204:. DNA transposons are also known as jumping genes because they move around the chromosome and can insert themselves into different DNA sequences. The ability of these genes to move around is extremely important in DNA's flexibility and ensuring that there are different combinations of DNA in genes. These transposons can also be the source of mutations. They can also help to increase the stability of certain DNA sequences. One aspect of some transposons that is important for research is that they can help bacteria exchange antibiotic resistance genes. Baker focused on one such transposon called the
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unfoldase. In addition to unfoldases, she looks at adaptors, which are proteins that aid the unfoldases. The AAA+ family of unfoldases is in all organisms and plays an important role in maintaining which proteins are active within a cell. Unfoldases help to destroy proteins that have become damaged
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involved with bacterial resistance. Retrotransposons are transposons that first transcribe the moving gene sequence into RNA. This RNA then gets retro-transcribed back into DNA, and it is this DNA that ends up being reincorporated somewhere else in the chromosome. Through her work with these
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or proteins that have built up too much. They are important in ensuring that proteins are properly recycled so that cells do not constantly need new amino acids. Baker wants to figure how unfoldases work and how they are controlled by cells.
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Sauer, R. T.; Bolon, D. N.; Burton, B. M.; Burton, R. E.; Flynn, J. M.; Grant, R. A.; Hersch, G. L.; Joshi, S. A.; Kenniston, J. A.; Levchenko, I.; Neher, S. B.; Oakes, E. S.; Siddiqui, S. M.; Wah, D. A.; Baker, T. A. (2004).
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188:. Baker eventually helped discover the sequential steps that each enzyme and protein performed in order to start DNA replication in vivo. Baker performed this research during the time it took to get her master's and Ph.D.
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at specific sequences found on the chromosome, but the individual role of each enzyme and protein had not yet been established. There had been tests to figure this out
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Eventually, Baker left the
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Currently, most of Baker's work focuses on these unfoldases. She works specifically with the
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different transposons, Baker started to look at unfoldases, which are a type of protein
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van der Ende, Arie; Baker, Tania A.; Ogawa, Tohru; Kornberg, Arthur (June 1985).
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Tania Baker started her major research when she became a graduate student at
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For her postdoctoral research, she worked with
Kiyoshi Mizuuchi at the
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Abdelhakim, A. H.; Oakes, E. C.; Sauer, R. T.; Baker, T. A. (2008).
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Massachusetts
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transposons and similarity to bacteria resistance transposons"
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Members of the United States
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unfoldase family and has done a lot of research on the
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481:"AAA+ unfoldases roles in cells"
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327:"Enzymes and DNA replication"
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152:. She is a member of the
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381:Genes and Development
118:Department of Biology
208:transposon found in
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52:Clp/HSP1000 ATPases
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