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31:
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In July 2008, the company revised the prescribing information to restrict the use of tinzaparin in patients 90 years of age or older. FDA is concerned that the preliminary data from the IRIS study suggests that the increased risk of mortality is not limited only to patients 90 years of age or older.
665:
Sprigg N, Gray LJ, Bath PM, et al. (2007). "Early recovery and functional outcome are related with causal stroke subtype: data from the tinzaparin in acute ischemic stroke trial".
98:
413:. Healthcare professionals should consider the use of alternative treatments to Innohep when treating elderly patients over 70 years of age with chronic kidney disease and
334:
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68:
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453:
affect the international normalized ratio (INR), prothrombin time (PT). Anti-factor Xa levels can be measured, and are often used to monitor tinzaparin.
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397:. It was manufactured by Leo pharmaceutical company, who withdrew the product from the US in 2011 due to low sales and a contamination issue.
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According to the study
Innohep increases the risk of death for elderly patients (i.e., 70 years of age and older) with
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minor metabolisation in liver by desulfation and/or depolymerization; excretion via kidneys in almost unchanged form
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482:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
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Norfolk and
Norwich University Hospital (NHS Trust). Reference number CA3017. 9 June 2006
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Bleeding in overdose. There is occasionally bruising at the site of injection.
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Farmaceutiska
Specialiteter i Sverige - the Swedish official drug catalog.
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30:
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433:. Still, tinzaparin is often the LMWH of choice in pregnant women.
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697:
137:
489:
191:
200 min. for Anti-Xa activity, 257. min for Anti-IIa activity
644:
Hull, New
England Journal of Medicine, 2010 volume 22 page 19
638:
RCOG March-2010 (Royal college for
Obestetric and Gynecology)
518:
Pedersen P.C. et al. Thromb Res 1991; 61 (5-6): 477-487
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90% for Anti-Xa activity, 67% for Anti-IIa activity)
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464:will reverse tinzaparin by 85% per package insert.
429:No LMWH, except tinzaparin, is licensed for use in
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374:(FDA) for once daily treatment and prophylaxis of
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667:Journal of Stroke and Cerebrovascular Diseases
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632:(22)ESHRE April-2011 volume 33 pages 12–13-14
8:
47:, R = H and R = COONa or R = COONa and R = H
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679:10.1016/j.jstrokecerebrovasdis.2007.02.003
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657:at the U.S. National Library of Medicine
622:Therapeutic anticoagulation in pregnancy.
528:European Pharmacopoeia, 6th Edition, 2008
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370:worldwide. It has been approved by the
615:: CS1 maint: archived copy as title (
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538:Hull et al. NEJM 1992;326,15:975-982
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372:U.S. Food and Drug Administration
1331:Direct thrombin (IIa) inhibitors
759:Glycoprotein IIb/IIIa inhibitors
954:Thromboxane synthase inhibitors
431:gestational hypercoagulability
1:
1192:Low-molecular-weight heparin
1003:Phosphodiesterase inhibitors
916:Acetylsalicylic acid/Aspirin
364:low molecular weight heparin
1652:
317:Chemical and physical data
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1164:(with some II inhibition)
331:
327:6500 g/mol (average)
93:subcutaneous (once daily)
28:
659:Medical Subject Headings
35:n = 1 to 25, R = H or SO
1474:Plasminogen activators
946:Thromboxane inhibitors
870:Prostaglandin analogue
411:chronic kidney disease
1536:serine endopeptidases
1070:Vitamin K antagonists
562:"Drug Shortages List"
1283:Direct Xa inhibitors
1115:Ethyl biscoumacetate
981:Receptor antagonists
641:DVT.org/cardiologist
415:deep vein thrombosis
376:deep vein thrombosis
926:Carbasalate calcium
366:(LMWH) marketed as
25:
16:Pharmaceutical drug
1613:Never to phase III
1461:Thrombolytic drugs
1177:glycosaminoglycans
750:Antiplatelet drugs
737:antiplatelet drugs
419:pulmonary embolism
380:pulmonary embolism
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568:on 5 October 2016
462:Protamine sulfate
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23:Tinzaparin sodium
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1435:Drotrecogin alfa
1415:Antithrombin III
1266:Dermatan sulfate
1239:Oligosaccharides
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802:ADP receptor/P2Y
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449:Tinzaparin does
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385:It can be given
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635:e-medicine 2011
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591:"Archived copy"
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53:Clinical data
51:
39:Na, R = H, SO
32:
27:
19:
1550:Fibrinolysin
1520:Anistreplase
1498:Desmoteplase
1493:Tenecteplase
1394:Ximelagatran
1244:Fondaparinux
1231:
1183:antithrombin
1139:Diphenadione
1016:Dipyridamole
959:Dipyridamole
898:Treprostinil
893:Prostacyclin
772:Eptifibatide
673:(4): 180–4.
670:
666:
621:
599:. Retrieved
595:the original
570:. Retrieved
566:the original
556:
551:> Innohep
543:
534:
527:
523:
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505:
493:. Retrieved
485:
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460:
450:
448:
440:
437:Side effects
428:
408:
404:
384:
367:
358:drug in the
351:
350:
339:
333:
184:Elimination
129:Legal status
123:Legal status
18:
1599:from market
1420:Defibrotide
1348:Bivalirudin
1317:Rivaroxaban
1256:Heparinoids
1249:Idraparinux
1150:Tioclomarol
1144:Phenindione
1134:Clorindione
1037:Cloricromen
831:Ticlopidine
821:Clopidogrel
421:, or both.
306:100.110.590
196:Identifiers
59:Trade names
1525:Monteplase
1442:Ramatroban
1425:Nafamostat
1410:Abelacimab
1389:Melagatran
1374:Dabigatran
1369:Argatroban
1312:Otamixaban
1297:Betrixaban
1285:("xabans")
1271:Sulodexide
1261:Danaparoid
1232:Tinzaparin
1222:Parnaparin
1217:Nadroparin
1212:Enoxaparin
1207:Dalteparin
1202:Certoparin
1162:inhibitors
1110:Dicoumarol
1011:Cilostazol
991:Terutroban
969:Picotamide
858:Ticagrelor
842:nucleoside
838:Nucleotide
808:inhibitors
787:Sibrafiban
655:tinzaparin
495:22 October
468:References
445:Monitoring
378:(DVT) and
352:Tinzaparin
323:Molar mass
248:3S182ET3UA
223:ChemSpider
202:CAS Number
174:Metabolism
63:innohep(R)
43:Na or COCH
1609:Phase III
1597:Withdrawn
1513:Urokinase
1508:Saruplase
1488:Reteplase
1483:Alteplase
1430:Protein C
1384:Inogatran
1379:Efegatran
1365:Univalent
1358:Lepirudin
1353:Desirudin
1302:Darexaban
1227:Reviparin
1197:Bemiparin
1160:Factor Xa
1096:Coumarins
1073:(inhibit
1047:Vorapaxar
1021:Triflusal
986:Terbogrel
974:Terbogrel
963:+ aspirin
936:Triflusal
931:Indobufen
921:Aloxiprin
883:Beraprost
853:Elinogrel
848:Cangrelor
826:Prasugrel
792:Tirofiban
782:Roxifiban
777:Orbofiban
767:Abciximab
572:4 October
211:9041-08-1
186:half-life
87:Routes of
79:Monograph
73:Drugs.com
1636:Heparins
1630:Category
1339:Bivalent
1307:Edoxaban
1292:Apixaban
1125:Warfarin
1042:Ditazole
888:Iloprost
844:analogs
687:17689415
611:cite web
382:(PE).
342:(verify)
99:ATC code
1578:Oxalate
1568:Citrate
1545:Brinase
1343:Hirudin
1172:Heparin
1148:Other:
549:Fass.se
391:syringe
368:Innohep
360:heparin
145:WARNING
115:)
109: (
107:B01AB10
1592:WHO-EM
1540:Ancrod
1534:Other
1181:(bind
1174:group/
685:
661:(MeSH)
601:15 May
354:is an
279:ChEMBL
268:D06398
142:
1478:r-tPA
1403:Other
1030:Other
393:, or
1573:EDTA
1504:UPA
1447:REG1
874:PGI2
735:and
683:PMID
617:link
603:2010
574:2016
497:2023
259:KEGG
239:UNII
230:none
158:data
69:AHFS
1079:VII
741:B01
739:) (
675:doi
490:FDA
451:not
389:by
112:WHO
1632::
1605::
1538::
1476::
1367::
1341::
1132::
1098::
1085:,
1083:IX
1081:,
1077:,
1075:II
804:12
731:,
681:.
671:16
669:.
613:}}
609:{{
582:^
488:.
484:.
417:,
138:US
1463:/
1185:)
1179:/
1089:)
1087:X
965:)
961:(
876:)
872:(
840:/
743:)
727:(
717:e
710:t
703:v
689:.
677::
619:)
605:.
576:.
499:.
140::
71:/
45:3
41:3
37:3
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