305:
282:
179:
204:
311:
210:
1505:
1326:
Vázquez-Higuera JL, MartĂnez-GarcĂa A, Sánchez-Juan P, RodrĂguez-RodrĂguez E, Mateo I, Pozueta A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O (2011). "Genetic variations in tau-tubulin kinase-1 are linked to
Alzheimer's disease in a Spanish case-control cohort".
1288:
Vázquez-Higuera JL, MartĂnez-GarcĂa A, Sánchez-Juan P, RodrĂguez-RodrĂguez E, Mateo I, Pozueta A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O (2011). "Genetic variations in tau-tubulin kinase-1 are linked to
Alzheimer's disease in a Spanish case-control cohort".
50:
318:
217:
1364:
Yu NN, Yu JT, Xiao JT, Zhang HW, Lu RC, Jiang H, Xing ZH, Tan L (2011). "Tau-tubulin kinase-1 gene variants are associated with
Alzheimer's disease in Han Chinese".
1245:"Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1"
845:
826:
140:
1574:
1200:
1550:
1182:
1569:
304:
1056:
1049:
281:
1452:
Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S (2014).
1403:"Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain"
1169:
1148:
1165:
203:
178:
47:
1144:
317:
216:
1243:
Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T (2008).
310:
209:
1543:
890:
128:
871:
1401:
Lund H, Cowburn RF, Gustafsson E, Strömberg K, Svensson A, Dahllund L, Malinowsky D, Sunnemark D (2013).
1536:
192:
115:
1454:"The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor"
1032:
981:
1440:
1389:
1352:
1314:
152:
1011:
985:
960:
1483:
1432:
1381:
1344:
1306:
1276:
108:
40:
1520:
1473:
1465:
1422:
1414:
1373:
1336:
1298:
1266:
1256:
397:
328:
272:
227:
148:
372:
1340:
1302:
1478:
1453:
1427:
1402:
1271:
1244:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
669:
664:
659:
654:
649:
644:
639:
623:
618:
613:
608:
603:
598:
593:
588:
1563:
575:
1444:
132:
1516:
1393:
1356:
1318:
1261:
390:
169:
1377:
156:
1205:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1187:
National Center for
Biotechnology Information, U.S. National Library of Medicine
473:
1469:
289:
186:
136:
790:
533:
411:
356:
343:
255:
242:
144:
1487:
1436:
1385:
1348:
1310:
1280:
1218:
1096:
1091:
1080:
935:
916:
1112:
902:
857:
1418:
85:
81:
77:
73:
69:
1064:
812:
1504:
1116:
775:
771:
1512:
1120:
756:
positive regulation of cyclin-dependent protein kinase activity
761:
positive regulation of cysteine-type endopeptidase activity
380:
1524:
545:
1025:
1004:
974:
953:
496:
dentate gyrus of hippocampal formation granule cell
1161:
1159:
1157:
1140:
1138:
1136:
751:positive regulation of microglial cell activation
327:
226:
16:Protein-coding gene in the species Homo sapiens
1166:GRCm38: Ensembl release 89: ENSMUSG00000015599
1544:
741:positive regulation of protein polymerization
8:
1145:GRCh38: Ensembl release 89: ENSG00000146216
746:positive regulation of astrocyte activation
1551:
1537:
786:
571:
368:
267:
164:
58:
1477:
1426:
1270:
1260:
604:protein serine/threonine kinase activity
1132:
736:negative regulation of protein binding
721:negative regulation of gene expression
716:positive regulation of gene expression
18:
332:
293:
288:
231:
190:
185:
7:
1501:
1499:
1341:10.1016/j.neurobiolaging.2009.12.021
1303:10.1016/j.neurobiolaging.2009.12.021
1219:"Entrez Gene: Tau tubulin kinase 1"
1523:. You can help Knowledge (XXG) by
1022:
1001:
971:
950:
926:
907:
881:
862:
836:
817:
726:peptidyl-threonine phosphorylation
550:
468:
406:
385:
14:
731:peptidyl-tyrosine phosphorylation
422:lateral nuclear group of thalamus
1503:
316:
309:
303:
280:
215:
208:
202:
177:
691:peptidyl-serine phosphorylation
670:perinuclear region of cytoplasm
1262:10.1523/JNEUROSCI.3417-08.2008
660:microtubule associated complex
534:More reference expression data
438:right hemisphere of cerebellum
1:
1575:Human chromosome 6 gene stubs
301:
200:
1378:10.1016/j.neulet.2011.01.011
696:substantia nigra development
119:, BDTK, tau tubulin kinase 1
1570:Genes on human chromosome 6
624:tau-protein kinase activity
1591:
1498:
1470:10.1107/S2053230X14000144
1201:"Mouse PubMed Reference:"
1183:"Human PubMed Reference:"
1095:
1090:
1086:
1079:
1063:
1044:
1029:
1008:
997:
978:
957:
946:
933:
929:
914:
910:
901:
888:
884:
869:
865:
856:
843:
839:
824:
820:
811:
796:
789:
785:
769:
574:
570:
558:
553:
544:
531:
480:
471:
446:anterior cingulate cortex
418:
409:
379:
371:
367:
350:
337:
300:
279:
270:
266:
249:
236:
199:
176:
167:
163:
126:
123:
113:
106:
101:
66:
61:
44:
39:
34:
30:
26:
21:
1119:is encoded by the TTBK1
706:regulation of cell shape
504:Rostral migratory stream
1057:Chr 17: 46.75 – 46.8 Mb
1050:Chr 6: 43.24 – 43.29 Mb
686:protein phosphorylation
599:protein kinase activity
484:superior frontal gyrus
442:superior frontal gyrus
488:primary visual cortex
295:Chromosome 17 (mouse)
1109:Tau tubulin kinase 1
589:transferase activity
508:primary motor cortex
193:Chromosome 6 (human)
62:List of PDB id codes
35:Available structures
619:tau protein binding
492:seminiferous tubule
1511:This article on a
1458:Acta Crystallogr F
891:ENSMUSG00000015599
711:learning or memory
679:Biological process
665:neuronal cell body
633:Cellular component
594:nucleotide binding
582:Molecular function
434:right frontal lobe
1532:
1531:
1419:10.1111/bpa.12001
1106:
1105:
1102:
1101:
1075:
1074:
1040:
1039:
1019:
1018:
993:
992:
968:
967:
942:
941:
923:
922:
897:
896:
878:
877:
852:
851:
833:
832:
781:
780:
566:
565:
562:
561:
540:
539:
527:
526:
500:cerebellar cortex
465:
464:
450:entorhinal cortex
430:postcentral gyrus
426:prefrontal cortex
363:
362:
262:
261:
157:TTBK1 - orthologs
97:
96:
93:
92:
45:Ortholog search:
1582:
1553:
1546:
1539:
1507:
1500:
1491:
1481:
1464:(Pt 2): 173–81.
1448:
1430:
1397:
1360:
1329:Neurobiol. Aging
1322:
1291:Neurobiol. Aging
1284:
1274:
1264:
1255:(53): 14511–21.
1229:
1228:
1226:
1225:
1215:
1209:
1208:
1197:
1191:
1190:
1179:
1173:
1163:
1152:
1142:
1088:
1087:
1059:
1052:
1035:
1023:
1014:
1002:
998:RefSeq (protein)
988:
972:
963:
951:
927:
908:
882:
863:
837:
818:
787:
572:
551:
536:
476:
474:Top expressed in
469:
414:
412:Top expressed in
407:
386:
369:
359:
346:
335:
320:
313:
307:
296:
284:
268:
258:
245:
234:
219:
212:
206:
195:
181:
165:
159:
118:
111:
88:
59:
53:
32:
31:
19:
1590:
1589:
1585:
1584:
1583:
1581:
1580:
1579:
1560:
1559:
1558:
1557:
1496:
1494:
1451:
1400:
1363:
1335:(3): 550.e5–9.
1325:
1297:(3): 550.e5–9.
1287:
1242:
1238:
1236:Further reading
1233:
1232:
1223:
1221:
1217:
1216:
1212:
1199:
1198:
1194:
1181:
1180:
1176:
1164:
1155:
1143:
1134:
1129:
1097:View/Edit Mouse
1092:View/Edit Human
1055:
1048:
1045:Location (UCSC)
1031:
1010:
984:
980:
959:
872:ENSG00000146216
765:
701:phosphorylation
674:
628:
614:kinase activity
532:
523:
518:
514:
512:cingulate gyrus
510:
506:
502:
498:
494:
490:
486:
472:
461:
456:
454:Brodmann area 9
452:
448:
444:
440:
436:
432:
428:
424:
410:
354:
341:
333:
323:
322:
321:
314:
294:
271:Gene location (
253:
240:
232:
222:
221:
220:
213:
191:
168:Gene location (
127:
114:
107:
68:
46:
17:
12:
11:
5:
1588:
1586:
1578:
1577:
1572:
1562:
1561:
1556:
1555:
1548:
1541:
1533:
1530:
1529:
1508:
1493:
1492:
1449:
1398:
1366:Neurosci. Lett
1361:
1323:
1285:
1239:
1237:
1234:
1231:
1230:
1210:
1192:
1174:
1153:
1131:
1130:
1128:
1125:
1104:
1103:
1100:
1099:
1094:
1084:
1083:
1077:
1076:
1073:
1072:
1070:
1068:
1061:
1060:
1053:
1046:
1042:
1041:
1038:
1037:
1027:
1026:
1020:
1017:
1016:
1006:
1005:
999:
995:
994:
991:
990:
976:
975:
969:
966:
965:
955:
954:
948:
944:
943:
940:
939:
931:
930:
924:
921:
920:
912:
911:
905:
899:
898:
895:
894:
886:
885:
879:
876:
875:
867:
866:
860:
854:
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850:
849:
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840:
834:
831:
830:
822:
821:
815:
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798:
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783:
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779:
778:
767:
766:
764:
763:
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753:
748:
743:
738:
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728:
723:
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713:
708:
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676:
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672:
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652:
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642:
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629:
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626:
621:
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611:
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601:
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591:
585:
583:
579:
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568:
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559:
556:
555:
548:
542:
541:
538:
537:
529:
528:
525:
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522:
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497:
493:
489:
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481:
478:
477:
466:
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460:
459:
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451:
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443:
439:
435:
431:
427:
423:
419:
416:
415:
403:
402:
394:
383:
377:
376:
373:RNA expression
365:
364:
361:
360:
352:
348:
347:
339:
336:
331:
325:
324:
315:
308:
302:
298:
297:
292:
286:
285:
277:
276:
264:
263:
260:
259:
251:
247:
246:
238:
235:
230:
224:
223:
214:
207:
201:
197:
196:
189:
183:
182:
174:
173:
161:
160:
125:
121:
120:
112:
104:
103:
99:
98:
95:
94:
91:
90:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1587:
1576:
1573:
1571:
1568:
1567:
1565:
1554:
1549:
1547:
1542:
1540:
1535:
1534:
1528:
1526:
1522:
1518:
1514:
1509:
1506:
1502:
1497:
1489:
1485:
1480:
1475:
1471:
1467:
1463:
1459:
1455:
1450:
1446:
1442:
1438:
1434:
1429:
1424:
1420:
1416:
1413:(4): 378–89.
1412:
1408:
1404:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1367:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1330:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1292:
1286:
1282:
1278:
1273:
1268:
1263:
1258:
1254:
1250:
1246:
1241:
1240:
1235:
1220:
1214:
1211:
1206:
1202:
1196:
1193:
1188:
1184:
1178:
1175:
1171:
1167:
1162:
1160:
1158:
1154:
1150:
1146:
1141:
1139:
1137:
1133:
1126:
1124:
1122:
1118:
1114:
1110:
1098:
1093:
1089:
1085:
1082:
1078:
1071:
1069:
1066:
1062:
1058:
1054:
1051:
1047:
1043:
1036:
1034:
1028:
1024:
1021:
1015:
1013:
1007:
1003:
1000:
996:
989:
987:
983:
977:
973:
970:
964:
962:
956:
952:
949:
947:RefSeq (mRNA)
945:
938:
937:
932:
928:
925:
919:
918:
913:
909:
906:
904:
900:
893:
892:
887:
883:
880:
874:
873:
868:
864:
861:
859:
855:
848:
847:
842:
838:
835:
829:
828:
823:
819:
816:
814:
810:
807:
804:
802:
799:
795:
792:
788:
784:
777:
773:
768:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
683:
681:
678:
677:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
637:
635:
632:
631:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
600:
597:
595:
592:
590:
587:
586:
584:
581:
580:
577:
576:Gene ontology
573:
569:
557:
552:
549:
547:
543:
535:
530:
519:
515:
511:
507:
503:
499:
495:
491:
487:
483:
482:
479:
475:
470:
467:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
420:
417:
413:
408:
405:
404:
401:
399:
395:
393:
392:
388:
387:
384:
382:
378:
374:
370:
366:
358:
353:
349:
345:
340:
330:
326:
319:
312:
306:
299:
291:
287:
283:
278:
274:
269:
265:
257:
252:
248:
244:
239:
229:
225:
218:
211:
205:
198:
194:
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184:
180:
175:
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166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
122:
117:
110:
105:
100:
89:
87:
83:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
1525:expanding it
1517:chromosome 6
1510:
1495:
1461:
1457:
1410:
1407:Brain Pathol
1406:
1369:
1365:
1332:
1328:
1294:
1290:
1252:
1248:
1222:. Retrieved
1213:
1204:
1195:
1186:
1177:
1108:
1107:
1033:NP_001156336
1030:
1009:
982:NM_001162864
979:
958:
934:
915:
889:
870:
844:
825:
805:
800:
396:
389:
334:17|17 C
124:External IDs
67:
1372:(1): 83–6.
1249:J. Neurosci
650:nucleoplasm
609:ATP binding
355:46,798,601
342:46,753,374
254:43,288,258
241:43,243,481
102:Identifiers
1564:Categories
1224:2017-03-23
1172:, May 2017
1151:, May 2017
1127:References
400:(ortholog)
137:HomoloGene
1515:on human
1012:NP_115927
986:NM_175351
961:NM_032538
791:Orthologs
640:cytoplasm
520:subiculum
516:spermatid
145:GeneCards
1488:24637750
1445:30089308
1437:23088643
1386:21219968
1349:20096481
1311:20096481
1281:19118186
1168:–
1147:–
1115:that in
1081:Wikidata
770:Sources:
458:amygdala
1479:3936456
1428:8029021
1394:6421145
1357:5587797
1319:5587797
1272:6671237
1170:Ensembl
1149:Ensembl
1113:protein
903:UniProt
858:Ensembl
797:Species
776:QuickGO
655:cytosol
645:nucleus
375:pattern
133:2147036
109:Aliases
1486:
1476:
1443:
1435:
1425:
1392:
1384:
1355:
1347:
1317:
1309:
1279:
1269:
1117:humans
1067:search
1065:PubMed
936:Q6PCN3
917:Q5TCY1
846:106763
813:Entrez
546:BioGPS
233:6p21.1
1519:is a
1441:S2CID
1390:S2CID
1353:S2CID
1315:S2CID
1111:is a
827:84630
806:Mouse
801:Human
772:Amigo
398:Mouse
391:Human
338:Start
273:Mouse
237:Start
170:Human
149:TTBK1
141:50342
116:TTBK1
22:TTBK1
1521:stub
1513:gene
1484:PMID
1433:PMID
1382:PMID
1345:PMID
1307:PMID
1277:PMID
1121:gene
381:Bgee
329:Band
290:Chr.
228:Band
187:Chr.
86:4NFN
82:4NFM
78:4BTM
74:4BTK
70:4BTJ
51:RCSB
48:PDBe
1474:PMC
1466:doi
1423:PMC
1415:doi
1374:doi
1370:491
1337:doi
1299:doi
1267:PMC
1257:doi
554:n/a
351:End
250:End
153:OMA
129:MGI
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