1436:"In the United States, methamphetamine hydrochloride, under the trade name Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and children; however, the FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent risks associated with its use. To avoid toxicity and a risk of side effects, FDA guidelines recommend the initial dose of methamphetamine at doses 5-10mg/day for the treatment of ADHD in adults, and for the treatment of ADHD and obesity in children over six years of age. If a patient's therapeutic dose has not been reached, the dose may be increased by 5mg in weekly intervals until the optimum clinical response is found. The usual effective dose is around 20-25mg, however some people may find lower doses to be more therapeutic. "Methamphetamine should be administered at the lowest effective dosage, and dosage should be individually adjusted." If required, a daily dose may be divided into 2 effective doses. Methamphetamine is sometimes prescribed off label for narcolepsy and idiopathic hypersomnia in doses up to 60mg. In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products.
2484:
Really? I mean come on lol, I know RLS sucks but people get that from SO many drugs. You do know RLS is mostly correlated with deficient dopamine levels right? Also no offense but virtually everything you said here pretty much goes without saying, itâs kind of just a reiteration of the same stuff people have said for a while now but it still doesnât reconcile how the dependence is not physical. Itâs still physical. We already know the presentation symptoms between these drugs. Like we know dude lol but come on you canât really think that actually changes this issue. We donât have to be experts to discern this. And I would gladly change or look into changing the âpsychological dependenceâ article to a title such as âneurological dependenceâ but the terminology as of now makes no sense and is CLEARLY outdated. And yes credentialed people have pointed this out. But either way itâs a pretty obvious thing. I mean the title and what it implies is like straight out of the 80/90s or something. I even kinda wish there was even room for debate on this topic there really isnât.. Sorry but thereâs just no debatable angles to this. All drug dependencies are physical. Thereâs no way around that.
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drug/âscientificâ/autodidact community in general. It really makes no sense and it treats neurological dependence like something which somehow isnât âphysicalâ merely because the symptoms are not somatic. The symptoms may not be âphysicalâ but the dependency itself certainly is. Even coffee causes physical/neurological dependence. It seems to just be harping on the grossly outdated idea that stimulant dependencies are âfictiveâ or just âin your headâ with no palpable mechanisms which is clearly not the case. Meanwhile we have the other extreme going on with the cocaine article where people keep insisting on putting âhigh physical dependenceâ propensity which seems just as senseless. I canât see any justifications for the meth/cocaine articles saying anything other than âmoderateâ in regards to the physical dependence sections. Maybe moderate - high at most. But just shamelessly saying straight up âhighâ or ânoneâ is pretty ridiculous and essentially impossible to justify.
1425:"In the United States, methamphetamine hydrochloride, under the trade name Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and children; however, the FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent risks associated with its use. To avoid toxicity, FDA guidelines recommend methamphetamine at doses 25mg/day for ADHD in adults and children over six years of age. Methamphetamine is sometimes prescribed off label for narcolepsy and idiopathic hypersomnia. In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products."
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Methamphetamine is a direct neurotoxin to DA neurons and current reviews of neuroimaging studies show that methamphetamine use correlates with neurotoxicity/neurodegeneration. Obviously, given (1) the common dosage patterns amongst methamphetamine users worldwide and (2) how irrelevant
Desoxyn is relative to other USFDA-approved ADHD psychostimulants, meth use correlates with high-dose meth use in general. So, again, methamphetamine is clearly directly toxic at higher doses in humans, but that finding cannot be extended to lower (i.e., ~25 mg) doses.
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1495:"For treatment of children 6 years or older with a behavioral syndrome characterized by moderate to severe distractibility, short attention span, hyperactivity, emotional lability and impulsivity: an initial dose of 5 mg DESOXYN once or twice a day is recommended. Daily dosage may be raised in increments of 5 mg at weekly intervals until an optimum clinical response is achieved. The usual effective dose is 20 to 25 mg daily. The total daily dose may be given in two divided doses daily."
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1719:. I know I've read this in a handful of sources before, so it shouldn't be difficult to cite. If a comparison between amphetamine and methamphetamine enantiomers is included at all, then all 4 should probably be mentioned. Otherwise, I think cutting it seems justified. Also, while levomethamphetamine technically is a CNS stimulant, it's a fairly weak one in comparison to the other enantiomers, particularly considering that it's sold OTC in the United States as a nasal decongestant.
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transport chain enzyme subunits. I think it's also worth pointing out that any neurotoxicity is also potentiated by meth's activity at Sigma 1&2 receptors in human DA neurons, which increases DA release and elevates body temperature (NB activation of sigma receptors aren't inherently neurotoxic, but they potentiate meth's neurotoxicity because of several
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969.7 (psychostimulant poisoning) or E854.2 The study was based on a review of hospital records, so the doses used cannot be determined. People admitted into the study had to have been medically treated for either dependance, abuse or poisoning related to stimulants. What do you think the low dose vs high dose breakdown is for each of those categories?
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2984:. A UK study, zero meth use. All Amphetamine for the stimulant users. All amphetamine users took street amphetamine daily; 7 were also receiving a dextroamphetamine prescription (dose36.421.9 mg); none reported methamphetamine use. I'm not sure why the authors cited this. They do know that amphetamine and methamphetamine are different drugs right?
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3184:, I owe you an apology. I distinctly remmeber adding that line to the source code, but, I've just checked the revision history for this article and there's no update from me on the 28th. So, I assume I simply forgot to click publish afterwards because of sleep deprivation and/or my medication having worn off. My bad.
2964:", but never quantify the "low dose" part of the title. Maybe there was some confusion during editing and that sentence got cut? They must have got that from somewhere though, so I read the cited papers and see to see what dose is considered low dose methamphetamine. There are eight papers cited in the section,
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Is there anymore evidence that asserts that methamphetamine is toxic at low doses? I understand that there's going to be a greater prevalence of evidence covering high-dose users because methamphetamine is primarily a recreationally used drug. But, surely there needs to be some direct coverage of low
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Not low doses. The minimum dose to be admitted into the study is at least 5-10 times the therapeutic dose range. "METH abusers fulfilled
Diagnostic and Statistical Manual of Mental Disorders IV criteria for METH dependence (average METH use of at least 0.25 gm /d, at least 5 d per week for at least 2
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Uhm... I'm pretty sure if the racemate is common name, then the dextro and levo enantiomers have the same common name. If you want to make a big fucking deal about this and draw other editors in simply because you don't like being reverted, then we can go back through the motions all over again. But,
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This is misleading, considering that a beginning dose, 25mg of methamphetamine, is NOT recommended by the FDA for the treatment of ADHD in adults, as well as the treatment of ADHD and obesity in children over six years of age without an observed clinical trial. A dose of 25mg is only "recommended" in
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Anyway, I was looking through the citations to better understand how and why methamphetamine is neurotoxic even at the doses indicated for ADHD, because they aren't as direct and straight forward as the imaging meta-analysis on ADHD amphetamine use in that article. I found two citations that seem to
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In the United States, methamphetamine hydrochloride, under the trade name
Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and children; however, the FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent
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In the United States, methamphetamine hydrochloride, under the trade name
Desoxyn, has been approved by the FDA for treating ADHD and obesity in both adults and children; however, the FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent
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for this to occur. Increases of sufficiently high DA via meth's participation in TAAR1- and CAMKII-mediated signaling cascades that phosphorylate DAT - and subsequent DA autoxidation can definitely amplify the neurotoxic effects of meth due DA quinones also having the capacity to mess with electron
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which allows it to permeate mitochondria in DA neurons and inhibit complexes II and III of the electron transport chain to trigger mitochondria depolarisation. Inhibition of those complexes from sufficient concentration of methamphetamine disrupts oxidative phosphorylation and ATP production (i.e.,
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Individuals aged at least 50 years were assigned to the methamphetamine group only if they had the following characteristics: (1) an ICD-9 diagnosis, in any diagnostic position, of 304.4 (amphetamine and other psychostimulant dependence), 305.7 (amphetamine or related acting sympathomimetic abuse),
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Also not that it really matters and itâs certainly not a competition but.. Those âopioid withdrawal symptomsâ you listed sound like some pretty rookie shit to me. Iâve had weed withdrawals that make those symptoms you listed look like a freaking trip to
Disneyland. And I mean restless leg syndrome?
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itself is still clearly physical. I donât understand why people have such a problem accepting that drug dependencies are either neurological or somatic (or even both) but thereâs literally still no such thing as a ânon-physical drug dependencyâ. Thatâs a pretty contradictory notion. I mean somebody
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Well I donât see what that link has to do with dependence since that word isnât even mentioned, nor do I see how itâs even a remotely reputable source. I bet I could scour that site and find dozens of bits of misinformation. Iâve found worse from âbetter sitesâ after all. At the end of the day many
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As a convention, most substituted amphetamines that are also prescription drugs don't use the INN, as is evident from the tracking category entries below. Their INNs are much less recognizable than the names derived from the amphetamine contraction (i.e., the common names that are used instead) in
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Accidentally said levoamphetamine instead of levomethamphetamine in my edit summary but I still donât see how itâs relevant, particularly right there. Seems pretty random and I donât see the point of comparing an isomer of methamphetamine to one of amphetamine when itâs not even comparing the same
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at doses 5-10mg/day for ADHD in adults and children over six years of age, and may be increased at weekly intervals of 5mg, up to 25mg/day, until optimum clinical response is found; the usual effective dose is around 20-25mg/day. Methamphetamine is sometimes prescribed off label for narcolepsy and
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at doses 5-10mg/day for ADHD in adults and children over six years of age, and may be increased at weekly intervals of 5mg, up to 25mg/day, until optimum clinical response is found; the usual effective dose is around 20-25mg/day. Methamphetamine is sometimes prescribed off label for narcolepsy and
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I was debating whether I should've included that
Desoxyn can be prescribed for Narcolepsy at up to 60mg, but I later realized that it was unnecessary to include the maximum dosages because the clinical period is probably the same for somebody being prescribed methamphetamine for narcolepsy. Thanks
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Reference states that, "Methamphetamine is used as a secondary treatment for attention deficit hyperactivity disorder (ADHD) in children over the age of six and for the short-term management of exogenous obesity. Used in this context, the FDA has approved the administration of methamphetamine at
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This article refers to methamphetamine as a neurotoxin, aka a direct neurotoxin. Before I continue, I just want to state that it's very clear that methamphetamine will induce neurodegeneration with chronic exposure to high doses. Not only is this evident from the generous amount of brain imaging
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Oh hey, a rat study. "The next day, rats received 4 injections at 2-hr intervals of either 0.9% saline or METH (10 mg/kg, s.c.). The rats were repeatedly injected with high doses (the LD50 of meth for rats is ~50mg/kg)." So after reading every single citation in the section, the lowest dose
2393:", per the lead of that article. All of those symptoms reflect a withdrawal syndrome associated with physical dependence. The symptoms I didn't quote from the lead - given that they're cognitive in nature - reflect psychological dependence. That being said, I don't see where in this article or
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Also while Iâm here, is there actually a source that says methamphetamine hydrochloride (HCl) is the crystallized form of methamphetamine because that sounds sort of contradictory to me but maybe I just donât know enough about chemistry. I thought hydrochloric salts were literally removed from
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No mention of dose - Users recruited into the study came from treatment programs. MA and COC using participants were recruited from people treatment clinics in San
Bernardino and Los Angeles counties in California. All of the participants for either drug group met DSM-IV criteria for abuse or
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In any event, all direct neurotoxins have a threshold dose they must meet in order to exert their relative toxic effect on the brain. What makes them direct neurotoxins is the fact that the substance engages in a direct pharmacological interaction with some aspect of a neuron that results in
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With all that said, I doubt we're going to get a clear answer on whether methamphetamine is neurotoxic or neuroprotective at the USFDA-approved dose range for
Desoxyn pharmaceuticals through meta-analytic reviews of neuroimaging studies of low-dose users, a la amphetamine, any time soon.
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there's virtually no way you're going to convince everyone to keep the INN of that page the way it is given previous discussions about these article names. Also, using an INN for an enantiomer and a different common name for the racemate in their respective articles is just weird.
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Admittedly Iâm not sure on that one about the hydrochloride form but I do know for a fact that physical dependence saying ânoneâ is undoubtedly incorrect. This notion that only downers cause genuine physical dependencies is getting pretty old. Not just on
Knowledge but in the
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As for the revised wording RE: meth nTox across the 2nd and 3rd editions of the
Molecular Neuropharamcology textbook, that likely happened as a result of increasing questions of whether methamphetamine at lower doses is actually toxic to DA neurons, especially in humans.
1852:. The exceptions to using the INN and when to use a different common name as the pagename is explicitly stated on the MOS page, and the particular exceptions for methamphetamine and several amphetamine derivatives are stated as examples on the MOS page as well. To quote
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People think âpsychological dependenceâ means a fictive craving or just a mental desire. They donât realize that it has neurological foundations and if they did they would admit that itâs physical, which it is. This is one of the things thatâs not debatable.
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I'm not Seppi, but I feel the need to point that this article doesn't actually quantify the threshold exposure (i.e., dose) of methamphetamine that's necessary for DA neurotoxicity. The only mention of dose "range" is in the lead with the statement that
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mentioned is 250mg a day. I don't think anyone could call that a "low dose". I have no idea why the section was named the way it was when there is zero evidence to support it. It's unfortunate that seems to have confused a number of individuals.
2990:. The present study was designed to further our understanding of changes in brain function in humans that might result from chronic high dose use of MA after at least 3 months of abstinence. The study specifically recruited high dose users.
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talk page archives and search for discussions about "INN" if you want to read the discussion about the use of the INN as the pagename and exceptions to this rule, but that's a bit unnecessary given what's actually written on
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s that they interact with; sigma-2 receptor activation can also trigger apoptotic cascades). That being said, the biggest contributor to neurodegeneration when using methamphetamine at relatively high doses is cerebral
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the occurrence of physical dependence is mentioned. They shouldn't state this because neither one - nor virtually any other psychostimulant drug - induces physical/somatic withdrawal symptoms after repeated use.
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Where is the arbitration or discussion that determined this should be the case? I checked the Manuals of Style, but couldnât find such a supposed exception. If you could let me know, that would be appreciated.
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studies avaliable on meth recreational (high) and binge (very high) users, but also from the neurotoxic mechanisms methamphetamine has at high doses via EAAT inhibition and hyperthermia/BBB permeability.
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Based on autopsies, 11 out of 16 were reported to have methamphetamine intoxication as cause of death. I think we can all agree that a lethal dose of methamphetamine would not be considered a "low" dose?.
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mitochondrial dysfunction) which confers increased susceptibility to apoptosis. This is a direct pharmacological effect of the methamphetamine molecule in DA neurons and DA neurotransmission is not
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https://www.researchgate.net/publication/232545123_Comparative_Epidemiology_of_Dependence_on_Tobacco_Alcohol_Controlled_Substances_and_Inhalants_Basic_Findings_From_the_National_Comorbidity_Survey
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certain drugs (such as cocaine) to make them âsmokableâ (unless itâs a case by case thing), and from what I understand crystallized methamphetamine was first introduced specifically to be smoked.
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for the content in the destination pages and must not be deleted as long as the copies exist. For attribution and to access older versions of the copied text, please see the history links below.
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criteria. If you want to disseminate your personal opinion, you should do that in your own blog or somewhere else, and not infiltrate into every medical article pushing your personal opinion. --
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contains an updated list of of articles that don't follow this article title guideline and include the INN in the drugbox INN parameter; these articles are listed under the underscore section.
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a particular drug, I made that change, the CDC implies that these numbers represent the number of deaths with a particular drug, at least with opiates. See Understanding the Opiate Epidemic.
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1795:. Just wanted to give you advance notice that I'll swap back the pagenames sometime in the near future. Since the page has fairly low traffic, this isn't a matter of any particular urgency.
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Apologies in advanced for any grammatical errors; I finished writing this some time after my medication wore off and I pretty much lost all interest in proof reading by the end of it.
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Meanwhile, studies show Methamphetamine to have moderate addiction potential, 10-15%, which is the same addiction liability as Alcohol which has âModerate (10-15%)â on its wiki page.
3026:, as they've been very active throughout this article over the years. Given the scope of contributions you've made here, I trust you wouldn't have made such an assertion lightly.
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be the most relevant for claims of low dose/direct neurotoxicity. The first one is" Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.)" which states
2265:. I mean, one of those is an FA and this page is a GA. Obviously, the pagenames have been discussed ad nauseum. I just don't remember if they primarily took place on this page,
2381:- the more general concept - can entail either or both, depending on the drug. Physical/somatic withdrawal symptoms are easily observable/measurable. E.g., ethanol can induce
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2978:. The subjects were included in the study if their average methamphetamine use involved at least 0.5 g/day, at least 5 days per week,for at least 2 years. No low doses here
2747:, not just methamphetamine. This nuance should be included if we write a section on overdose deaths. It should be tailored to incidents of only methamphetamine overdose. --
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want to read the relevant discussions, I'll link them for you later tonight or tomorrow. But again, I don't really see why you find it necessary given the fact that for
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Not trying to be a dick, but you need to understand there has been a lot of discussion about these article names in the past. It's not like MOS:PHARM is just ignored on
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Hmm. I tend to agree; that seems like a weird comparison without additional context, especially given that it's in the lead. Ranked by psychostimulant potency, it's:
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Granted, this kind of feels contradictory. If something is directly toxic, surely it should cause toxicity upon exposure. Say, if a 5mg Desoxyn tablet were given.
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2596:"Super meth" and "P2P meth" are getting a lot of discussion in the popular press lately but are not mentioned here. Could someone please add some information?
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dose/therapeutic dose range to be stating outright that methamphetamine is directly neurotoxic in the article. I feel like if anyone would know, it would be @
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Secondly, the source "Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology". has a section in the paper titled "
2455:âprofessionalsâ donât even care about the details or the technical nuances, theyâre just doing a job and want to finish and get home like everybody else.
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idiopathic hypersomnia. In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products.
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idiopathic hypersomnia. In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products.
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2960:" That seems very direct. However, reading the content of the section, they don't quantify dose. They mention damage related to "chronic use" and "meth
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There is no evidence that Methamphetamine addiction potential is âvery highâ, and there is no source linked to back up that claim on this page.
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to be written into a project MOS, it has to be discussed ad nauseum on the talk page first. So, you already know you'll find a consensus there.
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I appreciate you being proactive about moving pages on drug articles to their INN pagename. There are, however, a handful of exceptions to the
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yeah that makes no sense because obviously the mechanisms which cause psychological symptoms are still very physical regardless, therefore the
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I think that information would be very useful for readers, so I think it should be included.Another editor recently moved the page
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type of isomer. Comparing potency of dextroamphetamine to dexromethamphetamine would make exponentially more sense (in the intro).
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I suggest that we revise the Medical section of methamphetamine to become more informative and to ensure maximum risk prevention.
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reliasmedia.com, nchrc.org, amegroups.org, consultant360.com, and chooser.crossref.org are not reliable sources.Interpreting
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If you want to conflate the two, thatâs your prerogative. Everyone else in the world is still going to make the distinction.
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naming convention on drugs (see the first note), and you incidentally happened to come across one of those exceptions with
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methamphetamine is neurotoxic to human midbrain dopamine neurons and, to a lesser extent, serotonin neurons at high doses.
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English-speaking countries. As a rather extreme example, I doubt even 1% of the general population would even recognize
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It might be that opiates are perceived to be more lethal than methamphetamine or cocaine which is probably true.
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FDA guidelines recommend methamphetamine at doses 25mg/day for ADHD in adults and children over six years of age.
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dependence. I think it's safe to assume that most users in treatment for addiction were not low dose users.
2364:. Pure, unadulterated methamphetamine hydrochloride looks like a translucent white crystal, hence the name.
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To avoid toxicity and risk of side effects, FDA guidelines recommend an initial dose of methamphetamine
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This is the image we use to illustrate methamphetamine hydrochloride (crystal meth). Compare this to
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the treatment of ADHD (Or a child's obesity) after testing a patient's dose-responsive relationship.
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Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers
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To avoid toxicity and risk of side effects, FDA guidelines recommend initial dose of methamphetamine
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It doesn't matter what your opinion is. Knowledge articles are based on reliable sources that meet
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on Knowledge. If you would like to participate, please visit the project page, where you can join
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on Knowledge. If you would like to participate, please visit the project page, where you can join
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on Knowledge. If you would like to participate, please visit the project page, where you can join
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Hmmm... it seems that the category is still missing actually. Would you mind checking it again,
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Whereâs this supposed âbig fucking dealâ youâre whining about? I was nothing but polite to you.
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Text has been copied to or from this article; see the list below. The source pages now serve to
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Thatâs methamphetamine, racemic, not enantiopure levmetamfetamine which is being referred to.
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Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence.
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Incidence of Parkinsonâs disease among hospital patients with methamphetamine-use disorders.
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dependence is ALWAYS physical and thatâs an inescapable fact. So this is clearly a misnomer.
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Stated within the Desoxyn Prescribing Information PDF, reference 24, and according to "",
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Here is a link to one such study that shows Methamphetamineâs 10-15% addiction liability:
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is literally just based on whether withdrawal symptoms are physical/somatic or cognitive.
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I also like how you improved the readability of the edit through the use of semicolons.
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Methamphetamine overdose deaths often involves polydrug abuse, involving various drug
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Hello. Requesting that the following category be added to this semi-protected page:
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Drugbox tracking category entries for pages that don't use their INN as the pagename
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However, I have read the third edition from 2015, which has revised this claim to
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can say what they want about the symptoms themselves but the dependence.. like the
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Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
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restless legs, nausea, vomiting, diarrhea, sweating, and an increased heart rate
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True, but I wouldn't expect to be immediately reverted by someone non-combative.
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This information should also be added to the pharmacology section on the page.
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Everyone else in the world? Nobody believes neurological doesnât mean physical
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However, I have read the third edition from 2015, which has revised this claim
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This section is well reference by many reliable sources including the CDC.
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This article needs mentions and definitions of "super meth" and "P2P meth"
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Perseverative behavior in rats with methamphetamine-induced neurotoxicity.
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toxicity. Methamphetamine is a direct neurotoxin if only due its high
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I appreciate the quick fix. Thanks for updating my talk page as well!
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Cognitive Performance of Current Methamphetamine and Cocaine Abusers
2941:"Unlike cocaine and amphetamine, methamphetamine is directly toxic
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1096:, a collaborative effort to improve the coverage of all aspects of
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Change âAddiction liabilityâ from Very High to Moderate (10-15%).
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History_and_culture_of_substituted_amphetamines#Illegal_synthesis
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Anyway, I've rectified this in the latest revision of the page.
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Knowledge level-5 vital articles in Biology and health sciences
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Methamphetamine Hcl =\= Crystal meth? Also physical dependence
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Dextroamphetamine stronger stimulant than levomethamphetamine
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Reflection Impulsivity in Current and Former Substance Users
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for Knowledge's health content are defined in the guideline
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Brain serotonin transporter in human methamphetamine users
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and that when it is smoked it causes a massive release of
3051:" This is entirely consistent with the sources mentioned.
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Knowledge:WikiProject Psychoactive and Recreational Drugs
651:. To participate, help improve this article or visit the
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2882:: Methamphetamine have established addiction liability.
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sources (such as stats, invidual case reports, etc.) is
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Template:WikiProject Psychoactive and Recreational Drugs
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Thank you for your help. That is greatly appreciated.
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736:, a collaborative effort to improve the coverage of
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clinical publications about evidence-based medicine
2775:Although these statistics are reported as deaths
1858:A drug article should be titled according to its
1243:Knowledge:Identifying reliable sources (medicine)
495:A fact from this article appeared on Knowledge's
2781:https://www.cdc.gov/opioids/basics/epidemic.html
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2915:Methamphetamine "direct" neurotoxicity validity
1366:History and culture of substituted amphetamines
1343:History and culture of substituted amphetamines
1025:WikiProject Psychoactive and Recreational Drugs
845:and that biomedical information in any article
2671:. Overdose information should be sourced from
1557:for catching that and shortening up the edit!
371:If it no longer meets these criteria, you can
843:Manual of Style for medicine-related articles
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3010:years, at least2 weeks of METH abstinence).:
1045:Psychoactive and Recreational Drugs articles
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1090:This article is within the scope of
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2958:2.2. Long-Term Damage of Low Dose
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1843:I mean ... you could check the
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2947:to midbrain dopamine neurons."
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1962:3,4-Methylenedioxyamphetamine
1854:MOS:PHARM#Articles to use INN
1789:MOS:PHARM#Articles to use INN
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864:Template:WikiProject Medicine
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3197:10:21, 19 August 2024 (UTC)
3176:19:27, 17 August 2024 (UTC)
3104:Protected page edit request
2831:to reactivate your request.
2819:has been answered. Set the
2012:Copper (64Cu) oxodotreotide
1889:Notable exceptions include
1714:dextromethamphetamine : -->
1605:to reactivate your request.
1593:has been answered. Set the
1489:doses of up to 25 mg/day."
1411:to reactivate your request.
1399:has been answered. Set the
1117:Template:WikiProject Autism
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516:The text of the entry was:
63:New to Knowledge? Welcome!
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3298:GA-Class medicine articles
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3144:Professional Crastination
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2884:Methamphetamine#Addictive
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2017:CureVac COVID-19 vaccine
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362:good article criteria
259:Auto-archiving period
136:Find medical sources:
113:Neutral point of view
2142:Tetrahydrocannabinol
2047:Imidazole salicylate
1967:4-Hydroxyamphetamine
1866:is more appropriate.
1274:free review articles
1250:. Here are links to
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1165:
1160:
1148:
1147:
1144:
1143:
1132:
1126:
1125:
1123:
1106:the discussion
1088:
1076:
1075:
1067:
1055:
1054:
1051:
1050:
1048:
1021:
1009:
1008:
996:
984:
983:
980:
979:
972:Mid-importance
968:
962:
961:
959:
942:the discussion
928:
916:
915:
913:Midâimportance
907:
895:
894:
891:
890:
879:
873:
872:
870:
834:
833:
817:
805:
804:
796:
784:
783:
780:
779:
768:
762:
761:
759:
742:the discussion
728:
716:
715:
707:
695:
694:
691:
690:
679:
673:
672:
670:
629:
617:
616:
608:
596:
595:
589:
567:
553:
552:
549:
548:
541:
540:
515:
489:
488:
485:
484:
481:
474:
466:
465:
462:
455:
447:
446:
443:
436:
428:
427:
424:
417:
409:
408:
405:
402:
398:
397:
382:
381:
347:
335:
334:
300:
288:
287:
278:
276:
275:
272:
271:
217:
216:
131:
130:
126:
125:
120:
115:
106:
105:
103:
102:
95:
90:
81:
75:
73:
72:
61:
52:
51:
48:
47:
41:
25:
24:
19:
13:
10:
9:
6:
4:
3:
2:
3355:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3215:
3213:
3198:
3194:
3190:
3186:
3183:
3182:174.66.87.253
3179:
3178:
3177:
3173:
3169:
3168:174.66.87.253
3166:? Thank you.
3165:
3161:
3160:
3159:
3158:
3157:
3156:
3153:
3149:
3145:
3141:
3132:
3131:
3130:
3129:
3125:
3121:
3117:
3109:
3103:
3099:
3095:
3091:
3086:
3084:hyperpyrexia.
3082:
3077:
3072:
3071:lipophilicity
3067:
3064:
3059:
3057:
3053:
3050:
3045:
3042:
3041:
3040:
3039:
3035:
3031:
3027:
3025:
3015:
3012:
3008:
3005:
3002:
2999:
2995:
2992:
2989:
2986:
2983:
2980:
2977:
2974:
2970:
2967:
2966:
2965:
2963:
2959:
2953:
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2949:
2948:
2945:
2936:
2932:
2931:
2930:
2925:
2921:
2914:
2910:
2906:
2900:
2897:
2896:
2891:
2885:
2880:
2871:
2870:
2869:
2868:
2864:
2860:
2855:
2854:
2850:
2847:
2844:
2841:
2838:
2830:
2827:parameter to
2818:
2814:
2807:
2806:
2800:
2796:
2792:
2788:
2784:
2782:
2778:
2774:
2773:
2772:
2771:
2767:
2761:
2758:
2757:
2752:
2746:
2741:
2740:
2736:
2732:
2727:
2717:
2713:
2709:
2705:
2704:
2703:
2699:
2693:
2690:
2689:
2684:
2678:
2674:
2670:
2666:
2662:
2661:
2660:
2659:
2655:
2651:
2643:
2639:
2635:
2629:
2626:
2625:
2620:
2614:
2610:
2609:
2608:
2607:
2603:
2599:
2591:
2581:
2577:
2571:
2568:
2567:
2562:
2556:
2552:
2551:
2550:
2546:
2542:
2537:
2535:
2531:
2527:
2523:
2522:
2521:
2517:
2516:
2510:
2509:
2508:
2497:
2496:
2495:
2491:
2487:
2482:
2479:
2474:
2470:
2466:
2462:
2458:
2453:
2452:
2451:
2447:
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2440:
2439:
2438:
2427:
2423:
2421:
2417:
2416:
2410:
2409:
2408:
2396:
2392:
2388:
2384:
2380:
2376:
2372:
2368:
2367:
2363:
2358:
2354:
2353:
2349:
2345:
2339:
2332:
2312:
2308:
2307:
2301:
2300:
2299:
2288:
2284:
2280:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2248:
2245:
2244:
2243:
2239:
2235:
2231:
2230:
2229:
2225:
2224:
2218:
2217:
2216:
2204:
2203:
2202:
2198:
2194:
2190:
2189:
2188:
2184:
2183:
2177:
2176:
2175:
2165:
2164:
2163:
2162:
2161:
2160:
2159:
2158:
2157:
2156:
2148:
2145:
2143:
2140:
2138:
2135:
2133:
2130:
2128:
2125:
2123:
2120:
2118:
2115:
2113:
2110:
2108:
2105:
2103:
2100:
2098:
2095:
2093:
2090:
2088:
2085:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2055:
2053:
2050:
2048:
2045:
2043:
2040:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2000:
1998:
1995:
1993:
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1973:
1970:
1968:
1965:
1963:
1960:
1959:
1958:
1957:
1950:
1935:
1930:
1929:
1928:
1927:
1926:
1925:
1924:
1923:
1922:
1921:
1915:
1913:
1908:
1907:tenamfetamine
1904:
1900:
1899:metamfetamine
1896:
1892:
1885:
1882:
1867:
1865:
1861:
1855:
1851:
1846:
1840:
1835:
1834:
1833:
1829:
1825:
1820:
1819:
1818:
1814:
1813:
1807:
1806:
1805:
1794:
1790:
1784:
1779:
1778:
1777:
1773:
1767:
1764:
1763:
1758:
1752:
1748:
1744:
1743:
1742:
1738:
1737:
1731:
1730:
1729:
1711:
1710:
1709:
1708:
1704:
1700:
1691:
1687:
1681:
1679:
1672:
1670:
1662:
1653:
1652:
1651:
1650:
1646:
1642:
1637:
1632:
1628:
1625:
1620:
1616:
1615:
1613:
1604:
1601:parameter to
1592:
1588:
1581:
1580:
1574:
1568:
1564:
1560:
1555:
1552:
1549:
1548:
1547:
1543:
1537:
1534:
1533:
1528:
1521:
1512:
1511:
1510:
1509:
1505:
1501:
1496:
1493:
1490:
1486:
1482:
1480:
1476:
1472:
1466:
1465:
1463:
1453:
1448:
1445:
1441:
1437:
1434:
1433:
1430:
1426:
1423:
1422:
1419:
1410:
1407:parameter to
1398:
1394:
1387:
1386:
1380:
1371:
1367:
1363:
1359:
1355:
1351:
1348:
1344:
1340:
1336:
1332:
1328:
1327:
1325:
1321:
1314:
1313:
1304:
1303:
1298:
1297:
1292:
1289:
1288:
1283:
1282:TRIP database
1279:
1276:
1275:
1270:
1269:
1264:
1261:
1260:
1257:
1253:
1249:
1245:
1244:
1239:
1238:Ideal sources
1236:
1233:
1229:
1228:
1213:
1196:
1192:
1188:
1187:
1182:
1179:
1176:
1172:
1171:
1167:
1164:
1161:
1158:
1154:
1141:
1137:
1131:
1128:
1127:
1124:
1107:
1103:
1099:
1095:
1094:
1089:
1086:
1082:
1081:
1077:
1071:
1068:
1065:
1061:
1049:
1032:
1031:
1026:
1022:
1019:
1015:
1014:
1010:
1005:
1000:
997:
994:
990:
977:
973:
967:
964:
963:
960:
943:
939:
935:
934:
929:
926:
922:
921:
917:
911:
908:
905:
901:
888:
884:
878:
875:
874:
871:
854:
853:
848:
844:
840:
839:
831:
820:
818:
815:
811:
810:
806:
800:
797:
794:
790:
777:
773:
767:
764:
763:
760:
743:
739:
735:
734:
729:
726:
722:
721:
717:
711:
708:
705:
701:
688:
684:
678:
675:
674:
671:
654:
650:
649:
644:
643:
638:
637:
636:
630:
627:
623:
622:
618:
612:
609:
606:
602:
597:
593:
587:
579:
578:
568:
559:
558:
547:
542:
537:
535:
531:
527:
523:
522:
512:
511:
506:
504:
503:Did you know?
498:
493:
486:
482:
480:
479:
475:
472:
468:
467:
463:
461:
460:
456:
453:
449:
448:
444:
442:
441:
437:
434:
430:
429:
425:
423:
422:
418:
415:
411:
410:
406:
403:
400:
399:
393:
387:
383:
378:
376:
375:
367:
363:
359:
358:
357:
351:
348:
345:
341:
340:
332:
328:
324:
320:
316:
312:
308:
307:
301:
298:
294:
293:
274:
273:
268:
264:
256:
252:
248:
244:
240:
236:
232:
228:
225:
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218:
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209:
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199:
195:
192:
189:
186:
185:ScienceDirect
183:
180:
177:
173:
169:
165:
161:
157:
153:
150:
147:
143:
137:
133:
132:
124:
123:Verifiability
121:
119:
116:
114:
111:
110:
109:
100:
96:
94:
91:
89:
85:
82:
80:
77:
76:
70:
66:
65:Learn to edit
62:
59:
54:
53:
50:
49:
45:
39:
35:
31:
30:
23:
20:
18:
17:
3139:
3113:
3107:
3062:
3028:
3020:
3013:
3006:
3000:
2993:
2987:
2981:
2975:
2968:
2961:
2957:
2954:
2951:
2943:
2940:
2939:
2937:
2933:
2928:
2927:
2926:
2922:
2918:
2894:
2893:
2889:
2878:
2859:24.5.117.157
2856:
2851:
2848:
2845:
2842:
2839:
2836:
2828:
2817:edit request
2787:Reknihtdivad
2776:
2755:
2754:
2750:
2744:
2742:
2731:Reknihtdivad
2722:
2708:Reknihtdivad
2687:
2686:
2682:
2679:criteria. --
2673:WP:SECONDARY
2650:Reknihtdivad
2647:
2623:
2622:
2618:
2595:
2565:
2564:
2560:
2514:
2504:
2500:
2477:
2472:
2444:
2434:
2430:
2414:
2404:
2400:
2340:
2336:
2305:
2295:
2291:
2286:
2282:
2222:
2212:
2208:
2181:
2171:
2167:
2057:Isoprenaline
2037:Fenethylline
1992:Blarcamesine
1884:
1811:
1801:
1797:
1761:
1760:
1756:
1735:
1725:
1721:
1695:
1678:open channel
1677:
1668:
1660:
1635:
1630:
1629:
1623:
1618:
1617:
1614:
1611:
1610:
1602:
1591:edit request
1531:
1530:
1526:
1519:
1497:
1494:
1491:
1487:
1483:
1478:
1474:
1470:
1467:
1464:
1461:
1460:
1447:
1439:
1435:
1431:
1429:To Change B:
1428:
1427:
1424:
1420:
1417:
1416:
1408:
1397:edit request
1300:
1294:
1285:
1272:
1266:
1255:
1251:
1241:
1237:
1191:project page
1184:
1180:
1135:
1091:
1028:
971:
947:Neuroscience
938:Neuroscience
931:
910:Neuroscience
882:
850:
836:
771:
747:Pharmacology
738:Pharmacology
731:
710:Pharmacology
682:
653:project page
646:
640:
633:
632:
592:WikiProjects
575:
546:Good article
545:
519:
517:
508:
500:
476:
457:
438:
426:Not promoted
419:
372:
370:
366:please do so
354:
353:
349:
318:
314:
310:
303:
262:
220:
207:
201:
193:
187:
181:
175:
167:
159:
151:
145:
135:
107:
32:This is the
2857:Thank you.
2251:amphetamine
2092:Methicillin
2042:Gosogliptin
1977:Amphetamine
1936:by its INN.
1903:diamorphine
1864:common name
1856:directly: "
440:Peer review
304:written in
44:not a forum
3212:Categories
2821:|answered=
2665:WP:PRIMARY
2473:dependence
2424:Addendum:
2389:involves "
2132:Tenilapine
2082:Merestinib
2022:Cysteamine
1895:amfetamine
1669:FlightTime
1595:|answered=
1440:References
1401:|answered=
1271:(limit to
1200:Disability
1195:discussion
1163:Disability
507:column on
464:Not listed
360:under the
2777:involving
2726:WikiLinuz
2598:Mondebleu
2541:Dexedream
2526:Dexedream
2486:Dexedream
2457:Dexedream
2344:Dexedream
2279:MOS:PHARM
2122:Rifamycin
1997:Butirosin
1891:lysergide
1850:MOS:PHARM
1845:MOS:PHARM
1699:Dexedream
1631:Change B:
1619:Change A:
1418:Change A:
1284:provides
1265:provides
658:Chemicals
648:chemicals
611:Chemicals
580:is rated
497:Main Page
101:if needed
84:Be polite
34:talk page
3114:See the
3024:Seppi333
2879:Not done
2677:WP:MEDRS
2555:WP:MEDRS
2275:WT:PHARM
2107:Pecazine
2007:Ciprofol
858:Medicine
799:Medicine
582:GA-class
530:dopamine
445:Reviewed
374:reassess
319:traveled
222:Archives
191:Springer
156:Cochrane
69:get help
42:This is
40:article.
2962:abusers
2745:classes
2513:Insert
2443:Insert
2413:Insert
2395:cocaine
2304:Insert
2234:JoeBo82
2221:Insert
2193:JoeBo82
2180:Insert
2147:Trazium
1839:JoeBo82
1824:JoeBo82
1810:Insert
1783:JoeBo82
1734:Insert
1475:Medical
1362:history
1352:Copied
1339:history
1329:Copied
1138:on the
1030:defunct
1004:defunct
974:on the
885:on the
774:on the
685:on the
532:in the
499:in the
404:Process
315:defense
263:30Â days
2478:actual
2283:really
2271:WT:MED
2261:, and
2127:Savlon
2102:Niacin
1905:, and
1471:"Uses"
1263:PubMed
1111:Autism
1098:autism
1070:Autism
588:scale.
483:Listed
407:Result
179:OpenMD
149:PubMed
2895:Linuz
2825:|ans=
2815:This
2756:Linuz
2688:Linuz
2669:WP:OR
2624:Linuz
2566:Linuz
2502:Seppi
2432:Seppi
2402:Seppi
2293:Seppi
2277:, or
2210:Seppi
2169:Seppi
1799:Seppi
1762:Linuz
1723:Seppi
1599:|ans=
1589:This
1532:Linuz
1473:and "
1405:|ans=
1395:This
1358:oldid
1335:oldid
569:This
534:brain
311:color
227:Index
205:Wiley
97:Seek
3193:talk
3172:talk
3148:talk
3140:Done
3124:talk
3094:talk
3081:GPCR
3054:Re:
3034:talk
2904:talk
2890:Wiki
2863:talk
2791:talk
2765:talk
2751:Wiki
2735:talk
2712:talk
2697:talk
2683:Wiki
2654:talk
2633:talk
2619:Wiki
2615:. --
2611:See
2602:talk
2575:talk
2561:Wiki
2545:talk
2530:talk
2490:talk
2461:talk
2385:and
2373:and
2348:talk
2238:talk
2197:talk
2077:MDMA
1934:MDMA
1828:talk
1771:talk
1757:Wiki
1703:talk
1661:Done
1645:talk
1563:talk
1541:talk
1527:Wiki
1520:Done
1504:talk
1370:diff
1364:) â
1347:diff
1341:) â
1299:and
1280:The
1130:High
1100:and
877:High
766:High
677:High
401:Date
198:Trip
172:Gale
164:DOAJ
86:and
2823:or
2506:333
2436:333
2406:333
2297:333
2214:333
2173:333
2062:LSD
1803:333
1749:to
1727:333
1597:or
1403:or
1302:CDC
966:Mid
521:Ice
212:TWL
3214::
3195:)
3174:)
3150:)
3126:)
3111:]
3096:)
3036:)
2907:)
2865:)
2829:no
2793:)
2768:)
2737:)
2714:)
2700:)
2656:)
2636:)
2604:)
2578:}
2547:)
2532:)
2518:)
2515:2¢
2492:)
2463:)
2448:)
2445:2¢
2418:)
2415:2¢
2350:)
2309:)
2306:2¢
2273:,
2269:,
2257:,
2253:,
2240:)
2226:)
2223:2¢
2199:)
2185:)
2182:2¢
1901:,
1897:,
1893:,
1830:)
1815:)
1812:2¢
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