527:
InChI=1S/C164H252N44O55S/c1-21-77(11)126(156(255)187-95(44-46-114(167)214)141(240)206-130(83(17)211)160(259)186-93(42-33-34-49-165)140(239)202-129(80(14)24-4)159(258)208-131(84(18)212)161(260)200-111(163(262)263)66-125(230)231)203-151(250)100(54-76(9)10)189-145(244)103(57-88-67-175-92-41-32-31-40-90(88)92)192-147(246)105(60-116(169)216)199-157(256)127(78(12)22-2)204-152(251)102(56-87-38-29-26-30-39-87)190-149(248)109(64-123(226)227)195-137(236)94(43-35-50-174-164(171)172)183-134(233)82(16)179-133(232)81(15)180-142(241)98(52-74(5)6)188-146(245)104(59-115(168)215)194-150(249)110(65-124(228)229)196-143(242)99(53-75(7)8)198-158(257)128(79(13)23-3)205-162(261)132(85(19)213)207-153(252)106(61-117(170)217)193-139(238)97(48-51-264-20)185-138(237)96(45-47-120(220)221)184-148(247)108(63-122(224)225)197-155(254)113(72-210)201-144(243)101(55-86-36-27-25-28-37-86)191-154(253)112(71-209)182-119(219)70-177-136(235)107(62-121(222)223)181-118(218)69-176-135(234)91(166)58-89-68-173-73-178-89/h25-32,36-41,67-68,73-85,91,93-113,126-132,175,209-213H,21-24,33-35,42-66,69-72,165-166H2,1-20H3,(H2,167,214)(H2,168,215)(H2,169,216)(H2,170,217)(H,173,178)(H,176,234)(H,177,235)(H,179,232)(H,180,241)(H,181,218)(H,182,219)(H,183,233)(H,184,247)(H,185,237)(H,186,259)(H,187,255)(H,188,245)(H,189,244)(H,190,248)(H,191,253)(H,192,246)(H,193,238)(H,194,249)(H,195,236)(H,196,242)(H,197,254)(H,198,257)(H,199,256)(H,200,260)(H,201,243)(H,202,239)(H,203,250)(H,204,251)(H,205,261)(H,206,240)(H,207,252)(H,208,258)(H,220,221)(H,222,223)(H,224,225)(H,226,227)(H,228,229)(H,230,231)(H,262,263)(H4,171,172,174)/t77-,78-,79-,80-,81-,82-,83+,84+,85+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,126-,127-,128-,129-,130-,131-,132-/m0/s1
485:
507:
CC(C)(NC(=O)(CC(C)C)NC(=O)(Cc1cc2ccccc12)NC(=O)(CC(N)=O)NC(=O)(NC(=O)(Cc1ccccc1)NC(=O)(CC(O)=O)NC(=O)(CCCNC(N)=N)NC(=O)(C)NC(=O)(C)NC(=O)(CC(C)C)NC(=O)(CC(N)=O)NC(=O)(CC(O)=O)NC(=O)(CC(C)C)NC(=O)(NC(=O)(NC(=O)(CC(N)=O)NC(=O)(CCSC)NC(=O)(CCC(O)=O)NC(=O)(CC(O)=O)NC(=O)(CO)NC(=O)(Cc1ccccc1)NC(=O)(CO)NC(=O)CNC(=O)(CC(O)=O)NC(=O)CNC(=O)(N)Cc1cnc1)(C)O)(C)CC)(C)CC)C(=O)N(CCC(N)=O)C(=O)N((C)O)C(=O)N(CCCCN)C(=O)N((C)CC)C(=O)N((C)O)C(=O)N(CC(O)=O)C(O)=O
262:
L-histidylglycyl-L-α-aspartylglycyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-α-glutamyl-L-methionyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-asparaginyl-L-leucyl-L-alanyl-L-alanyl-L-arginyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-threonyl-L-lysyl-L-isoleucyl-L-threonyl-L-aspartic acid
31:
1398:
954:
1418:
642:
and increases its half-life from seven minutes (GLP-2) to about two hours, while retaining its biological actions. These include maintenance of the intestinal mucosa, increasing intestinal blood flow, reducing
601:
substitution of water, minerals and vitamins (depending on which part of the gut has been removed) is often necessary. Teduglutide may reduce or shorten the necessity of such infusions by improving the
947:
160:
1433:
940:
115:
741:
689:
53:
499:
715:
1334:
664:
It was approved in both the
European Union (brand name Revestive) and the United States (brand name Gattex) in 2012. It was granted
519:
774:
254:
145:
71:
1388:
356:
90:
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325:
869:"Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome"
1295:
1239:
1229:
1056:
570:
101:
108:
841:
618:(28%), nausea (27%) and vomiting (14%), local reactions at the injection site (21%), and headache (17%).
1423:
1340:
1182:
990:
615:
316:
932:
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1254:
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639:
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405:
345:
184:
172:
43:
1234:
1205:
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888:
880:
614:
Common adverse effects in clinical studies included abdominal discomfort (49% of patients),
582:
421:
280:
203:
775:"Gattex- teduglutide injection, powder, lyophilized, for solution; Gattex- teduglutide kit"
365:
1402:
1330:
1244:
1210:
1170:
1140:
1135:
594:
221:
211:
585:
and secretion. It was approved in both the
European Union and the United States in 2012.
1370:
1259:
1249:
1000:
921:
Klement A (5 January 2015). "Das
Kurzdarmsyndrom ist erstmals behandelbar: Revestive".
893:
868:
1412:
1300:
1222:
1010:
746:
305:
1375:
1360:
1355:
1113:
1098:
1015:
972:
128:
123:
63:
690:"Prescription medicines: registration of new chemical entities in Australia, 2017"
1187:
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665:
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1305:
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1218:
1005:
57:
22:
902:
85:
30:
1061:
995:
635:
631:
566:
291:
1030:
578:
385:
1200:
484:
475:
396:
716:"Prescription medicines and biologicals: TGA annual summary 2017"
376:
190:
936:
178:
80:
154:
1419:
Drugs acting on the gastrointestinal system and metabolism
742:"Health Canada New Drug Authorizations: 2015 Highlights"
167:
544:
1386:
593:
Up to a certain point, the gut can adapt to partial
1273:
1029:
980:
626:Teduglutide differs from natural GLP-2 by a single
473:
456:
420:
415:
395:
375:
355:
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114:
100:
70:
52:
42:
37:
769:
767:
765:
836:
834:
832:
573:(GLP-2) analog that is used for the treatment of
1434:Drugs developed by Takeda Pharmaceutical Company
802:
800:
798:
796:
304:
638:. This blocks breaking down of the molecule by
279:
948:
8:
597:that result in short bowel syndrome. Still,
89:
21:
955:
941:
933:
344:
29:
916:
914:
912:
892:
364:
873:Therapeutic Advances in Gastroenterology
1393:
681:
524:
504:
259:
720:Therapeutic Goods Administration (TGA)
694:Therapeutic Goods Administration (TGA)
20:
404:
62:
7:
846:Union Register of medicinal products
127:
384:
295:
606:and possibly by other mechanisms.
14:
622:Chemistry and mechanism of action
1396:
923:Österreichische Apothekerzeitung
438:
432:
842:"Revestive Product information"
532:Key:CILIXQOJUNDIDU-ASQIGDHWSA-N
581:growth and possibly restoring
450:
444:
426:
1:
557:, sold under the brand names
1044:phenylalanine ammonia-lyase
565:(US), is a 33-membered poly
1450:
925:(in German) (1/2015): 20f.
416:Chemical and physical data
813:European Medicines Agency
670:European Medicines Agency
645:gastrointestinal motility
540:
515:
495:
250:
28:
885:10.1177/1756283X11436318
867:Jeppesen PB (May 2012).
577:. It works by promoting
1296:Glycerol phenylbutyrate
1240:eladocagene exuparvovec
1230:atidarsagene autotemcel
1057:Carbohydrate metabolism
571:glucagon-like peptide-2
616:respiratory infections
109:Subcutaneous injection
1341:Sodium phenylbutyrate
1335:+sodium phenylacetate
1183:iduronate-2-sulfatase
1146:Pegunigalsidase alfa
1087:Cipaglucosidase alfa
1083:Avalglucosidase alfa
640:dipeptidyl peptidase
575:short bowel syndrome
1131:alpha-galactosidase
668:designation by the
655:Society and culture
634:is replaced with a
163:(Prescription only)
25:
1366:Uridine triacetate
1281:Anethole trithione
1124:Velaglucerase alfa
1119:Taliglucerase alfa
1104:glucocerebrosidase
1079:Alglucosidase alfa
848:. 4 September 2012
817:. 11 December 2001
781:. 28 February 2024
1384:
1383:
1265:vestronidase alfa
1154:Glycosaminoglycan
1074:alpha-glucosidase
651:of gastric acid.
604:intestinal mucosa
552:
551:
486:Interactive image
194:
182:
170:
158:
83:
48:Revestive, Gattex
16:Chemical compound
1441:
1401:
1400:
1399:
1392:
1235:cerliponase alfa
1206:lysosomal lipase
1194:idursulfase beta
965:alimentary tract
957:
950:
943:
934:
927:
926:
918:
907:
906:
896:
864:
858:
857:
855:
853:
838:
827:
826:
824:
822:
808:"Revestive EPAR"
804:
791:
790:
788:
786:
771:
760:
759:
757:
755:
738:
732:
731:
729:
727:
712:
706:
705:
703:
701:
686:
583:gastric emptying
548:
547:
488:
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66:
33:
26:
24:
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1440:
1439:
1438:
1409:
1408:
1407:
1397:
1395:
1387:
1385:
1380:
1331:Sodium benzoate
1269:
1255:pabinafusp alfa
1245:elosulfase alfa
1211:Sebelipase alfa
1171:arylsulfatase B
1141:Agalsidase beta
1136:Agalsidase alfa
1025:
984:and derivatives
976:
961:
931:
930:
920:
919:
910:
866:
865:
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723:
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662:
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624:
612:
610:Adverse effects
591:
543:
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491:
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257:
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212:Bioavailability
204:Pharmacokinetic
198:
135:
103:
96:
17:
12:
11:
5:
1447:
1445:
1437:
1436:
1431:
1426:
1421:
1411:
1410:
1406:
1405:
1382:
1381:
1379:
1378:
1373:
1371:Velmanase alfa
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1277:
1275:
1271:
1270:
1268:
1267:
1262:
1260:pegzilarginase
1257:
1252:
1250:olipudase alfa
1247:
1242:
1237:
1232:
1226:
1225:
1215:
1214:
1197:
1196:
1191:
1179:
1167:
1150:
1149:
1143:
1138:
1127:
1121:
1116:
1111:
1091:
1090:
1070:
1053:
1052:
1035:
1033:
1027:
1026:
1024:
1023:
1018:
1013:
1008:
1003:
1001:Carglumic acid
998:
993:
987:
985:
978:
977:
962:
960:
959:
952:
945:
937:
929:
928:
908:
859:
828:
792:
761:
733:
722:. 21 June 2022
707:
696:. 21 June 2022
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106:
104:administration
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76:
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68:
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60:
50:
49:
46:
40:
39:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
1446:
1435:
1432:
1430:
1427:
1425:
1422:
1420:
1417:
1416:
1414:
1404:
1394:
1390:
1377:
1374:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1336:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1301:Leriglitazone
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1278:
1276:
1272:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1227:
1224:
1223:Asfotase alfa
1220:
1217:
1216:
1212:
1208:
1207:
1202:
1199:
1198:
1195:
1192:
1189:
1185:
1184:
1180:
1177:
1173:
1172:
1168:
1165:
1161:
1160:
1155:
1152:
1151:
1147:
1144:
1142:
1139:
1137:
1133:
1132:
1128:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1106:
1105:
1100:
1096:
1093:
1092:
1088:
1084:
1080:
1076:
1075:
1071:
1068:
1064:
1063:
1058:
1055:
1054:
1050:
1046:
1045:
1040:
1037:
1036:
1034:
1032:
1028:
1022:
1019:
1017:
1014:
1012:
1011:Levocarnitine
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
988:
986:
983:
979:
974:
970:
966:
958:
953:
951:
946:
944:
939:
938:
935:
924:
917:
915:
913:
909:
904:
900:
895:
890:
886:
882:
879:(3): 159–71.
878:
874:
870:
863:
860:
847:
843:
837:
835:
833:
829:
816:
814:
809:
803:
801:
799:
797:
793:
780:
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768:
766:
762:
749:
748:
747:Health Canada
743:
737:
734:
721:
717:
711:
708:
695:
691:
685:
682:
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195: Rx-only
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47:
45:
41:
38:Clinical data
36:
32:
27:
19:
1424:Orphan drugs
1376:Zinc acetate
1361:Triheptanoin
1356:Tioctic acid
1345:
1204:
1181:
1169:
1157:
1129:
1114:Imiglucerase
1102:
1099:sphingolipid
1072:
1060:
1042:
1016:Mercaptamine
991:Ademetionine
922:
876:
872:
862:
850:. Retrieved
845:
819:. Retrieved
811:
783:. Retrieved
778:
752:. Retrieved
750:. 4 May 2016
745:
736:
724:. Retrieved
719:
710:
698:. Retrieved
693:
684:
663:
660:Legal status
625:
613:
592:
589:Medical uses
562:
558:
554:
553:
542:
234:Elimination
146:Legal status
140:Legal status
72:License data
18:
1346:Teduglutide
1326:Sapropterin
1188:Idursulfase
1159:iduronidase
1109:Alglucerase
1067:Sacrosidase
1039:Amino acids
1021:Metreleptin
982:Amino acids
666:orphan drug
555:Teduglutide
469: g·mol
406:CHEBI:72305
281:197922-42-2
246:Identifiers
227:Proteolysis
91:Teduglutide
44:Trade names
23:Teduglutide
1413:Categories
1321:Nitisinone
1286:Eliglustat
1176:Galsulfase
1164:Laronidase
1095:Glycolipid
1049:Pegvaliase
971:products (
969:metabolism
676:References
628:amino acid
599:parenteral
595:resections
474:3D model (
458:Molar mass
366:7M19191IKG
337:ChemSpider
317:IUPHAR/BPS
272:CAS Number
255:IUPAC name
222:Metabolism
1351:Trientine
1316:Nedosiran
1311:Miglustat
1306:Lumasiran
1291:Givosiran
1219:Phosphate
1006:Glutamine
649:secretion
561:(EU) and
559:Revestive
236:half-life
102:Routes of
64:Monograph
58:Drugs.com
1429:Peptides
1403:Medicine
903:22570676
852:20 March
821:20 March
785:20 March
779:DailyMed
726:31 March
545:(verify)
346:17296109
306:16139605
116:ATC code
86:DailyMed
1062:sucrase
1031:Enzymes
996:Betaine
894:3342570
754:7 April
700:9 April
672:(EMA).
636:glycine
632:alanine
579:mucosal
567:peptide
422:Formula
292:PubChem
171::
132:)
126: (
124:A16AX08
88::
1389:Portal
963:Other
901:
891:
563:Gattex
500:SMILES
386:D06053
185:℞-only
183:
173:℞-only
159:
84:
1274:Other
1201:Lipid
815:(EMA)
630:: an
520:InChI
476:JSmol
397:ChEBI
967:and
899:PMID
854:2024
823:2024
787:2024
756:2024
728:2024
702:2023
647:and
569:and
377:KEGG
357:UNII
326:7049
206:data
54:AHFS
973:A16
889:PMC
881:doi
467:.13
465:752
436:252
430:164
296:CID
216:88%
129:WHO
1415::
1221::
1203::
1156::
1101::
1085:,
1081:,
1059::
1041::
911:^
897:.
887:.
875:.
871:.
844:.
831:^
810:.
795:^
777:.
764:^
744:.
718:.
692:.
448:55
442:44
241:2h
191:EU
179:US
168:CA
161:S4
155:AU
81:US
1391::
1337:)
1333:(
1213:)
1209:(
1190:)
1186:(
1178:)
1174:(
1166:)
1162:(
1148:)
1134:(
1126:)
1107:(
1097:/
1089:)
1077:(
1069:)
1065:(
1051:)
1047:(
975:)
956:e
949:t
942:v
905:.
883::
877:5
856:.
825:.
789:.
758:.
730:.
704:.
478:)
463:3
451:S
445:O
439:N
433:H
427:C
193::
181::
157::
56:/
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