253:
230:
127:
152:
504:
259:
158:
1750:
1157:
inside the cells. Purified ZCCHC6 selectively recognizes and uridylates RNA molecules possessing short poly(A) tails (less than 25 nucleotides) in vitro. In cells depleted of ZCCHC6, the majority of mRNAs lose the signature oligo(U) tails that are characteristic of ZCCHC6 reactivity, and the
266:
165:
1273:"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
757:
738:
88:
1824:
1253:
1795:
1235:
1814:
252:
1012:
1005:
229:
1519:"Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice"
1176:
Genetic
Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.
1312:
1222:
1201:
1218:
151:
126:
1197:
1616:"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs"
68:
1094:
265:
164:
1788:
258:
157:
802:
76:
1470:"Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7)"
1819:
783:
1169:
processing. ZCCHC6 is thought to work in redundancy with ZCCHC11 to mediate the biogenesis of the let-7
1781:
1114:
140:
55:
988:
984:
980:
951:
947:
943:
917:
913:
909:
884:
876:
872:
1614:
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001).
100:
1657:
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004).
976:
955:
905:
880:
503:
1731:
1688:
1645:
1602:
1548:
1499:
1450:
1429:"Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs"
1409:
1357:
1294:
48:
1765:
1721:
1713:
1678:
1670:
1635:
1627:
1592:
1584:
1538:
1530:
1489:
1481:
1440:
1399:
1391:
1347:
1339:
1284:
1122:
345:
276:
220:
175:
59:, PAPD6, zinc finger CCHC-type containing 6, TENT3B, ZCCHC6, terminal uridylyl transferase 7
1700:
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006).
1151:
320:
96:
1726:
1701:
1543:
1518:
1494:
1469:
1404:
1379:
1352:
1327:
1683:
1658:
1640:
1615:
1597:
1572:
672:
667:
662:
657:
652:
647:
642:
637:
632:
616:
611:
606:
590:
585:
580:
575:
570:
565:
560:
555:
550:
545:
1808:
532:
80:
1761:
338:
117:
104:
1258:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1240:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1161:
In addition to mRNA degradation, uridylation is also thought to function in pre-
1445:
1428:
1395:
421:
1378:
Lim J, Ha M, Chang H, Kwon SC, Simanshu DK, Patel DJ, Kim VN (December 2014).
1165:
maturation, with some group II pre-microRNA requiring 3' mono-uridylation for
1083:
237:
134:
84:
1289:
1272:
1271:
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (December 2000).
702:
481:
359:
304:
291:
203:
190:
92:
1735:
1692:
1649:
1606:
1552:
1503:
1485:
1454:
1427:
Heo I, Ha M, Lim J, Yoon MJ, Park JE, Kwon SC, et al. (October 2012).
1413:
1361:
1298:
1052:
1047:
1717:
1343:
1170:
1162:
1036:
847:
828:
1674:
1631:
1147:
1118:
1087:
814:
769:
1588:
1534:
1517:
Ansari MY, Khan NM, Ahmad N, Green J, Novak K, Haqqi TM (April 2019).
1098:
1072:
1020:
724:
1749:
17:
1328:"Efficient RNA polyuridylation by noncanonical poly(A) polymerases"
1138:
1134:
1166:
687:
683:
1757:
1468:
Thornton JE, Chang HM, Piskounova E, Gregory RI (October 2012).
1154:
1110:
1079:
1071:), also known as "zinc finger, CCHC domain containing 6", is an
512:
72:
1091:
1313:"Entrez Gene: ZCCHC6 zinc finger, CCHC domain containing 6"
1659:"From ORFeome to biology: a functional genomics pipeline"
1380:"Uridylation by TUT4 and TUT7 marks mRNA for degradation"
1573:"DNA cloning using in vitro site-specific recombination"
328:
1769:
1158:
half-life of mRNA molecules are accordingly prolonged.
1101:
tails and is involved in mRNA and microRNA degradation
493:
969:
936:
898:
865:
1571:Hartley JL, Temple GF, Brasch MA (November 2000).
1326:Rissland OS, Mikulasova A, Norbury CJ (May 2007).
1214:
1212:
1210:
1193:
1191:
1189:
653:negative regulation of transposition, RNA-mediated
275:
174:
673:polyuridylation-dependent mRNA catabolic process
643:nuclear-transcribed mRNA poly(A) tail shortening
1133:It catalyzes the following reaction, requiring
27:Protein-coding gene in the species Homo sapiens
1219:GRCm38: Ensembl release 89: ENSMUSG00000035248
1789:
8:
1086:9. The ZCCHC6 protein mediates the terminal
1198:GRCh38: Ensembl release 89: ENSG00000083223
1150:catalyzed by ZCCHC6 takes place readily on
1796:
1782:
1373:
1371:
698:
528:
316:
215:
112:
1725:
1682:
1639:
1596:
1542:
1493:
1444:
1403:
1351:
1288:
456:fetal liver hematopoietic progenitor cell
1113:with at least six known isoforms due to
1185:
1144:UTP + RNA(n) = diphosphate + RNA(n+1)
29:
280:
241:
236:
179:
138:
133:
7:
1746:
1744:
1125:and is localized to the cytoplasm.
1768:. You can help Knowledge (XXG) by
966:
933:
895:
862:
838:
819:
793:
774:
748:
729:
498:
416:
354:
333:
25:
1075:that in humans is encoded by the
1748:
1117:. The ZCCHC6 gene encodes for a
576:RNA uridylyltransferase activity
502:
264:
257:
251:
228:
163:
156:
150:
125:
551:nucleotidyltransferase activity
1332:Molecular and Cellular Biology
1065:Terminal uridylyltransferase 7
633:histone mRNA catabolic process
513:More reference expression data
482:More reference expression data
432:basilar part of occipital bone
1:
1825:Human chromosome 9 gene stubs
1712:(Database issue): D415–D418.
1702:"The LIFEdb database in 2006"
249:
148:
1523:Arthritis & Rheumatology
1109:The ZCCHC6 gene contains 33
591:uridylyltransferase activity
1815:Genes on human chromosome 9
1841:
1743:
1446:10.1016/j.cell.2012.09.022
1396:10.1016/j.cell.2014.10.055
1254:"Mouse PubMed Reference:"
1236:"Human PubMed Reference:"
1051:
1046:
1042:
1035:
1019:
1000:
973:
940:
929:
902:
869:
858:
845:
841:
826:
822:
813:
800:
796:
781:
777:
768:
755:
751:
736:
732:
723:
708:
701:
697:
681:
531:
527:
510:
501:
492:
479:
428:
419:
398:epithelium of nasopharynx
366:
357:
327:
319:
315:
298:
285:
248:
227:
218:
214:
197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
1013:Chr 13: 59.92 – 59.97 Mb
370:tendon of biceps brachii
1006:Chr 9: 86.29 – 86.35 Mb
658:miRNA metabolic process
1706:Nucleic Acids Research
1486:10.1261/rna.034538.112
1290:10.1093/dnares/7.6.347
1173:through uridylation.
638:RNA 3'-end processing
243:Chromosome 13 (mouse)
1344:10.1128/MCB.02209-06
1115:alternative splicing
663:pre-miRNA processing
566:nucleic acid binding
546:transferase activity
141:Chromosome 9 (human)
1121:that is 171 kDa in
1756:This article on a
1718:10.1093/nar/gkj139
1675:10.1101/gr.2576704
1669:(10B): 2136–2144.
1632:10.1101/gr.GR1547R
803:ENSMUSG00000035248
668:RNA 3' uridylation
626:Biological process
600:Cellular component
539:Molecular function
440:tibiofemoral joint
378:buccal mucosa cell
1777:
1776:
1589:10.1101/gr.143000
1583:(11): 1788–1795.
1535:10.1002/art.40751
1480:(10): 1875–1885.
1338:(10): 3612–3624.
1062:
1061:
1058:
1057:
1031:
1030:
996:
995:
963:
962:
925:
924:
892:
891:
854:
853:
835:
834:
809:
808:
790:
789:
764:
763:
745:
744:
693:
692:
648:oocyte maturation
561:metal ion binding
523:
522:
519:
518:
488:
487:
475:
474:
413:
412:
402:bone marrow cells
382:periodontal fiber
311:
310:
210:
209:
16:(Redirected from
1832:
1798:
1791:
1784:
1752:
1745:
1739:
1729:
1696:
1686:
1653:
1643:
1610:
1600:
1557:
1556:
1546:
1514:
1508:
1507:
1497:
1465:
1459:
1458:
1448:
1424:
1418:
1417:
1407:
1390:(6): 1365–1376.
1375:
1366:
1365:
1355:
1323:
1317:
1316:
1309:
1303:
1302:
1292:
1268:
1262:
1261:
1250:
1244:
1243:
1232:
1226:
1216:
1205:
1195:
1123:molecular weight
1044:
1043:
1015:
1008:
991:
967:
958:
934:
930:RefSeq (protein)
920:
896:
887:
863:
839:
820:
794:
775:
749:
730:
699:
556:zinc ion binding
529:
515:
506:
499:
484:
448:genital tubercle
424:
422:Top expressed in
417:
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
255:
244:
232:
216:
206:
193:
182:
167:
160:
154:
143:
129:
113:
107:
105:TUT7 - orthologs
58:
51:
30:
21:
1840:
1839:
1835:
1834:
1833:
1831:
1830:
1829:
1805:
1804:
1803:
1802:
1742:
1699:
1663:Genome Research
1656:
1620:Genome Research
1613:
1577:Genome Research
1570:
1566:
1564:Further reading
1561:
1560:
1516:
1515:
1511:
1467:
1466:
1462:
1426:
1425:
1421:
1377:
1376:
1369:
1325:
1324:
1320:
1311:
1310:
1306:
1270:
1269:
1265:
1252:
1251:
1247:
1234:
1233:
1229:
1217:
1208:
1196:
1187:
1182:
1141:as co-factors.
1131:
1107:
1053:View/Edit Mouse
1048:View/Edit Human
1011:
1004:
1001:Location (UCSC)
987:
983:
979:
975:
954:
950:
946:
942:
916:
912:
908:
904:
883:
879:
875:
871:
784:ENSG00000083223
677:
621:
595:
581:protein binding
511:
480:
471:
466:
462:
460:renal corpuscle
458:
454:
450:
446:
442:
438:
434:
420:
409:
404:
400:
396:
392:
388:
386:Achilles tendon
384:
380:
376:
372:
358:
302:
289:
281:
271:
270:
269:
262:
242:
219:Gene location (
201:
188:
180:
170:
169:
168:
161:
139:
116:Gene location (
67:
54:
47:
28:
23:
22:
15:
12:
11:
5:
1838:
1836:
1828:
1827:
1822:
1820:Human proteins
1817:
1807:
1806:
1801:
1800:
1793:
1786:
1778:
1775:
1774:
1753:
1741:
1740:
1697:
1654:
1626:(3): 422–435.
1611:
1567:
1565:
1562:
1559:
1558:
1529:(4): 583–593.
1509:
1460:
1439:(3): 521–532.
1419:
1367:
1318:
1304:
1283:(6): 347–355.
1263:
1245:
1227:
1206:
1184:
1183:
1181:
1178:
1130:
1127:
1106:
1103:
1060:
1059:
1056:
1055:
1050:
1040:
1039:
1033:
1032:
1029:
1028:
1026:
1024:
1017:
1016:
1009:
1002:
998:
997:
994:
993:
971:
970:
964:
961:
960:
938:
937:
931:
927:
926:
923:
922:
900:
899:
893:
890:
889:
867:
866:
860:
856:
855:
852:
851:
843:
842:
836:
833:
832:
824:
823:
817:
811:
810:
807:
806:
798:
797:
791:
788:
787:
779:
778:
772:
766:
765:
762:
761:
753:
752:
746:
743:
742:
734:
733:
727:
721:
720:
715:
710:
706:
705:
695:
694:
691:
690:
679:
678:
676:
675:
670:
665:
660:
655:
650:
645:
640:
635:
629:
627:
623:
622:
620:
619:
614:
609:
603:
601:
597:
596:
594:
593:
588:
583:
578:
573:
568:
563:
558:
553:
548:
542:
540:
536:
535:
525:
524:
521:
520:
517:
516:
508:
507:
496:
490:
489:
486:
485:
477:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
426:
425:
414:
411:
410:
408:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
364:
363:
351:
350:
342:
331:
325:
324:
321:RNA expression
313:
312:
309:
308:
300:
296:
295:
287:
284:
279:
273:
272:
263:
256:
250:
246:
245:
240:
234:
233:
225:
224:
212:
211:
208:
207:
199:
195:
194:
186:
183:
178:
172:
171:
162:
155:
149:
145:
144:
137:
131:
130:
122:
121:
109:
108:
65:
61:
60:
52:
44:
43:
39:
38:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1837:
1826:
1823:
1821:
1818:
1816:
1813:
1812:
1810:
1799:
1794:
1792:
1787:
1785:
1780:
1779:
1773:
1771:
1767:
1763:
1759:
1754:
1751:
1747:
1737:
1733:
1728:
1723:
1719:
1715:
1711:
1707:
1703:
1698:
1694:
1690:
1685:
1680:
1676:
1672:
1668:
1664:
1660:
1655:
1651:
1647:
1642:
1637:
1633:
1629:
1625:
1621:
1617:
1612:
1608:
1604:
1599:
1594:
1590:
1586:
1582:
1578:
1574:
1569:
1568:
1563:
1554:
1550:
1545:
1540:
1536:
1532:
1528:
1524:
1520:
1513:
1510:
1505:
1501:
1496:
1491:
1487:
1483:
1479:
1475:
1471:
1464:
1461:
1456:
1452:
1447:
1442:
1438:
1434:
1430:
1423:
1420:
1415:
1411:
1406:
1401:
1397:
1393:
1389:
1385:
1381:
1374:
1372:
1368:
1363:
1359:
1354:
1349:
1345:
1341:
1337:
1333:
1329:
1322:
1319:
1314:
1308:
1305:
1300:
1296:
1291:
1286:
1282:
1278:
1274:
1267:
1264:
1259:
1255:
1249:
1246:
1241:
1237:
1231:
1228:
1224:
1220:
1215:
1213:
1211:
1207:
1203:
1199:
1194:
1192:
1190:
1186:
1179:
1177:
1174:
1172:
1168:
1164:
1159:
1156:
1153:
1149:
1145:
1142:
1140:
1136:
1128:
1126:
1124:
1120:
1116:
1112:
1104:
1102:
1100:
1096:
1093:
1089:
1085:
1081:
1078:
1074:
1070:
1066:
1054:
1049:
1045:
1041:
1038:
1034:
1027:
1025:
1022:
1018:
1014:
1010:
1007:
1003:
999:
992:
990:
986:
982:
978:
972:
968:
965:
959:
957:
953:
949:
945:
939:
935:
932:
928:
921:
919:
915:
911:
907:
901:
897:
894:
888:
886:
882:
878:
874:
868:
864:
861:
859:RefSeq (mRNA)
857:
850:
849:
844:
840:
837:
831:
830:
825:
821:
818:
816:
812:
805:
804:
799:
795:
792:
786:
785:
780:
776:
773:
771:
767:
760:
759:
754:
750:
747:
741:
740:
735:
731:
728:
726:
722:
719:
716:
714:
711:
707:
704:
700:
696:
689:
685:
680:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
618:
615:
613:
610:
608:
605:
604:
602:
599:
598:
592:
589:
587:
586:miRNA binding
584:
582:
579:
577:
574:
572:
569:
567:
564:
562:
559:
557:
554:
552:
549:
547:
544:
543:
541:
538:
537:
534:
533:Gene ontology
530:
526:
514:
509:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
405:
401:
397:
393:
390:skin of thigh
389:
385:
381:
377:
373:
369:
368:
365:
361:
356:
353:
352:
349:
347:
343:
341:
340:
336:
335:
332:
330:
326:
322:
318:
314:
306:
301:
297:
293:
288:
282:13|13 B2
278:
274:
267:
260:
254:
247:
239:
235:
231:
226:
222:
217:
213:
205:
200:
196:
192:
187:
177:
173:
166:
159:
153:
146:
142:
136:
132:
128:
123:
119:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
70:
62:
57:
50:
45:
40:
36:
31:
19:
1770:expanding it
1762:chromosome 9
1755:
1709:
1705:
1666:
1662:
1623:
1619:
1580:
1576:
1526:
1522:
1512:
1477:
1473:
1463:
1436:
1432:
1422:
1387:
1383:
1335:
1331:
1321:
1307:
1280:
1277:DNA Research
1276:
1266:
1257:
1248:
1239:
1230:
1175:
1160:
1152:deadenylated
1146:
1143:
1132:
1108:
1076:
1068:
1064:
1063:
989:NP_001360893
985:NP_001360892
981:NP_001360891
974:
952:NP_001317647
948:NP_001172003
944:NP_001171988
941:
918:NM_001373964
914:NM_001373963
910:NM_001373962
903:
885:NM_001330718
877:NM_001185074
873:NM_001185059
870:
846:
827:
801:
782:
756:
737:
717:
712:
344:
337:
64:External IDs
1148:Uridylation
1097:with short
1095:transcripts
1088:uridylation
1082:located on
612:nucleoplasm
571:RNA binding
444:bone marrow
436:granulocyte
406:oral cavity
303:59,970,961
290:59,919,375
202:86,354,454
189:86,287,733
42:Identifiers
1809:Categories
1225:, May 2017
1204:, May 2017
1180:References
1084:chromosome
348:(ortholog)
85:HomoloGene
1760:on human
1105:Structure
977:NP_705766
956:NP_078893
906:NM_153538
881:NM_024617
703:Orthologs
607:cytoplasm
93:GeneCards
1736:16381901
1693:15489336
1650:11230166
1607:11076863
1553:30302948
1504:22898984
1455:23063654
1414:25480299
1362:17353264
1299:11214970
1221:–
1200:–
1171:microRNA
1163:microRNA
1129:Function
1037:Wikidata
682:Sources:
394:monocyte
1727:1347501
1544:6438766
1495:3446710
1405:4720960
1353:1899984
1223:Ensembl
1202:Ensembl
1119:protein
815:UniProt
770:Ensembl
709:Species
688:QuickGO
617:cytosol
452:jejunum
323:pattern
181:9q21.33
81:2387179
49:Aliases
1734:
1724:
1691:
1684:528930
1681:
1648:
1641:311072
1638:
1605:
1598:310948
1595:
1551:
1541:
1502:
1492:
1453:
1412:
1402:
1360:
1350:
1297:
1099:poly-A
1077:ZCCHC6
1073:enzyme
1023:search
1021:PubMed
848:Q5BLK4
829:Q5VYS8
758:214290
725:Entrez
494:BioGPS
73:613467
1764:is a
1167:Dicer
1155:mRNAs
1111:exons
739:79670
718:Mouse
713:Human
684:Amigo
468:blood
464:ileum
374:blood
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
89:51941
1766:stub
1758:gene
1732:PMID
1689:PMID
1646:PMID
1603:PMID
1549:PMID
1500:PMID
1451:PMID
1433:Cell
1410:PMID
1384:Cell
1358:PMID
1295:PMID
1139:Mn2+
1137:and
1135:Mg2+
1080:gene
1069:TUT7
329:Bgee
277:Band
238:Chr.
176:Band
135:Chr.
97:TUT7
69:OMIM
56:TUT7
33:TUT7
18:TUT7
1722:PMC
1714:doi
1679:PMC
1671:doi
1636:PMC
1628:doi
1593:PMC
1585:doi
1539:PMC
1531:doi
1490:PMC
1482:doi
1474:RNA
1441:doi
1437:151
1400:PMC
1392:doi
1388:159
1348:PMC
1340:doi
1285:doi
1092:RNA
1090:of
299:End
198:End
101:OMA
77:MGI
1811::
1730:.
1720:.
1710:34
1708:.
1704:.
1687:.
1677:.
1667:14
1665:.
1661:.
1644:.
1634:.
1624:11
1622:.
1618:.
1601:.
1591:.
1581:10
1579:.
1575:.
1547:.
1537:.
1527:71
1525:.
1521:.
1498:.
1488:.
1478:18
1476:.
1472:.
1449:.
1435:.
1431:.
1408:.
1398:.
1386:.
1382:.
1370:^
1356:.
1346:.
1336:27
1334:.
1330:.
1293:.
1279:.
1275:.
1256:.
1238:.
1209:^
1188:^
686:/
305:bp
292:bp
204:bp
191:bp
99:;
95::
91:;
87::
83:;
79::
75:;
71::
1797:e
1790:t
1783:v
1772:.
1738:.
1716::
1695:.
1673::
1652:.
1630::
1609:.
1587::
1555:.
1533::
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1484::
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1394::
1364:.
1342::
1315:.
1301:.
1287::
1281:7
1260:.
1242:.
1067:(
223:)
120:)
103::
20:)
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