378:
355:
252:
277:
2543:, are also infectious with the capability to cross species. Since tau has yet to be proven to be infectious it is not considered to be a true prion but instead a "prion-like" protein. Much like true prions, pathological tau aggregates have been shown to have the capacity to induce misfolding of native tau protein. Both misfolding competent and non-misfolding competent species of tau aggregates have been reported, indicating a highly specific mechanism.
2209:, H1 and H2, in which the gene appears in inverted orientations. Haplogroup H2 is common only in Europe and in people with European ancestry. Haplogroup H1 appears to be associated with increased probability of certain dementias, such as Alzheimer's disease. The presence of both haplogroups in Europe means that recombination between inverted haplotypes can result in the lack of one of the functioning copies of the gene, resulting in congenital defects.
643:
636:
629:
2429:(NFTs). The stage of the disease determines NFTs' phosphorylation. In AD, at least 19 amino acids are phosphorylated; pre-NFT phosphorylation occurs at serine 199, 202 and 409, while intra-NFT phosphorylation happens at serine 396 and threonine 231. Through its isoforms and phosphorylation, tau protein interacts with tubulin to stabilize microtubule assembly. All of the six tau isoforms are present in an often hyperphosphorylated state in
384:
283:
1944:
2288:
tubulin, which in turn enhances fibrilization of tau. Several propagation methods have been proposed that occur by synaptic contact such as synaptic cell adhesion proteins, neuronal activity and other synaptic and non-synaptic mechanisms. The mechanism of tau aggregation is still not completely elucidated, but several factors favor this process, including tau phosphorylation and zinc ions.
2253:. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization. Phosphorylation of tau is also developmentally regulated. For example, fetal tau is more highly phosphorylated in the embryonic CNS than adult tau. The degree of phosphorylation in all six isoforms decreases with age due to the activation of
2436:
Tau mutations have many consequences, including microtubule dysfunction and alteration of the expression level of tau isoforms. Mutations that alter function and isoform expression of tau lead to hyperphosphorylation. The process of tau aggregation in the absence of mutations is not known but might
2287:
The accumulation of hyperphosphorylated tau in neurons is associated with neurofibrillary degeneration. The actual mechanism of how tau propagates from one cell to another is not well identified. Also, other mechanisms, including tau release and toxicity, are unclear. As tau aggregates, it replaces
1955:
technique. MAP2 is found only in dendrites and perikarya, while tau is found not only in the dendrites and perikarya but also in axons. As a result, axons appear red while the dendrites and perikarya appear yellow, due to superimposition of the red and green signals. DNA is shown in blue using the
2464:
Hyperphosphorylated forms of tau protein are the main component of PHFs of NFTs in the brain of AD patients. It has been well demonstrated that regions of tau six-residue segments, namely PHF6 (VQIVYK) and PHF6* (VQIINK), can form tau PHF aggregation in AD. Apart from the PHF6, some other residue
63:
2408:
Gender-specific tau gene expression across different regions of the human brain has recently been implicated in gender differences in the manifestations and risk for tauopathies. Some aspects of how the disease functions also suggest that it has some similarities to
2477:, a component of the pathologic lesion seen in Alzheimer disease. A recent hypothesis identifies the decrease of reelin signaling as the primary change in Alzheimer's disease that leads to the hyperphosphorylation of tau via a decrease in GSK3β inhibition.
2401:, this otherwise very soluble protein can form extremely insoluble aggregates that contribute to a number of neurodegenerative diseases. Tau protein has a direct effect on the breakdown of a living cell caused by tangles that form and block nerve
6842:
Deutsch SI, Rosse RB, Lakshman RM (December 2006). "Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications".
4366:
Matsuo ES, Shin RW, Billingsley ML, Van deVoorde A, O'Connor M, Trojanowski JQ, et al. (October 1994). "Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as
Alzheimer's disease paired helical filament tau".
3946:
Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (December 1986). "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2".
2225:
of the protein and are positively charged (allowing it to bind to the negatively charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. Tau is a
2864:
Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (October 1989). "Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of
Alzheimer's disease".
4023:
Shaw-Smith C, Pittman AM, Willatt L, Martin H, Rickman L, Gribble S, et al. (September 2006). "Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability".
2084:(a form of non-associative learning), two higher and more integrated physiological functions. Since regulation of tau is critical for memory, this could explain the linkage between tauopathies and cognitive impairment.
2515:(CTE), a condition characterized by fibrillar tangles of hyperphosphorylated tau. After severe traumatic brain injury, high levels of tau protein in extracellular fluid in the brain are linked to poor outcomes.
2465:
sites like Ser285, Ser289, Ser293, Ser305 and Tyr310, located near the C-terminal of the PHF6 sequences, play key roles in the phosphorylation of tau. Hyperphosphorylated tau differs in its sensitivity and its
4471:"Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau"
2640:
3756:
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, et al. (May 2007). "Reducing endogenous tau ameliorates amyloid beta-induced deficits in an
Alzheimer's disease mouse model".
6813:
Hardy J, Pittman A, Myers A, Gwinn-Hardy K, Fung HC, de Silva R, et al. (August 2005). "Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens".
4157:
Hardy J, Pittman A, Myers A, Gwinn-Hardy K, Fung HC, de Silva R, et al. (August 2005). "Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens".
2959:
Shin RW, Iwaki T, Kitamoto T, Tateishi J (May 1991). "Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and
Alzheimer's disease brain tissues".
5219:
Augustinack JC, Schneider A, Mandelkow EM, Hyman BT (January 2002). "Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in
Alzheimer's disease".
2198:
has four repeats (R1, R2, R3 and R4) and two inserts (441 amino acids total), while the shortest isoform has three repeats (R1, R3 and R4) and no insert (352 amino acids total).
6679:
van
Swieten JC, Rosso SM, van Herpen E, Kamphorst W, Ravid R, Heutink P (2004). "Phenotypic variation in frontotemporal dementia and parkinsonism linked to chromosome 17".
4580:
3159:
Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T, et al. (June 1994). "Altered microtubule organization in small-calibre axons of mice lacking tau protein".
2807:"Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau"
3026:
Cleveland DW, Hwo SY, Kirschner MW (October 1977). "Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin".
391:
290:
7214:
2087:
In mice, while the reported tau knockout strains present without overt phenotype when young, when aged, they show some muscle weakness, hyperactivity, and impaired
5920:"Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury"
6880:
Williams DR (October 2006). "Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau".
3061:
Cleveland DW, Hwo SY, Kirschner MW (October 1977). "Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly".
5777:
Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH (July 2005). "Chronic traumatic encephalopathy in a
National Football League player".
2571:
6317:"Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II"
1351:
213:
6774:
Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, et al. (April 2005). "Tau phosphorylation in
Alzheimer's disease: pathogen or protector?".
4954:
Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, et al. (April 2005). "Tau phosphorylation in
Alzheimer's disease: pathogen or protector?".
2393:. All of the six tau isoforms are present in an often hyperphosphorylated state in paired helical filaments in the Alzheimer's disease brain. In other
1332:
7165:
2425:
states that excessive or abnormal phosphorylation of tau results in the transformation of normal adult tau into paired-helical-filament (PHF) tau and
1978:
Tau proteins are found more often in neurons than in non-neuronal cells in humans. One of tau's main functions is to modulate the stability of axonal
1936:. The tau proteins were identified in 1975 as heat-stable proteins essential for microtubule assembly, and since then they have been characterized as
4194:"Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration"
2238:(Thr) phosphorylation sites on the longest tau isoform. Phosphorylation has been reported on approximately 30 of these sites in normal tau proteins.
3109:"Drosophila Tau Negatively Regulates Translation and Olfactory Long-Term Memory, But Facilitates Footshock Habituation and Cytoskeletal Homeostasis"
5072:"Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies"
5982:
Dujardin S, Hyman BT (2019). "Tau Prion-Like
Propagation: State of the Art and Current Challenges". In Takashima A, Wolozin B, Buee L (eds.).
3713:
Ikegami S, Harada A, Hirokawa N (February 2000). "Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice".
9529:
5999:
2725:
7842:
2707:
6576:
Blennow K, Vanmechelen E, Hampel H (2002). "CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease".
2449:. Hyperphosphorylated tau disassembles microtubules and sequesters normal tau, MAPT 1 (microtubule associated protein tau 1), MAPT 2 and
2308:
mutations that change the extracellular level of tau. According to Asai and his colleagues, the spreading of tau protein occurs from the
377:
7207:
6438:
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, et al. (1995). "Hyperphosphorylation of tau in PHF".
1794:
6737:
Rademakers R, Cruts M, van Broeckhoven C (October 2004). "The role of tau (MAPT) in frontotemporal dementia and related tauopathies".
1787:
354:
2344:. The degree of toxicity is affected by different factors, such as the degree of microtubule binding. Toxicity could also happen by
2304:. On the other hand, tau release depends on neuronal activity. Many factors influence tau release, for example, type of isoforms or
2186:
with a range of 352–441 amino acids. Tau isoforms are different in having either zero, one, or two inserts of 29 amino acids at the
1937:
5452:"Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin"
2221:. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the
4282:
Kanemaru K, Takio K, Miura R, Titani K, Ihara Y (May 1992). "Fetal-type phosphorylation of the tau in paired helical filaments".
2986:
Lei P, Ayton S, Finkelstein DI, Adlard PA, Masters CL, Bush AI (November 2010). "Tau protein: relevance to Parkinson's disease".
2512:
2491:
blood test for the p-tau-217 form of the protein could diagnose Alzheimer's up to decades before dementia symptoms were evident.
2012:
to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability:
2296:
Tau involves in uptake and release process, which is known as seeding. Uptake of tau protein mechanism requires the presence of
8361:
6135:"alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356"
2694:
2673:
1986:
4858:"PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila"
8630:
8473:
7200:
6948:
Roder HM, Hutton ML (April 2007). "Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease".
2625:
1878:
276:
251:
6401:
Goedert M, Crowther RA, Garner CC (May 1991). "Molecular characterization of microtubule-associated proteins tau and MAP2".
2690:
60:
9509:
9063:
2669:
2612:
2329:
2297:
184:, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule associated protein tau, Tau proteins, tau-40
6716:
Kowalska A, Jamrozik Z, Kwieciński H (2004). "Progressive supranuclear palsy--parkinsonian disorder with tau pathology".
3213:
Wang JZ, Liu F (June 2008). "Microtubule-associated protein tau in development, degeneration and protection of neurons".
1993:
that did not show abnormalities in brain development – possibly because of compensation in tau deficiency by other MAPs.
2328:
Tau causes toxic effects through its accumulation inside cells. Many enzymes are involved in toxicity mechanism such as
2103:
2001:
193:
7770:
2552:
2332:
kinase. This enzyme stimulates phosphorylation of serine 262 and 356, which in turn leads to activate other kinases (
4666:"The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?"
2539:
are defined by their ability to induce misfolding of native proteins to perpetuate the pathology. True prions, like
390:
289:
9241:
2394:
6219:"Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau"
5509:
Vincent IJ, Davies P (October 1990). "Phosphorylation characteristics of the A68 protein in Alzheimer's disease".
2620:
383:
282:
6268:"S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease"
3857:
2182:, which leads to the formation of six tau isoforms. In the human brain, tau proteins constitute a family of six
9474:
7154:
5350:"Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer's Disease"
5001:"Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments"
2175:
1404:
201:
2670:
ENSG00000276155, ENSG00000277956 GRCh38: Ensembl release 89: ENSG00000186868, ENSG00000276155, ENSG00000277956
5712:"Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders"
5070:
Köglsberger S, Cordero-Maldonado ML, Antony P, Forster JI, Garcia P, Buttini M, et al. (December 2017).
4118:"H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population"
7160:
3469:"Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis"
2532:
2386:
1933:
1385:
1381:
1377:
1901:
has the highest abundance. They are less common elsewhere but are also expressed at very low levels in CNS
5305:
Mudher A, Lovestone S (January 2002). "Alzheimer's disease-do tauists and baptists finally shake hands?".
4907:"Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model"
4327:"The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases"
2607:
2528:
2500:
2426:
2382:
2374:
2345:
2195:
1925:
1921:
1894:
6613:
Ingram EM, Spillantini MG (December 2002). "Tau gene mutations: dissecting the pathogenesis of FTDP-17".
5822:"Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model"
3107:
Papanikolopoulou K, Roussou IG, Gouzi JY, Samiotaki M, Panayotou G, Turin L, et al. (October 2019).
2008:, where it provides microtubule stabilization but also flexibility as needed. Tau proteins interact with
7893:
7247:
2167:
2040:
265:
5627:
3409:"Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling"
2130:. Atypical, non-standard roles of tau are also under current investigation, such as its involvement in
8162:
5463:
5012:
4482:
4423:
3765:
3168:
2818:
2759:
2602:
2481:
2470:
2362:
2179:
2065:
2054:
1867:
2257:. Like kinases, phosphatases too play a role in regulating the phosphorylation of tau. For example,
2217:
Six tau isoforms exist in human brain tissue, and they are distinguished by their number of binding
180:
9469:
8102:
5710:
Palmqvist S, Janelidze S, Quiroz YT, Zetterberg H, Lopera F, Stomrud E, et al. (August 2020).
3895:
Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, et al. (November 2017).
3256:
Ke YD, Suchowerska AK, van der Hoven J, De Silva DM, Wu CW, van Eersel J, et al. (June 2012).
2024:
1961:
1929:
1770:
1766:
1762:
1758:
1754:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1722:
1718:
1714:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1674:
1670:
1666:
1652:
1648:
1644:
1640:
1625:
1621:
1617:
1613:
1587:
1583:
1579:
1575:
1555:
1551:
1547:
1539:
1518:
1514:
1510:
1506:
1480:
1476:
1472:
1468:
4664:
Fichou Y, Al-Hilaly YK, Devred F, Smet-Nocca C, Tsvetkov PO, Verelst J, et al. (March 2019).
3467:
Meier S, Bell M, Lyons DN, Rodriguez-Rivera J, Ingram A, Fontaine SN, et al. (January 2016).
7922:
7552:
7024:
6973:
6905:
6868:
6762:
6704:
6667:
6601:
6463:
6426:
6199:
6025:
6013:
5869:
McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, et al. (January 2013).
5802:
5534:
5330:
5287:
5244:
4887:
4392:
4307:
4049:
3789:
3738:
3692:
3664:
3338:
3238:
3192:
2890:
2446:
1952:
225:
5918:
Magnoni S, Esparza TJ, Conte V, Carbonara M, Carrabba G, Holtzman DM, et al. (April 2012).
5262:
van Slegtenhorst M, Lewis J, Hutton M (July 2000). "The molecular genetics of the tauopathies".
4579:
Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, et al. (May 2015).
1656:
1609:
1605:
1601:
1591:
1543:
1502:
1498:
1494:
1484:
4412:"O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease"
2000:
at low levels, where it is involved in postsynaptic scaffolding, it is active primarily in the
9534:
9320:
9023:
7684:
7172:
7131:
7088:
7067:
7016:
6965:
6936:
6897:
6860:
6830:
6801:
6754:
6725:
6696:
6659:
6630:
6593:
6564:
6543:
6522:"Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease"
6508:
6455:
6418:
6379:
6338:
6297:
6248:
6191:
6156:
6115:
6074:
6005:
5995:
5949:
5900:
5851:
5794:
5741:
5692:
5635:
5585:
5526:
5491:
5432:
5381:
5322:
5279:
5236:
5201:
5150:
5101:
5040:
4981:
4936:
4879:
4838:
4789:
4738:
4697:
4646:
4605:
4561:
4510:
4451:
4384:
4348:
4299:
4264:
4223:
4174:
4139:
4098:
4067:
Zody MC, Jiang Z, Fung HC, Antonacci F, Hillier LW, Cardone MF, et al. (September 2008).
4041:
4005:
3964:
3928:
3877:
3838:
3781:
3730:
3684:
3645:
3606:
3557:
3539:
3498:
3446:
3428:
3389:
3330:
3309:"Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models"
3289:
3230:
3184:
3138:
3078:
3043:
3003:
2968:
2941:
2908:
Sjölin K, Kultima K, Larsson A, Freyhult E, Zjukovskaja C, Alkass K, et al. (June 2022).
2882:
2846:
2787:
2635:
2508:
2309:
2269:
Ser396. The binding of these phosphatases to tau affects tau's association with microtubules.
2246:
2151:
2088:
2061:
173:
53:
9043:
5820:
Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, et al. (May 2012).
4241:
Taniguchi T, Kawamata T, Mukai H, Hasegawa H, Isagawa T, Yasuda M, et al. (March 2001).
9268:
8975:
8960:
8955:
8950:
8945:
8935:
8856:
8565:
8545:
8515:
8510:
8392:
7747:
7742:
7121:
7113:
7057:
7049:
7006:
6998:
6957:
6926:
6889:
6852:
6822:
6791:
6783:
6746:
6688:
6651:
6622:
6585:
6533:
6498:
6488:
6447:
6410:
6369:
6328:
6287:
6279:
6238:
6230:
6183:
6146:
6105:
6064:
5987:
5939:
5931:
5890:
5882:
5841:
5833:
5786:
5731:
5723:
5682:
5672:
5575:
5565:
5518:
5481:
5471:
5422:
5412:
5399:
Tepper K, Biernat J, Kumar S, Wegmann S, Timm T, Hübschmann S, et al. (December 2014).
5371:
5361:
5314:
5271:
5228:
5191:
5181:
5140:
5132:
5091:
5083:
5030:
5020:
4971:
4963:
4926:
4918:
4869:
4828:
4820:
4779:
4769:
4728:
4687:
4677:
4636:
4623:
Roman AY, Devred F, Byrne D, La Rocca R, Ninkina NN, Peyrot V, et al. (February 2019).
4595:
4551:
4541:
4500:
4490:
4441:
4431:
4376:
4338:
4291:
4254:
4213:
4205:
4166:
4129:
4088:
4080:
4033:
3995:
3956:
3918:
3908:
3869:
3828:
3820:
3807:
Dawson HN, Cantillana V, Jansen M, Wang H, Vitek MP, Wilcock DM, et al. (August 2010).
3773:
3722:
3676:
3637:
3596:
3588:
3547:
3529:
3488:
3480:
3436:
3420:
3379:
3369:
3320:
3279:
3269:
3222:
3176:
3128:
3120:
3070:
3035:
2995:
2931:
2921:
2874:
2836:
2826:
2777:
2767:
2523:
The term "prion-like" is often used to describe several aspects of tau pathology in various
2458:
2366:
2301:
2119:
2099:
2077:
2028:
1863:
642:
635:
628:
470:
401:
345:
300:
9185:
9180:
9175:
9170:
8925:
8915:
8905:
8900:
8871:
8575:
8570:
7617:
7505:
7495:
7470:
7450:
7354:
7334:
9410:
8024:
7874:
7757:
7577:
6037:
3626:"Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice"
2559:
2398:
2341:
2266:
2183:
2123:
2017:
2013:
1906:
1898:
445:
221:
4116:
Almos PZ, Horváth S, Czibula A, Raskó I, Sipos B, Bihari P, et al. (November 2008).
7150:
5467:
5060:"Alzheimer's Brain Tangles." Alzheimer's Association, www.alz.org/braintour/tangles.asp.
5016:
4807:
Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. (November 2015).
4733:
4716:
4486:
4427:
3769:
3575:
Koren SA, Hamm MJ, Meier SE, Weiss BE, Nation GK, Chishti EA, et al. (April 2019).
3307:
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, et al. (August 2010).
3172:
2822:
2763:
2397:, the deposition of aggregates enriched in certain tau isoforms has been reported. When
2023:
In addition to its microtubule-stabilizing function, Tau has also been found to recruit
9373:
9236:
7933:
7764:
7273:
7126:
7101:
7062:
7037:
7011:
6986:
6292:
6283:
6267:
6243:
6234:
6218:
5944:
5919:
5895:
5870:
5846:
5821:
5790:
5759:
5736:
5711:
5687:
5660:
5603:
5580:
5553:
5427:
5400:
5376:
5349:
5196:
5169:
5145:
5120:
5096:
5071:
4931:
4906:
4833:
4808:
4784:
4757:
4692:
4665:
4556:
4529:
4295:
4218:
4193:
4093:
4068:
3923:
3896:
3833:
3824:
3808:
3601:
3576:
3552:
3517:
3493:
3468:
3441:
3408:
3284:
3257:
3133:
3108:
2936:
2909:
2504:
2422:
2250:
2227:
2222:
2218:
2147:
2115:
1917:
6626:
6538:
6521:
6333:
6316:
5554:"Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer's Disease"
5318:
5275:
4874:
4857:
4446:
4411:
4343:
4326:
3856:
Cantero JL, Hita-Yañez E, Moreno-Lopez B, Portillo F, Rubio A, Avila J (August 2010).
3726:
3384:
3357:
2841:
2806:
2782:
2747:
1266:
1261:
1256:
1251:
1246:
1241:
1236:
1231:
1226:
1221:
1216:
1211:
1206:
1201:
1196:
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1186:
1181:
1176:
1171:
1166:
1161:
1156:
1151:
1146:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
9523:
9437:
9432:
8397:
8267:
8216:
8166:
8106:
8028:
7996:
7937:
7723:
7242:
7181:
7002:
6893:
6451:
6414:
6174:
Giasson BI, Lee VM, Trojanowski JQ (2003). "Interactions of amyloidogenic proteins".
6017:
5806:
5522:
5486:
5451:
5035:
5000:
4505:
4470:
4380:
3960:
3074:
3039:
2878:
2540:
2370:
2320:
were also involved in the transport process, and their actual role is still unknown.
2135:
1990:
671:
7028:
6977:
6909:
6766:
6708:
6671:
6605:
6467:
6430:
5538:
5334:
5291:
4891:
4624:
4396:
4311:
4053:
3793:
3742:
3696:
3342:
3242:
3226:
2894:
9281:
8336:
8091:
7635:
7227:
6872:
6203:
5248:
3484:
3196:
3124:
2474:
2378:
2138:, its interaction with other cytoskeletal or synaptic proteins, its involvement in
1943:
1882:
463:
242:
9253:
9231:
7038:"Functional MAPT haplotypes: bridging the gap between genotype and neuropathology"
5661:"Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease"
4325:
Mawal-Dewan M, Henley J, Van de Voorde A, Trojanowski JQ, Lee VM (December 1994).
2910:"Distribution of five clinically important neuroglial proteins in the human brain"
205:
6787:
6217:
Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (February 2002).
6069:
6052:
5991:
5837:
4967:
4809:"Depletion of microglia and inhibition of exosome synthesis halt tau propagation"
4600:
4000:
3983:
3809:"Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease"
3680:
2999:
2484:
form of tau protein found in the brains of individuals with Alzheimer's disease.
2091:. However, neither spatial learning in mice, nor short-term memory (learning) in
229:
9427:
9378:
9248:
8468:
7912:
7867:
7786:
7708:
7256:
6856:
6589:
6133:
Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R (September 1999).
3665:"14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice"
3625:
2730:
National Center for Biotechnology Information, U.S. National Library of Medicine
2712:
National Center for Biotechnology Information, U.S. National Library of Medicine
2630:
2524:
2488:
2454:
2313:
2254:
2139:
2081:
1979:
1032:
activation of cysteine-type endopeptidase activity involved in apoptotic process
7192:
6187:
6110:
6093:
5456:
Proceedings of the National Academy of Sciences of the United States of America
5005:
Proceedings of the National Academy of Sciences of the United States of America
4475:
Proceedings of the National Academy of Sciences of the United States of America
4416:
Proceedings of the National Academy of Sciences of the United States of America
3624:
Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI, Vitek MP (March 2001).
3592:
3534:
3325:
3308:
2926:
2811:
Proceedings of the National Academy of Sciences of the United States of America
2752:
Proceedings of the National Academy of Sciences of the United States of America
546:
9479:
9398:
9388:
9276:
8387:
8366:
8132:
8069:
8064:
8059:
8039:
8014:
8002:
7988:
7983:
7978:
7973:
7968:
7963:
7958:
7953:
7948:
7810:
7692:
7681:
7667:
7283:
7053:
6961:
5962:
5087:
4758:"Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology"
4682:
4641:
3913:
2442:
2377:
of paired helical filaments and straight filaments, which are involved in the
2206:
2191:
2187:
2131:
2045:
362:
259:
209:
6151:
6134:
6053:"Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis"
5639:
4774:
3577:"Tau drives translational selectivity by interacting with ribosomal proteins"
3543:
3432:
3424:
1147:
negative regulation of establishment of protein localization to mitochondrion
17:
9308:
9303:
9298:
9258:
9096:
9091:
9086:
8444:
8424:
8079:
8074:
8054:
8049:
8044:
8034:
7943:
7847:
7781:
6642:
Pickering-Brown S (2004). "The tau gene locus and frontotemporal dementia".
5727:
5476:
5417:
5186:
4436:
3897:"Atypical, non-standard functions of the microtubule associated Tau protein"
3873:
3777:
3374:
2831:
2596:
2450:
2430:
2390:
2357:
2317:
2235:
2127:
1997:
1902:
1296:
606:
484:
429:
416:
328:
315:
217:
7117:
7102:"Tau proteins: the molecular structure and mode of binding on microtubules"
7092:
7071:
7020:
6969:
6940:
6901:
6864:
6834:
6805:
6758:
6729:
6700:
6663:
6634:
6597:
6568:
6547:
6512:
6383:
6374:
6357:
6301:
6252:
6195:
6160:
6119:
6078:
6009:
5953:
5935:
5904:
5886:
5855:
5798:
5745:
5696:
5589:
5436:
5385:
5326:
5283:
5240:
5205:
5154:
5105:
5044:
5025:
4985:
4940:
4883:
4842:
4793:
4742:
4701:
4650:
4609:
4565:
4546:
4455:
4268:
4259:
4242:
4178:
4143:
4102:
4045:
4009:
3932:
3881:
3842:
3785:
3734:
3688:
3649:
3641:
3610:
3561:
3502:
3450:
3393:
3334:
3293:
3234:
3142:
3007:
2945:
2772:
7135:
6493:
6459:
6422:
6342:
5530:
5495:
5232:
4514:
4495:
4388:
4352:
4303:
4227:
3968:
3274:
3188:
2972:
2886:
2850:
2791:
2487:
In 2020, researchers from two groups published studies indicating that an
1834:
1829:
9422:
9383:
9315:
9288:
9155:
9143:
9018:
9013:
8454:
8449:
8371:
7805:
7800:
7662:
6931:
6918:
5677:
5570:
5366:
4922:
3082:
3047:
2438:
2402:
2273:
2050:
1913:
1818:
1449:
1430:
4530:"Propagation of tau misfolding from the outside to the inside of a cell"
4134:
4117:
3663:
Fujio K, Sato M, Uemura T, Sato T, Sato-Harada R, Harada A (July 2007).
9449:
9403:
9293:
9223:
9192:
9122:
9117:
9081:
9076:
9071:
9038:
9008:
9003:
8998:
8993:
8678:
8610:
8605:
8600:
8595:
8590:
8482:
8419:
7907:
7852:
7793:
7776:
7737:
7223:
7186:
7176:
7079:
Delacourte A (2005). "Tauopathies: recent insights into old diseases".
6826:
6750:
5963:"High levels of tau protein linked to poor recovery after brain injury"
4170:
2143:
2009:
1416:
1363:
6919:"Untangling the tau gene association with neurodegenerative disorders"
6796:
6692:
6655:
5628:"'Amazing, Isn't It?' Long-Sought Blood Test for Alzheimer's in Reach"
5136:
4976:
4209:
2961:
Laboratory Investigation; A Journal of Technical Methods and Pathology
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
9368:
9350:
9345:
9340:
9335:
9325:
9160:
9053:
9048:
9033:
9028:
8940:
8886:
8851:
8826:
8821:
8816:
8811:
8801:
8796:
8786:
8771:
8766:
8648:
8643:
8638:
8550:
8540:
8520:
8505:
8500:
8495:
8490:
8356:
8127:
8122:
7879:
7545:
7540:
7530:
7308:
6503:
3180:
2466:
2242:
2231:
1890:
1802:
1318:
4824:
4625:"Zinc Induces Temperature-Dependent Reversible Self-Assembly of Tau"
3407:
Evans HT, Benetatos J, van Roigen M, Bodea LG, Götz J (2019-07-01).
2480:
A68 is a name sometimes given (mostly in older publications) to the
2316:
region in the early stages of the disease. They also suggested that
2076:
The primary non-cellular functions of tau is to negatively regulate
4084:
4037:
2805:
Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (June 1988).
9393:
9165:
9148:
8985:
8980:
8970:
8965:
8930:
8920:
8910:
8895:
8876:
8866:
8861:
8846:
8841:
8836:
8831:
8806:
8791:
8781:
8776:
8761:
8756:
8736:
8731:
8726:
8721:
8716:
8711:
8706:
8701:
8696:
8691:
8686:
8658:
8653:
8620:
8615:
8585:
8580:
8560:
8555:
8535:
8525:
8440:
8318:
8313:
8308:
8303:
8298:
8293:
8288:
8283:
8278:
8273:
8257:
8252:
8247:
8242:
8237:
8232:
8227:
8222:
8197:
8192:
8187:
8182:
8177:
8172:
8152:
8147:
8142:
8137:
8117:
8112:
7822:
7752:
7701:
7698:
7695:
7687:
7676:
7673:
7670:
7655:
7650:
7645:
7640:
7612:
7602:
7587:
7520:
7510:
7490:
7465:
7460:
7445:
7435:
7430:
7425:
7420:
7415:
7410:
7395:
7349:
7344:
7339:
7329:
7324:
7319:
7298:
7293:
7288:
7278:
7265:
4999:
Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K (June 2001).
4581:"Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation"
2645:
2582:
2576:
2536:
2410:
2333:
2272:
Phosphorylation of tau has also been suggested to be regulated by
2005:
1947:
Neurons were grown in tissue culture and stained with antibody to
1886:
6987:"Hereditary frontotemporal dementia caused by Tau gene mutations"
3516:
Evans HT, Taylor D, Kneynsberg A, Bodea LG, Götz J (2021-06-19).
1281:
1277:
9494:
9489:
9484:
9444:
9415:
9330:
9207:
9202:
9197:
9101:
8751:
8746:
8741:
8668:
8663:
8530:
8412:
8407:
8402:
7862:
7857:
7815:
7728:
7718:
7713:
7607:
7597:
7592:
7582:
7572:
7567:
7562:
7557:
7480:
7405:
7400:
7390:
7385:
7380:
7375:
7370:
7365:
6845:
Progress in Neuro-Psychopharmacology & Biological Psychiatry
6526:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
5401:"Oligomer formation of tau protein hyperphosphorylated in cells"
3988:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
3518:"Altered ribosomal function and protein synthesis caused by tau"
2641:
Frontotemporal dementia and parkinsonism linked to chromosome 17
2337:
2262:
2258:
2171:
1957:
1948:
1881:
tau). They have roles primarily in maintaining the stability of
1871:
197:
7196:
6476:
4410:
Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX (July 2004).
2265:
are both present in human brain tissue and have the ability to
1267:
cellular response to brain-derived neurotrophic factor stimulus
651:
4905:
Chatterjee S, Sang TK, Lawless GM, Jackson GR (January 2009).
4469:
Alonso AD, Grundke-Iqbal I, Barra HS, Iqbal K (January 1997).
2599:, a class of diseases associated with accumulated tau proteins
2565:
2511:, and the concussive force of military blasts. It can lead to
5871:"The spectrum of disease in chronic traumatic encephalopathy"
4069:"Evolutionary toggling of the MAPT 17q21.31 inversion region"
2746:
Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW (May 1975).
2053:, which results in impaired ribosomal function, reduction of
7171:
Overview of all the structural information available in the
5659:
Barthélemy NR, Horie K, Sato C, Bateman RJ (November 2020).
2988:
The International Journal of Biochemistry & Cell Biology
1197:
regulation of microtubule polymerization or depolymerization
5450:
Shin RW, Bramblett GT, Lee VM, Trojanowski JQ (July 1993).
6358:"14-3-3zeta is an effector of tau protein phosphorylation"
1989:(MAPs) may perform similar functions, as suggested by tau
5986:. Vol. 1184. Singapore: Springer. pp. 305–325.
2348:(NFTs), which leads to cell death and cognitive decline.
27:
Group of six protein isoforms produced from the MAPT gene
3984:"Tau protein as a differential biomarker of tauopathies"
3358:"The MAP2/Tau family of microtubule-associated proteins"
2190:(exons 2 and 3) and three or four repeat-regions at the
453:
7161:
GeneReviews/NCBI/NIH/UW entry on MAPT-Related Disorders
2453:
into tangles of PHFs. This insoluble structure damages
1107:
plus-end-directed organelle transport along microtubule
1047:
negative regulation of mitochondrial membrane potential
6557:
Seikagaku. The Journal of Japanese Biochemical Society
1137:
positive regulation of protein localization to synapse
4717:"Propagation of Tau Aggregates and Neurodegeneration"
2748:"A protein factor essential for microtubule assembly"
1152:
positive regulation of diacylglycerol kinase activity
618:
6555:
Morishima-Kawashima M, Ihara Y (November 2001). "".
5168:
Mohandas E, Rajmohan V, Raghunath B (January 2009).
9462:
9361:
9267:
9222:
9131:
9110:
9062:
8885:
8677:
8629:
8481:
8467:
8433:
8380:
8349:
8329:
8208:
8090:
7921:
7903:
7892:
7835:
7628:
7307:
7264:
7255:
7241:
7234:
2102:, with increased wakefulness periods and decreased
1639:
1574:
1532:
1467:
1232:
regulation of microtubule cytoskeleton organization
4715:Goedert M, Eisenberg DS, Crowther RA (July 2017).
2686:
2684:
2682:
2665:
2663:
2661:
2049:, mouse, and human brains, through its binding to
1960:stain which highlights the nuclei. Image courtesy
1928:are associated with tau proteins that have become
1067:positive regulation of superoxide anion generation
3982:Sergeant N, Delacourte A, Buée L (January 2005).
3021:
3019:
3017:
2241:Phosphorylation of tau is regulated by a host of
2194:part (exon 10). Thus, the longest isoform in the
2064:, including the crucial regulator of translation
1262:cellular response to nerve growth factor stimulus
1012:positive regulation of microtubule polymerization
400:
299:
7100:Hirokawa N, Shiomura Y, Okabe S (October 1988).
6917:Pittman AM, Fung HC, de Silva R (October 2006).
6356:Hashiguchi M, Sobue K, Paudel HK (August 2000).
750:minor groove of adenine-thymine-rich DNA binding
6094:"[Prion-like Propagation Model of Tau]"
5121:"Is tau ready for admission to the prion club?"
3102:
3100:
3098:
3096:
3094:
3092:
6985:van Swieten J, Spillantini MG (January 2007).
6925:. 15. 15 Spec No 2 (Review Issue 2): R188-95.
3208:
3206:
2691:GRCm38: Ensembl release 89: ENSMUSG00000018411
2279:modification at various Ser and Thr residues.
2174:. The major tau protein in the human brain is
1951:protein in green and MAP tau in red using the
7208:
2741:
2739:
2134:stability, its interaction with the cellular
2098:In addition, tau knockout mice have abnormal
1157:regulation of response to DNA damage stimulus
8:
7185:(Microtubule-associated protein tau) at the
4243:"Phosphorylation of tau is regulated by PKN"
3262:International Journal of Alzheimer's Disease
2166:gene for encoding tau protein is located on
2095:seems to be affected by the absence of tau.
1252:negative regulation of tubulin deacetylation
1212:cellular response to reactive oxygen species
1117:negative regulation of mitochondrial fission
5558:International Journal of Molecular Sciences
1247:positive regulation of protein localization
1242:regulation of long-term synaptic depression
8478:
7918:
7900:
7261:
7252:
7238:
7215:
7201:
7193:
6681:Dementia and Geriatric Cognitive Disorders
6644:Dementia and Geriatric Cognitive Disorders
4528:Frost B, Jacks RL, Diamond MI (May 2009).
2572:Proto-oncogene tyrosine-protein kinase Src
1636:
1571:
1464:
1292:
1087:intracellular distribution of mitochondria
667:
441:
340:
237:
71:
7153:at the U.S. National Library of Medicine
7125:
7061:
7010:
6930:
6795:
6537:
6502:
6492:
6373:
6332:
6291:
6242:
6150:
6109:
6068:
5943:
5894:
5845:
5735:
5686:
5676:
5579:
5569:
5485:
5475:
5426:
5416:
5375:
5365:
5195:
5185:
5144:
5095:
5034:
5024:
4975:
4930:
4873:
4832:
4783:
4773:
4732:
4691:
4681:
4640:
4599:
4555:
4545:
4504:
4494:
4445:
4435:
4342:
4258:
4217:
4133:
4092:
3999:
3922:
3912:
3832:
3600:
3551:
3533:
3492:
3440:
3383:
3373:
3324:
3283:
3273:
3132:
2935:
2925:
2840:
2830:
2781:
2771:
1192:central nervous system neuron development
1177:regulation of signaling receptor activity
815:phosphatidylinositol bisphosphate binding
7036:Caffrey TM, Wade-Martins R (July 2007).
5348:Pradeepkiran JA, Reddy PH (March 2019).
4856:Nishimura I, Yang Y, Lu B (March 2004).
2060:Tau interacts specifically with several
1942:
1862:nit) form a group of six highly soluble
1097:regulation of calcium-mediated signaling
1007:regulation of microtubule polymerization
6520:Goedert M, Spillantini MG (July 2000).
4192:Billingsley ML, Kincaid RL (May 1997).
2657:
2437:result from increased phosphorylation,
2146:signaling, its role in the exposure to
2114:Other typical functions of tau include
1162:internal protein amino acid acetylation
1127:regulation of cellular response to heat
6033:
6023:
3858:"Tau protein role in sleep-wake cycle"
1182:negative regulation of gene expression
1072:negative regulation of kinase activity
775:protein-macromolecule adaptor activity
31:
6950:Expert Opinion on Therapeutic Targets
6092:Hosokawa M, Hasegawa M (2019-07-01).
5170:"Neurobiology of Alzheimer's disease"
5056:
5054:
3708:
3706:
3462:
3460:
3154:
3152:
2417:Tau hypothesis of Alzheimer's disease
2300:at the cell surface, which happen by
2029:microtubule-mediated axonal transport
1202:regulation of chromosome organization
1022:microtubule cytoskeleton organization
1017:positive regulation of axon extension
876:cytoplasmic ribonucleoprotein granule
405:
366:
361:
304:
263:
258:
7:
5665:The Journal of Experimental Medicine
4670:Acta Neuropathologica Communications
3901:Acta Neuropathologica Communications
3522:Acta Neuropathologica Communications
2104:non-rapid eye movements (NREM) sleep
2039:Tau is a negative regulator of mRNA
1057:cytoplasmic microtubule organization
6362:The Journal of Biological Chemistry
6321:The Journal of Biological Chemistry
6139:The Journal of Biological Chemistry
5405:The Journal of Biological Chemistry
4734:10.1146/annurev-neuro-072116-031153
4534:The Journal of Biological Chemistry
4331:The Journal of Biological Chemistry
4247:The Journal of Biological Chemistry
2178:by 11 exons. Exons 2, 3 and 10 are
1132:positive regulation of neuron death
1112:regulation of mitochondrial fission
6284:10.1523/JNEUROSCI.21-07-02240.2001
6235:10.1523/JNEUROSCI.22-03-00698.2002
5967:Washington University in St. Louis
5791:10.1227/01.NEU.0000163407.92769.ED
4296:10.1111/j.1471-4159.1992.tb10039.x
3825:10.1016/j.neuroscience.2010.04.037
1529:
1440:
1421:
1395:
1368:
1342:
1323:
941:intracellular anatomical structure
623:
565:central gray substance of midbrain
541:
479:
458:
25:
6477:"Untangling tau-related dementia"
6315:Baudier J, Cole RD (April 1988).
3258:"Lessons from tau-deficient mice"
2519:Prion-like propagation hypothesis
1938:intrinsically disordered proteins
1237:supramolecular fiber organization
1222:regulation of synaptic plasticity
1052:axonal transport of mitochondrion
790:protein homodimerization activity
7843:Wiskott–Aldrich syndrome protein
7003:10.1111/j.1750-3639.2007.00052.x
6894:10.1111/j.1445-5994.2006.01153.x
6815:Biochemical Society Transactions
6446:(3): 365–71, discussion 371–80.
5785:(1): 128–34, discussion 128–34.
5119:Hall GF, Patuto BA (July 2012).
4159:Biochemical Society Transactions
2617:Aging-related tau astrogliopathy
2513:chronic traumatic encephalopathy
2503:(TBI) is a central component of
2461:, which can lead to cell death.
2340:) that cause disease-associated
641:
634:
627:
389:
382:
376:
353:
288:
281:
275:
250:
9064:Microtubule organising proteins
6266:Yu WH, Fraser PE (April 2001).
5961:Strait JS (December 13, 2011).
3227:10.1016/j.pneurobio.2008.03.002
1987:microtubule-associated proteins
1142:neurofibrillary tangle assembly
1102:protein complex oligomerization
5826:Science Translational Medicine
3862:Journal of Alzheimer's Disease
3485:10.1523/JNEUROSCI.3029-15.2016
3125:10.1523/JNEUROSCI.0391-19.2019
2626:Progressive supranuclear palsy
2551:Tau protein has been shown to
2457:functions and interferes with
2057:and altered synaptic function.
1879:microtubule-associated protein
901:microtubule associated complex
740:protein phosphatase 2A binding
652:More reference expression data
607:More reference expression data
507:right hemisphere of cerebellum
1:
9111:Microtubule severing proteins
6627:10.1016/S1471-4914(02)02440-1
6539:10.1016/S0925-4439(00)00037-5
6334:10.1016/S0021-9258(18)60647-7
5319:10.1016/s0166-2236(00)02031-2
5276:10.1016/S0531-5565(00)00114-5
4875:10.1016/S0092-8674(04)00170-9
4721:Annual Review of Neuroscience
4344:10.1016/S0021-9258(18)47378-4
3727:10.1016/s0304-3940(99)00964-7
3356:Dehmelt L, Halpain S (2004).
2613:Primary age-related tauopathy
2298:heparan sulfate proteoglycans
1062:neuron projection development
805:histone-dependent DNA binding
795:sequence-specific DNA binding
374:
273:
9530:Genes on human chromosome 17
7771:actin depolymerizing factors
6788:10.1016/j.molmed.2005.02.008
6776:Trends in Molecular Medicine
6615:Trends in Molecular Medicine
6452:10.1016/0197-4580(95)00027-C
6415:10.1016/0166-2236(91)90105-4
6070:10.1001/jamaneurol.2013.5847
5992:10.1007/978-981-32-9358-8_23
5838:10.1126/scitranslmed.3003716
5523:10.1016/0006-8993(90)90765-4
5174:Indian Journal of Psychiatry
4968:10.1016/j.molmed.2005.02.008
4956:Trends in Molecular Medicine
4629:Journal of Molecular Biology
4601:10.1016/j.celrep.2015.04.043
4381:10.1016/0896-6273(94)90264-X
4001:10.1016/j.bbadis.2004.06.020
3961:10.1016/0169-328x(86)90033-1
3681:10.1097/WNR.0b013e32818b2a0b
3075:10.1016/0022-2836(77)90214-5
3063:Journal of Molecular Biology
3040:10.1016/0022-2836(77)90213-3
3028:Journal of Molecular Biology
3000:10.1016/j.biocel.2010.07.016
2879:10.1016/0896-6273(89)90210-9
2473:activity and is, along with
1932:insoluble aggregates called
780:phosphatidylinositol binding
705:lipoprotein particle binding
9249:Plakoglobin (gamma catenin)
7106:The Journal of Cell Biology
6857:10.1016/j.pnpbp.2006.04.007
6272:The Journal of Neuroscience
6223:The Journal of Neuroscience
5552:Kovács KA (December 2021).
3473:The Journal of Neuroscience
3113:The Journal of Neuroscience
1996:Although tau is present in
921:somatodendritic compartment
810:microtubule lateral binding
760:single-stranded DNA binding
755:double-stranded DNA binding
593:nucleus of stria terminalis
9551:
6111:10.1248/yakushi.18-00165-6
3593:10.1007/s00401-019-01970-9
3535:10.1186/s40478-021-01208-4
3326:10.1016/j.cell.2010.06.036
2927:10.1186/s13041-022-00935-6
2395:neurodegenerative diseases
2369:, pTau) can result in the
2355:
1795:Chr 11: 104.23 – 104.33 Mb
1217:microtubule polymerization
1027:microglial cell activation
9505:
7054:10.1016/j.nbd.2007.04.006
6962:10.1517/14728222.11.4.435
6882:Internal Medicine Journal
5088:10.1007/s12035-016-0299-z
4762:Frontiers in Neuroscience
4683:10.1186/s40478-019-0682-x
4642:10.1016/j.jmb.2018.12.008
4284:Journal of Neurochemistry
3914:10.1186/s40478-017-0489-6
2726:"Mouse PubMed Reference:"
2708:"Human PubMed Reference:"
2621:Corticobasal degeneration
1974:Microtubule stabilization
1833:
1828:
1824:
1817:
1801:
1782:
1663:
1598:
1567:
1536:
1491:
1460:
1447:
1443:
1428:
1424:
1415:
1402:
1398:
1375:
1371:
1362:
1349:
1345:
1330:
1326:
1317:
1302:
1295:
1291:
1275:
1077:cellular response to heat
785:identical protein binding
670:
666:
649:
626:
617:
604:
553:
544:
519:anterior cingulate cortex
491:
482:
452:
444:
440:
423:
410:
373:
352:
343:
339:
322:
309:
272:
249:
240:
236:
191:
188:
178:
171:
166:
79:
74:
57:
52:
47:
43:
39:
34:
9475:Prokaryotic cytoskeleton
7155:Medical Subject Headings
6923:Human Molecular Genetics
6481:Human Molecular Genetics
6475:Heutink P (April 2000).
6152:10.1074/jbc.274.36.25481
5626:Belluck P (2020-07-28).
5264:Experimental Gerontology
4911:Human Molecular Genetics
4775:10.3389/fnins.2017.00667
3425:10.15252/embj.2018101174
3215:Progress in Neurobiology
2433:(PHFs) in the AD brain.
2431:paired helical filaments
2365:of the tau protein (tau
1889:and are abundant in the
1788:Chr 17: 45.89 – 46.03 Mb
1257:amyloid fibril formation
951:microtubule cytoskeleton
735:receptor ligand activity
7166:MR scans of variant CJD
7042:Neurobiology of Disease
6403:Trends in Neurosciences
6176:Neuromolecular Medicine
6051:Bloom GS (April 2014).
5728:10.1001/jama.2020.12134
5477:10.1073/pnas.90.14.6825
5418:10.1074/jbc.M114.611368
5307:Trends in Neurosciences
5187:10.4103/0019-5545.44908
4437:10.1073/pnas.0400348101
4198:The Biochemical Journal
3874:10.3233/JAD-2010-100285
3778:10.1126/science.1141736
3630:Journal of Cell Science
3375:10.1186/gb-2004-6-1-204
2832:10.1073/pnas.85.11.4051
2533:frontotemporal dementia
2427:neurofibrillary tangles
2416:
2387:frontotemporal dementia
2346:neurofibrillary tangles
2251:serine/threonine kinase
1962:EnCor Biotechnology Inc
1934:neurofibrillary tangles
1207:stress granule assembly
1002:regulation of autophagy
7118:10.1083/jcb.107.4.1449
7081:Folia Neuropathologica
6718:Folia Neuropathologica
6578:Molecular Neurobiology
6375:10.1074/jbc.M003738200
5076:Molecular Neurobiology
5026:10.1073/pnas.121119298
4547:10.1074/jbc.M808759200
4260:10.1074/jbc.M007427200
3642:10.1242/jcs.114.6.1179
2773:10.1073/pnas.72.5.1858
2501:traumatic brain injury
2495:Traumatic brain injury
2441:action or exposure to
1965:
1895:central nervous system
1187:rRNA metabolic process
856:neurofibrillary tangle
770:protein kinase binding
685:apolipoprotein binding
561:lateral septal nucleus
495:superior frontal gyrus
407:11 67.79 cM|11 E1
8095:(hard alpha-keratins)
7926:(soft alpha-keratins)
6590:10.1385/MN:24:1-3:087
6440:Neurobiology of Aging
5766:. PBS Online by WGBH.
5233:10.1007/s004010100423
5221:Acta Neuropathologica
4496:10.1073/pnas.94.1.298
3581:Acta Neuropathologica
2356:Further information:
2352:Clinical significance
2180:alternatively spliced
1985:Other nervous system
1946:
997:generation of neurons
981:glial cell projection
745:Hsp90 protein binding
515:primary visual cortex
368:Chromosome 11 (mouse)
266:Chromosome 17 (human)
9510:cytoskeletal defects
9470:Major sperm proteins
7168:CSF tau-positive man
6188:10.1385/NMM:4:1-2:49
5936:10.1093/brain/awr286
5887:10.1093/brain/aws307
5678:10.1084/jem.20200861
5571:10.3390/ijms23010462
5367:10.3390/cells8030260
3715:Neuroscience Letters
2603:Dementia pugilistica
2471:alkaline phosphatase
2363:Hyperphosphorylation
2120:neuronal development
1868:alternative splicing
1172:response to lead ion
1092:synapse organization
1082:astrocyte activation
936:extracellular region
581:lateral hypothalamus
557:ventromedial nucleus
75:List of PDB id codes
48:Available structures
7923:Epithelial keratins
6494:10.1093/hmg/9.6.979
5608:The Free Dictionary
5468:1993PNAS...90.6825S
5017:2001PNAS...98.6923A
4813:Nature Neuroscience
4487:1997PNAS...94..298A
4428:2004PNAS..10110804L
4422:(29): 10804–10809.
4135:10.1038/hdy.2008.70
3770:2007Sci...316..750R
3275:10.1155/2012/873270
3173:1994Natur.369..488H
2823:1988PNAS...85.4051G
2764:1975PNAS...72.1858W
2608:Alzheimer's disease
2529:Alzheimer's disease
2482:hyperphosphorylated
2383:Alzheimer's disease
2116:cellular signalling
1930:hyperphosphorylated
1926:Parkinson's disease
1922:Alzheimer's disease
1167:cell-cell signaling
1037:signal transduction
725:microtubule binding
6932:10.1093/hmg/ddl190
6827:10.1042/BST0330582
6751:10.1002/humu.20086
5632:The New York Times
4923:10.1093/hmg/ddn326
4171:10.1042/BST0330582
3268:(873270): 873270.
2447:glycosaminoglycans
2230:with 79 potential
2170:21, containing 16
2080:and to facilitate
2062:ribosomal proteins
2025:signaling proteins
1966:
1953:immunofluorescence
1850:(abbreviated from
1405:ENSMUSG00000018411
990:Biological process
926:neuronal cell body
824:Cellular component
690:SH3 domain binding
678:Molecular function
527:hippocampus proper
503:right frontal lobe
9517:
9516:
9458:
9457:
9218:
9217:
8463:
8462:
8345:
8344:
7888:
7887:
7831:
7830:
6693:10.1159/000077150
6656:10.1159/000077149
6001:978-981-329-357-1
5930:(Pt 4): 1268–80.
5411:(49): 34389–407.
5137:10.4161/pri.19912
5082:(10): 7979–7993.
4756:Yamada K (2017).
4210:10.1042/bj3230577
3636:(Pt 6): 1179–87.
3119:(42): 8315–8329.
2509:American football
2310:entorhinal cortex
2089:fear conditioning
2055:protein synthesis
1897:(CNS), where the
1844:
1843:
1840:
1839:
1813:
1812:
1778:
1777:
1633:
1632:
1563:
1562:
1526:
1525:
1456:
1455:
1437:
1436:
1411:
1410:
1392:
1391:
1358:
1357:
1339:
1338:
1287:
1286:
961:neuron projection
846:nuclear periphery
800:chaperone binding
662:
661:
658:
657:
613:
612:
600:
599:
589:entorhinal cortex
569:perirhinal cortex
538:
537:
499:prefrontal cortex
436:
435:
335:
334:
162:
161:
158:
157:
58:Ortholog search:
16:(Redirected from
9542:
8479:
7919:
7901:
7262:
7253:
7239:
7217:
7210:
7203:
7194:
7139:
7129:
7096:
7075:
7065:
7032:
7014:
6981:
6944:
6934:
6913:
6876:
6838:
6809:
6799:
6770:
6733:
6712:
6675:
6638:
6609:
6572:
6563:(11): 1297–307.
6551:
6541:
6516:
6506:
6496:
6471:
6434:
6388:
6387:
6377:
6368:(33): 25247–54.
6353:
6347:
6346:
6336:
6312:
6306:
6305:
6295:
6263:
6257:
6256:
6246:
6214:
6208:
6207:
6171:
6165:
6164:
6154:
6130:
6124:
6123:
6113:
6104:(7): 1021–1025.
6089:
6083:
6082:
6072:
6048:
6042:
6041:
6035:
6031:
6029:
6021:
5979:
5973:
5970:
5957:
5947:
5915:
5909:
5908:
5898:
5866:
5860:
5859:
5849:
5832:(134): 134ra60.
5817:
5811:
5810:
5774:
5768:
5767:
5756:
5750:
5749:
5739:
5707:
5701:
5700:
5690:
5680:
5656:
5650:
5649:
5647:
5646:
5623:
5617:
5616:
5615:
5614:
5600:
5594:
5593:
5583:
5573:
5549:
5543:
5542:
5506:
5500:
5499:
5489:
5479:
5447:
5441:
5440:
5430:
5420:
5396:
5390:
5389:
5379:
5369:
5345:
5339:
5338:
5302:
5296:
5295:
5259:
5253:
5252:
5216:
5210:
5209:
5199:
5189:
5165:
5159:
5158:
5148:
5116:
5110:
5109:
5099:
5067:
5061:
5058:
5049:
5048:
5038:
5028:
4996:
4990:
4989:
4979:
4951:
4945:
4944:
4934:
4902:
4896:
4895:
4877:
4853:
4847:
4846:
4836:
4804:
4798:
4797:
4787:
4777:
4753:
4747:
4746:
4736:
4712:
4706:
4705:
4695:
4685:
4661:
4655:
4654:
4644:
4620:
4614:
4613:
4603:
4585:
4576:
4570:
4569:
4559:
4549:
4540:(19): 12845–52.
4525:
4519:
4518:
4508:
4498:
4466:
4460:
4459:
4449:
4439:
4407:
4401:
4400:
4363:
4357:
4356:
4346:
4322:
4316:
4315:
4279:
4273:
4272:
4262:
4253:(13): 10025–31.
4238:
4232:
4231:
4221:
4189:
4183:
4182:
4154:
4148:
4147:
4137:
4113:
4107:
4106:
4096:
4064:
4058:
4057:
4020:
4014:
4013:
4003:
3979:
3973:
3972:
3943:
3937:
3936:
3926:
3916:
3892:
3886:
3885:
3853:
3847:
3846:
3836:
3804:
3798:
3797:
3753:
3747:
3746:
3710:
3701:
3700:
3660:
3654:
3653:
3621:
3615:
3614:
3604:
3572:
3566:
3565:
3555:
3537:
3513:
3507:
3506:
3496:
3464:
3455:
3454:
3444:
3413:The EMBO Journal
3404:
3398:
3397:
3387:
3377:
3353:
3347:
3346:
3328:
3304:
3298:
3297:
3287:
3277:
3253:
3247:
3246:
3210:
3201:
3200:
3181:10.1038/369488a0
3167:(6480): 488–91.
3156:
3147:
3146:
3136:
3104:
3087:
3086:
3058:
3052:
3051:
3023:
3012:
3011:
2983:
2977:
2976:
2956:
2950:
2949:
2939:
2929:
2905:
2899:
2898:
2861:
2855:
2854:
2844:
2834:
2802:
2796:
2795:
2785:
2775:
2743:
2734:
2733:
2722:
2716:
2715:
2704:
2698:
2688:
2677:
2667:
2499:Repetitive mild
2459:axonal transport
2302:macropinocytosis
2223:carboxy-terminus
2100:sleep-wake cycle
2078:long-term memory
2035:mRNA translation
2027:and to regulate
1912:Pathologies and
1907:oligodendrocytes
1864:protein isoforms
1826:
1825:
1797:
1790:
1773:
1637:
1628:
1572:
1568:RefSeq (protein)
1558:
1530:
1521:
1465:
1441:
1422:
1396:
1369:
1343:
1324:
1293:
1227:axon development
1122:axonal transport
730:dynactin binding
668:
654:
645:
638:
631:
624:
609:
549:
547:Top expressed in
542:
487:
485:Top expressed in
480:
459:
442:
432:
419:
408:
393:
386:
380:
369:
357:
341:
331:
318:
307:
292:
285:
279:
268:
254:
238:
232:
230:MAPT - orthologs
183:
176:
153:
72:
66:
45:
44:
32:
21:
9550:
9549:
9545:
9544:
9543:
9541:
9540:
9539:
9520:
9519:
9518:
9513:
9501:
9454:
9357:
9263:
9214:
9127:
9106:
9058:
8881:
8673:
8625:
8471:
8459:
8429:
8376:
8341:
8325:
8209:Ungrouped alpha
8204:
8094:
8086:
7925:
7911:
7905:
7895:
7884:
7827:
7624:
7303:
7245:
7230:
7221:
7147:
7142:
7099:
7078:
7035:
6991:Brain Pathology
6984:
6947:
6916:
6879:
6841:
6821:(Pt 4): 582–5.
6812:
6773:
6736:
6715:
6678:
6641:
6612:
6575:
6554:
6519:
6474:
6437:
6400:
6396:
6394:Further reading
6391:
6355:
6354:
6350:
6327:(12): 5876–83.
6314:
6313:
6309:
6265:
6264:
6260:
6216:
6215:
6211:
6173:
6172:
6168:
6145:(36): 25481–9.
6132:
6131:
6127:
6098:Yakugaku Zasshi
6091:
6090:
6086:
6050:
6049:
6045:
6032:
6022:
6002:
5981:
5980:
5976:
5960:
5917:
5916:
5912:
5881:(Pt 1): 43–64.
5868:
5867:
5863:
5819:
5818:
5814:
5776:
5775:
5771:
5758:
5757:
5753:
5709:
5708:
5704:
5658:
5657:
5653:
5644:
5642:
5625:
5624:
5620:
5612:
5610:
5602:
5601:
5597:
5551:
5550:
5546:
5517:(1–2): 127–35.
5508:
5507:
5503:
5449:
5448:
5444:
5398:
5397:
5393:
5347:
5346:
5342:
5304:
5303:
5299:
5261:
5260:
5256:
5218:
5217:
5213:
5167:
5166:
5162:
5118:
5117:
5113:
5069:
5068:
5064:
5059:
5052:
4998:
4997:
4993:
4953:
4952:
4948:
4904:
4903:
4899:
4855:
4854:
4850:
4825:10.1038/nn.4132
4819:(11): 1584–93.
4806:
4805:
4801:
4755:
4754:
4750:
4714:
4713:
4709:
4663:
4662:
4658:
4622:
4621:
4617:
4583:
4578:
4577:
4573:
4527:
4526:
4522:
4468:
4467:
4463:
4409:
4408:
4404:
4375:(4): 989–1002.
4365:
4364:
4360:
4337:(49): 30981–7.
4324:
4323:
4319:
4281:
4280:
4276:
4240:
4239:
4235:
4191:
4190:
4186:
4165:(Pt 4): 582–5.
4156:
4155:
4151:
4115:
4114:
4110:
4073:Nature Genetics
4066:
4065:
4061:
4026:Nature Genetics
4022:
4021:
4017:
3994:(2–3): 179–97.
3981:
3980:
3976:
3945:
3944:
3940:
3894:
3893:
3889:
3855:
3854:
3850:
3806:
3805:
3801:
3764:(5825): 750–4.
3755:
3754:
3750:
3712:
3711:
3704:
3675:(10): 1049–52.
3662:
3661:
3657:
3623:
3622:
3618:
3574:
3573:
3569:
3515:
3514:
3510:
3466:
3465:
3458:
3419:(13): e101174.
3406:
3405:
3401:
3355:
3354:
3350:
3306:
3305:
3301:
3255:
3254:
3250:
3212:
3211:
3204:
3158:
3157:
3150:
3106:
3105:
3090:
3060:
3059:
3055:
3025:
3024:
3015:
2985:
2984:
2980:
2958:
2957:
2953:
2914:Molecular Brain
2907:
2906:
2902:
2863:
2862:
2858:
2804:
2803:
2799:
2745:
2744:
2737:
2724:
2723:
2719:
2706:
2705:
2701:
2689:
2680:
2668:
2659:
2655:
2650:
2592:
2560:Alpha-synuclein
2549:
2521:
2497:
2419:
2360:
2354:
2342:phosphoepitopes
2326:
2294:
2285:
2267:dephosphorylate
2215:
2188:N-terminal part
2162:In humans, the
2160:
2124:neuroprotection
2112:
2110:Other functions
2074:
2037:
2018:phosphorylation
1976:
1971:
1899:cerebral cortex
1835:View/Edit Mouse
1830:View/Edit Human
1793:
1786:
1783:Location (UCSC)
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1685:
1681:
1677:
1673:
1669:
1665:
1659:
1655:
1651:
1647:
1643:
1624:
1620:
1616:
1612:
1608:
1604:
1600:
1594:
1590:
1586:
1582:
1578:
1554:
1550:
1546:
1542:
1538:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1487:
1483:
1479:
1475:
1471:
1386:ENSG00000277956
1384:
1382:ENSG00000276155
1380:
1378:ENSG00000186868
1271:
985:
966:dendritic spine
866:tubulin complex
861:plasma membrane
841:cell projection
819:
700:protein binding
695:tubulin binding
650:
640:
639:
633:
632:
605:
596:
591:
587:
583:
579:
575:
573:mammillary body
571:
567:
563:
559:
545:
534:
529:
525:
521:
517:
513:
511:Brodmann area 9
509:
505:
501:
497:
483:
427:
414:
406:
396:
395:
394:
387:
367:
344:Gene location (
326:
313:
305:
295:
294:
293:
286:
264:
241:Gene location (
192:
179:
172:
81:
59:
28:
23:
22:
15:
12:
11:
5:
9548:
9546:
9538:
9537:
9532:
9522:
9521:
9515:
9514:
9506:
9503:
9502:
9500:
9499:
9498:
9497:
9492:
9487:
9482:
9472:
9466:
9464:
9460:
9459:
9456:
9455:
9453:
9452:
9447:
9442:
9441:
9440:
9435:
9425:
9420:
9419:
9418:
9408:
9407:
9406:
9401:
9396:
9391:
9386:
9381:
9376:
9374:Corneodesmosin
9365:
9363:
9359:
9358:
9356:
9355:
9354:
9353:
9348:
9343:
9338:
9333:
9328:
9323:
9313:
9312:
9311:
9306:
9301:
9291:
9286:
9285:
9284:
9273:
9271:
9265:
9264:
9262:
9261:
9256:
9251:
9246:
9245:
9244:
9234:
9228:
9226:
9220:
9219:
9216:
9215:
9213:
9212:
9211:
9210:
9205:
9200:
9190:
9189:
9188:
9183:
9178:
9173:
9168:
9158:
9153:
9152:
9151:
9141:
9135:
9133:
9129:
9128:
9126:
9125:
9120:
9114:
9112:
9108:
9107:
9105:
9104:
9099:
9094:
9089:
9084:
9079:
9074:
9068:
9066:
9060:
9059:
9057:
9056:
9051:
9046:
9041:
9036:
9031:
9026:
9021:
9016:
9011:
9006:
9001:
8996:
8989:
8988:
8983:
8978:
8973:
8968:
8963:
8958:
8953:
8948:
8943:
8938:
8933:
8928:
8923:
8918:
8913:
8908:
8903:
8898:
8891:
8889:
8883:
8882:
8880:
8879:
8874:
8869:
8864:
8859:
8854:
8849:
8844:
8839:
8834:
8829:
8824:
8819:
8814:
8809:
8804:
8799:
8794:
8789:
8784:
8779:
8774:
8769:
8764:
8759:
8754:
8749:
8744:
8739:
8734:
8729:
8724:
8719:
8714:
8709:
8704:
8699:
8694:
8689:
8683:
8681:
8675:
8674:
8672:
8671:
8666:
8661:
8656:
8651:
8646:
8641:
8635:
8633:
8627:
8626:
8624:
8623:
8618:
8613:
8608:
8603:
8598:
8593:
8588:
8583:
8578:
8573:
8568:
8563:
8558:
8553:
8548:
8543:
8538:
8533:
8528:
8523:
8518:
8513:
8508:
8503:
8498:
8493:
8487:
8485:
8476:
8465:
8464:
8461:
8460:
8458:
8457:
8452:
8447:
8441:Nuclear lamins
8437:
8435:
8431:
8430:
8428:
8427:
8422:
8417:
8416:
8415:
8410:
8405:
8395:
8390:
8384:
8382:
8378:
8377:
8375:
8374:
8369:
8364:
8359:
8353:
8351:
8347:
8346:
8343:
8342:
8340:
8339:
8333:
8331:
8327:
8326:
8324:
8323:
8322:
8321:
8316:
8311:
8306:
8301:
8296:
8291:
8286:
8281:
8276:
8263:
8262:
8261:
8260:
8255:
8250:
8245:
8240:
8235:
8230:
8225:
8212:
8210:
8206:
8205:
8203:
8202:
8201:
8200:
8195:
8190:
8185:
8180:
8175:
8158:
8157:
8156:
8155:
8150:
8145:
8140:
8135:
8130:
8125:
8120:
8115:
8098:
8096:
8088:
8087:
8085:
8084:
8083:
8082:
8077:
8072:
8067:
8062:
8057:
8052:
8047:
8042:
8037:
8020:
8019:
8018:
8017:
8007:
8006:
8005:
7993:
7992:
7991:
7986:
7981:
7976:
7971:
7966:
7961:
7956:
7951:
7946:
7929:
7927:
7916:
7898:
7890:
7889:
7886:
7885:
7883:
7882:
7877:
7872:
7871:
7870:
7865:
7860:
7850:
7845:
7839:
7837:
7833:
7832:
7829:
7828:
7826:
7825:
7820:
7819:
7818:
7813:
7803:
7798:
7797:
7796:
7791:
7790:
7789:
7784:
7767:
7765:Arp2/3 complex
7762:
7761:
7760:
7755:
7750:
7745:
7734:
7733:
7732:
7731:
7726:
7721:
7716:
7706:
7705:
7704:
7690:
7679:
7660:
7659:
7658:
7653:
7648:
7643:
7632:
7630:
7626:
7625:
7623:
7622:
7621:
7620:
7615:
7610:
7605:
7600:
7595:
7590:
7585:
7580:
7575:
7570:
7565:
7560:
7550:
7549:
7548:
7543:
7535:
7534:
7533:
7525:
7524:
7523:
7515:
7514:
7513:
7508:
7500:
7499:
7498:
7493:
7485:
7484:
7483:
7475:
7474:
7473:
7468:
7463:
7455:
7454:
7453:
7448:
7440:
7439:
7438:
7433:
7428:
7423:
7418:
7413:
7408:
7403:
7398:
7393:
7388:
7383:
7378:
7373:
7368:
7360:
7359:
7358:
7352:
7347:
7342:
7337:
7332:
7327:
7322:
7313:
7311:
7305:
7304:
7302:
7301:
7296:
7291:
7286:
7281:
7276:
7270:
7268:
7259:
7250:
7243:Microfilaments
7236:
7232:
7231:
7222:
7220:
7219:
7212:
7205:
7197:
7191:
7190:
7169:
7163:
7158:
7146:
7145:External links
7143:
7141:
7140:
7112:(4): 1449–59.
7097:
7076:
7033:
6982:
6945:
6914:
6888:(10): 652–60.
6877:
6851:(8): 1369–80.
6839:
6810:
6771:
6739:Human Mutation
6734:
6713:
6676:
6639:
6621:(12): 555–62.
6610:
6584:(1–3): 87–97.
6573:
6552:
6517:
6472:
6435:
6397:
6395:
6392:
6390:
6389:
6348:
6307:
6258:
6229:(3): 698–707.
6209:
6182:(1–2): 49–58.
6166:
6125:
6084:
6063:(4): 505–508.
6057:JAMA Neurology
6043:
6034:|journal=
6000:
5974:
5972:
5971:
5910:
5861:
5812:
5769:
5760:"Brain Trauma"
5751:
5722:(8): 772–781.
5702:
5651:
5618:
5595:
5544:
5511:Brain Research
5501:
5462:(14): 6825–8.
5442:
5391:
5340:
5297:
5254:
5211:
5160:
5111:
5062:
5050:
5011:(12): 6923–8.
4991:
4946:
4897:
4848:
4799:
4748:
4727:(1): 189–210.
4707:
4656:
4635:(4): 687–695.
4615:
4594:(8): 1176–83.
4571:
4520:
4481:(1): 298–303.
4461:
4402:
4358:
4317:
4290:(5): 1667–75.
4274:
4233:
4184:
4149:
4108:
4085:10.1038/ng.193
4079:(9): 1076–83.
4059:
4038:10.1038/ng1858
4015:
3974:
3949:Brain Research
3938:
3887:
3848:
3799:
3748:
3702:
3655:
3616:
3587:(4): 571–583.
3567:
3508:
3456:
3399:
3362:Genome Biology
3348:
3299:
3248:
3202:
3148:
3088:
3053:
3013:
2994:(11): 1775–8.
2978:
2967:(5): 693–702.
2951:
2900:
2856:
2817:(11): 4051–5.
2797:
2758:(5): 1858–62.
2735:
2717:
2699:
2678:
2656:
2654:
2651:
2649:
2648:
2643:
2638:
2636:Pick's disease
2633:
2628:
2623:
2618:
2615:
2610:
2605:
2600:
2593:
2591:
2588:
2587:
2586:
2580:
2574:
2569:
2563:
2548:
2545:
2520:
2517:
2505:contact sports
2496:
2493:
2423:tau hypothesis
2418:
2415:
2353:
2350:
2325:
2322:
2293:
2290:
2284:
2281:
2228:phosphoprotein
2214:
2211:
2168:chromosome 17q
2159:
2156:
2148:chronic stress
2111:
2108:
2073:
2070:
2036:
2033:
1975:
1972:
1970:
1967:
1918:nervous system
1842:
1841:
1838:
1837:
1832:
1822:
1821:
1815:
1814:
1811:
1810:
1808:
1806:
1799:
1798:
1791:
1784:
1780:
1779:
1776:
1775:
1661:
1660:
1634:
1631:
1630:
1596:
1595:
1569:
1565:
1564:
1561:
1560:
1534:
1533:
1527:
1524:
1523:
1489:
1488:
1462:
1458:
1457:
1454:
1453:
1445:
1444:
1438:
1435:
1434:
1426:
1425:
1419:
1413:
1412:
1409:
1408:
1400:
1399:
1393:
1390:
1389:
1373:
1372:
1366:
1360:
1359:
1356:
1355:
1347:
1346:
1340:
1337:
1336:
1328:
1327:
1321:
1315:
1314:
1309:
1304:
1300:
1299:
1289:
1288:
1285:
1284:
1273:
1272:
1270:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
993:
991:
987:
986:
984:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
931:axon cytoplasm
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
827:
825:
821:
820:
818:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
710:enzyme binding
707:
702:
697:
692:
687:
681:
679:
675:
674:
664:
663:
660:
659:
656:
655:
647:
646:
621:
615:
614:
611:
610:
602:
601:
598:
597:
595:
594:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
551:
550:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
476:
475:
467:
456:
450:
449:
446:RNA expression
438:
437:
434:
433:
425:
421:
420:
412:
409:
404:
398:
397:
388:
381:
375:
371:
370:
365:
359:
358:
350:
349:
337:
336:
333:
332:
324:
320:
319:
311:
308:
303:
297:
296:
287:
280:
274:
270:
269:
262:
256:
255:
247:
246:
234:
233:
190:
186:
185:
177:
169:
168:
164:
163:
160:
159:
156:
155:
77:
76:
68:
67:
56:
50:
49:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
9547:
9536:
9533:
9531:
9528:
9527:
9525:
9512:
9511:
9504:
9496:
9493:
9491:
9488:
9486:
9483:
9481:
9478:
9477:
9476:
9473:
9471:
9468:
9467:
9465:
9461:
9451:
9448:
9446:
9443:
9439:
9436:
9434:
9431:
9430:
9429:
9426:
9424:
9421:
9417:
9414:
9413:
9412:
9409:
9405:
9402:
9400:
9397:
9395:
9392:
9390:
9387:
9385:
9382:
9380:
9377:
9375:
9372:
9371:
9370:
9367:
9366:
9364:
9360:
9352:
9349:
9347:
9344:
9342:
9339:
9337:
9334:
9332:
9329:
9327:
9324:
9322:
9319:
9318:
9317:
9314:
9310:
9307:
9305:
9302:
9300:
9297:
9296:
9295:
9292:
9290:
9287:
9283:
9280:
9279:
9278:
9275:
9274:
9272:
9270:
9266:
9260:
9257:
9255:
9254:Delta catenin
9252:
9250:
9247:
9243:
9240:
9239:
9238:
9235:
9233:
9232:Alpha catenin
9230:
9229:
9227:
9225:
9221:
9209:
9206:
9204:
9201:
9199:
9196:
9195:
9194:
9191:
9187:
9184:
9182:
9179:
9177:
9174:
9172:
9169:
9167:
9164:
9163:
9162:
9159:
9157:
9154:
9150:
9147:
9146:
9145:
9142:
9140:
9137:
9136:
9134:
9130:
9124:
9121:
9119:
9116:
9115:
9113:
9109:
9103:
9100:
9098:
9095:
9093:
9090:
9088:
9085:
9083:
9080:
9078:
9075:
9073:
9070:
9069:
9067:
9065:
9061:
9055:
9052:
9050:
9047:
9045:
9042:
9040:
9037:
9035:
9032:
9030:
9027:
9025:
9022:
9020:
9017:
9015:
9012:
9010:
9007:
9005:
9002:
9000:
8997:
8995:
8992:cytoplasmic:
8991:
8990:
8987:
8984:
8982:
8979:
8977:
8974:
8972:
8969:
8967:
8964:
8962:
8959:
8957:
8954:
8952:
8949:
8947:
8944:
8942:
8939:
8937:
8934:
8932:
8929:
8927:
8924:
8922:
8919:
8917:
8914:
8912:
8909:
8907:
8904:
8902:
8899:
8897:
8893:
8892:
8890:
8888:
8884:
8878:
8875:
8873:
8870:
8868:
8865:
8863:
8860:
8858:
8855:
8853:
8850:
8848:
8845:
8843:
8840:
8838:
8835:
8833:
8830:
8828:
8825:
8823:
8820:
8818:
8815:
8813:
8810:
8808:
8805:
8803:
8800:
8798:
8795:
8793:
8790:
8788:
8785:
8783:
8780:
8778:
8775:
8773:
8770:
8768:
8765:
8763:
8760:
8758:
8755:
8753:
8750:
8748:
8745:
8743:
8740:
8738:
8735:
8733:
8730:
8728:
8725:
8723:
8720:
8718:
8715:
8713:
8710:
8708:
8705:
8703:
8700:
8698:
8695:
8693:
8690:
8688:
8685:
8684:
8682:
8680:
8676:
8670:
8667:
8665:
8662:
8660:
8657:
8655:
8652:
8650:
8647:
8645:
8642:
8640:
8637:
8636:
8634:
8632:
8628:
8622:
8619:
8617:
8614:
8612:
8609:
8607:
8604:
8602:
8599:
8597:
8594:
8592:
8589:
8587:
8584:
8582:
8579:
8577:
8574:
8572:
8569:
8567:
8564:
8562:
8559:
8557:
8554:
8552:
8549:
8547:
8544:
8542:
8539:
8537:
8534:
8532:
8529:
8527:
8524:
8522:
8519:
8517:
8514:
8512:
8509:
8507:
8504:
8502:
8499:
8497:
8494:
8492:
8489:
8488:
8486:
8484:
8480:
8477:
8475:
8470:
8466:
8456:
8453:
8451:
8448:
8446:
8442:
8439:
8438:
8436:
8432:
8426:
8423:
8421:
8418:
8414:
8411:
8409:
8406:
8404:
8401:
8400:
8399:
8398:Neurofilament
8396:
8394:
8391:
8389:
8386:
8385:
8383:
8379:
8373:
8370:
8368:
8365:
8363:
8360:
8358:
8355:
8354:
8352:
8348:
8338:
8335:
8334:
8332:
8328:
8320:
8317:
8315:
8312:
8310:
8307:
8305:
8302:
8300:
8297:
8295:
8292:
8290:
8287:
8285:
8282:
8280:
8277:
8275:
8272:
8271:
8270:
8269:
8268:chromosome 12
8265:
8264:
8259:
8256:
8254:
8251:
8249:
8246:
8244:
8241:
8239:
8236:
8234:
8231:
8229:
8226:
8224:
8221:
8220:
8219:
8218:
8217:chromosome 17
8214:
8213:
8211:
8207:
8199:
8196:
8194:
8191:
8189:
8186:
8184:
8181:
8179:
8176:
8174:
8171:
8170:
8169:
8168:
8167:chromosome 12
8164:
8160:
8159:
8154:
8151:
8149:
8146:
8144:
8141:
8139:
8136:
8134:
8131:
8129:
8126:
8124:
8121:
8119:
8116:
8114:
8111:
8110:
8109:
8108:
8107:chromosome 17
8104:
8100:
8099:
8097:
8093:
8092:Hair keratins
8089:
8081:
8078:
8076:
8073:
8071:
8068:
8066:
8063:
8061:
8058:
8056:
8053:
8051:
8048:
8046:
8043:
8041:
8038:
8036:
8033:
8032:
8031:
8030:
8029:chromosome 12
8026:
8022:
8021:
8016:
8013:
8012:
8011:
8008:
8004:
8001:
8000:
7999:
7998:
7997:chromosome 12
7994:
7990:
7987:
7985:
7982:
7980:
7977:
7975:
7972:
7970:
7967:
7965:
7962:
7960:
7957:
7955:
7952:
7950:
7947:
7945:
7942:
7941:
7940:
7939:
7938:chromosome 17
7935:
7931:
7930:
7928:
7924:
7920:
7917:
7914:
7909:
7902:
7899:
7897:
7894:Intermediate
7891:
7881:
7878:
7876:
7873:
7869:
7866:
7864:
7861:
7859:
7856:
7855:
7854:
7851:
7849:
7846:
7844:
7841:
7840:
7838:
7834:
7824:
7821:
7817:
7814:
7812:
7809:
7808:
7807:
7804:
7802:
7799:
7795:
7792:
7788:
7785:
7783:
7780:
7779:
7778:
7775:
7774:
7773:
7772:
7768:
7766:
7763:
7759:
7756:
7754:
7751:
7749:
7746:
7744:
7741:
7740:
7739:
7736:
7735:
7730:
7727:
7725:
7722:
7720:
7717:
7715:
7712:
7711:
7710:
7707:
7703:
7700:
7697:
7694:
7691:
7689:
7686:
7683:
7680:
7678:
7675:
7672:
7669:
7666:
7665:
7664:
7661:
7657:
7654:
7652:
7649:
7647:
7644:
7642:
7639:
7638:
7637:
7634:
7633:
7631:
7627:
7619:
7616:
7614:
7611:
7609:
7606:
7604:
7601:
7599:
7596:
7594:
7591:
7589:
7586:
7584:
7581:
7579:
7576:
7574:
7571:
7569:
7566:
7564:
7561:
7559:
7556:
7555:
7554:
7551:
7547:
7544:
7542:
7539:
7538:
7536:
7532:
7529:
7528:
7526:
7522:
7519:
7518:
7516:
7512:
7509:
7507:
7504:
7503:
7501:
7497:
7494:
7492:
7489:
7488:
7486:
7482:
7479:
7478:
7476:
7472:
7469:
7467:
7464:
7462:
7459:
7458:
7456:
7452:
7449:
7447:
7444:
7443:
7441:
7437:
7434:
7432:
7429:
7427:
7424:
7422:
7419:
7417:
7414:
7412:
7409:
7407:
7404:
7402:
7399:
7397:
7394:
7392:
7389:
7387:
7384:
7382:
7379:
7377:
7374:
7372:
7369:
7367:
7364:
7363:
7361:
7356:
7353:
7351:
7348:
7346:
7343:
7341:
7338:
7336:
7333:
7331:
7328:
7326:
7323:
7321:
7318:
7317:
7315:
7314:
7312:
7310:
7306:
7300:
7297:
7295:
7292:
7290:
7287:
7285:
7282:
7280:
7277:
7275:
7272:
7271:
7269:
7267:
7263:
7260:
7258:
7254:
7251:
7249:
7244:
7240:
7237:
7233:
7229:
7225:
7218:
7213:
7211:
7206:
7204:
7199:
7198:
7195:
7188:
7184:
7183:
7178:
7174:
7170:
7167:
7164:
7162:
7159:
7156:
7152:
7149:
7148:
7144:
7137:
7133:
7128:
7123:
7119:
7115:
7111:
7107:
7103:
7098:
7094:
7090:
7087:(4): 244–57.
7086:
7082:
7077:
7073:
7069:
7064:
7059:
7055:
7051:
7047:
7043:
7039:
7034:
7030:
7026:
7022:
7018:
7013:
7008:
7004:
7000:
6996:
6992:
6988:
6983:
6979:
6975:
6971:
6967:
6963:
6959:
6956:(4): 435–42.
6955:
6951:
6946:
6942:
6938:
6933:
6928:
6924:
6920:
6915:
6911:
6907:
6903:
6899:
6895:
6891:
6887:
6883:
6878:
6874:
6870:
6866:
6862:
6858:
6854:
6850:
6846:
6840:
6836:
6832:
6828:
6824:
6820:
6816:
6811:
6807:
6803:
6798:
6793:
6789:
6785:
6781:
6777:
6772:
6768:
6764:
6760:
6756:
6752:
6748:
6745:(4): 277–95.
6744:
6740:
6735:
6731:
6727:
6724:(2): 119–23.
6723:
6719:
6714:
6710:
6706:
6702:
6698:
6694:
6690:
6686:
6682:
6677:
6673:
6669:
6665:
6661:
6657:
6653:
6650:(4): 258–60.
6649:
6645:
6640:
6636:
6632:
6628:
6624:
6620:
6616:
6611:
6607:
6603:
6599:
6595:
6591:
6587:
6583:
6579:
6574:
6570:
6566:
6562:
6558:
6553:
6549:
6545:
6540:
6535:
6532:(1): 110–21.
6531:
6527:
6523:
6518:
6514:
6510:
6505:
6500:
6495:
6490:
6487:(6): 979–86.
6486:
6482:
6478:
6473:
6469:
6465:
6461:
6457:
6453:
6449:
6445:
6441:
6436:
6432:
6428:
6424:
6420:
6416:
6412:
6408:
6404:
6399:
6398:
6393:
6385:
6381:
6376:
6371:
6367:
6363:
6359:
6352:
6349:
6344:
6340:
6335:
6330:
6326:
6322:
6318:
6311:
6308:
6303:
6299:
6294:
6289:
6285:
6281:
6278:(7): 2240–6.
6277:
6273:
6269:
6262:
6259:
6254:
6250:
6245:
6240:
6236:
6232:
6228:
6224:
6220:
6213:
6210:
6205:
6201:
6197:
6193:
6189:
6185:
6181:
6177:
6170:
6167:
6162:
6158:
6153:
6148:
6144:
6140:
6136:
6129:
6126:
6121:
6117:
6112:
6107:
6103:
6099:
6095:
6088:
6085:
6080:
6076:
6071:
6066:
6062:
6058:
6054:
6047:
6044:
6039:
6027:
6019:
6015:
6011:
6007:
6003:
5997:
5993:
5989:
5985:
5978:
5975:
5968:
5964:
5959:
5958:
5955:
5951:
5946:
5941:
5937:
5933:
5929:
5925:
5921:
5914:
5911:
5906:
5902:
5897:
5892:
5888:
5884:
5880:
5876:
5872:
5865:
5862:
5857:
5853:
5848:
5843:
5839:
5835:
5831:
5827:
5823:
5816:
5813:
5808:
5804:
5800:
5796:
5792:
5788:
5784:
5780:
5773:
5770:
5765:
5761:
5755:
5752:
5747:
5743:
5738:
5733:
5729:
5725:
5721:
5717:
5713:
5706:
5703:
5698:
5694:
5689:
5684:
5679:
5674:
5670:
5666:
5662:
5655:
5652:
5641:
5637:
5633:
5629:
5622:
5619:
5609:
5605:
5599:
5596:
5591:
5587:
5582:
5577:
5572:
5567:
5563:
5559:
5555:
5548:
5545:
5540:
5536:
5532:
5528:
5524:
5520:
5516:
5512:
5505:
5502:
5497:
5493:
5488:
5483:
5478:
5473:
5469:
5465:
5461:
5457:
5453:
5446:
5443:
5438:
5434:
5429:
5424:
5419:
5414:
5410:
5406:
5402:
5395:
5392:
5387:
5383:
5378:
5373:
5368:
5363:
5359:
5355:
5351:
5344:
5341:
5336:
5332:
5328:
5324:
5320:
5316:
5312:
5308:
5301:
5298:
5293:
5289:
5285:
5281:
5277:
5273:
5270:(4): 461–71.
5269:
5265:
5258:
5255:
5250:
5246:
5242:
5238:
5234:
5230:
5226:
5222:
5215:
5212:
5207:
5203:
5198:
5193:
5188:
5183:
5179:
5175:
5171:
5164:
5161:
5156:
5152:
5147:
5142:
5138:
5134:
5131:(3): 223–33.
5130:
5126:
5122:
5115:
5112:
5107:
5103:
5098:
5093:
5089:
5085:
5081:
5077:
5073:
5066:
5063:
5057:
5055:
5051:
5046:
5042:
5037:
5032:
5027:
5022:
5018:
5014:
5010:
5006:
5002:
4995:
4992:
4987:
4983:
4978:
4973:
4969:
4965:
4961:
4957:
4950:
4947:
4942:
4938:
4933:
4928:
4924:
4920:
4917:(1): 164–77.
4916:
4912:
4908:
4901:
4898:
4893:
4889:
4885:
4881:
4876:
4871:
4868:(5): 671–82.
4867:
4863:
4859:
4852:
4849:
4844:
4840:
4835:
4830:
4826:
4822:
4818:
4814:
4810:
4803:
4800:
4795:
4791:
4786:
4781:
4776:
4771:
4767:
4763:
4759:
4752:
4749:
4744:
4740:
4735:
4730:
4726:
4722:
4718:
4711:
4708:
4703:
4699:
4694:
4689:
4684:
4679:
4675:
4671:
4667:
4660:
4657:
4652:
4648:
4643:
4638:
4634:
4630:
4626:
4619:
4616:
4611:
4607:
4602:
4597:
4593:
4589:
4582:
4575:
4572:
4567:
4563:
4558:
4553:
4548:
4543:
4539:
4535:
4531:
4524:
4521:
4516:
4512:
4507:
4502:
4497:
4492:
4488:
4484:
4480:
4476:
4472:
4465:
4462:
4457:
4453:
4448:
4443:
4438:
4433:
4429:
4425:
4421:
4417:
4413:
4406:
4403:
4398:
4394:
4390:
4386:
4382:
4378:
4374:
4370:
4362:
4359:
4354:
4350:
4345:
4340:
4336:
4332:
4328:
4321:
4318:
4313:
4309:
4305:
4301:
4297:
4293:
4289:
4285:
4278:
4275:
4270:
4266:
4261:
4256:
4252:
4248:
4244:
4237:
4234:
4229:
4225:
4220:
4215:
4211:
4207:
4204:(3): 577–91.
4203:
4199:
4195:
4188:
4185:
4180:
4176:
4172:
4168:
4164:
4160:
4153:
4150:
4145:
4141:
4136:
4131:
4127:
4123:
4119:
4112:
4109:
4104:
4100:
4095:
4090:
4086:
4082:
4078:
4074:
4070:
4063:
4060:
4055:
4051:
4047:
4043:
4039:
4035:
4032:(9): 1032–7.
4031:
4027:
4019:
4016:
4011:
4007:
4002:
3997:
3993:
3989:
3985:
3978:
3975:
3970:
3966:
3962:
3958:
3955:(3): 271–80.
3954:
3950:
3942:
3939:
3934:
3930:
3925:
3920:
3915:
3910:
3906:
3902:
3898:
3891:
3888:
3883:
3879:
3875:
3871:
3868:(2): 411–21.
3867:
3863:
3859:
3852:
3849:
3844:
3840:
3835:
3830:
3826:
3822:
3819:(1): 516–31.
3818:
3814:
3810:
3803:
3800:
3795:
3791:
3787:
3783:
3779:
3775:
3771:
3767:
3763:
3759:
3752:
3749:
3744:
3740:
3736:
3732:
3728:
3724:
3721:(3): 129–32.
3720:
3716:
3709:
3707:
3703:
3698:
3694:
3690:
3686:
3682:
3678:
3674:
3670:
3666:
3659:
3656:
3651:
3647:
3643:
3639:
3635:
3631:
3627:
3620:
3617:
3612:
3608:
3603:
3598:
3594:
3590:
3586:
3582:
3578:
3571:
3568:
3563:
3559:
3554:
3549:
3545:
3541:
3536:
3531:
3527:
3523:
3519:
3512:
3509:
3504:
3500:
3495:
3490:
3486:
3482:
3479:(3): 1001–7.
3478:
3474:
3470:
3463:
3461:
3457:
3452:
3448:
3443:
3438:
3434:
3430:
3426:
3422:
3418:
3414:
3410:
3403:
3400:
3395:
3391:
3386:
3381:
3376:
3371:
3367:
3363:
3359:
3352:
3349:
3344:
3340:
3336:
3332:
3327:
3322:
3319:(3): 387–97.
3318:
3314:
3310:
3303:
3300:
3295:
3291:
3286:
3281:
3276:
3271:
3267:
3263:
3259:
3252:
3249:
3244:
3240:
3236:
3232:
3228:
3224:
3221:(2): 148–75.
3220:
3216:
3209:
3207:
3203:
3198:
3194:
3190:
3186:
3182:
3178:
3174:
3170:
3166:
3162:
3155:
3153:
3149:
3144:
3140:
3135:
3130:
3126:
3122:
3118:
3114:
3110:
3103:
3101:
3099:
3097:
3095:
3093:
3089:
3084:
3080:
3076:
3072:
3069:(2): 227–47.
3068:
3064:
3057:
3054:
3049:
3045:
3041:
3037:
3034:(2): 207–25.
3033:
3029:
3022:
3020:
3018:
3014:
3009:
3005:
3001:
2997:
2993:
2989:
2982:
2979:
2974:
2970:
2966:
2962:
2955:
2952:
2947:
2943:
2938:
2933:
2928:
2923:
2919:
2915:
2911:
2904:
2901:
2896:
2892:
2888:
2884:
2880:
2876:
2873:(4): 519–26.
2872:
2868:
2860:
2857:
2852:
2848:
2843:
2838:
2833:
2828:
2824:
2820:
2816:
2812:
2808:
2801:
2798:
2793:
2789:
2784:
2779:
2774:
2769:
2765:
2761:
2757:
2753:
2749:
2742:
2740:
2736:
2731:
2727:
2721:
2718:
2713:
2709:
2703:
2700:
2696:
2692:
2687:
2685:
2683:
2679:
2675:
2671:
2666:
2664:
2662:
2658:
2652:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2598:
2595:
2594:
2589:
2584:
2581:
2578:
2575:
2573:
2570:
2567:
2564:
2561:
2558:
2557:
2556:
2554:
2546:
2544:
2542:
2538:
2534:
2530:
2526:
2518:
2516:
2514:
2510:
2507:, especially
2506:
2502:
2494:
2492:
2490:
2485:
2483:
2478:
2476:
2472:
2468:
2462:
2460:
2456:
2452:
2448:
2444:
2440:
2434:
2432:
2428:
2424:
2414:
2412:
2406:
2404:
2400:
2396:
2392:
2388:
2384:
2380:
2376:
2372:
2371:self-assembly
2368:
2364:
2359:
2351:
2349:
2347:
2343:
2339:
2335:
2331:
2323:
2321:
2319:
2315:
2311:
2307:
2303:
2299:
2291:
2289:
2282:
2280:
2278:
2276:
2270:
2268:
2264:
2260:
2256:
2252:
2248:
2244:
2239:
2237:
2233:
2229:
2224:
2220:
2212:
2210:
2208:
2205:gene has two
2204:
2199:
2197:
2193:
2189:
2185:
2181:
2177:
2173:
2169:
2165:
2157:
2155:
2153:
2149:
2145:
2141:
2137:
2136:transcriptome
2133:
2129:
2125:
2121:
2117:
2109:
2107:
2105:
2101:
2096:
2094:
2090:
2085:
2083:
2079:
2071:
2069:
2067:
2063:
2059:
2056:
2052:
2048:
2047:
2042:
2034:
2032:
2030:
2026:
2021:
2019:
2015:
2011:
2007:
2003:
1999:
1994:
1992:
1991:knockout mice
1988:
1984:
1981:
1973:
1968:
1963:
1959:
1954:
1950:
1945:
1941:
1939:
1935:
1931:
1927:
1923:
1919:
1915:
1910:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1880:
1876:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1836:
1831:
1827:
1823:
1820:
1816:
1809:
1807:
1804:
1800:
1796:
1792:
1789:
1785:
1781:
1774:
1772:
1768:
1764:
1760:
1756:
1752:
1748:
1744:
1740:
1736:
1732:
1728:
1724:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1662:
1658:
1654:
1650:
1646:
1642:
1638:
1635:
1629:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1597:
1593:
1589:
1585:
1581:
1577:
1573:
1570:
1566:
1559:
1557:
1553:
1549:
1545:
1541:
1535:
1531:
1528:
1522:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1490:
1486:
1482:
1478:
1474:
1470:
1466:
1463:
1461:RefSeq (mRNA)
1459:
1452:
1451:
1446:
1442:
1439:
1433:
1432:
1427:
1423:
1420:
1418:
1414:
1407:
1406:
1401:
1397:
1394:
1388:
1387:
1383:
1379:
1374:
1370:
1367:
1365:
1361:
1354:
1353:
1348:
1344:
1341:
1335:
1334:
1329:
1325:
1322:
1320:
1316:
1313:
1310:
1308:
1305:
1301:
1298:
1294:
1290:
1283:
1279:
1274:
1268:
1265:
1263:
1260:
1258:
1255:
1253:
1250:
1248:
1245:
1243:
1240:
1238:
1235:
1233:
1230:
1228:
1225:
1223:
1220:
1218:
1215:
1213:
1210:
1208:
1205:
1203:
1200:
1198:
1195:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1170:
1168:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1143:
1140:
1138:
1135:
1133:
1130:
1128:
1125:
1123:
1120:
1118:
1115:
1113:
1110:
1108:
1105:
1103:
1100:
1098:
1095:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
994:
992:
989:
988:
982:
979:
977:
976:membrane raft
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
946:mitochondrion
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
911:nuclear speck
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
828:
826:
823:
822:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
720:actin binding
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
673:
672:Gene ontology
669:
665:
653:
648:
644:
637:
630:
625:
622:
620:
616:
608:
603:
592:
588:
585:temporal lobe
584:
580:
576:
572:
568:
564:
560:
556:
555:
552:
548:
543:
540:
531:temporal lobe
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
493:
490:
486:
481:
478:
477:
474:
472:
468:
466:
465:
461:
460:
457:
455:
451:
447:
443:
439:
431:
426:
422:
418:
413:
403:
399:
392:
385:
379:
372:
364:
360:
356:
351:
347:
342:
338:
330:
325:
321:
317:
312:
302:
298:
291:
284:
278:
271:
267:
261:
257:
253:
248:
244:
239:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
187:
182:
175:
170:
165:
154:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
30:
19:
18:Tau (protein)
9507:
9282:Dystroglycan
9237:Beta catenin
9138:
8469:Microtubules
8337:Beta-keratin
8266:
8215:
8161:
8101:
8023:
8009:
7995:
7932:
7769:
7636:Tropomodulin
7228:cytoskeleton
7180:
7151:tau+Proteins
7109:
7105:
7084:
7080:
7045:
7041:
6997:(1): 63–73.
6994:
6990:
6953:
6949:
6922:
6885:
6881:
6848:
6844:
6818:
6814:
6782:(4): 164–9.
6779:
6775:
6742:
6738:
6721:
6717:
6687:(4): 261–4.
6684:
6680:
6647:
6643:
6618:
6614:
6581:
6577:
6560:
6556:
6529:
6525:
6484:
6480:
6443:
6439:
6409:(5): 193–9.
6406:
6402:
6365:
6361:
6351:
6324:
6320:
6310:
6275:
6271:
6261:
6226:
6222:
6212:
6179:
6175:
6169:
6142:
6138:
6128:
6101:
6097:
6087:
6060:
6056:
6046:
5983:
5977:
5966:
5927:
5923:
5913:
5878:
5874:
5864:
5829:
5825:
5815:
5782:
5779:Neurosurgery
5778:
5772:
5763:
5754:
5719:
5715:
5705:
5668:
5664:
5654:
5643:. Retrieved
5631:
5621:
5611:, retrieved
5607:
5598:
5561:
5557:
5547:
5514:
5510:
5504:
5459:
5455:
5445:
5408:
5404:
5394:
5357:
5353:
5343:
5310:
5306:
5300:
5267:
5263:
5257:
5227:(1): 26–35.
5224:
5220:
5214:
5180:(1): 55–61.
5177:
5173:
5163:
5128:
5124:
5114:
5079:
5075:
5065:
5008:
5004:
4994:
4962:(4): 164–9.
4959:
4955:
4949:
4914:
4910:
4900:
4865:
4861:
4851:
4816:
4812:
4802:
4765:
4761:
4751:
4724:
4720:
4710:
4673:
4669:
4659:
4632:
4628:
4618:
4591:
4588:Cell Reports
4587:
4574:
4537:
4533:
4523:
4478:
4474:
4464:
4419:
4415:
4405:
4372:
4368:
4361:
4334:
4330:
4320:
4287:
4283:
4277:
4250:
4246:
4236:
4201:
4197:
4187:
4162:
4158:
4152:
4128:(5): 416–9.
4125:
4121:
4111:
4076:
4072:
4062:
4029:
4025:
4018:
3991:
3987:
3977:
3952:
3948:
3941:
3904:
3900:
3890:
3865:
3861:
3851:
3816:
3813:Neuroscience
3812:
3802:
3761:
3757:
3751:
3718:
3714:
3672:
3668:
3658:
3633:
3629:
3619:
3584:
3580:
3570:
3525:
3521:
3511:
3476:
3472:
3416:
3412:
3402:
3365:
3361:
3351:
3316:
3312:
3302:
3265:
3261:
3251:
3218:
3214:
3164:
3160:
3116:
3112:
3066:
3062:
3056:
3031:
3027:
2991:
2987:
2981:
2964:
2960:
2954:
2917:
2913:
2903:
2870:
2866:
2859:
2814:
2810:
2800:
2755:
2751:
2729:
2720:
2711:
2702:
2550:
2547:Interactions
2522:
2498:
2486:
2479:
2475:beta-amyloid
2463:
2435:
2420:
2407:
2379:pathogenesis
2361:
2327:
2305:
2295:
2286:
2274:
2271:
2255:phosphatases
2245:, including
2240:
2216:
2202:
2200:
2163:
2161:
2142:or in brain
2113:
2097:
2092:
2086:
2075:
2058:
2044:
2038:
2022:
2004:portions of
1995:
1983:
1980:microtubules
1977:
1911:
1883:microtubules
1874:
1866:produced by
1859:
1855:
1851:
1848:tau proteins
1847:
1845:
1771:NP_001390945
1767:NP_001390944
1763:NP_001390943
1759:NP_001390941
1755:NP_001390940
1751:NP_001390939
1747:NP_001390935
1743:NP_001390934
1739:NP_001390933
1735:NP_001390931
1731:NP_001390928
1727:NP_001390927
1723:NP_001390925
1719:NP_001390923
1715:NP_001390921
1711:NP_001390919
1707:NP_001390916
1703:NP_001390913
1699:NP_001390912
1695:NP_001390911
1691:NP_001390910
1687:NP_001390909
1683:NP_001390908
1679:NP_001390907
1675:NP_001390906
1671:NP_001390905
1667:NP_001390904
1664:
1653:NP_001272385
1649:NP_001272384
1645:NP_001272383
1641:NP_001033698
1626:NP_001364197
1622:NP_001364196
1618:NP_001364195
1614:NP_001364194
1599:
1588:NP_001190181
1584:NP_001190180
1580:NP_001116539
1576:NP_001116538
1556:NM_001285456
1552:NM_001285455
1548:NM_001285454
1540:NM_001038609
1537:
1519:NM_001377268
1515:NM_001377267
1511:NM_001377266
1507:NM_001377265
1492:
1481:NM_001203252
1477:NM_001203251
1473:NM_001123067
1469:NM_001123066
1448:
1429:
1403:
1376:
1350:
1331:
1311:
1306:
881:cytoskeleton
523:hypothalamus
469:
462:
428:104,332,090
415:104,231,390
189:External IDs
80:
29:
9428:Plakophilin
9379:Desmoplakin
9139:Tau protein
7913:Cytokeratin
7709:Tropomyosin
7257:Myofilament
7048:(1): 1–10.
5984:Tau Biology
5313:(1): 22–6.
3669:NeuroReport
2631:Proteopathy
2525:tauopathies
2489:immunoassay
2469:as well as
2455:cytoplasmic
2391:tauopathies
2314:hippocampal
2207:haplogroups
2140:myelination
2082:habituation
2041:translation
896:microtubule
851:growth cone
765:RNA binding
715:DNA binding
327:46,028,334
314:45,894,527
167:Identifiers
9524:Categories
9508:See also:
9480:Crescentin
9399:Periplakin
9389:Envoplakin
9277:Dystrophin
8894:axonemal:
8388:Internexin
8367:Peripherin
6797:10316/4769
5645:2020-07-29
5613:2020-01-27
5564:(1): 462.
5360:(3): 260.
4977:10316/4769
3528:(1): 110.
3368:(1): 204.
2697:, May 2017
2676:, May 2017
2653:References
2445:, such as
2443:polyanions
2413:proteins.
2389:and other
2367:inclusions
2234:(Ser) and
2192:C-terminal
2152:depression
2132:chromosome
2093:Drosophila
2046:Drosophila
1903:astrocytes
1858:ssociated
473:(ortholog)
210:HomoloGene
9097:Centrin 3
9092:Centrin 2
9087:Centrin 1
8425:Syncoilin
8330:Not alpha
7896:filaments
7848:Fibrillin
6504:1765/9318
6036:ignored (
6026:cite book
6018:211475911
5807:196391183
5640:0362-4331
4676:(1): 31.
3907:(1): 91.
3544:2051-5960
3433:0261-4189
2920:(1): 52.
2597:Tauopathy
2451:ubiquitin
2399:misfolded
2358:Tauopathy
2318:microglia
2283:Mechanism
2236:threonine
2213:Structure
2128:apoptosis
2051:ribosomes
1998:dendrites
1914:dementias
1870:from the
1657:NP_034968
1610:NP_058525
1606:NP_058519
1602:NP_058518
1592:NP_005901
1544:NM_010838
1503:NM_016841
1499:NM_016835
1495:NM_016834
1485:NM_005910
1297:Orthologs
971:main axon
836:cell body
831:cytoplasm
577:CA3 field
218:GeneCards
9535:Proteins
9463:Nonhuman
9423:Vinculin
9384:Dystonin
9316:Spectrin
9289:Utrophin
9269:Membrane
9224:Catenins
9156:Stathmin
9144:Dynactin
9024:DYNC2LI1
9019:DYNC1LI2
9014:DYNC1LI1
8679:Kinesins
8483:Tubulins
8372:Vimentin
7904:Type 1/2
7806:Profilin
7801:Gelsolin
7663:Troponin
7224:Proteins
7093:16416389
7072:17555970
7029:40879765
7021:17493040
6978:36430988
6970:17373874
6941:16987883
6910:19357113
6902:16958643
6865:16793187
6835:16042549
6806:15823754
6767:28578030
6759:15365985
6730:15266787
6709:36197015
6701:15178932
6672:27693523
6664:15178931
6635:12470988
6606:24891421
6598:11831556
6569:11831025
6548:10899436
6513:10767321
6468:22471158
6431:44928661
6384:10840038
6302:11264299
6253:11826099
6196:14528052
6161:10464279
6120:31257249
6079:24493463
6010:32096046
5954:22116192
5905:23208308
5856:22593173
5799:15987548
5746:32722745
5697:32725127
5590:35008886
5539:23900723
5437:25339173
5386:30893872
5335:37380445
5327:11801334
5292:38730940
5284:10959034
5241:11837744
5206:19742193
5155:22561167
5106:27878758
5045:11381127
4986:15823754
4941:18930955
4892:18896805
4884:15006350
4843:26436904
4794:29238289
4743:28772101
4702:30823892
4651:30580037
4610:25981034
4566:19282288
4456:15249677
4397:40592137
4312:94265621
4269:11104762
4179:16042549
4144:18648385
4122:Heredity
4103:19165922
4054:38047848
4046:16906163
4010:15615637
3933:29187252
3882:20555133
3843:20434528
3794:32771613
3786:17478722
3743:31204860
3735:10688046
3697:25235996
3689:17558294
3650:11228161
3611:30759285
3562:34147135
3503:26791227
3451:31268600
3394:15642108
3343:18776289
3335:20655099
3294:22720190
3243:32708424
3235:18448228
3143:31488613
3008:20678581
2946:35765081
2895:19627629
2693:–
2672:–
2590:See also
2553:interact
2439:protease
2403:synapses
2324:Toxicity
2184:isoforms
2158:Genetics
2072:Behavior
2014:isoforms
1969:Function
1920:such as
1819:Wikidata
1276:Sources:
956:axolemma
906:membrane
871:dendrite
306:17q21.31
9450:PLEKHA7
9404:Plectin
9369:Plakins
9294:Ankyrin
9193:Dynamin
9123:Spastin
9118:Katanin
9082:CAMSAP3
9077:CAMSAP2
9072:CAMSAP1
9044:DYNLRB2
9039:DYNLRB1
9009:DYNC1I2
9004:DYNC1I1
8999:DYNC2H1
8994:DYNC1H1
8887:Dyneins
8611:TUBGCP6
8606:TUBGCP5
8601:TUBGCP4
8596:TUBGCP3
8591:TUBGCP2
8420:Synemin
8163:type II
8025:type II
7908:Keratin
7853:Filamin
7794:Destrin
7777:Cofilin
7738:Actinin
7309:Myosins
7226:of the
7187:PDBe-KB
7177:UniProt
7136:3139677
7127:2115262
7063:2801069
7012:8095608
6873:6848053
6460:7566346
6423:1713721
6343:2833519
6293:6762409
6244:6758498
6204:9086733
5945:3326246
5896:3624697
5847:3739428
5737:7388060
5688:7596823
5581:8745479
5531:2126970
5496:8393578
5464:Bibcode
5428:4256367
5377:6468864
5249:6799990
5197:2738403
5146:3399531
5097:5684262
5013:Bibcode
4932:2644648
4834:4694577
4785:5712583
4768:: 667.
4693:6397507
4557:2676015
4515:8990203
4483:Bibcode
4424:Bibcode
4389:7946342
4353:7983034
4304:1560225
4228:9169588
4219:1218358
4094:2684794
3969:3103857
3924:5707803
3834:2900546
3766:Bibcode
3758:Science
3602:6426815
3553:8214309
3494:4719006
3442:6600635
3285:3375147
3197:4322543
3189:8202139
3169:Bibcode
3134:6794924
2973:1903170
2937:9241296
2887:2484340
2851:3131773
2819:Bibcode
2792:1057175
2760:Bibcode
2695:Ensembl
2674:Ensembl
2535:. True
2527:, like
2375:tangles
2312:to the
2292:Release
2277:-GlcNAc
2243:kinases
2219:domains
2176:encoded
2154:, etc.
2150:and in
2144:insulin
2010:tubulin
1916:of the
1893:of the
1891:neurons
1854:ubulin
1417:UniProt
1364:Ensembl
1303:Species
1282:QuickGO
891:cytosol
886:nucleus
448:pattern
174:Aliases
9351:SPTBN5
9346:SPTBN4
9341:SPTBN2
9336:SPTBN1
9326:SPTAN1
9161:Tektin
9054:DYNLT3
9049:DYNLT1
9034:DYNLL2
9029:DYNLL1
8976:DNALI1
8961:DNAH17
8956:DNAH14
8951:DNAH13
8946:DNAH12
8941:DNAH11
8936:DNAH10
8857:KIF26B
8852:KIF26A
8827:KIF21B
8822:KIF21A
8817:KIF20B
8812:KIF20A
8802:KIF18B
8797:KIF18A
8787:KIF16B
8772:KIF13B
8767:KIF13A
8566:TUBB4Q
8551:TUBB2C
8546:TUBB2B
8541:TUBB2A
8521:TUBA4A
8516:TUBA3E
8511:TUBA3D
8506:TUBA3C
8501:TUBA1C
8496:TUBA1B
8491:TUBA1A
8434:Type 5
8393:Nestin
8381:Type 4
8357:Desmin
8350:Type 3
8103:type I
7934:type I
7880:TRIOBP
7546:MYO18B
7541:MYO18A
7537:XVIII
7531:MYO15A
7266:Actins
7182:P10636
7157:(MeSH)
7134:
7124:
7091:
7070:
7060:
7027:
7019:
7009:
6976:
6968:
6939:
6908:
6900:
6871:
6863:
6833:
6804:
6765:
6757:
6728:
6707:
6699:
6670:
6662:
6633:
6604:
6596:
6567:
6546:
6511:
6466:
6458:
6429:
6421:
6382:
6341:
6300:
6290:
6251:
6241:
6202:
6194:
6159:
6118:
6077:
6016:
6008:
5998:
5952:
5942:
5903:
5893:
5854:
5844:
5805:
5797:
5744:
5734:
5695:
5685:
5671:(11).
5638:
5588:
5578:
5537:
5529:
5494:
5484:
5435:
5425:
5384:
5374:
5333:
5325:
5290:
5282:
5247:
5239:
5204:
5194:
5153:
5143:
5104:
5094:
5043:
5033:
4984:
4939:
4929:
4890:
4882:
4841:
4831:
4792:
4782:
4741:
4700:
4690:
4649:
4608:
4564:
4554:
4513:
4503:
4454:
4447:490015
4444:
4395:
4387:
4369:Neuron
4351:
4310:
4302:
4267:
4226:
4216:
4177:
4142:
4101:
4091:
4052:
4044:
4008:
3967:
3931:
3921:
3880:
3841:
3831:
3792:
3784:
3741:
3733:
3695:
3687:
3648:
3609:
3599:
3560:
3550:
3542:
3501:
3491:
3449:
3439:
3431:
3392:
3385:549057
3382:
3341:
3333:
3292:
3282:
3241:
3233:
3195:
3187:
3161:Nature
3141:
3131:
3083:146092
3081:
3048:599557
3046:
3006:
2971:
2944:
2934:
2893:
2885:
2867:Neuron
2849:
2842:280359
2839:
2790:
2783:432646
2780:
2555:with:
2537:prions
2467:kinase
2232:serine
2106:time.
2002:distal
1805:search
1803:PubMed
1450:P10637
1431:P10636
1319:Entrez
1042:memory
619:BioGPS
198:157140
9411:Talin
9394:MACF1
9362:Other
9321:SPTA1
9186:TEKT5
9181:TEKT4
9176:TEKT3
9171:TEKT2
9166:TEKT1
9149:DCTN1
9132:Other
8986:DNAL4
8981:DNAL1
8971:DNAI2
8966:DNAI1
8931:DNAH9
8926:DNAH8
8921:DNAH7
8916:DNAH6
8911:DNAH5
8906:DNAH3
8901:DNAH2
8896:DNAH1
8877:KIFC3
8872:KIFC2
8867:KIFC1
8862:KIF27
8847:KIF25
8842:KIF24
8837:KIF23
8832:KIF22
8807:KIF19
8792:KIF17
8782:KIF15
8777:KIF14
8762:KIF12
8757:KIF11
8737:KIF5C
8732:KIF5B
8727:KIF5A
8722:KIF4B
8717:KIF4A
8712:KIF3C
8707:KIF3B
8702:KIF2C
8697:KIF2A
8692:KIF1B
8687:KIF1A
8659:MAP1B
8654:MAP1A
8621:TUBE1
8616:TUBD1
8586:TUBG2
8581:TUBG1
8576:TUBB8
8571:TUBB6
8561:TUBB4
8556:TUBB3
8536:TUBB1
8526:TUBA8
7875:Espin
7836:Other
7823:Titin
7629:Other
7618:MYLL1
7613:MYLK2
7603:MYLIP
7588:MYL6B
7521:MYO10
7511:MYO9B
7506:MYO9A
7496:MYO7B
7491:MYO7A
7471:MYO5C
7466:MYO5B
7461:MYO5A
7451:MYO3B
7446:MYO3A
7436:MYH16
7431:MYH15
7426:MYH14
7421:MYH13
7416:MYH11
7411:MYH10
7396:MYH7B
7355:MYO1H
7350:MYO1G
7345:MYO1F
7340:MYO1E
7335:MYO1D
7330:MYO1C
7325:MYO1B
7320:MYO1A
7235:Human
7025:S2CID
6974:S2CID
6906:S2CID
6869:S2CID
6763:S2CID
6705:S2CID
6668:S2CID
6602:S2CID
6464:S2CID
6427:S2CID
6200:S2CID
6014:S2CID
5924:Brain
5875:Brain
5803:S2CID
5604:"A68"
5535:S2CID
5487:47025
5354:Cells
5331:S2CID
5288:S2CID
5245:S2CID
5125:Prion
5036:34454
4888:S2CID
4584:(PDF)
4506:19321
4393:S2CID
4308:S2CID
4050:S2CID
3790:S2CID
3739:S2CID
3693:S2CID
3339:S2CID
3239:S2CID
3193:S2CID
2891:S2CID
2646:Prion
2583:YWHAZ
2579:, and
2577:S100B
2411:prion
2334:GSK-3
2330:PAR-1
2172:exons
2006:axons
1887:axons
1352:17762
1312:Mouse
1307:Human
1278:Amigo
471:Mouse
464:Human
411:Start
346:Mouse
310:Start
243:Human
214:74962
206:97180
9495:ParM
9490:MreB
9485:FtsZ
9445:ACF7
9438:PKP2
9433:PKP1
9416:TLN1
9331:SPTB
9309:ANK3
9304:ANK2
9299:ANK1
9208:DNM3
9203:DNM2
9198:DNM1
9102:PCM1
8752:KIF9
8747:KIF7
8742:KIF6
8669:MAP4
8664:MAP2
8631:MAPs
8531:TUBB
8474:MAPs
8472:and
8413:NEFH
8408:NEFM
8403:NEFL
8362:GFAP
8010:none
7868:FLNC
7863:FLNB
7858:FLNA
7608:MYLK
7598:MYL9
7593:MYL7
7583:MYL6
7578:MYL5
7573:MYL4
7568:MYL3
7563:MYL2
7558:MYL1
7487:VII
7481:MYO6
7442:III
7406:MYH9
7401:MYH8
7391:MYH7
7386:MYH6
7381:MYH4
7376:MYH3
7371:MYH2
7366:MYH1
7248:ABPs
7246:and
7175:for
7132:PMID
7089:PMID
7068:PMID
7017:PMID
6966:PMID
6937:PMID
6898:PMID
6861:PMID
6831:PMID
6802:PMID
6755:PMID
6726:PMID
6697:PMID
6660:PMID
6631:PMID
6594:PMID
6565:PMID
6544:PMID
6530:1502
6509:PMID
6456:PMID
6419:PMID
6380:PMID
6339:PMID
6298:PMID
6249:PMID
6192:PMID
6157:PMID
6116:PMID
6075:PMID
6038:help
6006:PMID
5996:ISBN
5950:PMID
5901:PMID
5852:PMID
5795:PMID
5764:NOVA
5742:PMID
5716:JAMA
5693:PMID
5636:ISSN
5586:PMID
5527:PMID
5492:PMID
5433:PMID
5382:PMID
5323:PMID
5280:PMID
5237:PMID
5202:PMID
5151:PMID
5102:PMID
5041:PMID
4982:PMID
4937:PMID
4880:PMID
4862:Cell
4839:PMID
4790:PMID
4739:PMID
4698:PMID
4647:PMID
4606:PMID
4562:PMID
4511:PMID
4452:PMID
4385:PMID
4349:PMID
4300:PMID
4265:PMID
4224:PMID
4175:PMID
4140:PMID
4099:PMID
4042:PMID
4006:PMID
3992:1739
3965:PMID
3929:PMID
3878:PMID
3839:PMID
3782:PMID
3731:PMID
3685:PMID
3646:PMID
3607:PMID
3558:PMID
3540:ISSN
3499:PMID
3447:PMID
3429:ISSN
3390:PMID
3331:PMID
3313:Cell
3290:PMID
3266:2012
3231:PMID
3185:PMID
3139:PMID
3079:PMID
3044:PMID
3004:PMID
2969:PMID
2942:PMID
2883:PMID
2847:PMID
2788:PMID
2541:PRNP
2531:and
2421:The
2338:CDK5
2336:and
2306:MAPT
2263:PP2B
2261:and
2259:PP2A
2249:, a
2203:MAPT
2201:The
2164:MAPT
2126:and
2066:rpS6
2016:and
1958:DAPI
1949:MAP2
1924:and
1905:and
1875:MAPT
1872:gene
1846:The
1333:4137
916:axon
454:Bgee
402:Band
363:Chr.
301:Band
260:Chr.
222:MAPT
194:OMIM
181:MAPT
151:5E2V
147:5E2W
143:5HF3
139:4Y3B
135:5DMG
131:4Y32
127:4Y5I
123:4TQE
119:2MZ7
115:4NP8
111:4FL5
107:4E0O
103:4E0N
99:4E0M
95:3OVL
91:2ON9
87:4GLR
83:1I8H
64:RCSB
61:PDBe
35:MAPT
9259:GAN
9242:APC
8649:EB3
8644:EB2
8639:EB1
8445:A/C
8128:33B
8123:33A
7527:XV
7502:IX
7477:VI
7362:II
7173:PDB
7122:PMC
7114:doi
7110:107
7058:PMC
7050:doi
7007:PMC
6999:doi
6958:doi
6927:doi
6890:doi
6853:doi
6823:doi
6792:hdl
6784:doi
6747:doi
6689:doi
6652:doi
6623:doi
6586:doi
6534:doi
6499:hdl
6489:doi
6448:doi
6411:doi
6370:doi
6366:275
6329:doi
6325:263
6288:PMC
6280:doi
6239:PMC
6231:doi
6184:doi
6147:doi
6143:274
6106:doi
6102:139
6065:doi
5988:doi
5940:PMC
5932:doi
5928:135
5891:PMC
5883:doi
5879:136
5842:PMC
5834:doi
5787:doi
5732:PMC
5724:doi
5720:324
5683:PMC
5673:doi
5669:217
5576:PMC
5566:doi
5519:doi
5515:531
5482:PMC
5472:doi
5423:PMC
5413:doi
5409:289
5372:PMC
5362:doi
5315:doi
5272:doi
5229:doi
5225:103
5192:PMC
5182:doi
5141:PMC
5133:doi
5092:PMC
5084:doi
5031:PMC
5021:doi
4972:hdl
4964:doi
4927:PMC
4919:doi
4870:doi
4866:116
4829:PMC
4821:doi
4780:PMC
4770:doi
4729:doi
4688:PMC
4678:doi
4637:doi
4633:431
4596:doi
4552:PMC
4542:doi
4538:284
4501:PMC
4491:doi
4442:PMC
4432:doi
4420:101
4377:doi
4339:doi
4335:269
4292:doi
4255:doi
4251:276
4214:PMC
4206:doi
4202:323
4167:doi
4130:doi
4126:101
4089:PMC
4081:doi
4034:doi
3996:doi
3957:doi
3953:387
3919:PMC
3909:doi
3870:doi
3829:PMC
3821:doi
3817:169
3774:doi
3762:316
3723:doi
3719:279
3677:doi
3638:doi
3634:114
3597:PMC
3589:doi
3585:137
3548:PMC
3530:doi
3489:PMC
3481:doi
3437:PMC
3421:doi
3380:PMC
3370:doi
3321:doi
3317:142
3280:PMC
3270:doi
3223:doi
3177:doi
3165:369
3129:PMC
3121:doi
3071:doi
3067:116
3036:doi
3032:116
2996:doi
2932:PMC
2922:doi
2875:doi
2837:PMC
2827:doi
2778:PMC
2768:doi
2566:FYN
2381:of
2373:of
2247:PKN
2196:CNS
2043:in
1885:in
424:End
323:End
226:OMA
202:MGI
54:PDB
9526::
8455:B2
8450:B1
8443::
8319:80
8314:79
8309:78
8304:77
8299:76
8294:75
8289:74
8284:73
8279:72
8274:71
8258:40
8253:39
8248:28
8243:27
8238:26
8233:25
8228:24
8223:23
8198:86
8193:85
8188:84
8183:83
8178:82
8173:81
8153:38
8148:37
8143:36
8138:35
8133:34
8118:32
8113:31
8070:6C
8065:6B
8060:6A
8040:2A
8015:21
8003:18
7989:20
7984:19
7979:17
7974:16
7969:15
7964:14
7959:13
7954:12
7949:10
7553:LC
7517:X
7457:V
7316:I
7299:G2
7294:G1
7289:C1
7279:A2
7274:A1
7179::
7130:.
7120:.
7108:.
7104:.
7085:43
7083:.
7066:.
7056:.
7046:27
7044:.
7040:.
7023:.
7015:.
7005:.
6995:17
6993:.
6989:.
6972:.
6964:.
6954:11
6952:.
6935:.
6921:.
6904:.
6896:.
6886:36
6884:.
6867:.
6859:.
6849:30
6847:.
6829:.
6819:33
6817:.
6800:.
6790:.
6780:11
6778:.
6761:.
6753:.
6743:24
6741:.
6722:42
6720:.
6703:.
6695:.
6685:17
6683:.
6666:.
6658:.
6648:17
6646:.
6629:.
6617:.
6600:.
6592:.
6582:24
6580:.
6561:73
6559:.
6542:.
6528:.
6524:.
6507:.
6497:.
6483:.
6479:.
6462:.
6454:.
6444:16
6442:.
6425:.
6417:.
6407:14
6405:.
6378:.
6364:.
6360:.
6337:.
6323:.
6319:.
6296:.
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