244:
221:
118:
143:
495:
250:
149:
1339:
infection. These findings suggest that TLR7 not only plays a key role in triggering the immune response against COVID-19 but may also mediate the post-infectious sequalae in critically ill patients. Further research is required to fully delineate the mechanisms by which functional impairment of TLR7
1255:(shRNA), it has been demonstrated that the receptor TREML4 acts as an essential positive regulator of TLR7 signaling. In TREML4 -/- mice macrophages that are hyporesponsive to TLR7 agonists, macrophages fail to produce type I interferons due to impaired phosphorylation of the transcription factor
1267:
to TLR7. TREML4 deficiency reduced the production of inflammatory cytokines and autoantibodies in MRL/lpr mice, suggesting that TLR7 is a vital component of antiviral immunity and a predecessor factor in the pathogenesis of
1352:
variation in TLR7 disrupts immune tolerance, potentially increasing the risk of autoimmune disorders. In May 2022, unregulated gain-of function TLR7 variants were found to cause systemic lupus erythematous and
1662:
Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, et al. (February 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway".
257:
156:
2324:
1328:
1235:. TLR7 can recognize GU-rich single-stranded RNA. However, the presence of GU-rich sequences in the single-stranded RNA is not sufficient to stimulate TLR7.
838:
819:
79:
1354:
1327:
production. In July 2020, it was discovered that TLR7 deficiency predisposes young, previously healthy, male patients to severe infection with
1434:
1452:
Du X, Poltorak A, Wei Y, Beutler B (September 2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution".
1416:
1174:
2534:
1260:
2169:"Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus"
1881:"Delivery of TLR7 agonist to monocytes and dendritic cells by DCIR targeted liposomes induces robust production of anti-cancer cytokines"
2317:
243:
2450:
2435:
1077:
1783:"Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus"
1070:
220:
1479:
1931:"TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy"
1403:
1382:
2310:
1340:
influences the disease process and to explore the potential efficacy of targeting this pathway in the treatment of COVID-19.
1281:
1399:
142:
117:
1558:"HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses"
1378:
2539:
1734:"A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2"
1273:
59:
1978:
van der Made CI, Simons A, Schuurs-Hoeijmakers J, van den Heuvel G, Mantere T, Kersten S, et al. (August 2020).
256:
155:
1832:"From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation"
2034:"Novel TLR7 hemizygous variant in post-COVID-19 neurological deterioration: a case report with literature review"
1349:
249:
148:
1335:
loss-of-function variant was identified in a pediatric patient with severe neurological deterioration following
2296:
883:
67:
864:
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2440:
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2389:
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2115:
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Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF, Cowley GS, Root DE, et al. (May 2015).
1569:
1509:
1320:
1297:
1293:
1185:. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in
131:
46:
2333:
1615:"The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity"
1049:
1045:
1041:
1037:
990:
986:
982:
978:
2414:
2409:
2346:
2337:
2149:
1911:
1687:
1535:
1300:. Recent examples include TMX-202 delivery via liposomal formulation, as well as the delivery of
1243:
TLR7 has been shown to play a significant role in the pathogenesis of autoimmune disorders (e.g.
1182:
1152:
1148:
91:
2292:
1053:
1016:
974:
953:
2167:
Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, et al. (October 2018).
1781:
Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, et al. (March 2015).
2273:
2238:
2198:
2141:
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2011:
1960:
1903:
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1812:
1763:
1714:
1679:
1644:
1595:
1527:
1461:
1324:
1305:
1285:
1269:
1252:
1232:
39:
1929:
Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, et al. (August 2018).
1496:
Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, et al. (March 2004).
2263:
2230:
2188:
2180:
2131:
2123:
2055:
2045:
2001:
1991:
1950:
1942:
1895:
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1802:
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1745:
1671:
1634:
1626:
1585:
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1316:
336:
267:
211:
166:
2302:
1556:
Zhang Y, El-Far M, Dupuy FP, Abdel-Hakeem MS, He Z, Procopio FA, et al. (July 2016).
1164:
494:
311:
87:
2119:
2060:
2033:
1856:
1831:
1830:
Soni D, Borriello F, Scott DA, Feru F, DeLeon M, Brightman SE, et al. (July 2024).
1573:
1513:
2193:
2168:
2136:
2103:
2006:
1979:
1955:
1930:
1807:
1782:
1758:
1733:
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1614:
1590:
1557:
1289:
1224:
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753:
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541:
536:
2528:
2234:
2153:
523:
2084:
1498:"Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8"
1288:. Due to their ability to induce robust production of anti-cancer cytokines such as
71:
1915:
1691:
1539:
329:
108:
2102:
Brown GJ, Cañete PF, Wang H, Medhavy A, Bones J, Roco JA, et al. (May 2022).
2184:
1899:
1251:). Although not yet fully elucidated, using an unbiased genome-scale screen with
1163:
The TLR family plays an important role in pathogen recognition and activation of
95:
2085:"Type I interferon induction and signaling during SARS-CoV-2 infection (WP4868)"
1439:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1421:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1220:
2127:
2050:
1879:
Klauber TC, Laursen JM, Zucker D, Brix S, Jensen SS, Andresen TL (April 2017).
1787:
Proceedings of the
National Academy of Sciences of the United States of America
1749:
1177:(PAMPs) that are expressed on infectious agents, and mediate the production of
412:
1946:
1332:
1301:
1169:
228:
125:
75:
2083:
Pico A, Willighagen E, Ehrhart F, Pham N, Slenter D, Niarakis A, et al.
1996:
1798:
1732:
Yin Q, Luo W, Mallajosyula V, Bo Y, Guo J, Xie J, et al. (March 2023).
1522:
1497:
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1209:
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472:
350:
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83:
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2015:
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1865:
1847:
1816:
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1718:
1683:
1648:
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to humans and share structural and functional similarities. They recognize
1117:
1112:
1336:
1248:
1190:
1178:
1101:
928:
909:
2032:
Noor Eddin A, Al-Rimawi M, Peer-Zada F, Hundallah K, Alhashem A (2023).
1280:(Aldara), has been approved for topical use in treating warts caused by
1216:
1137:
895:
850:
1705:
Vender RB, Goldberg O (January 2005). "Innovative uses of imiquimod".
1581:
2508:
2498:
2483:
1194:
1085:
805:
1630:
1980:"Presence of Genetic Variants Among Young Men With Severe COVID-19"
2513:
2503:
2488:
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2463:
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1256:
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1213:
768:
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2430:
1198:
1186:
1144:
503:
63:
2306:
1228:
1205:
2256:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
2104:"TLR7 gain-of-function genetic variation causes human lupus"
1247:) as well as in the regulation of antiviral immunity (e.g.
2221:
Lien E, Ingalls RR (January 2002). "Toll-like receptors".
1227:. TLR7 recognizes single-stranded RNA of viruses such as
1197:, and lies in close proximity to another family member,
319:
1151:
are found in mammals and birds. It is a member of the
484:
714:
MyD88-dependent toll-like receptor signaling pathway
2449:
2423:
2345:
1030:
1009:
967:
946:
1395:
1393:
1391:
1374:
1372:
1370:
266:
165:
1292:, TLR7 agonists have also been investigated for
50:, TLR7-like, toll like receptor 7, IMD74, SLEB17
1331:. More recently in November 2023, a novel TLR7
1323:against viral infection by primarily affecting
709:positive regulation of interleukin-6 production
679:positive regulation of interleukin-8 production
1551:
1549:
1491:
1489:
1400:GRCm38: Ensembl release 89: ENSMUSG00000044583
1155:(TLR) family and detects single stranded RNA.
749:positive regulation of NIK/NF-kappaB signaling
2318:
8:
669:positive regulation of inflammatory response
2252:"Toll-like receptors as adjuvant receptors"
1379:GRCh38: Ensembl release 89: ENSG00000196664
1181:necessary for the development of effective
724:positive regulation of chemokine production
2325:
2311:
2303:
779:
519:
307:
206:
103:
2295:at the U.S. National Library of Medicine
2267:
2192:
2135:
2059:
2049:
2005:
1995:
1954:
1855:
1806:
1757:
1638:
1589:
1521:
1263:and decreased recruitment of the adaptor
537:transmembrane signaling receptor activity
1480:"Entrez Gene: TLR7 toll-like receptor 7"
699:cellular response to mechanical stimulus
1366:
1175:pathogen-associated molecular patterns
734:toll-like receptor 7 signaling pathway
674:toll-like receptor 9 signaling pathway
20:
2027:
2025:
689:regulation of protein phosphorylation
557:pattern recognition receptor activity
271:
232:
227:
170:
129:
124:
7:
1261:mitogen-activated protein kinase p38
684:toll-like receptor signaling pathway
2250:Kaisho T, Akira S (February 2002).
754:I-kappaB kinase/NF-kappaB signaling
1027:
1006:
964:
943:
919:
900:
874:
855:
829:
810:
489:
407:
345:
324:
14:
1167:. TLRs are highly conserved from
1140:that in humans is encoded by the
2235:10.1097/00003246-200201001-00001
1204:TLR7 recognizes single-stranded
493:
255:
248:
242:
219:
154:
147:
141:
116:
1707:Journal of Drugs in Dermatology
1212:, which is a common feature of
1344:Gain-of-Function TLR7 Variants
1319:variants in TLR7 diminish the
1312:Loss-of-Function TLR7 Variants
1304:via nanoparticles formed from
643:endoplasmic reticulum membrane
573:integral component of membrane
504:More reference expression data
473:More reference expression data
1:
2269:10.1016/S0167-4889(01)00182-3
1935:Nature Biomedical Engineering
1201:, on the human X chromosome.
240:
139:
2185:10.1016/j.immuni.2018.08.015
1900:10.1016/j.actbio.2017.01.072
1274:systemic lupus erythematosus
2535:Genes on human chromosome X
1245:systemic lupus erythematous
552:single-stranded RNA binding
542:double-stranded RNA binding
455:subcutaneous adipose tissue
2556:
2128:10.1038/s41586-022-04642-z
2051:10.3389/fneur.2023.1268035
1750:10.1038/s41563-022-01464-2
1219:which are internalized by
704:microglial cell activation
1947:10.1038/s41551-018-0236-8
1454:European Cytokine Network
1435:"Mouse PubMed Reference:"
1417:"Human PubMed Reference:"
1116:
1111:
1107:
1100:
1084:
1078:Chr X: 166.09 – 166.11 Mb
1065:
1034:
1013:
1002:
971:
950:
939:
926:
922:
907:
903:
894:
881:
877:
862:
858:
849:
836:
832:
817:
813:
804:
789:
782:
778:
762:
694:defense response to virus
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
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306:
289:
276:
239:
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188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
2297:Medical Subject Headings
659:I-kappaB phosphorylation
1997:10.1001/jama.2020.13719
1799:10.1073/pnas.1424924112
1523:10.1126/science.1093620
1276:(SLE). A TLR7 agonist,
1071:Chr X: 12.87 – 12.89 Mb
16:Protein found in humans
2223:Critical Care Medicine
2038:Frontiers in Neurology
1848:10.1126/sciadv.adg3747
1321:innate immune response
739:innate immune response
451:mesenteric lymph nodes
2451:Downstream signalling
1239:Clinical significance
744:inflammatory response
664:immune system process
628:endolysosome membrane
618:endoplasmic reticulum
423:stroma of bone marrow
393:right coronary artery
2293:Toll-Like+Receptor+7
1355:neuromyelitis optica
1294:cancer immunotherapy
1130:Toll-like receptor 7
234:X chromosome (mouse)
132:X chromosome (human)
2540:Toll-like receptors
2120:2022Natur.605..349B
1574:2016NatSR...629447Z
1514:2004Sci...303.1526H
1508:(5663): 1526–1529.
719:signal transduction
583:cytoplasmic vesicle
2229:(1 Suppl): S1-11.
1888:Acta Biomaterialia
1562:Scientific Reports
1270:rheumatic diseases
1153:toll-like receptor
884:ENSMUSG00000044583
652:Biological process
603:phagocytic vesicle
566:Cellular component
530:Molecular function
2522:
2521:
2340:signaling pathway
2334:Signaling pathway
2179:(4): 725–739.e6.
2114:(7909): 349–356.
1793:(12): 3680–3685.
1664:Nature Immunology
1619:Nature Immunology
1582:10.1038/srep29447
1306:beta-cyclodextrin
1286:actinic keratosis
1253:short hairpin RNA
1127:
1126:
1123:
1122:
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1095:
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1060:
1024:
1023:
998:
997:
961:
960:
935:
934:
916:
915:
890:
889:
871:
870:
845:
844:
826:
825:
774:
773:
638:endosome membrane
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
2547:
2327:
2320:
2313:
2304:
2281:
2271:
2246:
2207:
2206:
2196:
2164:
2158:
2157:
2139:
2099:
2093:
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2080:
2074:
2073:
2063:
2053:
2029:
2020:
2019:
2009:
1999:
1975:
1969:
1968:
1958:
1926:
1920:
1919:
1885:
1876:
1870:
1869:
1859:
1842:(27): eadg3747.
1836:Science Advances
1827:
1821:
1820:
1810:
1778:
1772:
1771:
1761:
1738:Nature Materials
1729:
1723:
1722:
1702:
1696:
1695:
1659:
1653:
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1610:
1604:
1603:
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1525:
1493:
1484:
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1449:
1443:
1442:
1431:
1425:
1424:
1413:
1407:
1397:
1386:
1376:
1350:gain-of-function
1317:Loss-of-function
1132:, also known as
1109:
1108:
1080:
1073:
1056:
1028:
1019:
1007:
1003:RefSeq (protein)
993:
965:
956:
944:
920:
901:
875:
856:
830:
811:
780:
598:receptor complex
520:
506:
497:
490:
475:
415:
413:Top expressed in
408:
353:
351:Top expressed in
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325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
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145:
134:
120:
104:
98:
96:TLR7 - orthologs
49:
42:
21:
2555:
2554:
2550:
2549:
2548:
2546:
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2544:
2525:
2524:
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2518:
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2424:Other receptors
2419:
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2220:
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2214:Further reading
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1703:
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1631:10.1038/ni.3143
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1611:
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1410:
1398:
1389:
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1368:
1363:
1346:
1314:
1296:and as vaccine
1241:
1225:dendritic cells
1165:innate immunity
1161:
1118:View/Edit Mouse
1113:View/Edit Human
1076:
1069:
1066:Location (UCSC)
1052:
1048:
1044:
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989:
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981:
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952:
865:ENSG00000196664
758:
729:immune response
647:
623:plasma membrane
588:early phagosome
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385:parietal pleura
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210:Gene location (
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107:Gene location (
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2287:External links
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1990:(7): 663–673.
1970:
1941:(8): 578–588.
1921:
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1822:
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1744:(3): 380–390.
1724:
1697:
1670:(2): 196–200.
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1625:(5): 495–504.
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1471:
1460:(3): 362–371.
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1290:interleukin-12
1282:papillomavirus
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645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
590:
585:
580:
578:Golgi membrane
575:
569:
567:
563:
562:
560:
559:
554:
549:
544:
539:
533:
531:
527:
526:
516:
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342:
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316:
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312:RNA expression
304:
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291:
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286:
278:
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264:
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100:
99:
56:
52:
51:
43:
35:
34:
30:
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26:
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15:
13:
10:
9:
6:
4:
3:
2:
2552:
2541:
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2507:
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2298:
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2279:
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2265:
2261:
2257:
2253:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2219:
2218:
2213:
2204:
2200:
2195:
2190:
2186:
2182:
2178:
2174:
2170:
2163:
2160:
2155:
2151:
2147:
2143:
2138:
2133:
2129:
2125:
2121:
2117:
2113:
2109:
2105:
2098:
2095:
2090:
2086:
2079:
2076:
2071:
2067:
2062:
2057:
2052:
2047:
2043:
2039:
2035:
2028:
2026:
2022:
2017:
2013:
2008:
2003:
1998:
1993:
1989:
1985:
1981:
1974:
1971:
1966:
1962:
1957:
1952:
1948:
1944:
1940:
1936:
1932:
1925:
1922:
1917:
1913:
1909:
1905:
1901:
1897:
1893:
1889:
1882:
1875:
1872:
1867:
1863:
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1853:
1849:
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1833:
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1814:
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1800:
1796:
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1760:
1755:
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1743:
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1728:
1725:
1720:
1716:
1712:
1708:
1701:
1698:
1693:
1689:
1685:
1681:
1677:
1676:10.1038/ni758
1673:
1669:
1665:
1658:
1655:
1650:
1646:
1641:
1636:
1632:
1628:
1624:
1620:
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1597:
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1563:
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1388:
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1371:
1367:
1360:
1358:
1356:
1351:
1348:In contrast,
1343:
1341:
1338:
1334:
1330:
1326:
1322:
1318:
1311:
1309:
1307:
1303:
1299:
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1234:
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1188:
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1110:
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1103:
1099:
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1090:
1087:
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1079:
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1068:
1064:
1057:
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1033:
1029:
1026:
1020:
1018:
1012:
1008:
1005:
1001:
994:
992:
988:
984:
980:
976:
970:
966:
963:
957:
955:
949:
945:
942:
940:RefSeq (mRNA)
938:
931:
930:
925:
921:
918:
912:
911:
906:
902:
899:
897:
893:
886:
885:
880:
876:
873:
867:
866:
861:
857:
854:
852:
848:
841:
840:
835:
831:
828:
822:
821:
816:
812:
809:
807:
803:
800:
797:
795:
792:
788:
785:
781:
777:
770:
766:
761:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
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700:
697:
695:
692:
690:
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685:
682:
680:
677:
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672:
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662:
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651:
650:
644:
641:
639:
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634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
579:
576:
574:
571:
570:
568:
565:
564:
558:
555:
553:
550:
548:
547:siRNA binding
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
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421:
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414:
409:
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396:
392:
388:
384:
380:
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372:
368:
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
2384:
2259:
2255:
2226:
2222:
2176:
2172:
2162:
2111:
2107:
2097:
2089:WikiPathways
2088:
2078:
2041:
2037:
1987:
1983:
1973:
1938:
1934:
1924:
1891:
1887:
1874:
1839:
1835:
1825:
1790:
1786:
1776:
1741:
1737:
1727:
1713:(1): 58–63.
1710:
1706:
1700:
1667:
1663:
1657:
1622:
1618:
1608:
1565:
1561:
1505:
1501:
1474:
1457:
1453:
1447:
1438:
1429:
1420:
1411:
1347:
1315:
1242:
1203:
1168:
1162:
1141:
1133:
1129:
1128:
1050:NP_001277687
1046:NP_001277686
1042:NP_001277685
1038:NP_001277684
1035:
1014:
991:NM_001290758
987:NM_001290757
983:NM_001290756
979:NM_001290755
972:
951:
927:
908:
882:
863:
837:
818:
798:
793:
335:
328:
294:166,113,554
281:166,087,925
55:External IDs
18:
2262:(1): 1–13.
2044:: 1268035.
1894:: 367–377.
1357:in humans.
1221:macrophages
427:granulocyte
381:gallbladder
365:granulocyte
273:X|X F5
193:12,890,361
180:12,867,072
33:Identifiers
2529:Categories
1406:, May 2017
1385:, May 2017
1361:References
1333:hemizygous
1329:SARS-CoV-2
1325:interferon
1302:resiquimod
1170:Drosophila
373:lymph node
339:(ortholog)
76:HomoloGene
2154:248414899
1568:: 29447.
1298:adjuvants
1278:imiquimod
1210:endosomes
1179:cytokines
1149:Orthologs
1054:NP_573474
1017:NP_057646
975:NM_133211
954:NM_016562
784:Orthologs
633:cytoplasm
84:GeneCards
2278:11909637
2243:11782555
2203:30314758
2173:Immunity
2146:35477763
2070:38093758
2061:10716429
2016:32706371
1965:31015631
1908:28153581
1866:38959314
1857:11221515
1817:25775551
1768:36717665
1719:15696986
1684:11812998
1649:25848864
1600:27385120
1532:14976262
1466:11022119
1402:–
1381:–
1337:COVID-19
1284:and for
1272:such as
1249:COVID-19
1191:placenta
1183:immunity
1159:Function
1102:Wikidata
763:Sources:
613:lysosome
608:membrane
593:endosome
435:calvaria
397:placenta
377:appendix
369:testicle
361:monocyte
2194:6217820
2137:9095492
2116:Bibcode
2007:7382021
1956:6192054
1916:3395044
1808:4378396
1759:9981462
1692:1694900
1640:4406861
1591:4935957
1570:Bibcode
1540:1680581
1510:Bibcode
1502:Science
1404:Ensembl
1383:Ensembl
1259:by the
1217:genomes
1138:protein
1136:, is a
896:UniProt
851:Ensembl
790:Species
769:QuickGO
314:pattern
72:2176882
40:Aliases
2509:TOLLIP
2499:TICAM1
2484:MAP3K7
2299:(MeSH)
2276:
2241:
2201:
2191:
2152:
2144:
2134:
2108:Nature
2068:
2058:
2014:
2004:
1963:
1953:
1914:
1906:
1864:
1854:
1815:
1805:
1766:
1756:
1717:
1690:
1682:
1647:
1637:
1598:
1588:
1538:
1530:
1464:
1195:spleen
1193:, and
1088:search
1086:PubMed
929:P58681
910:Q9NYK1
839:170743
806:Entrez
485:BioGPS
459:thymus
447:embryo
443:embryo
431:spleen
389:rectum
172:Xp22.2
64:300365
2514:TRAF6
2504:TIRAP
2489:MYD88
2474:IRAK4
2469:IRAK3
2464:IRAK2
2459:IRAK1
2415:TLR13
2410:TLR12
2405:TLR11
2400:TLR10
2150:S2CID
1912:S2CID
1884:(PDF)
1688:S2CID
1536:S2CID
1265:MYD88
1257:STAT1
1214:viral
820:51284
799:Mouse
794:Human
765:Amigo
439:blood
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
80:75060
2494:TAB1
2479:IRF3
2431:CD14
2395:TLR9
2390:TLR8
2385:TLR7
2380:TLR6
2375:TLR5
2370:TLR4
2365:TLR3
2360:TLR2
2355:TLR1
2347:TLRs
2274:PMID
2260:1589
2239:PMID
2199:PMID
2142:PMID
2066:PMID
2012:PMID
1984:JAMA
1961:PMID
1904:PMID
1862:PMID
1813:PMID
1764:PMID
1715:PMID
1680:PMID
1645:PMID
1596:PMID
1528:PMID
1462:PMID
1231:and
1223:and
1199:TLR8
1187:lung
1145:gene
1142:TLR7
1134:TLR7
320:Bgee
268:Band
229:Chr.
167:Band
126:Chr.
88:TLR7
60:OMIM
47:TLR7
24:TLR7
2441:MD2
2436:LBP
2338:TLR
2264:doi
2231:doi
2189:PMC
2181:doi
2132:PMC
2124:doi
2112:605
2056:PMC
2046:doi
2002:PMC
1992:doi
1988:324
1951:PMC
1943:doi
1896:doi
1852:PMC
1844:doi
1803:PMC
1795:doi
1791:112
1754:PMC
1746:doi
1672:doi
1635:PMC
1627:doi
1586:PMC
1578:doi
1518:doi
1506:303
1308:.
1233:HCV
1229:HIV
1208:in
1206:RNA
290:End
189:End
92:OMA
68:MGI
2531::
2336::
2272:.
2258:.
2254:.
2237:.
2227:30
2225:.
2197:.
2187:.
2177:49
2175:.
2171:.
2148:.
2140:.
2130:.
2122:.
2110:.
2106:.
2087:.
2064:.
2054:.
2042:14
2040:.
2036:.
2024:^
2010:.
2000:.
1986:.
1982:.
1959:.
1949:.
1937:.
1933:.
1910:.
1902:.
1892:53
1890:.
1886:.
1860:.
1850:.
1840:10
1838:.
1834:.
1811:.
1801:.
1789:.
1785:.
1762:.
1752:.
1742:22
1740:.
1736:.
1709:.
1686:.
1678:.
1666:.
1643:.
1633:.
1623:16
1621:.
1617:.
1594:.
1584:.
1576:.
1564:.
1560:.
1548:^
1534:.
1526:.
1516:.
1504:.
1500:.
1488:^
1458:11
1456:.
1437:.
1419:.
1390:^
1369:^
1189:,
1147:.
767:/
296:bp
283:bp
195:bp
182:bp
90:;
86::
82:;
78::
74:;
70::
66:;
62::
2326:e
2319:t
2312:v
2280:.
2266::
2245:.
2233::
2205:.
2183::
2156:.
2126::
2118::
2091:.
2072:.
2048::
2018:.
1994::
1967:.
1945::
1939:2
1918:.
1898::
1868:.
1846::
1819:.
1797::
1770:.
1748::
1721:.
1711:4
1694:.
1674::
1668:3
1651:.
1629::
1602:.
1580::
1572::
1566:6
1542:.
1520::
1512::
1482:.
1468:.
1441:.
1423:.
214:)
111:)
94::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
