Knowledge

Thomas A. Steitz

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It should also be noted that Tom valued a good time. He always looked forward to department happy hours, wine tastings and any other excuse for a party. He hosted many wonderful Halloween parties at his home, always appropriately attire in
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Ludwig ML, Hartsuck JA, Steitz TA, Muirhead H, Coppola JC, Reeke GN, Lipscomb WN. The Structure of Carboxypeptidase A, IV. Prelimitary Results at 2.8 A Resolution, and a Substrate Complex at 6 A Resolution.
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While at Harvard, after the training task of determining the structure of the small molecule methyl ethylene phosphate, Steitz made contributions to determining the atomic structures of
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Steitz TA, Wiley DC, Lipscomb WN. The structure of aspartate transcarbamylase, I. A molecular twofold axis in the complex with cytidine triphosphate.
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and had one son, Jon, and two grandchildren, Adam and Maddy. He died on October 9, 2018, of complications during treatment of pancreatic cancer.
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Both Tom and Joan Steitz instead joined the Yale faculty in 1970, where he continued to work on cellular and structural biology. Steitz and
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in 2000. In 2009, Steitz was awarded the Nobel Prize in Chemistry for his ribosome research.
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Steitz did postdoctoral research as a Jane Coffin Childs Postdoctoral Fellow at the MRC
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Steitz, T. A. and Lipscomb, W. N., "Molecular Structure of Methyl Ethylene Phosphate,"
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catalyzed reaction, and for revealing the mechanism of inhibition of this function by
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Steitz was also one of the founders of a company, Rib-X Pharmaceuticals, now
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The Best Job Ever. Reflections On My Time with Tom Steitz, 1985–2018
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The Best Job Ever. Reflections On My Time with Tom Steitz, 1985–2018
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Yale Department of Molecular Biophysics & Biochemistry faculty
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in 1966 where he worked under the direction of subsequent 1976
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He received a Ph.D. in biochemistry and molecular biology from
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Structural Insights Into Gene Expression And Protein Synthesis
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Structural Insights Into Gene Expression And Protein Synthesis
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for the development of new antibiotics based on the ribosome.
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Lawrence University Graduate Awarded Nobel Prize in Chemistry
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Sterling Professor of Molecular Biophysics and Biochemistry
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Inquisitiveness of Milwaukee native leads to a Nobel Prize
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Members of the United States National Academy of Sciences
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Foreign Member of the Royal Society (ForMemRS) in 2011
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Steitz briefly held an assistant professorship at the
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Biographical Memoirs of Fellows of the Royal Society
314:(August 23, 1940 – October 9, 2018) was an American 3461: 3220: 2555: 2524: 2493: 2469: 2445: 2414: 2033: 1734: 1475: 1236: 1016: 293: 279: 269: 257: 239: 221: 200: 144: 136: 126: 118: 100: 81: 51: 32: 381:, Steitz studied chemistry as an undergraduate at 454:during 1976–1977 and a Fairchild Scholar at the 506: 247:The 6⁰A crystal structure of carboxypeptidase A 3190: 2668: 2390: 990: 808:Ramakrishnan, V.; Henderson, Richard (2021). 433:determined the atomic structure of the large 8: 3617:Deaths from pancreatic cancer in Connecticut 642: 640: 330:, best known for his pioneering work on the 3197: 3183: 3175: 2675: 2661: 2653: 2397: 2383: 2375: 997: 983: 975: 967: 40: 29: 825: 758: 2505:(Hong Kong/United Kingdom/United States) 575: 168:Gairdner Foundation International Award 954:Thomas Steitz – MIPtalk.com interview 581: 579: 7: 3607:Foreign members of the Royal Society 2694:Paul-Lewis Award in Enzyme Chemistry 893:. World Scientific. pp. 29–31. 3562:Howard Hughes Medical Investigators 674:. Lawrence University. 9 June 2010 456:California Institute of Technology 441:, and published their findings in 424:University of California, Berkeley 234:University of California, Berkeley 25: 3612:People from Branford, Connecticut 3572:American people of German descent 450:He was also a Macy Fellow at the 2684:Pfizer Award in Enzyme Chemistry 1227: 610:Kolata, Gina (10 October 2018). 417:Laboratory of Molecular Biology 328:Howard Hughes Medical Institute 226:Howard Hughes Medical Institute 27:American biochemist (1940–2018) 2548:(United Kingdom/United States) 2426:(United States/United Kingdom) 948:The Milwaukee Journal Sentinel 743:"Thomas A. Steitz (1940–2018)" 741:Ferry, Georgina (2018-10-30). 410:aspartate carbamoyltransferase 1: 661:, The Gairdner 50 Foundation. 632:2009 Nobel Prize in Chemistry 3582:Nobel laureates in Chemistry 337:Steitz was awarded the 2009 270:Other academic advisors 3633: 3567:Lawrence University alumni 3552:American crystallographers 881:Steitz, Thomas A. (2020). 760:10.1038/d41586-018-07187-2 326:, and investigator at the 160:Keio Medical Science Prize 3587:Scientists from Milwaukee 3557:Harvard University alumni 2700: 2690: 2580: 2536:(United States/Australia) 1225: 725:Proc Natl Acad Sci U S A. 708:Proc Natl Acad Sci U S A. 289: 193: 39: 3592:Yale Sterling Professors 3547:American Nobel laureates 2151:Venkatraman Ramakrishnan 1430:Wendell Meredith Stanley 1010:Nobel Prize in Chemistry 475:Nobel Prize in Chemistry 437:ribosomal subunit using 402:William N. Lipscomb, Jr. 343:Venkatraman Ramakrishnan 339:Nobel Prize in Chemistry 264:William N. Lipscomb, Jr. 176:Nobel Prize in Chemistry 3602:Yale University faculty 3145:Mohammad Seyedsayamdost 3061:Wilfred A. van der Donk 452:University of Göttingen 3542:American biophysicists 2586:Nobel Prize recipients 2526:Physiology or Medicine 2511:(Canada/United States) 2315:Emmanuelle Charpentier 2303:M. Stanley Whittingham 1274:Hans von Euler-Chelpin 827:10.1098/rsbm.2021.0029 565:List of RNA biologists 560:History of RNA biology 541:Steitz, T. A., et al. 530:Steitz, T. A., et al. 513:Steitz was married to 511: 353:which showed that the 3031:David W. Christianson 2877:Michael J. Chamberlin 1685:Christian B. Anfinsen 1325:FrĂ©dĂ©ric Joliot-Curie 519:Branford, Connecticut 439:X-ray crystallography 398:chemistry Nobel Prize 357:(EC 2.3.2.12) was an 105:Wauwatosa High School 93:Branford, Connecticut 3537:American biochemists 3399:Konstantin Novoselov 3049:Karin Musier-Forsyth 2865:Ekkehard K. F. Bautz 2819:Frederic M. Richards 2571:Oliver E. Williamson 2347:Karl Barry Sharpless 1844:Dudley R. Herschbach 1669:Luis Federico Leloir 649:, Thomas Steitz Lab. 547:NSLS Activity Report 463:Melinta Therapeutics 369:Education and career 355:peptidyl transferase 312:Thomas Arthur Steitz 152:Sir Hans Krebs Medal 56:Thomas Arthur Steitz 3489:Phillip Allen Sharp 2911:Frederik C. Hartman 2899:Stephen J. Benkovic 2893:Joseph L. Goldstein 2795:Frank M. Huennekens 2771:G. Robert Greenberg 2741:Bernard L. Horecker 2717:Albert L. Lehninger 2534:Elizabeth Blackburn 2339:Carolyn R. Bertozzi 2251:Jean-Pierre Sauvage 1988:Jens Christian Skou 1956:F. Sherwood Rowland 1868:Charles J. Pedersen 1832:Herbert A. Hauptman 1525:Vincent du Vigneaud 1142:Richard WillstĂ€tter 1026:Jacobus van 't Hoff 694:J Am. Chem. Soc. 87 634:, Nobel Foundation. 387:Appleton, Wisconsin 383:Lawrence University 122:Bio-crystallography 109:Lawrence University 3345:David Manolopoulos 2971:Kenneth A. Johnson 2929:Richard R. Burgess 2813:Marshall Nirenberg 2801:Jack L. Strominger 2424:Venki Ramakrishnan 2299:John B. Goodenough 2227:William E. Moerner 2107:Richard R. Schrock 2079:Roderick MacKinnon 2051:K. Barry Sharpless 1876:Johann Deisenhofer 1705:Geoffrey Wilkinson 1701:Ernst Otto Fischer 1625:Robert S. Mulliken 1561:Jaroslav HeyrovskĂœ 1509:Hermann Staudinger 1329:IrĂšne Joliot-Curie 966:on Nobelprize.org 905:(quote from p. 31) 887:by Peggy Eatheron" 854:by Peggy Eatheron" 616:The New York Times 538:, (November 2000). 458:during 1984–1985. 419:during 1967–1970. 408:(EC 3.4.17.1) and 406:carboxypeptidase A 394:Harvard University 213:Structural biology 113:Harvard University 3514: 3513: 3328:Steffen Lauritzen 3172: 3171: 3067:Nicole S. Sampson 3013:P. Andrew Karplus 2941:Robert T.N. Tjian 2883:Malcolm L. Gefter 2853:Herbert Weissbach 2847:Robert T. Schimke 2841:William J. Rutter 2777:Eugene P. Kennedy 2650: 2649: 2557:Economic Sciences 2462:(Germany/Romania) 2372: 2371: 2355:Moungi G. Bawendi 2275:Richard Henderson 2119:Roger D. Kornberg 2087:Aaron Ciechanover 1920:Rudolph A. Marcus 1824:Robert Merrifield 1760:Peter D. Mitchell 1533:Cyril Hinshelwood 1294:Friedrich Bergius 1218:Richard Zsigmondy 1134:Theodore Richards 1082:Ernest Rutherford 587:"Foreign Members" 309: 308: 195:Scientific career 172: 16:(Redirected from 3624: 3499:Thomas A. Steitz 3350:Gerhard Materlik 3323:Robert Kennicutt 3199: 3192: 3185: 3176: 3151:Kenichi Yokoyama 3127:Douglas Mitchell 3091:Virginia Cornish 3079:Neil L. Kelleher 3025:Ronald T. Raines 3019:Daniel Herschlag 2965:John W. Kozarich 2917:Thomas A. Steitz 2889:Michael S. Brown 2747:Earl R. Stadtman 2677: 2670: 2663: 2654: 2588: 2540:Carol W. Greider 2430:Thomas A. Steitz 2399: 2392: 2385: 2376: 2365: 2363:Alexei I. Ekimov 2349: 2343:Morten P. Meldal 2333: 2321: 2309: 2293: 2277: 2267:Jacques Dubochet 2261: 2245: 2229: 2213: 2197: 2191:Robert Lefkowitz 2185: 2177: 2161: 2155:Thomas A. Steitz 2145: 2129: 2121: 2113: 2103:Robert H. Grubbs 2097: 2081: 2069: 2053: 2026: 2024:Hideki Shirakawa 2010: 2002: 1990: 1974: 1958: 1942: 1934: 1922: 1914: 1912:Richard R. Ernst 1906: 1898: 1886: 1870: 1854: 1838: 1826: 1818: 1810: 1802: 1790: 1788:Frederick Sanger 1774: 1768:Herbert C. Brown 1762: 1754: 1746: 1744:William Lipscomb 1727: 1715: 1707: 1695: 1679: 1677:Gerhard Herzberg 1671: 1663: 1651: 1643: 1627: 1619: 1611: 1603: 1591: 1579: 1571: 1563: 1555: 1553:Frederick Sanger 1547: 1539: 1537:Nikolay Semyonov 1527: 1519: 1511: 1503: 1491: 1489:Glenn T. Seaborg 1468: 1456: 1448: 1440: 1432: 1416: 1414:Artturi Virtanen 1408: 1400: 1398:George de Hevesy 1392: 1391: 1385: 1384: 1378: 1377: 1371: 1359: 1351: 1339: 1331: 1319: 1311: 1310: 1304: 1296: 1284: 1276: 1264: 1256: 1254:Heinrich Wieland 1248: 1246:Theodor Svedberg 1231: 1230: 1220: 1212: 1211: 1205: 1197: 1189: 1181: 1173: 1172: 1166: 1158: 1157: 1151: 1150: 1144: 1136: 1128: 1120: 1108: 1100: 1092: 1084: 1076: 1068: 1060: 1058:Adolf von Baeyer 1052: 1044: 1042:Svante Arrhenius 1036: 1028: 999: 992: 985: 976: 971: 964:Thomas A. Steitz 931: 930: 928: 927: 918:. Archived from 912: 906: 904: 878: 872: 871: 846: 840: 839: 829: 805: 799: 798: 796: 794: 789:. 10 August 2000 779: 773: 772: 762: 738: 732: 721: 715: 703: 697: 690: 684: 683: 681: 679: 668: 662: 659:Thomas A. Steitz 656: 650: 644: 635: 629: 620: 619: 607: 601: 600: 598: 597: 583: 305: 302: 300: 280:Notable students 259:Doctoral advisor 253: 180: 170: 164: 156: 88: 65: 63: 44: 30: 21: 3632: 3631: 3627: 3626: 3625: 3623: 3622: 3621: 3517: 3516: 3515: 3510: 3457: 3313:Colin Humphreys 3303:Janet Hemingway 3273:Nicholas Franks 3253:Doreen Cantrell 3238:Jeremy Baumberg 3233:Andrew Balmford 3216: 3203: 3173: 3168: 2995:Michael H. Gelb 2935:Paul L. Mordich 2923:Daniel V. Santi 2871:Howard M. Temin 2825:Samuel B. Weiss 2807:Charles Gilvarg 2765:Merton F. Utter 2735:Arthur Kornberg 2696: 2686: 2681: 2651: 2646: 2584: 2576: 2573:(United States) 2567:(United States) 2551: 2546:Jack W. Szostak 2542:(United States) 2520: 2517:(United States) 2515:George E. Smith 2489: 2486:(United States) 2465: 2441: 2432:(United States) 2410: 2403: 2373: 2368: 2352: 2336: 2327:David MacMillan 2324: 2319:Jennifer Doudna 2312: 2296: 2280: 2264: 2255:Fraser Stoddart 2248: 2239:Paul L. Modrich 2232: 2216: 2200: 2188: 2180: 2175:Ei-ichi Negishi 2167:Richard F. Heck 2164: 2148: 2135:Osamu Shimomura 2132: 2124: 2116: 2100: 2084: 2072: 2056: 2043:William Knowles 2040: 2029: 2020:Alan MacDiarmid 2013: 2005: 1993: 1977: 1972:Richard Smalley 1961: 1948:Paul J. Crutzen 1945: 1937: 1925: 1917: 1909: 1901: 1889: 1873: 1864:Jean-Marie Lehn 1857: 1841: 1829: 1821: 1813: 1805: 1793: 1777: 1765: 1757: 1749: 1741: 1730: 1725:Vladimir Prelog 1718: 1710: 1698: 1682: 1674: 1666: 1654: 1646: 1630: 1622: 1617:Robert Woodward 1614: 1609:Dorothy Hodgkin 1606: 1594: 1582: 1574: 1566: 1558: 1550: 1542: 1530: 1522: 1514: 1506: 1494: 1482: 1471: 1459: 1454:William Giauque 1451: 1443: 1438:Robert Robinson 1435: 1422:James B. Sumner 1419: 1411: 1403: 1395: 1389: 1388: 1382: 1381: 1375: 1374: 1369:Leopold RuĆŸička 1365:Adolf Butenandt 1362: 1354: 1342: 1334: 1322: 1314: 1308: 1307: 1302:Irving Langmuir 1299: 1287: 1279: 1267: 1259: 1251: 1243: 1232: 1228: 1223: 1215: 1209: 1208: 1200: 1192: 1187:Frederick Soddy 1184: 1176: 1170: 1169: 1161: 1155: 1154: 1148: 1147: 1139: 1131: 1123: 1114:Victor Grignard 1111: 1103: 1095: 1090:Wilhelm Ostwald 1087: 1079: 1071: 1063: 1055: 1047: 1039: 1031: 1023: 1012: 1003: 939: 934: 925: 923: 914: 913: 909: 901: 880: 879: 875: 868: 848: 847: 843: 807: 806: 802: 792: 790: 781: 780: 776: 740: 739: 735: 731:(5): 1859–1861. 727:1967 November; 722: 718: 704: 700: 691: 687: 677: 675: 670: 669: 665: 657: 653: 645: 638: 630: 623: 609: 608: 604: 595: 593: 585: 584: 577: 573: 556: 536:nsls newsletter 527: 490: 471: 371: 324:Yale University 297: 251: 230:Yale University 217: 208:Crystallography 189: 178: 162: 154: 101:Alma mater 96: 90: 86: 85:October 9, 2018 77: 67: 66:August 23, 1940 61: 59: 58: 57: 47: 35: 28: 23: 22: 15: 12: 11: 5: 3630: 3628: 3620: 3619: 3614: 3609: 3604: 3599: 3594: 3589: 3584: 3579: 3574: 3569: 3564: 3559: 3554: 3549: 3544: 3539: 3534: 3529: 3519: 3518: 3512: 3511: 3509: 3508: 3505:Edward Stolper 3501: 3496: 3494:Carla J. 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Wells 2974: 2968: 2962: 2959:Gregory Petsko 2956: 2950: 2944: 2938: 2932: 2926: 2920: 2914: 2908: 2902: 2896: 2886: 2880: 2874: 2868: 2862: 2856: 2850: 2844: 2838: 2835:Salih J. Wakil 2831:P. Roy Vagelos 2828: 2822: 2816: 2810: 2804: 2798: 2792: 2786: 2780: 2774: 2768: 2762: 2756: 2750: 2744: 2738: 2732: 2729:Britton Chance 2726: 2723:Henry A. Lardy 2720: 2714: 2708: 2705:David E. Green 2701: 2698: 2697: 2691: 2688: 2687: 2682: 2680: 2679: 2672: 2665: 2657: 2648: 2647: 2645: 2644: 2639: 2634: 2629: 2624: 2619: 2614: 2609: 2604: 2599: 2594: 2589: 2581: 2578: 2577: 2575: 2574: 2568: 2561: 2559: 2553: 2552: 2550: 2549: 2543: 2537: 2530: 2528: 2522: 2521: 2519: 2518: 2512: 2506: 2503:Charles K. 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Steitz 489: 486: 485: 484: 478: 470: 467: 370: 367: 307: 306: 295: 291: 290: 287: 286: 281: 277: 276: 271: 267: 266: 261: 255: 254: 243: 237: 236: 223: 219: 218: 216: 215: 210: 204: 202: 198: 197: 191: 190: 188: 187: 181: 173: 165: 157: 148: 146: 142: 141: 138: 134: 133: 131:Joan A. Steitz 128: 124: 123: 120: 119:Known for 116: 115: 102: 98: 97: 91: 89:(aged 78) 83: 79: 78: 68: 55: 53: 49: 48: 46:Steitz in 2009 45: 37: 36: 33: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 3629: 3618: 3615: 3613: 3610: 3608: 3605: 3603: 3600: 3598: 3595: 3593: 3590: 3588: 3585: 3583: 3580: 3578: 3575: 3573: 3570: 3568: 3565: 3563: 3560: 3558: 3555: 3553: 3550: 3548: 3545: 3543: 3540: 3538: 3535: 3533: 3530: 3528: 3525: 3524: 3522: 3507: 3506: 3502: 3500: 3497: 3495: 3492: 3490: 3487: 3485: 3484:Thomas Hughes 3482: 3480: 3477: 3475: 3472: 3470: 3467: 3466: 3464: 3460: 3454: 3453:Robert Watson 3451: 3449: 3446: 3444: 3441: 3439: 3436: 3434: 3431: 3429: 3426: 3424: 3423: 3422:Mark Randolph 3419: 3417: 3414: 3412: 3411: 3407: 3405: 3402: 3400: 3397: 3395: 3392: 3390: 3387: 3385: 3382: 3380: 3379: 3378:Arthur Milner 3375: 3373: 3372: 3368: 3366: 3363: 3361: 3358: 3356: 3353: 3351: 3348: 3346: 3343: 3341: 3340: 3336: 3334: 3331: 3329: 3326: 3324: 3321: 3319: 3318:Alex Kacelnik 3316: 3314: 3311: 3309: 3306: 3304: 3301: 3299: 3296: 3294: 3291: 3289: 3286: 3284: 3281: 3279: 3276: 3274: 3271: 3269: 3266: 3264: 3261: 3259: 3256: 3254: 3251: 3249: 3248:BĂ©la BollobĂĄs 3246: 3244: 3241: 3239: 3236: 3234: 3231: 3229: 3226: 3225: 3223: 3219: 3215: 3211: 3210:Royal Society 3207: 3200: 3195: 3193: 3188: 3186: 3181: 3180: 3177: 3164: 3161: 3158: 3155: 3152: 3149: 3146: 3143: 3140: 3139:Emily Balskus 3137: 3134: 3131: 3128: 3125: 3122: 3119: 3116: 3113: 3110: 3107: 3104: 3101: 3098: 3095: 3092: 3089: 3086: 3085:Carsten Krebs 3083: 3080: 3077: 3074: 3071: 3068: 3065: 3062: 3059: 3056: 3055:Dorothee Kern 3053: 3050: 3047: 3044: 3043:Ruma Banerjee 3041: 3038: 3035: 3032: 3029: 3026: 3023: 3020: 3017: 3014: 3011: 3008: 3005: 3002: 2999: 2996: 2993: 2990: 2987: 2984: 2981: 2978: 2975: 2972: 2969: 2966: 2963: 2960: 2957: 2954: 2953:JoAnne Stubbe 2951: 2948: 2945: 2942: 2939: 2936: 2933: 2930: 2927: 2924: 2921: 2918: 2915: 2912: 2909: 2906: 2905:Paul Schimmel 2903: 2900: 2897: 2894: 2890: 2887: 2884: 2881: 2878: 2875: 2872: 2869: 2866: 2863: 2860: 2857: 2854: 2851: 2848: 2845: 2842: 2839: 2836: 2832: 2829: 2826: 2823: 2820: 2817: 2814: 2811: 2808: 2805: 2802: 2799: 2796: 2793: 2790: 2789:Arthur Pardee 2787: 2784: 2783:Minor J. 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Index

Thomas Steitz

Milwaukee
Wisconsin
Branford, Connecticut
Wauwatosa High School
Lawrence University
Harvard University
Joan A. Steitz
Sir Hans Krebs Medal
Keio Medical Science Prize
Gairdner Foundation International Award
Nobel Prize in Chemistry
ForMemRS
Crystallography
Structural biology
Howard Hughes Medical Institute
Yale University
University of California, Berkeley
Thesis
The 6⁰A crystal structure of carboxypeptidase A
Doctoral advisor
William N. Lipscomb, Jr.
David M. Blow
Nenad Ban
steitzlab.yale.edu
biochemist
Sterling Professor of Molecular Biophysics and Biochemistry
Yale University
Howard Hughes Medical Institute

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