Talk:Fluoxetine/Archive 2

888:

has by very nature a short attention span, and is highly active. Instead of telling the parents to control their children like they should, the doctor will rescribe them prozac. You see, in a world where physical punishment is frowned upon ( I do not mean abuse! I would say a spanking is in order. I got spanked quite often when I messed up a child, and I turned out just fine, and there are millions like me)the kid is left with very little tangible consequences. He gets sent to his/her room, where they will most likely play video games, or call their friends to tell them what a drag their parents are. In retaliation, the parents send their children to a doc who will 9 out of 10 times, perscribe them prozac. Parents at that point no longer control their childrens erratic behaviour, but the drug does. Now fast forward to 10 yeard later. The child is sick of taking med's and wants to try life without them. I hate to say it people, but an addiction is an addiction. Every major depression they would have felt growing up was masked by the prozac, so they never really learned how to deal with the harshness of everyday life. Many of them will turn to other drugs to ease this feeling. This is wrong, and only happens because the parents failed to control their children. This in turn creates an even bigger problem when the child grows up, because they have no way to control their emotions. On the flip side, if someone is suffering from depression so bad, or they find that they cannot concentrate on the job at hand at all, then you call the doc, and should be given a drug like prozac. What it all comes down to, is people inability to cope with something. We all have problems coping from time to time, and from time to time, would be justified in something to take the edge off. But to constantly use it, even when it is not necessary, will only cloud things up worse. A lack of discipline is also a major factor. I welcome arguments to my point, and will check up regularly :-)

1593:

stereotypes based on the belief that women have already gained gender equality within western society. Sarafem and PMDD are thus considered relevant to enlightened sexism because, as supported by clinical psychologist Paula J. Caplan, it advertises to women who are simply experiencing PMS that they are mentally ill and need to seek uneeded medical treatment. Other researchers such as Renay Tannar have labeled PMDD and PMS as socially constructed illnesses, meaning mock illnesses simply created by a patriarchal society in order to continue to oppress women. Past feminist critiques of the medication and illness have rested on the belief that, when women believe they have a mental illness related to the menstrual cycle, this perpetuates stigma surrounding womanhood and isolating women from positions of power in societal structures due to the belief that their nature is so different than that of men's. Such discourse has caused Sarafem, or any use of fluoxetine as a treatment for PMDD, to maintain it's controversial status as a therapeutic drug

1398:

box warning? When you say, "secondary sources or it stays out", you seem to be saying that primary sourcing of controversial material violates policy. I also note that you don't seem to care that Jytdog was misrepresenting OR; are you here with your editor or admin hat on? I think you are misrepresenting policy; you are implying that under Knowledge policy, primary sourcing is unacceptable for controversial material, and that's simply false. Do you deny implying that, or are you willing to state for the record that you believe that under Knowledge' OR policy, primary sourcing is unacceptable for controversial material? As far as what practice emphasizes: balanced enforcement of policies should be the rule, not the exception. Editors shouldn't selectively enforce policy in a way that favors views they personally like. --

883:

seratonin isnt the only chemical in the brain that effects mood. but yes prozac is definatly personality modifying.... mood and personality are very related. also prozac takes a while before it takes any effects and those effects can range from off the walls manic to suicidal. and mixing ssri's with any other meds that in anyway effect serotonin can be dangerous. im on prozac for clinical depression. It helps alot with the depression but I can also notice a change in brain chemical lvls, it boosts both seratonin and dopamine, and it gives me a feeling similar to CNS stimulants where im very outgoing, analytical, want to fix things and help people, and become very talkitive.

609:

quickly (to replace revenues lost by the prior drug not being approved), so Varapen, working in Sweden at the time, determined from the key opinion maker players in that country what it would take to green light acceptance of the drug--answer: under the table cash payments and contract work awarded for clinical trials. (2) Varapen claims to have obtained letters (supposedly published on the Internet) from German officials who were quite negative on prozac, however, one year later, and the German government approved the drug. When Varapen asked Germans what new studies had been published that changed their minds, no responses were forthcoming.

3744:

develop agents that inhibit the uptake of 5-HT from the synaptic cleft were initiated. These studies led to the discovery and development of the selective serotonin-reuptake inhibitor fluoxetine hydrochloride (Prozac; Eli Lilly), which was approved for the treatment of depression by the US FDA in 1987. Here, we summarize this research and discuss the many challenges that we encountered during the development of fluoxetine hydrochloride, which has now been widely acknowledged as a breakthrough drug for depression.

1585:

With the backing of the medical community, the pharmaceutical company Eli Lilly & Co. was able to take Prozac, change its color, packaging and name to “Sarafem” to sell as the market’s only drug for PMDD. Following the release of Sarafem was a flood of marketing techniques that came from Eli Lilly & Co. to sell the drug. Eventually other pharmaceutical companies followed Lilly’s suit and did the same with their own version of Prozac, generic or not, to create their own version of Sarafem to sell.

3521:"In the deepest sleep phases, cerebrospinal fluid rushes through the brain, sweeping away beta-amyloid protein linked to brain cell damage. Without a good night’s sleep, this housecleaning process is less thorough, allowing the protein to accumulate—and inflammation to develop. Then, a vicious cycle sets in. Beta-amyloid buildup in the brain’s frontal lobe starts to impair deeper, non-REM slow-wave sleep. This damage makes it harder both to sleep and to retain and consolidate memories." 2799:. In this case the authors' editorializing is not even particularly necessary, in looking at the CSR data it is obvious that there was misreporting to the extent that the studies, which were subsequently included in the meta-analyses above, cannot be relied upon. In any case, to describe them as "questioned" downplays the issue quite a bit. Perhaps a disclamatory sentence is suitable: "According to a 2022 restoration, the studies....were flawed and misreported." 31: 1193:"Directories, directory entries, electronic program guide, or a resource for conducting business. For example, an article on a broadcaster should not list upcoming events, current promotions, current schedules, etc., although mention of major events, promotions or historically significant program lists and schedules may be acceptable. Likewise an article on a business should not contain a list of all the company's patent filings. 1589:

premenstrual symptoms, she is actually suffering from PMDD. This first commercial was soon removed from air after the Food and Drug Administration deemed it to undermine the seriousness of PMDD, which had already been receiving much criticism for not being a legitimate disorder. The advertisement had at the same time been criticized by feminist scholars, and the incident has since become a niche focus within feminist studies.

3057:

trials were conducted and their results presented at the time, and the authors point out that it does have some limitations due to missing data within the control trial reports that was either omitted, unrecorded, or censored. I would be somewhat wary of relying solely on PubMed's metadata in determining whether or not this is a review, as metadata can be incorrect, but I would be interested in hearing what

2576:

is also true for other or all Canina et cetera. That seems artificial and unreasonable, and would be a major departure from current status. The average person who visits the page Fluoxetine probably expects both kind of information, that specific to Fluoxetine and that which is also true for some broader set, and it's reasonable to provide that. Also, often it's not easy to separate the two.

879:

well as anecdotal accounts from psychiatrists. i think this should be included due to the interesting issues it raises about personality and the underlying neural basis for it. It is also relevant in explaining prozac's widespread use even after the symptoms of depression have been curtailed. i can't remember the source, but i will put it up as soon as i find it in the library again.

2382:

the article. There really isn't much evidence specifically about whether fluoxetine increases or decreases risk of suicide in younger persons or older persons. A more nuanced discussion of this would be good for the main body of the article. I've added one meta-analysis and statement to the depression section. Perhaps there ought to be a suicide section for the fluoxetine page?

2640:

found a 50% increase of odds of suicide-related events, not reaching statistical significance, in children and adolescents on fluoxetine as compared to ones on placebo. According to the MHRA data, for adults fluoxetine did not change the rate of self-harm and statistically significantly decreased suicidal ideation by 50%." It has to be summarized accordingly in the lead.

1509: 907:

anti-depressents just havnt figured out the root of the depression and all they need is therapy instead of medication, and medications arnt as safe and harmless on the body as people think. also I wish i could slap every pschiatrists who diagnosis kids with ADHD because a 7 year old is hyper and doesnt wanna listen to adults talking... its called be 7 years old.

1423:

particular profile of adverse side-effects which may perhaps, in the future give rise to the greatest clinical liabilities in the use of this medication to treat depression". In 1985 Dr. Kapit recommended "labeling warning the physician that such signs and symptoms of depression may be exacerbated by this drug". No such warning was issued until 2004.

1029: 87:. So far, so good. But there's no mention there of Reconcile. Since there's a link, we owe it to the reader to mention in the latter article that among SSSIs is also Reconcile, the chewable tab for dogs. One can glean this circumstantially (i.e. I have been sent here from there, so Reconcile must be an SSSI), but is that enough? 2867:). Whether this is one of those times is a matter for consensus, which is why I reworded and tagged rather than removed the content. Whether you can find a way to re-word within policy, I can't say (I am iPad editing from the car on a hotspot and not home to do research now), but your justification above involves mostly 2845:

two of which are the ones that have been restored. If the results from these trials might be significantly flawed it is obviously deserving of mention. Knowledge policies seem to me to indicate that where it is relevant and necessary, and in the absence of secondary literature, a credible primary source may be used.

2738:"Moreover, in obsessive compulsive disorder patients, abnormalities of myelin integrity have been found that were partially reversed by SSRI treatment. Taken together, these findings suggest that myelination is dysregulated in several psychiatric disorders and can be regulated by antidepressants, like fluoxetine." 3699:

Placing a reference to PubChem in a footnote, (in this case the 90th footnote at the time of this writing) is not equivalent to placing it in the body of the article itself. You are aware of this. Placing a PubChem reference under the "Identifier" column on the right hand side will not be observed by

3590:

The hepatotoxicity of fluoxetine has been widely observed. "Fluoxetine-induced liver damage is a cause of chronic liver disease." Karimi-Khouzani, O., Heidarian, E. & Amini, S.A. Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in

3572:

that the dose makes the poison. Many drugs used throughout medicine can be acutely toxic in large doses, as you can see on PubChem by searching other common drugs. However, at clinical doses they will not pose health hazards. The same goes for fluoxetine. Certainly there are legitimate concerns about

2844:

The first point is fair, my bad, and as I suggested the point could be reworded. To describe a clinical trial restoration as "only someone's opinion" borders on the absurd. The meta-analyses and systematic reviews regarding the efficacy of fluoxetine in childhood depression rely on only a few trials,

2794:

Apologies as I am quite new to wikipedia, but familiar with antidepressant research and it's unclear to me why the edit regarding the restoration of pediatric fluoxetine trials was reverted. In this case a primary source is relevant and necessary. Clinical trial restorations are not often going to be

2575:

My example was paradoxical. That policy is not usually applied in Knowledge, and it wouldn't be wise to do so. Think for example about animals, another field with a rich taxonomy: the page Dog would not contain anything which is also true for other or all Canis, which would not contain anything which

2541:

I disagree in principle with that reasoning. You are arguing that the page Fluoxetine should _only_ contain information specific to fluoxetine, and delete _all_ information which is also true for all SSRIs. Applying again that principle, than the page SSRI should not contain any info that is true for

1856:

in recent mass culture. Some critiques about Sarafem, as supported by clinical psychologist Paula J. Caplan, are that it advertises to women who are simply experiencing PMS that they are mentally ill and need to seek unneeded medical treatment. Other researchers such as Renay Tannar have labeled PMDD

1789:

I looked at the revision history before seeing your talk page post. Given your argument, I decided to delete the content relating the pharmacodynamic effect to a clinical effect; I retained the SBSS terminology because it's technically an accurate description of the pharmacodynamic effect, but I dont

1584:

PMDD was added to the widely used psychology manual called DSM in the early 1980s. This medicalization of the menstruation cycle stated that severe shifts in mood—along with common symptoms of PMS—that have had an affect on a woman’s personal life during the luteal cycle are means for PMDD diagnoses.

1344:

WEIGHT needs to guided by the sources, and ideally secondary sources- this is what NPOV says. I'll acknowledge that it is me saying that doing otherwise is OR. Probably more importantly, providing long quotes from one side in a controversy just invites long quotes from the other side. What we do

432:

It figures this is the kind of response I would get. I might as well go on Wiki Answers, where I'll get the response of "Duuuuuhhhhhhrrr i dont know but ill answer anyway!!!!! :)" or else have the question just fester there, unanswered. I suppose it wouldn't really make a difference, considering what

335:

which puts them both in the class of antidepressives refered to as NDDI's(Stahl). In the case of Fluoxetine the NDDI effect is assumely mediated only in the prefrontal cortex. This mechanism is also claimed to be responsible for the quick anti-depressive reponse the patient gain from it. Which can be

3707:

On a further note, I must request that the assertion that fluoxetine is acutely toxic appear "above the fold," preferably at the end of the first paragraph. Psychologically, readers typically remember and absorb the first few paragraphs more than the paragraphs which follow, especially in a lengthy

3670:

All drugs are chemicals so this is a false dichotomy. Indeed, if fluoxetine is deemed to be acutely toxic in the lab, those dealing with the drug would be required to wear protective gear when handling the drug. Ingesting the drug would expose an individual to substantially greater harm, so you are

2501:

Fluoxetine is different from other SSRIs. It is the only SSRI that works in children and, in addition, unlike other SSRIs, it does not make them more aggressive and unruly (the scientific word "disinhibited"). So, it looks plausible that fluoxetine, unlike other SSRIs, may have some positive effects

2381:

There isn't much evidence that fluoxetine reduces suicide risk. It may increase suicide risk in younger patients. I removed the statement in the lede about possible reduction of suicide risk in people older than 65, as this is not supported by the given citation, contradicts info in the main body of

1905:

I struggle with this for a few reasons. first, it is not in dialogue with the rest of the article, which touches on this topic. This seems to perhaps be a class assignment? Secondly, it portrays "feminists" as speaking with one voice on this issue and actually does the typical male/sexist maneuver

1332:

You misrepresent OR. 2)I didn't introduce OR. What we need is for you to ground your objections with specific quotes from policy. Because you misrepresented OR. AGF is not a suicide pact. I don't think policy supports you so I'm restoring the user's content unless you can show otherwise. And I

565:

I removed the citation "NTP_CERHR Expert Panel Report on Reproductive and Developmental Toxicity of fluoxetine" from the claims that "Similarly to other SSRIs, sexual side effects are common with fluoxetine; they include anorgasmia and reduced libido." I could not find decreased libido or anorgasmia

541:

I deleted the additional comment about non statistically significant increases in violence being "alarming". The reason we analyze data with statistics is to measure the likelihood that the difference between treatment and control groups is due to chance. Thus using a non-statistically significant

3711:

As a separate but related matter, I must also request that the "Adverse Effects" also appear above the fold. Even on TV, when a drug is advertised and described, the pharmaceutical company advertising the drug is required to immediately thereafter identify significant "side effects" of the drug. On

3687:

The editor knows that he's won't "win" by stating that is not, so instead attacks the relevance of MEDRS. The purpose of MEDRS is precisely the opposite of what the editor claims. It is meant to verify reliable and pertinent sources. PubChem is MEDRS and reliable, which is consistent with the vast

3678:

This first sentence is an example of a type of projection. The comment that Pubchem's identification of fluoxetine's acute toxicity is a red herring is itself a red herring. The drug is acutely toxic to the liver, if not other organs as well. I suspect the editor knows that PubChem is MEDRS (it is)

3456:

With respect to the first sentence, I think you understood the idea I was conveying, and are not being entirely intellectually honest. With respect to the second, I wrote an e-mail to NIH for clarification. In the meantime, I'm assuming that NIH conducted a diligent review before characterizing the

2666:

Because there were making tons of money! Furthermore they tried to discredit scientific studies about dangers of Prozac, which claim it cause serious side-effects, seems familiar? It scares me, that there is not more info! Even at current time psychiatrists still promote SSRIs, which are unhealthy,

1774:

edits, Seppi, but I struggle with elevating this one lab's pet theory to fact. The only four reviews are by him; this notion of SBSS is not getting taken up and in my view it isn't appropriate for WP to elevate it. I'm OK with keeping the biochemical stuff in the PD section if we remove the SBSS

1592:

The modern development of PMDD, and the more recent creation of Sarafem, has been critiqued by feminist scholars as an industry that supports the spread of enlightened sexism in recent mass culture. Enlightened sexism is the name the modern feminist movement uses to describe a resurgence of female

1536:

Following this, there is a brief explanation of what PMDD is and its presence in the medical community. We then explain how Prozac was rebranded into Sarafem, causing the entire pharmaceutical industry to follow suit with their variations of Prozac. After this we talk about the marketing and media

1532:

The sentence we follow with our history of Sarafem is as follows "Prozac was rebranded for the treatment of PMDD in an attempt to stem the post-patent decrease in Eli Lilly's sales of fluoxetine." This sentence itself we are editing to define what PMDD is, so instead it reads "Prozac was rebranded

1180:

unless there is a source and a justified reason for the mention. Encyclopedic significance may be indicated if mainstream media sources (not just product reviews) provide commentary on these details instead of just passing mention. Prices and product availability can vary widely from place to place

887:

Just my personal opinion, but I must say that prozac and other drugs just like it are way over-prescribed. While it is true that it does indeed have it's uses, I do not believe in diagnosing a 3rd grader with ADD and putting him/her on Prozac. To say the least, a 3rd grader is a child, and as such,

878:

don't know if this should be included in the new edit, but there is evidence to suggest prozac modifies personality. The problem being here that there is little quantifiable data measuring personality. to my knowledge there are no papers about this aspect but there have been a few books about it as

436:

Medical advice? What the hell kind of "medical advice" would this be? It just requires a straightforward answer based on facts. I'll be going to my psychiatrist on Monday (Which, by the way, happens to be June 18th, AUTISTIC PRIDE DAY!! Be sure to support it. I know I LOVE my AUTISTIC BRAIN!!). And

223:

In a small minority of Prozac users, it has been noted by some psychiatrists that Prozac can transform a person's personality . This effect received substantial publicity in the early 1990's, when noted psychiatrist Peter D. Kramer coined the term, "cosmetic psychopharmacology." The idea being that

3695:

RE: "Also: there is a link to the PubChem entry in the article. So any reader can click on the link to get the details (almost all of which are minutiae that don't belong in the article) of toxicity and all the other PubChem stuff. So calls of "censorship" are overblown. Wait until someone deletes

3286:

Yeah, it is potentially toxic, if taken in large enough quantities - far beyond prescribed dosages. As are pretty well all pharmaceuticals, if you exceed the recommended dosage by enough. Along with more or less every other substance known to humankind. Don't let the door hit you on the way out...

2639:

Here is what the subchapter on suicide specific to fluoxetine in this article states: "Considered separately, fluoxetine use in children increased the odds of suicidality by 50%, and in adults decreased the odds of suicidality by approximately 30%. Similarly, the analysis conducted by the UK MHRA

1935:

Giving my own opinion here. I find it kind of sexist that just because a person is born with a uterus and has to suffer periods their whole life that there should be no medicine to help deal with that. Its almost as sexist as the notion that women should be forced to pay for contraceptives while

1528:

The changes made to the page on Fluoxetine are all being done in the section entitled "History"; in this section we are adding a more detailed summary of the history of Sarafem and its use to treat PMDD. Since there is already a brief statement on Sarafem in the history summary, we are adding our

1464:

Certain clinical risks of mild to moderate severity did appear to be associated with the use of fluoxetine; as determined by a review of the safety data in this NDA submission. These potential risks include intensification of the vegetative signs and symptoms of depression, reduction of hemoglobin

1397:

to minority views" presupposes that the quote I added in which the FDA's (then) chief safety investigator, Dr. Richard Kapit, advocates an adverse side-effects black box warning expresses a minority view. You think it's a minority view? How so, since FDA DID mandate an adverse side-effects black

906:

I agree they are over-perscribed. so are disorders like ADHD, Bi-Polar, and autism spectrum disorders. I wanna be a psychiatrist and I think that psychiatrists should try finding the root of problems like depression instead of just a quick chat and a perscription, I guarantee that 50% of people on

545:

David Healy's position, while getting a lot of attention from the mainstream media and anti-psychiatry activist groups, is not mainstream. Without the added material, this non-mainstream position is already accorded equal weight with the recommendations of the American Psychiatry Association, and

448:

First I need some help. I'm coming to you for help. This is an article pertaining to Fluoxetine. You're not saying that NOBODY here knows ANYTHING about the drug they're writing about, are you? I'm not asking about anything particularly dangerous, such as weaning myself off of meds. This I will do

389:

I am an Asperger's/Autistic person and I love my Asperger's/Autistic brain, though I was manipulated into taking the drug Prozac by a psychiatrist when I was younger and suffering from an illness thought to be psychological which wasn't psychological at all. And therefore I was desperate to accept

3642:

Also: there is a link to the PubChem entry in the article. So any reader can click on the link to get the details (almost all of which are minutiae that don't belong in the article) of toxicity and all the other PubChem stuff. So calls of "censorship" are overblown. Wait until someone deletes the

3627:

The main point is the first point - about any chemical being toxic if taken in large enough quantities. This article is about fluoxetine as a 'drug', not about fluoxetine as a laboratory 'chemical'. Making statements about its chemical toxicity would mislead the public. All the conversation about

3594:

Fluoxetine has a logP of 4, meaning it is highly lipophilic, as is its major metabolite, norfluoxetine which exhibits a logP of 3.5. Drugs that are highly lipophillic, and which are extensively metabolized by the liver, are often markedly hepatotoxic. In addition both fluoxetine and norfluoxetine

3527:

3) Fluoxetine and its major metabolite, norfluoxetine, potentiate 5HT2C, which activates the central nucleus in the Basal Lateral Amygdala. This activity potentiates neuropathic pain as well as emotional-affective and anxiety- and depression-like behaviors. Ji, Guangchen, et al. "5-HT2C receptor

3056:

pyramid. It's clear as to which control trials it is analysing, and how the authors reached their conclusions based upon the data available within those trials. It does diverge quite significantly from the original reporting of the trials by Eli Lilly, as a result is is very critical of how those

2337:

asked to be buried in a big Prozac capsule and that this wish was granted. But I'm not personally adding all of this to the article because I am not currently willing to track down sources to back this up. I may do so later, or someone else can feel free to. I also think it's worth getting a more

440:

I was hoping there would be someone here with a real sense of ethics, someone familiar enough with the effects of pharmaceutical drugs who could help me by answering a simple question. I mean, there has to be SOMEONE here with the expertise to help. It's just that they don't WANT to help me, even

694:

Hi, people, I am writing to ask whether you's would accept it if I was to write a symbol, say † to indicate life-threatening/(usually) irreversible AEs like serotonin syndrome, tardive dyskinesias, etc. And other symbols (‡, #, ¤) to indicate other types of AEs, i.e. transient ones (e.g. nausea,

589:

further information. Virapen is of India ancestry, was born in Guyana, moved to Europe when he was young to be educated in the medical field. Instead of a M.D. he got a PhD in psychology or similar such. He was recruited to become a marketing / sales person in the pharmaceutical industry. Google

524:

I think he has a point, I feel like shit now after taking Prozac. Cannabis is much better for dealing with western capitalism and it's effects on mental health than SSRI's. I strongly believe that the system as it is in western societies is a major factor in depression, suicide and mental health

289:"The double-blind controlled studies support this opinion. No increase in side effects was observed in several studies when the treatment with fluoxetine was blindly interrupted for a short time (4–8 days) and then reinstated, this result being consistent with its slow elimination from the body." 202:

As for the popular books and news articles, they are used in the "non-medical" parts such as History and describe "non-medical" facts: sales, patent expiration, court procedures, press reaction. You could, perhaps, insert the "character changes" hypothesis into the popular culture or controversy

123:

I took the liberty of adding this section in again with references. I think to have a wikipedia page on Prozac, and not mention its personality changing effects once, is kind of misleading. Although it only happens in a minority of people, the whole reason it became popular as an AD in the first

3598:

With chronic use (12 weeks or more, which is usually required to putatively observe therapeutic effect), the concentration levels could violate Chen's rule of two, even though the dose of the drug would not meet the criteria. The reason is that Chen's rule of Two is ostensibly predicated on the

3386:

of reliable medical sources that the toxicity of fluoxetine is a significant topic within fluoxetine research, it can be considered for adding into the lead. A medication's entry on PubChem is not MEDRS compliant, nor is it a peer-reviewed systematic review of of the relevant literature on that

1248:

I just don't see what it really adds. Our article on automobiles doesn't contain a comprehensive list of every local brand of car made anywhere in the world. Nor do our articles on gasoline, televisions, oatmeal, epoxy glue, or personal computers. In the case of generic drugs, it is even less

3743:

In the early 1970s, evidence of the role of serotonin (5-hydroxytryptamine or 5-HT) in depression began to emerge and the hypothesis that enhancing 5-HT neurotransmission would be a viable mechanism to mediate antidepressant response was put forward. On the basis of this hypothesis, efforts to

3663:

The pertinent inquiry is whether Fluoxetine is acutely toxic at the doses that the FDA and other regulatory bodies across the world have approved the drug. As I state in my response to Feline negativity, fluoxetine is acutely toxic to the liver in doses approved by the FDA and other regulatory

3602:

Even though you may argue that this is evidence of non-acute toxicity, this is not the case. Toxicity in vivo takes longer to manifest than in vitro studies such as HepG2 would disclose. The liver is a fairly resilient organ, which means that often even acutely toxic drugs will not cause liver

608:

and several books that he wrote about the dirty deeds with which he was involved while working in the pharmaceutical industry. (1) One such item is that when a prior drug from the company development pipeline failed to be approved, next up was prozac. Eli Lilly & Co wanted prozac approved

444:

I'm telling you I've been F**KED. So now YOU have to tell me what to do about it, as a decent human being. My creativity, my energy, my drive and focus and determination, I want it ALL back!! My unique and vivid perception of the world, I want it BACK!! That way I can expose the Pharmaceutical

2817:

Since it's not a secondary review, we can't state it as fact in Wikivoice. It's only someone's opinion, and it's unclear if it belongs in the article at all. I gave it the benefit of the doubt by merely tagging it. Looking at the underlying data and making our own conclusions about them is

1422:

In contrast, in May 1985, FDA's (then) chief safety investigator, Dr. Richard Kapit, wrote: “Unlike traditional tricyclic antidepressants fluoxetine’s profile of adverse side effects more closely resembles that of a stimulant drug than one that causes sedation". He warned "It is fluoxetine’s

882:

any med perscribed to alter mood will either bring out your true personality or create another one. It's all dependant on how depressed someone is and why. if someone with bi-polar is giving an ssri it will get rid of there depression but make there mania more frequent and more intense. also

1588:

The first commercial marketing Sarafem depicted a female struggling to release a grocery cart from a line of others and becoming increasingly frustrated and overwhelmed by the situation. As this is happening, a male voice over explains that while this woman thinks she is simply dealing with

359:

1. Please cite references. Possible reference material: Zhang S, Li B, Lovatt D, Xu J, Song D, Goldman SA, Nedergaard M, Hertz L, Peng L. 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake

2931:

Though I do not have the full text to confirm, I would query if this is actually primary research given that on the surface it does not look like the authors have conducted the underlying clinical trials which they are reviewing some 23-27 years after the fact. I'll stick in a request at

1519: 1470:

It is suggested that labelling be developed which advises physicians about possible exacerbations of the vegetative manifestations of depressive illness and about the possibility of decreases in hemoglobin. The occurrence of LDH elevations should be mentioned. If this drug is marketed,

1458:

Fluoxetine appears to be a relatively safe drug. If it can be demonstrated that treatment with fluoxetine significantly benefits patients with depression, it would appear that the benefits of treatment with fluoxetine would substantially outweigh the risks associated with this drug.

2332:

It should probably be mentioned that, for better or worse, fluoxetine (specifically as "Prozac") is one of the drugs most associated with the term "antidepressant" in American culture, and it often figures both in praise and criticism of antidepressants. I have definitely read that

933:

Suggest adding that Fluoxetine acts not only as a selective serotonin reuptake inhibitor (SSRI), but also as a selective brain steroidogenic stimulant (SBSS), even at levels too low to affect serotonin reuptake . Specifically, it can stimulate the production of allopregnanonlone

3703:

People will more likely notice, read, and be informed by a statement made in the body of the article than if it is in a footnote. Even if a reader notices that it is part of a footnote, that individual may reasonably attribute less weight to it than if it were in the article

3338:

Knowledge cannot allow editors to delete highly authoritative, unbiased, and verifiable sources and citations simply because it is inexpedient, may cause law suits, a decline in drug's sales/revenue, or for any other reason. The NIH is one of the most authoritative sources

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RE: "All the conversation about whether PubChem is MEDRS is a red herring for the purposes of this discussion. Even if PubChem were MEDRS (and it might be), the PubChem assignment of chemical toxicity would not support a statement in this article that fluoxetine is

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vomiting), ones that may lead to permanent damage if it persists in the long-term (e.g. hypertension) and those that can, but usually are not irreversible. I will be editing the page to include this, if you object to it, feel free to change it back the way you like.

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If you are able to find the literature, a couple of sentences about the personality changes would be warranted in the section on side effects. More material could be distracting -- the space in the article should be proportional to the significance of the

265:; good responders noticed that not only did Prozac lift their moods, but it also made them feel good about themselves; a handful of users reported that while on the drug they felt more like themselves, but this effect quickly diminished while off of it. 3514:

1) Fluoxetine disrupts sleep architecture, specifically decreasing sleep continuity and slow wave sleep. Wichniak, Adam, Aleksandra Wierzbicka, and Wojciech Jernajczyk. "Sleep and antidepressant treatment." Current Pharmaceutical Design 18.36 (2012):

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2) Furthermore, could you support your conclusion that a citation must satisfy the requirement of constituting a "peer-reviewed systematic review of the relevant literature." If that's the standard, almost all citations would need to be expunged.

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OK. That sounds good. If I were able to find the aforementioned articles, I think it would be wise to add this section back in don't you think? There are also news articles and other books, in the main Prozac article, why are those not changed?

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depending on how you want to handle the bracketed portion in Sideswipe's proposed text above, I will leave the honors of rewriting/re-inserting to you. My sincere apologies for the extra work, but I hope we ended with a solid and better result.

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A 2022 systematic review of original blinded-control trials used for approval of fluoxetine use in children and adolescents with depression found that both of the control trials were severely flawed, and did not demonstrate the efficacy of the

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either on my own or with my psychiatrist's help. However, I think the long-term effects of Fluoxetine is an interesting question that people would want to know about. Perhaps information about it should be included within the article itself.

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whether PubChem is MEDRS is a red herring for the purposes of this discussion. Even if PubChem were MEDRS (and it might be), the PubChem assignment of chemical toxicity would not support a statement in this article that fluoxetine is toxic.

2735:-- which ties together the existing body of literature pretty nicely. One of the main underlying pathways appears to be the upregulation of genes responsible for controlling myelination. A really nice summarization from this paper reads, 3595:

have a very long half lives (4-6 days with chronic use), causing bioaccumulation over time. As a result, the dose is nort commensurate with blood concentration levels or liver burden when taken chronically consistent with clinical use.

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Sorry, Knowledge cannot give any medical advice. The doctor who prescribed your medication is your very best route. Otherwise, suggest you try a chat group or notice-board site that specialises in medication or health issues. Thanks.

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we might use medication to improve work performance, redesign a person's personality, or improve resilience; and to make people more attractive, more energetic, or more socially acceptable . Peter Kramer's seminal book on the topic,

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Thinking we should consider adding a section on (or at the very least, a reference to) the neuroprotective/neurogenic mechanisms that underpin the use case of Fluoxetine in patients with OCD pathologies. I recommend drawing from;

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If the person deleting the citation doesn't want to take it seriously, then that's his prerogative, but it is not his prerogative to impose his interpretations and opinions of the source/citation on everybody else by deleting

1317:, the OR here is using a primary source and giving a bunch of WEIGHT to it, even quoting it. What we need is a reliable secondary source that gives significant weight to what Kapit said. Has nothing to do with what he said. 475:

In the book Bad science : quacks, hacks, and big pharma flacks by Goldacre, Ben the author has a chapter about Fluoxetine, he claims Pfizer manipulated the clinical trial results to make it look like this drug is effective.

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I did not say that "fluoxetine is not MEDRS compliant". I said that a medication's entry on PubChem is not MEDRS compliant. Fluoxetine has had many published papers on it that meet the criteria of MEDRS, and are cited in the

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1. Kroeze, Y et al. “Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus.” Translational psychiatry vol. 5,9 e642. 22 Sep. 2015, doi:10.1038/tp.2015.145

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With respect to the content above, just a gentle reminder that this space is for the discussion of how to improve the Knowledge article, rather than a general discussion forum of the topic. Many such forums exist elsewhere.

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I moved the paragraph in question below for further work. The sources you used do not pass the muster for acceptable sources in medical articles. The definition of reliable source is much stricter for medical articles, see

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According to a PubChem representative, PubChem is part of the "National Library of Medicine." The representative stated as follows: "We report data from high quality sources and list the source as the reference with their

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This is a talk page for discussing improvements to our article on Fluoxetine. It is not a forum for discussion of the drug, and in any case, we do not give medical advice on Knowledge. Please ask your questions elsewhere.

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The 3D graphic under the line drawing should be reversed (flipped 180 degrees) so that it matches the line drawing. As it is represented now, they are reversed, and require the viewer to mentally flip one or the other.

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I have been taking fluoxetine for almost 3months & the last few days have been light headed & wouldn’t want to chance driving.By evening it wears off. I intend to contact doctor but would appreciate any advice.

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If you're talking about number 3, it's actually mentioned in her article, so that would not be consistently applied in that case. However, I will admit this is a relatively trivial piece of information, so maybe not.

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prescience pf Sarafem and the controversy it sparked. Such an influence caused a lot of response and in our last paragraph we explain the feminist response, as well as the significance it has on the feminist movement.

159:. You used articles from news magazines and from a popular book by a psychiatrist based on his personal impressions. None of the sources you offered is a peer-reviewed scientific article. The paragraph follows below. 2749:

3. Alme MN, Wibrand K, Dagestad G, Bramham CR. Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural Plast 2007; 2007: 26496.

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Though I need to know something. Does Prozac permanently alter the way your brain functions, even after you quit taking it? I DON'T want my brain altered AT ALL. I WANT MYSELF TO BE THE EXACT SAME WAY I WAS BEFORE.

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Looks like it was taken from the package insert. Could be my fault. Sometimes I use the Dberri citation tool for URLs and forget to change the "type" from PMID to URL, and get funny results like this as a result.

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I am not sure it is notable enough. Having a disambig link to the article does not mean the word have to be present there. Even the often made grammar errors in the name sometimes are included into disambiguation.

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thinks in relation to this. I've also now received the version of the paper that was published in the journal from REREQ, I'll do a diff on them shortly, but at first glance they do appear to match up closely.

1737:-- all from the same person. This appears to be a "pet theory" and not accepted knowledge, so I am moving this out of all the statements of facts part of this article and moving it into the Research section. 3671:

arguing against yourself. Indeed, failing to inform the public of fluoxetine's toxicity through this platform, employing spurious reasoning, obfuscation and pretext, would constitute lying through omission.

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Sure so the question appears to be should we contain a list of brandnames for a product? If there are refs I do not see anything really wrong with it as long as they go low in the article and not the lead.

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A meta-analysis of 24 placebo-controlled trials in over 4400 children and adolescents showed that for every 1000 patients treated with drug instead of placebo, there were 14 additional cases of suicidality

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was written by a female nurse, and actually does a pretty good job of laying out the hype and the reality (and makes it clear that at of 2002, there were women who actually have PMDD, rigorously speaking).

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4. Fan Q, Yan X, Wang J, Chen Y, Wang X, Li C et al. Abnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication. PLoS One 2012; 7: e35889.

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I'd suggest this quote, in particular, because of the relatively plain language used by the authors here. If the proposed addendum ends up needing more support, I've included a few more sources below.

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What opinion do the studies support? There are several statements in the article before the first quoted sentence, and it is unclear to which of these statement the statement "... support this opinion"

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The diff would be with the version prior to the one shown. I have re-added a bit of (condensed) text from that version -- hopefully the story is clearer now. Thanks for pointing out the problem.

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If I'm parsing the abstract correctly (alas I can't access the full text), this seems to be a review of two separate placebo-controlled trials that were conducted by Eli Lilly and Company between

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I think it's unlikely you'll get a reply from the National Institutes of Health. However, the safety data on PubChem regards industrial production and laboratory use. It's a basic principle of

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and over time. Knowledge is not a price comparison service to compare the prices of competing products, or the prices and availability of a single product from different vendors or retailers."

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result as a counterpoint to multiple studies which showed a statistically significant reduction in violence upon treatment with fluoxetine and other SSRI's is inappropriate and undue weight.

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respectively. The authors of the 2022 paper; Gøtzsche and Healy, do not appear to be connected with either of the two studies, and it looks like Gøtzsche has been working on this since circa

3440:, it would need to be cited to a peer-reviewed systematic review of the literature on fluoxetine that states that fact. A medication's entry on PubChem does not meet those requirements. 2520:

Well, if that is so, and good MEDR secondary sources could be found, this could be added to the article. I think the general effects of SSRI's on "disinhibition" should be dealt with at

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its medical use, as with other SSRIs, such as suicidality or withdrawals, but if fluoxetine were acutely toxic at the doses used in clinical practice it would have been noticed by now.

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That's censorship. Why not let people decide for themselves without Knowledge arrogating the authority to decide for them? Just point out that it isn't peer reviewed, if that's correct.

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The person deleting the citation to fluoxetine's toxicity is also exhibiting disrespectful conduct, in violation of Knowledge rules, i.e. "Don't let the door hit you on the way out..."

3047:, but doesn't cite a source for this in the relevant passage of the text. Do we know what meta-analysis he's referring to? This seems as though it would also be useful for our content. 2010: 1936:

men get Viagra paid for or that abortions should be illegal. Really? Women should just be determined by their biology and the medical establishment should do nothing? Is biology

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Several other reputable sites are reporting that Prozac has been classified category C. I've changed this page to reflect this data, although I was unable to personally verify.

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article as this one is. Furthermore, many readers do not scroll down, or if they do, gloss over the content. In this article, "Adverse Effects" are discussed way below the fold.

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compliant sources that support the content you wish to add. That content must first be added to the article's body, in a manner that complies with core content policies like

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But now I REALLY don't want it and I liked myself the way I was before. Am I permanently changed by the drug? I started taking it when I was 16 and now I'm 21. HELP please!

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Re: "This article is about fluoxetine as a 'drug', not about fluoxetine as a laboratory 'chemical'. Making statements about its chemical toxicity would mislead the public."

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a review. In particular, it can take a couple of months for this information to appear in PubMed. Also, reviews frequently weren't marked as such in the previous century.

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Quick note to say I've done a diff between the file linked above, and the one I received from REREQ which was acquired directly from the journal, both files are identical.

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string looks like. I believe that when PubMed fails to classify something that says it's a review as one, there's usually a good reason, but Bon courage will know better.

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6. Yune TY, Lee JY, Kang S. Fluoxetine prevents oligodendrocyte cell death by inhibiting microglia activation after spinal cord injury. J Neurotrauma 2015; 32: 633–644.

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2. Mechanism of action of Fluoxetine as with all SSRIs (cited many times on Knowledge) is unknown- but presumed. Please include this distinction in this article as well.

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the treatment guidelines of agencies such as the National Institute for Health and Clinical Excellence. It seems to me that this is more than a fair level of coverage.

652: 2601:. We're here to discuss Fluoxetine. But WP is rife with duplication. It's really not needed in an electronic encyclopaedia - after all, we have hyperlinks, don't we. 2954: 2917: 2921: 2757:

5. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000; 20: 9104–9110.

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So not even close to the alarmist document that it was being made out to be. This is why we don't cherrypick primary sources. Cherrypicking is a form of OR, per

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Can this insider witness' confessions to "drug company wrong doing" be used in the article since he specifically identifies prozac as the focus of his key story?

3463:"According to PubChem's entry for Fluoxetine, Fluoxetine is identified with an acute toxic 'skull and cross bones' and 'health hazard' pictograms, among others." 304:

Both of the quoted sentences lack citations in spite of their speaking of studies; possibly they are implicitly cited in - Fava M (2006), but that is not clear.

1733:, someone suggested adding content about a putative "selective brain steroidogenic stimulant" effect, and it was done. I just looked into pubmed on this, and 247:; instead of being though of as a pleasure pill, Kramer redefined Prozac's therapeutic efficacy by noting that Prozac restored one's capacity to feel pleasure 2795:

found in a review, and they're not going to be making it to other secondary sources unless there's some sort of gross misconduct that results in scandal à la

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failure immediately. It would manifest slowly but progressively faster as the integrity of liver becomes increasingly damaged and functionally compromised.

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category. In that case, it would still be very desirable that this hypothesis either confirmed or debunked by an expert opinion from a peer-reviewed article.

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2) Fluoxetine, by decreasing slow wave sleep, impairs the ability of the brain to wash away amyloid beta and other toxic material via the glymphatic system.

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The modern development of PMDD, and the more recent creation of Sarafem, has been critiqued by feminist scholars as an industry that supports the spread of

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Industry for the crooks, liars, and frauds that they are! Psychiatrists are agents of the industry and they are criminals, child abusers and mind rapists.

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Kramer, P. D. (1993). Listening to Prozac: A Psychiatrist Explores Antidepressant Drugs and the Remaking of the Self. New York: Viking Adult. p. 144-196.

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Holmes, S., Lauerman, J., & Gordon, J. (1994, February 7). The Culture Of Prozac | Newsweek Culture | Newsweek.com. Retrieved October 20, 2009, from

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PS, you might also want to go ahead and get the actual source, as we can't be certain that the self-published version is the same as what was printed.

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This seems pretty straightforward: primary sourcing is acceptable for uncontroversial material but Knowledge policy and practice emphasises the use of

2011:

https://web.archive.org/web/20121215070930/http://drugtopics.modernmedicine.com/drugtopics/data/articlestandard//drugtopics/252011/727243/article.pdf

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of taking one or two examples and claiming that they represent Reality. Third it presents only one side of what it calls a "controversy". But see

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This talk page is for discussions relating to improving the Knowledge Fluoxetine article. It is not a forum for general discussions of the subject.

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either I've been screwed by the shrink or quitting will make my brain revert to the way it used to be. Either there's hope or I'm just left to rot.

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The National Institute of Health has determined through a comprehensive review of the medical literature that Fluoxetine is an accutely toxic drug.

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b) Journal would seem to be reputable, editorial board has a number of prominent pharmacovigilance experts and the publisher isn't on Beall's list.

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Suggest adding the following under the heading Medical Uses: Fluoxetine is also indicated in the treatment of PMDD, which is a severe form of PMS.

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Were the X065 and HCJE trials the only two blinded-control trials done as part of the approval process for fluoxetine in children and adolescents?

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The NIH does not designate drugs as "acute toxic" with a skull and cross bones for nothing. It doesn't mean "only if you ingest a large amount."

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One information source, a radio talk show interview, led me to research drug company confessions of an insider that led me to the information on

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That said i see the point of the critique - namely the male-driven establishment painting women as hysterical and medicating them. That is

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for the treatment of PMDD—premenstrual dysphoric disorder—in an attempt to stem the post-patent decrease in Eli Lilly's sales of fluoxetine."

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How well regarded and how impactful is the journal (International Journal of Risk and Safety in Medicine) Gøtzsche's paper was published in?

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all Antidepressants, and so on. That doesn't seem reasonable at all. It would also imply deleting most of the article as it is currently.

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made three edits. J, you only attempted to justify your revert of one. There's no plausibly valid policy violation allegation here. --

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https://web.archive.org/web/20130525023854/http://www.benthamdirect.org/pages/content.php?CNSAMC%2F2009%2F00000009%2F00000003%2F0006T.SGM

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illnesses. Such discourse has caused Sarafem, or any use of fluoxetine as a treatment for PMDD, to maintain a controversial status as a

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Having read through this paper now, it does appear to meet the definition of a systematic review, which would put it pretty high on our

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to me. This is something that happens with student assignments at times; we need to pay mind to WEIGHT in the overall article, always.

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knockdown in the amygdala inhibits neuropathic-pain-related plasticity and behaviors." Journal of Neuroscience 37.6 (2017): 1378-1393.

1910: 1112: 2875:, where others might be able to engage and help out here more quickly and ably than I can right now. I'll put a query there next ... 2692: 1267: 895: 181: 3717: 3608: 3556: 3533: 3471: 3413: 3351: 3329: 3312: 3276: 3712:

Knowledge, it should be the same. "Adverse Effects" should not appear below the fold in this or in any article pertaining to drugs.

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I request Knowledge ban the culprit, come to a compromise (which must include this source), or I will quit the platform in protest.

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2. Pittenger C, Bloch MH. Pharmacological treatment of obsessive-compulsive disorder. Psychiatr Clin North Am 2014; 37: 375–391.

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It is really simple: if a statement is true for fluoxetine based on reliable sources and is notable enough to include - it goes in.

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Yup it may be that increaases suicide in young people but decreases it in older people. We mention both. There IS a suicide section

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When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

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When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

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https://en.wikipedia.org/Wikipedia:Reliable_sources/Noticeboard/Archive_306#Question_about_PubChem_%2C_Sigma_Aldrich_and_ChemSpider

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It appears like the data from which NIH bases its pictograms is more reliable and diverse than many if not all MEDRS-approved ones.

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When PubMed lists a paper as a review, we can usually rely on that, but when it doesn't say anything, that doesn't mean that it's

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https://www.scientificfreedom.dk/wp-content/uploads/2022/11/2022-Gotzsche-restoration-of-the-two-fluoxetine-trials-in-children.pdf

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The opening paragraph of the history section doesn't make much sense by itself, as it refers back to paragraph excised in change

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1) Could you support your conclusion that fluoxetine is not MEDRS compliant? I did not observe any mention of PubChem in MEDRS.

3106: 2668: 127:@Sceptical Chymist. What's your rationale for deleting in the first place? You said dubious, so I backed it with references... 2645: 2624: 2507: 2486:

Are there any side-effects, related to violence, that are peculiar to Fluoxetine and not just to all SSRIs in general? Thanks.

2416: 1227: 1135: 1105:. It is not clear why that paragraph was excided in the first place, it seems like a suitable degree of detail for this topic. 591: 208: 164: 108: 3072:

says about the metadata, I think there is a better way to phrase the sentence for this source in the article. Something like

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Hmm, I hadn't thought of that. But now you mention it, that would be a very good way of eliminating overlap and duplication.

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For the record, this is what Jytdog removed, with the outrageous two-character edit summary explanation, "OR" ('dif' above):

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https://web.archive.org/web/20131202231255/http://www.mhra.gov.uk/home/groups/pl-p/documents/websiteresources/con129100.pdf

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Should we indicate which AEs are irreversible/life-threatening with a symbol and the other types of AEs with other symbols?

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Though I recognised I could have been clearer in saying that. In order to state your proposed sentence, in that form, in

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There are articles about Eli Lilly, that they knew about its dangers, but they forced their scientists to cover it up.

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drug as "acute toxic." I will report more when I receive their reply concerning its review standards and methodology.

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As this is potentially fatal adverse effect, it should be probably mentioned directly on Fluoxetine Knowledge page.

235:; some users reported that their "moral sensibility" was gone, and their behavior was more risk-seeking than normal 3366:

If you wish to seek the inclusion of a content relating to the toxicity of fluoxetine, then you must first provide

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Given its ubiquity as the default antidepressant in American culture, this is a good idea. I'll get around tuit.

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to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the

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to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the

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http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/womens-health/premenstrual-dysphoric-disorder/

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Re: "f fluoxetine were acutely toxic at the doses used in clinical practice it would have been noticed by now."

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I did not say that all citations must be peer-reviewed systematic reviews. That remark was in reference to the

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Decided to be bold. Added a sentence to the mechanism of action. Tried to summarize as best as possible. ^-^

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Re: "The main point is the first point - about any chemical being toxic if taken in large enough quantities."

498: 3574: 3215: 3127: 2957: 2846: 2800: 2696: 2581: 2547: 2308: 2190: 2076: 1978: 1820:- the claiming of a new class of anti-depressants is a a bit too much for WP at this point in time. Thanks. 1201: 715: 253:; good responders noticed an added dexterity in cognition, particularly in occupational and social settings 185: 484:

As a result of reading this, I stopped taking the drug and noticed no difference in mood or anything else.

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I have added a section detailing the conditional risk of QT prolongation associated with fluoxetine use.

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https://web.archive.org/web/20070417161229/http://www.ncl.ac.uk/nnp/teaching/management/drugrx/antdep.html

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I was tempted to remove it as unsourced, but as a layman I'll leave that decision to the experts here. --

313: 1913:, for example, is an article written by an MD who is a woman, who describes the condition as a condition. 1471:

post-marketing studies should be required to assess more precisely the severity of these potential risks.

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If you have discovered URLs which were erroneously considered dead by the bot, you can report them with

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If you have discovered URLs which were erroneously considered dead by the bot, you can report them with

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Someone keeps expunging the fact that the NIH has determined that fluoxetine is an acutely toxic drug.

3200:(scroll down to the "Publication types" section), PubMed (now) says this paper is a systematic review. 2676: 2189:. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit 1977:. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit 935: 915: 749: 368: 2347: 2339: 3745: 3648: 3633: 2145: 2101: 1541: 1477: 1170: 1078: 891: 617: 547: 490: 452: 396: 177: 131: 92: 88: 1816:

well, putative PD effect. Even that is seems to just be coming out of his lab. but i can live with

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I recommend that Knowledge ban this editor due to his ignorance, censorship, and abusive behavior.

2708: 2602: 2558: 2525: 2487: 2469: 2412: 2383: 2366: 2346:) 08:15, 2 March 2018 (UTC) In many ways Prozac is to antidepressants as Valium is to anxiolytics. 2127: 1262:

Honestly, do you ever read those tables of generic names? Do you get anything of value out of it?

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Quick note. I dug up the document (on the website of a lawyer who sues drug companies) - it is

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to minority views, even if we might personally like them. So: secondary sources or it stays out.

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No. Not without his claims being reported in credible independent reliable sources, for a start.

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before doing mass systematic removals. This message is updated dynamically through the template

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before doing mass systematic removals. This message is updated dynamically through the template

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http://www.webmd.com/women/pms/news/20000706/fda-approves-prozac-for-treating-severe-form-of-pms

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Toufexis, A. (1993, October 11). The Personality Pill - TIME. Retrieved October 20, 2009, from

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inhibitors'. Neuron Glia Biol. 2010 May;6(2):113-25. Epub 2010 Sep 16. PubMed PMID: 20846463.

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where the text in brackets is determined by the answer to my question above on X065 and HCJE.

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https://web.archive.org/web/20070410122720/http://www.rxlist.com/cgi/generic/fluoxetine_cp.htm

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http://www.benthamdirect.org/pages/content.php?CNSAMC%2F2009%2F00000009%2F00000003%2F0006T.SGM

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useful than in the above cases, because the generic must be EXACTLY identical to the original.

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https://bigthink.com/surprising-science/antidepressants-withdrawal?rebelltitem=3#rebelltitem3

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Can Prozac permanently alter your brain chemistry, wiring, or function, even after you quit?

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I didn't point out that this person ostensibly cannot write English in complete sentences.

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c) It was difficult to find a published study on this. A couple papers and the FDA website

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Nowhere in this article does it say this pharmaceutical drug is used to treat pedophilia.

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or so. The interview from radio including advertising breaks is available as a .mp3 file.

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Ok. Some questions coming up as I'm reading that would impact on the prose we can write:

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Nothing about Carrie Fisher? I feel as though this would be a good thing to put in this.

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http://www.europeanneuropsychopharmacology.com/article/S0924-977X%2814%2900328-9/abstract

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mention an FDA-commissioned meta-analysis matching that description. Eventually I found

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destiny for women? This content is pretty radically POV and it cannot stand as it is.

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to establish the context of what any primary source might say and ensure we do not give

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If you found an error with any archives or the URLs themselves, you can fix them with

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If you found an error with any archives or the URLs themselves, you can fix them with

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in January 2008. I have performed some relatively minor modifications to the section.

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I will wait until they respond, but your position for the moment appears untenable.

2871:. I'd suggest asking for help on how to appropriately word the content you want at 1613: 3460:

Would it be amenable to all those objecting simply to insert a sentence that reads:

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I could find nothing indicating concern about the journal, but it would be nice if

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https://www.health.harvard.edu/sleep/how-sleep-deprivation-can-cause-inflammation

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is a more recent review that also lays out the spectrum between hype and reality.

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http://www.mhra.gov.uk/home/groups/pl-p/documents/websiteresources/con129100.pdf

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If you wish to start a new discussion or revive an old one, please do so on the

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assumption that the drug's half-life is several hours rather than several days.

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https://ahrp.org/prozac-revisited-concerns-about-suicides-surface-boston-globe/

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http://psychiatryonline.org/content.aspx?bookID=28&sectionID=1667485#654260

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with the knowledge that they could very well do so within a matter of minutes.

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Answer: It is what I was diagnosed with and I take it, so yeah I guess it is

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That's simply stating a fact without drawing any toxicological conclusions.

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I want to discontinue using Prozac and never again use ANY antidepressant.

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https://web.archive.org/web/20131108013656/http://pdsp.med.unc.edu/pdsp.php

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anywhere in that reference. I added a citation needed marker in its place.

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The section on discontinuation syndrom has been significantly expanded in

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That solves that then, thanks WAID and Sideswipe9th for the help here.

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What's the unit for the affinities presented in the table? nM, I guess?

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To what double-blind controlled studies does the first sentence refer?

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http://drugtopics.modernmedicine.com/drugtopics/data/articlestandard/

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as fast as an improvement from the day the patients starts taking it.

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shortly to see if I can get the full text of this to check further.

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Caplan, Paula (March 3, 2003). "The Debate About PMDD and Sarafem".

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http://en.wikipedia.org/search/?title=Fluoxetine&oldid=583132940

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Reconcile (a proprietary drug for dogs) in a disambiguation list at

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No. That still has the same problem with PubChem being non-MEDRS.

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the link to PubChem before indicting that person for censorship."

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I've already addressed this. This is a false equivalence fallacy.

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worldwide perspective than the one I am currently writing about.

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http://www.time.com/time/magazine/article/0,9171,979385-1,00.html

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Reference 41 is clearly wrong. Does anybody have the correct one?

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Good point, I will make that correction. Thanks, I missed that.

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body of reliable research papers and other sources it collects.

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http://www.ncl.ac.uk/nnp/teaching/management/drugrx/antdep.html

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a) So far as I can tell, yes, they are the only two mentioned

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link to PubChem before indicting that person for censorship.

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I have right now problem with the following two sentences:

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for additional information. I made the following changes:

1981:

for additional information. I made the following changes:

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https://link.springer.com/book/10.1007/978-1-60327-435-7/

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Thanks for pitching in, Sideswipe9th. You can see from

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edits to the section right there after the statement.

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problems. But we can't talk about root causes can we?

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https://en.wikipedia.org/Drug-induced_QT_prolongation

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Kapit R. FDA Safety Review NDA 18-963, 23 March 1985.

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claims about prozac are contained within interviews,

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https://pubchem.ncbi.nlm.nih.gov/compound/fluoxetine

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International Journal of Risk and Safety in Medicine

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539828/

1480:. That essay, btw, is listed as the first essay in 972:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670606/

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Medical uses: PMDD (Premenstrual Dysphoric Disorder)

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Someone needs to post how this drug is synthesized.

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Does this unsourced statement read like advertising?

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http://www.rxlist.com/cgi/generic/fluoxetine_cp.htm

2037:using the archive tool instructions below. Editors 2953:the full text is available on Gøtzsche's website: 994:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC23979/ 3268:They revert the page as soon as I make the edit. 1176:"An article should not include product pricing 1122:As it is not a dif not sure to what you refer. 2255:This message was posted before February 2018. 2023:This message was posted before February 2018. 2861:carefully, very carefully use primary sources 2667:even serotonin imbalance theory was refuted: 1188:Simple listings without context information." 8: 2988:that PubMed does not consider it a review. 1577:I am moving this here as this appears to be 3066:Dependent on the questions above, and what 2992:knows more about how to use that tool, but 1005:http://cdn.intechopen.com/pdfs-wm/17582.pdf 983:http://www.ncbi.nlm.nih.gov/pubmed/19157982 961:http://cdn.intechopen.com/pdfs-wm/17582.pdf 3256:Chemical vs Medical Toxicity of Fluoxetine 3126:Will incorporate your suggested sentence. 2671:While no one still know how they work... 1076: 3737:heres an abstract section if an article: 3198:https://pubmed.ncbi.nlm.nih.gov/35786661/ 2970:Oh perfect! I will give that a read now! 2181:I have just modified 4 external links on 1969:I have just modified 2 external links on 929:Pharmacodynamics: Neurosteroid modulation 596:radio interview is listed from March 2013 3591:rats. Pharmacol. Rep 69, 830–835 (2017). 1286:Is it a recommended drug for dysthymia? 788:http://www.newsweek.com/id/113121/page/1 561:Removed citation for sexual side effects 3739:https://www.nature.com/articles/nrd1821 1873: 1725:selective brain steroidogenic stimulant 1601: 1433: 1365:reliable, independent secondary sources 1109:2607:FB90:2200:677F:DC1B:6E90:9A58:201A 953: 767: 3566:@2601:6C5:300:B230:B4C2:F17D:A842:B895 3433: 3073: 3044: 2522:Selective serotonin reuptake inhibitor 2437:Fluoxetine can cause QT prolongation: 1453:. Note Kapit's conclusion at the end: 1421: 1264:2601:643:8100:8AF4:C4A2:D991:C7E0:9B17 649:2602:306:C518:6C40:505A:5C79:DCDB:627E 487:I'm inclined to agree with Goldacre. 44:Do not edit the contents of this page. 3734:can someone add a disovery section? 3714:2601:6C5:300:B230:2491:9990:879F:14A5 3605:2601:6C5:300:B230:2491:9990:879F:14A5 3553:2601:6C5:300:B230:B4C2:F17D:A842:B895 3530:2601:6C5:300:B230:B4C2:F17D:A842:B895 3468:2601:6C5:300:B230:B4C2:F17D:A842:B895 3410:2601:6C5:300:B230:B4C2:F17D:A842:B895 3348:2601:6C5:300:B230:B4C2:F17D:A842:B895 3326:2601:6C5:300:B230:B4C2:F17D:A842:B895 3309:2601:6C5:300:B230:B4C2:F17D:A842:B895 3273:2601:6C5:300:B230:B4C2:F17D:A842:B895 1879: 1877: 1607: 1605: 124:place was because of these effects. 7: 2814:It wasn't reverted; it was reworded. 1947:voice. But this content is not OK. 1693:go.galegroup.com.proxy.lib.umich.edu 1465:level, and elevation of serum LDH. 1393:Your statement that "we do not give 3301:That's a false equivalence fallacy. 1652:"The Debate About PMDD and Sarafem" 1514:This article was the subject of an 1036:- used 1 of the reviews you cited. 3166:says that it's a mid-tier journal. 85:http://en.wikipedia.org/Fluoxetine 24: 2185:. Please take a moment to review 1973:. Please take a moment to review 1345:here is summarize controversies. 592:patrick timpone radio one network 355:Edit Request: Mechanism of Action 81:http://en.wikipedia.org/Reconcile 2005:http://pdsp.med.unc.edu/pdsp.php 1618:Women's Studies in Communication 1518:. Further details are available 1507: 1027: 874:Prozac as a personality modifier 581:John Virapen on German wikipedia 29: 2787:Pediatric restoration reversion 1790:really care if we delete that. 1650:Caplan, Paula J. (2004-03-03). 1413:Preposterous interpretation of 3700:the great majority of readers. 2371:05:19, 13 September 2018 (UTC) 1735:there are four reviews on this 1630:10.1080/07491409.2004.10162479 480:The author thinks differently. 318:13:00, 14 September 2010 (UTC) 1: 3722:06:26, 12 February 2023 (UTC) 3613:04:41, 12 February 2023 (UTC) 2865:less so in biomedical content 2655:Prozac Mortal Effects Coverup 2474:14:45, 2 September 2019 (UTC) 2457:13:02, 2 September 2019 (UTC) 2425:02:05, 25 December 2018 (UTC) 2392:06:25, 24 December 2018 (UTC) 2328:Expanding society and culture 1184:"Knowledge articles are not: 1162:15:17, 9 September 2015 (UTC) 1091:14:29, 9 September 2015 (UTC) 1064:08:30, 14 December 2014 (UTC) 944:06:53, 14 December 2014 (UTC) 924:06:59, 14 December 2014 (UTC) 758:06:53, 14 December 2014 (UTC) 705:19:21, 24 November 2013 (UTC) 682:19:21, 24 November 2013 (UTC) 643:How is this drug synthesized? 556:02:04, 27 February 2013 (UTC) 350:18:39, 30 November 2010 (UTC) 3653:18:18, 5 February 2023 (UTC) 3638:18:11, 5 February 2023 (UTC) 3583:06:28, 1 February 2023 (UTC) 3561:05:45, 31 January 2023 (UTC) 3538:04:27, 31 January 2023 (UTC) 3504:03:47, 31 January 2023 (UTC) 3490:03:39, 31 January 2023 (UTC) 3476:03:35, 31 January 2023 (UTC) 3450:03:21, 31 January 2023 (UTC) 3418:03:13, 31 January 2023 (UTC) 3397:02:39, 31 January 2023 (UTC) 3356:02:30, 31 January 2023 (UTC) 3334:02:20, 31 January 2023 (UTC) 3317:02:12, 31 January 2023 (UTC) 3297:01:23, 31 January 2023 (UTC) 3281:01:03, 31 January 2023 (UTC) 3234:05:52, 22 January 2023 (UTC) 3210:04:51, 22 January 2023 (UTC) 3179:17:30, 22 January 2023 (UTC) 3159:12:08, 22 January 2023 (UTC) 3136:08:39, 22 January 2023 (UTC) 3101:00:36, 22 January 2023 (UTC) 3087:00:26, 22 January 2023 (UTC) 3043:On page 19, Gøtzsche states 3030:00:02, 22 January 2023 (UTC) 3011:23:59, 21 January 2023 (UTC) 2980:23:06, 21 January 2023 (UTC) 2966:23:06, 21 January 2023 (UTC) 2946:23:01, 21 January 2023 (UTC) 2912:21:52, 21 January 2023 (UTC) 2890:21:17, 21 January 2023 (UTC) 2859:There are times when we can 2855:20:22, 21 January 2023 (UTC) 2837:19:40, 21 January 2023 (UTC) 2809:19:22, 21 January 2023 (UTC) 2781:17:11, 13 January 2023 (UTC) 2769:16:48, 13 January 2023 (UTC) 2717:11:46, 3 February 2022 (UTC) 2701:11:31, 3 February 2022 (UTC) 2166:02:15, 11 January 2017 (UTC) 2139:23:28, 10 January 2017 (UTC) 2122:18:23, 10 January 2017 (UTC) 1612:Johnson, Davi (2004-10-01). 1556:) 08:49, 16 March 2016 (UTC) 1494:20:46, 19 January 2016 (UTC) 1405:19:11, 19 January 2016 (UTC) 1385:11:44, 13 January 2016 (UTC) 1355:22:11, 12 January 2016 (UTC) 1340:20:50, 12 January 2016 (UTC) 1327:19:45, 10 January 2016 (UTC) 1272:03:03, 18 October 2015 (UTC) 1236:01:15, 18 October 2015 (UTC) 1206:16:48, 17 October 2015 (UTC) 739:22:50, 22 October 2014 (UTC) 724:21:41, 22 October 2014 (UTC) 519:04:48, 30 January 2013 (UTC) 503:04:41, 30 January 2013 (UTC) 373:19:59, 27 January 2011 (UTC) 213:10:22, 23 October 2009 (UTC) 190:02:59, 23 October 2009 (UTC) 169:01:03, 22 October 2009 (UTC) 148:06:24, 20 October 2009 (UTC) 2323:23:29, 2 October 2017 (UTC) 2091:05:43, 2 January 2017 (UTC) 1178:or availability information 327:Part of a recent addition: 113:10:29, 12 August 2009 (UTC) 97:07:10, 12 August 2009 (UTC) 3769: 2534:16:09, 26 March 2021 (UTC) 2512:15:34, 26 March 2021 (UTC) 2496:14:12, 26 March 2021 (UTC) 2286:(last update: 5 June 2024) 2178:Hello fellow Wikipedians, 2054:(last update: 5 June 2024) 1966:Hello fellow Wikipedians, 1957:23:41, 18 April 2016 (UTC) 1775:terminology. is that OK? 1720:03:52, 25 March 2016 (UTC) 1568:02:11, 17 March 2016 (UTC) 1144:23:49, 22 March 2015 (UTC) 1117:14:03, 22 March 2015 (UTC) 637:18:52, 20 April 2013 (UTC) 622:17:47, 20 April 2013 (UTC) 3754:02:12, 9 April 2024 (UTC) 3432:you inserted, which read 2681:18:34, 7 April 2021 (UTC) 2650:11:56, 2 April 2021 (UTC) 2629:20:15, 1 April 2021 (UTC) 2611:17:46, 1 April 2021 (UTC) 2586:17:22, 1 April 2021 (UTC) 2567:15:59, 1 April 2021 (UTC) 2552:15:57, 1 April 2021 (UTC) 2356:08:17, 2 March 2018 (UTC) 1830:07:37, 2 April 2016 (UTC) 1812:07:24, 2 April 2016 (UTC) 1785:06:23, 2 April 2016 (UTC) 1766:22:29, 1 April 2016 (UTC) 1747:22:20, 1 April 2016 (UTC) 576:04:09, 2 April 2013 (UTC) 465:01:05, 15 June 2012 (UTC) 426:12:32, 14 June 2012 (UTC) 409:11:17, 14 June 2012 (UTC) 3196:However, in the case of 1282:Fluoxetine for dysthymia 657:12:25, 26 May 2013 (UTC) 433:I'd just received here. 270:Discontinuation syndrome 2686:Fluoxetine side effects 2174:External links modified 1962:External links modified 1573:Content added per above 251:Sluggishness of thought 3542:According to its site: 2377:Suicide and Fluoxetine 1516:educational assignment 1473: 1467: 1461: 257:Stress and sensitivity 119:Prozac and personality 2994:this is what a review 2642:The Sceptical Chymist 2621:The Sceptical Chymist 2504:The Sceptical Chymist 1894:10.1300/J015v27n03_05 1848:Critiques of Sarafem' 1668:10.1300/J015v27n03_05 1468: 1462: 1456: 205:The Sceptical Chymist 161:The Sceptical Chymist 105:The Sceptical Chymist 42:of past discussions. 3169:That's good enough. 2777:Atomic putty? Rien! 2765:Atomic putty? Rien! 2267:regular verification 2035:regular verification 1859:socially constructed 1844:About this content: 1840:Feminism and Serafem 1293:Pregancy category C? 280:this series of edits 278:in January 2008 and 276:this series of edits 3307:You are censoring. 3144:would be not-RED. 2599:Other canines exist 2257:After February 2018 2025:After February 2018 1886:Women & Therapy 1729:Away back in 2014, 1656:Women & Therapy 1484:itself. anyway.... 843:Ibid., p. 197-222. 825:Ibid., p. 223-249. 662:Unit for affinity ? 245:Pleasure Inhibition 226:Listening to Prozac 219:Personality changes 2401:Fluoxetine#Suicide 2311:InternetArchiveBot 2262:InternetArchiveBot 2079:InternetArchiveBot 2030:InternetArchiveBot 1854:enlightened sexism 1520:on the course page 834:Ibid., p. 67-143. 816:Ibid, p. 223-249. 716:Ex-nimh-researcher 537:Violence and SSRIs 3575:Feline negativity 3216:Feline negativity 3128:Feline negativity 2958:Feline negativity 2869:original research 2847:Feline negativity 2820:original research 2801:Feline negativity 2723:Neuroprotectivity 2287: 2162: 2118: 2055: 1558: 1544:comment added by 1526: 1525: 1383: 1093: 1081:comment added by 903: 894:comment added by 807:Ibid., p. 22-46. 493:comment added by 455:comment added by 399:comment added by 180:comment added by 151: 134:comment added by 72: 71: 54: 53: 48:current talk page 3760: 3431: 3226: 3151: 3071: 3062: 3022: 3003: 2904: 2882: 2829: 2778: 2766: 2409: 2321: 2312: 2285: 2284: 2263: 2214: 2163: 2160: 2156: 2151: 2148: 2119: 2116: 2112: 2107: 2104: 2089: 2080: 2053: 2052: 2031: 1992: 1898: 1897: 1881: 1863:therapeutic drug 1799: 1795: 1703: 1702: 1700: 1699: 1685: 1679: 1678: 1647: 1641: 1640: 1609: 1557: 1538: 1511: 1504: 1441: 1438: 1402: 1377: 1337: 1220: 1128: 1045: 1041: 1035: 1031: 1030: 1018: 1013: 1007: 1002: 996: 991: 985: 980: 974: 969: 963: 958: 889: 866: 861: 855: 850: 844: 841: 835: 832: 826: 823: 817: 814: 808: 805: 799: 796: 790: 784: 778: 772: 606:town hall talks, 505: 467: 411: 192: 150: 128: 68: 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