201:, after which he received training in hematology at Boston Children's and Peter Bent Brigham Hospitals. He was chief of hematology-oncology at the Massachusetts General Hospital (1976–1991), head of experimental medicine at Brigham and Women's Hospital (1991–1998), and co-director of hematology (1998–2006) and translational medicine (2011–2014) at that institution. He served on the scientific advisory boards of Biogen, Inc. (1997–2002), Dyax, Inc. (1991–2001), and has been a director of Velico Medical Inc. since 2000. He was president of the American Society for Clinical Investigation and of the American Society of Hematology, served on the Lasker Awards' jury, and served as editor-in-chief of The Journal of Clinical Investigation and of Current Opinion in Hematology. Until his death, he was a member of the scientific advisory board of the Forsyth Dental Institute and a trustee of the
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scientific discoveries that harness the body's innate defense system to prevent serious outcomes. BioAegis exploits the multifunctional role of plasma gelsolin ("pGSN"), a highly conserved, endogenous human protein. pGSN is a master regulator—a key immune modulator that balances the inflammatory process to prevent the spread of excess inflammation while simultaneously enhancing antimicrobial defense. It is claimed to be a unique anti-inflammatory without immunosuppressive properties. In August 2019, BioAegis completed a Phase 1b/2a community-acquired pneumonia clinical trial. Based on pre-clinical efficacy evidence and the outcome of the clinical trial, BioAegis is now raising funding to launch a phase 2b trial in severe
221:, filamin and gelsolin, that regulate the assembly of actin. Gelsolin is also an abundant extracellular protein that circulates in blood plasma, and Stossel established that it is a component of innate immunity that promotes host antimicrobial activity and prevents the potentially lethal dissemination of inflammation. His company, BioAegis Therapeutics, is conducting clinical trials to assess the potential of plasma gelsolin therapy in a wide variety of infectious, inflammatory, and degenerative diseases.
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341:, was published by Rowman and Littlefield in 2015. He was a senior fellow of the Manhattan Institute (2008–2009) and a visiting scholar of the American Enterprise Institute (2014–2017). Stossel has been supportive of industry ethics since 1987, when he joined the scientific advisory board of Biogen. He was also critical of the
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Tom
Stossel was co-founder and chief scientific advisor to BioAegis, a clinical stage company focused on developing therapies for infectious, inflammatory, and degenerative diseases through a portfolio built around plasma gelsolin technology and therapeutics. The company is commercializing recent
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in Boston, Washington, DC, Philadelphia, and New York; and Tamara Sakala-Stossel, a graduate student at
Northeastern University. With his wife, Kerry Maguire, DDS, MSPH (a public health dentist who is vice president for clinical operations of the Forsyth Dental Institute,
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Stossel was a co-founder of
Options for Children in Zambia, which provides dental and medical preventive care and other services to the country's major teaching hospital, an orphanage, and remote rural villages. He also established Lusaka Zambia, a
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Stossel wrote extensively on policy issues related to medical research and on the relationships between academic researchers, physicians, and the medical products industry. His articles and op-eds have appeared in many publications, including The
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rule known as the
Physician Payments Sunshine Act, which requires all companies that sell medical products to the government to disclose on a public website anything they give to physicians that is valued above $ 10.
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structure and function in health and disease but predominantly focused on the molecular mechanism of how cells move and change shape. This research led to the discovery of two important cellular
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company developing a non-immunosuppressive anti-inflammatory with the potential to address a wide range of infectious, inflammatory, and degenerative diseases.
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designed to demonstrate definitively that plasma gelsolin repletion reduces morbidity and mortality.
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clinical and research center, in collaboration with physicians at the
University Teaching Hospital,
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https://ashpublications.org/ashclinicalnews/news/4773/Remembering-Thomas-P-Stossel-CPRIT-Awards-136
591:"Thomas P. Stossel, MD Prolific Researcher, Defender of Physician Industry Collaboration 1941-2019"
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521:"A Study to Evaluate Plasma Gelsolin in Healthy Volunteers - Full Text View - ClinicalTrials.gov"
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Stossel was the author of almost 300 publications, including co-authoring two textbooks,
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Pharmaphobia: How the
Conflict of Interest Myth Undermines American Medical Innovation
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Pharmaphobia: How the
Conflict of Interest Myth Undermines American Medical Innovation
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ideas on Fox News and other big news channels, he now runs his own
Youtube channel.
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652:"John Stossel's Transformation from Skeptical Libertarian to Polluter Apologist"
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546:"A Medical Leader Steps Up To Defend Biopharma: Tom Stossel's 'Pharmaphobia'"
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10.1182/hem.v17.1.10220/463521/thomas-p-stossel-md-1941-2019
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E Donnall Thomas Prize (American
Society of Hematology) 1993
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Kennedy and Class of 1868 Prizes (Princeton University) 1963
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and invented the BioAegis technology estate. He was also a
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McGovern Medal (American Medical Writers Association) 2010
153:(September 10, 1941 – September 29, 2019) was an American
489:"Ash Publications site in a tribute by Robert Handin, MD"
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Humanitarian Award (Brigham & Women's Hospital) 2012
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Elected, American Academy of Arts and Sciences (1996)
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and a professor emeritus of clinical research at the
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American Cancer Society Research Professorship 1987
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Dameshek Award (American Society of Hematology 1983
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379:Elected, National Academy of Medicine (1998)
376:Elected, National Academy of Sciences (1997)
314:Blood: Principles and Practice of Hematology
761:Members of the National Academy of Medicine
616:"About Us | Options for Children of Zambia"
358:Resnick Award (Harvard Medical School) 1967
197:in Boston and was a staff associate at the
310:Haematology: A Pathophysiological Approach
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331:Wall Street Journal, The Washington Post,
283:Learn how and when to remove this message
736:American people of German-Jewish descent
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213:Stossel's research included studies of
16:American physician-researcher 1941–2019
244:contains content that is written like
189:, graduating in 1963. He went on to
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120:Kerry Maguire (1997–2019; his death)
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118:Anne Hanford (1965–1997; divorced)
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316:(1997), and the consumer book
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185:Stossel majored in English at
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487:Handin, Robert (2023-03-22).
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771:Princeton University alumni
429:, cartoonist and author of
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56:Chicago Heights, Illinois
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731:American medical writers
209:Scientific contributions
199:National Heart Institute
75:Wellfleet, Massachusetts
467:Princeton Alumni Weekly
463:"Thomas P. Stossel '63"
171:American Cancer Society
716:American hematologists
620:optionsforchildren.org
191:Harvard Medical School
167:Harvard Medical School
595:Policy & Medicine
570:"Wall Street Journal"
422:, national editor of
265:neutral point of view
225:BioAegis Therapeutics
404:University of Zambia
187:Princeton University
181:Education and career
87:Princeton University
42:Thomas Peter Stossel
23:Thomas Peter Stossel
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400:sickle cell disease
343:Affordable Care Act
257:promotional content
681:www.britannica.com
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259:and inappropriate
163:professor emeritus
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67:September 29, 2019
52:September 10, 1941
756:Jewish physicians
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431:On the Loose
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251:Please help
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155:hematologist
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134:John Stossel
69:(2019-09-29)
711:2019 deaths
706:1941 births
444:libertarian
410:, Zambia.
324:Policy work
312:(1984) and
700:Categories
686:2023-07-12
662:2023-07-12
626:2023-07-12
601:2023-07-12
555:2023-07-12
530:2023-07-12
506:2023-03-22
473:2023-07-12
450:References
320:(2015).
253:improve it
48:1941-09-10
436:Cambridge
298:pneumonia
205:Health.
136:(brother)
125:Relatives
115:Spouse(s)
83:Education
575:July 12,
333:and The
219:proteins
159:gelsolin
175:biotech
550:Forbes
408:Lusaka
350:Awards
141:Awards
131:(son)
77:, U.S.
58:, U.S.
577:2015
64:Died
38:Born
497:doi
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