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Transferrin receptor 1

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TfR1 as a potential new target in cases of human leukemia & lymphoma. InatherYs, in Évry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed efficacy in pre-clinical studies in the therapy of two incurable orphan oncohematological diseases: the adult T cell leukemia (ATLL)
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marker for chorionic villi, especially in necrotic specimens. Among white blood cells and precursors, CD71 is expressed only by erythroid precursors within the normal hematopoietic marrow and spleen, in contrast to glycophorin that marks all types of red blood cells.
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of the antibody-TfR interaction seems to be important determining the success of transcytotic transport over endothelial cells of the BBB. Monovalent TfR interaction favors BBB transport due to altered intracellular sorting pathways.
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Lee HJ, Engelhardt B, Lesley J, Bickel U, Pardridge WM (March 2000). "Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse".
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Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, et al. (May 2011). "Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target".
343: 242: 2200:: Crystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM reconstruction of canine parvovirus and feline transferrin receptor complex 4713: 3083: 1771:
Pardridge WM, Buciak JL, Friden PM (October 1991). "Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo".
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TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. Each monomer binds one holo-
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Speeckaert MM, Speeckaert R, Delanghe JR (December 2010). "Biological and clinical aspects of soluble transferrin receptor".
1463: 228: 203: 52: 4096: 3568: 3563: 3508: 3242: 2691: 1442: 3790: 3513: 145: 3108: 1380: 1963:"The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding" 342: 241: 3820: 2245: 1418: 4255: 2686: 2119: 335: 234: 4737: 4645: 3870: 2765: 1339: 1006: 153: 1355: 1335: 4650: 3834: 987: 4512: 4282: 3177: 3172: 3167: 3157: 2464: 2392: 1722: 1518:"Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin" 1413: 4747: 4627: 4418: 4382: 4299: 2521: 2439: 1827:"Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle" 1359: 1307: 1910: 4619: 4601: 4361: 4356: 4351: 3758: 3471: 2112: 1974: 1529: 1400: 217: 132: 3785: 3604: 1176: 1147: 1143: 1139: 1113: 1084: 1080: 1076: 4637: 3192: 2926: 1943: 1891: 1753: 1703: 177: 1172: 1151: 1109: 1088: 4583: 2084: 2043: 2002: 1935: 1883: 1848: 1807: 1780: 1745: 1695: 1660: 1633: 1598: 1557: 125: 45: 2062: 4679: 4671: 4499: 4290: 3965: 3698: 3619: 3182: 2375: 2301: 2033: 1992: 1982: 1925: 1875: 1838: 1737: 1687: 1625: 1588: 1547: 1537: 587: 422: 353: 297: 252: 1302: 4591: 4537: 4373: 4025: 2561: 2556: 2479: 1825:
Niewoehner J, Bohrmann B, Collin L, Urich E, Sade H, Maier P, et al. (January 2014).
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Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, et al. (February 1998).
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West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000).
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Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981).
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis.
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Johnsen KB, Burkhart A, Thomsen LB, Andresen TL, Moos T (October 2019).
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effects of bivalent interactions redirecting transport to the
2185:: Structure of Human Transferrin Receptor-Transferrin Complex 2083:
Overview of all the structural information available in the
1723:"Targeting the transferrin receptor for brain drug delivery" 1618:
The International Journal of Biochemistry & Cell Biology
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Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985).
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The Journal of Pharmacology and Experimental Therapeutics
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The Journal of Pharmacology and Experimental Therapeutics
1911:"Association of human transferrin receptor with GABARAP" 405: 4687: 1327:
caused by HTLV-1 and the Mantle cell lymphoma (MCL).
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Green F, O'Hare T, Blackwell A, Enns CA (May 2002).
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"Brain iron homeostasis". 1459: 1457: 1455: 1438: 1436: 1434: 352: 251: 1680:Critical Reviews in Clinical Laboratory Sciences 872:cellular response to leukemia inhibitory factor 16:Protein-coding gene in the species Homo sapiens 2097:(Human Transferrin receptor protein 1) at the 1464:GRCm38: Ensembl release 89: ENSMUSG00000022797 4707: 4263: 2226: 2120: 8: 1443:GRCh38: Ensembl release 89: ENSG00000072274 862:positive regulation of T cell proliferation 857:positive regulation of B cell proliferation 817:regulation of cell population proliferation 4714: 4700: 4579: 4414: 4315: 4304: 4295: 4270: 4256: 4248: 2233: 2219: 2211: 2127: 2113: 2105: 902: 612: 393: 292: 189: 63: 2250:list of human clusters of differentiation 2037: 1996: 1986: 1929: 1842: 1592: 1551: 1541: 509:fetal liver hematopoietic progenitor cell 1286:. TfR1 is required for iron import from 842:positive regulation of isotype switching 4455:Iron-responsive element-binding protein 2142: 1430: 807:positive regulation of bone resorption 18: 2061:Morelli L, Luchini C (14 May 2021) . 721:integral component of plasma membrane 357: 318: 313: 256: 215: 210: 7: 4668: 4666: 2026:The Journal of Biological Chemistry 1581:American Journal of Human Genetics 1162: 1129: 1099: 1066: 1042: 1023: 997: 978: 952: 933: 575: 493: 431: 410: 14: 1306:TfR1 = transferrin receptor 1 in 1279:that in humans is encoded by the 630:protein homodimerization activity 4670: 2190: 2175: 2160: 2145: 766:clathrin-coated vesicle membrane 756:external side of plasma membrane 691:HFE-transferrin receptor complex 586: 579: 341: 334: 328: 305: 240: 233: 227: 202: 27: 4610:Phosphoric acids and phosphates 1742:10.1016/j.pneurobio.2019.101665 741:perinuclear region of cytoplasm 1868:Science Translational Medicine 1253:Transferrin receptor protein 1 681:integral component of membrane 597:More reference expression data 559:More reference expression data 1: 4343:Ferroportin (SLC11A3/SLC40A1) 1931:10.1016/S0014-5793(02)02655-8 1354:have been shown to cross the 1350:. Some of the TfR1 targeting 837:cellular iron ion homeostasis 812:receptor-mediated endocytosis 640:transferrin receptor activity 326: 225: 4686:. You can help Knowledge by 1880:10.1126/scitranslmed.3002230 1844:10.1016/j.neuron.2013.10.061 1692:10.3109/10408363.2010.550461 1630:10.1016/j.biocel.2004.02.007 4743:Clusters of differentiation 4733:Genes on human chromosome 3 2246:clusters of differentiation 736:basolateral plasma membrane 650:double-stranded RNA binding 4769: 4665: 1419:Cluster of differentiation 827:viral entry into host cell 802:osteoclast differentiation 4436: 2140: 1499:"Mouse PubMed Reference:" 1481:"Human PubMed Reference:" 1239: 1234: 1230: 1223: 1207: 1194:Chr 3: 196.03 – 196.08 Mb 1188: 1169: 1136: 1125: 1106: 1073: 1062: 1049: 1045: 1030: 1026: 1017: 1004: 1000: 985: 981: 972: 959: 955: 940: 936: 927: 912: 905: 901: 885: 822:regulation of cell growth 645:identical protein binding 615: 611: 594: 578: 569: 556: 505: 496: 443: 434: 404: 396: 392: 375: 362: 325: 304: 295: 291: 274: 261: 224: 201: 192: 188: 143: 140: 130: 123: 118: 71: 66: 49: 44: 39: 35: 26: 21: 4646:Calcium-sensing receptor 4393:Calreticulin/mobilferrin 1730:Progress in Neurobiology 1201:Chr 16: 32.43 – 32.45 Mb 847:receptor internalization 4651:Calcium-binding protein 1653:Danish Medical Bulletin 1379:TfR1 has been shown to 635:virus receptor activity 537:vastus lateralis muscle 479:mucosa of sigmoid colon 4753:Membrane protein stubs 4682:–related article is a 2039:10.1074/jbc.C000664200 1988:10.1073/pnas.95.4.1472 1543:10.1073/pnas.78.7.4515 1414:Transferrin receptor 2 1338:(BBB) is used also in 1330:TfR1 expressed on the 1311: 1298:Structure and function 359:16 B3|16 23.06 cM 4628:Magnesium transporter 4419:Iron-binding proteins 4383:Duodenal cytochrome B 1322:Clinical significance 1308:Human iron metabolism 1305: 867:membrane organization 852:transferrin transport 751:extracellular exosome 676:extracellular vesicle 521:stroma of bone marrow 320:Chromosome 16 (mouse) 4620:Magnesium metabolism 4602:Phosphate metabolism 4352:Transferrin receptor 1401:immunohistochemistry 1340:preclinical research 726:extracellular region 218:Chromosome 3 (human) 67:List of PDB id codes 40:Available structures 1979:1998PNAS...95.1472F 1534:1981PNAS...78.4515S 1356:blood-brain barrier 1336:blood-brain barrier 771:cytoplasmic vesicle 761:extracellular space 746:clathrin-coated pit 701:blood microparticle 459:germinal epithelium 4638:Calcium metabolism 2067:Pathology Outlines 1395:Immunostain marker 1312: 1007:ENSMUSG00000022797 877:iron ion transport 790:Biological process 686:recycling endosome 669:Cellular component 623:Molecular function 525:tibiofemoral joint 4695: 4694: 4663: 4662: 4659: 4658: 4584:Sodium metabolism 4569: 4568: 4500:Copper metabolism 4494: 4493: 4490: 4489: 4406: 4405: 4245: 4244: 2208: 2207: 1399:CD71 is a robust 1332:endothelial cells 1259:), also known as 1250: 1249: 1246: 1245: 1219: 1218: 1184: 1183: 1159: 1158: 1121: 1120: 1096: 1095: 1058: 1057: 1039: 1038: 1013: 1012: 994: 993: 968: 967: 949: 948: 897: 896: 776:endosome membrane 607: 606: 603: 602: 565: 564: 552: 551: 490: 489: 475:periodontal fiber 388: 387: 287: 286: 114: 113: 110: 109: 50:Ortholog search: 4760: 4716: 4709: 4702: 4680:membrane protein 4674: 4667: 4580: 4415: 4316: 4305: 4296: 4291:Transition metal 4283:Metal metabolism 4272: 4265: 4258: 4249: 2235: 2228: 2221: 2212: 2194: 2179: 2164: 2149: 2129: 2122: 2115: 2106: 2071: 2070: 2058: 2052: 2051: 2041: 2017: 2011: 2010: 2000: 1990: 1958: 1952: 1951: 1933: 1915: 1906: 1900: 1899: 1863: 1857: 1856: 1846: 1822: 1816: 1815: 1795: 1789: 1788: 1768: 1762: 1761: 1727: 1718: 1712: 1711: 1675: 1669: 1668: 1648: 1642: 1641: 1613: 1607: 1606: 1596: 1572: 1566: 1565: 1555: 1545: 1513: 1507: 1506: 1495: 1489: 1488: 1477: 1471: 1461: 1450: 1440: 1232: 1231: 1203: 1196: 1179: 1163: 1154: 1130: 1126:RefSeq (protein) 1116: 1100: 1091: 1067: 1043: 1024: 998: 979: 953: 934: 903: 613: 599: 590: 583: 576: 561: 541:digastric muscle 501: 499:Top expressed in 494: 447:endothelial cell 439: 437:Top expressed in 432: 411: 394: 384: 371: 360: 345: 338: 332: 321: 309: 293: 283: 270: 259: 244: 237: 231: 220: 206: 190: 184: 182:TFRC - orthologs 135: 128: 105: 64: 58: 37: 36: 31: 19: 4768: 4767: 4763: 4762: 4761: 4759: 4758: 4757: 4738:Iron metabolism 4723: 4722: 4721: 4720: 4664: 4655: 4632: 4614: 4596: 4565: 4538:Zinc metabolism 4532: 4486: 4432: 4402: 4374:Iron(III) oxide 4368: 4310: 4300:Iron metabolism 4285: 4276: 4246: 4241: 4045: 3839: 3588: 3272: 2995: 2655: 2253: 2239: 2209: 2204: 2201: 2195: 2186: 2180: 2171: 2165: 2156: 2150: 2136: 2133: 2080: 2075: 2074: 2060: 2059: 2055: 2032:(49): 38135–8. 2019: 2018: 2014: 1960: 1959: 1955: 1913: 1908: 1907: 1903: 1865: 1864: 1860: 1824: 1823: 1819: 1797: 1796: 1792: 1770: 1769: 1765: 1725: 1720: 1719: 1715: 1686:(5–6): 213–28. 1677: 1676: 1672: 1650: 1649: 1645: 1624:(11): 2137–43. 1615: 1614: 1610: 1574: 1573: 1569: 1515: 1514: 1510: 1497: 1496: 1492: 1479: 1478: 1474: 1462: 1453: 1441: 1432: 1427: 1410: 1397: 1377: 1324: 1300: 1267:ifferentiation 1241:View/Edit Mouse 1236:View/Edit Human 1199: 1192: 1189:Location (UCSC) 1175: 1171: 1150: 1146: 1142: 1138: 1112: 1108: 1087: 1083: 1079: 1075: 988:ENSG00000072274 881: 785: 716:plasma membrane 664: 660:protein binding 595: 585: 584: 557: 548: 543: 539: 535: 531: 529:temporal muscle 527: 523: 519: 515: 511: 497: 486: 481: 477: 473: 471:parietal pleura 469: 465: 463:visceral pleura 461: 457: 453: 451:trabecular bone 449: 435: 379: 366: 358: 348: 347: 346: 339: 319: 296:Gene location ( 278: 265: 257: 247: 246: 245: 238: 216: 193:Gene location ( 144: 131: 124: 73: 51: 17: 12: 11: 5: 4766: 4764: 4756: 4755: 4750: 4745: 4740: 4735: 4725: 4724: 4719: 4718: 4711: 4704: 4696: 4693: 4692: 4675: 4661: 4660: 4657: 4656: 4654: 4653: 4648: 4642: 4640: 4634: 4633: 4631: 4630: 4624: 4622: 4616: 4615: 4613: 4612: 4606: 4604: 4598: 4597: 4595: 4594: 4588: 4586: 4577: 4571: 4570: 4567: 4566: 4564: 4563: 4558: 4553: 4548: 4542: 4540: 4534: 4533: 4531: 4530: 4525: 4520: 4515: 4510: 4504: 4502: 4496: 4495: 4492: 4491: 4488: 4487: 4485: 4484: 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3731: 3726: 3721: 3716: 3711: 3706: 3701: 3696: 3690: 3681: 3676: 3675: 3674: 3669: 3659: 3654: 3653: 3652: 3647: 3637: 3632: 3627: 3622: 3617: 3612: 3607: 3602: 3596: 3594: 3590: 3589: 3587: 3586: 3581: 3576: 3571: 3566: 3561: 3556: 3551: 3546: 3541: 3536: 3531: 3526: 3521: 3516: 3511: 3506: 3501: 3500: 3499: 3494: 3484: 3479: 3474: 3469: 3468: 3467: 3462: 3457: 3447: 3442: 3437: 3432: 3427: 3426: 3425: 3420: 3410: 3405: 3400: 3395: 3390: 3385: 3380: 3379: 3378: 3373: 3363: 3357: 3352: 3347: 3342: 3333: 3328: 3327: 3326: 3321: 3316: 3306: 3301: 3296: 3291: 3286: 3280: 3278: 3274: 3273: 3271: 3270: 3265: 3260: 3255: 3250: 3245: 3240: 3235: 3230: 3225: 3220: 3215: 3210: 3205: 3200: 3195: 3190: 3185: 3180: 3175: 3170: 3165: 3160: 3155: 3150: 3145: 3144: 3143: 3138: 3128: 3127: 3126: 3121: 3111: 3106: 3101: 3096: 3091: 3086: 3081: 3076: 3071: 3066: 3061: 3056: 3051: 3050: 3049: 3044: 3034: 3029: 3024: 3019: 3014: 3009: 3003: 3001: 2997: 2996: 2994: 2993: 2988: 2983: 2978: 2973: 2968: 2963: 2958: 2953: 2944: 2939: 2934: 2929: 2924: 2919: 2918: 2917: 2912: 2907: 2902: 2897: 2892: 2882: 2877: 2872: 2867: 2862: 2857: 2856: 2855: 2850: 2840: 2835: 2830: 2825: 2820: 2815: 2810: 2805: 2800: 2799: 2798: 2793: 2788: 2783: 2778: 2773: 2763: 2762: 2761: 2756: 2751: 2741: 2736: 2735: 2734: 2729: 2724: 2714: 2709: 2704: 2699: 2694: 2689: 2684: 2679: 2674: 2669: 2663: 2661: 2657: 2656: 2654: 2653: 2648: 2647: 2646: 2641: 2636: 2631: 2626: 2621: 2611: 2606: 2601: 2596: 2591: 2586: 2581: 2580: 2579: 2574: 2569: 2564: 2554: 2549: 2544: 2539: 2534: 2529: 2524: 2519: 2514: 2509: 2508: 2507: 2502: 2492: 2487: 2482: 2477: 2472: 2467: 2462: 2457: 2452: 2447: 2442: 2437: 2432: 2427: 2422: 2421: 2420: 2415: 2405: 2400: 2395: 2390: 2389: 2388: 2383: 2378: 2373: 2363: 2358: 2353: 2352: 2351: 2341: 2336: 2331: 2326: 2321: 2320: 2319: 2314: 2309: 2299: 2294: 2293: 2292: 2287: 2282: 2277: 2272: 2261: 2259: 2255: 2254: 2240: 2238: 2237: 2230: 2223: 2215: 2206: 2205: 2203: 2202: 2196: 2189: 2187: 2181: 2174: 2172: 2166: 2159: 2157: 2151: 2144: 2141: 2138: 2137: 2134: 2132: 2131: 2124: 2117: 2109: 2103: 2102: 2079: 2078:External links 2076: 2073: 2072: 2053: 2012: 1953: 1924:(1–3): 101–6. 1901: 1874:(84): 84ra44. 1858: 1817: 1806:(3): 1048–52. 1790: 1763: 1713: 1670: 1659:(4): 279–301. 1643: 1608: 1567: 1508: 1490: 1472: 1451: 1429: 1428: 1426: 1423: 1422: 1421: 1416: 1409: 1406: 1396: 1393: 1376: 1373: 1323: 1320: 1299: 1296: 1290:into cells by 1248: 1247: 1244: 1243: 1238: 1228: 1227: 1221: 1220: 1217: 1216: 1214: 1212: 1205: 1204: 1197: 1190: 1186: 1185: 1182: 1181: 1167: 1166: 1160: 1157: 1156: 1134: 1133: 1127: 1123: 1122: 1119: 1118: 1104: 1103: 1097: 1094: 1093: 1071: 1070: 1064: 1060: 1059: 1056: 1055: 1047: 1046: 1040: 1037: 1036: 1028: 1027: 1021: 1015: 1014: 1011: 1010: 1002: 1001: 995: 992: 991: 983: 982: 976: 970: 969: 966: 965: 957: 956: 950: 947: 946: 938: 937: 931: 925: 924: 919: 914: 910: 909: 899: 898: 895: 894: 883: 882: 880: 879: 874: 869: 864: 859: 854: 849: 844: 839: 834: 829: 824: 819: 814: 809: 804: 799: 793: 791: 787: 786: 784: 783: 781:early endosome 778: 773: 768: 763: 758: 753: 748: 743: 738: 733: 728: 723: 718: 713: 708: 703: 698: 693: 688: 683: 678: 672: 670: 666: 665: 663: 662: 657: 652: 647: 642: 637: 632: 626: 624: 620: 619: 609: 608: 605: 604: 601: 600: 592: 591: 573: 567: 566: 563: 562: 554: 553: 550: 549: 547: 546: 542: 538: 534: 530: 526: 522: 518: 514: 510: 506: 503: 502: 491: 488: 487: 485: 484: 480: 476: 472: 468: 464: 460: 456: 452: 448: 444: 441: 440: 428: 427: 419: 408: 402: 401: 398:RNA expression 390: 389: 386: 385: 377: 373: 372: 364: 361: 356: 350: 349: 340: 333: 327: 323: 322: 317: 311: 310: 302: 301: 289: 288: 285: 284: 276: 272: 271: 263: 260: 255: 249: 248: 239: 232: 226: 222: 221: 214: 208: 207: 199: 198: 186: 185: 142: 138: 137: 129: 121: 120: 116: 115: 112: 111: 108: 107: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 4765: 4754: 4751: 4749: 4746: 4744: 4741: 4739: 4736: 4734: 4731: 4730: 4728: 4717: 4712: 4710: 4705: 4703: 4698: 4697: 4691: 4689: 4685: 4681: 4676: 4673: 4669: 4652: 4649: 4647: 4644: 4643: 4641: 4639: 4635: 4629: 4626: 4625: 4623: 4621: 4617: 4611: 4608: 4607: 4605: 4603: 4599: 4593: 4590: 4589: 4587: 4585: 4581: 4578: 4576: 4572: 4562: 4559: 4557: 4554: 4552: 4549: 4547: 4544: 4543: 4541: 4539: 4535: 4529: 4526: 4524: 4521: 4519: 4518:Ceruloplasmin 4516: 4514: 4511: 4509: 4506: 4505: 4503: 4501: 4497: 4483: 4480: 4478: 4475: 4473: 4470: 4468: 4467:Ceruloplasmin 4465: 4461: 4458: 4457: 4456: 4453: 4451: 4448: 4446: 4442: 4439: 4438: 4435: 4429: 4426: 4425: 4423: 4420: 4416: 4413: 4409: 4399: 4396: 4394: 4391: 4389: 4386: 4384: 4381: 4380: 4378: 4375: 4371: 4363: 4360: 4358: 4355: 4354: 4353: 4349: 4346: 4344: 4340: 4337: 4335: 4332: 4330: 4327: 4326: 4324: 4321: 4317: 4314: 4312: 4309:Absorption in 4306: 4303: 4301: 4297: 4294: 4292: 4288: 4284: 4280: 4273: 4268: 4266: 4261: 4259: 4254: 4253: 4250: 4238: 4235: 4233: 4230: 4228: 4225: 4223: 4220: 4218: 4215: 4213: 4210: 4208: 4205: 4203: 4200: 4198: 4195: 4193: 4190: 4188: 4185: 4183: 4180: 4178: 4175: 4173: 4170: 4168: 4165: 4163: 4160: 4158: 4155: 4153: 4150: 4148: 4145: 4143: 4140: 4138: 4135: 4133: 4130: 4128: 4125: 4123: 4120: 4118: 4115: 4113: 4110: 4108: 4105: 4103: 4100: 4098: 4095: 4093: 4090: 4088: 4085: 4083: 4080: 4078: 4075: 4073: 4070: 4068: 4065: 4063: 4060: 4058: 4055: 4054: 4052: 4048: 4042: 4039: 4037: 4034: 4032: 4029: 4027: 4024: 4022: 4019: 4017: 4014: 4012: 4009: 4007: 4004: 4002: 3999: 3997: 3994: 3992: 3989: 3987: 3984: 3982: 3979: 3977: 3974: 3972: 3969: 3967: 3964: 3962: 3959: 3957: 3954: 3952: 3949: 3947: 3944: 3942: 3939: 3937: 3934: 3932: 3929: 3927: 3924: 3922: 3919: 3917: 3914: 3912: 3909: 3907: 3904: 3902: 3899: 3897: 3894: 3892: 3889: 3887: 3884: 3882: 3879: 3877: 3874: 3872: 3869: 3867: 3864: 3862: 3859: 3857: 3854: 3852: 3849: 3848: 3846: 3842: 3836: 3833: 3831: 3827: 3824: 3822: 3819: 3817: 3814: 3812: 3809: 3807: 3804: 3802: 3799: 3797: 3794: 3792: 3789: 3787: 3784: 3782: 3779: 3775: 3772: 3770: 3767: 3766: 3765: 3762: 3760: 3757: 3755: 3752: 3750: 3747: 3745: 3742: 3740: 3737: 3735: 3732: 3730: 3727: 3725: 3722: 3720: 3717: 3715: 3712: 3710: 3707: 3705: 3702: 3700: 3697: 3694: 3691: 3689: 3685: 3682: 3680: 3677: 3673: 3670: 3668: 3665: 3664: 3663: 3660: 3658: 3655: 3651: 3648: 3646: 3643: 3642: 3641: 3638: 3636: 3633: 3631: 3628: 3626: 3623: 3621: 3618: 3616: 3613: 3611: 3608: 3606: 3603: 3601: 3598: 3597: 3595: 3591: 3585: 3582: 3580: 3577: 3575: 3572: 3570: 3567: 3565: 3562: 3560: 3557: 3555: 3552: 3550: 3547: 3545: 3542: 3540: 3537: 3535: 3532: 3530: 3527: 3525: 3522: 3520: 3517: 3515: 3512: 3510: 3507: 3505: 3502: 3498: 3495: 3493: 3490: 3489: 3488: 3485: 3483: 3480: 3478: 3475: 3473: 3470: 3466: 3463: 3461: 3458: 3456: 3453: 3452: 3451: 3448: 3446: 3443: 3441: 3438: 3436: 3433: 3431: 3428: 3424: 3421: 3419: 3416: 3415: 3414: 3411: 3409: 3406: 3404: 3401: 3399: 3396: 3394: 3391: 3389: 3386: 3384: 3381: 3377: 3374: 3372: 3369: 3368: 3367: 3364: 3361: 3358: 3356: 3353: 3351: 3348: 3346: 3343: 3341: 3337: 3334: 3332: 3329: 3325: 3322: 3320: 3317: 3315: 3312: 3311: 3310: 3307: 3305: 3302: 3300: 3297: 3295: 3292: 3290: 3287: 3285: 3282: 3281: 3279: 3275: 3269: 3266: 3264: 3261: 3259: 3256: 3254: 3251: 3249: 3246: 3244: 3241: 3239: 3236: 3234: 3231: 3229: 3226: 3224: 3221: 3219: 3216: 3214: 3211: 3209: 3206: 3204: 3201: 3199: 3196: 3194: 3191: 3189: 3186: 3184: 3181: 3179: 3176: 3174: 3171: 3169: 3166: 3164: 3161: 3159: 3156: 3154: 3151: 3149: 3146: 3142: 3139: 3137: 3134: 3133: 3132: 3129: 3125: 3122: 3120: 3117: 3116: 3115: 3112: 3110: 3107: 3105: 3102: 3100: 3097: 3095: 3092: 3090: 3087: 3085: 3082: 3080: 3077: 3075: 3072: 3070: 3067: 3065: 3062: 3060: 3057: 3055: 3052: 3048: 3045: 3043: 3040: 3039: 3038: 3035: 3033: 3030: 3028: 3025: 3023: 3020: 3018: 3015: 3013: 3010: 3008: 3005: 3004: 3002: 2998: 2992: 2989: 2987: 2984: 2982: 2979: 2977: 2974: 2972: 2969: 2967: 2964: 2962: 2959: 2957: 2954: 2952: 2948: 2945: 2943: 2940: 2938: 2935: 2933: 2930: 2928: 2925: 2923: 2920: 2916: 2913: 2911: 2908: 2906: 2903: 2901: 2898: 2896: 2893: 2891: 2888: 2887: 2886: 2883: 2881: 2878: 2876: 2873: 2871: 2868: 2866: 2863: 2861: 2858: 2854: 2851: 2849: 2846: 2845: 2844: 2841: 2839: 2836: 2834: 2831: 2829: 2826: 2824: 2821: 2819: 2816: 2814: 2811: 2809: 2806: 2804: 2801: 2797: 2794: 2792: 2789: 2787: 2784: 2782: 2779: 2777: 2774: 2772: 2769: 2768: 2767: 2764: 2760: 2757: 2755: 2752: 2750: 2747: 2746: 2745: 2742: 2740: 2737: 2733: 2730: 2728: 2725: 2723: 2720: 2719: 2718: 2715: 2713: 2710: 2708: 2705: 2703: 2700: 2698: 2695: 2693: 2690: 2688: 2685: 2683: 2680: 2678: 2675: 2673: 2670: 2668: 2665: 2664: 2662: 2658: 2652: 2649: 2645: 2642: 2640: 2637: 2635: 2632: 2630: 2627: 2625: 2622: 2620: 2617: 2616: 2615: 2612: 2610: 2607: 2605: 2602: 2600: 2597: 2595: 2592: 2590: 2587: 2585: 2582: 2578: 2575: 2573: 2570: 2568: 2565: 2563: 2560: 2559: 2558: 2555: 2553: 2550: 2548: 2545: 2543: 2540: 2538: 2535: 2533: 2530: 2528: 2525: 2523: 2520: 2518: 2515: 2513: 2510: 2506: 2503: 2501: 2498: 2497: 2496: 2493: 2491: 2488: 2486: 2483: 2481: 2478: 2476: 2473: 2471: 2468: 2466: 2463: 2461: 2458: 2456: 2453: 2451: 2448: 2446: 2443: 2441: 2438: 2436: 2433: 2431: 2428: 2426: 2423: 2419: 2416: 2414: 2411: 2410: 2409: 2406: 2404: 2401: 2399: 2396: 2394: 2391: 2387: 2384: 2382: 2379: 2377: 2374: 2372: 2369: 2368: 2367: 2364: 2362: 2359: 2357: 2354: 2350: 2347: 2346: 2345: 2342: 2340: 2337: 2335: 2332: 2330: 2327: 2325: 2322: 2318: 2315: 2313: 2310: 2308: 2305: 2304: 2303: 2300: 2298: 2295: 2291: 2288: 2286: 2283: 2281: 2278: 2276: 2273: 2271: 2268: 2267: 2266: 2263: 2262: 2260: 2256: 2251: 2247: 2243: 2236: 2231: 2229: 2224: 2222: 2217: 2216: 2213: 2199: 2193: 2188: 2184: 2178: 2173: 2169: 2163: 2158: 2154: 2148: 2143: 2139: 2130: 2125: 2123: 2118: 2116: 2111: 2110: 2107: 2100: 2096: 2095: 2090: 2086: 2082: 2081: 2077: 2068: 2064: 2057: 2054: 2049: 2045: 2040: 2035: 2031: 2027: 2023: 2016: 2013: 2008: 2004: 1999: 1994: 1989: 1984: 1980: 1976: 1973:(4): 1472–7. 1972: 1968: 1964: 1957: 1954: 1949: 1945: 1941: 1937: 1932: 1927: 1923: 1919: 1912: 1905: 1902: 1897: 1893: 1889: 1885: 1881: 1877: 1873: 1869: 1862: 1859: 1854: 1850: 1845: 1840: 1836: 1832: 1828: 1821: 1818: 1813: 1809: 1805: 1801: 1794: 1791: 1786: 1782: 1778: 1774: 1767: 1764: 1759: 1755: 1751: 1747: 1743: 1739: 1735: 1731: 1724: 1717: 1714: 1709: 1705: 1701: 1697: 1693: 1689: 1685: 1681: 1674: 1671: 1666: 1662: 1658: 1654: 1647: 1644: 1639: 1635: 1631: 1627: 1623: 1619: 1612: 1609: 1604: 1600: 1595: 1590: 1587:(6): 1112–6. 1586: 1582: 1578: 1571: 1568: 1563: 1559: 1554: 1549: 1544: 1539: 1535: 1531: 1528:(7): 4515–9. 1527: 1523: 1519: 1512: 1509: 1504: 1500: 1494: 1491: 1486: 1482: 1476: 1473: 1469: 1465: 1460: 1458: 1456: 1452: 1448: 1444: 1439: 1437: 1435: 1431: 1424: 1420: 1417: 1415: 1412: 1411: 1407: 1405: 1402: 1394: 1392: 1390: 1386: 1382: 1374: 1372: 1370: 1366: 1361: 1357: 1353: 1349: 1345: 1341: 1337: 1333: 1328: 1321: 1319: 1317: 1309: 1304: 1297: 1295: 1293: 1289: 1285: 1282: 1278: 1274: 1270: 1266: 1262: 1258: 1254: 1242: 1237: 1233: 1229: 1226: 1222: 1215: 1213: 1210: 1206: 1202: 1198: 1195: 1191: 1187: 1180: 1178: 1174: 1168: 1164: 1161: 1155: 1153: 1149: 1145: 1141: 1135: 1131: 1128: 1124: 1117: 1115: 1111: 1105: 1101: 1098: 1092: 1090: 1086: 1082: 1078: 1072: 1068: 1065: 1063:RefSeq (mRNA) 1061: 1054: 1053: 1048: 1044: 1041: 1035: 1034: 1029: 1025: 1022: 1020: 1016: 1009: 1008: 1003: 999: 996: 990: 989: 984: 980: 977: 975: 971: 964: 963: 958: 954: 951: 945: 944: 939: 935: 932: 930: 926: 923: 920: 918: 915: 911: 908: 904: 900: 893: 889: 884: 878: 875: 873: 870: 868: 865: 863: 860: 858: 855: 853: 850: 848: 845: 843: 840: 838: 835: 833: 832:viral process 830: 828: 825: 823: 820: 818: 815: 813: 810: 808: 805: 803: 800: 798: 795: 794: 792: 789: 788: 782: 779: 777: 774: 772: 769: 767: 764: 762: 759: 757: 754: 752: 749: 747: 744: 742: 739: 737: 734: 732: 729: 727: 724: 722: 719: 717: 714: 712: 709: 707: 704: 702: 699: 697: 694: 692: 689: 687: 684: 682: 679: 677: 674: 673: 671: 668: 667: 661: 658: 656: 653: 651: 648: 646: 643: 641: 638: 636: 633: 631: 628: 627: 625: 622: 621: 618: 617:Gene ontology 614: 610: 598: 593: 589: 582: 577: 574: 572: 568: 560: 555: 544: 540: 536: 532: 528: 524: 520: 516: 513:body of femur 512: 508: 507: 504: 500: 495: 492: 482: 478: 474: 470: 467:hair follicle 466: 462: 458: 454: 450: 446: 445: 442: 438: 433: 430: 429: 426: 424: 420: 418: 417: 413: 412: 409: 407: 403: 399: 395: 391: 383: 378: 374: 370: 365: 355: 351: 344: 337: 331: 324: 316: 312: 308: 303: 299: 294: 290: 282: 277: 273: 269: 264: 254: 250: 243: 236: 230: 223: 219: 213: 209: 205: 200: 196: 191: 187: 183: 179: 175: 171: 167: 163: 159: 155: 151: 147: 139: 134: 127: 122: 117: 106: 104: 100: 96: 92: 88: 84: 80: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 4748:Transferrins 4688:expanding it 4677: 3763: 3683: 3661: 3639: 3486: 3449: 3412: 3365: 3335: 3308: 3130: 3036: 2884: 2613: 2365: 2197: 2182: 2167: 2152: 2092: 2066: 2056: 2029: 2025: 2015: 1970: 1966: 1956: 1921: 1918:FEBS Letters 1917: 1904: 1871: 1867: 1861: 1837:(1): 49–60. 1834: 1830: 1820: 1803: 1799: 1793: 1779:(1): 66–70. 1776: 1772: 1766: 1733: 1729: 1716: 1683: 1679: 1673: 1656: 1652: 1646: 1621: 1617: 1611: 1584: 1580: 1570: 1525: 1521: 1511: 1502: 1493: 1484: 1475: 1398: 1378: 1375:Interactions 1329: 1325: 1313: 1280: 1272: 1268: 1264: 1260: 1256: 1252: 1251: 1177:NP_001344227 1170: 1148:NP_001300895 1144:NP_001300894 1140:NP_001121620 1137: 1114:NM_001357298 1107: 1085:NM_001128148 1081:NM_001313966 1077:NM_001313965 1074: 1050: 1031: 1005: 986: 960: 941: 921: 916: 731:cell surface 421: 414: 279:196,082,096 266:196,027,183 141:External IDs 72: 4592:Na/K-ATPase 4575:Electrolyte 4482:Lactoferrin 4477:Hemosiderin 4450:Hemojuvelin 4348:Transferrin 2135:PDB gallery 1316:transferrin 1292:endocytosis 1288:transferrin 797:endocytosis 655:RNA binding 533:human fetus 483:bone marrow 380:32,451,612 367:32,427,738 119:Identifiers 4727:Categories 4339:Hephaestin 4279:Metabolism 2248:(see also 1736:: 101665. 1470:, May 2017 1449:, May 2017 1425:References 1352:antibodies 1344:antibodies 1263:luster of 711:melanosome 425:(ortholog) 162:HomoloGene 4460:Aconitase 1758:199405122 1346:into the 1173:NP_035768 1152:NP_003225 1110:NM_011638 1089:NM_003234 907:Orthologs 170:GeneCards 4441:Hepcidin 4428:Ferritin 4398:Ferritin 4388:Integrin 4334:Ferritin 4311:duodenum 2242:Proteins 2048:11027676 1948:29391940 1940:11997026 1896:34161824 1888:21613623 1853:24411731 1812:10688622 1750:31376426 1708:25425279 1700:21391831 1665:12553165 1638:15313461 1466:– 1445:– 1408:See also 1381:interact 1369:lysosome 1360:affinity 1275:), is a 1225:Wikidata 886:Sources: 706:membrane 696:endosome 517:habenula 4561:SLC39A4 4556:SLC30A1 4523:SLC31A1 4050:301–350 3844:251–300 3796:CD240CE 3593:201–250 3277:151–200 3000:101–150 2099:PDBe-KB 2089:UniProt 2007:9465039 1975:Bibcode 1785:1920136 1603:3002171 1594:1684729 1562:6270680 1530:Bibcode 1468:Ensembl 1447:Ensembl 1385:GABARAP 1365:Avidity 1334:of the 1277:protein 1019:UniProt 974:Ensembl 913:Species 892:QuickGO 400:pattern 126:Aliases 4057:CD300A 4016:CDw293 3801:CD240D 3662:CD213a 3640:CDw210 3605:CD202b 3579:CDw199 3574:CDw198 3228:CD140b 2660:51–100 2094:P02786 2063:"CD71" 2046:  2005:  1995:  1946:  1938:  1894:  1886:  1851:  1831:Neuron 1810:  1783:  1756:  1748:  1706:  1698:  1663:  1636:  1601:  1591:  1560:  1553:319822 1550:  1211:search 1209:PubMed 1052:Q62351 1033:P02786 929:Entrez 571:BioGPS 150:190010 4678:This 4528:ATOX1 4513:ATP7B 4508:ATP7A 4411:Other 4237:CD350 4232:CD349 4227:CD344 4222:CD340 4217:CD339 4212:CD338 4207:CD337 4202:CD336 4197:CD335 4192:CD334 4187:CD333 4182:CD332 4177:CD331 4172:CD329 4167:CD328 4162:CD327 4157:CD326 4152:CD325 4147:CD324 4142:CD322 4137:CD321 4132:CD320 4127:CD318 4122:CD317 4117:CD316 4112:CD315 4107:CD314 4102:CD312 4097:CD309 4092:CD307 4087:CD306 4082:CD305 4077:CD304 4072:CD303 4067:CD302 4062:CD301 4041:CD299 4036:CD298 4031:CD297 4026:CD295 4021:CD294 4011:CD292 4006:CD290 4001:CD289 3996:CD288 3991:CD286 3986:CD284 3981:CD283 3976:CD282 3971:CD281 3966:CD280 3961:CD279 3956:CD278 3951:CD276 3946:CD275 3941:CD274 3936:CD273 3931:CD272 3926:CD271 3921:CD269 3916:CD268 3911:CD267 3906:CD266 3901:CD265 3896:CD264 3891:CD263 3886:CD262 3881:CD261 3876:CD258 3871:CD257 3866:CD256 3861:CD254 3856:CD253 3851:CD252 3835:CD249 3830:CD248 3826:CD247 3821:CD246 3816:CD244 3811:CD243 3806:CD241 3791:CD239 3786:CD238 3781:CD236 3764:CD235 3759:CD234 3754:CD233 3749:CD230 3744:CD229 3739:CD228 3734:CD227 3729:CD226 3724:CD225 3719:CD224 3714:CD223 3709:CD222 3704:CD221 3699:CD220 3684:CD218 3679:CD217 3657:CD212 3635:CD209 3630:CD208 3625:CD207 3620:CD206 3615:CD205 3610:CD204 3600:CD201 3584:CD200 3569:CD197 3564:CD196 3559:CD195 3554:CD194 3549:CD193 3544:CD192 3539:CD191 3534:CD186 3529:CD185 3524:CD184 3519:CD183 3514:CD182 3509:CD181 3504:CD180 3487:CD179 3482:CD178 3477:CD177 3472:CD174 3450:CD172 3445:CD171 3440:CD170 3435:CD169 3430:CD168 3413:CD167 3408:CD166 3403:CD164 3398:CD163 3393:CD162 3388:CD161 3383:CD160 3366:CD159 3336:CD158 3331:CD157 3309:CD156 3304:CD155 3299:CD154 3294:CD153 3289:CD152 3284:CD151 3268:CD150 3263:CD148 3258:CD147 3253:CD146 3248:CD144 3243:CD143 3238:CD142 3233:CD141 3223:CD138 3218:CD137 3213:CD136 3208:CD135 3203:CD134 3198:CD133 3193:CD132 3188:CD131 3183:CD130 3178:CD129 3173:CD127 3168:CD126 3163:CD125 3158:CD124 3153:CD123 3148:CD122 3131:CD121 3114:CD120 3109:CD119 3104:CD118 3099:CD117 3094:CD116 3089:CD115 3084:CD114 3079:CD113 3074:CD112 3069:CD111 3064:CD110 3059:CD109 3054:CD108 3037:CD107 3032:CD106 3027:CD105 3022:CD104 3017:CD103 3012:CD102 3007:CD101 2991:CD100 1998:19050 1944:S2CID 1914:(PDF) 1892:S2CID 1754:S2CID 1726:(PDF) 1704:S2CID 1383:with 1348:brain 962:22042 922:Mouse 917:Human 888:Amigo 545:ankle 455:tibia 423:Mouse 416:Human 363:Start 298:Mouse 262:Start 195:Human 158:98822 4684:stub 4551:TMC8 4546:TMC6 4445:HAMP 4362:TFR2 4357:TFR1 2986:CD99 2981:CD98 2976:CD97 2971:CD96 2966:CD95 2961:CD94 2956:CD93 2951:CD92 2947:CD91 2942:CD90 2937:CD89 2932:CD88 2927:CD87 2922:CD86 2885:CD85 2880:CD84 2875:CD83 2870:CD82 2865:CD81 2860:CD80 2843:CD79 2838:CD78 2833:CD74 2828:CD73 2823:CD72 2818:CD71 2813:CD70 2808:CD69 2803:CD68 2766:CD66 2744:CD64 2739:CD63 2717:CD62 2712:CD61 2707:CD59 2702:CD58 2697:CD57 2692:CD56 2687:CD55 2682:CD54 2677:CD53 2672:CD52 2667:CD51 2651:CD50 2614:CD49 2609:CD48 2604:CD47 2599:CD46 2594:CD45 2589:CD44 2584:CD43 2557:CD42 2552:CD41 2547:CD40 2542:CD39 2537:CD38 2532:CD37 2527:CD36 2522:CD35 2517:CD34 2512:CD33 2495:CD32 2490:CD31 2485:CD30 2480:CD29 2475:CD28 2470:CD27 2465:CD26 2460:CD25 2455:CD24 2450:CD23 2445:CD22 2440:CD21 2435:CD20 2430:CD19 2425:CD18 2408:CD16 2403:CD15 2398:CD14 2393:CD13 2366:CD11 2361:CD10 2258:1–50 2198:2nsu 2183:1suv 2168:1de4 2153:1cx8 2087:for 2044:PMID 2003:PMID 1936:PMID 1884:PMID 1849:PMID 1808:PMID 1781:PMID 1746:PMID 1696:PMID 1661:PMID 1634:PMID 1599:PMID 1558:PMID 1387:and 1284:gene 1281:TFRC 1273:CD71 1257:TfR1 943:7037 406:Bgee 354:Band 315:Chr. 258:3q29 253:Band 212:Chr. 174:TFRC 166:2429 146:OMIM 133:TFRC 103:3S9N 99:3S9M 95:3S9L 91:3KAS 87:2NSU 83:1SUV 79:1DE4 75:1CX8 56:RCSB 53:PDBe 22:TFRC 4472:HFE 4350:to 2356:CD9 2344:CD8 2339:CD7 2334:CD6 2329:CD5 2324:CD4 2302:CD3 2297:CD2 2270:a-c 2265:CD1 2085:PDB 2034:doi 2030:275 1993:PMC 1983:doi 1926:doi 1922:518 1876:doi 1839:doi 1804:292 1777:259 1738:doi 1734:181 1688:doi 1626:doi 1589:PMC 1548:PMC 1538:doi 1389:HFE 376:End 275:End 178:OMA 154:MGI 46:PDB 4729:: 4281:: 3828:- 2949:- 2290:1E 2285:1D 2280:1B 2275:1A 2244:: 2091:: 2065:. 2042:. 2028:. 2024:. 2001:. 1991:. 1981:. 1971:95 1969:. 1965:. 1942:. 1934:. 1920:. 1916:. 1890:. 1882:. 1870:. 1847:. 1835:81 1833:. 1829:. 1802:. 1775:. 1752:. 1744:. 1732:. 1728:. 1702:. 1694:. 1684:47 1682:. 1657:49 1655:. 1632:. 1622:36 1620:. 1597:. 1585:37 1583:. 1579:. 1556:. 1546:. 1536:. 1526:78 1524:. 1520:. 1501:. 1483:. 1454:^ 1433:^ 1391:. 1294:. 1269:71 890:/ 382:bp 369:bp 281:bp 268:bp 176:; 172:: 168:; 164:: 160:; 156:: 152:; 148:: 101:, 97:, 93:, 89:, 85:, 81:, 77:, 4715:e 4708:t 4701:v 4690:. 4443:/ 4421:: 4376:: 4341:/ 4322:: 4271:e 4264:t 4257:v 3774:b 3769:a 3695:) 3693:b 3688:a 3686:( 3672:2 3667:1 3650:b 3645:a 3497:b 3492:a 3465:g 3460:b 3455:a 3423:b 3418:a 3376:c 3371:a 3362:) 3360:k 3355:i 3350:e 3345:d 3340:a 3338:( 3324:c 3319:b 3314:a 3141:b 3136:a 3124:b 3119:a 3047:b 3042:a 2915:k 2910:j 2905:h 2900:e 2895:d 2890:a 2853:b 2848:a 2796:f 2791:e 2786:d 2781:c 2776:b 2771:a 2759:C 2754:B 2749:A 2732:P 2727:L 2722:E 2644:f 2639:e 2634:d 2629:c 2624:b 2619:a 2577:d 2572:c 2567:b 2562:a 2505:B 2500:A 2418:B 2413:A 2386:d 2381:c 2376:b 2371:a 2349:a 2317:ε 2312:δ 2307:γ 2252:) 2234:e 2227:t 2220:v 2128:e 2121:t 2114:v 2101:. 2069:. 2050:. 2036:: 2009:. 1985:: 1977:: 1950:. 1928:: 1898:. 1878:: 1872:3 1855:. 1841:: 1814:. 1787:. 1760:. 1740:: 1710:. 1690:: 1667:. 1640:. 1628:: 1605:. 1564:. 1540:: 1532:: 1505:. 1487:. 1310:. 1271:( 1265:D 1261:C 1255:( 300:) 197:) 180::

Index


PDB
PDBe
RCSB
1CX8
1DE4
1SUV
2NSU
3KAS
3S9L
3S9M
3S9N
Aliases
TFRC
OMIM
190010
MGI
98822
HomoloGene
2429
GeneCards
TFRC
OMA
TFRC - orthologs
Human
Chromosome 3 (human)
Chr.
Chromosome 3 (human)
Chromosome 3 (human)
Genomic location for TFRC

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