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Talaromycosis

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In those without HIV infection, the lungs, liver, and mouth are usually affected, with systemic infection rarely occurring. The skin lesions are also often smooth. The disease tends to present differently in those with HIV infection; they are more likely to experience widespread infection. Their skin
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Talaromycosis is endemic exclusively to southeast Asia (including southern China and eastern India), and particularly in young farmers. The exact number of people in the world affected is not known. Men are affected more than women. The first natural human case of talaromycosis was reported in 1973
578:, the number of cases in those without HIV began to rise in some endemic areas since the mid-1990s, likely due to improved diagnosis and an increase in other conditions that reduce immunity. The disease has been found to be more common in young farmers. Men are affected more than women. 432:
the organism from the environment. However, the exact source of infection is not known. The infection is not spread person-to-person. In Thailand, talaromycosis is more common during the rainy season; rain may promote the proliferation of the fungus in the environment.
1130: 1115: 486:. Intracellular and extracellular forms are oval and have a characteristic transverse septum. In culture, colonies are powdery green and produce red pigment; however, cultures are negative in a significant number of cases. 1018:
Thu, Nguyen T. M.; Chan, Jasper F. W.; Ly, Vo Trieu; Ngo, Hoa T.; Hien, Ha T. A.; Lan, Nguyen P. H.; Chau, Nguyen V. V.; Cai, Jian-Piao; Woo, Patrick C. Y.; Day, Jeremy N.; van Doorn, Rogier (21 June 2020).
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Chastain, Daniel B.; Henao-Martínez, Andrés F.; Franco-Paredes, Carlos (22 August 2017). "Opportunistic Invasive Mycoses in AIDS: Cryptococcosis, Histoplasmosis, Coccidiodomycosis, and Talaromycosis".
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are typically the ones to contract this infection. It generally does not affect healthy people and does not spread from person to person. Diagnosis is usually made by identification of the fungus from
960:"Talaromycosis (Penicilliosis) Due to Talaromyces (Penicillium) marneffei: Insights into the Clinical Trends of a Major Fungal Disease 60 Years After the Discovery of the Pathogen" 609:
An antigen assay has been developed to detect a key virulence factor Mp1p that has been shown to have a high specificity for Talaromyces marneffei.
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as a new species with disease potential. The first natural human case of talaromycosis was reported in 1973 in an American minister with
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Ning, Chuanyi; Lai, Jingzhen; Wei, Wudi; Zhou, Bo; Huang, Jiegang; Jiang, Junjun; Liang, Bingyu; Liao, Yanyan; Zang, Ning (2018).
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the fungus from the environment, though the environmental source of the organism is not known. People already suffering from a
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The exact number of people in the world affected is not known. Once considered rare, its occurrence increased due to
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such as sputum, blood, skin scrapings, lymph node, and bone marrow, by which time the disease is in the late-stage.
344:. The head and neck are most often affected. Other features include: fever, general discomfort, weight loss, cough, 1409: 1351: 2139: 2349: 2146: 1708: 1388: 575: 2227: 2190: 2132: 2057: 2032: 2026: 1823: 1515: 1437: 555: 2255: 2186: 1925: 1914: 1843: 1833: 1818: 1724: 1689: 1661: 1626: 1598: 1416: 567: 135: 1998: 1746: 1402: 1177: 516: 369: 306: 238: 86: 594: 242:, which is found in soil and decomposing organic matter. The infection is thought to be contracted by 1776: 2172: 2162: 1976: 1873: 1868: 1732: 1655: 1594: 775: 598: 329: 396:
Talaromycosis rarely affects healthy people and generally occurs in people who are already sick and
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With treatment, less than 25% of those affected die. Without treatment, more than 75% will die.
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Non-specific laboratory findings may show evidence of the fungus invading tissue, such as
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lesions however, are usually dented in the centre and can appear similar to
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There may be no symptoms, or talaromycosis may present with small painless
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Talaromycosis may be prevented in people at high risk, using the
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Talaromycosis may be prevented in people at high risk, using the
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may reveal shadows in the lungs. The disease can look similar to
1242: 730:"Talaromycosis (formerly Penicilliosis) | Fungal Diseases | CDC" 1166: 574:. While incidence in those with HIV began to decrease due to 958:
Cao, Cunwei; Xi, Liyan; Chaturvedi, Vishnu (December 2019).
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in Vietnam in 1956. Three years later, it was described by
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genus are also known to cause the disease in rare cases.
644:"ICD-11 - ICD-11 for Mortality and Morbidity Statistics" 221:
of the face and neck, as well as an associated fever,
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Diagnosis relies on identifying 14: 492:may reveal shadows in the lungs. 1864:Congenital cutaneous candidiasis 1643:Primary pulmonary histoplasmosis 1638:Primary cutaneous histoplasmosis 1345:Proximal subungual onychomycosis 554:to become the third most common 500:The disease can look similar to 384:, however, other species of the 1969:Primary cutaneous aspergillosis 1610:Disseminated coccidioidomycosis 1335:White superficial onychomycosis 1340:Distal subungual onychomycosis 876:. Elsevier. pp. 420–421. 736:. 3 March 2021. Archived from 1: 1684:Paracoccidioides brasiliensis 601:who lived in Southeast Asia. 354:liver swelling (hepatomegaly) 348:, diarrhoea, abdominal pain, 332:who lived in Southeast Asia. 328:in an American minister with 2232:Encephalitozoon intestinalis 1725:South American blastomycosis 1720:North American blastomycosis 1325:Tinea pedis (athlete's foot) 1025:Clinical Infectious Diseases 789:10.1371/journal.pone.0195569 364:. There may be no symptoms. 217:that presents with painless 2304:Granuloma gluteale infantum 1330:Tinea unguium/onychomycosis 870:"28. The dimorphic mycoses" 457:are found in half of case. 416:, old age, malnutrition or 266:, old age, malnutrition or 236:It is caused by the fungus 2366: 1352:Tinea corporis gladiatorum 976:10.1007/s11046-019-00410-2 589:was first isolated from a 468:due to liver involvement. 441:There is no accurate fast 250:due to conditions such as 2140:Syncephalastrum racemosum 914:10.1007/s11908-017-0592-7 398:unable to fight infection 225:, and enlargement of the 2147:Apophysomyces variabilis 1709:Blastomyces dermatitidis 1424:Trichophyton schoenleini 1389:Epidermophyton floccosum 576:antiretroviral treatment 522:, and is treatable with 312:, and is treatable with 196:Often fatal if untreated 2228:Enterocytozoon bieneusi 2191:Conidiobolus incongruus 2133:Lichtheimia corymbifera 2058:Cryptococcus neoformans 2027:Pseudallescheria boydii 1516:Malassezia folliculitis 1438:Trichophyton verrucosum 556:opportunistic infection 110:, old age, malnutrition 2345:Animal fungal diseases 2256:Rhinosporidium seeberi 2187:Conidiobolus coronatus 1926:Pneumocystis pneumonia 1915:Pneumocystis jirovecii 1844:Candidal onychomycosis 1834:Antibiotic candidiasis 1690:Paracoccidioidomycosis 1662:African histoplasmosis 1627:Histoplasma capsulatum 1599:Coccidioides posadasii 1417:Trichophyton tonsurans 868:Proia, Laurie (2020). 558:(after extrapulmonary 496:Differential diagnosis 466:elevated transaminases 248:weakened immune system 136:Differential diagnosis 1999:Phialophora verrucosa 1829:Chronic mucocutaneous 1747:Talaromyces marneffei 1403:Microsporum audouinii 517:antifungal medication 447:Talaromyces marneffei 414:long-term steroid use 370:molluscum contagiosum 307:antifungal medication 264:long-term steroid use 239:Talaromyces marneffei 87:Talaromyces marneffei 31:Penicillium marneffei 2173:Basidiobolus ranarum 2163:Entomophthoramycosis 1977:Exophiala jeanselmei 1874:Systemic candidiasis 1869:Perianal candidiasis 1733:Sporothrix schenckii 1656:Histoplasma duboisii 1595:Coccidioides immitis 1085:. Elsevier/Saunders. 346:difficulty breathing 2285:Fungal folliculitis 2013:Geotrichum candidum 2005:Chromoblastomycosis 1849:Candidal paronychia 1839:Candidal intertrigo 1431:Trichophyton rubrum 1038:10.1093/cid/ciaa826 780:2018PLoSO..1395569N 51:Infectious diseases 2197:Conidiobolomycosis 2179:Basidiobolomycosis 1995:Fonsecaea compacta 1991:Fonsecaea pedrosoi 1859:Diaper candidiasis 1605:Coccidioidomycosis 451:clinical specimens 418:autoimmune disease 336:Signs and symptoms 272:clinical specimens 268:autoimmune disease 104:long-term steroids 71:large lymph glands 2332: 2331: 2324:Phaeohyphomycosis 2309:Hyalohyphomycosis 2241: 2240: 2207: 2206: 2043: 2042: 1787: 1786: 1540: 1539: 1505:Malassezia furfur 1490: 1489: 1460:Hortaea werneckii 1447: 1446: 1396:Microsporum canis 1160: 1159: 883:978-0-323-56866-1 599:Hodgkin's disease 595:Gabriel Segretain 474:of skin lesions, 449:in cultures from 330:Hodgkin's disease 278:of skin lesions, 208: 207: 116:Diagnostic method 77:. Sometimes none. 16:Medical condition 2357: 2262:Rhinosporidiosis 2218:Microsporidiosis 2158:Entomophthorales 2100: 2077:Trichosporonosis 1803:Candida albicans 1777:Adiaspiromycosis 1582: 1571: 1562: 1511:Tinea versicolor 1272: 1257: 1248: 1194:Fungal infection 1187: 1180: 1173: 1164: 1099: 1087: 1086: 1078: 1069: 1068: 1058: 1040: 1031:(2): e330–e336. 1015: 1004: 1003: 955: 942: 941: 897: 888: 887: 865: 820: 819: 809: 791: 759: 750: 749: 747: 745: 726: 659: 658: 656: 654: 640: 443:serological test 410:organ transplant 260:organ transplant 215:fungal infection 108:organ transplant 19: 2365: 2364: 2360: 2359: 2358: 2356: 2355: 2354: 2350:Fungal diseases 2335: 2334: 2333: 2328: 2268: 2237: 2215: 2203: 2160: 2152: 2119:Rhizopus oryzae 2106: 2091: 2083: 2039: 1932: 1783: 1696: 1577: 1554: 1549: 1536: 1486: 1474:Piedraia hortae 1443: 1376: 1367:Tinea incognito 1362:Tinea imbricata 1266:Dermatophytosis 1263: 1237: 1228: 1219: 1213: 1209: 1200: 1191: 1161: 1156: 1155: 1110: 1096: 1091: 1090: 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1269: 1254: 1245: 1216:dermatomycosis 1202: 1201: 1198:mesomycetozoea 1192: 1190: 1189: 1182: 1175: 1167: 1158: 1157: 1154: 1153: 1142: 1127: 1111: 1106: 1105: 1103: 1102:Classification 1095: 1094:External links 1092: 1089: 1088: 1070: 1005: 970:(6): 709–720. 964:Mycopathologia 943: 889: 882: 821: 751: 660: 617: 616: 614: 611: 606: 603: 583: 580: 572:Southeast Asia 564:cryptococcosis 547: 544: 539: 536: 524:amphotericin B 512: 509: 506:histoplasmosis 497: 494: 484:histopathology 455:Fungi in blood 438: 435: 425: 422: 393: 390: 377: 374: 337: 334: 314:amphotericin B 300:histoplasmosis 288:histopathology 206: 205: 204:unknown M>F 202: 198: 197: 194: 188: 187: 177:Amphotericin B 174: 168: 167: 162: 158: 157: 152: 148: 147: 145:histoplasmosis 138: 132: 131: 118: 112: 111: 97: 91: 90: 83: 79: 78: 60: 54: 53: 48: 42: 41: 28: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 2362: 2351: 2348: 2346: 2343: 2342: 2340: 2325: 2322: 2320: 2319:Keratomycosis 2317: 2315: 2312: 2310: 2307: 2305: 2302: 2298: 2295: 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1496:Basidiomycota 1493: 1481: 1478: 1477: 1476: 1475: 1471: 1467: 1464: 1463: 1462: 1461: 1457: 1456: 1454: 1450: 1440: 1439: 1435: 1433: 1432: 1428: 1426: 1425: 1421: 1419: 1418: 1414: 1412: 1411: 1407: 1405: 1404: 1400: 1398: 1397: 1393: 1391: 1390: 1386: 1385: 1383: 1379: 1373: 1370: 1368: 1365: 1363: 1360: 1358: 1355: 1353: 1350: 1346: 1343: 1341: 1338: 1336: 1333: 1332: 1331: 1328: 1326: 1323: 1321: 1318: 1316: 1313: 1309: 1306: 1304: 1301: 1300: 1299: 1296: 1292: 1289: 1288: 1287: 1286:tinea capitis 1283: 1280: 1279: 1277: 1273: 1270: 1267: 1262: 1258: 1255: 1253: 1249: 1246: 1244: 1240: 1235: 1231: 1226: 1222: 1217: 1212: 1207: 1203: 1199: 1195: 1188: 1183: 1181: 1176: 1174: 1169: 1168: 1165: 1152: 1148: 1147: 1143: 1141: 1137: 1136: 1132: 1128: 1126: 1122: 1121: 1117: 1113: 1112: 1109: 1104: 1100: 1093: 1084: 1077: 1075: 1071: 1066: 1062: 1057: 1052: 1048: 1044: 1039: 1034: 1030: 1026: 1022: 1014: 1012: 1010: 1006: 1001: 997: 993: 989: 985: 981: 977: 973: 969: 965: 961: 954: 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261: 257: 253: 249: 245: 241: 240: 234: 232: 228: 224: 220: 216: 212: 211:Talaromycosis 203: 199: 195: 193: 189: 186: 182: 178: 175: 173: 169: 166: 163: 159: 156: 153: 149: 146: 142: 139: 137: 133: 130: 126: 122: 119: 117: 113: 109: 105: 101: 98: 96: 92: 89: 88: 84: 80: 76: 72: 68: 64: 61: 59: 55: 52: 49: 47: 43: 40: 36: 35:penicilliosis 32: 29: 25: 22:Talaromycosis 20: 2289: 2254: 2226: 2185: 2171: 2145: 2138: 2131: 2124: 2117: 2109:Mucormycosis 2070:Trichosporon 2068: 2056: 2025: 2019:Geotrichosis 2011: 1989: 1975: 1959:Aspergilloma 1946: 1913: 1906: 1899: 1892: 1885: 1824:Vulvovaginal 1801: 1769: 1752: 1745: 1731: 1707: 1682: 1668: 1654: 1625: 1593: 1578:(yeast+mold) 1546:Subcutaneous 1530:White piedra 1524:Trichosporon 1522: 1503: 1480:Black piedra 1472: 1458: 1436: 1429: 1422: 1415: 1408: 1401: 1394: 1387: 1357:Tinea faciei 1320:Tinea manuum 1315:Tinea cruris 1282:Tinea barbae 1261:Dermatophyte 1144: 1129: 1114: 1082: 1028: 1024: 967: 963: 905: 901: 873: 771: 767: 742:. 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Retrieved 647: 608: 587:T. marneffei 586: 585: 560:tuberculosis 549: 546:Epidemiology 541: 532:voriconazole 528:itraconazole 526:followed by 520:itraconazole 514: 502:tuberculosis 499: 488: 470: 459: 446: 440: 430:breathing in 427: 395: 392:Risk factors 385: 382:T. marneffei 381: 379: 366: 342:skin lesions 339: 326: 322:voriconazole 318:itraconazole 316:followed by 310:itraconazole 304: 296:tuberculosis 237: 235: 227:lymph glands 219:skin lesions 210: 209: 185:voriconazole 181:itraconazole 179:followed by 155:Itraconazole 141:Tuberculosis 95:Risk factors 85: 63:skin lesions 39:penicillosis 38: 34: 30: 2094:Zygomycosis 1948:Aspergillus 1894:C. glabrata 1809:Candidiasis 1765:Emmonsiosis 1676:Lobomycosis 1466:Tinea nigra 1381:By organism 1275:By location 1206:Superficial 734:www.cdc.gov 648:icd.who.int 480:bone marrow 476:lymph nodes 386:Talaromyces 284:bone marrow 280:lymph nodes 165:Antifungals 123:, culture, 75:large liver 27:Other names 2339:Categories 2314:Otomycosis 2297:Fusariosis 2089:Zygomycota 1983:Eumycetoma 1819:Esophageal 1586:Onygenales 1566:Ascomycota 1252:Ascomycota 1146:DiseasesDB 908:(10): 36. 613:References 591:bamboo rat 172:Medication 151:Prevention 121:Microscopy 2273:Ungrouped 2104:Mucorales 1575:Dimorphic 1239:endothrix 1211:cutaneous 1047:1537-6591 1000:208744711 984:1573-0832 922:1523-3847 798:1932-6203 511:Treatment 437:Diagnosis 424:Mechanism 201:Frequency 192:Prognosis 161:Treatment 65:, fever, 46:Specialty 2291:Fusarium 1887:C. auris 1854:Candidid 1551:systemic 1303:Ringworm 1234:exothrix 1065:32564074 992:31811603 938:26045334 930:28831671 816:29621346 768:PLOS ONE 605:Research 570:area of 552:HIV/AIDS 538:Outcomes 472:Biopsies 402:HIV/AIDS 400:such as 276:Biopsies 252:HIV/AIDS 244:inhaling 100:HIV/AIDS 58:Symptoms 1056:8282318 807:5886574 776:Bibcode 744:12 July 653:11 July 582:History 568:endemic 223:anaemia 67:anaemia 1291:Kerion 1230:Piedra 1063:  1053:  1045:  998:  990:  982:  936:  928:  920:  880:  814:  804:  796:  478:, and 406:cancer 362:anemia 360:, and 282:, and 256:cancer 125:biopsy 82:Causes 1940:-like 1795:-like 1793:Yeast 1701:Other 1452:Other 1372:Favus 1221:Tinea 1140:117.3 1125:B48.4 996:S2CID 934:S2CID 376:Cause 231:liver 213:is a 1938:Mold 1814:Oral 1555:and 1243:hair 1241:) = 1225:skin 1196:and 1151:9802 1135:9-CM 1061:PMID 1043:ISSN 988:PMID 980:ISSN 926:PMID 918:ISSN 878:ISBN 812:PMID 794:ISSN 746:2021 655:2021 562:and 504:and 298:and 229:and 2073:spp 1208:and 1131:ICD 1116:ICD 1051:PMC 1033:doi 972:doi 968:184 910:doi 802:PMC 784:doi 530:or 320:or 183:or 37:or 2341:: 1617:. 1223:= 1218:): 1149:: 1138:: 1123:: 1120:10 1073:^ 1059:. 1049:. 1041:. 1029:73 1027:. 1023:. 1008:^ 994:. 986:. 978:. 966:. 962:. 946:^ 932:. 924:. 916:. 906:19 904:. 892:^ 824:^ 810:. 800:. 792:. 782:. 772:13 770:. 766:. 754:^ 732:. 663:^ 646:. 621:^ 534:. 420:. 412:, 408:, 404:, 372:. 356:, 352:, 302:. 290:. 262:, 258:, 254:, 233:. 143:, 127:, 106:, 102:, 73:, 69:, 33:, 2230:/ 2220:) 2216:( 2189:/ 2165:) 2161:( 2111:) 2107:( 2096:) 2092:( 1997:/ 1993:/ 1597:/ 1553:, 1548:, 1284:/ 1268:) 1264:( 1236:/ 1232:( 1227:; 1214:( 1186:e 1179:t 1172:v 1133:- 1118:- 1108:D 1067:. 1035:: 1002:. 974:: 940:. 912:: 886:. 818:. 786:: 778:: 748:. 657:.

Index

Specialty
Infectious diseases
Symptoms
skin lesions
anaemia
large lymph glands
large liver
Talaromyces marneffei
Risk factors
HIV/AIDS
long-term steroids
organ transplant
Diagnostic method
Microscopy
biopsy
medical imaging
Differential diagnosis
Tuberculosis
histoplasmosis
Itraconazole
Antifungals
Medication
Amphotericin B
itraconazole
voriconazole
Prognosis
fungal infection
skin lesions
anaemia
lymph glands

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