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Speaking of Opium, what relevance does Opium have to opioids? I am not criticizing the mention of Opium here, I am saying that "opioid" seems to indicate Opium and the article should indicate the relevance or lack of relevance. If opioids are derived from Opium then have the drug companies prevented
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Vardanyan, R.S.; Cain, J.P.; Mowlazadeh
Haghighi, S.; Kumirov, V.K.; McIntosh, M.I.; Sandweiss, A.J.; Porreca, F.; Hruby, V.J. (2017). “Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain” J. Heterocyclic Chem., 54: 1228-1235. doi:
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Opioids are often used in combination with adjuvant analgesics (drugs which have an indirect effect on the pain). In palliative care, opioids are not recommended for sedation or anxiety because experience has found them to be ineffective agents in these roles. Some opioids are relatively
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This appears to be an unsourced assertion rather than fact. Is this even real? More importantly, IMO it is irrelevant and inappropriate for a medical article, without further context. If it were sourced, perhaps it could be included in the "Recreational use" section.
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and derivatives as the second line), incision & drainage of severe abscesses, intraspinal injections, and minor and moderate-impact surgical procedures in patients unable to have general anesthesia due to allergy to some of the drugs involved or other
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Off label use by any given US Doc., is not uncommon - but perhaps focusing on primary indications - as in approved - might be more appropriate for a WP article - perhaps this RLS bit belongs in an article about RLS and not in this art. - Just a thought.
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Evidence supports the use of low dose, regular oral opioids for the safe relief of breathlessness that is not responsive to disease-modifying treatments. This action appears to be a result of the effect on opioid receptors in the limbic system.
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No source is actually provided and some of this is dubious. Is opium actually used clinically?? This subsection was in the "Society and culture' section but includes content that should be in the "Medical use" section, if it were sourced.
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contraindicated in renal failure because of the accumulation of the parent drug or their active metabolites (e.g. codeine and oxycodone). Age (young or old) is not a contraindication to strong opioids. Some synthetic opioids such as
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I noted the RLS debate - and the use of opioids in managing R-RLS - while the editor did give a couple of okay cits., there are MANY other citations that either contradict/challenge the usage or totally refute it.
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Desomorphine is listed as an ester of morphine, in a wrong way in my opinion. Since is a reduction derivative of codeine, it's better to put it in the section of semi-synthetic derivatives.
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I'm not going to prescribe an opiate in this political climate to an RLS patient casually - FL treatment is not an opioid - perhaps pointing that out is impt.
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Other medical uses include suppression of diarrhea, replacement therapy for opioid use disorder, reversing opioid overdose, suppressing cough, as well as for
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Is this yet another attempt by WP to interject politics into an encyclopedia? This from the lead paragraph:
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have metabolites which are actually neurotoxic and should therefore be used only in acute situations.
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101:if needed
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988:contribs
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878:morphine
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381:Medicine
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239:180Â days
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191:Springer
156:Cochrane
69:get help
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642:defunct
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