343:
320:
217:
242:
2802:
2877:
2832:
2817:
608:
601:
2862:
2847:
1354:
594:
349:
248:
42:
1345:
motifs. EGFR is essential for a single transmembrane domain, an intracellular domain (containing tyrosine kinase activity), and ligand recognition. As a membrane anchored-growth factor, TGF-α can be cleaved from an integral membrane glycoprotein via a protease. Soluble forms of TGF-α resulting from
1269:
TGF-α is synthesized internally as part of a 160 (human) or 159 (rat) amino acid transmembrane precursor. The precursor is composed of an extracellular domain containing a hydrophobic transmembrane domain, 50 amino acids of TGF-α, and a 35-residue-long cytoplasmic domain. In its smallest form, TGF-α
1305:
development. Considering that TGF-α is a member of the EGF family, the biological actions of TGF-α and EGF are similar. For instance, TGF-α and EGF bind to the same receptor. When TGF-α binds to EGFR it can initiate multiple cell proliferation events. Cell proliferation events that involve TGF-α
1895:
Fanelli MF, Chinen LT, Begnami MD, Costa WL, Fregnami JH, Soares FA, et al. (August 2012). "The influence of transforming growth factor-α, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients
1407:
TGF-α has also been observed to be highly expressed in the suprachiasmatic nucleus (SCN) (5). This finding suggests a role for EGFR signaling in the regulation of CLOCK and circadian rhythms within the SCN. Similar studies have shown that when injected into the third ventricle TGF-α can suppress
1349:
When TGF-α binds to EGFR it dimerizes triggering phosphorylation of a protein-tyrosine kinase. The activity of protein-tyrosine kinase causes an autophosphorylation to occur among several tyrosine residues within EGFR, influencing activation and signaling of other proteins that interact in many
1257:, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of
68:
1398:
through a glial-neuronal interactive process. Produced in hypothalamic astrocytes, TGF-α indirectly stimulates LHRH release through various intermediates. As a result, TGF-α is a physiological component essential to the initiation process of female puberty.
1631:
Ferrer I, Alcántara S, Ballabriga J, Olivé M, Blanco R, Rivera R, et al. (June 1996). "Transforming growth factor-alpha (TGF-alpha) and epidermal growth factor-receptor (EGF-R) immunoreactivity in normal and pathologic brain".
2666:"Transforming growth factor-alpha (TGF-alpha) in human bone marrow: demonstration of TGF-alpha in erythroblasts and eosinophilic precursor cells and of epidermal growth factor receptors in blastlike cells of myelomonocytic origin"
1810:"Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons"
2189:
Nasim MM, Thomas DM, Alison MR, Filipe MI (April 1992). "Transforming growth factor alpha expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma--an immunohistochemical study".
2328:
Werner S, Roth WK, Bates B, Goldfarb M, Hofschneider PH (November 1991). "Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors".
1270:
has six cysteines linked together via three disulfide bridges. Collectively, all members of the EGF/TGF-α family share this structure. The protein, however, is not directly related to TGF-β.
3407:
2801:
1672:"Structure-based minimization of transforming growth factor-alpha (TGF-alpha) through NMR analysis of the receptor-bound ligand. Design, solution structure, and activity of TGF-alpha 8-50"
1381:, infusion of TGF-α into the brain caused an increase in the number of neuronal precursor cells. However TGF-α treatment did not result in neurogenesis of dopaminergic neurons.
2876:
2831:
2816:
2299:
Lei ZM, Rao CV (August 1992). "Expression of epidermal growth factor (EGF) receptor and its ligands, EGF and transforming growth factor-alpha, in human fallopian tubes".
2270:
Bean MF, Carr SA (March 1992). "Characterization of disulfide bond position in proteins and sequence analysis of cystine-bridged peptides by tandem mass spectrometry".
356:
255:
2643:
Ogbureke KU, MacDaniel RK, Jacob RS, Durban EM (July 1995). "Distribution of immunoreactive transforming growth factor-alpha in non-neoplastic human salivary glands".
5322:
2419:
Kline TP, Brown FK, Brown SC, Jeffs PW, Kopple KD, Mueller L (August 1990). "Solution structures of human transforming growth factor alpha derived from 1H NMR data".
3400:
6282:
2606:
Derynck R, Roberts AB, Winkler ME, Chen EY, Goeddel DV (August 1984). "Human transforming growth factor-alpha: precursor structure and expression in E. coli".
2526:
Tricoli JV, Nakai H, Byers MG, Rall LB, Bell GI, Shows TB (1986). "The gene for human transforming growth factor alpha is on the short arm of chromosome 2".
1581:
Ojeda SR, Ma YJ, Rage F (September 1997). "The transforming growth factor alpha gene family is involved in the neuroendocrine control of mammalian puberty".
2701:"Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathy"
5938:
5086:
6332:
4703:
3393:
2861:
2846:
2096:
Luetteke NC, Lee DC (August 1990). "Transforming growth factor alpha: expression, regulation and biological action of its integral membrane precursor".
921:
902:
178:
4761:
5623:
5313:
2917:
4918:
3903:
3586:
3142:
6301:
6251:
6222:
6169:
4656:
4523:
2781:
1537:
2117:
Greten FR, Wagner M, Weber CK, Zechner U, Adler G, Schmid RM (2002). "TGF alpha transgenic mice. A model of pancreatic cancer development".
1519:
6352:
5980:
5976:
5972:
5968:
3521:
3505:
3343:
3338:
3333:
2485:"The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence"
1711:
Coffey RJ, Gangarosa LM, Damstrup L, Dempsey PJ (October 1995). "Basic actions of transforming growth factor-alpha and related peptides".
4249:
4168:
4035:
3952:
342:
5964:
3325:
1306:
bound to EGFR include wound healing and embryogenesis. TGF-α is also involved in tumerogenesis and believed to promote angiogenesis.
1273:
Limited success has resulted from attempts to synthesize of a reductant molecule to TGF-α that displays a similar biological profile.
1941:"A four-marker signature of TNF-RII, TGF-α, TIMP-1 and CRP is prognostic of worse survival in high-risk surgically resected melanoma"
1149:
5653:
4772:
4332:
3943:
2945:
1156:
319:
1751:"In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain"
3601:
3545:
3536:
1558:
1357:
1341:
to function in various signaling pathways. The EGF receptor is characterized by having an extracellular domain that has numerous
1254:
1281:
In the stomach, TGF-α is manufactured within the normal gastric mucosa. TGF-α has been shown to inhibit gastric acid secretion.
6175:
3231:
3160:
1506:
1485:
6262:
6238:
5378:
4934:
4797:
3292:
2960:
1860:
Hao H, Schwaber J (May 2006). "Epidermal growth factor receptor induced Erk phosphorylation in the suprachiasmatic nucleus".
1395:
1502:
241:
216:
65:
6228:
1481:
6272:
4668:
4550:
4540:
3219:
3214:
2910:
158:
1425:
1346:
the cleavage have the capacity to activate EGFR. EGFR can be activated from a membrane-anchored growth factor as well.
5618:
3348:
3110:
1437:
5643:
355:
254:
6257:
4083:
3204:
3187:
3152:
2989:
1457:
1258:
1246:
5638:
2044:"Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus"
6165:
2774:
348:
247:
4349:
4265:
4184:
4051:
3968:
3374:
2934:
2753:
2450:"A novel low molecular weight ribonucleic acid (RNA) related to transforming growth factor alpha messenger RNA"
966:
166:
3783:
5949:
3696:
3571:
3353:
3137:
2903:
2749:
1224:
947:
5628:
2156:"Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE review"
6233:
5849:
5753:
5613:
5373:
4792:
3778:
3416:
1370:
6307:
4504:
4148:
3788:
3427:
2810:: Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha
1250:
6247:
5633:
4565:
4514:
2767:
2568:
1762:
230:
145:
5383:
3458:
2351:"Regulation by estrogen through the 5'-flanking region of the transforming growth factor alpha gene"
1992:"Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach"
5388:
4802:
4499:
3691:
3369:
1374:
1132:
1103:
1099:
1095:
1044:
1040:
1036:
4424:
6006:
5919:
5864:
5818:
5763:
5498:
5438:
5066:
4439:
4369:
3928:
3526:
3468:
3419:
2682:
2665:
2631:
2594:
2229:"Immunoreactivity of transforming growth factor alpha in the normal adult gastrointestinal tract"
2215:
2142:
1921:
1606:
190:
6001:
5879:
5778:
5564:
5453:
5253:
5213:
4961:
4880:
4742:
4683:
4645:
4590:
4585:
4575:
4449:
4444:
4414:
4389:
4384:
4374:
4260:
4179:
4118:
4046:
4025:
4010:
3963:
3616:
1128:
1107:
1069:
1048:
6101:
5959:
5894:
5874:
5793:
5773:
5488:
5468:
5448:
5091:
4419:
4143:
3676:
3473:
5924:
5914:
5869:
5823:
5813:
5768:
5693:
5592:
5559:
5539:
5503:
5493:
5443:
5403:
4875:
4855:
4822:
4605:
4454:
2730:
2687:
2652:
2623:
2586:
2543:
2514:
2471:
2436:
2407:
2372:
2337:
2316:
2287:
2258:
2207:
2177:
2134:
2105:
2073:
2021:
1972:
1913:
1877:
1839:
1790:
1728:
1693:
1649:
1598:
1417:
1378:
138:
58:
5884:
5783:
5678:
5582:
5534:
5527:
5513:
5458:
5428:
4908:
4898:
4850:
4832:
4595:
4434:
4379:
6111:
5243:
2720:
2712:
2677:
2615:
2576:
2535:
2504:
2496:
2461:
2428:
2397:
2362:
2349:
Saeki T, Cristiano A, Lynch MJ, Brattain M, Kim N, Normanno N, et al. (December 1991).
2308:
2279:
2248:
2240:
2199:
2167:
2126:
2063:
2055:
2011:
2003:
1962:
1952:
1905:
1869:
1829:
1821:
1780:
1770:
1720:
1683:
1670:
McInnes C, Wang J, Al
Moustafa AE, Yansouni C, O'Connor-McCourt M, Sykes BD (October 1998).
1641:
1590:
607:
600:
435:
366:
310:
265:
17:
4635:
1939:
Tarhini AA, Lin Y, Yeku O, LaFramboise WA, Ashraf M, Sander C, et al. (January 2014).
5723:
3271:
3266:
3124:
1228:
593:
410:
186:
2885:: SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DERIVED FROM 1*H NMR DATA
2840:: TYPE ALPHA TRANSFORMING GROWTH FACTOR, NMR, 15 MODELS AFTER ECEPP/3 ENERGY MINIMIZATION
2572:
1766:
6297:
6218:
6160:
5854:
5703:
5698:
4812:
4807:
3453:
3443:
3438:
2402:
2385:
2253:
2228:
2203:
2068:
2043:
2016:
1991:
1967:
1940:
1834:
1809:
1749:
Fallon J, Reid S, Kinyamu R, Opole I, Opole R, Baratta J, et al. (December 2000).
1353:
2725:
2700:
2509:
2484:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
659:
654:
649:
41:
6346:
6336:
5991:
5904:
5833:
5803:
5738:
5648:
5602:
5478:
5408:
5353:
5342:
4827:
4535:
4218:
4123:
4015:
2926:
2619:
2283:
1909:
1785:
1750:
1724:
1645:
636:
3385:
2635:
2219:
2146:
1610:
6317:
6287:
6026:
6016:
5909:
5808:
5663:
5483:
5418:
5333:
4837:
4640:
4479:
4474:
4394:
4344:
4158:
3912:
3893:
3872:
3843:
3566:
3561:
2825:: TYPE ALPHA TRANSFORMING GROWTH FACTOR, NMR, 16 MODELS WITHOUT ENERGY MINIMIZATION
2598:
1925:
1873:
1825:
1416:
This protein shows potential use as a prognostic biomarker in various tumors, like
1298:
428:
207:
2557:"Cloning and sequence analysis of a cDNA for rat transforming growth factor-alpha"
170:
2699:
Patel B, Hiscott P, Charteris D, Mather J, McLeod D, Boulton M (September 1994).
194:
6277:
6243:
6141:
6131:
6126:
6116:
6066:
5889:
5788:
5549:
5463:
5393:
5288:
5051:
5016:
4966:
4929:
4865:
4747:
4678:
4630:
4620:
4615:
4610:
4494:
4489:
4484:
3862:
3773:
3763:
3731:
3726:
3721:
3716:
3706:
3666:
3631:
1542:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1524:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1338:
1314:
1294:
1290:
1235:
2483:
Jakobovits EB, Schlokat U, Vannice JL, Derynck R, Levinson AD (December 1988).
2312:
1755:
Proceedings of the
National Academy of Sciences of the United States of America
511:
6096:
6061:
6056:
6046:
6036:
5954:
5743:
5718:
5708:
5554:
5508:
5368:
5194:
5163:
5132:
5101:
5046:
5021:
5001:
4986:
4976:
4870:
4787:
4580:
4560:
4459:
4404:
4399:
4223:
4128:
4113:
3908:
3867:
3839:
3808:
3768:
3671:
3626:
3621:
3596:
3591:
3581:
3494:
3488:
3478:
3175:
3170:
3165:
1342:
1302:
327:
224:
174:
1775:
1688:
1671:
1238:. The protein becomes activated when binding to receptors capable of protein
6121:
6091:
6086:
6081:
6076:
6071:
6051:
6041:
6031:
6021:
5713:
5673:
5569:
5544:
5303:
5298:
5293:
5283:
5278:
5273:
5263:
5184:
5122:
5056:
5036:
5031:
5026:
5011:
5006:
4996:
4991:
4885:
4860:
4625:
4545:
4464:
4409:
4299:
4238:
4228:
4133:
4020:
3818:
3813:
3803:
3711:
3701:
3686:
3661:
3656:
3646:
3641:
3636:
3276:
1957:
866:
571:
449:
394:
381:
293:
280:
182:
2466:
2449:
2448:
Jakowlew SB, Kondaiah P, Dillard PJ, Sporn MB, Roberts AB (November 1988).
2367:
2350:
2181:
2138:
2077:
2025:
1976:
1917:
1881:
1843:
1794:
2734:
2691:
2656:
2627:
2590:
2547:
2518:
2500:
2475:
2440:
2411:
2376:
2341:
2320:
2291:
2262:
2211:
2109:
2059:
1732:
1697:
1653:
1602:
1594:
1196:
1191:
762:
positive regulation of epidermal growth factor-activated receptor activity
6292:
6011:
5668:
5268:
5258:
5238:
5173:
5142:
5111:
5075:
4981:
4971:
4318:
3798:
3741:
3651:
3611:
3086:
2716:
2244:
2172:
2155:
1421:
1180:
1011:
992:
822:
negative regulation of epidermal growth factor receptor signaling pathway
2432:
149:, TFGA, transforming growth factor alpha, Transforming growth factor - α
6267:
5688:
5153:
4555:
3516:
3261:
3200:
2384:
Harvey TS, Wilkinson AJ, Tappin MJ, Cooke RM, Campbell ID (June 1991).
1445:
1441:
1408:
circadian locomotor behavior along with drinking or eating activities.
1334:
1232:
1216:
978:
933:
2539:
2130:
115:
111:
107:
103:
99:
95:
91:
87:
6180:
5844:
5733:
5658:
5363:
5358:
4782:
4777:
4731:
4727:
4723:
4719:
4715:
4711:
4707:
4359:
3898:
3576:
2581:
2556:
2007:
1310:
1239:
1164:
888:
6212:
6208:
6204:
6200:
6196:
6192:
6188:
6184:
5899:
5798:
5473:
5413:
5227:
4950:
4946:
4942:
4938:
4429:
4293:
4212:
4208:
4107:
4103:
4099:
4095:
4004:
4000:
3851:
3315:
3310:
3305:
3300:
3256:
3251:
3246:
3241:
3105:
3100:
3095:
3071:
3065:
3059:
3053:
3033:
3029:
3020:
3016:
3007:
3003:
2870:: THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA
2855:: THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA
2386:"The solution structure of human transforming growth factor alpha"
1990:
Coffey RJ, Washington MK, Corless CL, Heinrich MC (January 2007).
1352:
1322:
1318:
2895:
851:
847:
5683:
4289:
4285:
4281:
4277:
4273:
4269:
4204:
4200:
4196:
4192:
4188:
4091:
4087:
4079:
4075:
4071:
4067:
4063:
4059:
4055:
3996:
3992:
3988:
3984:
3980:
3976:
3972:
3924:
3920:
3916:
3882:
3847:
3828:
3025:
3012:
2999:
2977:
2973:
2969:
2964:
2956:
1220:
162:
3389:
2899:
2763:
616:
2759:
2042:
Barr FA, Preisinger C, Kopajtich R, Körner R (December 2001).
726:
endoplasmic reticulum-Golgi intermediate compartment membrane
772:
endoplasmic reticulum to Golgi vesicle-mediated transport
418:
2227:
Thomas DM, Nasim MM, Gullick WJ, Alison MR (May 1992).
6283:
Pituitary adenylate cyclase-activating peptide (PACAP)
2664:
Walz TM, Malm C, Nishikawa BK, Wasteson A (May 1995).
1424:
has been suggested. Elevated TGF-α is associated with
1337:
known as the EGF receptor binds to TGF-α allowing the
1713:
European
Journal of Gastroenterology & Hepatology
583:
1559:"Entrez Gene: TGFA transforming growth factor alpha"
807:
positive regulation of cell population proliferation
767:
positive regulation of epithelial cell proliferation
6150:
5937:
5832:
5601:
5341:
5332:
5312:
5226:
5203:
5172:
5141:
5110:
5074:
5065:
4917:
4760:
4693:
4655:
4522:
4513:
4331:
4308:
4248:
4167:
4034:
3951:
3942:
3881:
3827:
3740:
3544:
3535:
3504:
3426:
3362:
3324:
3291:
3228:
3197:
3186:
3151:
3123:
3081:
3042:
2986:
2942:
2933:
1121:
1088:
1062:
1029:
6229:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5087:Glial cell line-derived neurotrophic factor (GDNF)
4740:Cleavage products/derivatives with unknown target:
1498:
1496:
1494:
1477:
1475:
1473:
802:epidermal growth factor receptor signaling pathway
827:positive regulation of protein kinase B signaling
365:
264:
6263:Macrophage-stimulating protein (MSP; HLP, HGFLP)
1394:The EGF/TGF-α family has been shown to regulate
797:regulation of transcription by RNA polymerase II
3904:Heparin-binding EGF-like growth factor (HB-EGF)
3587:Heparin-binding EGF-like growth factor (HB-EGF)
1360:(EGFR) signaling pathway upon binding to TGF-α.
787:positive regulation of mitotic nuclear division
1744:
1742:
1665:
1663:
1503:GRCm38: Ensembl release 89: ENSMUSG00000029999
6315:Additional growth factor receptor modulators:
3401:
2911:
2775:
1626:
1624:
1622:
1620:
8:
4669:Insulin-like growth factor-2 (somatomedin A)
4551:Insulin-like growth factor-2 (somatomedin A)
4541:Insulin-like growth factor-1 (somatomedin C)
2683:10.1182/blood.V85.9.2385.bloodjournal8592385
2555:Lee DC, Rose TM, Webb NR, Todaro GJ (1985).
2037:
2035:
1576:
1574:
1572:
1570:
1568:
1396:luteinizing hormone-releasing hormone (LHRH)
1855:
1853:
1482:GRCh38: Ensembl release 89: ENSG00000163235
1428:, a precancerous condition of the stomach.
6333:United States National Library of Medicine
5338:
5071:
4519:
3948:
3541:
3408:
3394:
3386:
3194:
2939:
2918:
2904:
2896:
2782:
2768:
2760:
862:
632:
522:transitional epithelium of urinary bladder
406:
305:
202:
76:
2752:at the U.S. National Library of Medicine
2724:
2681:
2580:
2508:
2465:
2401:
2366:
2252:
2171:
2067:
2015:
1966:
1956:
1833:
1784:
1774:
1687:
6331:This article incorporates text from the
6273:Migration-stimulating factor (MSF; PRG4)
1553:
1551:
650:epidermal growth factor receptor binding
3602:Transforming growth factor alpha (TGFα)
2797:
1469:
1309:TGF-α has also been shown to stimulate
6176:Connective tissue growth factor (CTGF)
1219:that in humans is encoded by the TGFA
721:ER to Golgi transport vesicle membrane
31:
6239:Hepatoma-derived growth factor (HDGF)
1996:The Journal of Clinical Investigation
696:integral component of plasma membrane
370:
331:
326:
269:
228:
223:
7:
2705:The British Journal of Ophthalmology
1808:Cooper O, Isacson O (October 2004).
792:positive regulation of cell division
538:vestibular membrane of cochlear duct
1676:The Journal of Biological Chemistry
2403:10.1111/j.1432-1033.1991.tb16050.x
2204:10.1111/j.1365-2559.1992.tb00991.x
1118:
1085:
1059:
1026:
1002:
983:
957:
938:
912:
893:
588:
506:
444:
423:
25:
1945:Journal of Translational Medicine
1242:activity for cellular signaling.
837:intracellular signal transduction
6258:Leukemia inhibitory factor (LIF)
2875:
2860:
2845:
2830:
2815:
2800:
2750:Transforming+Growth+Factor+alpha
2390:European Journal of Biochemistry
2160:American Journal of Epidemiology
1910:10.1111/j.1365-2559.2011.04139.x
1725:10.1097/00042737-199510000-00003
1358:Epidermal growth factor receptor
1255:epidermal growth factor receptor
1209:Transforming growth factor alpha
746:clathrin-coated vesicle membrane
606:
599:
592:
534:lumbar subsegment of spinal cord
354:
347:
341:
318:
253:
246:
240:
215:
40:
5426:Negative allosteric modulators:
3232:Relaxin family peptide hormones
716:perinuclear region of cytoplasm
5744:Gossypetin (3,5,7,8,3',4'-HHF)
4935:Platelet-derived growth factor
2528:Cytogenetics and Cell Genetics
2489:Molecular and Cellular Biology
1874:10.1016/j.brainres.2006.02.100
1826:10.1523/JNEUROSCI.2344-04.2004
1350:signal transduction pathways.
681:endoplasmic reticulum membrane
676:integral component of membrane
617:More reference expression data
572:More reference expression data
1:
5950:Placental growth factor (PGF)
782:cell population proliferation
339:
238:
6234:Glia maturation factor (GMF)
4743:Glypromate (GPE, (1-3)IGF-1)
2645:Histology and Histopathology
2620:10.1016/0092-8674(84)90550-6
2284:10.1016/0003-2697(92)90331-Z
1646:10.1016/0301-0082(96)00009-3
1436:TGF alpha has been shown to
18:Transforming growth factor-α
6353:Genes on human chromosome 2
2048:The Journal of Cell Biology
1814:The Journal of Neuroscience
711:basolateral plasma membrane
6369:
6166:Colony-stimulating factors
6158:Additional growth factors:
3205:Insulin-like growth factor
2313:10.1210/endo.131.2.1639032
2098:Seminars in Cancer Biology
1458:Transforming growth factor
1247:transforming growth factor
5514:SNA-120 (pegylated K252a)
4686:(against IGF-1 and IGF-2)
4648:(against IGF-1 and IGF-2)
2795:
1538:"Mouse PubMed Reference:"
1520:"Human PubMed Reference:"
1289:TGF-α can be produced in
1195:
1190:
1186:
1179:
1163:
1144:
1125:
1092:
1081:
1066:
1033:
1022:
1009:
1005:
990:
986:
977:
964:
960:
945:
941:
932:
919:
915:
900:
896:
887:
872:
865:
861:
845:
635:
631:
614:
591:
582:
569:
518:
509:
484:epithelium of nasopharynx
456:
447:
417:
409:
405:
388:
375:
338:
317:
308:
304:
287:
274:
237:
214:
205:
201:
156:
153:
143:
136:
131:
84:
79:
62:
57:
52:
48:
39:
34:
4350:Hepatocyte growth factor
3909:Neuregulins (heregulins)
3840:Neuregulins (heregulins)
3784:Trastuzumab duocarmazine
3497:(against angiopoietin 2)
3491:(against angiopoietin 3)
2754:Medical Subject Headings
1776:10.1073/pnas.97.26.14686
1689:10.1074/jbc.273.42.27357
1634:Progress in Neurobiology
1277:Synthesis in the stomach
3697:Depatuxizumab mafodotin
3045:FGF homologous factors:
2454:Molecular Endocrinology
2355:Molecular Endocrinology
2272:Analytical Biochemistry
1958:10.1186/1479-5876-12-19
1403:Suprachiasmatic nucleus
1333:A 170-kDa glycosylated
1225:epidermal growth factor
1157:Chr 6: 86.17 – 86.25 Mb
1150:Chr 2: 70.45 – 70.55 Mb
558:suprachiasmatic nucleus
6320:(neurotrophin mixture)
6308:Wnt signaling proteins
5989:Allosteric modulators:
5709:Norwogonin (5,7,8-THF)
3929:5 (tomoregulin, TMEFF)
3779:Trastuzumab deruxtecan
3417:Growth factor receptor
2467:10.1210/mend-2-11-1056
2368:10.1210/mend-5-12-1955
2154:Vieira AR (May 2006).
1896:with gastric cancer".
1369:In an animal model of
1361:
660:growth factor activity
468:pancreatic ductal cell
6248:T-cell growth factors
4505:Telisotuzumab vedotin
3789:Trastuzumab emtansine
2501:10.1128/mcb.8.12.5549
2060:10.1083/jcb.200108102
1595:10.1038/sj.mp.4000307
1390:Neuroendocrine system
1377:have been damaged by
1356:
1223:. As a member of the
832:membrane organization
777:COPII vesicle coating
4833:EVT-901 (SAR-127963)
4566:Mecasermin rinfabate
3326:Vascular endothelial
2717:10.1136/bjo.78.9.714
2245:10.1136/gut.33.5.628
1583:Molecular Psychiatry
1375:dopaminergic neurons
701:extracellular region
372:6 D1|6 37.62 cM
333:Chromosome 6 (mouse)
231:Chromosome 2 (human)
80:List of PDB id codes
53:Available structures
2573:1985Natur.313..489L
2433:10.1021/bi00486a005
1767:2000PNAS...9714686F
1761:(26): 14686–14691.
1682:(42): 27357–27363.
1426:Menetrier's disease
1371:Parkinson's disease
817:signal transduction
741:extracellular space
731:cytoplasmic vesicle
472:islet of Langerhans
6335:, which is in the
5999:Kinase inhibitors:
5862:Kinase inhibitors:
5761:Kinase inhibitors:
5436:Kinase inhibitors:
5251:Kinase inhibitors:
5211:Kinase inhibitors:
5192:Kinase inhibitors:
5161:Kinase inhibitors:
5130:Kinase inhibitors:
5099:Kinase inhibitors:
4959:Kinase inhibitors:
4573:Kinase inhibitors:
4367:Kinase inhibitors:
4156:Kinase inhibitors:
4149:Aprutumab ixadotin
3796:Kinase inhibitors:
3609:Kinase inhibitors:
3466:Kinase inhibitors:
2173:10.1093/aje/kwj103
1362:
967:ENSMUSG00000029999
755:Biological process
669:Cellular component
643:Molecular function
526:olfactory tubercle
488:buccal mucosa cell
6327:
6326:
5933:
5932:
5694:N-Acetylserotonin
5593:ReN-1820 (TrkAd5)
5222:
5221:
4756:
4755:
4701:Binding proteins:
4360:Dihexa (PNB-0408)
4327:
4326:
3938:
3937:
3852:6 (neuroglycan C)
3572:EGF (urogastrone)
3550:
3383:
3382:
3287:
3286:
3119:
3118:
2893:
2892:
2567:(6002): 489–491.
2540:10.1159/000132258
2495:(12): 5549–5554.
2460:(11): 1056–1063.
2427:(34): 7805–7813.
2361:(12): 1955–1963.
2336:(11): 2137–2144.
2131:10.1159/000055835
1820:(41): 8924–8931.
1418:gastric carcinoma
1379:6-hydroxydopamine
1301:. TGF-α induces
1206:
1205:
1202:
1201:
1175:
1174:
1140:
1139:
1115:
1114:
1077:
1076:
1056:
1055:
1018:
1017:
999:
998:
973:
972:
954:
953:
928:
927:
909:
908:
857:
856:
627:
626:
623:
622:
578:
577:
565:
564:
546:nucleus accumbens
503:
502:
401:
400:
300:
299:
127:
126:
123:
122:
63:Ortholog search:
16:(Redirected from
6360:
6139:Decoy receptors:
6112:Alacizumab pegol
5590:Decoy receptors:
5339:
5244:Stem cell factor
5185:Persephin (PSPN)
5123:Neurturin (NRTN)
5072:
4909:LEVI-04 (p75-Fc)
4906:Decoy receptors:
4520:
3949:
3548:
3542:
3410:
3403:
3396:
3387:
3293:Platelet-derived
3235:
3208:
3195:
3089:
3047:
2993:
2950:
2940:
2920:
2913:
2906:
2897:
2879:
2864:
2849:
2834:
2819:
2804:
2784:
2777:
2770:
2761:
2738:
2728:
2695:
2685:
2676:(9): 2385–2392.
2660:
2639:
2602:
2584:
2582:10.1038/313489a0
2551:
2522:
2512:
2479:
2469:
2444:
2415:
2405:
2380:
2370:
2345:
2324:
2295:
2266:
2256:
2223:
2185:
2175:
2150:
2113:
2082:
2081:
2071:
2039:
2030:
2029:
2019:
2008:10.1172/JCI30491
1987:
1981:
1980:
1970:
1960:
1936:
1930:
1929:
1892:
1886:
1885:
1857:
1848:
1847:
1837:
1805:
1799:
1798:
1788:
1778:
1746:
1737:
1736:
1708:
1702:
1701:
1691:
1667:
1658:
1657:
1628:
1615:
1614:
1578:
1563:
1562:
1555:
1546:
1545:
1534:
1528:
1527:
1516:
1510:
1500:
1489:
1479:
1259:cleft lip/palate
1188:
1187:
1159:
1152:
1135:
1119:
1110:
1086:
1082:RefSeq (protein)
1072:
1060:
1051:
1027:
1003:
984:
958:
939:
913:
894:
863:
633:
619:
610:
603:
596:
589:
574:
514:
512:Top expressed in
507:
492:nasal epithelium
452:
450:Top expressed in
445:
424:
407:
397:
384:
373:
358:
351:
345:
334:
322:
306:
296:
283:
272:
257:
250:
244:
233:
219:
203:
197:
195:TGFA - orthologs
148:
141:
118:
77:
71:
50:
49:
44:
32:
21:
6368:
6367:
6363:
6362:
6361:
6359:
6358:
6357:
6343:
6342:
6328:
6323:
6268:Midkine (NEGF2)
6146:
5929:
5828:
5597:
5535:ABT-110 (PG110)
5328:
5308:
5218:
5199:
5168:
5137:
5106:
5061:
4913:
4851:ABT-110 (PG110)
4752:
4689:
4651:
4509:
4323:
4304:
4244:
4241:(against FGF23)
4163:
4030:
3934:
3877:
3823:
3736:
3547:
3531:
3500:
3422:
3414:
3384:
3379:
3358:
3320:
3283:
3229:
3224:
3198:
3189:
3182:
3147:
3125:EGF-like domain
3115:
3082:
3077:
3043:
3038:
2987:
2982:
2943:
2929:
2924:
2894:
2889:
2886:
2880:
2871:
2865:
2856:
2850:
2841:
2835:
2826:
2820:
2811:
2805:
2791:
2788:
2746:
2741:
2698:
2663:
2642:
2605:
2554:
2525:
2482:
2447:
2418:
2383:
2348:
2327:
2298:
2269:
2226:
2188:
2153:
2116:
2095:
2091:
2089:Further reading
2086:
2085:
2041:
2040:
2033:
1989:
1988:
1984:
1938:
1937:
1933:
1894:
1893:
1889:
1859:
1858:
1851:
1807:
1806:
1802:
1748:
1747:
1740:
1710:
1709:
1705:
1669:
1668:
1661:
1630:
1629:
1618:
1580:
1579:
1566:
1557:
1556:
1549:
1536:
1535:
1531:
1518:
1517:
1513:
1501:
1492:
1480:
1471:
1466:
1454:
1434:
1414:
1405:
1392:
1387:
1367:
1331:
1287:
1279:
1267:
1197:View/Edit Mouse
1192:View/Edit Human
1155:
1148:
1145:Location (UCSC)
1131:
1127:
1106:
1102:
1098:
1094:
1068:
1047:
1043:
1039:
1035:
948:ENSG00000163235
841:
750:
691:plasma membrane
664:
655:protein binding
615:
605:
604:
598:
597:
570:
561:
556:
554:globus pallidus
552:
548:
544:
540:
536:
532:
528:
524:
510:
499:
496:corpus callosum
494:
490:
486:
482:
478:
474:
470:
466:
462:
448:
392:
379:
371:
361:
360:
359:
352:
332:
309:Gene location (
291:
278:
270:
260:
259:
258:
251:
229:
206:Gene location (
157:
144:
137:
86:
64:
28:
23:
22:
15:
12:
11:
5:
6366:
6364:
6356:
6355:
6345:
6344:
6325:
6324:
6322:
6321:
6311:
6310:
6305:
6298:Thrombopoietin
6295:
6290:
6285:
6280:
6275:
6270:
6265:
6260:
6255:
6241:
6236:
6231:
6226:
6219:Erythropoietin
6216:
6178:
6173:
6163:
6161:Adrenomedullin
6154:
6152:
6148:
6147:
6145:
6144:
6135:
6134:
6129:
6124:
6119:
6114:
6105:
6104:
6099:
6094:
6089:
6084:
6079:
6074:
6069:
6064:
6059:
6054:
6049:
6044:
6039:
6034:
6029:
6024:
6019:
6014:
6009:
6004:
5995:
5994:
5985:
5984:
5962:
5957:
5952:
5943:
5941:
5935:
5934:
5931:
5930:
5928:
5927:
5922:
5917:
5912:
5907:
5902:
5897:
5892:
5887:
5882:
5877:
5872:
5867:
5858:
5857:
5852:
5847:
5838:
5836:
5830:
5829:
5827:
5826:
5821:
5816:
5811:
5806:
5801:
5796:
5791:
5786:
5781:
5776:
5771:
5766:
5757:
5756:
5747:
5746:
5741:
5736:
5727:
5726:
5721:
5716:
5711:
5706:
5701:
5696:
5691:
5686:
5681:
5676:
5671:
5666:
5661:
5656:
5651:
5646:
5641:
5636:
5631:
5626:
5624:4'-DMA-7,8-DHF
5621:
5616:
5607:
5605:
5599:
5598:
5596:
5595:
5586:
5585:
5573:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5518:
5517:
5511:
5506:
5501:
5496:
5491:
5486:
5481:
5476:
5471:
5466:
5461:
5456:
5451:
5446:
5441:
5432:
5431:
5422:
5421:
5416:
5411:
5406:
5397:
5396:
5391:
5386:
5384:Gambogic amide
5381:
5376:
5371:
5366:
5361:
5356:
5347:
5345:
5336:
5330:
5329:
5327:
5326:
5318:
5316:
5310:
5309:
5307:
5306:
5301:
5296:
5291:
5286:
5281:
5276:
5271:
5266:
5261:
5256:
5247:
5246:
5241:
5232:
5230:
5224:
5223:
5220:
5219:
5217:
5216:
5207:
5205:
5201:
5200:
5198:
5197:
5188:
5187:
5178:
5176:
5170:
5169:
5167:
5166:
5157:
5156:
5154:Artemin (ARTN)
5147:
5145:
5139:
5138:
5136:
5135:
5126:
5125:
5116:
5114:
5108:
5107:
5105:
5104:
5095:
5094:
5089:
5080:
5078:
5069:
5063:
5062:
5060:
5059:
5054:
5049:
5040:
5039:
5034:
5029:
5024:
5019:
5014:
5009:
5004:
4999:
4994:
4989:
4984:
4979:
4974:
4969:
4964:
4955:
4954:
4932:
4923:
4921:
4915:
4914:
4912:
4911:
4902:
4901:
4889:
4888:
4883:
4878:
4873:
4868:
4863:
4858:
4853:
4841:
4840:
4835:
4830:
4825:
4816:
4815:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4775:
4766:
4764:
4758:
4757:
4754:
4753:
4751:
4750:
4745:
4736:
4735:
4697:
4695:
4691:
4690:
4688:
4687:
4681:
4672:
4671:
4661:
4659:
4653:
4652:
4650:
4649:
4643:
4638:
4633:
4628:
4623:
4618:
4613:
4608:
4599:
4598:
4593:
4588:
4583:
4578:
4569:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4528:
4526:
4517:
4511:
4510:
4508:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4468:
4467:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4363:
4362:
4353:
4352:
4347:
4337:
4335:
4329:
4328:
4325:
4324:
4322:
4321:
4312:
4310:
4306:
4305:
4303:
4302:
4297:
4263:
4254:
4252:
4246:
4245:
4243:
4242:
4232:
4231:
4226:
4221:
4216:
4182:
4173:
4171:
4165:
4164:
4162:
4161:
4152:
4151:
4146:
4137:
4136:
4131:
4126:
4121:
4116:
4111:
4049:
4040:
4038:
4032:
4031:
4029:
4028:
4023:
4018:
4013:
4008:
3966:
3957:
3955:
3946:
3940:
3939:
3936:
3935:
3933:
3932:
3906:
3901:
3896:
3887:
3885:
3879:
3878:
3876:
3875:
3870:
3865:
3856:
3855:
3833:
3831:
3825:
3824:
3822:
3821:
3816:
3811:
3806:
3801:
3792:
3791:
3786:
3781:
3776:
3771:
3766:
3757:
3756:
3746:
3744:
3738:
3737:
3735:
3734:
3729:
3724:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3680:
3679:
3674:
3669:
3664:
3659:
3654:
3649:
3644:
3639:
3634:
3629:
3624:
3619:
3614:
3605:
3604:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3554:
3552:
3539:
3533:
3532:
3530:
3529:
3524:
3519:
3510:
3508:
3502:
3501:
3499:
3498:
3492:
3482:
3481:
3476:
3471:
3462:
3461:
3459:Angiopoietin 3
3456:
3454:Angiopoietin 2
3447:
3446:
3444:Angiopoietin 4
3441:
3439:Angiopoietin 1
3432:
3430:
3424:
3423:
3415:
3413:
3412:
3405:
3398:
3390:
3381:
3380:
3378:
3377:
3372:
3366:
3364:
3360:
3359:
3357:
3356:
3351:
3346:
3341:
3336:
3330:
3328:
3322:
3321:
3319:
3318:
3313:
3308:
3303:
3297:
3295:
3289:
3288:
3285:
3284:
3282:
3281:
3280:
3279:
3274:
3269:
3259:
3254:
3249:
3244:
3238:
3236:
3226:
3225:
3223:
3222:
3217:
3211:
3209:
3192:
3190:Relaxin family
3184:
3183:
3181:
3180:
3179:
3178:
3173:
3168:
3157:
3155:
3149:
3148:
3146:
3145:
3140:
3135:
3129:
3127:
3121:
3120:
3117:
3116:
3114:
3113:
3108:
3103:
3098:
3092:
3090:
3079:
3078:
3076:
3075:
3069:
3063:
3057:
3050:
3048:
3040:
3039:
3037:
3036:
3023:
3010:
2996:
2994:
2984:
2983:
2981:
2980:
2967:
2953:
2951:
2937:
2931:
2930:
2927:Growth factors
2925:
2923:
2922:
2915:
2908:
2900:
2891:
2890:
2888:
2887:
2881:
2874:
2872:
2866:
2859:
2857:
2851:
2844:
2842:
2836:
2829:
2827:
2821:
2814:
2812:
2806:
2799:
2796:
2793:
2792:
2789:
2787:
2786:
2779:
2772:
2764:
2758:
2757:
2745:
2744:External links
2742:
2740:
2739:
2711:(9): 714–718.
2696:
2661:
2651:(3): 691–696.
2640:
2614:(1): 287–297.
2603:
2552:
2534:(1–2): 94–98.
2523:
2480:
2445:
2416:
2396:(3): 555–562.
2381:
2346:
2325:
2307:(2): 947–957.
2296:
2278:(2): 216–226.
2267:
2239:(5): 628–631.
2224:
2198:(4): 339–343.
2192:Histopathology
2186:
2166:(9): 790–810.
2151:
2125:(4): 363–368.
2114:
2104:(4): 265–275.
2092:
2090:
2087:
2084:
2083:
2054:(6): 885–891.
2031:
1982:
1931:
1904:(2): 153–161.
1898:Histopathology
1887:
1862:Brain Research
1849:
1800:
1738:
1703:
1659:
1616:
1589:(5): 355–358.
1564:
1547:
1529:
1511:
1490:
1468:
1467:
1465:
1462:
1461:
1460:
1453:
1450:
1433:
1430:
1413:
1410:
1404:
1401:
1391:
1388:
1386:
1383:
1366:
1365:Animal studies
1363:
1330:
1327:
1286:
1283:
1278:
1275:
1266:
1263:
1204:
1203:
1200:
1199:
1194:
1184:
1183:
1177:
1176:
1173:
1172:
1170:
1168:
1161:
1160:
1153:
1146:
1142:
1141:
1138:
1137:
1123:
1122:
1116:
1113:
1112:
1090:
1089:
1083:
1079:
1078:
1075:
1074:
1064:
1063:
1057:
1054:
1053:
1031:
1030:
1024:
1020:
1019:
1016:
1015:
1007:
1006:
1000:
997:
996:
988:
987:
981:
975:
974:
971:
970:
962:
961:
955:
952:
951:
943:
942:
936:
930:
929:
926:
925:
917:
916:
910:
907:
906:
898:
897:
891:
885:
884:
879:
874:
870:
869:
859:
858:
855:
854:
843:
842:
840:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
758:
756:
752:
751:
749:
748:
743:
738:
736:Golgi membrane
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
672:
670:
666:
665:
663:
662:
657:
652:
646:
644:
640:
639:
629:
628:
625:
624:
621:
620:
612:
611:
586:
580:
579:
576:
575:
567:
566:
563:
562:
560:
559:
555:
551:
547:
543:
539:
535:
531:
527:
523:
519:
516:
515:
504:
501:
500:
498:
497:
493:
489:
485:
481:
477:
476:amniotic fluid
473:
469:
465:
461:
457:
454:
453:
441:
440:
432:
421:
415:
414:
411:RNA expression
403:
402:
399:
398:
390:
386:
385:
377:
374:
369:
363:
362:
353:
346:
340:
336:
335:
330:
324:
323:
315:
314:
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
227:
221:
220:
212:
211:
199:
198:
155:
151:
150:
142:
134:
133:
129:
128:
125:
124:
121:
120:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6365:
6354:
6351:
6350:
6348:
6341:
6340:
6338:
6337:public domain
6334:
6319:
6316:
6313:
6312:
6309:
6306:
6303:
6299:
6296:
6294:
6291:
6289:
6286:
6284:
6281:
6279:
6276:
6274:
6271:
6269:
6266:
6264:
6261:
6259:
6256:
6253:
6249:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6227:
6224:
6220:
6217:
6214:
6210:
6206:
6202:
6198:
6194:
6190:
6186:
6182:
6179:
6177:
6174:
6171:
6167:
6164:
6162:
6159:
6156:
6155:
6153:
6149:
6143:
6140:
6137:
6136:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6107:
6106:
6103:
6100:
6098:
6095:
6093:
6090:
6088:
6085:
6083:
6080:
6078:
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6058:
6055:
6053:
6050:
6048:
6045:
6043:
6040:
6038:
6035:
6033:
6030:
6028:
6025:
6023:
6020:
6018:
6015:
6013:
6010:
6008:
6005:
6003:
6000:
5997:
5996:
5993:
5992:Cyclotraxin B
5990:
5987:
5986:
5982:
5978:
5974:
5970:
5966:
5963:
5961:
5958:
5956:
5953:
5951:
5948:
5945:
5944:
5942:
5940:
5936:
5926:
5923:
5921:
5918:
5916:
5913:
5911:
5908:
5906:
5905:Larotrectinib
5903:
5901:
5898:
5896:
5893:
5891:
5888:
5886:
5883:
5881:
5878:
5876:
5873:
5871:
5868:
5866:
5863:
5860:
5859:
5856:
5853:
5851:
5848:
5846:
5843:
5840:
5839:
5837:
5835:
5831:
5825:
5822:
5820:
5817:
5815:
5812:
5810:
5807:
5805:
5804:Larotrectinib
5802:
5800:
5797:
5795:
5792:
5790:
5787:
5785:
5782:
5780:
5777:
5775:
5772:
5770:
5767:
5765:
5762:
5759:
5758:
5755:
5752:
5749:
5748:
5745:
5742:
5740:
5739:Cyclotraxin B
5737:
5735:
5732:
5729:
5728:
5725:
5722:
5720:
5717:
5715:
5712:
5710:
5707:
5705:
5702:
5700:
5697:
5695:
5692:
5690:
5687:
5685:
5682:
5680:
5677:
5675:
5672:
5670:
5667:
5665:
5662:
5660:
5657:
5655:
5652:
5650:
5649:Amitriptyline
5647:
5645:
5642:
5640:
5637:
5635:
5632:
5630:
5627:
5625:
5622:
5620:
5617:
5615:
5612:
5609:
5608:
5606:
5604:
5600:
5594:
5591:
5588:
5587:
5584:
5581:
5578:
5575:
5574:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5529:
5526:
5525:Against TrkA:
5523:
5520:
5519:
5515:
5512:
5510:
5507:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5480:
5479:Larotrectinib
5477:
5475:
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5450:
5447:
5445:
5442:
5440:
5437:
5434:
5433:
5430:
5427:
5424:
5423:
5420:
5417:
5415:
5412:
5410:
5409:Dexamethasone
5407:
5405:
5402:
5399:
5398:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5355:
5354:Amitriptyline
5352:
5349:
5348:
5346:
5344:
5340:
5337:
5335:
5331:
5324:
5320:
5319:
5317:
5315:
5311:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5280:
5277:
5275:
5272:
5270:
5267:
5265:
5262:
5260:
5257:
5255:
5252:
5249:
5248:
5245:
5242:
5240:
5237:
5234:
5233:
5231:
5229:
5225:
5215:
5212:
5209:
5208:
5206:
5202:
5196:
5193:
5190:
5189:
5186:
5183:
5180:
5179:
5177:
5175:
5171:
5165:
5162:
5159:
5158:
5155:
5152:
5149:
5148:
5146:
5144:
5140:
5134:
5131:
5128:
5127:
5124:
5121:
5118:
5117:
5115:
5113:
5109:
5103:
5100:
5097:
5096:
5093:
5090:
5088:
5085:
5082:
5081:
5079:
5077:
5073:
5070:
5068:
5064:
5058:
5055:
5053:
5050:
5048:
5045:
5042:
5041:
5038:
5035:
5033:
5030:
5028:
5025:
5023:
5020:
5018:
5015:
5013:
5010:
5008:
5005:
5003:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4957:
4956:
4952:
4948:
4944:
4940:
4936:
4933:
4931:
4928:
4925:
4924:
4922:
4920:
4916:
4910:
4907:
4904:
4903:
4900:
4897:
4894:
4891:
4890:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4846:
4843:
4842:
4839:
4836:
4834:
4831:
4829:
4828:Dexamethasone
4826:
4824:
4821:
4818:
4817:
4814:
4811:
4809:
4806:
4804:
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4774:
4771:
4768:
4767:
4765:
4763:
4759:
4749:
4746:
4744:
4741:
4738:
4737:
4733:
4729:
4725:
4721:
4717:
4713:
4709:
4705:
4702:
4699:
4698:
4696:
4692:
4685:
4682:
4680:
4677:
4674:
4673:
4670:
4666:
4663:
4662:
4660:
4658:
4654:
4647:
4644:
4642:
4639:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4601:
4600:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4571:
4570:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4536:des(1-3)IGF-1
4533:
4530:
4529:
4527:
4525:
4521:
4518:
4516:
4512:
4506:
4503:
4501:
4500:Telisotuzumab
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4470:
4469:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4365:
4364:
4361:
4358:
4357:Potentiators:
4355:
4354:
4351:
4348:
4346:
4342:
4339:
4338:
4336:
4334:
4330:
4320:
4317:
4314:
4313:
4311:
4307:
4301:
4298:
4295:
4291:
4287:
4283:
4279:
4275:
4271:
4267:
4264:
4262:
4259:
4256:
4255:
4253:
4251:
4247:
4240:
4237:
4234:
4233:
4230:
4227:
4225:
4222:
4220:
4219:Selpercatinib
4217:
4214:
4210:
4206:
4202:
4198:
4194:
4190:
4186:
4183:
4181:
4178:
4175:
4174:
4172:
4170:
4166:
4160:
4157:
4154:
4153:
4150:
4147:
4145:
4142:
4139:
4138:
4135:
4132:
4130:
4127:
4125:
4124:Selpercatinib
4122:
4120:
4117:
4115:
4112:
4109:
4105:
4101:
4097:
4093:
4089:
4085:
4081:
4077:
4073:
4069:
4065:
4061:
4057:
4053:
4050:
4048:
4045:
4042:
4041:
4039:
4037:
4033:
4027:
4024:
4022:
4019:
4017:
4016:Selpercatinib
4014:
4012:
4009:
4006:
4002:
3998:
3994:
3990:
3986:
3982:
3978:
3974:
3970:
3967:
3965:
3962:
3959:
3958:
3956:
3954:
3950:
3947:
3945:
3941:
3930:
3926:
3922:
3918:
3914:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3889:
3888:
3886:
3884:
3880:
3874:
3871:
3869:
3866:
3864:
3861:
3858:
3857:
3853:
3849:
3845:
3841:
3838:
3835:
3834:
3832:
3830:
3826:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3794:
3793:
3790:
3787:
3785:
3782:
3780:
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3759:
3758:
3755:
3751:
3748:
3747:
3745:
3743:
3739:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3692:Depatuxizumab
3690:
3688:
3685:
3682:
3681:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3628:
3625:
3623:
3620:
3618:
3615:
3613:
3610:
3607:
3606:
3603:
3600:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3559:
3556:
3555:
3553:
3551:
3543:
3540:
3538:
3534:
3528:
3525:
3523:
3520:
3518:
3515:
3512:
3511:
3509:
3507:
3503:
3496:
3493:
3490:
3487:
3484:
3483:
3480:
3477:
3475:
3472:
3470:
3467:
3464:
3463:
3460:
3457:
3455:
3452:
3449:
3448:
3445:
3442:
3440:
3437:
3434:
3433:
3431:
3429:
3425:
3421:
3418:
3411:
3406:
3404:
3399:
3397:
3392:
3391:
3388:
3376:
3373:
3371:
3368:
3367:
3365:
3361:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3332:
3331:
3329:
3327:
3323:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3298:
3296:
3294:
3290:
3278:
3275:
3273:
3270:
3268:
3265:
3264:
3263:
3260:
3258:
3255:
3253:
3250:
3248:
3245:
3243:
3240:
3239:
3237:
3234:
3233:
3227:
3221:
3218:
3216:
3213:
3212:
3210:
3207:
3206:
3202:
3196:
3193:
3191:
3185:
3177:
3174:
3172:
3169:
3167:
3164:
3163:
3162:
3159:
3158:
3156:
3154:
3150:
3144:
3141:
3139:
3136:
3134:
3131:
3130:
3128:
3126:
3122:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3093:
3091:
3088:
3085:
3084:hormone-like:
3080:
3073:
3070:
3067:
3064:
3061:
3058:
3055:
3052:
3051:
3049:
3046:
3041:
3035:
3031:
3027:
3024:
3022:
3018:
3014:
3011:
3009:
3005:
3001:
2998:
2997:
2995:
2992:
2991:
2985:
2979:
2975:
2971:
2968:
2966:
2962:
2958:
2955:
2954:
2952:
2949:
2947:
2941:
2938:
2936:
2932:
2928:
2921:
2916:
2914:
2909:
2907:
2902:
2901:
2898:
2884:
2878:
2873:
2869:
2863:
2858:
2854:
2848:
2843:
2839:
2833:
2828:
2824:
2818:
2813:
2809:
2803:
2798:
2794:
2785:
2780:
2778:
2773:
2771:
2766:
2765:
2762:
2755:
2751:
2748:
2747:
2743:
2736:
2732:
2727:
2722:
2718:
2714:
2710:
2706:
2702:
2697:
2693:
2689:
2684:
2679:
2675:
2671:
2667:
2662:
2658:
2654:
2650:
2646:
2641:
2637:
2633:
2629:
2625:
2621:
2617:
2613:
2609:
2604:
2600:
2596:
2592:
2588:
2583:
2578:
2574:
2570:
2566:
2562:
2558:
2553:
2549:
2545:
2541:
2537:
2533:
2529:
2524:
2520:
2516:
2511:
2506:
2502:
2498:
2494:
2490:
2486:
2481:
2477:
2473:
2468:
2463:
2459:
2455:
2451:
2446:
2442:
2438:
2434:
2430:
2426:
2422:
2417:
2413:
2409:
2404:
2399:
2395:
2391:
2387:
2382:
2378:
2374:
2369:
2364:
2360:
2356:
2352:
2347:
2343:
2339:
2335:
2331:
2326:
2322:
2318:
2314:
2310:
2306:
2302:
2301:Endocrinology
2297:
2293:
2289:
2285:
2281:
2277:
2273:
2268:
2264:
2260:
2255:
2250:
2246:
2242:
2238:
2234:
2230:
2225:
2221:
2217:
2213:
2209:
2205:
2201:
2197:
2193:
2187:
2183:
2179:
2174:
2169:
2165:
2161:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2128:
2124:
2120:
2119:Pancreatology
2115:
2111:
2107:
2103:
2099:
2094:
2093:
2088:
2079:
2075:
2070:
2065:
2061:
2057:
2053:
2049:
2045:
2038:
2036:
2032:
2027:
2023:
2018:
2013:
2009:
2005:
2001:
1997:
1993:
1986:
1983:
1978:
1974:
1969:
1964:
1959:
1954:
1950:
1946:
1942:
1935:
1932:
1927:
1923:
1919:
1915:
1911:
1907:
1903:
1899:
1891:
1888:
1883:
1879:
1875:
1871:
1867:
1863:
1856:
1854:
1850:
1845:
1841:
1836:
1831:
1827:
1823:
1819:
1815:
1811:
1804:
1801:
1796:
1792:
1787:
1782:
1777:
1772:
1768:
1764:
1760:
1756:
1752:
1745:
1743:
1739:
1734:
1730:
1726:
1722:
1719:(10): 923–7.
1718:
1714:
1707:
1704:
1699:
1695:
1690:
1685:
1681:
1677:
1673:
1666:
1664:
1660:
1655:
1651:
1647:
1643:
1640:(2): 99–123.
1639:
1635:
1627:
1625:
1623:
1621:
1617:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1577:
1575:
1573:
1571:
1569:
1565:
1560:
1554:
1552:
1548:
1543:
1539:
1533:
1530:
1525:
1521:
1515:
1512:
1508:
1504:
1499:
1497:
1495:
1491:
1487:
1483:
1478:
1476:
1474:
1470:
1463:
1459:
1456:
1455:
1451:
1449:
1447:
1443:
1439:
1431:
1429:
1427:
1423:
1419:
1411:
1409:
1402:
1400:
1397:
1389:
1385:Human studies
1384:
1382:
1380:
1376:
1372:
1364:
1359:
1355:
1351:
1347:
1344:
1340:
1336:
1328:
1326:
1324:
1320:
1316:
1315:proliferation
1312:
1307:
1304:
1300:
1299:keratinocytes
1296:
1292:
1284:
1282:
1276:
1274:
1271:
1264:
1262:
1260:
1256:
1252:
1248:
1243:
1241:
1237:
1234:
1231:, TGF-α is a
1230:
1226:
1222:
1218:
1214:
1210:
1198:
1193:
1189:
1185:
1182:
1178:
1171:
1169:
1166:
1162:
1158:
1154:
1151:
1147:
1143:
1136:
1134:
1130:
1124:
1120:
1117:
1111:
1109:
1105:
1101:
1097:
1091:
1087:
1084:
1080:
1073:
1071:
1065:
1061:
1058:
1052:
1050:
1046:
1042:
1038:
1032:
1028:
1025:
1023:RefSeq (mRNA)
1021:
1014:
1013:
1008:
1004:
1001:
995:
994:
989:
985:
982:
980:
976:
969:
968:
963:
959:
956:
950:
949:
944:
940:
937:
935:
931:
924:
923:
918:
914:
911:
905:
904:
899:
895:
892:
890:
886:
883:
880:
878:
875:
871:
868:
864:
860:
853:
849:
844:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
759:
757:
754:
753:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
673:
671:
668:
667:
661:
658:
656:
653:
651:
648:
647:
645:
642:
641:
638:
637:Gene ontology
634:
630:
618:
613:
609:
602:
595:
590:
587:
585:
581:
573:
568:
557:
553:
549:
545:
541:
537:
533:
529:
525:
521:
520:
517:
513:
508:
505:
495:
491:
487:
483:
479:
475:
471:
467:
464:skin of thigh
463:
459:
458:
455:
451:
446:
443:
442:
439:
437:
433:
431:
430:
426:
425:
422:
420:
416:
412:
408:
404:
396:
391:
387:
383:
378:
368:
364:
357:
350:
344:
337:
329:
325:
321:
316:
312:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
232:
226:
222:
218:
213:
209:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
152:
147:
140:
135:
130:
119:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
6330:
6329:
6318:Cerebrolysin
6314:
6288:Pleiotrophin
6244:Interleukins
6157:
6138:
6108:
6027:Fruquintinib
6017:Cabozantinib
5998:
5988:
5946:
5910:Lestaurtinib
5861:
5841:
5809:Lestaurtinib
5760:
5750:
5731:Antagonists:
5730:
5664:Deoxygedunin
5619:3,7,8,2'-THF
5610:
5589:
5580:Against NGF:
5579:
5576:
5532:Against NGF:
5531:
5524:
5521:
5484:Lestaurtinib
5435:
5425:
5419:Testosterone
5401:Antagonists:
5400:
5350:
5250:
5235:
5210:
5191:
5181:
5160:
5150:
5129:
5119:
5098:
5083:
5043:
4958:
4926:
4905:
4896:Against NGF:
4895:
4892:
4848:Against NGF:
4847:
4844:
4838:Testosterone
4820:Antagonists:
4819:
4769:
4739:
4700:
4675:
4664:
4641:Teprotumumab
4602:
4572:
4531:
4480:Ficlatuzumab
4475:Emibetuzumab
4471:
4425:JNJ-38877605
4395:Cabozantinib
4366:
4356:
4345:Fosgonimeton
4340:
4315:
4257:
4235:
4176:
4159:Infigratinib
4155:
4140:
4043:
3960:
3894:Betacellulin
3890:
3873:Seribantumab
3859:
3836:
3795:
3760:
3754:Unknown/none
3753:
3749:
3683:
3608:
3567:Betacellulin
3562:Amphiregulin
3557:
3549:(ErbB1/HER1)
3513:
3485:
3465:
3451:Antagonists:
3450:
3435:
3428:Angiopoietin
3230:
3199:
3188:Insulin/IGF/
3153:TGFβ pathway
3132:
3083:
3044:
2988:
2946:FGF receptor
2944:
2882:
2867:
2852:
2837:
2822:
2807:
2708:
2704:
2673:
2669:
2648:
2644:
2611:
2607:
2564:
2560:
2531:
2527:
2492:
2488:
2457:
2453:
2424:
2421:Biochemistry
2420:
2393:
2389:
2358:
2354:
2333:
2329:
2304:
2300:
2275:
2271:
2236:
2232:
2195:
2191:
2163:
2159:
2122:
2118:
2101:
2097:
2051:
2047:
2002:(1): 70–80.
1999:
1995:
1985:
1948:
1944:
1934:
1901:
1897:
1890:
1865:
1861:
1817:
1813:
1803:
1758:
1754:
1716:
1712:
1706:
1679:
1675:
1637:
1633:
1586:
1582:
1541:
1532:
1523:
1514:
1435:
1432:Interactions
1415:
1406:
1393:
1368:
1348:
1332:
1308:
1288:
1280:
1272:
1268:
1244:
1212:
1208:
1207:
1133:NP_001390047
1126:
1104:NP_001295088
1100:NP_001295087
1096:NP_001093161
1093:
1067:
1045:NM_001308159
1041:NM_001308158
1037:NM_001099691
1034:
1010:
991:
965:
946:
920:
901:
881:
876:
812:MAPK cascade
706:cell surface
434:
427:
154:External IDs
85:
29:
6278:Oncomodulin
6142:Aflibercept
6132:Ranibizumab
6127:Ramucirumab
6117:Bevacizumab
6109:Antibodies:
6067:Regorafenib
6007:Altiratinib
5920:ONO-5390556
5890:Entrectinib
5865:Altiratinib
5819:ONO-5390556
5789:Entrectinib
5764:Altiratinib
5550:Frunevetmab
5522:Antibodies:
5499:ONO-5390556
5464:Entrectinib
5439:Altiratinib
5394:Tavilermide
5289:Quizartinib
5228:SCF (c-Kit)
5052:Ramucirumab
5044:Antibodies:
5017:Quizartinib
4967:Avapritinib
4930:Becaplermin
4866:Frunevetmab
4845:Antibodies:
4748:Trofinetide
4679:Dusigitumab
4676:Antibodies:
4631:Robatumumab
4621:Figitumumab
4616:Dalotuzumab
4611:Cixutumumab
4603:Antibodies:
4495:Rilotumumab
4490:Onartuzumab
4485:Flanvotumab
4472:Antibodies:
4440:PF-04217903
4370:Altiratinib
4333:HGF (c-Met)
4236:Antibodies:
4141:Antibodies:
3863:Duligotumab
3860:Antibodies:
3774:Trastuzumab
3764:Ertumaxomab
3761:Antibodies:
3732:Zalutumumab
3727:Panitumumab
3722:Nimotuzumab
3717:Necitumumab
3707:Imgatuzumab
3684:Antibodies:
3667:Osimertinib
3632:Dacomitinib
3527:Dapiclermin
3486:Antibodies:
3469:Altiratinib
2790:PDB gallery
1868:(1): 45–8.
1339:polypeptide
1295:brain cells
1291:macrophages
1245:TGF-α is a
1236:polypeptide
393:86,252,701
380:86,172,205
292:70,554,193
279:70,447,284
132:Identifiers
6097:Vandetanib
6062:Rebastinib
6057:Pegaptanib
6047:Nintedanib
6037:Lenvatinib
6002:Agerafenib
5955:Ripretinib
5880:CH-7057288
5779:CH-7057288
5644:7,8,3'-THF
5639:7,8,2'-THF
5565:Ranevetmab
5555:Fulranumab
5509:Rebastinib
5454:CH-7057288
5369:Cenegermin
5254:Agerafenib
5214:Agerafenib
5195:Vandetanib
5164:Vandetanib
5133:Vandetanib
5102:Vandetanib
5047:Olaratumab
5022:Ripretinib
5002:Nintedanib
4987:Lenvatinib
4977:Crenolanib
4962:Agerafenib
4881:Ranevetmab
4871:Fulranumab
4788:Cenegermin
4762:LNGF (p75)
4684:Xentuzumab
4646:Xentuzumab
4591:NVP-AEW541
4586:NVP-ADW742
4581:Linsitinib
4576:BMS-754807
4561:Mecasermin
4460:Tivantinib
4450:PHA-665752
4445:PF-2341066
4415:Golvatinib
4405:Crizotinib
4400:Capmatinib
4390:BMS-777607
4385:Amuvatinib
4261:Ersofermin
4224:Sprifermin
4180:Ersofermin
4129:Sprifermin
4119:Repifermin
4114:Palifermin
4047:Ersofermin
4026:Velafermin
4011:Repifermin
3964:Ersofermin
3883:ErbB4/HER4
3868:Patritumab
3829:ErbB3/HER3
3809:Mubritinib
3769:Pertuzumab
3742:ErbB2/HER2
3672:Vandetanib
3627:Canertinib
3622:Brigatinib
3617:Agerafenib
3597:Nepidermin
3592:Murodermin
3582:Epiregulin
3537:EGF (ErbB)
3495:Nesvacumab
3489:Evinacumab
3479:Rebastinib
3420:modulators
3375:Hepatocyte
2935:Fibroblast
1509:, May 2017
1488:, May 2017
1464:References
1343:amino acid
1303:epithelial
1249:that is a
550:belly cord
460:C1 segment
438:(ortholog)
175:HomoloGene
6122:Icrucumab
6102:WHI-P 154
6092:Tivozanib
6087:Toceranib
6082:Sunitinib
6077:Sorafenib
6072:Semaxanib
6052:Pazopanib
6042:Motesanib
6032:Lapatinib
6022:Cediranib
5960:Telbermin
5947:Agonists:
5895:GZ-389988
5875:CE-245677
5842:Agonists:
5794:GZ-389988
5774:CE-245677
5674:Diosmetin
5611:Agonists:
5577:Aptamers:
5570:Tanezumab
5545:Fasinumab
5489:Milciclib
5469:GZ-389988
5449:CE-245677
5351:Agonists:
5304:Toceranib
5299:Sunitinib
5294:Sorafenib
5284:Pazopanib
5279:Nilotinib
5274:Masitinib
5264:Dasatinib
5236:Agonists:
5182:Agonists:
5151:Agonists:
5120:Agonists:
5092:Liatermin
5084:Agonists:
5067:RET (GFL)
5057:Tovetumab
5037:Toceranib
5032:Sorafenib
5027:Sunitinib
5012:Radotinib
5007:Pazopanib
4997:Motesanib
4992:Masitinib
4927:Agonists:
4893:Aptamers:
4886:Tanezumab
4861:Fasinumab
4770:Agonists:
4626:Ganitumab
4546:IGF-1 LR3
4465:Volitinib
4420:INCB28060
4410:Foretinib
4316:Agonists:
4300:Trafermin
4258:Agonists:
4239:Burosumab
4229:Trafermin
4177:Agonists:
4144:Aprutumab
4134:Trafermin
4096:10 (KGF2)
4044:Agonists:
4021:Trafermin
4001:10 (KGF2)
3961:Agonists:
3891:Agonists:
3837:Agonists:
3819:Tucatinib
3814:Neratinib
3804:Lapatinib
3712:Matuzumab
3702:Futuximab
3687:Cetuximab
3677:WHI-P 154
3662:Neratinib
3657:Lapatinib
3647:Grandinin
3642:Gefitinib
3637:Erlotinib
3514:Agonists:
3474:CE-245677
3436:Agonists:
1265:Synthesis
1233:mitogenic
1129:NP_112476
1108:NP_003227
1070:NM_031199
1049:NM_003236
867:Orthologs
183:GeneCards
6347:Category
6304:instead)
6293:Renalase
6254:instead)
6225:instead)
6172:instead)
6012:Axitinib
5981:D (FIGF)
5925:PLX-7486
5915:ONO-4474
5870:AZD-6918
5824:PLX-7486
5814:ONO-4474
5769:AZD-6918
5751:Ligands:
5669:Deprenyl
5629:7,3'-DHF
5560:MEDI-578
5540:ASP-6294
5504:PLX-7486
5494:ONO-4474
5444:AZD-6918
5404:ALE-0540
5325:instead.
5269:Imatinib
5259:Axitinib
5239:Ancestim
5204:Unsorted
4982:Imatinib
4972:Axitinib
4876:MEDI-578
4856:ASP-6294
4823:ALE-0540
4665:Agonists
4606:AVE-1642
4532:Agonists
4455:SU-11274
4341:Agonists
4319:FGF15/19
4309:Unsorted
4274:2 (bFGF)
4193:2 (bFGF)
4060:2 (bFGF)
3977:2 (bFGF)
3799:Afatinib
3750:Agonists
3652:Icotinib
3612:Afatinib
3558:Agonists
3087:FGF15/19
2948:ligands:
2636:53275849
2330:Oncogene
2220:73067240
2182:16495466
2147:84256727
2139:12120215
2078:11739402
2026:17200708
1977:24457057
1918:22582975
1882:16630586
1844:15483111
1795:11121069
1611:20268790
1505:–
1484:–
1452:See also
1438:interact
1422:melanoma
1329:Receptor
1321:injured
1285:Function
1253:for the
1181:Wikidata
846:Sources:
686:membrane
480:testicle
6181:Ephrins
5885:DS-6051
5784:DS-6051
5689:LM22A-4
5679:DMAQ-B1
5634:7,8-DHF
5614:3,7-DHF
5583:RBM-004
5528:GBR-900
5459:DS-6051
5429:VM-902A
4899:RBM-004
4596:OSl-906
4556:Insulin
4435:MK-2461
4380:AMG-458
3517:Axokine
3262:Relaxin
3201:Insulin
2735:7947554
2692:7727772
2657:7579819
2628:6088071
2599:4358296
2591:3855503
2569:Bibcode
2548:3459638
2519:2907605
2476:2464748
2441:2261437
2412:2050136
2377:1791840
2342:1658709
2321:1639032
2292:1632509
2263:1612477
2254:1379291
2212:1577411
2110:2103501
2069:2150891
2017:1716220
1968:3909384
1926:6566296
1835:2613225
1763:Bibcode
1733:8590135
1698:9765263
1654:8844822
1603:9322223
1507:Ensembl
1486:Ensembl
1446:GORASP2
1442:GORASP1
1335:protein
1317:in the
1217:protein
1215:) is a
979:UniProt
934:Ensembl
873:Species
852:QuickGO
530:decidua
413:pattern
139:Aliases
27:Protein
6151:Others
5845:BNN-20
5734:ANA-12
5659:BNN-20
5379:DHEA-S
5364:BNN-27
5359:BNN-20
4798:DHEA-S
4783:BNN-27
4778:BNN-20
4694:Others
3899:Epigen
3577:Epigen
3349:VEGF-D
3344:VEGF-C
3339:VEGF-B
3334:VEGF-A
3143:HB-EGF
3074:(FHF4)
3068:(FHF2)
3062:(FHF1)
3056:(FHF3)
2756:(MeSH)
2733:
2726:504912
2723:
2690:
2655:
2634:
2626:
2597:
2589:
2561:Nature
2546:
2517:
2510:365660
2507:
2474:
2439:
2410:
2375:
2340:
2319:
2290:
2261:
2251:
2218:
2210:
2180:
2145:
2137:
2108:
2076:
2066:
2024:
2014:
1975:
1965:
1951:: 19.
1924:
1916:
1880:
1842:
1832:
1793:
1783:
1731:
1696:
1652:
1609:
1601:
1412:Tumors
1373:where
1311:neural
1297:, and
1251:ligand
1240:kinase
1229:family
1227:(EGF)
1167:search
1165:PubMed
1012:P48030
993:P01135
889:Entrez
584:BioGPS
271:2p13.3
163:190170
6300:(see
6250:(see
6221:(see
6168:(see
5900:K252a
5799:K252a
5474:K252a
5414:FX007
5174:GFRα4
5143:GFRα3
5112:GFRα2
5076:GFRα1
4704:IGFBP
4657:IGF-2
4636:R1507
4524:IGF-1
4430:K252a
4250:FGFR4
4169:FGFR3
4036:FGFR2
3953:FGFR1
3370:Nerve
3363:Other
3316:PDGFD
3311:PDGFC
3306:PDGFB
3301:PDGFA
3257:INSL6
3252:INSL5
3247:INSL4
3242:INSL3
3176:TGFβ3
3171:TGFβ2
3166:TGFβ1
3111:FGF23
3106:FGF21
3101:FGF19
3096:FGF15
3072:FGF14
3066:FGF13
3060:FGF12
3054:FGF11
3034:FGF20
3030:FGF16
3021:FGF18
3017:FGF17
3008:FGF22
3004:FGF10
2670:Blood
2632:S2CID
2595:S2CID
2216:S2CID
2143:S2CID
1922:S2CID
1786:18979
1607:S2CID
1440:with
1420:. or
1323:brain
1319:adult
1313:cell
1213:TGF-α
922:21802
882:Mouse
877:Human
848:Amigo
436:Mouse
429:Human
376:Start
311:Mouse
275:Start
208:Human
171:98724
6302:here
6252:here
6223:here
6170:here
5965:VEGF
5939:VEGF
5855:NT-3
5850:DHEA
5834:TrkC
5754:DHEA
5724:TDP6
5704:NT-4
5699:NT-3
5684:HIOC
5654:BDNF
5603:TrkB
5374:DHEA
5343:TrkA
5323:here
5321:See
5314:TGFβ
4919:PDGF
4813:NT-4
4808:NT-3
4793:DHEA
4773:BDNF
3522:CNTF
3506:CNTF
3220:IGF2
3215:IGF1
3203:and
3161:TGFβ
3133:TGFα
3026:FGF9
3013:FGF8
3000:FGF7
2978:FGF6
2974:FGF4
2970:FGF3
2965:FGF5
2961:FGF2
2957:FGF1
2883:4tgf
2868:3tgf
2853:2tgf
2838:1yug
2823:1yuf
2808:1mox
2731:PMID
2688:PMID
2653:PMID
2624:PMID
2608:Cell
2587:PMID
2544:PMID
2515:PMID
2472:PMID
2437:PMID
2408:PMID
2373:PMID
2338:PMID
2317:PMID
2288:PMID
2259:PMID
2208:PMID
2178:PMID
2135:PMID
2106:PMID
2074:PMID
2022:PMID
1973:PMID
1914:PMID
1878:PMID
1866:1088
1840:PMID
1791:PMID
1729:PMID
1694:PMID
1650:PMID
1599:PMID
1444:and
1221:gene
903:7039
419:Bgee
367:Band
328:Chr.
266:Band
225:Chr.
187:TGFA
179:2431
159:OMIM
146:TGFA
116:4TGF
112:3TGF
108:3E50
104:2TGF
100:1YUG
96:1YUF
92:1MOX
88:1GK5
69:RCSB
66:PDBe
35:TGFA
5719:R13
5389:NGF
5334:Trk
4803:NGF
4515:IGF
4375:AM7
4266:FGF
4185:FGF
4086:),
4084:KGF
4052:FGF
3969:FGF
3944:FGF
3546:EGF
3354:PGF
3138:EGF
2990:KGF
2721:PMC
2713:doi
2678:doi
2616:doi
2577:doi
2565:313
2536:doi
2505:PMC
2497:doi
2462:doi
2429:doi
2398:doi
2394:198
2363:doi
2309:doi
2305:131
2280:doi
2276:201
2249:PMC
2241:doi
2233:Gut
2200:doi
2168:doi
2164:163
2127:doi
2064:PMC
2056:doi
2052:155
2012:PMC
2004:doi
2000:117
1963:PMC
1953:doi
1906:doi
1870:doi
1830:PMC
1822:doi
1781:PMC
1771:doi
1721:doi
1684:doi
1680:273
1642:doi
1591:doi
542:lip
389:End
288:End
191:OMA
167:MGI
59:PDB
6349::
6213:B3
6211:,
6209:B2
6207:,
6205:B1
6203:,
6201:A5
6199:,
6197:A4
6195:,
6193:A3
6191:,
6189:A2
6187:,
6185:A1
5979:,
5975:,
5971:,
5714:R7
5530:;
4949:,
4945:,
4941:,
4730:,
4726:,
4722:,
4718:,
4714:,
4710:,
4667::
4534::
4343::
4294:19
4292:,
4288:,
4284:,
4280:,
4276:,
4272:,
4213:23
4211:,
4209:18
4207:,
4203:,
4199:,
4195:,
4191:,
4108:22
4106:,
4104:18
4102:,
4100:17
4098:,
4094:,
4090:,
4078:,
4074:,
4070:,
4066:,
4062:,
4058:,
4005:20
4003:,
3999:,
3995:,
3991:,
3987:,
3983:,
3979:,
3975:,
3927:,
3923:,
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3850:,
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2729:.
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5977:C
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5969:A
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