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699:"Anaphylaxis occurs at a rate of 1:200 in first-time use, but serology (antibodies against aprotinin) is not advocated to prevent anaphylaxis on reexposure due to metholodological problems." From this sentence, it appears that the writer means that serology is an antibody, and that it is not advocated to prevent anaphylaxis (although I don't think that is what you mean)... Knowledge should be written for the general population, not medical professionals. Even if the audience were medical professionals, the sentence is still awkward.
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821:, I believe that there are substantial sources of information involving the litigation surrounding this drug. The Judicial Panel on Multidistrict Litigation heard arguments in March of 2008. This hearing took place after Bayer requested that the Federal Court cases be consolidated in front of one judge. see:
829:. On the front line reviewing the millions of pages of documents to be produced by Bayer is a court appointed plaintiffs steering committee in MDL. All cases filed in Federal Court will be tranferred to Florida where they will be part of this consolidated effort to get to the bottom of what occurred. (
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I concede that probably more total people care about the drug than about the actual protein, so the merge and title are OK, given the redirect. But since BPTI is also very important to the history of scientific research on protein structure, I've added more facts and citations and an image, and
725:
The drug does not have a "murky history". What has gone wrong is that the FDA and Bayer disagree on whether the safety data has been underreported. The
Fergusson paper does document some important points, but whether that concerns aprotinin alone or whether this is something that permeates all
726:
clinical research has yet to be established. I'd personally rather use a drug that has been tested in larger numbers of patients, even if there has been some duplication. Yet, this should preferentially be in larger trials to make the data generalisable. Some chemotherapy regimens are used
849:
It looks like there is a parallel page called BPTI on the same protein. These should of course be merged. But what should the article be called. Personally I'm used to calling this protein BPTI, but I guess the more clinically interested would object to this... Thoughts anyone...?
782:
The gist seems to be a reiteration of the FDA's poor handling of postmartketing surveillance, an issue already exposed by the rofecoxib case. While we should mention the fact that these clashes have taken place, the NEJM articles do not provide new data on the safety of trasylol.
713:
Apart from the way this article has ended up in legal circles, it needs the two articles from todays NEJM to bring it up to date. This drug has a murky history, and I would lso include Dean
Fergusson's paper in Clinical Trials (2005; 2: 218–232) on the ethical issues.
864:(prefer spelled out names), but well, if BPTI is the name the community knows this drug under, that's fine with me. Another guideline says the INN-name? But as I said, pure policy. I know not a lot about these things. I'll see where it ends up. --
573:
What is your opinion on this? Is there a nephrology expert (I thought there was on the MD page) who could weigh in on this? While I abhor attempts to use
Knowledge for advertising, I wonder Monheit's statement about safety was
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647:; Relevant papers regarding that discovery: "G. Wagner and K. Wuthrich. J. Mol. Biol. 155 (1982), pp. 347–366." and "C. Stassinopoulou, G. Wagner and K. Wuthrich. Eur. J. Biochem. 145 (1984), pp. 423–430."
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I need the title of the 1928 German paper, in German preferable. I'm also looking for the earliest mention of the amino acid sequence, which I've presently inserted without a cite.
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Is this an accurate statement? IT seems shorter and clearer for the statement to be at the beginning of the paragraph. The way it is now is muddy, and rather cumbersome.
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https://web.archive.org/web/20140201214751/http://www.nordicpharmagroup.com/art-4-4-38-the-nordic-group-acquires-rights-to-trasylol-from-bayer-healthcare.html
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We have not heard the end of this. Dr
Mangano has suggested that the research community has been lax in not following up renal side effects reported in 1993
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877:. I have completed the merge and done some other tidying up. I will need to read the NEJM articles to see whether they are clinical or political papers.
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905:, out this week, both showing increased mortality and renal impairment. Perhaps it is safe to say that aprotinin's days are well and truly numbered.
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What about the recent claim that "up to 22,000" preventable deaths have occurred due to
Trasylol? At least it caused Bayer stocks to plummet.
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When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
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http://www.nordicpharmagroup.com/art-4-4-38-the-nordic-group-acquires-rights-to-trasylol-from-bayer-healthcare.html
803:
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to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
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William Hiatt on discrepancies between observational studies and Bayer's handling of the 67,000 patient study
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If you have discovered URLs which were erroneously considered dead by the bot, you can report them with
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826:
825:. Thereafter, on April 7, 2008, the granted MDL status to the litigation surrounding this drug. See:
588:
39:
1014:. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit
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There seems to be some information regarding the determination of aprotinin's structure by NMR here:
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on
Knowledge. If you would like to participate, please visit the project page, where you can join
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on
Knowledge. If you would like to participate, please visit the project page, where you can join
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on
Knowledge. If you would like to participate, please visit the project page, where you can join
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The name is used interchangeably, but aprotinin and trasylol (each 2,000,000) both outgoogle BPTI
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before doing mass systematic removals. This message is updated dynamically through the template
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This is a confusing sentence. Perhaps, JFW, you could rewrite to be a bit more comprehensible?
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https://web.archive.org/web/20110717091728/http://www.trasylol.com/Trasylol_11_05_07.pdf
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607:, led by Dennis T. Mangano, advises replacing Aprotinin by other, safer generic drugs."
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If you found an error with any archives or the URLs themselves, you can fix them with
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rearranged the article somewhat to end with a section on BPTI as a protein.
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for additional information. I made the following changes:
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patients with
Hodgkin's lymphoma are in clinical trials).
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patients as well as the number of patients needing kidney
188:. To participate, help improve this article or visit the
1011:
676:. Is Trasylol actually still extracted from cow lung?
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was the trial that started its use in major surgery.
385:, a collaborative effort to improve the coverage of
276:, a collaborative effort to improve the coverage of
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WikiProject Molecular and Cellular Biology articles
1060:using the archive tool instructions below. Editors
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clinical publications about evidence-based medicine
310:This article has not yet received a rating on the
672:reports production of a correctly folded form by
475:Knowledge:Identifying reliable sources (medicine)
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182:, which aims to improve Knowledge's coverage of
860:From a pure policy view, BPTI would be against
1046:This message was posted before February 2018.
1183:Unknown-importance Molecular Biology articles
1028:http://www.trasylol.com/Trasylol_11_05_07.pdf
760:Jeffrey Drazen on Mangaro's data and the FDA.
8:
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730:in trial context (e.g. in The Netherlands
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579:"Aprotinin doubles a patient's risk of
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290:Knowledge:WikiProject Molecular Biology
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928:- and another one. Aprotinin is dead.
817:As discussed on my usertalk page with
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38:It is of interest to the following
1213:Mid-importance Physiology articles
1178:B-Class Molecular Biology articles
99:Knowledge:WikiProject Pharmacology
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1173:Mid-importance chemicals articles
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93:and see a list of open tasks.
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1120:https://www.aprotinin.co.uk/
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1208:B-Class Physiology articles
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1003:Hello fellow Wikipedians,
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427:.
314:.
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127:.
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