190:
response, to be used as a potential basis for regulatory approval. She played a key role in developing FDA’s policy on accelerated approval using pathological complete response as a novel regulatory endpoint in the neoadjuvant high-risk breast cancer setting. Similar policies were subsequently adopted by other global regulatory agencies. Relevant articles include "Residual
Disease after Neoadjuvant Therapy — Developing Drugs for High-Risk Early Breast Cancer" and "Pathological Complete Response and Accelerated Drug Approval in Early Breast Cancer".
205:
setting. Prowell has been a particular advocate for inclusion of patients with brain metastases in clinical trials given the prevalence of the condition and their high degree of unmet medical need. NCI Cancer
Therapy Evaluation Program (CTEP) subsequently announced that the updated eligibility criteria were mandatory for use in all CTEP-sponsored clinical trials. Following widespread adoption of these criteria, multiple drugs have demonstrated effectiveness against brain metastases.
31:
225:
messages from thousands of prospective convalescent plasma donors, as well as others also seeking plasma for their own family members. Prowell worked to connect potential donors and recipients to donation centers throughout the U.S. before the U.S. Food and Drug
Administration and the American Red Cross set up a convalescent plasma donation program. By April 10, 2020,
364:
Prowell was the recipient of an
American Society of Clinical Oncology Young Investigator Award and two Pearl M. Stetler awards for women in medicine. In 2019, she received the John and Samuel Bard Award in Science or Medicine for her contributions to the field of oncology. Prowell was also recognized
258:
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R,
193:
In 2014, Prowell began advocating for routine inclusion of male patients with breast cancer in clinical trials. By 2021, the FDA reported that the majority of breast cancer clinical trials now permit male patients to enroll and that recent drug approvals in breast cancer have been granted regardless
224:
Prowell rose to prominence on
Twitter during the COVID-19 pandemic as a reliable source of medical news and public health commentary. In March 2020, she tweeted seeking a convalescent plasma donor for a physician family member who was critically ill with COVID-19. The tweet led to an outpouring of
189:
In 2012, Prowell and Pazdur co-published new FDA guidelines which would allow non-approved drugs to be tested on highly aggressive types of breast cancer before women underwent surgery, with the disappearance of all cancer after treatment in the pathological specimen, known as pathological compete
898:
Lin, Nancy U.; Murthy, Rashmi K.; Abramson, Vandana; Anders, Carey; Bachelot, Thomas; Bedard, Philippe L.; Borges, Virginia; Cameron, David; Carey, Lisa A.; Chien, A. Jo; Curigliano, Giuseppe; Digiovanna, Michael P.; Gelmon, Karen; Hortobagyi, Gabriel; Hurvitz, Sara A.; Krop, Ian; Loi, Sherene;
769:
Kim, Edward S.; Bruinooge, Suanna S.; Roberts, Samantha; Ison, Gwynn; Lin, Nancy U.; Gore, Lia; Uldrick, Thomas S.; Lichtman, Stuart M.; Roach, Nancy; Beaver, Julia A.; Sridhara, Rajeshwari; Hesketh, Paul J.; Denicoff, Andrea M.; Garrett-Mayer, Elizabeth; Rubin, Eric; Multani, Pratik; Prowell,
204:
In 2017, Prowell and colleagues called for further modernization of eligibility criteria to improve patient access to clinical trials of investigational cancer treatments and to ensure that enrolled populations are representative of patients likely to receive these treatments in the postmarket
837:
Lin, Nancy U.; Prowell, Tatiana; Tan, Antoinette R.; Kozak, Marina; Rosen, Oliver; Amiri-Kordestani, Laleh; White, Julia; Sul, Joohee; Perkins, Louise; Beal, Katherine; Gaynor, Richard; Kim, Edward S. (20 November 2017). "Modernizing
Clinical Trial Eligibility Criteria: Recommendations of the
242:
and
Prowell co-founded Healthcare Workers Vs. Hunger, a volunteer-led, weeklong annual contest between teams of health care workers on Twitter (#HCWvsHunger) to address food insecurity during the COVID-19 pandemic and improve the morale of healthcare workers. As of December 2023,
156:
in his NIH Laboratory of
Central Nervous System Studies, where she conducted basic science research in spongiform encephalopathies and served as the editor of several years of Gajdusek's personal diaries housed in the National Library of Medicine, she was accepted into the
220:
document intended to address these issues as well as mitigate unconscious gender and racial bias in speaker introductions at conferences. By 2022, the
Language of Respect guidelines had been translated into five languages and adapted for use by 17 professional societies.
177:
Prowell completed an internal medicine residency in the Osler
Housestaff Training Program and medical oncology fellowship at the Sidney Kimmel Comprehensive Cancer Center, both at Johns Hopkins. In 2006, Prowell was recruited by
186:(FDA). She has held joint appointments since that time at Johns Hopkins University School of Medicine where she is an Associate Professor of Oncology and at the FDA where she serves as Breast Cancer Scientific Liaison.
1210:
616:
901:"Tucatinib vs Placebo, Both in Combination with Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients with Brain Metastases"
628:
Prowell, Tatiana M.; Beaver, Julia A.; Pazdur, Richard (February 14, 2019). "Residual Disease after Neoadjuvant Therapy — Developing Drugs for High-Risk Early Breast Cancer".
772:"Broadening Eligibility Criteria to Make Clinical Trials More Representative: American Society of Clinical Oncology and Friends of Cancer Research Joint Research Statement"
899:
Loibl, Sibylle; Mueller, Volkmar; Oliveira, Mafalda; Paplomata, Elisavet; Pegram, Mark; Slamon, Dennis; Zelnak, Amelia; Ramos, Jorge; Feng, Wentao; Winer, Eric (2023).
417:
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in May 2020 for "her use of the Internet to organize a blood drive and to inspire COVID-19 survivors to donate their plasma to those still in the fight to recover."
1422:
819:
740:
617:
https://www.ema.europa.eu/en/documents/scientific-guideline/draft-guideline-role-pathological-complete-response-endpoint-neoadjuvant-breast-cancer-studies_en.pdf
1432:
1189:"Wow, Mt. Sinai says 20,000 people have reached out to donate plasma. 125 people have donated/are scheduled to donate. 37 patients have received plasma so far"
722:
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Prowell grew up in Atlanta, Georgia, Her father was a federal employee working for the U.S. Geological Survey and her mother a homemaker. She attended
1427:
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journalist Sarah Zhang reported that 20,000 potential donors reached out to Mount Sinai Hospital. Prowell's tweet and subsequent efforts earned her a
1407:
445:
872:
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671:
Prowell, Tatiana M.; Pazdur, Richard (June 28, 2012). "Pathological Complete Response and Accelerated Drug Approval in Early Breast Cancer".
213:
152:, where she was encouraged by her academic advisor, Clark Rodewald, to pursue a medical career. After a year working with Nobel Laureate
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1211:"The 24th Annual Webby Awards Celebrates & Honors the Individuals and Organizations Using the Internet in Response to COVID-19"
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Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G (July 2014).
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Prowell TM, Pazdur R (2012-06-28). "Pathological Complete Response and Accelerated Drug Approval in Early Breast Cancer".
1417:
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820:"Pink Sheet - Cancer Trials: Broader Eligibility Criteria Could Mean Novel Labeling Claims - Friends of Cancer Research"
1133:
212:
have called upon the field of medicine to abandon language that dehumanizes patients. While serving as Chair of the
770:
Tatiana M.; Schenkel, Caroline; Kozak, Marina; Allen, Jeff; Sigal, Ellen; Schilsky, Richard L. (20 November 2017).
527:
125:
is an American medical oncologist specializing in breast cancer. She is an Associate Professor of Oncology at
261:"Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis"
873:
https://ctep.cancer.gov/protocoldevelopment/docs/CTEP_Memorandum_Broaden_Eligibility_Criteria_Initiative.pdf
1387:
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153:
900:
885:"Trastuzumab Deruxtecan Induces Responses in Patients with HER2+ Breast Cancer and Brain Metastases"
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American Society of Clinical Oncology–Friends of Cancer Research Brain Metastases Working Group".
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1326:"100 Influential Women in Oncology: Key Opinion Leaders to follow on Social Media in 2023"
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1095:"Journal of Clinical Oncology (JCO) Podcast: What's in a Name? An Introductory Guide"
723:"Men with Breast Cancer Need More Treatment Options and Access to Genetic Counseling"
329:
Prowell TM, Theoret MR, Pazdur R (2016-04-13). "Seamless Oncology-Drug Development".
292:
657:
446:"How I Became an Academic Oncologist and FDA Medical Officer and Scientific Liaison"
418:"Insightful Advice From a College Advisor Leads to an Unexpected Career in Oncology"
1300:"Bard College Holds One Hundred Fifty-Ninth Commencement on Saturday, May 25, 2019"
1166:
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391:"Clinical Trials for People with Metastatic Breast Cancer with Dr. Tatiana Prowell"
227:
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had raised more than 2.3 million dollars for food banks and hunger organizations.
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and Breast Cancer Scientific Liaison at the U.S. Food & Drug Administration.
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to the Biden Cancer Moonshot Blue Ribbon Panel Cancer Immunology Working Group.
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1109:""Call me Doctor" How women in oncology are fighting for cultural change"
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473:"From 'Yuppie' Parkview High School, Students Demand Amnesty For Others"
1196:
523:
Radical: The Science, Culture, and History of Breast Cancer in America
560:"U.S. regulators to allow women to test breast cancer drugs earlier"
161:. She graduated in 1999 with a medical degree and election to the
216:'s 2020 Annual Meeting Education Committee, Prowell co-authored
365:
as one of the 100 Influential Women in Oncology by OncoDaily.
1122:
https://twitter.com/tmprowell/status/1533035835364450307?s=20
244:
1250:
949:"Melanoma Brain Metastases: 'Absolutely Treatable in 2021'"
1148:"10 Women in Medicine You Need to Follow on Social Media"
1040:"'An Emotional Slap in the Face': The Language of Cancer"
16:
American medical oncologist specializing in breast cancer
991:"Words Matter: Use of Respectful Language in Oncology"
373:
In 2004 she married Todd Gleeson, an HIV specialist.
1038:
Dizon, Don S.; Prowell, Tatiana M. (June 17, 2019).
108:
103:
87:
82:
70:
47:
37:
21:
1163:"America Needs Plasma From COVID-19 Survivors Now"
995:Journal of the Advanced Practitioner in Oncology
964:"These Are the Words Doctors Should Stop Saying"
495:"Students Elected to Phi Beta Kappa April 1999"
8:
1134:"Program Guide – ASCO Meeting Program Guide"
112:Johns Hopkins University School of Medicine
98:Johns Hopkins University School of Medicine
29:
18:
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606:https://www.fda.gov/media/83507/download
989:Zitella, L. J.; Prowell, T. M. (2021).
382:
1423:21st-century American women physicians
440:
438:
471:Pendered, Daniel (November 1, 1988).
214:American Society of Clinical Oncology
91:B.A., literature and language, 1994,
7:
1433:Physicians from Georgia (U.S. state)
416:Piana, Ronald (September 10, 2019).
141:for her secondary school education.
558:Steenhuysen, Julie (June 4, 2012).
184:U.S. Food & Drug Administration
14:
962:Abramowitz, Ben (July 19, 2019).
741:"Cancer Immunology Working Group"
520:Pickert, Kate (October 1, 2019).
197:Prowell was appointed in 2016 by
1428:21st-century American physicians
1413:Johns Hopkins University faculty
1275:"Bard College Awards Recipients"
709:"Men Develop Breast Cancer, Too"
159:Johns Hopkins School of Medicine
127:Johns Hopkins School of Medicine
1408:Johns Hopkins University alumni
1161:Zhang, Sarah (March 28, 2020).
674:New England Journal of Medicine
630:New England Journal of Medicine
331:New England Journal of Medicine
302:New England Journal of Medicine
60:
1251:"Healthcare Workers vs Hunger"
1187:@sarahzhang (April 10, 2020).
1068:Cavallo, Jo (April 10, 2020).
970:. Syneos Health Communications
968:syneoshealthcommunications.com
750:. October 17, 2016. p. 67
1:
277:10.1016/S0140-6736(13)62422-8
1255:Healthcare Workers vs Hunger
840:Journal of Clinical Oncology
776:Journal of Clinical Oncology
917:10.1001/jamaoncol.2022.5610
570:– via Newspapers.com.
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1398:American women oncologists
1346:. May 31, 2004. p. 62
1007:10.6004/jadpro.2021.12.3.3
824:Friends of Cancer Research
475:. The Atlanta Constitution
528:Little, Brown and Company
233:Webby Special Achievement
116:
78:
28:
1371:publications indexed by
852:10.1200/JCO.2017.74.0761
788:10.1200/JCO.2017.73.7916
148:degree in literature at
133:Early life and education
123:Tatiana Michelle Prowell
218:The Language of Respect
1344:"Bardian 2004 Summer"
582:"Tatiana Prowell, MD"
251:Selected publications
42:Atlanta, Georgia, USA
1393:American oncologists
1332:. 16 September 2023.
687:10.1056/NEJMp1205737
642:10.1056/NEJMp1900079
562:. The Ottawa Citizen
343:10.1056/nejmp1603747
314:10.1056/NEJMp1205737
154:D. Carleton Gajdusek
144:Prowell completed a
139:Parkview High School
1418:People from Atlanta
1403:Bard College alumni
1279:annandaleonline.org
1237:"Explore the Space"
1111:. 13 December 2019.
1070:"What's in a Name?"
452:. February 26, 2018
450:connection.asco.org
83:Academic background
395:realpink.komen.org
360:Awards and honours
238:In December 2020,
846:(33): 3760–3773.
782:(33): 3737–3744.
681:(26): 2438–2441.
397:. January 6, 2020
337:(21): 2001–2003.
308:(26): 2438–2441.
271:(9938): 164–172.
169:honor societies.
167:Alpha Omega Alpha
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146:Bachelor of Arts
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1306:. May 25, 2019
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