097:
1095:
1090:
1088:
1084:
1079:
1076:
1072:
1068:
1060:
1058:
1056:
1052:
1048:
1044:
1040:
1036:
1032:
1024:
1022:
1020:
1017:
1013:
1010:(CMR1), is a
1009:
1005:
1003:
990:
985:
981:
977:
974:
970:
963:
961:
958:
954:
950:
946:
943:
939:
935:
928:
926:
920:
916:
913:
907:
905:
899:
895:
892:
888:
881:
879:
873:
869:
866:
860:
858:
852:
848:
845:
843:RefSeq (mRNA)
841:
834:
833:
828:
824:
821:
815:
814:
809:
805:
802:
800:
796:
789:
788:
783:
779:
776:
770:
769:
764:
760:
757:
755:
751:
744:
743:
738:
734:
731:
725:
724:
719:
715:
712:
710:
706:
703:
700:
698:
695:
691:
688:
684:
680:
673:
669:
664:
658:
655:
653:
650:
648:
645:
643:
640:
638:
637:thermoception
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
612:ion transport
610:
608:
605:
603:
600:
598:
595:
593:
590:
589:
587:
584:
583:
577:
574:
572:
569:
567:
566:membrane raft
564:
562:
559:
557:
554:
552:
549:
547:
544:
543:
541:
538:
537:
531:
528:
526:
523:
521:
518:
516:
513:
512:
510:
507:
506:
503:
502:Gene ontology
499:
495:
483:
478:
474:
469:
466:
464:
460:
452:
447:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
7498:Ion channels
7465:
7464:
7305:Cannabigerol
7276:
7229:
7171:
7159:
7121:black pepper
7081:chili pepper
7014:chili pepper
7004:chili pepper
6995:Hepoxilin B3
6990:Hepoxilin A3
6961:
6933:chili pepper
6891:chili pepper
6832:
6695:
6554:
6481:Clotrimazole
6422:
6406:
6358:Frescolat ML
6266:Progesterone
6175:Adhyperforin
6088:WIN 55,212-2
6081:
5932:
5900:Hepoxilin B3
5895:Hepoxilin A3
5866:
5798:Cannabigerol
5608:
5575:Ligand-gated
5566:
5554:
5397:Gap junction
5390:
5279:
5186:
5075:
5036:
5014:
4987:
4973:
4949:
4927:
4885:
4833:
4799:
4782:
4770:
4751:
4739:
4694:
4657:
4631:
4508:
4365:
4270:
4217:
4187:
4143:
4072:
3985:
3936:
3875:
3773:
3682:
3655:
3634:
3606:
3593:
3580:
3560:
3547:
3512:
3445:Ligand-gated
3430:
3413:ion channels
3365:
3364:
3313:
3280:
3276:
3239:
3235:
3225:
3214:. Retrieved
3210:the original
3200:
3163:
3159:
3149:
3124:
3120:
3113:
3078:
3074:
3064:
3011:
3007:
2997:
2960:
2956:
2946:
2905:
2901:
2895:
2860:
2856:
2846:
2811:
2807:
2751:
2747:
2706:
2702:
2667:
2663:
2657:
2627:(1): 47–55.
2624:
2620:
2564:
2560:
2550:
2517:
2513:
2507:
2474:
2470:
2464:
2419:
2415:
2405:
2372:
2368:
2362:
2329:
2325:
2319:
2292:
2288:
2240:
2236:
2186:
2182:
2126:
2122:
2116:
2086:(3): 362–9.
2083:
2079:
2073:
2059:(4): 370–8.
2056:
2052:
2042:
2015:
2012:FEBS Journal
2011:
2001:
1958:
1954:
1944:
1917:
1913:
1903:
1878:
1874:
1868:
1835:
1831:
1788:
1784:
1778:
1743:
1739:
1705:
1696:
1687:
1678:
1601:gene therapy
1578:
1569:
1558:
1554:
1538:
1527:
1520:
1476:Cannabigerol
1388:
1369:, M8-Ag and
1359:Frescolat ML
1331:
1307:
1305:
1294:
1287:
1278:
1275:cyclohexanol
1263:
1241:
1237:double-blind
1233:hyperalgesia
1226:
1206:response to
1189:
1144:
1142:
1103:
1091:
1080:
1065:TRPM8 is an
1064:
1031:homotetramer
1028:
1015:
1007:
1000:
999:
922:
901:
875:
854:
830:
811:
785:
766:
740:
721:
701:
696:
437:spermatocyte
333:
326:
191:234,019,522
178:233,917,373
53:External IDs
7440:Tivanisiran
7345:Capsazepine
7257:Zucapsaicin
7125:long pepper
7091:Pacific yew
6980:GSK1016790A
6867:Cannabidiol
6853:camphorweed
6541:RQ-00203078
6536:PF-05105679
6476:Capsazepine
6241:GSK2293017A
6205:Substance P
6190:GSK1702934A
6139:PF-04745637
6078:Umbellulone
5999:Pacific yew
5985:Oleocanthal
5964:wintergreen
5925:Ligustilide
5788:Cannabidiol
5753:horseradish
5580:Light-gated
4062:IK channel
3160:BMC Urology
2018:(s1): 232.
1550:neuropathic
1466:Cannabidiol
1425:PF-05105679
1420:RQ-00203078
1415:RQ-00434739
1399:antagonists
1395:capsazepine
1385:Antagonists
1343:citronellal
1317:desensitize
1254:nociceptors
1153:patch clamp
1126:temperature
1112:receptors (
1067:ion channel
1055:hydrophobic
395:left testis
391:endometrium
292:88,317,015
279:88,205,383
31:Identifiers
7487:Categories
7335:Cannabinol
7235:pooissonii
7226:Tinyatoxin
7177:pooissonii
7141:Probenecid
7131:Polygodial
7087:Paclitaxel
7071:PAVA spray
6958:Evodiamine
6909:pepperwort
6824:Anandamide
6791:α-Sanshool
6739:Activators
6692:Triptolide
6685:Activators
6597:Activators
6573:TRPM4-IN-5
6491:Elismetrep
6419:stevioside
6347:eucalyptus
6343:Eucalyptol
6307:ADP-ribose
6300:Activators
6236:GSK417651A
6195:Hyperforin
6168:Activators
6048:Tear gases
6020:Polygodial
6010:PF-4840154
5995:Paclitaxel
5863:Dicentrine
5773:Bradykinin
5708:α-Sanshool
5676:Activators
5658:modulators
4783:Bestrophin
4041:SK channel
4009:BK channel
3683:γ-subunits
3656:β-subunits
3639:δ-subunits
3216:2008-10-31
1673:, May 2017
1652:, May 2017
1629:References
1511:Cannabinol
1446:Anandamide
1341:, hydroxy-
1285:receptor.
1181:Properties
1118:peripheral
337:(ortholog)
271:1|1 D
74:HomoloGene
7466:See also:
7450:TRPV3-74a
7435:SB-705498
7430:SB-366791
7380:Lanthanum
7375:HC-067047
7295:Asivatrep
7156:Rutamarin
7020:Incensole
6970:Gingerols
6939:Estradiol
6915:, others)
6897:Carvacrol
6887:Capsaicin
6781:13-oxoODE
6771:12S-HpETE
6751:5',6'-EET
6551:Rutamarin
6450:Thio-BCTC
6403:Rutamarin
6333:Coolact P
6124:HC-030031
5989:olive oil
5885:Gingerols
5698:12S-HpETE
5611:disorders
5609:see also
5392:Cytoplasm
5302:Aquaporin
4771:Anoctamin
4594:11.1/hERG
2963:(1): 23.
1565:allodynia
1523:analgesia
1391:thio-BCTC
1367:Coolact P
1312:Capsaicin
1283:capsaicin
1229:consensus
1196:capsaicin
1110:capsaicin
1025:Structure
925:NP_599013
904:NP_076985
878:NM_134252
857:NM_024080
687:Orthologs
429:spermatid
82:GeneCards
7400:NGD-8243
7385:Mavatrep
7370:GRC-6211
7339:cannabis
7329:cannabis
7319:cannabis
7309:cannabis
7290:AMG-9810
7266:Blockers
7247:Vanillin
7242:Tramadol
7206:cannabis
7184:Shogaols
7117:Piperine
6881:cannabis
6871:cannabis
6849:rosemary
6766:12S-HETE
6761:9-oxoODE
6708:Blockers
6658:PI(4,5)P
6646:Blockers
6624:PI(3,5)P
6531:Ononetin
6516:Nicotine
6464:Blockers
6440:fructose
6432:tastants
6378:Linalool
6363:Geraniol
6323:CIM-0216
6214:Blockers
6129:Nicotine
6104:A-967079
6097:Blockers
6057:cannabis
6030:Shogaols
5975:Nicotine
5941:Linalool
5880:Formalin
5842:turmeric
5838:Curcumin
5812:cinnamon
5802:cannabis
5792:cannabis
5782:cannabis
5768:ASP-7663
5726:Acrolein
5405:Connexin
4685:minK/ISK
3340:17217067
3305:17936350
3297:16382100
3258:15548706
3192:16519806
3141:18562636
3105:17703702
3097:17481392
3056:18467791
3048:16920620
2989:17705869
2930:17538622
2887:23500200
2838:21175579
2768:18354058
2723:17428469
2684:20965726
2649:10407715
2641:24472724
2601:27448228
2561:PLOS ONE
2542:20568911
2499:45406823
2456:33288697
2397:23638727
2389:16380208
2354:11433605
2346:11399291
2311:14985268
2267:25083927
2213:14757700
2151:11882888
2100:15194117
2065:18930858
1993:31488702
1936:19230823
1895:16945367
1860:34286049
1852:24664788
1813:17936350
1805:16382100
1770:35385748
1762:23963768
1669:–
1648:–
1607:See also
1585:androgen
1339:geraniol
1335:linalool
1328:Agonists
1267:nicotine
1138:receptor
1130:pressure
1094:prostate
1061:Function
1051:agonists
973:Wikidata
666:Sources:
556:membrane
367:testicle
363:prostate
7420:RN-9893
7415:RN-1734
7285:AMG-517
7251:vanilla
7220:oregano
7192:Sichuan
7170:(RTX) (
7146:Protons
7109:(e.g.,
7042:Menthol
7024:incense
6944:Eugenol
6901:oregano
6841:Camphor
6809:Allicin
6799:Sichuan
6786:20-HETE
6776:13-HODE
6619:ML2-SA1
6520:tobacco
6471:AMG-333
6444:sucrose
6436:glucose
6434:(e.g.,
6417:(e.g.,
6383:Menthol
6317:Calcium
6133:tobacco
6109:AM-0902
6038:Sichuan
5979:tobacco
5868:Lindera
5745:mustard
5731:Allicin
5716:Sichuan
5693:4,5-EET
5655:channel
5532:Innexin
5289:solutes
3183:1420318
3016:Bibcode
2980:1988789
2938:4427901
2910:Bibcode
2878:3793871
2829:3165957
2776:5997192
2592:4957794
2569:Bibcode
2534:7529306
2491:8700951
2447:7768701
2424:Bibcode
2258:4220012
2204:1574235
2159:4340358
2131:Bibcode
2108:2410787
2033:7163963
1984:7262954
1963:Bibcode
1955:Science
1671:Ensembl
1650:Ensembl
1546:ligands
1530:menthol
1410:AMG-333
1379:borneol
1375:menthol
1323:Ligands
1271:Ethanol
1246:A fiber
1216:agonist
1208:menthol
1161:neurons
1143:McKemy
1083:menthol
1043:menthol
1012:protein
799:UniProt
754:Ensembl
693:Species
672:QuickGO
312:pattern
70:2181435
38:Aliases
7360:DHEA-S
7212:Thymol
7188:ginger
7111:4α-PDD
6974:ginger
6813:garlic
6795:ginger
6756:9-HODE
6653:ML-SI3
6614:ML-SA1
6609:MK6-83
6430:Sweet
6393:PMD 38
6373:Icilin
6226:DHEA-S
6118:celery
6034:ginger
5929:celery
5920:JT-010
5910:Icilin
5889:ginger
5852:celery
5757:wasabi
5749:radish
5735:garlic
5712:ginger
3829:-gated
3827:Proton
3603:T-type
3590:R-type
3577:Q-type
3557:P-type
3544:N-type
3509:L-type
3361:(MeSH)
3338:
3328:
3303:
3295:
3256:
3190:
3180:
3139:
3103:
3095:
3075:Neuron
3054:
3046:
2987:
2977:
2936:
2928:
2902:Nature
2885:
2875:
2836:
2826:
2774:
2766:
2721:
2682:
2647:
2639:
2599:
2589:
2540:
2532:
2497:
2489:
2454:
2444:
2395:
2387:
2352:
2344:
2309:
2265:
2255:
2211:
2201:
2157:
2149:
2123:Nature
2106:
2098:
2063:
2030:
1991:
1981:
1934:
1893:
1858:
1850:
1811:
1803:
1768:
1760:
1593:siRNAs
1559:TRPM8
1427:cas: .
1389:BCTC,
1363:PMD 38
1347:icilin
1308:et al.
1306:Cliff
1279:et al.
1242:et al.
1219:pain.
1212:icilin
1200:acidic
1159:(DRG)
1145:et al.
1136:, and
1087:icilin
1047:icilin
959:search
957:PubMed
832:Q8R4D5
813:Q7Z2W7
742:171382
709:Entrez
463:BioGPS
170:2q37.1
62:606678
7350:DCDPC
7216:thyme
6952:clove
6948:basil
6905:thyme
6819:AM404
6746:2-APB
6632:SF-22
6604:EVP21
6588:TRPML
6486:DCDPC
6455:WS-12
6221:DCDPC
6072:onion
5949:thyme
5871:spp.)
5832:cumin
5763:AM404
5443:GJA10
5294:Porin
5194:TRPML
4964:HVCN1
4658:KCNIP
4513:α7-12
3417:TC 1A
3301:S2CID
3166:: 6.
3101:S2CID
3052:S2CID
2934:S2CID
2772:S2CID
2645:S2CID
2538:S2CID
2495:S2CID
2393:S2CID
2350:S2CID
2289:Brain
2155:S2CID
2104:S2CID
1856:S2CID
1809:S2CID
1766:S2CID
1597:mRNAs
1589:LNCaP
1351:WS-12
1192:TRPV1
1166:TRPV1
1114:TRPV1
1016:TRPM8
723:79054
702:Mouse
697:Human
668:Amigo
387:gonad
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:TRPM8
78:23433
45:TRPM8
22:TRPM8
7355:DHEA
7300:BCTC
7194:and
7151:RhTx
7046:mint
7034:Low
6985:Heat
6919:DHEA
6801:and
6730:TRPV
6676:TRPP
6637:SN-2
6568:TPPO
6387:mint
6328:Cold
6312:BCTC
6291:TRPM
6271:Pyr3
6159:TRPC
6040:and
5718:and
5667:TRPA
5523:GJD4
5518:GJD3
5513:GJD2
5503:GJC3
5498:GJC2
5493:GJC1
5483:GJB7
5478:GJB6
5473:GJB5
5468:GJB4
5463:GJB3
5458:GJB2
5453:GJB1
5438:GJA9
5433:GJA8
5428:GJA5
5423:GJA4
5418:GJA3
5413:GJA1
5238:TRPV
5221:TRPP
5216:TRPN
5147:TRPM
5100:TRPC
5090:TRPA
4928:CLNS
4886:CLIC
4834:CLCN
4829:CFTR
4776:ANO1
4695:MiRP
4623:12.3
4618:12.2
4613:12.1
4604:11.3
4599:11.2
4585:10.2
4580:10.1
4370:α1-6
4184:GIRK
3598:α2.3
3585:α2.1
3552:α2.2
3336:PMID
3326:ISBN
3293:PMID
3254:PMID
3188:PMID
3137:PMID
3093:PMID
3044:PMID
2985:PMID
2926:PMID
2883:PMID
2834:PMID
2764:PMID
2719:PMID
2680:PMID
2637:PMID
2597:PMID
2530:PMID
2487:PMID
2452:PMID
2385:PMID
2342:PMID
2307:PMID
2263:PMID
2237:Pain
2209:PMID
2147:PMID
2096:PMID
2061:PMID
1989:PMID
1932:PMID
1918:1788
1891:PMID
1848:PMID
1801:PMID
1758:PMID
1618:TRPM
1541:cold
1436:AMTB
1431:M8 B
1377:and
1214:(an
1210:and
1151:and
1120:and
1104:The
1085:and
1073:and
1019:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
6421:) (
5653:TRP
5287:(+
5125:4AP
5038:HCN
4571:9.3
4566:9.2
4561:9.1
4552:8.2
4547:8.1
4538:7.5
4533:7.4
4528:7.3
4523:7.2
4518:7.1
4500:6.4
4495:6.3
4490:6.2
4485:6.1
4476:5.1
4467:4.3
4462:4.2
4457:4.1
4448:3.4
4443:3.3
4438:3.2
4433:3.1
4424:2.2
4419:2.1
4410:1.8
4405:1.7
4400:1.6
4395:1.5
4390:1.4
4385:1.3
4380:1.2
4375:1.1
4271:K2P
4251:7.1
4246:6.2
4241:6.1
4236:5.1
4231:4.2
4226:4.1
4211:3.4
4206:3.3
4201:3.2
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