1085:
242:
219:
116:
141:
248:
147:
3368:
1147:
inability of traditional bisulfite sequencing to decipher between the two modified bases. In this technique, TET1 is responsible for the oxidation of 5mc allowing it to be read as thymine following treatment with bisulfite. This is not the case for 5hmc as it is glucosylated in the initial step inhibiting its oxidation by TET1.
1146:
The enzyme is also utilized as part of TET-Assisted
Bisulfite Sequencing (TAB-seq) to quantify levels of hydroxymethylation in the genome and to distinguish 5-hydroxymethylcytosine (5hmc) from 5-methylcytosine (5mc) at single base resolution. The technique was developed by Chuan He and rectifies the
1174:
Colon, breast, prostate and liver tumors have significantly reduced levels of TET1 compared to the healthy colon cells and normal epithelial colon cells with downgraded TET1 levels have greater levels of proliferation. Additionally, increasing TET1 expression levels in colon
1195:
Trichostatin A increased levels of TET1 in breast cancer tissues but was a less effective tumor suppressor in patients with low TET1 expression. Breast cancer patients with high TET1 levels had significantly higher survival probabilities than patients with low TET1 levels.
1190:
Breast cancer cell lines with silenced TET1 expression have increased rates of invasion and breast cancers that spread to the lymph nodes are characterized by lower TET1 levels. TET1 levels could be used to detect breast cancer metastasis. A
2397:
Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y (July 2002). "LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)".
1376:
Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y (July 2002). "LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)".
2359:
Morgan AR, Hamilton G, Turic D, Jehu L, Harold D, Abraham R, et al. (September 2008). "Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset
Alzheimer's disease".
2321:
Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR (March 2003). "TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)".
1404:
Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR (March 2003). "TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)".
1203:
lung cancer cells led to reduced metastasis rates and cells. Healthy cells transitioning to cancer cells have decreased levels of TET1 but decreasing TET1 expression does not lead to
255:
154:
1023:, in humans it is encoded by the TET1 gene. Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in
1109:
in mammals. Additionally, downgrading TET1 has decreased levels of 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC) in both cell cultures and mice.
1112:
A site with a 5-hmC base already has increased transcriptional activity, a state termed "functional demethylation". This state is common in post-mitotic
737:
718:
77:
2845:
2738:
2913:
2652:
1200:
3388:
1287:
1269:
241:
2813:
1084:
953:
960:
218:
3087:
2786:
1327:"Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase"
2825:
2771:
1929:"Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1"
1256:
1235:
140:
115:
3243:
1252:
2630:
1192:
1028:
3358:
1305:
1231:
57:
3054:
2903:
1055:
partner of MLL in an 8-year-old patient with t(10;11)(q22;q23) AML and named the protein Ten-Eleven
Translocation 1.
1569:"5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes"
1211:
pathway had decreased invasive potential after reintroducing TET1, likewise downgrading KRAS increased TET1 levels.
254:
153:
2645:
3228:
3344:
3331:
3318:
3305:
3292:
3279:
3266:
3049:
3010:
3000:
2986:
2982:
2972:
2960:
2940:
2923:
2891:
2855:
2755:
2682:
1052:
247:
146:
3238:
3192:
3135:
2673:
1769:"Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients"
1168:
782:
65:
2895:
1870:"TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway"
3140:
2686:
1076:
763:
3034:
2950:
2699:
1040:
1818:"Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation"
3161:
3080:
2830:
2803:
2638:
2421:"Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases"
1184:
129:
3233:
1120:
2945:
2908:
2669:
2518:
2505:
Frauer C, Rottach A, Meilinger D, Bultmann S, Fellinger K, Hasenöder S, et al. (February 2011).
1940:
1580:
1523:
1461:
44:
2278:
Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, et al. (July 2009).
3393:
3197:
2931:
2558:
Langemeijer SM, Aslanyan MG, Jansen JH (December 2009). "TET proteins in malignant hematopoiesis".
1102:
936:
932:
928:
924:
873:
1105:
dependent manner. The conversion of 5-mC to 5-hmC has been proposed as the initial step of active
3130:
2694:
2583:
2385:
2347:
2207:
1909:
1749:
1700:
1430:
89:
2840:
2464:"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain"
1450:"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1"
903:
877:
852:
2227:"Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation"
1868:
Neri F, Dettori D, Incarnato D, Krepelova A, Rapelli S, Maldotti M, et al. (August 2015).
1720:"The combination of Tet1 with Oct4 generates high-quality mouse-induced pluripotent stem cells"
2728:
2618:
2575:
2546:
2493:
2450:
2407:
2377:
2339:
2309:
2256:
2199:
2148:
2117:"TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator"
2097:
2056:
2012:
1968:
1901:
1847:
1798:
1741:
1692:
1657:
1608:
1549:
1487:
1422:
1386:
1358:
1106:
1039:
TET1 was first discovered in a 61-year-old patient with a rare variation of t(10;11)(q22;q23)
1024:
37:
3176:
3171:
3145:
3073:
2608:
2567:
2536:
2526:
2483:
2475:
2440:
2432:
2369:
2331:
2299:
2291:
2246:
2238:
2189:
2179:
2138:
2128:
2087:
2046:
2002:
1958:
1948:
1891:
1881:
1837:
1829:
1788:
1780:
1731:
1684:
1647:
1639:
1598:
1588:
1539:
1531:
1477:
1469:
1414:
1348:
1338:
1160:
1072:
334:
265:
209:
164:
1991:"TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases"
3223:
3207:
3120:
2818:
2166:
Kudo Y, Tateishi K, Yamamoto K, Yamamoto S, Asaoka Y, Ijichi H, et al. (April 2012).
2035:"Hypermethylation of TET1 promoter is a new diagnosic marker for breast cancer metastasis"
309:
85:
2507:"Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1"
1127:
show markedly impaired memory extinction, despite maintaining normal memory acquisition.
2522:
1944:
1675:
Pera MF (December 2013). "Epigenetics, vitamin supplements and cellular reprogramming".
1628:"Tet1 is critical for neuronal activity-regulated gene expression and memory extinction"
1584:
1527:
1465:
1448:
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al. (May 2009).
3372:
3261:
3202:
3044:
3024:
3019:
2661:
2541:
2506:
2488:
2463:
2445:
2420:
2304:
2279:
2251:
2226:
2194:
2168:"Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation"
2167:
2143:
2116:
1963:
1928:
1842:
1817:
1793:
1768:
1652:
1627:
1603:
1568:
1544:
1511:
1482:
1449:
1353:
1326:
1124:
2280:"Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies"
2076:"TET1 partially mediates HDAC inhibitor-induced suppression of breast cancer invasion"
1512:"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine"
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
592:
576:
560:
555:
550:
545:
540:
535:
530:
525:
3382:
3166:
3125:
2597:"TET genes: new players in DNA demethylation and important determinants for stemness"
2184:
1180:
1171:, indicating these diseases may be caused by mistakes in gene expression regulation.
1164:
1156:
1136:
512:
2587:
2389:
2115:
Tsai YP, Chen HF, Chen SY, Cheng WC, Wang HW, Shen ZJ, et al. (December 2014).
1913:
1753:
1704:
1626:
Rudenko A, Dawlaty MM, Seo J, Cheng AW, Meng J, Le T, et al. (September 2013).
1510:
Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, et al. (September 2011).
69:
3115:
2863:
2859:
2351:
2211:
1989:
Hsu CH, Peng KL, Kang ML, Chen YR, Yang YC, Tsai CH, et al. (September 2012).
1434:
327:
106:
2613:
2596:
2531:
2295:
2242:
2051:
2034:
2007:
1990:
1953:
1643:
93:
3339:
3274:
3110:
1292:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1274:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1044:
1020:
3367:
2479:
1573:
Proceedings of the
National Academy of Sciences of the United States of America
410:
2995:
2436:
2133:
1204:
226:
123:
73:
3313:
3287:
2964:
2927:
2871:
2665:
2074:
Lu HG, Zhan W, Yan L, Qin RY, Yan YP, Yang ZJ, et al. (November 2014).
1593:
1535:
1473:
1343:
1140:
1094:
1064:
682:
470:
348:
293:
280:
192:
179:
81:
2622:
2579:
2550:
2497:
2454:
2411:
2381:
2343:
2335:
2313:
2260:
2203:
2152:
2101:
2060:
2016:
1972:
1905:
1851:
1802:
1745:
1696:
1661:
1612:
1553:
1491:
1426:
1418:
1390:
1362:
2571:
2092:
2075:
1816:
Yang H, Liu Y, Bai F, Zhang JY, Ma SH, Liu J, et al. (January 2013).
1179:
cells decreased cell proliferation in both cell cultures and mice through
1000:
995:
2743:
2419:
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, et al. (January 2011).
2373:
1886:
1869:
1718:
Chen J, Gao Y, Huang H, Xu K, Chen X, Jiang Y, et al. (March 2015).
1047:
binding protein (specifically on the CXXC domain) that fuses to the gene
984:
827:
808:
608:
negative regulation of DNA methylation-dependent heterochromatin assembly
1833:
3039:
2362:
American
Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
1896:
1784:
794:
749:
48:, CXXC6, LCX, bA119F7.1, MLL-TET1-MLL, Tet methylcytosine dioxygenase 1
1927:
Liu C, Liu L, Chen X, Shen J, Shan J, Xu Y, et al. (2013-05-09).
1736:
1719:
3326:
3096:
2881:
2876:
2835:
1176:
1113:
968:
704:
561:
DNA-binding transcription factor activity, RNA polymerase II-specific
1688:
3300:
3028:
2763:
2721:
2714:
2709:
2704:
1083:
1048:
667:
663:
2808:
2796:
2791:
2781:
2776:
2759:
2733:
1208:
1098:
61:
3069:
2634:
1068:
3065:
638:
positive regulation of transcription by RNA polymerase II
2033:
Sang Y, Cheng C, Tang XF, Zhang MF, Lv XB (2015-01-01).
317:
1325:
Coulter JB, O'Driscoll CM, Bressler JP (October 2013).
3356:
2462:
Guo JU, Su Y, Zhong C, Ming GL, Song H (April 2011).
1013:
Ten-eleven translocation methylcytosine dioxygenase 1
482:
1767:
Dong E, Gavin DP, Chen Y, Davis J (September 2012).
628:
positive regulation of cell population proliferation
3252:
3216:
3185:
3154:
3103:
3009:
2981:
2959:
2922:
2890:
2854:
2754:
2681:
917:
896:
866:
845:
2595:Mohr F, Döhner K, Buske C, Rawat VP (March 2011).
1248:
1246:
1244:
1227:
1225:
1223:
264:
163:
1051:Another study confirmed that this protein was a
1306:"Entrez Gene: Tet methylcytosine dioxygenase 1"
1567:Mellén M, Ayata P, Heintz N (September 2017).
1253:GRCm38: Ensembl release 89: ENSMUSG00000047146
3081:
2646:
8:
2028:
2026:
1863:
1861:
1984:
1982:
1505:
1503:
1501:
1232:GRCh38: Ensembl release 89: ENSG00000138336
3088:
3074:
3066:
2653:
2639:
2631:
2039:Asian Pacific Journal of Cancer Prevention
678:
598:positive regulation of histone methylation
593:regulation of transcription, DNA-templated
508:
305:
204:
101:
2612:
2540:
2530:
2487:
2444:
2303:
2250:
2193:
2183:
2142:
2132:
2091:
2050:
2006:
1962:
1952:
1895:
1885:
1841:
1792:
1735:
1651:
1602:
1592:
1543:
1481:
1352:
1342:
3363:
1219:
1199:Degradation of TET1 in hypoxia-induced
16:Mammalian protein found in Homo sapiens
18:
269:
230:
225:
168:
127:
122:
7:
2846:24-hydroxycholesterol 7α-hydroxylase
1163:have shown increased levels of TET1
623:inner cell mass cell differentiation
1331:The Journal of Biological Chemistry
1135:TET1 appears to facilitate nuclear
536:methylcytosine dioxygenase activity
2225:Wu BK, Brenner C (December 2014).
914:
893:
863:
842:
818:
799:
773:
754:
728:
709:
648:5-methylcytosine catabolic process
487:
405:
343:
322:
14:
3366:
2185:10.1111/j.1349-7006.2012.02213.x
618:stem cell population maintenance
253:
246:
240:
217:
152:
145:
139:
114:
2826:Cholesterol 7 alpha-hydroxylase
2772:Flavin-containing monooxygenase
1067:the conversion of the modified
1167:and protein expression in the
603:protein O-linked glycosylation
471:More reference expression data
1:
1193:histone deacetylase inhibitor
238:
137:
3389:Genes on human chromosome 10
2614:10.1016/j.exphem.2010.12.004
2532:10.1371/journal.pone.0016627
2296:10.1182/blood-2009-03-210039
2243:10.1016/j.celrep.2014.10.063
2052:10.7314/apjcp.2015.16.3.1197
2008:10.1016/j.celrep.2012.08.030
1954:10.1371/journal.pone.0062828
1644:10.1016/j.neuron.2013.08.003
1041:acute myeloid leukemia (AML)
613:transcription, DNA-templated
3055:Deoxyhypusine monooxygenase
3410:
2480:10.1016/j.cell.2011.03.022
2080:Molecular Medicine Reports
387:retinal pigment epithelium
3244:Michaelis–Menten kinetics
3050:Ecdysone 20-monooxygenase
3001:Stearoyl-CoA desaturase-1
2973:Dopamine beta-hydroxylase
2941:Phenylalanine hydroxylase
2437:10.1016/j.ccr.2010.12.014
2134:10.1186/s13059-014-0513-0
1288:"Mouse PubMed Reference:"
1270:"Human PubMed Reference:"
1207:. Cancer cells using the
999:
994:
990:
983:
967:
948:
921:
900:
889:
870:
849:
838:
825:
821:
806:
802:
793:
780:
776:
761:
757:
748:
735:
731:
716:
712:
703:
688:
681:
677:
661:
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
3136:Diffusion-limited enzyme
1773:Translational Psychiatry
1169:inferior parietal lobule
1119:TET1 may play a role in
961:Chr 10: 62.64 – 62.74 Mb
954:Chr 10: 68.56 – 68.69 Mb
425:Rostral migratory stream
379:tibialis anterior muscle
2601:Experimental Hematology
1594:10.1073/pnas.1708044114
1536:10.1126/science.1210597
1474:10.1126/science.1170116
1344:10.1074/jbc.M113.491365
1093:TET1 produces 5-hmC by
1077:5-hydroxymethylcytosine
653:oxidative demethylation
551:oxidoreductase activity
3035:Squalene monooxygenase
2951:Tryptophan hydroxylase
2700:HIF prolyl-hydroxylase
2336:10.1038/sj.leu.2402834
1419:10.1038/sj.leu.2402834
1088:
643:chromatin organization
457:atrioventricular valve
421:trophoblast giant cell
375:pancreatic ductal cell
271:10 B4|10 32.48 cM
3229:Eadie–Hofstee diagram
3162:Allosteric regulation
2831:Methane monooxygenase
2804:Nitric oxide synthase
2572:10.4161/cc.8.24.10239
2093:10.3892/mmr.2014.2517
1185:WNT signaling pathway
1151:Clinical significance
1087:
1021:TET family of enzymes
1019:) is a member of the
232:Chromosome 10 (mouse)
130:Chromosome 10 (human)
3239:Lineweaver–Burk plot
2946:Tyrosine hydroxylase
2670:steroid hydroxylases
2374:10.1002/ajmg.b.30670
1887:10.1038/onc.2014.356
1183:of promoters of the
1139:of somatic cells to
541:dioxygenase activity
2896:iron–sulfur protein
2523:2011PLoSO...616627F
1945:2013PLoSO...862828L
1834:10.1038/onc.2012.67
1585:2017PNAS..114E7812M
1579:(37): E7812–E7821.
1528:2011Sci...333.1300I
1522:(6047): 1300–1303.
1466:2009Sci...324..930T
1337:(40): 28792–28800.
1103:alpha-ketoglutarate
371:ganglionic eminence
3198:Enzyme superfamily
3131:Enzyme promiscuity
2695:Prolyl hydroxylase
1785:10.1038/tp.2012.86
1089:
783:ENSMUSG00000047146
586:Biological process
570:Cellular component
519:Molecular function
3354:
3353:
3063:
3062:
2729:Lysyl hydroxylase
2566:(24): 4044–4048.
2406:(14): 4075–4080.
1880:(32): 4168–4176.
1737:10.1002/stem.1879
1683:(12): 1412–1413.
1460:(5929): 930–935.
1385:(14): 4075–4080.
1121:memory extinction
1107:DNA demethylation
1025:DNA demethylation
1010:
1009:
1006:
1005:
979:
978:
944:
943:
911:
910:
885:
884:
860:
859:
834:
833:
815:
814:
789:
788:
770:
769:
744:
743:
725:
724:
673:
672:
633:DNA demethylation
546:metal ion binding
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
3401:
3371:
3370:
3362:
3234:Hanes–Woolf plot
3177:Enzyme activator
3172:Enzyme inhibitor
3146:Enzyme catalysis
3090:
3083:
3076:
3067:
2655:
2648:
2641:
2632:
2626:
2616:
2591:
2554:
2544:
2534:
2501:
2491:
2458:
2448:
2415:
2393:
2355:
2317:
2307:
2265:
2264:
2254:
2237:(5): 1827–1840.
2222:
2216:
2215:
2197:
2187:
2163:
2157:
2156:
2146:
2136:
2112:
2106:
2105:
2095:
2086:(5): 2595–2600.
2071:
2065:
2064:
2054:
2045:(3): 1197–1200.
2030:
2021:
2020:
2010:
1986:
1977:
1976:
1966:
1956:
1924:
1918:
1917:
1899:
1889:
1865:
1856:
1855:
1845:
1813:
1807:
1806:
1796:
1764:
1758:
1757:
1739:
1715:
1709:
1708:
1672:
1666:
1665:
1655:
1638:(6): 1109–1122.
1623:
1617:
1616:
1606:
1596:
1564:
1558:
1557:
1547:
1507:
1496:
1495:
1485:
1445:
1439:
1438:
1401:
1395:
1394:
1373:
1367:
1366:
1356:
1346:
1322:
1316:
1315:
1313:
1312:
1302:
1296:
1295:
1284:
1278:
1277:
1266:
1260:
1250:
1239:
1229:
1161:bipolar disorder
1073:5-methylcytosine
992:
991:
963:
956:
939:
915:
906:
894:
890:RefSeq (protein)
880:
864:
855:
843:
819:
800:
774:
755:
729:
710:
679:
531:zinc ion binding
526:iron ion binding
509:
488:
473:
449:primitive streak
441:ejaculatory duct
433:genital tubercle
413:
411:Top expressed in
406:
363:ventricular zone
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:TET1 - orthologs
47:
40:
19:
3409:
3408:
3404:
3403:
3402:
3400:
3399:
3398:
3379:
3378:
3377:
3365:
3357:
3355:
3350:
3262:Oxidoreductases
3248:
3224:Enzyme kinetics
3212:
3208:List of enzymes
3181:
3150:
3121:Catalytic triad
3099:
3094:
3064:
3059:
3013:- miscellaneous
3005:
2977:
2955:
2918:
2886:
2850:
2841:14α-demethylase
2750:
2677:
2662:Oxidoreductases
2659:
2629:
2594:
2557:
2504:
2461:
2418:
2400:Cancer Research
2396:
2358:
2320:
2277:
2273:
2271:Further reading
2268:
2224:
2223:
2219:
2165:
2164:
2160:
2114:
2113:
2109:
2073:
2072:
2068:
2032:
2031:
2024:
1988:
1987:
1980:
1926:
1925:
1921:
1867:
1866:
1859:
1815:
1814:
1810:
1766:
1765:
1761:
1717:
1716:
1712:
1689:10.1038/ng.2834
1677:Nature Genetics
1674:
1673:
1669:
1625:
1624:
1620:
1566:
1565:
1561:
1509:
1508:
1499:
1447:
1446:
1442:
1403:
1402:
1398:
1379:Cancer Research
1375:
1374:
1370:
1324:
1323:
1319:
1310:
1308:
1304:
1303:
1299:
1286:
1285:
1281:
1268:
1267:
1263:
1251:
1242:
1230:
1221:
1217:
1153:
1133:
1061:
1037:
1029:gene regulation
1001:View/Edit Mouse
996:View/Edit Human
959:
952:
949:Location (UCSC)
935:
931:
927:
923:
902:
876:
872:
851:
764:ENSG00000138336
657:
581:
565:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
367:Achilles tendon
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
3407:
3405:
3397:
3396:
3391:
3381:
3380:
3376:
3375:
3352:
3351:
3349:
3348:
3335:
3322:
3309:
3296:
3283:
3270:
3256:
3254:
3250:
3249:
3247:
3246:
3241:
3236:
3231:
3226:
3220:
3218:
3214:
3213:
3211:
3210:
3205:
3200:
3195:
3189:
3187:
3186:Classification
3183:
3182:
3180:
3179:
3174:
3169:
3164:
3158:
3156:
3152:
3151:
3149:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3107:
3105:
3101:
3100:
3095:
3093:
3092:
3085:
3078:
3070:
3061:
3060:
3058:
3057:
3052:
3047:
3042:
3037:
3032:
3025:Heme oxygenase
3022:
3020:Cyclooxygenase
3016:
3014:
3007:
3006:
3004:
3003:
2998:
2992:
2990:
2979:
2978:
2976:
2975:
2969:
2967:
2957:
2956:
2954:
2953:
2948:
2943:
2937:
2935:
2920:
2919:
2917:
2916:
2911:
2906:
2900:
2898:
2888:
2887:
2885:
2884:
2879:
2874:
2868:
2866:
2852:
2851:
2849:
2848:
2843:
2838:
2833:
2828:
2823:
2822:
2821:
2816:
2811:
2801:
2800:
2799:
2794:
2789:
2784:
2779:
2768:
2766:
2752:
2751:
2749:
2748:
2747:
2746:
2741:
2731:
2726:
2725:
2724:
2719:
2718:
2717:
2712:
2707:
2691:
2689:
2687:2-oxoglutarate
2679:
2678:
2660:
2658:
2657:
2650:
2643:
2635:
2628:
2627:
2607:(3): 272–281.
2592:
2555:
2502:
2474:(3): 423–434.
2459:
2416:
2394:
2368:(6): 727–731.
2356:
2330:(3): 637–641.
2318:
2290:(1): 144–147.
2274:
2272:
2269:
2267:
2266:
2217:
2178:(4): 670–676.
2172:Cancer Science
2158:
2121:Genome Biology
2107:
2066:
2022:
2001:(3): 568–579.
1978:
1919:
1857:
1828:(5): 663–669.
1808:
1759:
1730:(3): 686–698.
1710:
1667:
1618:
1559:
1497:
1440:
1413:(3): 637–641.
1396:
1368:
1317:
1297:
1279:
1261:
1240:
1218:
1216:
1213:
1155:Patients with
1152:
1149:
1132:
1129:
1097:of 5-mC in an
1091:
1090:
1060:
1057:
1036:
1033:
1027:and therefore
1008:
1007:
1004:
1003:
998:
988:
987:
981:
980:
977:
976:
974:
972:
965:
964:
957:
950:
946:
945:
942:
941:
919:
918:
912:
909:
908:
898:
897:
891:
887:
886:
883:
882:
868:
867:
861:
858:
857:
847:
846:
840:
836:
835:
832:
831:
823:
822:
816:
813:
812:
804:
803:
797:
791:
790:
787:
786:
778:
777:
771:
768:
767:
759:
758:
752:
746:
745:
742:
741:
733:
732:
726:
723:
722:
714:
713:
707:
701:
700:
695:
690:
686:
685:
675:
674:
671:
670:
659:
658:
656:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
589:
587:
583:
582:
580:
579:
573:
571:
567:
566:
564:
563:
558:
553:
548:
543:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
429:tail of embryo
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
391:deltoid muscle
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3406:
3395:
3392:
3390:
3387:
3386:
3384:
3374:
3369:
3364:
3360:
3346:
3342:
3341:
3336:
3333:
3329:
3328:
3323:
3320:
3316:
3315:
3310:
3307:
3303:
3302:
3297:
3294:
3290:
3289:
3284:
3281:
3277:
3276:
3271:
3268:
3264:
3263:
3258:
3257:
3255:
3251:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3221:
3219:
3215:
3209:
3206:
3204:
3203:Enzyme family
3201:
3199:
3196:
3194:
3191:
3190:
3188:
3184:
3178:
3175:
3173:
3170:
3168:
3167:Cooperativity
3165:
3163:
3160:
3159:
3157:
3153:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3126:Oxyanion hole
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3108:
3106:
3102:
3098:
3091:
3086:
3084:
3079:
3077:
3072:
3071:
3068:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3030:
3026:
3023:
3021:
3018:
3017:
3015:
3012:
3008:
3002:
2999:
2997:
2994:
2993:
2991:
2988:
2984:
2980:
2974:
2971:
2970:
2968:
2966:
2962:
2958:
2952:
2949:
2947:
2944:
2942:
2939:
2938:
2936:
2933:
2932:BH4 dependent
2929:
2925:
2921:
2915:
2912:
2910:
2907:
2905:
2902:
2901:
2899:
2897:
2893:
2889:
2883:
2880:
2878:
2875:
2873:
2870:
2869:
2867:
2865:
2861:
2857:
2853:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2827:
2824:
2820:
2817:
2815:
2812:
2810:
2807:
2806:
2805:
2802:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2774:
2773:
2770:
2769:
2767:
2765:
2761:
2757:
2753:
2745:
2742:
2740:
2737:
2736:
2735:
2732:
2730:
2727:
2723:
2720:
2716:
2713:
2711:
2708:
2706:
2703:
2702:
2701:
2698:
2697:
2696:
2693:
2692:
2690:
2688:
2684:
2680:
2675:
2671:
2667:
2663:
2656:
2651:
2649:
2644:
2642:
2637:
2636:
2633:
2624:
2620:
2615:
2610:
2606:
2602:
2598:
2593:
2589:
2585:
2581:
2577:
2573:
2569:
2565:
2561:
2556:
2552:
2548:
2543:
2538:
2533:
2528:
2524:
2520:
2517:(2): e16627.
2516:
2512:
2508:
2503:
2499:
2495:
2490:
2485:
2481:
2477:
2473:
2469:
2465:
2460:
2456:
2452:
2447:
2442:
2438:
2434:
2430:
2426:
2422:
2417:
2413:
2409:
2405:
2401:
2395:
2391:
2387:
2383:
2379:
2375:
2371:
2367:
2363:
2357:
2353:
2349:
2345:
2341:
2337:
2333:
2329:
2325:
2319:
2315:
2311:
2306:
2301:
2297:
2293:
2289:
2285:
2281:
2276:
2275:
2270:
2262:
2258:
2253:
2248:
2244:
2240:
2236:
2232:
2228:
2221:
2218:
2213:
2209:
2205:
2201:
2196:
2191:
2186:
2181:
2177:
2173:
2169:
2162:
2159:
2154:
2150:
2145:
2140:
2135:
2130:
2126:
2122:
2118:
2111:
2108:
2103:
2099:
2094:
2089:
2085:
2081:
2077:
2070:
2067:
2062:
2058:
2053:
2048:
2044:
2040:
2036:
2029:
2027:
2023:
2018:
2014:
2009:
2004:
2000:
1996:
1992:
1985:
1983:
1979:
1974:
1970:
1965:
1960:
1955:
1950:
1946:
1942:
1939:(5): e62828.
1938:
1934:
1930:
1923:
1920:
1915:
1911:
1907:
1903:
1898:
1893:
1888:
1883:
1879:
1875:
1871:
1864:
1862:
1858:
1853:
1849:
1844:
1839:
1835:
1831:
1827:
1823:
1819:
1812:
1809:
1804:
1800:
1795:
1790:
1786:
1782:
1778:
1774:
1770:
1763:
1760:
1755:
1751:
1747:
1743:
1738:
1733:
1729:
1725:
1721:
1714:
1711:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1671:
1668:
1663:
1659:
1654:
1649:
1645:
1641:
1637:
1633:
1629:
1622:
1619:
1614:
1610:
1605:
1600:
1595:
1590:
1586:
1582:
1578:
1574:
1570:
1563:
1560:
1555:
1551:
1546:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1513:
1506:
1504:
1502:
1498:
1493:
1489:
1484:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1444:
1441:
1436:
1432:
1428:
1424:
1420:
1416:
1412:
1408:
1400:
1397:
1392:
1388:
1384:
1380:
1372:
1369:
1364:
1360:
1355:
1350:
1345:
1340:
1336:
1332:
1328:
1321:
1318:
1307:
1301:
1298:
1293:
1289:
1283:
1280:
1275:
1271:
1265:
1262:
1258:
1254:
1249:
1247:
1245:
1241:
1237:
1233:
1228:
1226:
1224:
1220:
1214:
1212:
1210:
1206:
1202:
1197:
1194:
1188:
1186:
1182:
1181:demethylation
1178:
1172:
1170:
1166:
1162:
1158:
1157:schizophrenia
1150:
1148:
1144:
1142:
1138:
1137:reprogramming
1130:
1128:
1126:
1125:knockout mice
1122:
1117:
1115:
1110:
1108:
1104:
1100:
1096:
1086:
1082:
1081:
1080:
1078:
1074:
1070:
1066:
1058:
1056:
1054:
1053:translocation
1050:
1046:
1042:
1034:
1032:
1030:
1026:
1022:
1018:
1014:
1002:
997:
993:
989:
986:
982:
975:
973:
970:
966:
962:
958:
955:
951:
947:
940:
938:
934:
930:
926:
920:
916:
913:
907:
905:
899:
895:
892:
888:
881:
879:
875:
869:
865:
862:
856:
854:
848:
844:
841:
839:RefSeq (mRNA)
837:
830:
829:
824:
820:
817:
811:
810:
805:
801:
798:
796:
792:
785:
784:
779:
775:
772:
766:
765:
760:
756:
753:
751:
747:
740:
739:
734:
730:
727:
721:
720:
715:
711:
708:
706:
702:
699:
696:
694:
691:
687:
684:
680:
676:
669:
665:
660:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
590:
588:
585:
584:
578:
575:
574:
572:
569:
568:
562:
559:
557:
554:
552:
549:
547:
544:
542:
539:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
3340:Translocases
3337:
3324:
3311:
3298:
3285:
3275:Transferases
3272:
3259:
3116:Binding site
2864:flavoprotein
2668:, including
2666:dioxygenases
2604:
2600:
2563:
2559:
2514:
2510:
2471:
2467:
2431:(1): 17–30.
2428:
2424:
2403:
2399:
2365:
2361:
2327:
2323:
2287:
2283:
2234:
2231:Cell Reports
2230:
2220:
2175:
2171:
2161:
2124:
2120:
2110:
2083:
2079:
2069:
2042:
2038:
1998:
1995:Cell Reports
1994:
1936:
1932:
1922:
1877:
1873:
1825:
1821:
1811:
1776:
1772:
1762:
1727:
1723:
1713:
1680:
1676:
1670:
1635:
1631:
1621:
1576:
1572:
1562:
1519:
1515:
1457:
1453:
1443:
1410:
1406:
1399:
1382:
1378:
1371:
1334:
1330:
1320:
1309:. Retrieved
1300:
1291:
1282:
1273:
1264:
1198:
1189:
1173:
1154:
1145:
1134:
1131:Applications
1118:
1111:
1092:
1062:
1038:
1016:
1012:
1011:
937:NP_001393312
933:NP_001393311
929:NP_001393310
925:NP_001240786
922:
901:
874:NM_001253857
871:
850:
826:
807:
781:
762:
736:
717:
697:
692:
333:
326:
53:External IDs
3111:Active site
2425:Cancer Cell
2127:(12): 513.
1897:2318/150019
1779:(9): e159.
1045:zinc-finger
556:DNA binding
395:sural nerve
292:62,744,775
279:62,640,349
191:68,694,487
178:68,560,337
31:Identifiers
3394:EC 1.14.11
3383:Categories
3314:Isomerases
3288:Hydrolases
3155:Regulation
2996:Tyrosinase
2963:: reduced
2926:: reduced
2894:: reduced
2858:: reduced
2560:Cell Cycle
1724:Stem Cells
1311:2012-07-26
1259:, May 2017
1238:, May 2017
1215:References
1205:malignancy
1075:(5-mC) to
437:blastocyst
337:(ortholog)
74:HomoloGene
3193:EC number
2965:ascorbate
2928:pteridine
1141:iPS cells
1095:oxidation
1079:(5-hmC).
1065:catalyzes
1035:Discovery
904:NP_085128
878:NM_027384
853:NM_030625
683:Orthologs
82:GeneCards
3217:Kinetics
3141:Cofactor
3104:Activity
2623:21168469
2588:27430810
2580:19923888
2551:21311766
2511:PLOS ONE
2498:21496894
2455:21251613
2412:12124344
2390:13916214
2382:18163421
2344:12646957
2324:Leukemia
2314:19420352
2261:25466250
2204:22320381
2153:25517638
2102:25175940
2061:25735355
2017:22999938
1973:23671639
1933:PLOS ONE
1914:22017396
1906:25362856
1874:Oncogene
1852:22391558
1822:Oncogene
1803:22948384
1754:42714024
1746:25331067
1705:11597504
1697:24270443
1662:24050401
1613:28847947
1554:21778364
1492:19372391
1427:12646957
1407:Leukemia
1391:12124344
1363:23940045
1255:–
1234:–
1059:Function
985:Wikidata
662:Sources:
383:testicle
3373:Biology
3327:Ligases
3097:Enzymes
3011:1.14.99
2989:: other
2983:1.14.18
2961:1.14.17
2924:1.14.16
2892:1.14.15
2856:1.14.14
2756:1.14.13
2683:1.14.11
2542:3032784
2519:Bibcode
2489:3088758
2446:3229304
2352:1202064
2305:2710942
2252:4268240
2212:5823834
2195:7659252
2144:4253621
1964:3650038
1941:Bibcode
1843:3897214
1794:3565208
1653:4543319
1604:5604027
1581:Bibcode
1545:3495246
1524:Bibcode
1516:Science
1483:2715015
1462:Bibcode
1454:Science
1435:1202064
1354:3789975
1257:Ensembl
1236:Ensembl
1123:. TET1-
1114:neurons
795:UniProt
750:Ensembl
689:Species
668:QuickGO
577:nucleus
312:pattern
170:10q21.3
70:1098693
38:Aliases
3359:Portal
3301:Lyases
2860:flavin
2739:ALKBH1
2621:
2586:
2578:
2549:
2539:
2496:
2486:
2453:
2443:
2410:
2388:
2380:
2350:
2342:
2312:
2302:
2259:
2249:
2210:
2202:
2192:
2151:
2141:
2100:
2059:
2015:
1971:
1961:
1912:
1904:
1850:
1840:
1801:
1791:
1752:
1744:
1703:
1695:
1660:
1650:
1632:Neuron
1611:
1601:
1552:
1542:
1490:
1480:
1433:
1425:
1389:
1361:
1351:
1177:cancer
971:search
969:PubMed
828:Q3URK3
809:Q8NFU7
705:Entrez
483:BioGPS
453:embryo
445:morula
62:607790
3253:Types
3029:HMOX1
2764:NADPH
2722:P4HTM
2715:EGLN3
2710:EGLN2
2705:EGLN1
2676:1.14)
2584:S2CID
2386:S2CID
2348:S2CID
2284:Blood
2208:S2CID
1910:S2CID
1750:S2CID
1701:S2CID
1431:S2CID
1071:base
1063:TET1
1043:as a
738:52463
719:80312
698:Mouse
693:Human
664:Amigo
359:gonad
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:12735
3345:list
3338:EC7
3332:list
3325:EC6
3319:list
3312:EC5
3306:list
3299:EC4
3293:list
3286:EC3
3280:list
3273:EC2
3267:list
3260:EC1
3045:21A2
3040:17A1
2914:11A1
2909:11B2
2904:11B1
2872:19A1
2819:NOS3
2814:NOS2
2809:NOS1
2797:FMO5
2792:FMO4
2787:FMO3
2782:FMO2
2777:FMO1
2760:NADH
2734:AlkB
2619:PMID
2576:PMID
2547:PMID
2494:PMID
2468:Cell
2451:PMID
2408:PMID
2378:PMID
2366:147B
2340:PMID
2310:PMID
2257:PMID
2200:PMID
2149:PMID
2098:PMID
2057:PMID
2013:PMID
1969:PMID
1902:PMID
1848:PMID
1799:PMID
1742:PMID
1693:PMID
1658:PMID
1609:PMID
1550:PMID
1488:PMID
1423:PMID
1387:PMID
1359:PMID
1209:KRAS
1165:mRNA
1101:and
1099:iron
1049:MLL.
1017:TET1
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:TET1
58:OMIM
45:TET1
22:TET1
2882:2E1
2877:2D6
2862:or
2836:3A4
2762:or
2744:FTO
2609:doi
2568:doi
2537:PMC
2527:doi
2484:PMC
2476:doi
2472:145
2441:PMC
2433:doi
2370:doi
2332:doi
2300:PMC
2292:doi
2288:114
2247:PMC
2239:doi
2190:PMC
2180:doi
2176:103
2139:PMC
2129:doi
2088:doi
2047:doi
2003:doi
1959:PMC
1949:doi
1892:hdl
1882:doi
1838:PMC
1830:doi
1789:PMC
1781:doi
1732:doi
1685:doi
1648:PMC
1640:doi
1599:PMC
1589:doi
1577:114
1540:PMC
1532:doi
1520:333
1478:PMC
1470:doi
1458:324
1415:doi
1349:PMC
1339:doi
1335:288
1201:EMT
1159:or
1069:DNA
491:n/a
288:End
187:End
90:OMA
66:MGI
3385::
2987:19
2758::
2685::
2674:EC
2664::
2617:.
2605:39
2603:.
2599:.
2582:.
2574:.
2562:.
2545:.
2535:.
2525:.
2513:.
2509:.
2492:.
2482:.
2470:.
2466:.
2449:.
2439:.
2429:19
2427:.
2423:.
2404:62
2402:.
2384:.
2376:.
2364:.
2346:.
2338:.
2328:17
2326:.
2308:.
2298:.
2286:.
2282:.
2255:.
2245:.
2233:.
2229:.
2206:.
2198:.
2188:.
2174:.
2170:.
2147:.
2137:.
2125:15
2123:.
2119:.
2096:.
2084:10
2082:.
2078:.
2055:.
2043:16
2041:.
2037:.
2025:^
2011:.
1997:.
1993:.
1981:^
1967:.
1957:.
1947:.
1935:.
1931:.
1908:.
1900:.
1890:.
1878:34
1876:.
1872:.
1860:^
1846:.
1836:.
1826:32
1824:.
1820:.
1797:.
1787:.
1775:.
1771:.
1748:.
1740:.
1728:33
1726:.
1722:.
1699:.
1691:.
1681:45
1679:.
1656:.
1646:.
1636:79
1634:.
1630:.
1607:.
1597:.
1587:.
1575:.
1571:.
1548:.
1538:.
1530:.
1518:.
1514:.
1500:^
1486:.
1476:.
1468:.
1456:.
1452:.
1429:.
1421:.
1411:17
1409:.
1383:62
1381:.
1357:.
1347:.
1333:.
1329:.
1290:.
1272:.
1243:^
1222:^
1187:.
1143:.
1116:.
1031:.
666:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
3361::
3347:)
3343:(
3334:)
3330:(
3321:)
3317:(
3308:)
3304:(
3295:)
3291:(
3282:)
3278:(
3269:)
3265:(
3089:e
3082:t
3075:v
3031:)
3027:(
2985:-
2934:)
2930:(
2672:(
2654:e
2647:t
2640:v
2625:.
2611::
2590:.
2570::
2564:8
2553:.
2529::
2521::
2515:6
2500:.
2478::
2457:.
2435::
2414:.
2392:.
2372::
2354:.
2334::
2316:.
2294::
2263:.
2241::
2235:9
2214:.
2182::
2155:.
2131::
2104:.
2090::
2063:.
2049::
2019:.
2005::
1999:2
1975:.
1951::
1943::
1937:8
1916:.
1894::
1884::
1854:.
1832::
1805:.
1783::
1777:2
1756:.
1734::
1707:.
1687::
1664:.
1642::
1615:.
1591::
1583::
1556:.
1534::
1526::
1494:.
1472::
1464::
1437:.
1417::
1393:.
1365:.
1341::
1314:.
1294:.
1276:.
1015:(
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
