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Theca of follicle

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during oocyte maturation. Theca cells are only correlated with developing ovarian follicles. They are the leading cause of endocrine-based infertility, as either hyperactivity or hypoactivity of the theca cells can lead to fertility problems.
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Hyperactivity of theca cells causes hyperandrogenism, and hypoactivity leads to a lack of estrogen. Granulosa cell tumors, while rare (less than 5% of ovarian cancers), may both granulosa cells and theca cells.
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Theca cells are a group of endocrine cells in the ovary made up of connective tissue surrounding the follicle. They have many diverse functions, including promoting
798: 555: 500: 827: 821: 262: 601: 547: 492: 282:. In early stages of the ovarian cycle, the developing follicle acquires a layer of connective tissue and associated blood vessels. This covering is called the 199: 1798: 708:"Thecoma of the ovary: a report of 70 cases emphasizing aspects of its histopathology different from those often portrayed and its differential diagnosis" 1944: 136:
during development by the establishment of a vascular system, providing nutrients, and providing structure and support to the follicle as it matures.
1949: 882: 844: 833: 209:(GPCRs) bind to LH in the bloodstream, and the signal is transduced to the interior of theca cells through the action of the second messenger 770: 577: 1722: 171:. FSH induces the granulosa cells to synthesize aromatase, an enzyme that converts the androgens made by the theca interna into estradiol. 875: 1201: 399: 523: 468: 1634: 1279: 353: 195: 179: 1651: 1727: 1584: 1354: 1166: 1128: 1023: 365: 191: 394:. Vol. 1: Section V:Sexual Development and Function (14th. ed.). Elsevier Health Sciences. pp. 586–587. 1803: 1707: 992: 347: 1455: 1028: 898: 605: 206: 1845: 1793: 1732: 1697: 1564: 1747: 1712: 1557: 1349: 1133: 657:
Kottarathil, Vijaykumar Dehannathparambil; Antony, Michelle Aline; Nair, Indu R.; Pavithran, Keechilat (2013).
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and recruitment of a single follicle during ovulation. Theca cells and granulosa cells together form the
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Melmed, Shlomo; Koenig, Ronald; Rosen, Clifford; Auchus, Richard; Goldfine, Allison (2020).
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The anterior pituitary complex and hypophyseal portal system, where FSH and LH are released.
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are benign proliferations of theca cells that may present with hormonal dysfunction.
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fluid (a mixture of hormones, enzymes, and anticoagulants) to nourish the maturing
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Conversion of testosterone to estradiol through the action of aromatase.
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In tertiary follicles, the single-layered theca differentiates into a
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Over a period of months, the granulosa cells and thecal cells secrete
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is composed of dense connective tissue and larger blood vessels.
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contains glandular cells and many small blood vessels, while the
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progresses, granulosa cells proliferate to form the multilayered
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The International Journal of Biochemistry & Cell Biology
659:"Recent Advances in Granulosa Cell Tumor Ovary: A Review" 818: â€“ Histology Learning System at Boston University 1891: 1825: 1779: 1610: 1491: 1482: 1473: 1424: 1403: 1378: 1340: 1295: 1230: 1221: 1182: 1152: 1109: 1064: 1016: 932: 923: 914: 905: 857:
Anatomy Atlases – Microscopic Anatomy, plate 13.249
420:"Theca: the forgotten cell of the ovarian follicle" 36: 31: 26: 21: 249:Theca cells (along with granulosa cells) form the 217:(PKA). Theca cells are then stimulated to produce 147:Theca cells are responsible for the production of 622:Magoffin, Denis A. (2005). "Ovarian theca cell". 518:(13th ed.). Philadelphia, PA. p. 1044. 514:Hall, John E. (John Edward), 1946- (2015-05-20). 463:(13th ed.). Philadelphia, PA. p. 1042. 459:Hall, John E. (John Edward), 1946- (2015-05-20). 828:Anatomy photo: Reproductive/mammal/ovary5/ovary6 822:Anatomy photo: Reproductive/mammal/ovary2/ovary5 761:Jones, Richard E. (Richard Evan), 1940- (2006). 706:Burandt, Eike; Young, Robert H. (August 2014). 155:, also called E2, by supplying the neighboring 617: 615: 516:Guyton and Hall textbook of medical physiology 461:Guyton and Hall textbook of medical physiology 413: 411: 883: 124:Theca cells are responsible for synthesizing 8: 793:: CS1 maint: multiple names: authors list ( 278:surrounded by a layer of closely associated 167:can be used as a substrate for this type of 550:) CS1 maint: multiple names: authors list ( 495:) CS1 maint: multiple names: authors list ( 266:A depiction of the ovarian cycle in animals 81:The theca are divided into two layers, the 1488: 1479: 1227: 929: 920: 911: 890: 876: 868: 797:) CS1 maint: numeric names: authors list ( 712:The American Journal of Surgical Pathology 600:: CS1 maint: location missing publisher ( 554:) CS1 maint: numeric names: authors list ( 546:: CS1 maint: location missing publisher ( 499:) CS1 maint: numeric names: authors list ( 491:: CS1 maint: location missing publisher ( 682: 435: 261: 128:, providing signal transduction between 378: 151:, and indirectly the production of 17β 786: 593: 539: 484: 418:Young, J. M.; McNeilly, A. S. (2010). 74:. They appear as the follicles become 53: 18: 7: 1660:Infra-corporeal residual spongy part 663:Indian Journal of Surgical Oncology 392:Williams Textbook of Endocrinology 205:Within the ovaries, transmembrane 14: 1945:Mammal female reproductive system 163:that with the help of the enzyme 1950:Steroid hormone secreting cells 1656:Trabeculae of corpora cavernosa 354:dehydroepiandrosterone sulfate 180:Gonadotropin releasing hormone 16:Layer of the ovarian follicles 1: 724:10.1097/PAS.0000000000000252 636:10.1016/j.biocel.2005.01.016 366:follicle-stimulating hormone 270:In human adult females, the 192:follicle-stimulating hormone 1804:Internal urethral sphincter 348:polycystic ovarian syndrome 207:G-protein coupled receptors 1966: 899:Female reproductive system 763:Human reproductive biology 190:are stimulated to produce 1809:External urethral orifice 1799:External sphincter muscle 1794:Internal urethral orifice 1603:Vestibular gland openings 1565:Posterior labial arteries 816:Histology image: 14805loa 675:10.1007/s13193-012-0201-z 48: 1723:Superficial dorsal veins 1713:Internal pudendal artery 274:is composed of a single 70:comprise a layer of the 1876:Uterine venous plexuses 1738:Internal pudendal veins 1536:Posterior labial nerves 225:fashion to neighboring 1570:Posterior labial veins 1541:Anterior labial nerves 1370:Pubocervical ligaments 845:UIUC Histology Subject 834:UIUC Histology Subject 288:As development of the 267: 144: 121: 50:Anatomical terminology 1881:Vaginal venous plexus 1365:Uterosacral ligaments 604:) CS1 maint: others ( 265: 221:, which is sent in a 142: 119: 1924:Uterotubal junctions 1526:Posterior commissure 1391:Urogenital diaphragm 1280:Supravaginal portion 1202:Vesicular appendages 1167:Suspensory ligaments 1111:Fallopian tubes 863:Slide at trinity.edu 294:membrana granulosum. 213:and third messenger 1919:Vesicouterine pouch 1670:Commissure of bulbs 1635:Suspensory ligament 1521:Anterior commissure 1144:Intramural segments 1024:Germinal epithelium 1008:Perivitelline space 437:10.1530/REP-10-0094 360:luteinizing hormone 272:primordial follicle 196:luteinizing hormone 76:secondary follicles 1914:Rectouterine pouch 1640:Fundiform ligament 1456:Support structures 1411:Bartholin's glands 1360:Cardinal ligaments 1172:Pampiniform plexus 1003:Membrana granulosa 570:Medical physiology 290:secondary follicle 268: 229:for conversion to 184:anterior pituitary 145: 122: 112:Androgen synthesis 1932: 1931: 1821: 1820: 1817: 1816: 1728:Deep dorsal veins 1708:Arteries of bulbs 1652:Corpora cavernosa 1575:Interlabial sulci 1516:Labiocrural folds 1469: 1468: 1404:Vestibular glands 1399: 1398: 1217: 1216: 1184:Wolffian vestiges 1162:Ovarian ligaments 1105: 1104: 981:Follicular antrum 772:978-0-12-088465-0 579:978-1-4557-3328-6 175:Signaling cascade 72:ovarian follicles 64: 63: 59: 22:Theca of follicle 1957: 1836:Ovarian arteries 1769:Tunica albuginea 1531:Dartos muliebris 1489: 1480: 1228: 1039:Cumulus oophorus 1029:Tunica albuginea 986:Follicular fluid 930: 921: 912: 892: 885: 878: 869: 803: 802: 792: 784: 758: 752: 751: 718:(8): 1023–1032. 703: 697: 696: 686: 654: 648: 647: 619: 610: 609: 599: 591: 566: 560: 559: 545: 537: 511: 505: 504: 490: 482: 456: 450: 449: 439: 415: 406: 405: 383: 258:Folliculogenesis 215:protein kinase A 98:folliculogenesis 56:edit on Wikidata 19: 1965: 1964: 1960: 1959: 1958: 1956: 1955: 1954: 1935: 1934: 1933: 1928: 1909:Perineal sponge 1904:Urethral sponge 1887: 1856:Spiral arteries 1813: 1775: 1698:Dorsal arteries 1675:Pars intermedia 1606: 1592:Vaginal orifice 1465: 1420: 1395: 1374: 1355:Broad ligaments 1350:Round ligaments 1336: 1291: 1213: 1192:Gartner's ducts 1178: 1148: 1101: 1060: 1012: 901: 896: 812: 807: 806: 785: 773: 760: 759: 755: 705: 704: 700: 656: 655: 651: 621: 620: 613: 592: 580: 568: 567: 563: 538: 526: 513: 512: 508: 483: 471: 458: 457: 453: 417: 416: 409: 402: 385: 384: 380: 375: 329: 280:granulosa cells 260: 239: 227:granulosa cells 177: 161:androstenedione 157:granulosa cells 149:androstenedione 130:granulosa cells 114: 68:theca folliculi 60: 43:theca folliculi 17: 12: 11: 5: 1963: 1961: 1953: 1952: 1947: 1937: 1936: 1930: 1929: 1927: 1926: 1921: 1916: 1911: 1906: 1901: 1895: 1893: 1889: 1888: 1886: 1885: 1884: 1883: 1878: 1873: 1868: 1860: 1859: 1858: 1853: 1851:Vaginal artery 1848: 1846:Arcuate artery 1843: 1841:Uterine artery 1838: 1829: 1827: 1823: 1822: 1819: 1818: 1815: 1814: 1812: 1811: 1806: 1801: 1796: 1791: 1789:Urethral crest 1785: 1783: 1777: 1776: 1774: 1773: 1770: 1767: 1762: 1757: 1756: 1755: 1753:Pudendal nerve 1750: 1742: 1741: 1740: 1735: 1733:Veins of bulbs 1730: 1725: 1717: 1716: 1715: 1710: 1705: 1700: 1692: 1691: 1690: 1685: 1677: 1672: 1667: 1666: 1665: 1662: 1657: 1654: 1644: 1643: 1642: 1637: 1632: 1627: 1616: 1614: 1608: 1607: 1605: 1604: 1601: 1600: 1599: 1589: 1588: 1587: 1577: 1572: 1567: 1562: 1561: 1560: 1550: 1549: 1548: 1546:Perineal nerve 1543: 1538: 1533: 1528: 1523: 1518: 1513: 1511:Pudendal cleft 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44: 41: 39: 35: 30: 25: 20: 1871:Uterine vein 1826:Blood supply 1553:Labia minora 1506:Labia majora 1056:Retia ovarii 1033: 963: 941: 855: 847: 836: 762: 756: 715: 711: 701: 669:(1): 37–47. 666: 662: 652: 627: 623: 569: 564: 515: 509: 460: 454: 427: 424:Reproduction 423: 391: 381: 320: 316: 312: 308: 306: 293: 287: 283: 269: 248: 240: 219:testosterone 204: 188:Gonadotrophs 178: 146: 123: 95: 88: 82: 80: 67: 65: 42: 1327:Parametrium 1320:Perimetrium 1310:Endometrium 1275:External os 1270:Internal os 1129:Infundibula 32:Identifiers 1939:Categories 1501:Mons pubis 1461:Epithelium 1332:Epithelium 1315:Myometrium 1209:Paroophora 373:References 194:(FSH) and 1832:Arteries 1694:Arteries 1580:Vestibule 1342:Ligaments 1197:Epoophora 1154:Ligaments 1066:Oogenesis 934:Follicles 852:- externa 841:- interna 789:cite book 732:1532-0979 596:cite book 588:951680737 542:cite book 534:900869748 487:cite book 479:900869748 237:Disorders 231:estradiol 223:paracrine 169:estradiol 165:aromatase 153:estradiol 126:androgens 1688:Frenulum 1612:Clitoris 1558:Frenulum 1475:External 1449:Fornices 1134:Fimbriae 1124:Ampullae 1074:Oogonium 957:Albicans 907:Internal 781:61351645 748:10739300 740:25025365 693:24426698 644:15833266 446:20628033 327:See also 244:Thecomas 200:HPG axis 87:and the 1781:Urethra 1744:Nerves 1379:General 1255:Isthmus 1231:Regions 1051:Medulla 974:Interna 969:Externa 925:Ovaries 684:3578540 356:(DHEAS) 343:thecoma 186:gland. 134:oocytes 104:of the 27:Details 1899:G-spot 1862:Veins 1772:Septum 1765:Fascia 1719:Veins 1684:Corona 1426:Vagina 1386:Glands 1297:Layers 1260:Cervix 1248:Fundus 1243:Cavity 1223:Uterus 1119:Isthmi 1082:Oocyte 1044:Stroma 1034:Cortex 964:Thecae 952:Luteum 942:Corpus 916:Adnexa 779:  769:  746:  738:  730:  691:  681:  642:  586:  576:  532:  522:  477:  467:  444:  398:  350:(PCOS) 298:antral 284:theca. 276:oocyte 102:stroma 1892:Other 1680:Glans 1664:Angle 1630:Bulbs 1625:Crura 1597:Hymen 1585:Fossa 1493:Labia 1484:Vulva 1444:Walls 1439:Rugae 1434:Canal 1287:Horns 1265:Canal 1139:Ostia 1092:Ootid 1017:Other 744:S2CID 368:(FSH) 338:theca 333:ovary 159:with 106:ovary 54:[ 38:Latin 1647:Body 1620:Root 1305:Wall 1238:Body 1097:Ovum 799:link 795:link 777:OCLC 767:ISBN 736:PMID 728:ISSN 689:PMID 640:PMID 606:link 602:link 584:OCLC 574:ISBN 556:link 552:link 548:link 530:OCLC 520:ISBN 501:link 497:link 493:link 475:OCLC 465:ISBN 442:PMID 396:ISBN 362:(LH) 315:The 311:and 302:ovum 211:cAMP 132:and 66:The 849:373 838:372 720:doi 679:PMC 671:doi 632:doi 432:doi 428:140 1941:: 791:}} 787:{{ 775:. 742:. 734:. 726:. 716:38 714:. 710:. 687:. 677:. 665:. 661:. 638:. 628:37 626:. 614:^ 598:}} 594:{{ 582:. 544:}} 540:{{ 528:. 489:}} 485:{{ 473:. 440:. 426:. 422:. 410:^ 390:. 304:. 233:. 202:. 108:. 93:. 78:. 891:e 884:t 877:v 801:) 783:. 750:. 722:: 695:. 673:: 667:4 646:. 634:: 608:) 590:. 558:) 536:. 503:) 481:. 448:. 434:: 404:. 58:]

Index

Latin
Anatomical terminology
edit on Wikidata
ovarian follicles
secondary follicles
theca interna
theca externa
folliculogenesis
stroma
ovary

androgens
granulosa cells
oocytes

androstenedione
estradiol
granulosa cells
androstenedione
aromatase
estradiol
Gonadotropin releasing hormone
anterior pituitary
Gonadotrophs
follicle-stimulating hormone
luteinizing hormone
HPG axis
G-protein coupled receptors
cAMP
protein kinase A

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