463:
706:(EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Tepmetko, intended for the treatment of people with advanced non-small cell lung cancer (NSCLC) harboring alterations leading to mesenchymal-epithelial transition factor gene exon 14 (METex14) skipping. The applicant for this medicinal product is Merck Europe. Tepotinib (Tepmetko) was approved for medical use in the European Union in February 2022.
40:
31:
5726:
1227:
1182:
887:
717:
designation. In
February 2024, the FDA converted the approval of tepotinib for adults with metastatic non-small cell lung cancer (NSCLC) harboring mesenchymal-epithelial transition (MET) exon 14 skipping alterations, to traditional approval. It was previously granted accelerated approval for this
685:. The most common treatment-related adverse effect in a 2021 study were peripheral edema (54.1%), nausea (20.0%), diarrhea (19.6%), blood creatinine increased (17.6%), and hypoalbuminemia (14.5%), which were 'mostly mild or moderate'.
872:
630:, meaning it is approved both for treatment-naive patients and for those in whom previous attempts at treatment have failed. US approval followed in February 2021. It is the second therapy approved by the US
1361:
218:
2792:
1075:
Morise M, Sakai H, Veillon R, Le X, Felip E, Garassino MC, et al. (July 2021). "O13-4 Tepotinib safety in MET exon 14 (METex14) skipping NSCLC: Updated results from the VISION trial".
798:
173:
578:
InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3
833:
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1347:
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1129:
5008:
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4303:
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1996:
975:"FDA Approves Tepmetko as the First and Only Once-daily Oral MET Inhibitor for Patients with Metastatic NSCLC with METex14 Skipping Alterations"
3288:
2971:
1142:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
1028:"FDA Approval Summary: Capmatinib and Tepotinib for the Treatment of Metastatic NSCLC Harboring MET Exon 14 Skipping Mutations or Alterations"
933:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
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914:
703:
674:
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1874:
1400:
3168:
669:
The most common side effects seen in clinical trials were edema, fatigue, nausea, diarrhea, muscle aches, and
1304:
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159:
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601:
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1449:
1339:
647:
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5018:
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1550:
1387:
1333:
for "Tepotinib Phase II in Non-small Cell Lung Cancer (NSCLC) Harboring MET Alterations (VISION)" at
4768:
2843:
718:
indication in
February 2021. The application was granted breakthrough and orphan drug designations.
458:
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1248:
Paik PK, Felip E, Veillon R, Sakai H, Cortot AB, Garassino MC, et al. (September 2020).
1005:"Tepmetko (Tepotinib) Approved in Japan for Advanced NSCLC with METex14 Skipping Alterations"
909:
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1680:
1522:
1517:
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1026:
Mathieu LN, Larkins E, Akinboro O, Roy P, Amatya AK, Fiero MH, et al. (January 2022).
383:
5730:
5108:
462:
863:"FDA grants accelerated approval to tepotinib for metastatic non-small cell lung cancer"
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280:
3-{1-pyrimidin2-yl}phenyl)methyl]-6-oxo-1,6-dihydropyridazin3-yl}benzonitrile
1088:
634:(FDA) to treat non-small cell lung cancer with these particular mutations, after
80:
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714:
88:
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1650:
1565:
1545:
1527:
1435:
635:
512:
354:
1096:
623:, and increase in creatinine level in the blood (a sign of kidney problems).
5506:
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5466:
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2016:
2011:
1978:
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1968:
1937:
1917:
1912:
1755:
1745:
1570:
1418:
1152:
74:
1289:
1053:
1270:
626:
Tepotinib first received marketing approval in Japan, in March 2020, as a
22:
5677:
5396:
5053:
4653:
4643:
4623:
4558:
4527:
4496:
4460:
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3703:
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3126:
3036:
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2067:
2006:
1962:
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1892:
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1430:
620:
334:
116:
343:
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670:
627:
309:
30:
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3283:
2961:
616:
422:
1153:
Advancing Health
Through Innovation: New Drug Therapy Approvals 2021
411:
403:
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3814:
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3597:
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3492:
3488:
3484:
3480:
3389:
3385:
3236:
2483:
2209:
2043:
1992:
1472:
1205:"FDA approves tepotinib for metastatic non-small cell lung cancer"
612:
535:
526:
1230:
This article incorporates text from this source, which is in the
1185:
This article incorporates text from this source, which is in the
890:
This article incorporates text from this source, which is in the
5068:
3674:
3670:
3666:
3662:
3658:
3654:
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3585:
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3577:
3573:
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3361:
3357:
3309:
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2598:
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1882:
1608:
1590:
1580:
1540:
1408:
1116:
1114:
658:
394:
248:
2774:
1343:
236:
111:
941:
939:
558:
CN1CCC(COc2cnc(-c3cccc(Cn4nc(-c5cccc(C#N)c5)ccc4=O)c3)nc2)CC1
765:"Updates to the Prescribing Medicines in Pregnancy database"
447:
212:
143:
1199:
1197:
1195:
225:
5668:
Pituitary adenylate cyclase-activating peptide (PACAP)
5714:
820:
818:
816:
5535:
5322:
5217:
4986:
4726:
4717:
4697:
4611:
4588:
4557:
4526:
4495:
4459:
4450:
4302:
4145:
4078:
4040:
3907:
3898:
3716:
3693:
3633:
3552:
3419:
3336:
3327:
3266:
3212:
3125:
2929:
2920:
2889:
2811:
2455:
2232:
1873:
1863:
1623:
1504:
1464:
1399:
1386:
654:(NSCLC) whose tumors have a mutation that leads to
524:
511:
478:
473:
441:
421:
393:
373:
353:
333:
308:
288:
263:
202:
197:
172:
158:
131:
101:
87:
69:
61:
51:
46:
5614:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
4472:Glial cell line-derived neurotrophic factor (GDNF)
4125:Cleavage products/derivatives with unknown target:
904:
902:
900:
5648:Macrophage-stimulating protein (MSP; HLP, HGFLP)
733:
731:
619:(feeling sick), low albumin level in the blood,
322:
3289:Heparin-binding EGF-like growth factor (HB-EGF)
2972:Heparin-binding EGF-like growth factor (HB-EGF)
297:
1250:"Tepotinib in Non-Small-Cell Lung Cancer with
857:
855:
853:
851:
791:"Summary Basis of Decision (SBD) for Tepmetko"
700:Committee for Medicinal Products for Human Use
5700:Additional growth factor receptor modulators:
2786:
1355:
8:
4054:Insulin-like growth factor-2 (somatomedin A)
3936:Insulin-like growth factor-2 (somatomedin A)
3926:Insulin-like growth factor-1 (somatomedin C)
713:(FDA) granted the application for tepotinib
673:. Like capmatinib, tepotinib can also cause
650:for the treatment of adults with metastatic
120:
21:
4723:
4456:
3904:
3333:
2926:
2793:
2779:
2771:
1870:
1396:
1362:
1348:
1340:
1007:(Press release). Merck KGaA. 25 March 2020
826:"Tepmetko- tepotinib hydrochloride tablet"
461:
362:
38:
29:
1279:
1269:
1043:
382:
5658:Migration-stimulating factor (MSF; PRG4)
969:
967:
5721:
2987:Transforming growth factor alpha (TGFα)
727:
575:
555:
457:
342:
277:
93:
5561:Connective tissue growth factor (CTGF)
769:Therapeutic Goods Administration (TGA)
743:Therapeutic Goods Administration (TGA)
604:used for the treatment of adults with
20:
5624:Hepatoma-derived growth factor (HDGF)
1132:from the original on 18 December 2021
836:from the original on 27 November 2021
611:The most common side effects include
430:
79:
7:
1170:from the original on 6 December 2022
985:from the original on 4 February 2021
951:Union Register of medicinal products
875:from the original on 3 February 2021
185:
5757:Receptor tyrosine kinase inhibitors
1258:The New England Journal of Medicine
410:
402:
313:
981:(Press release). 3 February 2021.
14:
5724:
5643:Leukemia inhibitory factor (LIF)
1225:
1180:
885:
801:from the original on 29 May 2022
496:
490:
4811:Negative allosteric modulators:
1122:"Tepmetko: Pending EC decision"
923:from the original on 5 May 2022
583:Key:AHYMHWXQRWRBKT-UHFFFAOYSA-N
5129:Gossypetin (3,5,7,8,3',4'-HHF)
4320:Platelet-derived growth factor
947:"Tepmetko Product information"
502:
484:
1:
5335:Placental growth factor (PGF)
1045:10.1158/1078-0432.CCR-21-1566
5619:Glia maturation factor (GMF)
4128:Glypromate (GPE, (1-3)IGF-1)
1323:. National Cancer Institute.
1311:. National Cancer Institute.
1211:Food and Drug Administration
1162:Food and Drug Administration
1089:10.1016/j.annonc.2021.05.541
868:Food and Drug Administration
711:Food and Drug Administration
632:Food and Drug Administration
596:, sold under the brand name
1254:Exon 14 Skipping Mutations"
683:toxic to a developing fetus
5773:
5551:Colony-stimulating factors
5543:Additional growth factors:
1865:Tyrosine kinase inhibitors
652:non-small cell lung cancer
606:non-small cell lung cancer
474:Chemical and physical data
4899:SNA-120 (pegylated K252a)
4071:(against IGF-1 and IGF-2)
4033:(against IGF-1 and IGF-2)
1731:Mirvetuximab soravtansine
1317:"Tepotinib hydrochloride"
1126:European Medicines Agency
915:European Medicines Agency
704:European Medicines Agency
675:interstitial lung disease
566:
546:
268:
37:
28:
3735:Hepatocyte growth factor
3294:Neuregulins (heregulins)
3225:Neuregulins (heregulins)
3169:Trastuzumab duocarmazine
2882:(against angiopoietin 2)
2876:(against angiopoietin 3)
1875:Receptor tyrosine kinase
1401:Receptor tyrosine kinase
1032:Clinical Cancer Research
3082:Depatuxizumab mafodotin
1465:Others for solid tumors
1371:Targeted cancer therapy
1166:(Report). 13 May 2022.
5705:(neurotrophin mixture)
5693:Wnt signaling proteins
5374:Allosteric modulators:
5094:Norwogonin (5,7,8-THF)
3314:5 (tomoregulin, TMEFF)
3164:Trastuzumab deruxtecan
2802:Growth factor receptor
1726:Loncastuximab tesirine
1455:Trastuzumab deruxtecan
1327:Clinical trial number
698:In December 2021, the
602:anti-cancer medication
5633:T-cell growth factors
3890:Telisotuzumab vedotin
3174:Trastuzumab emtansine
1801:Sacituzumab govitecan
1741:Moxetumomab pasudotox
1711:Inotuzumab ozogamicin
1614:Gemtuzumab ozogamicin
1450:Trastuzumab emtansine
1391:monoclonal antibodies
1375:antineoplastic agents
1271:10.1056/NEJMoa2004407
615:(build-up of fluid),
5747:Antineoplastic drugs
4218:EVT-901 (SAR-127963)
3951:Mecasermin rinfabate
1656:Belantamab mafodotin
1128:. 17 December 2021.
919:. 14 December 2021.
628:"line-agnostic" drug
2509:Denileukin diftitox
2171:(ALK, ROS1, NTRK),
1776:Polatuzumab vedotin
1766:Oportuzumab monatox
1321:NCI Drug Dictionary
1309:NCI Drug Dictionary
871:. 3 February 2021.
797:. 23 October 2014.
689:Society and culture
671:shortness of breath
221:(Prescription only)
25:
5384:Kinase inhibitors:
5247:Kinase inhibitors:
5146:Kinase inhibitors:
4821:Kinase inhibitors:
4636:Kinase inhibitors:
4596:Kinase inhibitors:
4577:Kinase inhibitors:
4546:Kinase inhibitors:
4515:Kinase inhibitors:
4484:Kinase inhibitors:
4344:Kinase inhibitors:
3958:Kinase inhibitors:
3752:Kinase inhibitors:
3541:Kinase inhibitors:
3534:Aprutumab ixadotin
3181:Kinase inhibitors:
2994:Kinase inhibitors:
2851:Kinase inhibitors:
2195:(ROS1, TRK, ALK),
1701:Enfortumab vedotin
1335:ClinicalTrials.gov
1215:. 15 February 2024
1077:Annals of Oncology
771:. 21 December 2022
5712:
5711:
5318:
5317:
5079:N-Acetylserotonin
4978:ReN-1820 (TrkAd5)
4607:
4606:
4141:
4140:
4086:Binding proteins:
3745:Dihexa (PNB-0408)
3712:
3711:
3323:
3322:
3237:6 (neuroglycan C)
2957:EGF (urogastrone)
2935:
2768:
2767:
2451:
2450:
1859:
1858:
1841:Tisotumab vedotin
745:. 27 January 2022
591:
590:
537:Interactive image
443:CompTox Dashboard
252:
240:
228:
216:
147:
114:
16:Chemical compound
5764:
5729:
5728:
5727:
5720:
5524:Decoy receptors:
5497:Alacizumab pegol
4975:Decoy receptors:
4724:
4629:Stem cell factor
4570:Persephin (PSPN)
4508:Neurturin (NRTN)
4457:
4294:LEVI-04 (p75-Fc)
4291:Decoy receptors:
3905:
3334:
2933:
2927:
2795:
2788:
2781:
2772:
2482:peptide against
2055:(AXL, ALK, LTK))
1871:
1681:Dinutuximab beta
1397:
1364:
1357:
1350:
1341:
1324:
1312:
1293:
1283:
1273:
1235:
1229:
1228:
1224:
1222:
1220:
1201:
1190:
1184:
1183:
1179:
1177:
1175:
1157:
1149:
1143:
1141:
1139:
1137:
1118:
1109:
1108:
1072:
1066:
1065:
1047:
1023:
1017:
1016:
1014:
1012:
1001:
995:
994:
992:
990:
971:
962:
961:
959:
957:
943:
934:
932:
930:
928:
906:
895:
889:
888:
884:
882:
880:
859:
846:
845:
843:
841:
822:
811:
810:
808:
806:
787:
781:
780:
778:
776:
761:
755:
754:
752:
750:
739:"Tepmetko APMDS"
735:
539:
519:
504:
498:
492:
486:
466:
465:
451:
449:
434:
414:
406:
386:
366:
346:
326:
316:
315:
301:
250:
247:
238:
235:
227:
224:
214:
211:
189:
145:
142:
124:
113:
110:
97:
83:
42:
33:
26:
24:
5772:
5771:
5767:
5766:
5765:
5763:
5762:
5761:
5737:
5736:
5735:
5725:
5723:
5715:
5713:
5708:
5653:Midkine (NEGF2)
5531:
5314:
5213:
4982:
4920:ABT-110 (PG110)
4713:
4693:
4603:
4584:
4553:
4522:
4491:
4446:
4298:
4236:ABT-110 (PG110)
4137:
4074:
4036:
3894:
3708:
3689:
3629:
3626:(against FGF23)
3548:
3415:
3319:
3262:
3208:
3121:
2932:
2916:
2885:
2807:
2799:
2769:
2764:
2618:Pi3K inhibitors
2516:mTOR inhibitors
2447:
2228:
2199:(VEGFR, FGFR),
1855:
1619:
1500:
1460:
1382:
1368:
1315:
1303:
1300:
1264:(10): 931–943.
1247:
1244:
1242:Further reading
1239:
1238:
1226:
1218:
1216:
1203:
1202:
1193:
1181:
1173:
1171:
1155:
1151:
1150:
1146:
1135:
1133:
1120:
1119:
1112:
1074:
1073:
1069:
1025:
1024:
1020:
1010:
1008:
1003:
1002:
998:
988:
986:
973:
972:
965:
955:
953:
945:
944:
937:
926:
924:
910:"Tepmetko EPAR"
908:
907:
898:
886:
878:
876:
861:
860:
849:
839:
837:
824:
823:
814:
804:
802:
789:
788:
784:
774:
772:
763:
762:
758:
748:
746:
737:
736:
729:
724:
696:
691:
667:
665:Adverse effects
644:
587:
584:
579:
574:
573:
562:
559:
554:
553:
542:
517:
507:
501:
495:
489:
469:
445:
437:
417:
389:
369:
349:
329:
312:
304:
284:
281:
276:
275:
259:
193:
161:
154:
151:Not recommended
134:
127:
17:
12:
11:
5:
5770:
5768:
5760:
5759:
5754:
5749:
5739:
5738:
5734:
5733:
5710:
5709:
5707:
5706:
5696:
5695:
5690:
5683:Thrombopoietin
5680:
5675:
5670:
5665:
5660:
5655:
5650:
5645:
5640:
5626:
5621:
5616:
5611:
5604:Erythropoietin
5601:
5563:
5558:
5548:
5546:Adrenomedullin
5539:
5537:
5533:
5532:
5530:
5529:
5520:
5519:
5514:
5509:
5504:
5499:
5490:
5489:
5484:
5479:
5474:
5469:
5464:
5459:
5454:
5449:
5444:
5439:
5434:
5429:
5424:
5419:
5414:
5409:
5404:
5399:
5394:
5389:
5380:
5379:
5370:
5369:
5347:
5342:
5337:
5328:
5326:
5320:
5319:
5316:
5315:
5313:
5312:
5307:
5302:
5297:
5292:
5287:
5282:
5277:
5272:
5267:
5262:
5257:
5252:
5243:
5242:
5237:
5232:
5223:
5221:
5215:
5214:
5212:
5211:
5206:
5201:
5196:
5191:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5151:
5142:
5141:
5132:
5131:
5126:
5121:
5112:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5041:
5036:
5031:
5026:
5021:
5016:
5011:
5009:4'-DMA-7,8-DHF
5006:
5001:
4992:
4990:
4984:
4983:
4981:
4980:
4971:
4970:
4958:
4957:
4952:
4947:
4942:
4937:
4932:
4927:
4922:
4903:
4902:
4896:
4891:
4886:
4881:
4876:
4871:
4866:
4861:
4856:
4851:
4846:
4841:
4836:
4831:
4826:
4817:
4816:
4807:
4806:
4801:
4796:
4791:
4782:
4781:
4776:
4771:
4769:Gambogic amide
4766:
4761:
4756:
4751:
4746:
4741:
4732:
4730:
4721:
4715:
4714:
4712:
4711:
4703:
4701:
4695:
4694:
4692:
4691:
4686:
4681:
4676:
4671:
4666:
4661:
4656:
4651:
4646:
4641:
4632:
4631:
4626:
4617:
4615:
4609:
4608:
4605:
4604:
4602:
4601:
4592:
4590:
4586:
4585:
4583:
4582:
4573:
4572:
4563:
4561:
4555:
4554:
4552:
4551:
4542:
4541:
4539:Artemin (ARTN)
4532:
4530:
4524:
4523:
4521:
4520:
4511:
4510:
4501:
4499:
4493:
4492:
4490:
4489:
4480:
4479:
4474:
4465:
4463:
4454:
4448:
4447:
4445:
4444:
4439:
4434:
4425:
4424:
4419:
4414:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4369:
4364:
4359:
4354:
4349:
4340:
4339:
4317:
4308:
4306:
4300:
4299:
4297:
4296:
4287:
4286:
4274:
4273:
4268:
4263:
4258:
4253:
4248:
4243:
4238:
4226:
4225:
4220:
4215:
4210:
4201:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4151:
4149:
4143:
4142:
4139:
4138:
4136:
4135:
4130:
4121:
4120:
4082:
4080:
4076:
4075:
4073:
4072:
4066:
4057:
4056:
4046:
4044:
4038:
4037:
4035:
4034:
4028:
4023:
4018:
4013:
4008:
4003:
3998:
3993:
3984:
3983:
3978:
3973:
3968:
3963:
3954:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3913:
3911:
3902:
3896:
3895:
3893:
3892:
3887:
3882:
3877:
3872:
3867:
3862:
3853:
3852:
3847:
3842:
3837:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3797:
3792:
3787:
3782:
3777:
3772:
3767:
3762:
3757:
3748:
3747:
3738:
3737:
3732:
3722:
3720:
3714:
3713:
3710:
3709:
3707:
3706:
3697:
3695:
3691:
3690:
3688:
3687:
3682:
3648:
3639:
3637:
3631:
3630:
3628:
3627:
3617:
3616:
3611:
3606:
3601:
3567:
3558:
3556:
3550:
3549:
3547:
3546:
3537:
3536:
3531:
3522:
3521:
3516:
3511:
3506:
3501:
3496:
3434:
3425:
3423:
3417:
3416:
3414:
3413:
3408:
3403:
3398:
3393:
3351:
3342:
3340:
3331:
3325:
3324:
3321:
3320:
3318:
3317:
3291:
3286:
3281:
3272:
3270:
3264:
3263:
3261:
3260:
3255:
3250:
3241:
3240:
3218:
3216:
3210:
3209:
3207:
3206:
3201:
3196:
3191:
3186:
3177:
3176:
3171:
3166:
3161:
3156:
3151:
3142:
3141:
3131:
3129:
3123:
3122:
3120:
3119:
3114:
3109:
3104:
3099:
3094:
3089:
3084:
3079:
3074:
3065:
3064:
3059:
3054:
3049:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3009:
3004:
2999:
2990:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2954:
2949:
2939:
2937:
2924:
2918:
2917:
2915:
2914:
2909:
2904:
2895:
2893:
2887:
2886:
2884:
2883:
2877:
2867:
2866:
2861:
2856:
2847:
2846:
2844:Angiopoietin 3
2841:
2839:Angiopoietin 2
2832:
2831:
2829:Angiopoietin 4
2826:
2824:Angiopoietin 1
2817:
2815:
2809:
2808:
2800:
2798:
2797:
2790:
2783:
2775:
2766:
2765:
2763:
2762:
2757:
2752:
2747:
2742:
2737:
2732:
2727:
2722:
2717:
2712:
2707:
2702:
2697:
2692:
2687:
2682:
2677:
2672:
2667:
2662:
2657:
2652:
2647:
2646:
2645:
2640:
2635:
2630:
2625:
2615:
2614:
2613:
2608:
2595:
2594:
2593:
2588:
2583:
2578:
2573:
2565:CDK inhibitors
2561:
2560:
2559:
2554:
2549:
2536:
2535:
2534:
2529:
2524:
2512:
2496:
2476:
2464:fusion protein
2459:
2457:
2453:
2452:
2449:
2448:
2446:
2445:
2444:
2443:
2438:
2433:
2428:
2423:
2410:
2409:
2408:
2407:
2402:
2397:
2380:
2379:
2378:
2377:
2372:
2367:
2362:
2349:
2348:
2347:
2346:
2341:
2336:
2331:
2326:
2321:
2316:
2303:
2302:
2296:
2284:
2283:
2282:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2238:
2236:
2230:
2229:
2227:
2226:
2205:
2204:
2203:(VEGFR, EGFR).
2159:
2158:
2157:
2156:
2151:
2146:
2133:
2132:
2131:
2130:
2125:
2120:
2115:
2110:
2105:
2100:
2095:
2090:
2085:
2080:
2075:
2070:
2057:
2056:
2040:
2034:
2029:
2024:
2019:
2014:
2009:
2004:
1984:
1983:
1982:
1981:
1976:
1971:
1961:HER1/EGFR and
1957:
1956:
1950:
1945:
1940:
1935:
1930:
1925:
1920:
1915:
1910:
1905:
1900:
1895:
1879:
1877:
1868:
1861:
1860:
1857:
1856:
1854:
1853:
1848:
1843:
1838:
1833:
1828:
1823:
1818:
1813:
1808:
1803:
1798:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1723:
1718:
1713:
1708:
1703:
1698:
1693:
1688:
1683:
1678:
1673:
1668:
1663:
1658:
1653:
1648:
1643:
1640:+hyaluronidase
1633:
1627:
1625:
1621:
1620:
1618:
1617:
1600:
1599:
1573:
1568:
1563:
1558:
1553:
1548:
1514:
1512:
1502:
1501:
1499:
1498:
1486:
1480:
1468:
1466:
1462:
1461:
1459:
1458:
1452:
1447:
1444:+hyaluronidase
1427:
1421:
1405:
1403:
1394:
1384:
1383:
1369:
1367:
1366:
1359:
1352:
1344:
1338:
1337:
1325:
1313:
1299:
1298:External links
1296:
1295:
1294:
1243:
1240:
1237:
1236:
1191:
1144:
1110:
1067:
1038:(2): 249–254.
1018:
996:
963:
935:
896:
847:
812:
782:
756:
726:
725:
723:
720:
702:(CHMP) of the
695:
692:
690:
687:
666:
663:
643:
640:
589:
588:
586:
585:
582:
580:
577:
569:
568:
567:
564:
563:
561:
560:
557:
549:
548:
547:
544:
543:
541:
540:
532:
530:
522:
521:
515:
509:
508:
505:
499:
493:
487:
482:
476:
475:
471:
470:
468:
467:
459:DTXSID70149132
454:
452:
439:
438:
436:
435:
427:
425:
419:
418:
416:
415:
407:
399:
397:
391:
390:
388:
387:
379:
377:
371:
370:
368:
367:
359:
357:
351:
350:
348:
347:
339:
337:
331:
330:
328:
327:
319:
317:
306:
305:
303:
302:
294:
292:
286:
285:
283:
282:
279:
271:
270:
269:
266:
265:
261:
260:
258:
257:
254:
245:
233:
222:
208:
206:
200:
199:
195:
194:
192:
191:
178:
176:
170:
169:
164:
162:administration
156:
155:
153:
152:
149:
139:
137:
129:
128:
126:
125:
107:
105:
99:
98:
91:
85:
84:
77:
67:
66:
63:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
5769:
5758:
5755:
5753:
5750:
5748:
5745:
5744:
5742:
5732:
5722:
5718:
5704:
5701:
5698:
5697:
5694:
5691:
5688:
5684:
5681:
5679:
5676:
5674:
5671:
5669:
5666:
5664:
5661:
5659:
5656:
5654:
5651:
5649:
5646:
5644:
5641:
5638:
5634:
5630:
5627:
5625:
5622:
5620:
5617:
5615:
5612:
5609:
5605:
5602:
5599:
5595:
5591:
5587:
5583:
5579:
5575:
5571:
5567:
5564:
5562:
5559:
5556:
5552:
5549:
5547:
5544:
5541:
5540:
5538:
5534:
5528:
5525:
5522:
5521:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5492:
5491:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5443:
5440:
5438:
5435:
5433:
5430:
5428:
5425:
5423:
5420:
5418:
5415:
5413:
5410:
5408:
5405:
5403:
5400:
5398:
5395:
5393:
5390:
5388:
5385:
5382:
5381:
5378:
5377:Cyclotraxin B
5375:
5372:
5371:
5367:
5363:
5359:
5355:
5351:
5348:
5346:
5343:
5341:
5338:
5336:
5333:
5330:
5329:
5327:
5325:
5321:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5291:
5290:Larotrectinib
5288:
5286:
5283:
5281:
5278:
5276:
5273:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5251:
5248:
5245:
5244:
5241:
5238:
5236:
5233:
5231:
5228:
5225:
5224:
5222:
5220:
5216:
5210:
5207:
5205:
5202:
5200:
5197:
5195:
5192:
5190:
5189:Larotrectinib
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5144:
5143:
5140:
5137:
5134:
5133:
5130:
5127:
5125:
5124:Cyclotraxin B
5122:
5120:
5117:
5114:
5113:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5034:Amitriptyline
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5010:
5007:
5005:
5002:
5000:
4997:
4994:
4993:
4991:
4989:
4985:
4979:
4976:
4973:
4972:
4969:
4966:
4963:
4960:
4959:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4914:
4911:
4910:Against TrkA:
4908:
4905:
4904:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4864:Larotrectinib
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4819:
4818:
4815:
4812:
4809:
4808:
4805:
4802:
4800:
4797:
4795:
4794:Dexamethasone
4792:
4790:
4787:
4784:
4783:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4739:Amitriptyline
4737:
4734:
4733:
4731:
4729:
4725:
4722:
4720:
4716:
4709:
4705:
4704:
4702:
4700:
4696:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4665:
4662:
4660:
4657:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4637:
4634:
4633:
4630:
4627:
4625:
4622:
4619:
4618:
4616:
4614:
4610:
4600:
4597:
4594:
4593:
4591:
4587:
4581:
4578:
4575:
4574:
4571:
4568:
4565:
4564:
4562:
4560:
4556:
4550:
4547:
4544:
4543:
4540:
4537:
4534:
4533:
4531:
4529:
4525:
4519:
4516:
4513:
4512:
4509:
4506:
4503:
4502:
4500:
4498:
4494:
4488:
4485:
4482:
4481:
4478:
4475:
4473:
4470:
4467:
4466:
4464:
4462:
4458:
4455:
4453:
4449:
4443:
4440:
4438:
4435:
4433:
4430:
4427:
4426:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4385:
4383:
4380:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4358:
4355:
4353:
4350:
4348:
4345:
4342:
4341:
4337:
4333:
4329:
4325:
4321:
4318:
4316:
4313:
4310:
4309:
4307:
4305:
4301:
4295:
4292:
4289:
4288:
4285:
4282:
4279:
4276:
4275:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4234:
4231:
4228:
4227:
4224:
4221:
4219:
4216:
4214:
4213:Dexamethasone
4211:
4209:
4206:
4203:
4202:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4153:
4152:
4150:
4148:
4144:
4134:
4131:
4129:
4126:
4123:
4122:
4118:
4114:
4110:
4106:
4102:
4098:
4094:
4090:
4087:
4084:
4083:
4081:
4077:
4070:
4067:
4065:
4062:
4059:
4058:
4055:
4051:
4048:
4047:
4045:
4043:
4039:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3986:
3985:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3956:
3955:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3921:des(1-3)IGF-1
3918:
3915:
3914:
3912:
3910:
3906:
3903:
3901:
3897:
3891:
3888:
3886:
3885:Telisotuzumab
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3855:
3854:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3750:
3749:
3746:
3743:
3742:Potentiators:
3740:
3739:
3736:
3733:
3731:
3727:
3724:
3723:
3721:
3719:
3715:
3705:
3702:
3699:
3698:
3696:
3692:
3686:
3683:
3680:
3676:
3672:
3668:
3664:
3660:
3656:
3652:
3649:
3647:
3644:
3641:
3640:
3638:
3636:
3632:
3625:
3622:
3619:
3618:
3615:
3612:
3610:
3607:
3605:
3604:Selpercatinib
3602:
3599:
3595:
3591:
3587:
3583:
3579:
3575:
3571:
3568:
3566:
3563:
3560:
3559:
3557:
3555:
3551:
3545:
3542:
3539:
3538:
3535:
3532:
3530:
3527:
3524:
3523:
3520:
3517:
3515:
3512:
3510:
3509:Selpercatinib
3507:
3505:
3502:
3500:
3497:
3494:
3490:
3486:
3482:
3478:
3474:
3470:
3466:
3462:
3458:
3454:
3450:
3446:
3442:
3438:
3435:
3433:
3430:
3427:
3426:
3424:
3422:
3418:
3412:
3409:
3407:
3404:
3402:
3401:Selpercatinib
3399:
3397:
3394:
3391:
3387:
3383:
3379:
3375:
3371:
3367:
3363:
3359:
3355:
3352:
3350:
3347:
3344:
3343:
3341:
3339:
3335:
3332:
3330:
3326:
3315:
3311:
3307:
3303:
3299:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3274:
3273:
3271:
3269:
3265:
3259:
3256:
3254:
3251:
3249:
3246:
3243:
3242:
3238:
3234:
3230:
3226:
3223:
3220:
3219:
3217:
3215:
3211:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3185:
3182:
3179:
3178:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3144:
3143:
3140:
3136:
3133:
3132:
3130:
3128:
3124:
3118:
3115:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3085:
3083:
3080:
3078:
3077:Depatuxizumab
3075:
3073:
3070:
3067:
3066:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2992:
2991:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2944:
2941:
2940:
2938:
2936:
2928:
2925:
2923:
2919:
2913:
2910:
2908:
2905:
2903:
2900:
2897:
2896:
2894:
2892:
2888:
2881:
2878:
2875:
2872:
2869:
2868:
2865:
2862:
2860:
2857:
2855:
2852:
2849:
2848:
2845:
2842:
2840:
2837:
2834:
2833:
2830:
2827:
2825:
2822:
2819:
2818:
2816:
2814:
2810:
2806:
2803:
2796:
2791:
2789:
2784:
2782:
2777:
2776:
2773:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2701:
2698:
2696:
2693:
2691:
2688:
2686:
2683:
2681:
2678:
2676:
2675:Larotrectinib
2673:
2671:
2668:
2666:
2663:
2661:
2658:
2656:
2653:
2651:
2648:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2620:
2619:
2616:
2612:
2609:
2607:
2604:
2603:
2602:
2600:
2596:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2568:
2567:
2566:
2562:
2558:
2555:
2553:
2550:
2548:
2545:
2544:
2543:
2541:
2537:
2533:
2530:
2528:
2527:Ridaforolimus
2525:
2523:
2520:
2519:
2518:
2517:
2513:
2510:
2506:
2505:
2501:
2497:
2494:
2490:
2489:
2485:
2481:
2477:
2474:
2470:
2469:
2465:
2461:
2460:
2458:
2454:
2442:
2439:
2437:
2436:Pirtobrutinib
2434:
2432:
2431:Orelabrutinib
2429:
2427:
2424:
2422:
2421:Acalabrutinib
2419:
2418:
2417:
2416:
2412:
2411:
2406:
2403:
2401:
2398:
2396:
2393:
2392:
2391:
2390:
2386:
2382:
2381:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2357:
2356:
2355:
2351:
2350:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2311:
2310:
2309:
2305:
2304:
2300:
2297:
2295:
2291:
2290:
2286:
2285:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2246:
2245:
2244:
2240:
2239:
2237:
2235:
2231:
2224:
2220:
2216:
2213:
2211:
2207:
2206:
2202:
2198:
2197:Selpercatinib
2194:
2193:Repotrectinib
2190:
2186:
2182:
2181:Larotrectinib
2178:
2174:
2170:
2167:
2165:
2161:
2160:
2155:
2152:
2150:
2147:
2145:
2142:
2141:
2140:
2139:
2135:
2134:
2129:
2126:
2124:
2121:
2119:
2116:
2114:
2111:
2109:
2106:
2104:
2101:
2099:
2096:
2094:
2091:
2089:
2086:
2084:
2081:
2079:
2076:
2074:
2071:
2069:
2066:
2065:
2064:
2063:
2059:
2058:
2054:
2050:
2046:
2045:
2041:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
1999:
1998:
1994:
1989:
1988:RTK class III
1986:
1985:
1980:
1977:
1975:
1972:
1970:
1967:
1966:
1965:
1964:
1959:
1958:
1954:
1951:
1949:
1946:
1944:
1941:
1939:
1936:
1934:
1931:
1929:
1926:
1924:
1921:
1919:
1916:
1914:
1911:
1909:
1906:
1904:
1901:
1899:
1896:
1894:
1890:
1889:
1884:
1881:
1880:
1878:
1876:
1872:
1869:
1866:
1862:
1852:
1849:
1847:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1827:
1824:
1822:
1819:
1817:
1814:
1812:
1809:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1771:Pembrolizumab
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1736:Mogamulizumab
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1687:
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1641:
1637:
1634:
1632:
1629:
1628:
1626:
1622:
1615:
1611:
1610:
1605:
1602:
1601:
1597:
1593:
1592:
1587:
1583:
1582:
1577:
1574:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1556:Mosunetuzumab
1554:
1552:
1549:
1547:
1543:
1542:
1537:
1536:Mosunetuzumab
1533:
1529:
1525:
1524:
1519:
1516:
1515:
1513:
1511:
1507:
1503:
1496:
1492:
1491:
1487:
1484:
1481:
1479:
1475:
1474:
1470:
1469:
1467:
1463:
1456:
1453:
1451:
1448:
1445:
1441:
1437:
1433:
1432:
1428:
1425:
1422:
1420:
1416:
1415:
1410:
1407:
1406:
1404:
1402:
1398:
1395:
1392:
1389:
1385:
1380:
1376:
1372:
1365:
1360:
1358:
1353:
1351:
1346:
1345:
1342:
1336:
1332:
1331:
1326:
1322:
1318:
1314:
1310:
1306:
1302:
1301:
1297:
1291:
1287:
1282:
1277:
1272:
1267:
1263:
1259:
1255:
1253:
1246:
1245:
1241:
1233:
1232:public domain
1214:
1212:
1206:
1200:
1198:
1196:
1192:
1188:
1187:public domain
1169:
1165:
1163:
1154:
1148:
1145:
1131:
1127:
1123:
1117:
1115:
1111:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1071:
1068:
1063:
1059:
1055:
1051:
1046:
1041:
1037:
1033:
1029:
1022:
1019:
1006:
1000:
997:
984:
980:
976:
970:
968:
964:
952:
948:
942:
940:
936:
922:
918:
916:
911:
905:
903:
901:
897:
893:
892:public domain
874:
870:
869:
864:
858:
856:
854:
852:
848:
835:
831:
827:
821:
819:
817:
813:
800:
796:
795:Health Canada
792:
786:
783:
770:
766:
760:
757:
744:
740:
734:
732:
728:
721:
719:
716:
712:
707:
705:
701:
693:
688:
686:
684:
680:
676:
672:
664:
662:
661:14 skipping.
660:
657:
653:
649:
646:Tepotinib is
641:
639:
637:
633:
629:
624:
622:
618:
614:
609:
607:
603:
599:
595:
581:
576:
572:
565:
556:
552:
545:
538:
534:
533:
531:
528:
523:
516:
514:
510:
483:
481:
477:
472:
464:
460:
456:
455:
453:
444:
440:
433:
432:ChEMBL3402762
429:
428:
426:
424:
420:
413:
409:as HCl:
408:
405:
401:
400:
398:
396:
392:
385:
381:
380:
378:
376:
372:
365:
361:
360:
358:
356:
352:
345:
341:
340:
338:
336:
332:
325:
321:
320:
318:
311:
307:
300:
296:
295:
293:
291:
287:
278:
274:
267:
262:
255:
253: Rx-only
246:
244:
234:
232:
223:
220:
210:
209:
207:
205:
201:
196:
188:
183:
180:
179:
177:
175:
171:
168:
165:
163:
157:
150:
141:
140:
138:
136:
130:
123:
118:
109:
108:
106:
104:
100:
96:
92:
90:
86:
82:
78:
76:
72:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
5752:Orphan drugs
5703:Cerebrolysin
5699:
5673:Pleiotrophin
5629:Interleukins
5542:
5523:
5493:
5412:Fruquintinib
5402:Cabozantinib
5383:
5373:
5331:
5295:Lestaurtinib
5246:
5226:
5194:Lestaurtinib
5145:
5135:
5116:Antagonists:
5115:
5049:Deoxygedunin
5004:3,7,8,2'-THF
4995:
4974:
4965:Against NGF:
4964:
4961:
4917:Against NGF:
4916:
4909:
4906:
4869:Lestaurtinib
4820:
4810:
4804:Testosterone
4786:Antagonists:
4785:
4735:
4635:
4620:
4595:
4576:
4566:
4545:
4535:
4514:
4504:
4483:
4468:
4428:
4343:
4311:
4290:
4281:Against NGF:
4280:
4277:
4233:Against NGF:
4232:
4229:
4223:Testosterone
4205:Antagonists:
4204:
4154:
4124:
4085:
4060:
4049:
4026:Teprotumumab
3987:
3957:
3916:
3865:Ficlatuzumab
3860:Emibetuzumab
3856:
3810:JNJ-38877605
3780:Cabozantinib
3751:
3741:
3730:Fosgonimeton
3725:
3700:
3642:
3620:
3561:
3544:Infigratinib
3540:
3525:
3428:
3345:
3279:Betacellulin
3275:
3258:Seribantumab
3244:
3221:
3180:
3145:
3139:Unknown/none
3138:
3134:
3068:
2993:
2952:Betacellulin
2947:Amphiregulin
2942:
2934:(ErbB1/HER1)
2898:
2870:
2850:
2836:Antagonists:
2835:
2820:
2813:Angiopoietin
2749:
2715:Pexidartinib
2700:Odronextamab
2670:Gilteritinib
2650:Cabozantinib
2597:
2563:
2538:
2532:Temsirolimus
2514:
2498:
2480:proapoptotic
2478:
2462:
2441:Zanubrutinib
2413:
2383:
2352:
2329:Lestaurtinib
2308:Janus kinase
2306:
2287:
2241:
2234:Non-receptor
2215:Cabozantinib
2208:
2177:Infigratinib
2162:
2136:
2078:Fruquintinib
2060:
2053:Gilteritinib
2049:Lestaurtinib
2042:
1991:
1960:
1933:Mobocertinib
1898:Aumolertinib
1886:
1851:Tremelimumab
1836:Tislelizumab
1791:Retifanlimab
1666:Blinatumomab
1636:Atezolizumab
1607:
1589:
1579:
1561:Obinutuzumab
1539:
1521:
1488:
1471:
1429:
1412:
1328:
1320:
1308:
1261:
1257:
1251:
1217:. Retrieved
1208:
1172:. Retrieved
1159:
1147:
1134:. Retrieved
1125:
1080:
1076:
1070:
1035:
1031:
1021:
1009:. Retrieved
999:
987:. Retrieved
978:
954:. Retrieved
950:
925:. Retrieved
913:
877:. Retrieved
866:
838:. Retrieved
829:
803:. Retrieved
794:
785:
773:. Retrieved
768:
759:
747:. Retrieved
742:
708:
697:
694:Legal status
679:liver damage
668:
645:
642:Medical uses
625:
610:
597:
593:
592:
299:1100598-32-0
204:Legal status
198:Legal status
103:License data
18:
5663:Oncomodulin
5527:Aflibercept
5517:Ranibizumab
5512:Ramucirumab
5502:Bevacizumab
5494:Antibodies:
5452:Regorafenib
5392:Altiratinib
5305:ONO-5390556
5275:Entrectinib
5250:Altiratinib
5204:ONO-5390556
5174:Entrectinib
5149:Altiratinib
4935:Frunevetmab
4907:Antibodies:
4884:ONO-5390556
4849:Entrectinib
4824:Altiratinib
4779:Tavilermide
4674:Quizartinib
4613:SCF (c-Kit)
4437:Ramucirumab
4429:Antibodies:
4402:Quizartinib
4352:Avapritinib
4315:Becaplermin
4251:Frunevetmab
4230:Antibodies:
4133:Trofinetide
4064:Dusigitumab
4061:Antibodies:
4016:Robatumumab
4006:Figitumumab
4001:Dalotuzumab
3996:Cixutumumab
3988:Antibodies:
3880:Rilotumumab
3875:Onartuzumab
3870:Flanvotumab
3857:Antibodies:
3825:PF-04217903
3755:Altiratinib
3718:HGF (c-Met)
3621:Antibodies:
3526:Antibodies:
3248:Duligotumab
3245:Antibodies:
3159:Trastuzumab
3149:Ertumaxomab
3146:Antibodies:
3117:Zalutumumab
3112:Panitumumab
3107:Nimotuzumab
3102:Necitumumab
3092:Imgatuzumab
3069:Antibodies:
3052:Osimertinib
3017:Dacomitinib
2912:Dapiclermin
2871:Antibodies:
2854:Altiratinib
2745:Tebentafusp
2725:Regorafenib
2720:Quizartinib
2710:Pemigatinib
2690:Midostaurin
2665:Erdafitinib
2660:Entrectinib
2643:Parsaclisib
2591:Trilaciclib
2581:Palbociclib
2576:Dalpiciclib
2571:Abemaciclib
2473:Aflibercept
2400:Entrectinib
2370:Selumetinib
2365:Cobimetinib
2360:Binimetinib
2344:Ruxolitinib
2334:Momelotinib
2314:Baricitinib
2212:inhibitors:
2189:Pralsetinib
2185:Pemigatinib
2173:Futibatinib
2169:Entrectinib
2166:inhibitors:
2098:Regorafenib
2002:Avapritinib
1948:Rociletinib
1943:Osimertinib
1908:Dacomitinib
1846:Toripalimab
1831:Teclistamab
1821:Talquetamab
1816:Tafasitamab
1811:Sugemalimab
1806:Serplulimab
1796:Sabatolimab
1786:Ramucirumab
1781:Prolgolimab
1751:Necitumumab
1706:Epcoritamab
1686:Dostarlimab
1676:Daratumumab
1631:Amivantamab
1596:Alemtuzumab
1586:Brentuximab
1576:Tositumomab
1551:Ibritumomab
1532:Elranatamab
1495:Bevacizumab
1483:Edrecolomab
1478:Catumaxomab
1440:Trastuzumab
1424:Panitumumab
1330:NCT02864992
1305:"Tepotinib"
1219:19 February
1136:18 December
840:13 February
715:orphan drug
520: g·mol
264:Identifiers
89:MedlinePlus
65:EMD-1214063
62:Other names
53:Trade names
5741:Categories
5482:Vandetanib
5447:Rebastinib
5442:Pegaptanib
5432:Nintedanib
5422:Lenvatinib
5387:Agerafenib
5340:Ripretinib
5265:CH-7057288
5164:CH-7057288
5029:7,8,3'-THF
5024:7,8,2'-THF
4950:Ranevetmab
4940:Fulranumab
4894:Rebastinib
4839:CH-7057288
4754:Cenegermin
4639:Agerafenib
4599:Agerafenib
4580:Vandetanib
4549:Vandetanib
4518:Vandetanib
4487:Vandetanib
4432:Olaratumab
4407:Ripretinib
4387:Nintedanib
4372:Lenvatinib
4362:Crenolanib
4347:Agerafenib
4266:Ranevetmab
4256:Fulranumab
4173:Cenegermin
4147:LNGF (p75)
4069:Xentuzumab
4031:Xentuzumab
3976:NVP-AEW541
3971:NVP-ADW742
3966:Linsitinib
3961:BMS-754807
3946:Mecasermin
3845:Tivantinib
3835:PHA-665752
3830:PF-2341066
3800:Golvatinib
3790:Crizotinib
3785:Capmatinib
3775:BMS-777607
3770:Amuvatinib
3646:Ersofermin
3609:Sprifermin
3565:Ersofermin
3514:Sprifermin
3504:Repifermin
3499:Palifermin
3432:Ersofermin
3411:Velafermin
3396:Repifermin
3349:Ersofermin
3268:ErbB4/HER4
3253:Patritumab
3214:ErbB3/HER3
3194:Mubritinib
3154:Pertuzumab
3127:ErbB2/HER2
3057:Vandetanib
3012:Canertinib
3007:Brigatinib
3002:Agerafenib
2982:Nepidermin
2977:Murodermin
2967:Epiregulin
2922:EGF (ErbB)
2880:Nesvacumab
2874:Evinacumab
2864:Rebastinib
2805:modulators
2760:Venetoclax
2755:Vandetanib
2730:Ripretinib
2695:Nintedanib
2680:Lenvatinib
2655:Capmatinib
2638:Idelalisib
2628:Copanlisib
2601:inhibitors
2586:Ribociclib
2557:Vismodegib
2542:inhibitors
2522:Everolimus
2488:prohibitin
2405:Lorlatinib
2395:Crizotinib
2375:Trametinib
2339:Pacritinib
2324:Filgotinib
2319:Fedratinib
2223:Crizotinib
2219:Capmatinib
2201:Vandetanib
2149:Brigatinib
2128:Vandetanib
2088:Nintedanib
2083:Lenvatinib
2022:Ripretinib
1953:Vandetanib
1928:Lazertinib
1903:Brigatinib
1826:Tarlatamab
1761:Olaratumab
1721:Isatuximab
1716:Ipilimumab
1696:Elotuzumab
1691:Durvalumab
1671:Cemiplimab
1661:Bermekimab
1651:Axatilimab
1566:Ofatumumab
1546:Glofitamab
1528:Glofitamab
1436:Pertuzumab
1174:22 January
1011:3 February
989:3 February
979:EMD Serono
879:3 February
749:5 February
722:References
636:capmatinib
525:3D model (
513:Molar mass
384:1IJV77EI07
355:ChemSpider
290:CAS Number
273:IUPAC name
5507:Icrucumab
5487:WHI-P 154
5477:Tivozanib
5472:Toceranib
5467:Sunitinib
5462:Sorafenib
5457:Semaxanib
5437:Pazopanib
5427:Motesanib
5417:Lapatinib
5407:Cediranib
5345:Telbermin
5332:Agonists:
5280:GZ-389988
5260:CE-245677
5227:Agonists:
5179:GZ-389988
5159:CE-245677
5059:Diosmetin
4996:Agonists:
4962:Aptamers:
4955:Tanezumab
4930:Fasinumab
4874:Milciclib
4854:GZ-389988
4834:CE-245677
4736:Agonists:
4689:Toceranib
4684:Sunitinib
4679:Sorafenib
4669:Pazopanib
4664:Nilotinib
4659:Masitinib
4649:Dasatinib
4621:Agonists:
4567:Agonists:
4536:Agonists:
4505:Agonists:
4477:Liatermin
4469:Agonists:
4452:RET (GFL)
4442:Tovetumab
4422:Toceranib
4417:Sorafenib
4412:Sunitinib
4397:Radotinib
4392:Pazopanib
4382:Motesanib
4377:Masitinib
4312:Agonists:
4278:Aptamers:
4271:Tanezumab
4246:Fasinumab
4155:Agonists:
4011:Ganitumab
3931:IGF-1 LR3
3850:Volitinib
3805:INCB28060
3795:Foretinib
3701:Agonists:
3685:Trafermin
3643:Agonists:
3624:Burosumab
3614:Trafermin
3562:Agonists:
3529:Aprutumab
3519:Trafermin
3481:10 (KGF2)
3429:Agonists:
3406:Trafermin
3386:10 (KGF2)
3346:Agonists:
3276:Agonists:
3222:Agonists:
3204:Tucatinib
3199:Neratinib
3189:Lapatinib
3097:Matuzumab
3087:Futuximab
3072:Cetuximab
3062:WHI-P 154
3047:Neratinib
3042:Lapatinib
3032:Grandinin
3027:Gefitinib
3022:Erlotinib
2899:Agonists:
2859:CE-245677
2821:Agonists:
2750:Tepotinib
2740:Sunitinib
2735:Sorafenib
2705:Pazopanib
2685:Masitinib
2633:Duvelisib
2623:Alpelisib
2611:Sotorasib
2606:Adagrasib
2552:Sonidegib
2547:Glasdegib
2493:Adipotide
2426:Ibrutinib
2299:Dasatinib
2294:Bosutinib
2279:Radotinib
2274:Ponatinib
2269:Nilotinib
2259:Dasatinib
2254:Bosutinib
2249:Asciminib
2217:(VEGFR),
2175:(FGFR2),
2154:Ceritinib
2144:Alectinib
2123:Toceranib
2118:Tivozanib
2113:Sunitinib
2108:Sorafenib
2103:Semaxanib
2093:Pazopanib
2073:Cediranib
2037:Toceranib
2032:Sunitinib
2027:Sorafenib
2017:Pazopanib
2012:Masitinib
1979:Tucatinib
1974:Neratinib
1969:Lapatinib
1938:Olmutinib
1918:Gefitinib
1913:Erlotinib
1888:HER1/EGFR
1756:Nivolumab
1746:Naxitamab
1571:Rituximab
1419:Cetuximab
1414:HER1/EGFR
1105:237785148
1097:0923-7534
1062:236915283
775:2 January
681:, and is
648:indicated
608:(NSCLC).
594:Tepotinib
160:Routes of
133:Pregnancy
122:Tepotinib
81:Monograph
75:Drugs.com
23:Tepotinib
5731:Medicine
5689:instead)
5678:Renalase
5639:instead)
5610:instead)
5557:instead)
5397:Axitinib
5366:D (FIGF)
5310:PLX-7486
5300:ONO-4474
5255:AZD-6918
5209:PLX-7486
5199:ONO-4474
5154:AZD-6918
5136:Ligands:
5054:Deprenyl
5014:7,3'-DHF
4945:MEDI-578
4925:ASP-6294
4889:PLX-7486
4879:ONO-4474
4829:AZD-6918
4789:ALE-0540
4710:instead.
4654:Imatinib
4644:Axitinib
4624:Ancestim
4589:Unsorted
4367:Imatinib
4357:Axitinib
4261:MEDI-578
4241:ASP-6294
4208:ALE-0540
4050:Agonists
3991:AVE-1642
3917:Agonists
3840:SU-11274
3726:Agonists
3704:FGF15/19
3694:Unsorted
3659:2 (bFGF)
3578:2 (bFGF)
3445:2 (bFGF)
3362:2 (bFGF)
3184:Afatinib
3135:Agonists
3037:Icotinib
2997:Afatinib
2943:Agonists
2540:hedgehog
2502:against
2500:exotoxin
2466:against
2415:Bruton's
2264:Imatinib
2187:(FGFR),
2183:(NTRK),
2068:Axitinib
2007:Axitinib
1963:HER2/neu
1923:Icotinib
1893:Afatinib
1867:("-nib")
1646:Avelumab
1518:lymphoid
1510:lymphoma
1506:Leukemia
1431:HER2/neu
1393:("-mab")
1290:32469185
1168:Archived
1130:Archived
1083:: S291.
1054:34344795
983:Archived
921:Archived
873:Archived
834:Archived
830:DailyMed
799:Archived
621:diarrhea
600:, is an
598:Tepmetko
364:25069712
335:DrugBank
324:25171648
174:ATC code
167:By mouth
135:category
117:DailyMed
57:Tepmetko
5566:Ephrins
5270:DS-6051
5169:DS-6051
5074:LM22A-4
5064:DMAQ-B1
5019:7,8-DHF
4999:3,7-DHF
4968:RBM-004
4913:GBR-900
4844:DS-6051
4814:VM-902A
4284:RBM-004
3981:OSl-906
3941:Insulin
3820:MK-2461
3765:AMG-458
2902:Axokine
2243:bcr-abl
1604:myeloid
1281:8422679
956:3 March
709:The US
518:492.583
480:Formula
344:DB15133
310:PubChem
256:Rx-only
229::
190:)
184: (
182:L01EX21
148: D
119::
95:a621012
5717:Portal
5536:Others
5230:BNN-20
5119:ANA-12
5044:BNN-20
4764:DHEA-S
4749:BNN-27
4744:BNN-20
4183:DHEA-S
4168:BNN-27
4163:BNN-20
4079:Others
3284:Epigen
2962:Epigen
1490:VEGF-A
1288:
1278:
1103:
1095:
1060:
1052:
805:29 May
617:nausea
551:SMILES
423:ChEMBL
412:D11073
404:D11717
243:℞-only
241:
231:℞-only
217:
115:
5685:(see
5635:(see
5606:(see
5553:(see
5285:K252a
5184:K252a
4859:K252a
4799:FX007
4559:GFRα4
4528:GFRα3
4497:GFRα2
4461:GFRα1
4089:IGFBP
4042:IGF-2
4021:R1507
3909:IGF-1
3815:K252a
3635:FGFR4
3554:FGFR3
3421:FGFR2
3338:FGFR1
2484:ANXA2
2456:Other
2354:MAP2K
2225:(ALK)
2210:c-MET
2062:VEGFR
1997:PDGFR
1993:C-kit
1624:Other
1473:EpCAM
1213:(FDA)
1209:U.S.
1164:(FDA)
1160:U.S.
1156:(PDF)
1101:S2CID
1058:S2CID
927:5 May
917:(EMA)
613:edema
571:InChI
527:JSmol
5687:here
5637:here
5608:here
5555:here
5350:VEGF
5324:VEGF
5240:NT-3
5235:DHEA
5219:TrkC
5139:DHEA
5109:TDP6
5089:NT-4
5084:NT-3
5069:HIOC
5039:BDNF
4988:TrkB
4759:DHEA
4728:TrkA
4708:here
4706:See
4699:TGFβ
4304:PDGF
4198:NT-4
4193:NT-3
4178:DHEA
4158:BDNF
2907:CNTF
2891:CNTF
2599:KRAS
2504:IL-2
2486:and
2468:VEGF
2385:EML4
2044:FLT3
1995:and
1883:ErbB
1609:CD33
1591:CD52
1581:CD30
1541:CD20
1409:ErbB
1286:PMID
1221:2024
1176:2023
1138:2021
1093:ISSN
1050:PMID
1013:2021
991:2021
958:2023
929:2022
881:2021
842:2021
807:2022
777:2023
751:2022
677:and
659:exon
395:KEGG
375:UNII
71:AHFS
5104:R13
4774:NGF
4719:Trk
4188:NGF
3900:IGF
3760:AM7
3651:FGF
3570:FGF
3471:),
3469:KGF
3437:FGF
3354:FGF
3329:FGF
2931:EGF
2389:ALK
2289:Src
2164:RET
2138:ALK
1588:),
1578:),
1538:),
1523:CD3
1379:L01
1276:PMC
1266:doi
1262:383
1252:MET
1085:doi
1040:doi
656:MET
448:EPA
314:CID
187:WHO
5743::
5598:B3
5596:,
5594:B2
5592:,
5590:B1
5588:,
5586:A5
5584:,
5582:A4
5580:,
5578:A3
5576:,
5574:A2
5572:,
5570:A1
5364:,
5360:,
5356:,
5099:R7
4915:;
4334:,
4330:,
4326:,
4115:,
4111:,
4107:,
4103:,
4099:,
4095:,
4052::
3919::
3728::
3679:19
3677:,
3673:,
3669:,
3665:,
3661:,
3657:,
3598:23
3596:,
3594:18
3592:,
3588:,
3584:,
3580:,
3576:,
3493:22
3491:,
3489:18
3487:,
3485:17
3483:,
3479:,
3475:,
3463:,
3459:,
3455:,
3451:,
3447:,
3443:,
3390:20
3388:,
3384:,
3380:,
3376:,
3372:,
3368:,
3364:,
3360:,
3312:,
3308:,
3304:,
3300:,
3235:,
3231:,
3137::
2945::
2221:,
2191:,
2179:,
2051:,
1990::
1885::
1606::
1534:,
1530:,
1520::
1438:,
1411::
1388:CI
1373:/
1319:.
1307:.
1284:.
1274:.
1260:.
1256:.
1207:.
1194:^
1158:.
1124:.
1113:^
1099:.
1091:.
1081:32
1079:.
1056:.
1048:.
1036:28
1034:.
1030:.
977:.
966:^
949:.
938:^
912:.
899:^
865:.
850:^
832:.
828:.
815:^
793:.
767:.
741:.
730:^
638:.
494:28
488:29
249:EU
237:US
226:CA
219:S4
213:AU
144:AU
112:US
5719::
5631:/
5600:)
5568:(
5368:)
5362:C
5358:B
5354:A
5352:(
4901:)
4338:)
4336:D
4332:C
4328:B
4324:A
4322:(
4119:)
4117:7
4113:6
4109:5
4105:4
4101:3
4097:2
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497:N
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