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Toll-like receptor 3

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324: 301: 198: 223: 2319: 575: 2304: 330: 229: 31: 1524:, and activation of TLR3 signaling is associated with ischemic preconditioning-induced protection against brain ischemia and attenuation of reactive astrogliosis. Furthermore, TLR3 activation has been shown to promote hair follicle regeneration in skin wound healing. In addition, TLR3 activators show effects on human vascular cells. 57: 1501:. Additionally, an ephemeral form of double-stranded RNA exists as a replicative intermediate during virus replication. Upon recognition, TLR3 induces the activation of IRF3 to increase production of 1544:, but on one face (including the proposed interface between the two horseshoes), there is a large sugar-free surface. This surface also contains two distinct patches rich in positively charged 3220: 2359: 1442:
TLR3 is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from
337: 236: 1536:. TLR3 forms a large horseshoe shape that contacts with a neighboring horseshoe, forming a "dimer" of two horseshoes. Much of the TLR3 protein surface is covered with 4396: 3210: 2318: 1454:
necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in
2164:"Polyinosinic-polycytidylic acid has therapeutic effects against cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via TLR3" 1816:
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (October 2001). "Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3".
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to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (
1385: 2207:"TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia" 1982:"TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia" 2813: 2276: 329: 228: 3997: 2892: 2078:
Choe J, Kelker MS, Wilson IA (July 2005). "Crystal structure of human toll-like receptor 3 (TLR3) ectodomain".
1143: 147: 3961: 1463: 1124: 3304: 3299: 3294: 3284: 2591: 2519: 1482:. Unlike other TLRs, TLR3 uses TRIF as the sole adaptor. IRF3 ultimately induces the production of type I 4512: 4476: 4471: 2648: 2566: 1556: 4466: 4461: 4456: 4451: 4446: 4441: 4431: 4426: 3885: 3598: 2269: 2087: 1934: 1825: 1683: 1408: 211: 126: 4405: 3912: 3731: 1506: 1297: 1293: 1242: 1238: 4486: 4481: 4418: 4409: 3319: 3053: 2111: 1849: 1400: 171: 1289: 1268: 1234: 1213: 1870:
Cole JE, Navin TJ, Cross AJ, Goddard ME, Alexopoulou L, Mitra AT, et al. (February 2011).
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Nelson AM, Reddy SK, Ratliff TS, Hossain MZ, Katseff AS, Zhu AS, et al. (August 2015).
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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negative regulation of MyD88-independent toll-like receptor signaling pathway
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Li Y, Xu XL, Zhao D, Pan LN, Huang CW, Guo LJ, et al. (November 2015).
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Li Y, Xu XL, Zhao D, Pan LN, Huang CW, Guo LJ, et al. (November 2015).
1888: 1467: 1416: 1043: 552: 430: 375: 362: 274: 261: 163: 30: 2240: 2197: 2154: 2107: 2064: 2031:"dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration" 2015: 1966: 1907: 1845: 1759: 1872:"Unexpected protective role for Toll-like receptor 3 in the arterial wall" 1715: 1696: 1548:, which may be a binding site for negatively charged double-stranded RNA. 1361: 1356: 4348: 4248: 4062: 4047: 3250: 3245: 3153: 2843: 2162:
Wang PF, Fang H, Chen J, Lin S, Liu Y, Xiong XY, et al. (May 2014).
1573: 1498: 1479: 1459: 1455: 1451: 1450:) that are expressed on infectious agents, and mediate the production of 1345: 1188: 1169: 1555:, TLR3 crystallises readily – a prerequisite for structural analysis by 4298: 4293: 4288: 4188: 4002: 3992: 3819: 3798: 3793: 3761: 3566: 3486: 3481: 3476: 3471: 3466: 3384: 3077: 2917: 2912: 2907: 2902: 2897: 2368: 2327:: The molecular structure of toll-like receptor 3 ligand binding domain 1670:
Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (January 1998).
1423: 1389: 1155: 1110: 2222: 1997: 96: 92: 88: 84: 80: 76: 4580: 4570: 4555: 4238: 4198: 4183: 4167: 4162: 4142: 4137: 4072: 3880: 3850: 3814: 3805: 3618: 3586: 3450: 3445: 3415: 3394: 3354: 3314: 3180: 3158: 3117: 3041: 3036: 3031: 3026: 3021: 3016: 2885: 2880: 2875: 2823: 2808: 2678: 2668: 2631: 2626: 2544: 2539: 1837: 1672:"A family of human receptors structurally related to Drosophila Toll" 1329: 1065: 4585: 4575: 4560: 4545: 4540: 4535: 4530: 4363: 4338: 4258: 4253: 4243: 4233: 4218: 4213: 4208: 4193: 4147: 4132: 4097: 4082: 4077: 4067: 3987: 3982: 3977: 3956: 3952: 3942: 3855: 3756: 3751: 3710: 3660: 3655: 3650: 3645: 3630: 3623: 3603: 3591: 3534: 3529: 3524: 3514: 3509: 3502: 3440: 3430: 3425: 3420: 3410: 3389: 3379: 3344: 3339: 3334: 3329: 3324: 3279: 3274: 3240: 3205: 3200: 3195: 3185: 3173: 3168: 3148: 3143: 3138: 3133: 3087: 2979: 2974: 2793: 2777: 2770: 2765: 2760: 2755: 2750: 2745: 2720: 2698: 2693: 2586: 2512: 2507: 2497: 1537: 1532:
The structure of TLR3 was reported in June 2005 by researchers at
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which signal other cells to increase their antiviral defenses.
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associated with viral infection, and induces the activation of
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Pan LN, Zhu W, Li Y, Xu XL, Guo LJ, Lu Q, et al. (2014).
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positive regulation of NF-kappaB transcription factor activity
2312:: Human Toll-like Receptor 3 extracellular domain structure 1486:. It may thus play a role in host defense against viruses. 764:
positive regulation of toll-like receptor signaling pathway
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Lien E, Ingalls RR (January 2002). "Toll-like receptors".
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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positive regulation of transcription by RNA polymerase II
1791:. In Greenwood D, Slack RC, Barer MR, Irving WL (eds.). 399: 919:
positive regulation of tumor necrosis factor production
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MyD88-independent toll-like receptor signaling pathway
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microglial cell activation involved in immune response
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positive regulation of type III interferon production
564: 4521: 4495: 4417: 4176: 3970: 3719: 3403: 3126: 2786: 2384: 1520:TLR3 displays a protective role in mouse models of 1282: 1261: 1227: 1206: 969:
positive regulation of type I interferon production
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TRIF-dependent toll-like receptor signaling pathway
1613: 1611: 1609: 1592: 1590: 1588: 804:negative regulation of osteoclast differentiation 749:positive regulation of interferon-beta production 346: 245: 1509:is also recognised by the cytoplasmic receptors 1493:, a form of genetic information carried by some 849:regulation of dendritic cell cytokine production 824:activation of NF-kappaB-inducing kinase activity 784:positive regulation of interleukin-12 production 1865: 1863: 1734:"Signaling to NF-kappaB by Toll-like receptors" 914:positive regulation of interleukin-6 production 904:positive regulation of interleukin-8 production 1618:GRCm38: Ensembl release 89: ENSMUSG00000031639 1014:positive regulation of NIK/NF-kappaB signaling 769:positive regulation of protein phosphorylation 4390: 2353: 2277: 8: 1727: 1725: 779:positive regulation of inflammatory response 1597:GRCh38: Ensembl release 89: ENSG00000164342 929:positive regulation of chemokine production 130:, CD283, IIAE2, toll like receptor 3, IMD83 4397: 4383: 4375: 2360: 2346: 2338: 2284: 2270: 2262: 2252:United States National Library of Medicine 1039: 809:positive regulation of cytokine production 599: 515:transitional epithelium of urinary bladder 387: 286: 183: 65: 2377:list of human clusters of differentiation 2230: 2187: 2054: 2005: 1956: 1946: 1897: 1887: 1749: 1705: 1695: 637:transmembrane signaling receptor activity 2250:This article incorporates text from the 934:positive regulation of apoptotic process 869:cellular response to mechanical stimulus 2299: 1584: 964:toll-like receptor 3 signaling pathway 879:positive regulation of gene expression 20: 1004:extrinsic apoptotic signaling pathway 924:cellular response to interferon-gamma 688:integral component of plasma membrane 351: 312: 307: 250: 209: 204: 7: 909:cellular response to exogenous dsRNA 859:toll-like receptor signaling pathway 794:cellular response to interferon-beta 519:vestibular membrane of cochlear duct 2211:CNS Neuroscience & Therapeutics 1986:CNS Neuroscience & Therapeutics 1774:"Entrez Gene: toll-like receptor 3" 1009:positive regulation of angiogenesis 959:I-kappaB kinase/NF-kappaB signaling 1732:Kawai T, Akira S (November 2007). 1411:. TLR3 recognizes double-stranded 1279: 1258: 1224: 1203: 1179: 1160: 1134: 1115: 1089: 1070: 834:positive regulation of JNK cascade 693:intracellular anatomical structure 569: 487: 425: 404: 14: 1392:that in humans is encoded by the 2317: 2302: 2147:10.1097/00003246-200201001-00001 1489:TLR3 recognizes double-stranded 573: 531:lumbar subsegment of spinal cord 335: 328: 322: 299: 234: 227: 221: 196: 29: 1419:, which is a common feature of 1534:The Scripps Research Institute 673:endoplasmic reticulum membrane 663:integral component of membrane 584:More reference expression data 553:More reference expression data 1: 1405:pattern recognition receptors 899:necroptotic signaling pathway 884:defense response to bacterium 523:vestibular sensory epithelium 320: 219: 1948:10.1371/journal.pone.0099526 1751:10.1016/j.molmed.2007.09.002 1738:Trends in Molecular Medicine 535:Epithelium of choroid plexus 4612:Clusters of differentiation 4607:Genes on human chromosome 4 2373:clusters of differentiation 1462:, and is restricted to the 994:apoptotic signaling pathway 799:response to exogenous dsRNA 642:signaling receptor activity 632:double-stranded RNA binding 4633: 2047:10.1016/j.stem.2015.07.008 1399:. TLR3 is a member of the 1386:cluster of differentiation 854:microglial cell activation 844:cellular response to dsRNA 477:pancreatic epithelial cell 2297: 1789:"Virus–Cell Interactions" 1653:"Mouse PubMed Reference:" 1635:"Human PubMed Reference:" 1360: 1355: 1351: 1344: 1328: 1315:Chr 4: 186.07 – 186.09 Mb 1309: 1286: 1265: 1254: 1231: 1210: 1199: 1186: 1182: 1167: 1163: 1154: 1141: 1137: 1122: 1118: 1109: 1096: 1092: 1077: 1073: 1064: 1049: 1042: 1038: 1022: 894:defense response to virus 622:identical protein binding 602: 598: 581: 572: 563: 550: 499: 490: 437: 428: 398: 390: 386: 369: 356: 319: 298: 289: 285: 268: 255: 218: 195: 186: 182: 137: 134: 124: 117: 112: 73: 68: 51: 46: 41: 37: 28: 23: 2180:10.4049/jimmunol.1303108 829:I-kappaB phosphorylation 2100:10.1126/science.1115253 1889:10.1073/pnas.1018515108 1540:molecules, making it a 1322:Chr 8: 45.85 – 45.86 Mb 16:Protein found in humans 2135:Critical Care Medicine 954:innate immune response 774:male gonad development 4523:Downstream signalling 2168:Journal of Immunology 1697:10.1073/pnas.95.2.588 1557:x-ray crystallography 1466:subpopulation of the 949:inflammatory response 839:hyperosmotic response 814:immune system process 718:endolysosome membrane 713:endoplasmic reticulum 445:palpebral conjunctiva 1793:Medical Microbiology 1409:innate immune system 1374:Toll-like receptor 3 733:extracellular matrix 314:Chromosome 8 (mouse) 212:Chromosome 4 (human) 69:List of PDB id codes 42:Available structures 4617:Toll-like receptors 2092:2005Sci...309..581C 1939:2014PLoSO...999526P 1830:2001Natur.413..732A 1688:1998PNAS...95..588R 1507:Double-stranded RNA 979:signal transduction 728:extracellular space 503:conjunctival fornix 473:epithelium of colon 2254:, which is in the 2141:(1 Suppl): S1-11. 1503:type I interferons 1401:toll-like receptor 1144:ENSMUSG00000031639 944:detection of virus 742:Biological process 703:lysosomal membrane 651:Cellular component 610:Molecular function 4594: 4593: 4412:signaling pathway 4406:Signaling pathway 4372: 4371: 2335: 2334: 2223:10.1111/cns.12469 2174:(10): 4783–4794. 2086:(5734): 581–585. 1998:10.1111/cns.12469 1824:(6857): 732–738. 1802:978-0-7020-4089-4 1787:Norval M (2012). 1371: 1370: 1367: 1366: 1340: 1339: 1305: 1304: 1276: 1275: 1250: 1249: 1221: 1220: 1195: 1194: 1176: 1175: 1150: 1149: 1131: 1130: 1105: 1104: 1086: 1085: 1034: 1033: 819:response to virus 754:response to dsRNA 723:endosome membrane 594: 593: 590: 589: 559: 558: 546: 545: 484: 483: 382: 381: 281: 280: 108: 107: 104: 103: 52:Ortholog search: 4624: 4399: 4392: 4385: 4376: 2362: 2355: 2348: 2339: 2321: 2306: 2286: 2279: 2272: 2263: 2244: 2234: 2201: 2191: 2158: 2120: 2119: 2075: 2069: 2068: 2058: 2026: 2020: 2019: 2009: 1977: 1971: 1970: 1960: 1950: 1918: 1912: 1911: 1901: 1891: 1882:(6): 2372–2377. 1867: 1858: 1857: 1838:10.1038/35099560 1813: 1807: 1806: 1784: 1778: 1777: 1770: 1764: 1763: 1753: 1729: 1720: 1719: 1709: 1699: 1667: 1661: 1660: 1649: 1643: 1642: 1631: 1625: 1615: 1604: 1594: 1551:Despite being a 1470:. It recognizes 1426:internalised by 1380:) also known as 1353: 1352: 1324: 1317: 1300: 1280: 1271: 1259: 1255:RefSeq (protein) 1245: 1225: 1216: 1204: 1180: 1161: 1135: 1116: 1090: 1071: 1040: 759:defense response 600: 586: 577: 570: 555: 527:secondary oocyte 511:stria vascularis 495: 493:Top expressed in 488: 433: 431:Top expressed in 426: 405: 388: 378: 365: 354: 339: 332: 326: 315: 303: 287: 277: 264: 253: 238: 231: 225: 214: 200: 184: 178: 176:TLR3 - orthologs 129: 122: 99: 66: 60: 39: 38: 33: 21: 4632: 4631: 4627: 4626: 4625: 4623: 4622: 4621: 4597: 4596: 4595: 4590: 4517: 4496:Other receptors 4491: 4413: 4403: 4373: 4368: 4172: 3966: 3715: 3399: 3122: 2782: 2380: 2366: 2336: 2331: 2328: 2322: 2313: 2307: 2293: 2290: 2247: 2217:(11): 905–913. 2204: 2161: 2132: 2128: 2126:Further reading 2123: 2077: 2076: 2072: 2028: 2027: 2023: 1992:(11): 905–913. 1979: 1978: 1974: 1920: 1919: 1915: 1869: 1868: 1861: 1815: 1814: 1810: 1803: 1786: 1785: 1781: 1772: 1771: 1767: 1744:(11): 460–469. 1731: 1730: 1723: 1669: 1668: 1664: 1651: 1650: 1646: 1633: 1632: 1628: 1616: 1607: 1595: 1586: 1582: 1565: 1530: 1522:atherosclerosis 1440: 1432:dendritic cells 1362:View/Edit Mouse 1357:View/Edit Human 1320: 1313: 1310:Location (UCSC) 1296: 1292: 1288: 1267: 1241: 1237: 1233: 1212: 1125:ENSG00000164342 1018: 737: 646: 617:protein binding 582: 551: 542: 537: 533: 529: 525: 521: 517: 513: 509: 505: 491: 480: 475: 471: 469:Achilles tendon 467: 463: 459: 455: 451: 447: 443: 429: 373: 360: 352: 342: 341: 340: 333: 313: 290:Gene location ( 272: 259: 251: 241: 240: 239: 232: 210: 187:Gene location ( 138: 125: 118: 75: 53: 17: 12: 11: 5: 4630: 4628: 4620: 4619: 4614: 4609: 4599: 4598: 4592: 4591: 4589: 4588: 4583: 4578: 4573: 4568: 4563: 4558: 4553: 4548: 4543: 4538: 4533: 4527: 4525: 4519: 4518: 4516: 4515: 4510: 4505: 4499: 4497: 4493: 4492: 4490: 4489: 4484: 4479: 4474: 4469: 4464: 4459: 4454: 4449: 4444: 4439: 4434: 4429: 4423: 4421: 4415: 4414: 4404: 4402: 4401: 4394: 4387: 4379: 4370: 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3595: 3594: 3589: 3584: 3574: 3569: 3564: 3559: 3554: 3553: 3552: 3547: 3537: 3532: 3527: 3522: 3517: 3512: 3507: 3506: 3505: 3500: 3490: 3484: 3479: 3474: 3469: 3460: 3455: 3454: 3453: 3448: 3443: 3433: 3428: 3423: 3418: 3413: 3407: 3405: 3401: 3400: 3398: 3397: 3392: 3387: 3382: 3377: 3372: 3367: 3362: 3357: 3352: 3347: 3342: 3337: 3332: 3327: 3322: 3317: 3312: 3307: 3302: 3297: 3292: 3287: 3282: 3277: 3272: 3271: 3270: 3265: 3255: 3254: 3253: 3248: 3238: 3233: 3228: 3223: 3218: 3213: 3208: 3203: 3198: 3193: 3188: 3183: 3178: 3177: 3176: 3171: 3161: 3156: 3151: 3146: 3141: 3136: 3130: 3128: 3124: 3123: 3121: 3120: 3115: 3110: 3105: 3100: 3095: 3090: 3085: 3080: 3071: 3066: 3061: 3056: 3051: 3046: 3045: 3044: 3039: 3034: 3029: 3024: 3019: 3009: 3004: 2999: 2994: 2989: 2984: 2983: 2982: 2977: 2967: 2962: 2957: 2952: 2947: 2942: 2937: 2932: 2927: 2926: 2925: 2920: 2915: 2910: 2905: 2900: 2890: 2889: 2888: 2883: 2878: 2868: 2863: 2862: 2861: 2856: 2851: 2841: 2836: 2831: 2826: 2821: 2816: 2811: 2806: 2801: 2796: 2790: 2788: 2784: 2783: 2781: 2780: 2775: 2774: 2773: 2768: 2763: 2758: 2753: 2748: 2738: 2733: 2728: 2723: 2718: 2713: 2708: 2707: 2706: 2701: 2696: 2691: 2681: 2676: 2671: 2666: 2661: 2656: 2651: 2646: 2641: 2636: 2635: 2634: 2629: 2619: 2614: 2609: 2604: 2599: 2594: 2589: 2584: 2579: 2574: 2569: 2564: 2559: 2554: 2549: 2548: 2547: 2542: 2532: 2527: 2522: 2517: 2516: 2515: 2510: 2505: 2500: 2490: 2485: 2480: 2479: 2478: 2468: 2463: 2458: 2453: 2448: 2447: 2446: 2441: 2436: 2426: 2421: 2420: 2419: 2414: 2409: 2404: 2399: 2388: 2386: 2382: 2381: 2367: 2365: 2364: 2357: 2350: 2342: 2333: 2332: 2330: 2329: 2323: 2316: 2314: 2308: 2301: 2298: 2295: 2294: 2291: 2289: 2288: 2281: 2274: 2266: 2246: 2245: 2202: 2159: 2129: 2127: 2124: 2122: 2121: 2070: 2041:(2): 139–151. 2035:Cell Stem Cell 2021: 1972: 1913: 1859: 1808: 1801: 1779: 1765: 1721: 1682:(2): 588–593. 1662: 1644: 1626: 1605: 1583: 1581: 1578: 1577: 1576: 1570: 1569: 1564: 1561: 1529: 1526: 1439: 1436: 1369: 1368: 1365: 1364: 1359: 1349: 1348: 1342: 1341: 1338: 1337: 1335: 1333: 1326: 1325: 1318: 1311: 1307: 1306: 1303: 1302: 1284: 1283: 1277: 1274: 1273: 1263: 1262: 1256: 1252: 1251: 1248: 1247: 1229: 1228: 1222: 1219: 1218: 1208: 1207: 1201: 1197: 1196: 1193: 1192: 1184: 1183: 1177: 1174: 1173: 1165: 1164: 1158: 1152: 1151: 1148: 1147: 1139: 1138: 1132: 1129: 1128: 1120: 1119: 1113: 1107: 1106: 1103: 1102: 1094: 1093: 1087: 1084: 1083: 1075: 1074: 1068: 1062: 1061: 1056: 1051: 1047: 1046: 1036: 1035: 1032: 1031: 1020: 1019: 1017: 1016: 1011: 1006: 1001: 996: 991: 986: 981: 976: 971: 966: 961: 956: 951: 946: 941: 936: 931: 926: 921: 916: 911: 906: 901: 896: 891: 886: 881: 876: 871: 866: 861: 856: 851: 846: 841: 836: 831: 826: 821: 816: 811: 806: 801: 796: 791: 786: 781: 776: 771: 766: 761: 756: 751: 745: 743: 739: 738: 736: 735: 730: 725: 720: 715: 710: 708:early endosome 705: 700: 695: 690: 685: 683:Golgi membrane 680: 675: 670: 665: 660: 654: 652: 648: 647: 645: 644: 639: 634: 629: 624: 619: 613: 611: 607: 606: 596: 595: 592: 591: 588: 587: 579: 578: 567: 561: 560: 557: 556: 548: 547: 544: 543: 541: 540: 536: 532: 528: 524: 520: 516: 512: 508: 504: 500: 497: 496: 485: 482: 481: 479: 478: 474: 470: 466: 462: 458: 454: 450: 446: 442: 441:jejunal mucosa 438: 435: 434: 422: 421: 413: 402: 396: 395: 392:RNA expression 384: 383: 380: 379: 371: 367: 366: 358: 355: 350: 344: 343: 334: 327: 321: 317: 316: 311: 305: 304: 296: 295: 283: 282: 279: 278: 270: 266: 265: 257: 254: 249: 243: 242: 233: 226: 220: 216: 215: 208: 202: 201: 193: 192: 180: 179: 136: 132: 131: 123: 115: 114: 110: 109: 106: 105: 102: 101: 71: 70: 62: 61: 50: 44: 43: 35: 34: 26: 25: 15: 13: 10: 9: 6: 4: 3: 2: 4629: 4618: 4615: 4613: 4610: 4608: 4605: 4604: 4602: 4587: 4584: 4582: 4579: 4577: 4574: 4572: 4569: 4567: 4564: 4562: 4559: 4557: 4554: 4552: 4549: 4547: 4544: 4542: 4539: 4537: 4534: 4532: 4529: 4528: 4526: 4524: 4520: 4514: 4511: 4509: 4506: 4504: 4501: 4500: 4498: 4494: 4488: 4485: 4483: 4480: 4478: 4475: 4473: 4470: 4468: 4465: 4463: 4460: 4458: 4455: 4453: 4450: 4448: 4445: 4443: 4440: 4438: 4435: 4433: 4430: 4428: 4425: 4424: 4422: 4420: 4416: 4411: 4407: 4400: 4395: 4393: 4388: 4386: 4381: 4380: 4377: 4365: 4362: 4360: 4357: 4355: 4352: 4350: 4347: 4345: 4342: 4340: 4337: 4335: 4332: 4330: 4327: 4325: 4322: 4320: 4317: 4315: 4312: 4310: 4307: 4305: 4302: 4300: 4297: 4295: 4292: 4290: 4287: 4285: 4282: 4280: 4277: 4275: 4272: 4270: 4267: 4265: 4262: 4260: 4257: 4255: 4252: 4250: 4247: 4245: 4242: 4240: 4237: 4235: 4232: 4230: 4227: 4225: 4222: 4220: 4217: 4215: 4212: 4210: 4207: 4205: 4202: 4200: 4197: 4195: 4192: 4190: 4187: 4185: 4182: 4181: 4179: 4175: 4169: 4166: 4164: 4161: 4159: 4156: 4154: 4151: 4149: 4146: 4144: 4141: 4139: 4136: 4134: 4131: 4129: 4126: 4124: 4121: 4119: 4116: 4114: 4111: 4109: 4106: 4104: 4101: 4099: 4096: 4094: 4091: 4089: 4086: 4084: 4081: 4079: 4076: 4074: 4071: 4069: 4066: 4064: 4061: 4059: 4056: 4054: 4051: 4049: 4046: 4044: 4041: 4039: 4036: 4034: 4031: 4029: 4026: 4024: 4021: 4019: 4016: 4014: 4011: 4009: 4006: 4004: 4001: 3999: 3996: 3994: 3991: 3989: 3986: 3984: 3981: 3979: 3976: 3975: 3973: 3969: 3963: 3960: 3958: 3954: 3951: 3949: 3946: 3944: 3941: 3939: 3936: 3934: 3931: 3929: 3926: 3924: 3921: 3919: 3916: 3914: 3911: 3909: 3906: 3902: 3899: 3897: 3894: 3893: 3892: 3889: 3887: 3884: 3882: 3879: 3877: 3874: 3872: 3869: 3867: 3864: 3862: 3859: 3857: 3854: 3852: 3849: 3847: 3844: 3842: 3839: 3837: 3834: 3832: 3829: 3827: 3824: 3821: 3818: 3816: 3812: 3809: 3807: 3804: 3800: 3797: 3795: 3792: 3791: 3790: 3787: 3785: 3782: 3778: 3775: 3773: 3770: 3769: 3768: 3765: 3763: 3760: 3758: 3755: 3753: 3750: 3748: 3745: 3743: 3740: 3738: 3735: 3733: 3730: 3728: 3725: 3724: 3722: 3718: 3712: 3709: 3707: 3704: 3702: 3699: 3697: 3694: 3692: 3689: 3687: 3684: 3682: 3679: 3677: 3674: 3672: 3669: 3667: 3664: 3662: 3659: 3657: 3654: 3652: 3649: 3647: 3644: 3642: 3639: 3637: 3634: 3632: 3629: 3625: 3622: 3620: 3617: 3616: 3615: 3612: 3610: 3607: 3605: 3602: 3600: 3597: 3593: 3590: 3588: 3585: 3583: 3580: 3579: 3578: 3575: 3573: 3570: 3568: 3565: 3563: 3560: 3558: 3555: 3551: 3548: 3546: 3543: 3542: 3541: 3538: 3536: 3533: 3531: 3528: 3526: 3523: 3521: 3518: 3516: 3513: 3511: 3508: 3504: 3501: 3499: 3496: 3495: 3494: 3491: 3488: 3485: 3483: 3480: 3478: 3475: 3473: 3470: 3468: 3464: 3461: 3459: 3456: 3452: 3449: 3447: 3444: 3442: 3439: 3438: 3437: 3434: 3432: 3429: 3427: 3424: 3422: 3419: 3417: 3414: 3412: 3409: 3408: 3406: 3402: 3396: 3393: 3391: 3388: 3386: 3383: 3381: 3378: 3376: 3373: 3371: 3368: 3366: 3363: 3361: 3358: 3356: 3353: 3351: 3348: 3346: 3343: 3341: 3338: 3336: 3333: 3331: 3328: 3326: 3323: 3321: 3318: 3316: 3313: 3311: 3308: 3306: 3303: 3301: 3298: 3296: 3293: 3291: 3288: 3286: 3283: 3281: 3278: 3276: 3273: 3269: 3266: 3264: 3261: 3260: 3259: 3256: 3252: 3249: 3247: 3244: 3243: 3242: 3239: 3237: 3234: 3232: 3229: 3227: 3224: 3222: 3219: 3217: 3214: 3212: 3209: 3207: 3204: 3202: 3199: 3197: 3194: 3192: 3189: 3187: 3184: 3182: 3179: 3175: 3172: 3170: 3167: 3166: 3165: 3162: 3160: 3157: 3155: 3152: 3150: 3147: 3145: 3142: 3140: 3137: 3135: 3132: 3131: 3129: 3125: 3119: 3116: 3114: 3111: 3109: 3106: 3104: 3101: 3099: 3096: 3094: 3091: 3089: 3086: 3084: 3081: 3079: 3075: 3072: 3070: 3067: 3065: 3062: 3060: 3057: 3055: 3052: 3050: 3047: 3043: 3040: 3038: 3035: 3033: 3030: 3028: 3025: 3023: 3020: 3018: 3015: 3014: 3013: 3010: 3008: 3005: 3003: 3000: 2998: 2995: 2993: 2990: 2988: 2985: 2981: 2978: 2976: 2973: 2972: 2971: 2968: 2966: 2963: 2961: 2958: 2956: 2953: 2951: 2948: 2946: 2943: 2941: 2938: 2936: 2933: 2931: 2928: 2924: 2921: 2919: 2916: 2914: 2911: 2909: 2906: 2904: 2901: 2899: 2896: 2895: 2894: 2891: 2887: 2884: 2882: 2879: 2877: 2874: 2873: 2872: 2869: 2867: 2864: 2860: 2857: 2855: 2852: 2850: 2847: 2846: 2845: 2842: 2840: 2837: 2835: 2832: 2830: 2827: 2825: 2822: 2820: 2817: 2815: 2812: 2810: 2807: 2805: 2802: 2800: 2797: 2795: 2792: 2791: 2789: 2785: 2779: 2776: 2772: 2769: 2767: 2764: 2762: 2759: 2757: 2754: 2752: 2749: 2747: 2744: 2743: 2742: 2739: 2737: 2734: 2732: 2729: 2727: 2724: 2722: 2719: 2717: 2714: 2712: 2709: 2705: 2702: 2700: 2697: 2695: 2692: 2690: 2687: 2686: 2685: 2682: 2680: 2677: 2675: 2672: 2670: 2667: 2665: 2662: 2660: 2657: 2655: 2652: 2650: 2647: 2645: 2642: 2640: 2637: 2633: 2630: 2628: 2625: 2624: 2623: 2620: 2618: 2615: 2613: 2610: 2608: 2605: 2603: 2600: 2598: 2595: 2593: 2590: 2588: 2585: 2583: 2580: 2578: 2575: 2573: 2570: 2568: 2565: 2563: 2560: 2558: 2555: 2553: 2550: 2546: 2543: 2541: 2538: 2537: 2536: 2533: 2531: 2528: 2526: 2523: 2521: 2518: 2514: 2511: 2509: 2506: 2504: 2501: 2499: 2496: 2495: 2494: 2491: 2489: 2486: 2484: 2481: 2477: 2474: 2473: 2472: 2469: 2467: 2464: 2462: 2459: 2457: 2454: 2452: 2449: 2445: 2442: 2440: 2437: 2435: 2432: 2431: 2430: 2427: 2425: 2422: 2418: 2415: 2413: 2410: 2408: 2405: 2403: 2400: 2398: 2395: 2394: 2393: 2390: 2389: 2387: 2383: 2378: 2374: 2370: 2363: 2358: 2356: 2351: 2349: 2344: 2343: 2340: 2326: 2320: 2315: 2311: 2305: 2300: 2296: 2287: 2282: 2280: 2275: 2273: 2268: 2267: 2264: 2260: 2259: 2257: 2256:public domain 2253: 2242: 2238: 2233: 2228: 2224: 2220: 2216: 2212: 2208: 2203: 2199: 2195: 2190: 2185: 2181: 2177: 2173: 2169: 2165: 2160: 2156: 2152: 2148: 2144: 2140: 2136: 2131: 2130: 2125: 2117: 2113: 2109: 2105: 2101: 2097: 2093: 2089: 2085: 2081: 2074: 2071: 2066: 2062: 2057: 2052: 2048: 2044: 2040: 2036: 2032: 2025: 2022: 2017: 2013: 2008: 2003: 1999: 1995: 1991: 1987: 1983: 1976: 1973: 1968: 1964: 1959: 1954: 1949: 1944: 1940: 1936: 1933:(6): e99526. 1932: 1928: 1924: 1917: 1914: 1909: 1905: 1900: 1895: 1890: 1885: 1881: 1877: 1873: 1866: 1864: 1860: 1855: 1851: 1847: 1843: 1839: 1835: 1831: 1827: 1823: 1819: 1812: 1809: 1804: 1798: 1794: 1790: 1783: 1780: 1775: 1769: 1766: 1761: 1757: 1752: 1747: 1743: 1739: 1735: 1728: 1726: 1722: 1717: 1713: 1708: 1703: 1698: 1693: 1689: 1685: 1681: 1677: 1673: 1666: 1663: 1658: 1654: 1648: 1645: 1640: 1636: 1630: 1627: 1623: 1619: 1614: 1612: 1610: 1606: 1602: 1598: 1593: 1591: 1589: 1585: 1579: 1575: 1572: 1571: 1567: 1566: 1562: 1560: 1558: 1554: 1549: 1547: 1543: 1539: 1535: 1527: 1525: 1523: 1518: 1516: 1512: 1508: 1504: 1500: 1496: 1492: 1487: 1485: 1481: 1477: 1473: 1469: 1465: 1461: 1457: 1453: 1449: 1445: 1437: 1435: 1433: 1429: 1425: 1422: 1418: 1414: 1410: 1406: 1402: 1398: 1395: 1391: 1387: 1383: 1379: 1375: 1363: 1358: 1354: 1350: 1347: 1343: 1336: 1334: 1331: 1327: 1323: 1319: 1316: 1312: 1308: 1301: 1299: 1295: 1291: 1285: 1281: 1278: 1272: 1270: 1264: 1260: 1257: 1253: 1246: 1244: 1240: 1236: 1230: 1226: 1223: 1217: 1215: 1209: 1205: 1202: 1200:RefSeq (mRNA) 1198: 1191: 1190: 1185: 1181: 1178: 1172: 1171: 1166: 1162: 1159: 1157: 1153: 1146: 1145: 1140: 1136: 1133: 1127: 1126: 1121: 1117: 1114: 1112: 1108: 1101: 1100: 1095: 1091: 1088: 1082: 1081: 1076: 1072: 1069: 1067: 1063: 1060: 1057: 1055: 1052: 1048: 1045: 1041: 1037: 1030: 1026: 1021: 1015: 1012: 1010: 1007: 1005: 1002: 1000: 997: 995: 992: 990: 987: 985: 982: 980: 977: 975: 972: 970: 967: 965: 962: 960: 957: 955: 952: 950: 947: 945: 942: 940: 937: 935: 932: 930: 927: 925: 922: 920: 917: 915: 912: 910: 907: 905: 902: 900: 897: 895: 892: 890: 887: 885: 882: 880: 877: 875: 872: 870: 867: 865: 862: 860: 857: 855: 852: 850: 847: 845: 842: 840: 837: 835: 832: 830: 827: 825: 822: 820: 817: 815: 812: 810: 807: 805: 802: 800: 797: 795: 792: 790: 787: 785: 782: 780: 777: 775: 772: 770: 767: 765: 762: 760: 757: 755: 752: 750: 747: 746: 744: 741: 740: 734: 731: 729: 726: 724: 721: 719: 716: 714: 711: 709: 706: 704: 701: 699: 696: 694: 691: 689: 686: 684: 681: 679: 676: 674: 671: 669: 666: 664: 661: 659: 656: 655: 653: 650: 649: 643: 640: 638: 635: 633: 630: 628: 625: 623: 620: 618: 615: 614: 612: 609: 608: 605: 604:Gene ontology 601: 597: 585: 580: 576: 571: 568: 566: 562: 554: 549: 538: 534: 530: 526: 522: 518: 514: 510: 506: 502: 501: 498: 494: 489: 486: 476: 472: 468: 464: 460: 456: 452: 448: 444: 440: 439: 436: 432: 427: 424: 423: 420: 418: 414: 412: 411: 407: 406: 403: 401: 397: 393: 389: 385: 377: 372: 368: 364: 359: 353:8|8 B1.1 349: 345: 338: 331: 325: 318: 310: 306: 302: 297: 293: 288: 284: 276: 271: 267: 263: 258: 248: 244: 237: 230: 224: 217: 213: 207: 203: 199: 194: 190: 185: 181: 177: 173: 169: 165: 161: 157: 153: 149: 145: 141: 133: 128: 121: 116: 111: 100: 98: 94: 90: 86: 82: 78: 72: 67: 64: 63: 59: 56: 49: 45: 40: 36: 32: 27: 22: 19: 4436: 3890: 3810: 3788: 3766: 3613: 3576: 3539: 3492: 3462: 3435: 3257: 3163: 3011: 2740: 2492: 2324: 2309: 2249: 2248: 2214: 2210: 2171: 2167: 2138: 2134: 2083: 2079: 2073: 2038: 2034: 2024: 1989: 1985: 1975: 1930: 1926: 1916: 1879: 1875: 1821: 1817: 1811: 1792: 1782: 1768: 1741: 1737: 1679: 1675: 1665: 1656: 1647: 1638: 1629: 1553:glycoprotein 1550: 1542:glycoprotein 1531: 1519: 1488: 1443: 1441: 1393: 1381: 1377: 1373: 1372: 1298:NP_001344246 1294:NP_001344245 1287: 1266: 1243:NM_001357317 1239:NM_001357316 1232: 1211: 1187: 1168: 1142: 1123: 1097: 1078: 1058: 1053: 698:cell surface 415: 408: 273:186,088,073 260:186,069,155 135:External IDs 74: 18: 2292:PDB gallery 1568:Antagonists 1546:amino acids 1484:interferons 1428:macrophages 989:necroptosis 627:RNA binding 465:gallbladder 374:45,864,117 361:45,848,702 113:Identifiers 4601:Categories 2375:(see also 1624:, May 2017 1603:, May 2017 1580:References 1499:reoviruses 1468:leukocytes 1444:Drosophila 1403:family of 1388:283) is a 419:(ortholog) 156:HomoloGene 1528:Structure 1464:dendritic 1452:cytokines 1417:endosomes 1290:NP_569054 1269:NP_003256 1235:NM_126166 1214:NM_003265 1044:Orthologs 658:cytoplasm 164:GeneCards 2369:Proteins 2241:26494128 2198:24729619 2155:11782555 2108:15961631 2065:26253200 2016:26494128 1967:24914679 1927:PLOS ONE 1908:21220319 1846:11607032 1760:18029230 1620:– 1599:– 1574:CU-CPT4a 1497:such as 1460:pancreas 1456:placenta 1438:Function 1346:Wikidata 1023:Sources: 678:membrane 668:endosome 507:gastrula 461:duodenum 449:placenta 4177:301–350 3971:251–300 3923:CD240CE 3720:201–250 3404:151–200 3127:101–150 2232:4638223 2189:4009499 2116:4962727 2088:Bibcode 2080:Science 2056:4529957 2007:4638223 1958:4051824 1935:Bibcode 1899:3038746 1854:4346537 1826:Bibcode 1716:9435236 1684:Bibcode 1622:Ensembl 1601:Ensembl 1563:Ligands 1495:viruses 1424:genomes 1407:of the 1390:protein 1156:UniProt 1111:Ensembl 1050:Species 1029:QuickGO 539:jejunum 394:pattern 152:2156367 120:Aliases 4581:TOLLIP 4571:TICAM1 4556:MAP3K7 4184:CD300A 4143:CDw293 3928:CD240D 3789:CD213a 3767:CDw210 3732:CD202b 3706:CDw199 3701:CDw198 3355:CD140b 2787:51–100 2239:  2229:  2196:  2186:  2153:  2114:  2106:  2063:  2053:  2014:  2004:  1965:  1955:  1906:  1896:  1852:  1844:  1818:Nature 1799:  1758:  1714:  1704:  1332:search 1330:PubMed 1189:Q99MB1 1170:O15455 1099:142980 1066:Entrez 565:BioGPS 453:rectum 252:4q35.1 144:603029 4586:TRAF6 4576:TIRAP 4561:MYD88 4546:IRAK4 4541:IRAK3 4536:IRAK2 4531:IRAK1 4487:TLR13 4482:TLR12 4477:TLR11 4472:TLR10 4364:CD350 4359:CD349 4354:CD344 4349:CD340 4344:CD339 4339:CD338 4334:CD337 4329:CD336 4324:CD335 4319:CD334 4314:CD333 4309:CD332 4304:CD331 4299:CD329 4294:CD328 4289:CD327 4284:CD326 4279:CD325 4274:CD324 4269:CD322 4264:CD321 4259:CD320 4254:CD318 4249:CD317 4244:CD316 4239:CD315 4234:CD314 4229:CD312 4224:CD309 4219:CD307 4214:CD306 4209:CD305 4204:CD304 4199:CD303 4194:CD302 4189:CD301 4168:CD299 4163:CD298 4158:CD297 4153:CD295 4148:CD294 4138:CD292 4133:CD290 4128:CD289 4123:CD288 4118:CD286 4113:CD284 4108:CD283 4103:CD282 4098:CD281 4093:CD280 4088:CD279 4083:CD278 4078:CD276 4073:CD275 4068:CD274 4063:CD273 4058:CD272 4053:CD271 4048:CD269 4043:CD268 4038:CD267 4033:CD266 4028:CD265 4023:CD264 4018:CD263 4013:CD262 4008:CD261 4003:CD258 3998:CD257 3993:CD256 3988:CD254 3983:CD253 3978:CD252 3962:CD249 3957:CD248 3953:CD247 3948:CD246 3943:CD244 3938:CD243 3933:CD241 3918:CD239 3913:CD238 3908:CD236 3891:CD235 3886:CD234 3881:CD233 3876:CD230 3871:CD229 3866:CD228 3861:CD227 3856:CD226 3851:CD225 3846:CD224 3841:CD223 3836:CD222 3831:CD221 3826:CD220 3811:CD218 3806:CD217 3784:CD212 3762:CD209 3757:CD208 3752:CD207 3747:CD206 3742:CD205 3737:CD204 3727:CD201 3711:CD200 3696:CD197 3691:CD196 3686:CD195 3681:CD194 3676:CD193 3671:CD192 3666:CD191 3661:CD186 3656:CD185 3651:CD184 3646:CD183 3641:CD182 3636:CD181 3631:CD180 3614:CD179 3609:CD178 3604:CD177 3599:CD174 3577:CD172 3572:CD171 3567:CD170 3562:CD169 3557:CD168 3540:CD167 3535:CD166 3530:CD164 3525:CD163 3520:CD162 3515:CD161 3510:CD160 3493:CD159 3463:CD158 3458:CD157 3436:CD156 3431:CD155 3426:CD154 3421:CD153 3416:CD152 3411:CD151 3395:CD150 3390:CD148 3385:CD147 3380:CD146 3375:CD144 3370:CD143 3365:CD142 3360:CD141 3350:CD138 3345:CD137 3340:CD136 3335:CD135 3330:CD134 3325:CD133 3320:CD132 3315:CD131 3310:CD130 3305:CD129 3300:CD127 3295:CD126 3290:CD125 3285:CD124 3280:CD123 3275:CD122 3258:CD121 3241:CD120 3236:CD119 3231:CD118 3226:CD117 3221:CD116 3216:CD115 3211:CD114 3206:CD113 3201:CD112 3196:CD111 3191:CD110 3186:CD109 3181:CD108 3164:CD107 3159:CD106 3154:CD105 3149:CD104 3144:CD103 3139:CD102 3134:CD101 3118:CD100 2112:S2CID 1850:S2CID 1707:18464 1538:sugar 1515:MDA-5 1511:RIG-I 1480:NF-ÎșB 1472:dsRNA 1448:PAMPs 1421:viral 1382:CD283 1059:Mouse 1054:Human 1025:Amigo 457:sperm 417:Mouse 410:Human 357:Start 292:Mouse 256:Start 189:Human 160:20696 4566:TAB1 4551:IRF3 4503:CD14 4467:TLR9 4462:TLR8 4457:TLR7 4452:TLR6 4447:TLR5 4442:TLR4 4437:TLR3 4432:TLR2 4427:TLR1 4419:TLRs 3113:CD99 3108:CD98 3103:CD97 3098:CD96 3093:CD95 3088:CD94 3083:CD93 3078:CD92 3074:CD91 3069:CD90 3064:CD89 3059:CD88 3054:CD87 3049:CD86 3012:CD85 3007:CD84 3002:CD83 2997:CD82 2992:CD81 2987:CD80 2970:CD79 2965:CD78 2960:CD74 2955:CD73 2950:CD72 2945:CD71 2940:CD70 2935:CD69 2930:CD68 2893:CD66 2871:CD64 2866:CD63 2844:CD62 2839:CD61 2834:CD59 2829:CD58 2824:CD57 2819:CD56 2814:CD55 2809:CD54 2804:CD53 2799:CD52 2794:CD51 2778:CD50 2741:CD49 2736:CD48 2731:CD47 2726:CD46 2721:CD45 2716:CD44 2711:CD43 2684:CD42 2679:CD41 2674:CD40 2669:CD39 2664:CD38 2659:CD37 2654:CD36 2649:CD35 2644:CD34 2639:CD33 2622:CD32 2617:CD31 2612:CD30 2607:CD29 2602:CD28 2597:CD27 2592:CD26 2587:CD25 2582:CD24 2577:CD23 2572:CD22 2567:CD21 2562:CD20 2557:CD19 2552:CD18 2535:CD16 2530:CD15 2525:CD14 2520:CD13 2493:CD11 2488:CD10 2385:1–50 2325:2a0z 2310:1ziw 2237:PMID 2194:PMID 2151:PMID 2104:PMID 2061:PMID 2012:PMID 1963:PMID 1904:PMID 1842:PMID 1797:ISBN 1756:PMID 1712:PMID 1513:and 1478:and 1476:IRF3 1458:and 1430:and 1397:gene 1394:TLR3 1378:TLR3 1080:7098 400:Bgee 348:Band 309:Chr. 247:Band 206:Chr. 168:TLR3 140:OMIM 127:TLR3 97:2MKA 93:2MK9 89:3ULV 85:3ULU 81:2A0Z 77:1ZIW 58:RCSB 55:PDBe 24:TLR3 4513:MD2 4508:LBP 4410:TLR 2483:CD9 2471:CD8 2466:CD7 2461:CD6 2456:CD5 2451:CD4 2429:CD3 2424:CD2 2397:a-c 2392:CD1 2227:PMC 2219:doi 2184:PMC 2176:doi 2172:192 2143:doi 2096:doi 2084:309 2051:PMC 2043:doi 2002:PMC 1994:doi 1953:PMC 1943:doi 1894:PMC 1884:doi 1880:108 1834:doi 1822:413 1746:doi 1702:PMC 1692:doi 1491:RNA 1415:in 1413:RNA 370:End 269:End 172:OMA 148:MGI 48:PDB 4603:: 4408:: 3955:- 3076:- 2417:1E 2412:1D 2407:1B 2402:1A 2371:: 2235:. 2225:. 2215:21 2213:. 2209:. 2192:. 2182:. 2170:. 2166:. 2149:. 2139:30 2137:. 2110:. 2102:. 2094:. 2082:. 2059:. 2049:. 2039:17 2037:. 2033:. 2010:. 2000:. 1990:21 1988:. 1984:. 1961:. 1951:. 1941:. 1929:. 1925:. 1902:. 1892:. 1878:. 1874:. 1862:^ 1848:. 1840:. 1832:. 1820:. 1754:. 1742:13 1740:. 1736:. 1724:^ 1710:. 1700:. 1690:. 1680:95 1678:. 1674:. 1655:. 1637:. 1608:^ 1587:^ 1559:. 1517:. 1434:. 1027:/ 376:bp 363:bp 275:bp 262:bp 170:; 166:: 162:; 158:: 154:; 150:: 146:; 142:: 95:, 91:, 87:, 83:, 79:, 4398:e 4391:t 4384:v 3901:b 3896:a 3822:) 3820:b 3815:a 3813:( 3799:2 3794:1 3777:b 3772:a 3624:b 3619:a 3592:g 3587:b 3582:a 3550:b 3545:a 3503:c 3498:a 3489:) 3487:k 3482:i 3477:e 3472:d 3467:a 3465:( 3451:c 3446:b 3441:a 3268:b 3263:a 3251:b 3246:a 3174:b 3169:a 3042:k 3037:j 3032:h 3027:e 3022:d 3017:a 2980:b 2975:a 2923:f 2918:e 2913:d 2908:c 2903:b 2898:a 2886:C 2881:B 2876:A 2859:P 2854:L 2849:E 2771:f 2766:e 2761:d 2756:c 2751:b 2746:a 2704:d 2699:c 2694:b 2689:a 2632:B 2627:A 2545:B 2540:A 2513:d 2508:c 2503:b 2498:a 2476:a 2444:Δ 2439:ÎŽ 2434:Îł 2379:) 2361:e 2354:t 2347:v 2285:e 2278:t 2271:v 2258:. 2243:. 2221:: 2200:. 2178:: 2157:. 2145:: 2118:. 2098:: 2090:: 2067:. 2045:: 2018:. 1996:: 1969:. 1945:: 1937:: 1931:9 1910:. 1886:: 1856:. 1836:: 1828:: 1805:. 1776:. 1762:. 1748:: 1718:. 1694:: 1686:: 1659:. 1641:. 1384:( 1376:( 294:) 191:) 174::

Index


PDB
PDBe
RCSB
1ZIW
2A0Z
3ULU
3ULV
2MK9
2MKA
Aliases
TLR3
OMIM
603029
MGI
2156367
HomoloGene
20696
GeneCards
TLR3
OMA
TLR3 - orthologs
Human
Chromosome 4 (human)
Chr.
Chromosome 4 (human)
Chromosome 4 (human)
Genomic location for TLR3
Genomic location for TLR3
Band

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