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86:
Hans
Hartmann and his wife Liselotte (née Kolbe); he had two sisters, Sabine and Karoline. When his mother died in 1943, Hartmann and his sisters lived temporarily in the family of his uncle in Berlin. In 1951, Hans Hartmann married artist and teacher Tyra Hamann in
189:. There he headed the Institute of Pharmaceutical Biology for 28 years - from 1977 until his retirement in 2005. During this time, he initially worked on quinolizidine and, from 1982, pyrrolizidine alkaloids. Hartmann and co-workers elucidated the
177:
In 1973, he moved to the
Botanical Institute of the University of Bonn as a scientific advisor and professor, heading the Department of Biochemistry of Plants. There, Hartmann conducted research on ammonia metabolism and
669:
Starting in June 1984, he was Vice
President of the Technical University of Braunschweig, in addition Dean of the Departments of Chemistry, Pharmacy and Biosciences, and Chairman of the Faculty of Natural Sciences.
972:
1252:
445:) is 0.02% in alkaloids. Knowledge of alkaloid biosynthesis and the development of knowledge regarding genome and transcription for lupins are creating opportunities for the production of improved lupin plants.
617:
were analyzed by GC-MS and previously unknown compounds were identified. With one exception (senecivernine), all 26 alkaloids identified can be considered derivatives of senecionine with conversion of the
545:) selectively produces lolines (mainly N-formyl-loline, then also N-acetyl-loline, N-acetyl-norloline, and traces of loline and N-methyl-loline) as a specific response to infection with the
153:
as a postdoctoral fellow for one year (1964/1965) and returned to the
Pharmacognostic Institute in Bonn in 1965 as a research assistant. There he worked on amine formation in
588:(9-(2-hydroxy-3-methylbutanoyl)-retronecine), as well as other derivatives of these esters. In males, the creatonotines are direct precursors of the male mating pheromone
1176:: "Am 22. Juni 1984 wählte das Konzil der Technischen Universität Braunschweig den Leiter des Institutes für Pharmazeutische Biologie zum Vizepräsidenten."
592:. Hartmann et al. discuss the results in terms of pheromone formation and the defensive role of pyrrolizidine alkaloids against predators and parasites.
683:
103:
818:
The paper chromatographic quantitative determination of water vapor volatile biogenic amines, and studies on their biogenesis in
Claviceps purpurea
1222:
704:
675:
517:
defend themselves against predators by ingesting tertiary lycopsamine-type pyrrolizidine alkaloids (already in the larvae) of their host plant
169:
39:
718:
On August 28, 2003, he was co-founder of the Förderkreis des
Arzneipflanzengartens e.V. in Braunschweig and was elected as its first chairman.
1232:
658:
cannot be explained by the gain and loss of alkaloid-specific genes, but rather by switching gene expression of specific enzymes off and on.
1029:
Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three
Boraginaceae species
708:
186:
142:
67:
694:
568:, it has been outlined that larvae prefer food with an artificial enrichment of pyrrolizidine alkaloids, which they modify by specific
1247:
1104:
Sequestration, metabolism and partial synthesis of tertiary pyrrolizidine alkaloids by the neotropical leaf-beetle
Platyphora boucardi
1011:
Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase
847:Über das zeitliche Auftreten flüchtiger Amine und freier Aminosäuren in wachsenden, saprophytischen Kulturen von Claviceps Purpurea
1173:
482:
Biosynthesis, diversification and tissue distribution of lycopsamine alkaloids in three species of broadleaf plants (Boraginaceae)
973:
Biosynthesis of pyrrolizidine alkaloids: Putrescine and spermidine are essential substrates of enzymatic homospermidine formation
150:
862:
404:
Biochemical and biogenetic aspects of the biosynthesis of quinolizidine alkaloids in photomixotrophic cell suspension cultures
711:. In addition, he was a full member of the Braunschweig Scientific Society and, since 1999, a corresponding member of the
913:
Production of
Quinolizidine Alkaloids by Photomixotrophic Cell Suspension Cultures: Biochemical and Biogenetic Aspects 1
712:
528:
1227:
1066:
Tissue distribution and biosynthesis of 1,2-saturated pyrrolizidine alkaloids in
Phalaenopsis hybrids (Orchidaceae)
687:
492:
Biosynthesis and tissue distribution of 1,2-saturated pyrrolizidine alkaloids in Phalaenopsis hybrids (Orchidaceae)
430:, suggesting that in lupin leaves, lysine decarboxylase is an integral component of alkaloid-specific biosynthesis.
361:
765:
674:
He was involved in several scientific committees and societies, including the Scientific Advisory Board of the
146:
703:
Hartmann also served on the supervisory board of the Gesellschaft fĂĽr Biotechnologische Forschung (GBF; now
470:
375:
198:
179:
47:
1157:
Frequent gain and loss of pyrrolizidine alkaloids in the evolution of Senecio section Jacobaea (Asteraceae)
1122:
1046:
991:
934:
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31:
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912:
486:
318:
1242:
1237:
1142:
Phenological fate of plant-acquired pyrrolizidine alkaloidsin the polyphagous arctiid Estigmene acrea
793:
407:
194:
121:
865:
In Memoriam – Constant Collin Delwiche, Professor of Soil Biogeochemistry, Emeritus Davis, 1917–2001
291:
369:
585:
778:
Thomas Hartmann and Erika Orth married in 1964. They had three children and eight grandchildren.
651:
595:
Senecionine alkaloids are found as secondary metabolites in most species of the genus Greisweed (
251:
234:
208:
129:
115:
573:
222:
736:
Volume 45(2), February 2019 of the Journal of Chemical Ecology was dedicated to Thomas Hartmann
577:
1198:
1141:
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541:
532:
519:
466:
Biosynthetic incorporation of the aminobutyl group of spermidine into pyrrolizidine alkaloids.
438:
306:
1185:
992:
Biosynthetic incorporation of the aminobutyl group of spermidine into pyrrolizidine alkaloids
878:
Leucin-Carboxylyase aus marinen rhodophyceae: Vorkommen, Verbreitung und einige Eigenschaften
99:(Herchen), where he graduated from Bodelschwingh Gymnasium boarding school in February 1957.
1085:
Distribution, biosynthesis and turnover of pyrrolizidine alkaloids in Cynoglossum officinale
613:
279:
265:
1123:
Levels and tissue distribution of loline alkaloids in endophyte-infected Festuca pratensis
686:
in Jena, the advisory board of the Swiss National Centre of Competence in Research at the
639:
589:
564:
324:
125:
935:
Lysine decarboxylase in plants and its integration in quinolizidine alkaloid biosynthesis
690:, and the Commission of the Science Council for the Reform of State Examination Courses.
386:
91:, who had two adult daughters. Hartmann attended elementary and high schools in Berlin,
761:
From waste products to ecochemicals: Fifty years research of plant secondary metabolism
569:
426:
350:
1216:
679:
643:
631:
536:
420:
257:
214:
55:
51:
1200:
Personal Memories of Professor Thomas Hartmann, Chemical Ecologist in Heart and Soul
1047:
Pyrrolizidine alkaloids of the lycopsamine type: biosynthesis of trachelanthic acid
953:
162:
157:
and higher plants and on the occurrence and function of a L-leucine carboxylase in
43:
728:
Silver Medal Award of the International Society of Chemical Ecology (ISCE) in 1998
19:
635:
627:
581:
507:
442:
415:
271:
1103:
830:
Methode zur Quantitativen Trennung und Bestimmung flĂĽchtiger Pflanzlicher Amine
735:
603:
559:
550:
512:
504:
460:
456:
190:
1154:
P. B. Pelser, H.e de Vos, C. Theuring, T. Beuerle, K. Vrieling, T. Hartmann:
1156:
1065:
1010:
608:
546:
241:
158:
111:
92:
88:
83:
201:
and function of pyrrolizidine alkaloids in plants and their use in insects.
715:, as well as President of the International Society of Chemical Ecology.
102:
Starting in 1957, Hartmann studied chemistry, biology and sports at the
647:
597:
341:
96:
71:
35:
495:
Biosynthesis, distribution and turnover of pyrrolizidine alkaloids in
433:
Review article: Toxic quinolizidine metabolites present in the genus
337:
63:
38:
who was professor in the Department of Pharmaceutical Biology at the
441:) but not in seeds; the limit for commercial use as feed and food (
951:
T. Hatzold, I. Elmadfa, R. Gross, M. Wink, T. Hartmann, L. Witte:
693:
619:
385:
374:
360:
349:
154:
59:
18:
107:
654:. The results suggest that differences in alkaloid profiles in
630:
within the necin acid moiety. Other reactions include specific
477:(EC 2.5.1.46, spermidine:eIF5A-lysine 4-aminobutyltransferase).
1186:
Förderkreis des Arzneipflanzengartens e.V. der TU Braunschweig
336:
Hartmann published over 200 research articles (161 listed in
168:
794:
Bielefelder Stadtarchiv (Westfalen-Blatt, 15 February 2005)
1253:
Academic staff of the Technical University of Braunschweig
118:
at the Pharmacognostic Institute in Bonn (dissertation:
110:. He graduated in 1962 and subsequently completed his
1139:
T. Hartmann, C. Theuring, T. Beuerle, E. A. Bernays:
954:
Quinolizidine alkaloids in seeds of Lupinus mutabilis
463:
as substrates of enzymatic homospermidine formation.
1101:
T. Hartmann, C. Theuring, L. Witte, J. M. Pasteels:
1082:N. M. van Dam, L. Witte, C. Theuring, T. Hartmann:
30:, (February 2, 1937 – May 27, 2017), was a German
1145:, in Chemoecology (2004), vol. 14(3), p. 207-216.
1044:S. Weber, W. Eisenreich, A. Bacher, T.Hartmann:
932:G. Schoofs, S. Teichmann, T. Hartmann, M. Wink:
580:(9-(2-hydroxy-3-methylbutanoyl)-supinidine) and
524:and storing them selectively in defense glands.
128:, sowie Untersuchungen zu ihrer Biogenese bei
124:quantitative Bestimmung wasserdampfflĂĽchtiger
808:, Jubiläums-Festschrift, Herchen 1976, S. 172
82:Thomas Hartmann was born in Berlin as son of
8:
895:Prof Dr. Thomas Hartmann zum 60. Geburtstag
185:In 1976, Hartmann accepted a call from the
16:German pharmaceutical biologist (1937–2017)
698:Thomas Hartmann bei einer Exkursion (2013)
607:) and serve as a chemical defense against
418:content and alkaloid content of leaves in
806:Bodelschwingh-Gymnasium Herchen 1951–1976
707:- HZI) and was a trusted lecturer of the
684:Max Planck Institute for Chemical Ecology
410:activity in leaves of alkaloid-producing
473:(EC 2.5.1.44) evolved from the gene for
145:, Hartmann joined the research group of
104:Rheinische Friedrich-Wilhelms University
786:
705:Helmholtz Centre for Infection Research
676:Leibniz Institute of Plant Biochemistry
535:(GC-MS), it has been demonstrated that
489:(2,3-dihydroxy-2-isopropylbutyric acid)
247:
204:
70:of these secondary natural products by
1197:Jacques Pasteels und Nelida E. Gomez:
7:
1018:(1999), vol. 96(26), p. 14777-14782.
709:Studienstiftung des Deutschen Volkes
187:Technical University of Braunschweig
970:F. Böttcher, D. Ober, T. Hartmann:
769:, vol. 68 (2007), p. 2831–2846
611:. Twenty-four of the 26 species of
143:German National Academic Foundation
40:Technische Universität Braunschweig
1164:(2005), vol. 66(11), p. 1285-1295.
1120:M. Justus, L. Witte, T. Hartmann:
1111:(2001), vol. 31(11), p. 1041-1056.
1073:(2006), vol. 67(14), p. 1493-1502.
1063:C. Frölich, T. Hartmann, D. Ober:
1027:C. Frölich, D. Ober, T. Hartmann:
884:(1972), Band 11 (4), S. 1327-1336.
173:Reaktion der Glutamatdehydrogenase
14:
1054:(1999), vol. 50(6), p. 1005-1014.
1035:(2007), vol. 68(7), p. 1026-1037.
999:(1997), vol. 45(8), p. 1591-1595.
748:T. Hartmann und Walter Eschrich:
317:
305:
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114:in 1964 in the lab of biologist
1207:(2019), vol. 45(2), p. 107-108.
1174:Stadtchronik Braunschweig, 1984
1092:(1995), vol. 39(2), p. 287-292.
961:(1983), vol. 31(5), p. 934–938.
836:(1965), vol. 65(4), p. 315-333.
151:University of California, Davis
141:As a scholarship holder of the
1223:20th-century German biologists
756:, vol. 85(4), p. 303-312
622:base moiety retronecin to the
437:are desirable in plant parts (
42:. His research focused on the
1:
1130:(1997), vol. 44(1), p. 51-57.
980:(2011), vol. 72(1), p. 80-85.
978:Canadian Journal of Chemistry
942:(1983), vol. 22(1), p. 65-69.
853:(1965), vol. 66(1), p. 27-43.
1233:Scientists from Braunschweig
1188:; retrieved 19 January 2020.
732:In Memory of Thomas Hartmann
713:Bavarian Academy of Sciences
682:, the advisory board of the
529:capillary gas chromatography
455:Biosynthesis: importance of
1205:Journal of Chemical Ecology
414:correlates positively with
1269:
1016:Proc. Natl. Acad. Sci. USA
863:University of California:
750:Stofftransport in Rotalgen
634:, sometimes followed by O-
558:For the life cycle of the
1248:University of Bonn alumni
1109:Insect Biochem. Mol Biol.
368:mit deutlich erkennbarer
989:G. Graser, T. Hartmann:
804:Bernhard Harms (Hrsg.):
469:Evolution: the gene for
147:Constant Collin Delwiche
122:papierchromatographische
78:Early life and education
32:pharmaceutical biologist
688:University of Neuchâtel
471:homospermidine synthase
451:Pyrrolizidine alkaloids
400:Quinolizidine alkaloids
199:intracellular transport
180:glutamate dehydrogenase
48:intracellular transport
1008:D. Ober, T. Hartmann:
920:(1980), 40(10):149-155
910:M. Wink, T. Hartmann:
901:, vol. 44 (5), p. 767.
699:
555:up to seed maturation.
498:Cynoglossum officinale
475:deoxyhypusine synthase
395:
383:
372:
358:
357:(Vielblättrige Lupine)
174:
24:
23:Thomas Hartmann (2015)
743:Selected publications
697:
389:
378:
364:
353:
172:
22:
959:J. Agric. Food Chem.
626:moiety and specific
408:Lysine decarboxylase
195:compartmentalization
412:Lupinus polyphyllus
390:Jakobs-Greiskraut (
366:Platyphora boucardi
355:Lupinus polyphyllus
182:(GDH, EC 1.4.1.2).
165:in botany in 1969).
700:
487:trachelanthic acid
396:
384:
373:
359:
175:
130:Claviceps purpurea
116:Maximilian Steiner
25:
1228:German ecologists
542:Festuca pratensis
533:mass spectrometry
439:insect resistance
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723:Award and honors
665:Other activities
640:dehydrogenations
614:Senecio jacobaea
562:salt marsh moth
485:Biosynthesis of
392:Senecio jacobaea
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650:hydrolysis and
590:hydroxydanaidal
565:Estigmene acrea
510:of the species
380:Estigmene acrea
334:
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325:Hydroxydanaidal
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570:esterification
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864:
858:
850:
846:
841:
833:
829:
824:
817:
813:
805:
800:
789:
777:
764:
760:
753:
749:
731:
668:
655:
636:acetylations
628:epoxidations
612:
602:
596:
586:creatonotine
563:
549:
540:
518:
511:
508:leaf beetles
505:phytophagous
496:
450:
434:
425:
419:
411:
399:
391:
379:
365:
354:
342:
335:
297:
228:(+)-Lupanine
184:
176:
163:habilitation
140:
119:
101:
81:
44:biosynthesis
27:
26:
1243:2017 deaths
1238:1937 births
652:chlorolysis
638:, specific
582:retronecine
560:polyphagous
443:sweet lupin
416:chlorophyll
370:Warnfärbung
312:Senecionine
285:Lycopsamine
272:Retronecine
1217:Categories
782:References
609:herbivores
604:Asteraceae
574:supinidine
551:Acremonium
513:Platyphora
461:spermidine
457:putrescine
382:; Männchen
191:enzymology
893:M. Wink:
578:estigmine
553:uncinatum
547:endophyte
520:Prestonia
242:Sparteine
159:red algae
112:doctorate
93:Bielefeld
89:Bielefeld
84:architect
36:ecologist
624:otonecin
515:boucardi
347:= 42).
332:Research
66:and the
656:Senecio
648:epoxide
642:, E-/Z-
598:Senecio
435:Lupinus
97:Windeck
72:insects
851:Planta
834:Planta
754:Planta
646:, and
527:Using
345:-index
338:Scopus
137:Career
64:plants
1160:, in
1126:, in
1088:, in
1069:, in
1050:, in
1031:, in
1014:, in
995:, in
976:, in
957:, in
938:, in
916:, in
880:, in
620:necin
155:algae
60:fungi
503:The
459:and
424:and
240:(-)-
120:Die
108:Bonn
62:and
54:and
34:and
1203:in
1107:in
897:in
849:in
832:in
763:in
752:in
678:in
584:to
133:).
106:in
1219::
734::
601:;
572:-
340:,
197:,
193:,
149:,
74:.
46:,
922:.
738:.
539:(
531:/
394:)
343:h
298:N
161:(
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