310:
287:
1650:
potency, species specificity and mechanism of inhibition. While the earliest inhibitors, such as HC-030031, were lower potency (micromolar inhibition) and had limited TRPA1 specificity, the more recent discovery of highly potent inhibitors with low nanomolar inhibition constants, such as A-967079 and ALGX-2542 as well as high selectivity among other members the TRP superfamily and lack of interaction with other targets have provided valuable tool compounds and candidates for future drug development.
184:
209:
1673:(SPMs) class of metabolites that function to resolve diverse inflammatory reactions and diseases in animal models and, it is proposed, in humans. These SPMs also damp pain perception arising from various inflammation-based causes in animal models. The mechanism behind their pain-dampening effect involves the inhibition of TRPA1, probably (in at least certain cases) by an indirect effect wherein they activate another receptor located on neurons or nearby
568:
561:
316:
215:
1296:). Most notably, the site of covalent modification and activation for electrophilic irritants was localized to a tertiary structural feature on the membrane-proximal intracellular face of the channel, which has been termed the 'allosteric nexus', and which is composed of a cysteine-rich linker domain and the eponymous TRP domain. Breakthrough research combining cryo-electron microscopy and
1649:
A number of small molecule inhibitors (antagonists) have been discovered which have been shown to block the function of TRPA1. At the cellular level, assays that measure agonist-activated inhibition of TRPA1-mediated calcium fluxes and electrophysiological assays have been used to characterize the
1309:
activation by the second messenger calcium, the structure of the channel in complex with calcium localized the binding site for this ion and functional studies demonstrated that this site controls the various different effects of calcium on the channel – namely potentiation, desensitization, and
1178:
and is believed to function as a mechanical and chemical stress sensor. One of the specific functions of this protein studies involves a role in the detection, integration and initiation of pain signals in the peripheral nervous system. It can be activated at sites of tissue injury or sites of
1357:
Oxalate, a metabolite of an anti cancer drug oxaliplatin, has been demonstrated to inhibit prolyl hydroxylase, which endows cold-insensitive human TRPA1 with pseudo cold sensitivity (via reactive oxygen generation from mitochondria). This may cause a characteristic side-effect of oxaliplatin
1308:
act step-wise to modify two critical cysteine residues in the allosteric nexus. Upon covalent attachment, the allosteric nexus adopts a conformational change that is propagated to the channel's pore, dilating it to permit cation influx and subsequent cellular depolarization. With respect to
1161:
located on the plasma membrane of many human and animal cells. This ion channel is best known as a sensor for pain, cold and itch in humans and other mammals, as well as a sensor for environmental irritants giving rise to other protective responses (tears, airway resistance, and cough).
63:
1321:
In 2008, it was observed that caffeine suppresses activity of human TRPA1, but it was found that mouse TRPA1 channels expressed in sensory neurons cause an aversion to drinking caffeine-containing water, suggesting that the TRPA1 channels mediate the perception of caffeine.
3773:
Gijsen HJ, Berthelot D, Zaja M, Brône B, Geuens I, Mercken M (October 2010). "Analogues of morphanthridine and the tear gas dibenzoxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel".
1325:
TRPA1 has also been implicated in airway irritation by cigarette smoke, cleaning supplies and in the skin irritation experienced by some smokers trying to quit by using nicotine replacement therapies such as inhalers, sprays, or patches. A
2573:
4049:
Grilo A, Sáez-Rosas MP, Santos-Morano J, Sánchez E, Moreno-Rey C, Real LM, et al. (January 2011). "Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough".
1246:. TRPA1 knockout mice showed near complete attenuation of nocifensive behaviors to formalin, tear-gas and other reactive chemicals . TRPA1 antagonists are effective in blocking pain behaviors induced by inflammation (complete
6762:
1334:
suffers from debilitating upper-body pain starting in infancy that is usually triggered by fasting or fatigue (illness, cold temperature, and physical exertion being contributory factors). A gain-of-function
2487:
Ryckmans T, Aubdool AA, Bodkin JV, Cox P, Brain SD, Dupont T, et al. (August 2011). "Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel".
1641:) was discovered; it was shown to bind TRPA1 non-covalently in the same region as electrophiles and act as a gating modifier toxin for the receptor, stabilizing the channel in an open conformation.
6755:
2048:
Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of
Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels".
1366:
TRPA1 can be considered to be one of the most promiscuous TRP ion channels, as it seems to be activated by a large number of noxious chemicals found in many plants, food, cosmetics and pollutants.
1419:
and TRPA1 activation. A dibenzoxazepine derivative substituted by a carboxylic methyl ester at position 10 has been reported to be a potent nonelectrophilic (thiol-unreactive) TRPA1 agonist (EC
3663:
Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A (February 2007). "Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines".
6748:
2243:
Baraldi PG, Preti D, Materazzi S, Geppetti P (July 2010). "Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents".
1253:
Although it is not fully confirmed whether noxious cold sensation is mediated by TRPA1 in vivo, several recent studies clearly demonstrated cold activation of TRPA1 channels in vitro.
5303:
6213:
1179:
inflammation directly by endogenous mediators or indirectly as a downstream target via signaling from a number of distinct G-protein coupled receptors (GPCRs), such as bradykinin.
5948:
5200:
5133:
2278:
Brône B, Peeters PJ, Marrannes R, Mercken M, Nuydens R, Meert T, Gijsen HJ (September 2008). "Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor".
1443:
enabling membrane permeation result in a potent TRPA1 agonistic effect, but thiol adduct formation is neither sufficient nor necessary for TRPA1 activation. The pyrimidine
323:
222:
1620:
responses. Its mechanism of action does not appear to involve direct binding to TRPA1 but rather the indirect activation and/or sensitization of TRPA1 as well as
1570:
responses of mice to skin inflammation. In this animal model of pain perception, the hepoxilins are released in the spinal cord directly activate TRPA (and also
4216:
Pryde DC, Marron B, West CG, Reister S, Amato G, Yoger K, et al. (2016-11-08). "The discovery of a potent series of carboxamide TRPA1 antagonists".
856:
3870:"Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia"
837:
145:
4000:
6144:
6127:
6122:
6117:
6112:
4152:"Novel TRPA1 Antagonists are Multimodal Blockers of Human TRPA1 Channels: Drug Candidates for Treatment of Familial Episodic Pain Syndrome (FEPS)"
2621:"Dose-response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation"
2574:"Psychophysical and vasomotor evidence for interdependency of TRPA1 and TRPV1-evoked nociceptive responses in human skin: an experimental study"
6149:
5247:
4519:
1986:
7777:
7743:
3438:
2205:
1293:
1968:
8612:
6771:
6201:
5382:
1439:(10 nM) 'gases') were found to be thiol-reactive TRPA1 agonists. This study found that chemical reactivity with thiols in combination with
1171:
1578:-HpETE, which is the direct precursor to HxA3 and HxB3 in the ALOX12 pathway, may act only after being converted to these hepoxilins. The
60:
8514:
7630:
7370:
6099:
5120:
4536:
1354:
does in the spinal cord of mice, causing an antinociceptive effect. This is suggested as the antinociceptive mechanism for paracetamol.
309:
5885:
1670:
1064:
2814:"Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists"
1310:
1071:
3219:"Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents"
286:
8469:
7605:
7340:
3811:"Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors"
3554:"Sensory characterization of the irritant properties of oleocanthal, a natural anti-inflammatory agent in extra virgin olive oils"
2229:
8592:
7905:
6478:
5477:
5255:
4571:
1955:
1934:
1771:
1523:
3505:"Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal"
8479:
7900:
7895:
7345:
6500:
2323:"Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases"
2006:"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts"
1300:
later elucidated the molecular mechanism of how the channel functions as a broad-spectrum irritant detector. With respect to
1951:
208:
183:
7880:
7875:
6822:
6709:
4620:
1273:
1930:
8588:
7865:
7426:
6075:
4987:
1304:, which activate the channel by covalent modification of two cysteines in the allosteric nexus, it was shown that these
125:
6350:
2769:
Sawada Y, Hosokawa H, Hori A, Matsumura K, Kobayashi S (July 2007). "Cold sensitivity of recombinant TRPA1 channels".
1495:
1350:(acetaminophen) have been demonstrated to bind to the TRPA1 receptors, which may desensitize the receptors in the way
17:
4193:
A Novel Class of Potent, Allosteric TRPA1 Antagonists
Reverse Hyperalgesia in Multiple Rat Models of Neuropathic Pain
322:
221:
8617:
4528:
4512:
1613:
1610:
1455:= 97 nM) TRPA1 channels. This compound elicits nociception in a mouse model through TRPA1 activation. Furthermore,
1261:
8230:
1276:
was employed to obtain a three-dimensional structure of TRPA1. This work revealed that the channel assembles as a
315:
214:
6994:
6704:
4914:
1861:
3503:
Peyrot des
Gachons C, Uchida K, Bryant B, Shima A, Sperry JB, Dankulich-Nagrudny L, et al. (January 2011).
3317:"TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol"
7980:
7890:
7885:
7870:
7687:
7187:
6817:
6812:
6694:
4955:
4831:
4491:
3716:"The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors"
1796:
1599:
901:
133:
8171:
7953:
6699:
1821:
1305:
1281:
882:
2863:
Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, et al. (April 2010).
8474:
8321:
8038:
7910:
7816:
7182:
6827:
6730:
4722:
4709:
4696:
4676:
4663:
4628:
2922:"Molecular Evolution of the Infrared Sensory Gene TRPA1 in Snakes and Implications for Functional Studies"
1856:
1811:
1280:, and possesses several structural features that hint at its complex regulation by irritants, cytoplasmic
3366:"Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS"
8622:
8149:
7948:
7233:
6967:
4505:
1873:
1826:
1632:
1463:, the pungent component of mustard oil, for screening purposes. Other TRPA1 channel activators include
8176:
3809:
Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, et al. (April 2012).
8529:
8350:
8292:
8221:
8129:
8082:
7517:
7380:
7318:
7298:
7172:
6860:
4603:
3924:
Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A (January 2014).
3822:
3672:
3614:
3377:
3328:
3122:
3057:
3000:
2933:
2876:
2682:
2669:
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, et al. (August 2007).
2287:
1725:
1666:
1605:
Studies with mice, guinea pigs, and human tissues indicate that another arachidonic acid metabolite,
1460:
1380:
appears to be responsible for the pungent or "peppery" sensation in the back of the throat caused by
1340:
1247:
1183:
197:
3315:
Andersson DA, Gentry C, Alenmyr L, Killander D, Lewis SE, Andersson A, et al. (November 2011).
2620:
8434:
8354:
8296:
8254:
8196:
7964:
7472:
7143:
4497:
4243:
Qu Q, Xuan W, Fan GH (January 2015). "Roles of resolvins in the resolution of acute inflammation".
2427:
Talavera K, Gees M, Karashima Y, Meseguer VM, Vanoirbeek JA, Damann N, et al. (October 2009).
1846:
1436:
1227:
1047:
996:
112:
7477:
4487:
4096:
Lin King JV, Emrick JJ, Kelly MJ, Herzig V, King GF, Medzihradszky KF, Julius D (September 2019).
8559:
8419:
8315:
8181:
7976:
7922:
7487:
7431:
7360:
7161:
7053:
6839:
6786:
6070:
4946:
4593:
4268:
4173:
4075:
3696:
3456:"Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures"
3091:
2794:
2651:
2601:
2466:
2170:
2073:
1831:
1662:
1637:
1285:
157:
7610:
1594:-eicosatrienoic acid (5,6-EET) made by the metabolism of arachidonic acid by any one of several
1399:
chemicals that have been shown to activate the TRPA1 receptor via the formation of a reversible
1043:
1022:
992:
971:
8414:
8275:
7670:
7569:
7522:
7452:
8519:
8509:
8032:
7620:
7543:
7534:
7365:
7134:
7089:
7079:
7024:
6977:
6777:
5108:
4466:
4437:"The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution"
4417:
4368:
4317:
4260:
4127:
4067:
4031:
3982:
3947:
3901:
3850:
3791:
3755:
3737:
3688:
3642:
3583:
3534:
3485:
3434:
3403:
3346:
3297:
3248:
3199:
3150:
3083:
3026:
2969:
2951:
2902:
2845:
2786:
2751:
2710:
2643:
2593:
2554:
2505:
2458:
2406:
2354:
2303:
2260:
2211:
2201:
2162:
2117:
2065:
2027:
1428:
1327:
1297:
1243:
1195:
567:
105:
53:
8534:
4014:
Maher SA, Dubuis ED, Belvisi MG (June 2011). "G-protein coupled receptors regulating cough".
8444:
8210:
8048:
7512:
7457:
7118:
6802:
5877:
4858:
4456:
4448:
4407:
4399:
4358:
4348:
4307:
4299:
4252:
4225:
4196:
4163:
4117:
4109:
4059:
4023:
3974:
3937:
3891:
3881:
3868:
Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, et al. (May 2013).
3840:
3830:
3783:
3745:
3727:
3680:
3632:
3622:
3573:
3565:
3524:
3516:
3475:
3467:
3426:
3393:
3385:
3336:
3287:
3279:
3238:
3230:
3189:
3181:
3140:
3130:
3073:
3065:
3016:
3008:
2959:
2941:
2892:
2884:
2835:
2825:
2778:
2741:
2700:
2690:
2635:
2585:
2544:
2536:
2497:
2448:
2440:
2396:
2388:
2344:
2334:
2295:
2252:
2193:
2154:
2107:
2057:
2017:
1851:
1606:
1199:
402:
333:
277:
232:
7751:
7723:
3714:
Fischer MJ, Leffler A, Niedermirtl F, Kistner K, Eberhardt M, Reeh PW, Nau C (2010-11-05).
1624:
receptors. Genetic polymorphism in the EP3 receptor (rs11209716), has been associated with
560:
153:
8564:
8484:
8287:
8280:
7682:
7675:
7615:
7527:
7395:
7390:
7350:
6897:
6807:
6413:
4553:
3425:. Topics in Medicinal Chemistry. Vol. 23. Springer Berlin Heidelberg. pp. 1–41.
1740:
1715:
1595:
377:
4201:
3217:
Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, et al. (July 2008).
1330:
of TRPA1 was found to be the cause of a hereditary episodic pain syndrome. A family from
1230:
in humans. This sub-population of peripheral C-fibers is considered important sensors of
3826:
3676:
3618:
3381:
3332:
3170:"Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control"
3126:
3061:
3004:
2937:
2880:
2686:
2291:
8311:
8226:
7996:
7918:
7625:
7157:
7064:
7034:
6927:
6835:
6209:
4896:
4461:
4436:
4412:
4387:
4363:
4336:
4312:
4287:
4122:
4097:
3896:
3869:
3845:
3810:
3750:
3715:
3637:
3602:
3578:
3553:
3529:
3504:
3480:
3455:
3398:
3365:
3292:
3267:
3243:
3218:
3194:
3169:
3145:
3110:
3078:
3045:
3021:
2988:
2964:
2921:
2897:
2864:
2840:
2813:
2705:
2670:
2549:
2524:
2401:
2376:
2349:
2322:
2230:"Entrez Gene: TRPA1 transient receptor potential cation channel, subfamily A, member 1"
1836:
1801:
1373:
1187:
1175:
116:, ANKTM1, FEPS, transient receptor potential cation channel subfamily A member 1, FEPS1
4098:"A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain"
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
670:
665:
660:
655:
650:
634:
629:
624:
619:
614:
609:
8606:
8544:
8524:
8119:
7834:
7665:
7645:
7375:
7263:
7074:
6947:
6864:
6163:
5836:
4177:
3364:
Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, et al. (September 2016).
3095:
2812:
Klionsky L, Tamir R, Gao B, Wang W, Immke DC, Nishimura N, Gavva NR (December 2007).
2428:
1698:
1694:
1625:
1440:
1415:, which is known to cause pain on injection into a vein, a side effect attributed to
1396:
1289:
1219:
596:
4272:
4168:
4151:
4079:
3266:
Kremeyer B, Lopera F, Cox JJ, Momin A, Rugiero F, Marsh S, et al. (June 2010).
2798:
2655:
2639:
2605:
2589:
2174:
2138:
Højland CR, Andersen HH, Poulsen JN, Arendt-Nielsen L, Gazerani P (September 2015).
2077:
137:
8424:
8240:
8200:
8133:
8123:
8114:
8109:
8052:
8010:
7600:
7385:
7294:
7207:
7019:
7014:
6917:
6516:
5907:
3700:
3520:
2782:
2540:
2470:
1841:
1563:
1301:
1277:
395:
174:
2140:"A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde"
4063:
3978:
3283:
2946:
2321:
Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE (April 2009).
2197:
161:
8464:
8392:
8376:
8244:
8216:
8099:
8043:
7986:
7972:
7660:
7655:
7595:
7324:
7309:
7304:
7258:
7197:
7124:
7104:
7083:
7044:
6907:
6872:
6446:
6441:
6436:
6431:
6318:
6157:
4532:
4337:"Biological Roles of Resolvins and Related Substances in the Resolution of Pain"
4303:
1991:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1973:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1735:
1487:
1408:
1377:
1347:
1231:
1158:
4452:
4403:
4113:
4027:
3815:
Proceedings of the
National Academy of Sciences of the United States of America
3607:
Proceedings of the
National Academy of Sciences of the United States of America
3185:
3115:
Proceedings of the
National Academy of Sciences of the United States of America
2746:
2729:
2675:
Proceedings of the
National Academy of Sciences of the United States of America
2501:
2299:
2139:
478:
8454:
8345:
8260:
8250:
8206:
8190:
8186:
8077:
7943:
7811:
7692:
7538:
7466:
7462:
7355:
7314:
7139:
7129:
7114:
6982:
6892:
6426:
5792:
5160:
5128:
3471:
3069:
1816:
1806:
1755:
1456:
1444:
1257:
1215:
294:
191:
141:
3741:
3268:"A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome"
3111:"Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels"
2955:
8569:
8554:
8549:
8499:
8494:
8139:
8058:
8016:
8006:
7243:
7108:
6511:
6421:
3835:
3732:
3627:
3569:
3135:
2695:
2022:
2005:
1765:
1678:
1674:
1654:
1567:
1559:
1476:
1381:
1370:
1351:
801:
538:
416:
361:
348:
260:
247:
149:
4470:
4421:
4372:
4321:
4264:
4131:
4071:
4035:
3986:
3951:
3905:
3854:
3795:
3759:
3692:
3646:
3587:
3538:
3489:
3407:
3350:
3301:
3252:
3203:
3154:
3087:
3030:
2973:
2906:
2849:
2830:
2790:
2755:
2714:
2647:
2597:
2558:
2509:
2462:
2410:
2375:
Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE (May 2008).
2358:
2307:
2264:
2215:
2166:
2121:
2069:
2031:
4353:
3967:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
2619:
Andersen HH, Lo Vecchio S, Gazerani P, Arendt-Nielsen L (September 2017).
2158:
2112:
2095:
1182:
Recent studies indicate that TRPA1 is activated by a number of reactive (
1111:
1106:
8504:
8489:
8458:
8448:
8438:
8428:
8409:
8397:
8366:
8361:
8325:
8236:
8089:
8028:
8000:
7990:
7968:
7650:
7635:
7559:
7497:
7482:
7442:
7248:
7223:
7176:
7167:
7094:
7060:
7004:
6999:
6961:
6957:
6931:
6921:
6911:
6901:
6887:
6845:
6740:
6524:
5872:
4851:
4846:
4841:
4836:
4768:
4763:
3886:
3430:
3046:"Irritant-evoked activation and calcium modulation of the TRPA1 receptor"
2339:
2192:. Handbook of Experimental Pharmacology. Vol. 179. pp. 347–62.
1891:
1760:
1745:
1730:
1697:
have been proposed to be the receptors through which SPMs may operate to
1472:
1468:
1412:
1404:
1400:
1343:
causes the channel to be overly sensitive to pharmacological activation.
1336:
1331:
1211:
1207:
1203:
1191:
1095:
946:
927:
4388:"Emerging roles of resolvins in the resolution of inflammation and pain"
3684:
3389:
3012:
2888:
8539:
8404:
8370:
8339:
8303:
8161:
8143:
8063:
8020:
7960:
7928:
7794:
7738:
7639:
7590:
7563:
7555:
7502:
7436:
7409:
7252:
7228:
7149:
7098:
6987:
6850:
6651:
6408:
6244:
4745:
4740:
4735:
4256:
4229:
3942:
3925:
3341:
3316:
2730:"Increasingly irritable and close to tears: TRPA1 in inflammatory pain"
2453:
1720:
1658:
1579:
1480:
1395:
have been reported as TRPA1 agonists, most of the known activators are
1392:
1139:
913:
868:
757:
detection of mechanical stimulus involved in sensory perception of pain
7848:
7706:
7277:
3787:
2256:
2061:
82:
8331:
8307:
8265:
8165:
8093:
7932:
7914:
7772:
7733:
7728:
7506:
7492:
7237:
7153:
7048:
7039:
7029:
7008:
6971:
6942:
6937:
6876:
6868:
6854:
6831:
6328:
6323:
6057:
6052:
5998:
5993:
5809:
5797:
5787:
5782:
5770:
5765:
5760:
5647:
5642:
5637:
5529:
5465:
5460:
5455:
5450:
5445:
5440:
5435:
5370:
5365:
5355:
5350:
5345:
5296:
5291:
5281:
5276:
5153:
5148:
5143:
5138:
5044:
5039:
5034:
5024:
5019:
5009:
5004:
4934:
4929:
4924:
4919:
4822:
4817:
4812:
4807:
4795:
4790:
4785:
4780:
4689:
4656:
4651:
4646:
4641:
3234:
2392:
1750:
1682:
1491:
1464:
1432:
1424:
1388:
1235:
1079:
823:
692:
detection of chemical stimulus involved in sensory perception of pain
6785:
2444:
2096:"Human surrogate models of histaminergic and non-histaminergic itch"
2989:"Structure of the TRPA1 ion channel suggests regulatory mechanisms"
2525:"TRPA1: the central molecule for chemical sensing in pain pathway?"
8335:
8071:
8067:
8024:
7938:
7707:
7574:
7551:
7191:
7068:
6951:
6882:
6562:
6493:
6488:
6483:
6400:
6387:
6382:
6377:
6372:
6367:
6362:
6313:
6306:
6301:
6296:
6291:
6286:
6281:
6276:
6271:
6259:
6254:
6249:
6239:
6234:
6229:
6224:
6139:
6083:
6040:
6035:
6030:
6025:
6020:
6015:
6010:
5988:
5983:
5978:
5973:
5968:
5963:
5958:
5939:
5934:
5929:
5924:
5912:
5829:
5824:
5819:
5804:
5742:
5737:
5732:
5723:
5718:
5704:
5699:
5690:
5685:
5680:
5671:
5666:
5657:
5652:
5619:
5614:
5609:
5604:
5595:
5586:
5581:
5576:
5567:
5562:
5557:
5552:
5543:
5538:
5524:
5519:
5514:
5509:
5504:
5499:
5494:
5430:
5425:
5420:
5415:
5410:
5405:
5400:
5395:
5360:
5330:
5325:
5320:
5315:
5286:
5235:
5230:
5225:
5220:
5210:
5205:
5185:
5170:
5165:
5080:
5075:
5070:
5065:
5049:
5029:
5014:
4975:
4970:
4965:
4960:
4868:
4863:
4586:
4581:
4576:
4195:. Experimental Biology 2016 Meeting. Vol. 30. p. 927.3.
3965:
Pace-Asciak CR (April 2015). "Pathophysiology of the hepoxilins".
2377:"TRPA1 is a major oxidant sensor in murine airway sensory neurons"
1686:
1621:
1617:
1571:
1416:
1223:
1124:
Transient receptor potential cation channel, subfamily A, member 1
786:
782:
8270:
8104:
7849:
7795:
7756:
7447:
7410:
7278:
6642:
6637:
6632:
6622:
6617:
6612:
6602:
6597:
6592:
6587:
6582:
6577:
6572:
6557:
6552:
6547:
6542:
6537:
6532:
6471:
6466:
6461:
6456:
6451:
6357:
6345:
6340:
6335:
6266:
6219:
6183:
6178:
6173:
6168:
5895:
5713:
5271:
4608:
4598:
3044:
Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D (July 2020).
2572:
Nielsen TA, Eriksen MA, Gazerani P, Andersen HH (October 2018).
1690:
1602:) likewise directly activates TRPA1 to amplify pain perception.
1411:. Another example of a nonelectrophilic agent is the anesthetic
1239:
1151:
129:
6744:
6672:
5857:
5103:
4891:
4548:
4501:
2987:
Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D (April 2015).
1238:
and their activation will under normal conditions give rise to
576:
6196:
6094:
5215:
5175:
2094:
Andersen HH, Elberling J, Arendt-Nielsen L (September 2015).
3926:"TRPA1: a transducer and amplifier of pain and inflammation"
3603:"TRP channel activation by reversible covalent modification"
3601:
Hinman A, Chuang HH, Bautista DM, Julius D (December 2006).
8155:
3552:
Cicerale S, Breslin PA, Beauchamp GK, Keast RS (May 2009).
2429:"Nicotine activates the chemosensory cation channel TRPA1"
1447:
is a potent, non-covalent activator of both the human (EC
1562:) directly activate TRPA1 and thereby contribute to the
1427:', 0.3 nM) itself, as well as several other tear gases (
385:
4386:
Ji RR, Xu ZZ, Strichartz G, Serhan CN (November 2011).
4191:
Herz JM, Kesicki E, Tian J, Zhu MX, Thomsen WJ (2016).
4286:
Serhan CN, Chiang N, Dalli J, Levy BD (October 2014).
18:
Transient receptor potential cation channel, member A1
1242:. Indeed, TRPA1 is considered as an attractive pain
550:
6772:
1260:
organs of many snakes, TRPA1 is responsible for the
8385:
7858:
7847:
7827:
7804:
7793:
7765:
7716:
7705:
7583:
7419:
7408:
7333:
7287:
7276:
7216:
6795:
6784:
6685:
6509:
6398:
6194:
6092:
6068:
5870:
5476:
5381:
5246:
5119:
4986:
4945:
4907:
4619:
4564:
4288:"Lipid mediators in the resolution of inflammation"
4001:"Reference SNP (refSNP) Cluster Report: Rs11209716"
2370:
2368:
1288:, cellular co-factors (e.g., inorganic anions like
1036:
1015:
985:
964:
3930:Basic & Clinical Pharmacology & Toxicology
1947:
1945:
1943:
1926:
1924:
1922:
2865:"Molecular basis of infrared detection by snakes"
1574:) receptors to augment the perception of pain. 12
1387:Although several nonelectrophilic agents such as
332:
231:
2920:Geng J, Liang D, Jiang K, Zhang P (2011-12-07).
3658:
3656:
3421:Boonen B, Startek JB, Talavera K (2016-01-01).
2482:
2480:
2422:
2420:
1494:(i.e. arachidonate-12-lipoxygnease) pathway of
762:release of sequestered calcium ion into cytosol
2043:
2041:
2004:Jaquemar D, Schenker T, Trueb B (March 1999).
1952:GRCm38: Ensembl release 89: ENSMUSG00000032769
1358:(cold-triggered acute peripheral neuropathy).
6756:
4513:
4150:Herz JM, Buated W, Thomsen W, Mori Y (2020).
3919:
3917:
3915:
2188:García-Añoveros J, Nagata K (2007). "TRPA1".
8:
3460:Proceedings of the American Thoracic Society
2490:Bioorganic & Medicinal Chemistry Letters
2133:
2131:
2089:
2087:
2190:Transient Receptor Potential (TRP) Channels
1931:GRCh38: Ensembl release 89: ENSG00000104321
1369:Activation of the TRPA1 ion channel by the
7855:
7801:
7713:
7416:
7284:
6792:
6763:
6749:
6741:
6682:
6669:
5867:
5854:
5116:
5100:
4904:
4888:
4561:
4545:
4520:
4506:
4498:
4292:Cold Spring Harbor Perspectives in Biology
1631:More recently, a peptide toxin termed the
1222:" in the body. TRPA1 is co-expressed with
797:
592:
373:
272:
169:
71:
4490:at the U.S. National Library of Medicine
4460:
4435:Serhan CN, Chiang N, Dalli J (May 2015).
4411:
4362:
4352:
4311:
4200:
4167:
4121:
3941:
3895:
3885:
3844:
3834:
3749:
3731:
3636:
3626:
3577:
3528:
3479:
3397:
3340:
3291:
3242:
3193:
3144:
3134:
3077:
3020:
2963:
2945:
2896:
2839:
2829:
2745:
2704:
2694:
2548:
2452:
2400:
2348:
2338:
2111:
2021:
1635:from the Australian black rock scorpion (
625:temperature-gated cation channel activity
1918:
1542:-eicosatrienoic acid) and HxB3 (i.e. 10
1526:) and the hepoxilins (Hx), HxA3 (i.e. 8
712:cell surface receptor signaling pathway
2671:"TRPA1 mediates formalin-induced pain"
1128:transient receptor potential ankyrin 1
31:
6943:CS gas (2-chlorobenzal malononitrile)
4145:
4143:
4141:
4091:
4089:
3223:The Journal of Clinical Investigation
3168:Bessac BF, Jordt SE (December 2008).
2523:Tai C, Zhu S, Zhou N (January 2008).
2381:The Journal of Clinical Investigation
1174:family. TRPA1 contains 14 N-terminal
671:integral component of plasma membrane
337:
298:
293:
236:
195:
190:
7:
4202:10.1096/fasebj.30.1_supplement.927.3
3109:Nagatomo K, Kubo Y (November 2008).
1172:transient receptor potential channel
8515:N-(p-Amylcinnamoyl)anthranilic acid
7631:N-(p-Amylcinnamoyl)anthranilic acid
7371:N-(p-Amylcinnamoyl)anthranilic acid
5886:Calcium-activated chloride channels
3720:The Journal of Biological Chemistry
2280:Toxicology and Applied Pharmacology
2010:The Journal of Biological Chemistry
1423:= 0.05 nM), while dibenzoxazepine (
722:calcium ion transmembrane transport
687:response to organic cyclic compound
4956:Amiloride-sensitive cation channel
4335:Lim JY, Park CK, Hwang SW (2015).
2728:McMahon SB, Wood JN (March 2006).
1701:TRPs and thereby pain perception.
1671:specialized proresolving mediators
1033:
1012:
982:
961:
937:
918:
892:
873:
847:
828:
555:
473:
411:
390:
25:
3454:Bessac BF, Jordt SE (July 2010).
1653:Resolvin D1 (RvD1) and RvD2 (see
1471:, while channel blockers include
1142:that in humans is encoded by the
27:Protein and coding gene in humans
1226:on nociceptive primary afferent
615:calcium-release channel activity
566:
559:
321:
314:
308:
285:
220:
213:
207:
182:
6479:Voltage-dependent anion channel
4572:Inositol trisphosphate receptor
4169:10.1096/fasebj.2020.34.s1.02398
4016:Current Opinion in Pharmacology
2640:10.1097/j.pain.0000000000000979
2590:10.1097/j.pain.0000000000001298
1524:12-Hydroxyeicosatetraenoic acid
1518:-eicosatetraenoic acid (i.e. 12
1262:detection of infrared radiation
1218:) and is thus considered as a "
1190:, farnesyl thiosalicylic acid,
6501:General bacterial porin family
3776:Journal of Medicinal Chemistry
3521:10.1523/JNEUROSCI.1374-10.2011
2783:10.1016/j.brainres.2007.05.047
2541:10.1523/JNEUROSCI.5237-07.2008
2245:Journal of Medicinal Chemistry
1210:) and non-reactive compounds (
656:integral component of membrane
577:More reference expression data
539:More reference expression data
1:
8589:Receptor/signaling modulators
6938:CR gas (dibenzoxazepine; DBO)
4341:BioMed Research International
4052:Pharmacogenetics and Genomics
1146:(and in mice and rats by the
742:response to hydrogen peroxide
707:response to organic substance
306:
205:
4064:10.1097/FPC.0b013e328341041c
3979:10.1016/j.bbalip.2014.09.007
3284:10.1016/j.neuron.2010.04.030
2947:10.1371/journal.pone.0028644
2198:10.1007/978-3-540-34891-7_21
1797:4,5-Epoxyeicosatrienoic acid
8613:Genes on human chromosome 8
8217:Paracetamol (acetaminophen)
7125:Paracetamol (acetaminophen)
6995:Farnesyl thiosalicylic acid
6823:15-Deoxy-Δ-prostaglandin J2
4304:10.1101/cshperspect.a016311
3509:The Journal of Neuroscience
2529:The Journal of Neuroscience
1862:Tetrahydrocannabivarin acid
1558:-eicosatrienoic acid) (see
1496:arachidonic acid metabolism
772:ion transmembrane transport
737:protein homotetramerization
8639:
5920:Chloride Channel Accessory
4529:Membrane transport protein
4453:10.1016/j.smim.2015.03.004
4404:10.1016/j.tins.2011.08.005
4245:Cell Biology International
4114:10.1016/j.cell.2019.07.014
4028:10.1016/j.coph.2011.06.005
3186:10.1152/physiol.00026.2008
2747:10.1016/j.cell.2006.03.006
2502:10.1016/j.bmcl.2011.06.035
2300:10.1016/j.taap.2008.04.005
2147:Acta Dermato-Venereologica
2100:Acta Dermato-Venereologica
1669:. They are members of the
1661:1 are metabolites of the
1614:G protein coupled receptor
1306:reactive oxidative species
732:sensory perception of pain
463:mucosa of transverse colon
8582:
6726:
6681:
6668:
5866:
5853:
5115:
5099:
4915:Epithelial sodium channel
4903:
4887:
4560:
4544:
3472:10.1513/pats.201001-004SM
3070:10.1038/s41586-020-2480-9
1987:"Mouse PubMed Reference:"
1969:"Human PubMed Reference:"
1628:-induce cough in humans.
1560:Hepoxilin#Pain perception
1170:TRPA1 is a member of the
1110:
1105:
1101:
1094:
1078:
1059:
1040:
1019:
1008:
989:
968:
957:
944:
940:
925:
921:
912:
899:
895:
880:
876:
867:
854:
850:
835:
831:
822:
807:
800:
796:
780:
635:identical protein binding
595:
591:
574:
558:
549:
536:
509:glossopharyngeal ganglion
485:
476:
435:mucosa of urinary bladder
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
79:
74:
57:
52:
47:
43:
39:
34:
7202:Umbellularia californica
4832:Cation channels of sperm
4492:Medical Subject Headings
1600:Epoxyeicosatrienoic acid
1407:residues present in the
1274:cryo-electron microscopy
630:calcium channel activity
8172:N-Arachidonoyl dopamine
7954:Andrographis paniculata
4392:Trends in Neurosciences
3836:10.1073/pnas.1110460109
3733:10.1074/jbc.M110.143958
3628:10.1073/pnas.0609598103
3136:10.1073/pnas.0809769105
2696:10.1073/pnas.0705924104
2050:Pharmacological Reviews
2023:10.1074/jbc.274.11.7325
1822:N-Arachidonoyl dopamine
1609:, operates through its
1072:Chr 1: 14.94 – 14.99 Mb
1065:Chr 8: 72.02 – 72.08 Mb
767:transmembrane transport
439:mucosa of sigmoid colon
8593:Ion channel modulators
8322:Tetrahydrocannabivarin
7817:Tripterygium wilfordii
7183:Tetrahydrocannabiorcol
4441:Seminars in Immunology
2831:10.1186/1744-8069-3-39
1857:Tetrahydrocannabivarin
1812:2-Arachidonoylglycerol
1792:-eicosatetraenoic acid
1546:-hydroxy-11,12-oxido-5
1530:-hydroxy-11,12-oxido-5
1256:In the heat-sensitive
489:lumbar spinal ganglion
8150:Lysophosphatidic acid
4908:Constitutively active
3570:10.1093/chemse/bjp006
3370:Nature Communications
3321:Nature Communications
2159:10.2340/00015555-2103
2113:10.2340/00015555-2146
1827:Palmitoylethanolamide
1633:wasabi receptor toxin
1317:Clinical significance
1292:), and lipids (e.g.,
752:calcium ion transport
8530:Pregnenolone sulfate
8351:Euphorbia resinifera
8293:Euphorbia resinifera
8222:Phenylacetylrinvanil
8182:N-Oleoylethanolamide
8130:Homodihydrocapsaicin
7518:Pregnenolone sulfate
7381:Pregnenolone sulfate
7188:Thiopropanal S-oxide
7173:Tetrahydrocannabinol
6861:Allyl isothiocyanate
4488:TRPA1+protein,+human
4108:(6): 1362–1374.e16.
3887:10.1096/fj.12-217414
3431:10.1007/7355_2015_98
2340:10.1096/fj.08-117812
1726:Allyl isothiocyanate
1667:docosahexaenoic acid
1461:allyl isothiocyanate
1451:= 23 nM) and rat (EC
1341:transmembrane domain
1184:allyl isothiocyanate
697:response to stimulus
620:ion channel activity
300:Chromosome 1 (mouse)
198:Chromosome 8 (human)
75:List of PDB id codes
48:Available structures
8435:Cannabigerolic acid
8197:Nordihydrocapsaicin
8158:(acidic conditions)
6675:By gating mechanism
4354:10.1155/2015/830930
3827:2012PNAS..109.6721G
3726:(45): 34781–34792.
3685:10.1038/nature05544
3677:2007Natur.445..541M
3619:2006PNAS..10319564H
3390:10.1038/ncomms12840
3382:2016NatCo...712840M
3333:2011NatCo...2..551A
3127:2008PNAS..10517373N
3062:2020Natur.585..141Z
3013:10.1038/nature14367
3005:2015Natur.520..511P
2938:2011PLoSO...628644G
2889:10.1038/nature08943
2881:2010Natur.464.1006G
2687:2007PNAS..10413525M
2433:Nature Neuroscience
2292:2008ToxAP.231..150B
1847:Cannabigerolic acid
1136:The Wasabi Receptor
651:stereocilium bundle
451:epithelium of colon
8398:Vernonia tweediana
7977:African blue basil
7949:Bisandrographolide
7535:Steviol glycosides
7488:Hydroxycitronellal
7234:Dehydroligustilide
7054:Angelica acutiloba
6968:Dehydroligustilide
6202:TRP cation channel
6100:CNG cation channel
5383:Tandem pore domain
4594:Ryanodine receptor
4257:10.1002/cbin.10345
4230:10.1039/C6MD00387G
3943:10.1111/bcpt.12138
3342:10.1038/ncomms1559
2824:: 1744-8069–3-39.
1832:Cannabidiolic acid
1663:omega 3 fatty acid
1638:Urodacus manicatus
1311:receptor-operation
902:ENSMUSG00000032769
680:Biological process
644:Cellular component
603:Molecular function
8618:Membrane proteins
8600:
8599:
8578:
8577:
8510:Meclofenamic acid
8316:melegueta peppers
8187:Nonivamide (PAVA)
7923:melegueta peppers
7843:
7842:
7789:
7788:
7701:
7700:
7621:Meclofenamic acid
7544:Stevia rebaudiana
7404:
7403:
7366:Meclofenamic acid
7272:
7271:
7162:melegueta peppers
7135:Phenacyl chloride
7090:N-Methylmaleimide
7080:Methyl salicylate
7025:Hydrogen peroxide
6978:Diallyl disulfide
6840:melegueta peppers
6738:
6737:
6722:
6721:
6718:
6717:
6710:Stretch-activated
6687:Ion channel class
6664:
6663:
6660:
6659:
5849:
5848:
5845:
5844:
5121:Calcium-activated
5109:Potassium channel
5095:
5094:
5091:
5090:
4883:
4882:
4879:
4878:
4224:(11): 2145–2158.
4156:The FASEB Journal
3788:10.1021/jm100477n
3440:978-3-319-48925-4
3056:(7823): 141–145.
2875:(7291): 1006–11.
2584:(10): 1989–2001.
2257:10.1021/jm100062h
2207:978-3-540-34889-4
2062:10.1124/pr.57.4.6
1611:prostaglandin EP3
1328:missense mutation
1298:electrophysiology
1282:second messengers
1248:Freund's adjuvant
1196:hydrogen peroxide
1121:
1120:
1117:
1116:
1090:
1089:
1055:
1054:
1030:
1029:
1004:
1003:
979:
978:
953:
952:
934:
933:
908:
907:
889:
888:
863:
862:
844:
843:
792:
791:
587:
586:
583:
582:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
162:TRPA1 - orthologs
94:
93:
90:
89:
58:Ortholog search:
16:(Redirected from
8630:
8445:Cannabigerovarin
8177:N-Oleoyldopamine
8083:Euodia ruticarpa
8049:Dihydrocapsaicin
7856:
7852:
7802:
7798:
7714:
7710:
7458:Cooling Agent 10
7417:
7413:
7285:
7281:
6803:4-Hydroxynonenal
6793:
6789:
6774:
6765:
6758:
6751:
6742:
6683:
6670:
5878:Chloride channel
5868:
5855:
5248:Inward-rectifier
5117:
5101:
4905:
4889:
4859:Two-pore channel
4562:
4546:
4522:
4515:
4508:
4499:
4475:
4474:
4464:
4432:
4426:
4425:
4415:
4383:
4377:
4376:
4366:
4356:
4332:
4326:
4325:
4315:
4283:
4277:
4276:
4240:
4234:
4233:
4213:
4207:
4206:
4204:
4188:
4182:
4181:
4171:
4147:
4136:
4135:
4125:
4093:
4084:
4083:
4046:
4040:
4039:
4011:
4005:
4004:
3997:
3991:
3990:
3962:
3956:
3955:
3945:
3921:
3910:
3909:
3899:
3889:
3865:
3859:
3858:
3848:
3838:
3806:
3800:
3799:
3770:
3764:
3763:
3753:
3735:
3711:
3705:
3704:
3660:
3651:
3650:
3640:
3630:
3598:
3592:
3591:
3581:
3549:
3543:
3542:
3532:
3500:
3494:
3493:
3483:
3451:
3445:
3444:
3418:
3412:
3411:
3401:
3361:
3355:
3354:
3344:
3312:
3306:
3305:
3295:
3263:
3257:
3256:
3246:
3235:10.1172/JCI34886
3214:
3208:
3207:
3197:
3165:
3159:
3158:
3148:
3138:
3106:
3100:
3099:
3081:
3041:
3035:
3034:
3024:
2984:
2978:
2977:
2967:
2949:
2917:
2911:
2910:
2900:
2860:
2854:
2853:
2843:
2833:
2809:
2803:
2802:
2766:
2760:
2759:
2749:
2725:
2719:
2718:
2708:
2698:
2681:(33): 13525–30.
2666:
2660:
2659:
2634:(9): 1723–1732.
2625:
2616:
2610:
2609:
2569:
2563:
2562:
2552:
2520:
2514:
2513:
2484:
2475:
2474:
2456:
2424:
2415:
2414:
2404:
2393:10.1172/JCI34192
2372:
2363:
2362:
2352:
2342:
2318:
2312:
2311:
2275:
2269:
2268:
2251:(14): 5085–107.
2240:
2234:
2233:
2226:
2220:
2219:
2185:
2179:
2178:
2144:
2135:
2126:
2125:
2115:
2091:
2082:
2081:
2045:
2036:
2035:
2025:
2001:
1995:
1994:
1983:
1977:
1976:
1965:
1959:
1949:
1938:
1928:
1868:Gating Modifiers
1852:Cannabigerovarin
1645:TRPA1 inhibition
1607:Prostaglandin E2
1200:4-hydroxynonenal
1126:, also known as
1103:
1102:
1074:
1067:
1050:
1034:
1025:
1013:
1009:RefSeq (protein)
999:
983:
974:
962:
938:
919:
893:
874:
848:
829:
798:
727:response to cold
717:response to pain
610:channel activity
593:
579:
570:
563:
556:
541:
493:secondary oocyte
481:
479:Top expressed in
474:
431:secondary oocyte
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
72:
66:
45:
44:
32:
21:
8638:
8637:
8633:
8632:
8631:
8629:
8628:
8627:
8603:
8602:
8601:
8596:
8574:
8565:Tolfenamic acid
8485:Flufenamic acid
8381:
8288:Resiniferatoxin
8281:Ruta graveolens
8044:Diacyl glycerol
7839:
7823:
7785:
7781:
7761:
7747:
7697:
7683:Tolfenamic acid
7676:Ruta graveolens
7616:Flufenamic acid
7579:
7528:Ruta graveolens
7439:(intracellular)
7400:
7396:Tolfenamic acid
7351:Flufenamic acid
7329:
7305:Diacyl glycerol
7268:
7212:
6898:Cannabichromene
6808:4-Oxo-2-nonenal
6780:
6769:
6739:
6734:
6714:
6677:
6656:
6505:
6404:
6394:
6190:
6088:
6064:
5862:
5841:
5755:
5632:
5489:
5472:
5377:
5341:
5311:
5267:
5259:
5242:
5196:
5111:
5087:
5060:
4999:
4982:
4941:
4899:
4875:
4758:
4730:
4717:
4704:
4684:
4671:
4636:
4615:
4556:
4554:Calcium channel
4540:
4526:
4484:
4479:
4478:
4434:
4433:
4429:
4398:(11): 599–609.
4385:
4384:
4380:
4334:
4333:
4329:
4285:
4284:
4280:
4242:
4241:
4237:
4215:
4214:
4210:
4190:
4189:
4185:
4149:
4148:
4139:
4095:
4094:
4087:
4048:
4047:
4043:
4013:
4012:
4008:
3999:
3998:
3994:
3964:
3963:
3959:
3923:
3922:
3913:
3867:
3866:
3862:
3808:
3807:
3803:
3782:(19): 7011–20.
3772:
3771:
3767:
3713:
3712:
3708:
3671:(7127): 541–5.
3662:
3661:
3654:
3613:(51): 19564–8.
3600:
3599:
3595:
3558:Chemical Senses
3551:
3550:
3546:
3515:(3): 999–1009.
3502:
3501:
3497:
3453:
3452:
3448:
3441:
3423:Taste and Smell
3420:
3419:
3415:
3363:
3362:
3358:
3314:
3313:
3309:
3265:
3264:
3260:
3216:
3215:
3211:
3167:
3166:
3162:
3121:(45): 17373–8.
3108:
3107:
3103:
3043:
3042:
3038:
2999:(7548): 511–7.
2986:
2985:
2981:
2919:
2918:
2914:
2862:
2861:
2857:
2811:
2810:
2806:
2768:
2767:
2763:
2727:
2726:
2722:
2668:
2667:
2663:
2623:
2618:
2617:
2613:
2571:
2570:
2566:
2522:
2521:
2517:
2486:
2485:
2478:
2445:10.1038/nn.2379
2426:
2425:
2418:
2387:(5): 1899–910.
2374:
2373:
2366:
2320:
2319:
2315:
2277:
2276:
2272:
2242:
2241:
2237:
2228:
2227:
2223:
2208:
2187:
2186:
2182:
2142:
2137:
2136:
2129:
2093:
2092:
2085:
2047:
2046:
2039:
2016:(11): 7325–33.
2003:
2002:
1998:
1985:
1984:
1980:
1967:
1966:
1962:
1950:
1941:
1929:
1920:
1915:
1882:
1870:
1741:Cannabichromene
1716:4-Oxo-2-nonenal
1712:
1707:
1705:Ligand examples
1647:
1596:cytochrome P450
1459:is superior to
1454:
1450:
1422:
1364:
1346:Metabolites of
1319:
1270:
1250:and formalin).
1176:ankyrin repeats
1168:
1112:View/Edit Mouse
1107:View/Edit Human
1070:
1063:
1060:Location (UCSC)
1046:
1042:
1021:
995:
991:
970:
883:ENSG00000104321
776:
675:
666:plasma membrane
639:
575:
565:
564:
537:
528:
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
449:
447:mucosa of ileum
445:
441:
437:
433:
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
81:
59:
28:
23:
22:
15:
12:
11:
5:
8636:
8634:
8626:
8625:
8620:
8615:
8605:
8604:
8598:
8597:
8583:
8580:
8579:
8576:
8575:
8573:
8572:
8567:
8562:
8557:
8552:
8547:
8542:
8537:
8532:
8527:
8522:
8517:
8512:
8507:
8502:
8497:
8492:
8487:
8482:
8477:
8472:
8467:
8462:
8452:
8442:
8432:
8422:
8417:
8412:
8407:
8402:
8389:
8387:
8383:
8382:
8380:
8379:
8374:
8364:
8359:
8343:
8329:
8319:
8301:
8285:
8273:
8268:
8263:
8258:
8255:Dorrigo pepper
8248:
8234:
8227:Phorbol esters
8224:
8219:
8214:
8204:
8194:
8184:
8179:
8174:
8169:
8159:
8152:
8147:
8137:
8127:
8117:
8112:
8107:
8102:
8097:
8087:
8075:
8061:
8056:
8046:
8041:
8036:
8014:
8004:
7997:Cannabidivarin
7994:
7984:
7965:camphor laurel
7958:
7946:
7941:
7936:
7926:
7908:
7903:
7898:
7893:
7888:
7883:
7878:
7873:
7868:
7862:
7860:
7853:
7845:
7844:
7841:
7840:
7838:
7837:
7831:
7829:
7825:
7824:
7822:
7821:
7808:
7806:
7799:
7791:
7790:
7787:
7786:
7784:
7783:
7779:
7775:
7769:
7767:
7763:
7762:
7760:
7759:
7754:
7749:
7745:
7741:
7736:
7731:
7726:
7720:
7718:
7711:
7703:
7702:
7699:
7698:
7696:
7695:
7690:
7685:
7680:
7668:
7663:
7658:
7653:
7648:
7643:
7633:
7628:
7626:Mefenamic acid
7623:
7618:
7613:
7608:
7603:
7598:
7593:
7587:
7585:
7581:
7580:
7578:
7577:
7572:
7567:
7548:
7532:
7520:
7515:
7510:
7500:
7495:
7490:
7485:
7480:
7475:
7470:
7460:
7455:
7450:
7445:
7440:
7434:
7429:
7423:
7421:
7414:
7406:
7405:
7402:
7401:
7399:
7398:
7393:
7388:
7383:
7378:
7373:
7368:
7363:
7358:
7353:
7348:
7343:
7337:
7335:
7331:
7330:
7328:
7327:
7322:
7319:St John's wort
7312:
7307:
7302:
7299:St John's wort
7291:
7289:
7282:
7274:
7273:
7270:
7269:
7267:
7266:
7261:
7256:
7246:
7241:
7231:
7226:
7220:
7218:
7214:
7213:
7211:
7210:
7205:
7195:
7185:
7180:
7170:
7165:
7147:
7144:Dorrigo pepper
7137:
7132:
7127:
7122:
7112:
7102:
7092:
7087:
7077:
7072:
7065:Sichuan pepper
7058:
7042:
7037:
7035:Isothiocyanate
7032:
7027:
7022:
7017:
7012:
7002:
6997:
6992:
6980:
6975:
6965:
6955:
6945:
6940:
6935:
6928:Cinnamaldehyde
6925:
6915:
6905:
6895:
6890:
6885:
6880:
6858:
6848:
6843:
6825:
6820:
6815:
6810:
6805:
6799:
6797:
6790:
6782:
6781:
6770:
6768:
6767:
6760:
6753:
6745:
6736:
6735:
6727:
6724:
6723:
6720:
6719:
6716:
6715:
6713:
6712:
6707:
6702:
6697:
6691:
6689:
6679:
6678:
6673:
6666:
6665:
6662:
6661:
6658:
6657:
6655:
6654:
6649:
6648:
6647:
6646:
6645:
6640:
6635:
6627:
6626:
6625:
6620:
6615:
6607:
6606:
6605:
6600:
6595:
6590:
6585:
6580:
6575:
6567:
6566:
6565:
6560:
6555:
6550:
6545:
6540:
6535:
6521:
6519:
6507:
6506:
6504:
6503:
6498:
6497:
6496:
6491:
6486:
6476:
6475:
6474:
6469:
6464:
6459:
6454:
6449:
6444:
6439:
6434:
6429:
6418:
6416:
6402:
6396:
6395:
6393:
6392:
6391:
6390:
6385:
6380:
6375:
6370:
6365:
6355:
6354:
6353:
6348:
6338:
6333:
6332:
6331:
6326:
6321:
6311:
6310:
6309:
6304:
6299:
6294:
6289:
6284:
6279:
6274:
6264:
6263:
6262:
6257:
6252:
6247:
6242:
6237:
6232:
6227:
6217:
6206:
6204:
6192:
6191:
6189:
6188:
6187:
6186:
6181:
6176:
6171:
6166:
6154:
6153:
6152:
6147:
6142:
6132:
6131:
6130:
6125:
6120:
6115:
6104:
6102:
6090:
6089:
6087:
6086:
6080:
6078:
6076:Proton channel
6066:
6065:
6063:
6062:
6061:
6060:
6055:
6045:
6044:
6043:
6038:
6033:
6028:
6023:
6018:
6013:
6003:
6002:
6001:
5996:
5991:
5986:
5981:
5976:
5971:
5966:
5961:
5951:
5946:
5945:
5944:
5943:
5942:
5937:
5932:
5927:
5917:
5916:
5915:
5910:
5900:
5899:
5898:
5882:
5880:
5864:
5863:
5858:
5851:
5850:
5847:
5846:
5843:
5842:
5840:
5839:
5834:
5833:
5832:
5827:
5822:
5812:
5807:
5802:
5801:
5800:
5795:
5790:
5785:
5775:
5774:
5773:
5768:
5763:
5753:
5748:
5747:
5746:
5745:
5740:
5735:
5728:
5727:
5726:
5721:
5716:
5709:
5708:
5707:
5702:
5695:
5694:
5693:
5688:
5683:
5676:
5675:
5674:
5669:
5662:
5661:
5660:
5655:
5650:
5645:
5640:
5630:
5625:
5624:
5623:
5622:
5617:
5612:
5607:
5600:
5599:
5598:
5591:
5590:
5589:
5584:
5579:
5572:
5571:
5570:
5565:
5560:
5555:
5548:
5547:
5546:
5541:
5534:
5533:
5532:
5527:
5522:
5517:
5512:
5507:
5502:
5497:
5487:
5482:
5480:
5474:
5473:
5471:
5470:
5469:
5468:
5463:
5458:
5453:
5448:
5443:
5438:
5433:
5428:
5423:
5418:
5413:
5408:
5403:
5398:
5387:
5385:
5379:
5378:
5376:
5375:
5374:
5373:
5368:
5363:
5358:
5353:
5348:
5339:
5335:
5334:
5333:
5328:
5323:
5318:
5309:
5301:
5300:
5299:
5294:
5289:
5284:
5279:
5274:
5265:
5261:
5257:
5252:
5250:
5244:
5243:
5241:
5240:
5239:
5238:
5233:
5228:
5223:
5218:
5213:
5208:
5203:
5194:
5190:
5189:
5188:
5180:
5179:
5178:
5173:
5168:
5158:
5157:
5156:
5151:
5146:
5141:
5136:
5125:
5123:
5113:
5112:
5104:
5097:
5096:
5093:
5092:
5089:
5088:
5086:
5085:
5084:
5083:
5078:
5073:
5068:
5058:
5054:
5053:
5052:
5047:
5042:
5037:
5032:
5027:
5022:
5017:
5012:
5007:
4997:
4992:
4990:
4984:
4983:
4981:
4980:
4979:
4978:
4973:
4968:
4963:
4952:
4950:
4943:
4942:
4940:
4939:
4938:
4937:
4932:
4927:
4922:
4911:
4909:
4901:
4900:
4897:Sodium channel
4892:
4885:
4884:
4881:
4880:
4877:
4876:
4874:
4873:
4872:
4871:
4866:
4856:
4855:
4854:
4849:
4844:
4839:
4828:
4827:
4826:
4825:
4820:
4815:
4810:
4800:
4799:
4798:
4793:
4788:
4783:
4773:
4772:
4771:
4766:
4756:
4751:
4750:
4749:
4748:
4743:
4738:
4728:
4720:
4715:
4707:
4702:
4694:
4693:
4692:
4682:
4674:
4669:
4661:
4660:
4659:
4654:
4649:
4644:
4634:
4625:
4623:
4617:
4616:
4614:
4613:
4612:
4611:
4606:
4601:
4591:
4590:
4589:
4584:
4579:
4568:
4566:
4558:
4557:
4549:
4542:
4541:
4527:
4525:
4524:
4517:
4510:
4502:
4496:
4495:
4483:
4482:External links
4480:
4477:
4476:
4427:
4378:
4327:
4298:(2): a016311.
4278:
4235:
4208:
4183:
4137:
4085:
4041:
4006:
3992:
3957:
3911:
3880:(5): 1939–49.
3860:
3821:(17): 6721–6.
3801:
3765:
3706:
3652:
3593:
3544:
3495:
3446:
3439:
3413:
3356:
3307:
3258:
3229:(7): 2574–82.
3209:
3160:
3101:
3036:
2979:
2932:(12): e28644.
2912:
2855:
2818:Molecular Pain
2804:
2771:Brain Research
2761:
2720:
2661:
2611:
2564:
2535:(5): 1019–21.
2515:
2496:(16): 4857–9.
2476:
2439:(10): 1293–9.
2416:
2364:
2333:(4): 1102–14.
2313:
2270:
2235:
2221:
2206:
2180:
2153:(7): 798–803.
2127:
2083:
2037:
1996:
1978:
1960:
1939:
1917:
1916:
1914:
1911:
1910:
1909:
1906:
1903:
1900:
1897:
1894:
1889:
1886:
1881:
1878:
1877:
1876:
1869:
1866:
1865:
1864:
1859:
1854:
1849:
1844:
1839:
1837:Cannabidivarin
1834:
1829:
1824:
1819:
1814:
1809:
1804:
1802:Cinnamaldehyde
1799:
1794:
1776:-Hydroperoxy-5
1769:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1723:
1718:
1711:
1708:
1706:
1703:
1695:NMDA receptors
1646:
1643:
1502:-hydroperoxy-5
1490:formed in the
1452:
1448:
1420:
1363:
1362:Ligand binding
1360:
1339:in the fourth
1318:
1315:
1290:polyphosphates
1269:
1266:
1188:cinnamaldehyde
1167:
1164:
1119:
1118:
1115:
1114:
1109:
1099:
1098:
1092:
1091:
1088:
1087:
1085:
1083:
1076:
1075:
1068:
1061:
1057:
1056:
1053:
1052:
1038:
1037:
1031:
1028:
1027:
1017:
1016:
1010:
1006:
1005:
1002:
1001:
987:
986:
980:
977:
976:
966:
965:
959:
955:
954:
951:
950:
942:
941:
935:
932:
931:
923:
922:
916:
910:
909:
906:
905:
897:
896:
890:
887:
886:
878:
877:
871:
865:
864:
861:
860:
852:
851:
845:
842:
841:
833:
832:
826:
820:
819:
814:
809:
805:
804:
794:
793:
790:
789:
778:
777:
775:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
683:
681:
677:
676:
674:
673:
668:
663:
658:
653:
647:
645:
641:
640:
638:
637:
632:
627:
622:
617:
612:
606:
604:
600:
599:
589:
588:
585:
584:
581:
580:
572:
571:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
510:
506:
502:
498:
497:primary oocyte
494:
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
455:jejunal mucosa
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
77:
76:
68:
67:
56:
50:
49:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
8635:
8624:
8621:
8619:
8616:
8614:
8611:
8610:
8608:
8595:
8594:
8590:
8587:
8581:
8571:
8568:
8566:
8563:
8561:
8558:
8556:
8553:
8551:
8548:
8546:
8545:Ruthenium red
8543:
8541:
8538:
8536:
8533:
8531:
8528:
8526:
8525:Niflumic acid
8523:
8521:
8518:
8516:
8513:
8511:
8508:
8506:
8503:
8501:
8498:
8496:
8493:
8491:
8488:
8486:
8483:
8481:
8478:
8476:
8473:
8471:
8468:
8466:
8463:
8460:
8456:
8453:
8450:
8446:
8443:
8440:
8436:
8433:
8430:
8426:
8423:
8421:
8418:
8416:
8413:
8411:
8408:
8406:
8403:
8400:
8399:
8394:
8393:α-Spinasterol
8391:
8390:
8388:
8384:
8378:
8375:
8372:
8368:
8365:
8363:
8360:
8357:
8356:
8352:
8347:
8344:
8341:
8337:
8333:
8330:
8327:
8323:
8320:
8317:
8313:
8309:
8305:
8302:
8299:
8298:
8294:
8289:
8286:
8283:
8282:
8277:
8274:
8272:
8269:
8267:
8264:
8262:
8259:
8256:
8252:
8249:
8246:
8242:
8238:
8235:
8232:
8228:
8225:
8223:
8220:
8218:
8215:
8212:
8208:
8205:
8202:
8198:
8195:
8192:
8188:
8185:
8183:
8180:
8178:
8175:
8173:
8170:
8167:
8163:
8160:
8157:
8153:
8151:
8148:
8145:
8141:
8138:
8135:
8131:
8128:
8125:
8121:
8120:Homocapsaicin
8118:
8116:
8113:
8111:
8108:
8106:
8103:
8101:
8098:
8095:
8091:
8088:
8085:
8084:
8079:
8076:
8073:
8069:
8065:
8062:
8060:
8057:
8054:
8050:
8047:
8045:
8042:
8040:
8037:
8034:
8033:wild bergamot
8030:
8026:
8022:
8018:
8015:
8012:
8008:
8005:
8002:
7998:
7995:
7992:
7988:
7985:
7982:
7981:camphor basil
7978:
7974:
7970:
7966:
7962:
7959:
7956:
7955:
7950:
7947:
7945:
7942:
7940:
7937:
7934:
7930:
7927:
7924:
7920:
7916:
7912:
7909:
7907:
7904:
7902:
7899:
7897:
7894:
7892:
7889:
7887:
7884:
7882:
7879:
7877:
7874:
7872:
7869:
7867:
7864:
7863:
7861:
7857:
7854:
7851:
7846:
7836:
7835:Ruthenium red
7833:
7832:
7830:
7826:
7819:
7818:
7813:
7810:
7809:
7807:
7803:
7800:
7797:
7792:
7782:
7776:
7774:
7771:
7770:
7768:
7764:
7758:
7755:
7753:
7750:
7748:
7742:
7740:
7737:
7735:
7732:
7730:
7727:
7725:
7722:
7721:
7719:
7715:
7712:
7709:
7704:
7694:
7691:
7689:
7686:
7684:
7681:
7678:
7677:
7672:
7669:
7667:
7666:Ruthenium red
7664:
7662:
7659:
7657:
7654:
7652:
7649:
7647:
7646:Niflumic acid
7644:
7641:
7637:
7634:
7632:
7629:
7627:
7624:
7622:
7619:
7617:
7614:
7612:
7609:
7607:
7604:
7602:
7599:
7597:
7594:
7592:
7589:
7588:
7586:
7582:
7576:
7573:
7571:
7568:
7566:; indirectly)
7565:
7561:
7557:
7553:
7549:
7546:
7545:
7540:
7536:
7533:
7530:
7529:
7524:
7521:
7519:
7516:
7514:
7511:
7508:
7504:
7501:
7499:
7496:
7494:
7491:
7489:
7486:
7484:
7481:
7479:
7476:
7474:
7473:Frescolat MGA
7471:
7468:
7464:
7461:
7459:
7456:
7454:
7451:
7449:
7446:
7444:
7441:
7438:
7435:
7433:
7430:
7428:
7425:
7424:
7422:
7418:
7415:
7412:
7407:
7397:
7394:
7392:
7389:
7387:
7384:
7382:
7379:
7377:
7376:Niflumic acid
7374:
7372:
7369:
7367:
7364:
7362:
7359:
7357:
7354:
7352:
7349:
7347:
7344:
7342:
7339:
7338:
7336:
7332:
7326:
7323:
7320:
7316:
7313:
7311:
7308:
7306:
7303:
7300:
7296:
7293:
7292:
7290:
7286:
7283:
7280:
7275:
7265:
7264:Ruthenium red
7262:
7260:
7257:
7254:
7250:
7247:
7245:
7242:
7239:
7235:
7232:
7230:
7227:
7225:
7222:
7221:
7219:
7215:
7209:
7206:
7203:
7199:
7196:
7193:
7189:
7186:
7184:
7181:
7178:
7174:
7171:
7169:
7166:
7163:
7159:
7155:
7151:
7148:
7145:
7141:
7138:
7136:
7133:
7131:
7128:
7126:
7123:
7120:
7116:
7113:
7110:
7106:
7103:
7100:
7096:
7093:
7091:
7088:
7085:
7081:
7078:
7076:
7075:Methylglyoxal
7073:
7070:
7066:
7062:
7059:
7056:
7055:
7050:
7046:
7043:
7041:
7038:
7036:
7033:
7031:
7028:
7026:
7023:
7021:
7018:
7016:
7013:
7010:
7006:
7003:
7001:
6998:
6996:
6993:
6990:
6989:
6984:
6981:
6979:
6976:
6973:
6969:
6966:
6963:
6959:
6956:
6953:
6949:
6948:Cuminaldehyde
6946:
6944:
6941:
6939:
6936:
6933:
6929:
6926:
6923:
6919:
6916:
6913:
6909:
6906:
6903:
6899:
6896:
6894:
6891:
6889:
6886:
6884:
6881:
6878:
6874:
6870:
6866:
6862:
6859:
6856:
6852:
6849:
6847:
6844:
6841:
6837:
6833:
6829:
6826:
6824:
6821:
6819:
6816:
6814:
6811:
6809:
6806:
6804:
6801:
6800:
6798:
6794:
6791:
6788:
6783:
6779:
6776:
6766:
6761:
6759:
6754:
6752:
6747:
6746:
6743:
6733:
6732:
6725:
6711:
6708:
6706:
6705:Voltage-gated
6703:
6701:
6698:
6696:
6693:
6692:
6690:
6688:
6684:
6680:
6676:
6671:
6667:
6653:
6650:
6644:
6641:
6639:
6636:
6634:
6631:
6630:
6628:
6624:
6621:
6619:
6616:
6614:
6611:
6610:
6608:
6604:
6601:
6599:
6596:
6594:
6591:
6589:
6586:
6584:
6581:
6579:
6576:
6574:
6571:
6570:
6568:
6564:
6561:
6559:
6556:
6554:
6551:
6549:
6546:
6544:
6541:
6539:
6536:
6534:
6531:
6530:
6528:
6527:
6526:
6523:
6522:
6520:
6518:
6515:
6513:
6508:
6502:
6499:
6495:
6492:
6490:
6487:
6485:
6482:
6481:
6480:
6477:
6473:
6470:
6468:
6465:
6463:
6460:
6458:
6455:
6453:
6450:
6448:
6445:
6443:
6440:
6438:
6435:
6433:
6430:
6428:
6425:
6424:
6423:
6420:
6419:
6417:
6415:
6412:
6410:
6406:
6397:
6389:
6386:
6384:
6381:
6379:
6376:
6374:
6371:
6369:
6366:
6364:
6361:
6360:
6359:
6356:
6352:
6349:
6347:
6344:
6343:
6342:
6339:
6337:
6334:
6330:
6327:
6325:
6322:
6320:
6317:
6316:
6315:
6312:
6308:
6305:
6303:
6300:
6298:
6295:
6293:
6290:
6288:
6285:
6283:
6280:
6278:
6275:
6273:
6270:
6269:
6268:
6265:
6261:
6258:
6256:
6253:
6251:
6248:
6246:
6243:
6241:
6238:
6236:
6233:
6231:
6228:
6226:
6223:
6222:
6221:
6218:
6215:
6211:
6208:
6207:
6205:
6203:
6200:
6198:
6193:
6185:
6182:
6180:
6177:
6175:
6172:
6170:
6167:
6165:
6162:
6161:
6160:
6159:
6155:
6151:
6148:
6146:
6143:
6141:
6138:
6137:
6136:
6133:
6129:
6126:
6124:
6121:
6119:
6116:
6114:
6111:
6110:
6109:
6106:
6105:
6103:
6101:
6098:
6096:
6091:
6085:
6082:
6081:
6079:
6077:
6074:
6072:
6067:
6059:
6056:
6054:
6051:
6050:
6049:
6046:
6042:
6039:
6037:
6034:
6032:
6029:
6027:
6024:
6022:
6019:
6017:
6014:
6012:
6009:
6008:
6007:
6004:
6000:
5997:
5995:
5992:
5990:
5987:
5985:
5982:
5980:
5977:
5975:
5972:
5970:
5967:
5965:
5962:
5960:
5957:
5956:
5955:
5952:
5950:
5947:
5941:
5938:
5936:
5933:
5931:
5928:
5926:
5923:
5922:
5921:
5918:
5914:
5911:
5909:
5906:
5905:
5904:
5901:
5897:
5894:
5893:
5892:
5889:
5888:
5887:
5884:
5883:
5881:
5879:
5876:
5874:
5869:
5865:
5861:
5860:Miscellaneous
5856:
5852:
5838:
5837:Shaker (gene)
5835:
5831:
5828:
5826:
5823:
5821:
5818:
5817:
5816:
5813:
5811:
5810:minK/ISK-like
5808:
5806:
5803:
5799:
5796:
5794:
5791:
5789:
5786:
5784:
5781:
5780:
5779:
5776:
5772:
5769:
5767:
5764:
5762:
5759:
5758:
5757:
5750:
5749:
5744:
5741:
5739:
5736:
5734:
5731:
5730:
5729:
5725:
5722:
5720:
5717:
5715:
5712:
5711:
5710:
5706:
5703:
5701:
5698:
5697:
5696:
5692:
5689:
5687:
5684:
5682:
5679:
5678:
5677:
5673:
5670:
5668:
5665:
5664:
5663:
5659:
5656:
5654:
5651:
5649:
5646:
5644:
5641:
5639:
5636:
5635:
5634:
5627:
5626:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5602:
5601:
5597:
5594:
5593:
5592:
5588:
5585:
5583:
5580:
5578:
5575:
5574:
5573:
5569:
5566:
5564:
5561:
5559:
5556:
5554:
5551:
5550:
5549:
5545:
5542:
5540:
5537:
5536:
5535:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5511:
5508:
5506:
5503:
5501:
5498:
5496:
5493:
5492:
5491:
5484:
5483:
5481:
5479:
5478:Voltage-gated
5475:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5447:
5444:
5442:
5439:
5437:
5434:
5432:
5429:
5427:
5424:
5422:
5419:
5417:
5414:
5412:
5409:
5407:
5404:
5402:
5399:
5397:
5394:
5393:
5392:
5389:
5388:
5386:
5384:
5380:
5372:
5369:
5367:
5364:
5362:
5359:
5357:
5354:
5352:
5349:
5347:
5344:
5343:
5342:
5336:
5332:
5329:
5327:
5324:
5322:
5319:
5317:
5314:
5313:
5312:
5305:
5302:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5269:
5268:
5262:
5260:
5254:
5253:
5251:
5249:
5245:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5198:
5197:
5191:
5187:
5184:
5183:
5181:
5177:
5174:
5172:
5169:
5167:
5164:
5163:
5162:
5159:
5155:
5152:
5150:
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5131:
5130:
5127:
5126:
5124:
5122:
5118:
5114:
5110:
5107:
5102:
5098:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5063:
5062:
5055:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5002:
5001:
4994:
4993:
4991:
4989:
4988:Voltage-gated
4985:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4958:
4957:
4954:
4953:
4951:
4948:
4944:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4917:
4916:
4913:
4912:
4910:
4906:
4902:
4898:
4895:
4890:
4886:
4870:
4867:
4865:
4862:
4861:
4860:
4857:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4834:
4833:
4830:
4829:
4824:
4821:
4819:
4816:
4814:
4811:
4809:
4806:
4805:
4804:
4801:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4778:
4777:
4774:
4770:
4767:
4765:
4762:
4761:
4760:
4753:
4752:
4747:
4744:
4742:
4739:
4737:
4734:
4733:
4732:
4724:
4721:
4719:
4711:
4708:
4706:
4698:
4695:
4691:
4688:
4687:
4686:
4678:
4675:
4673:
4665:
4662:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4639:
4638:
4630:
4627:
4626:
4624:
4622:
4621:Voltage-gated
4618:
4610:
4607:
4605:
4602:
4600:
4597:
4596:
4595:
4592:
4588:
4585:
4583:
4580:
4578:
4575:
4574:
4573:
4570:
4569:
4567:
4563:
4559:
4555:
4552:
4547:
4543:
4538:
4534:
4530:
4523:
4518:
4516:
4511:
4509:
4504:
4503:
4500:
4493:
4489:
4486:
4485:
4481:
4472:
4468:
4463:
4458:
4454:
4450:
4447:(3): 200–15.
4446:
4442:
4438:
4431:
4428:
4423:
4419:
4414:
4409:
4405:
4401:
4397:
4393:
4389:
4382:
4379:
4374:
4370:
4365:
4360:
4355:
4350:
4346:
4342:
4338:
4331:
4328:
4323:
4319:
4314:
4309:
4305:
4301:
4297:
4293:
4289:
4282:
4279:
4274:
4270:
4266:
4262:
4258:
4254:
4250:
4246:
4239:
4236:
4231:
4227:
4223:
4219:
4212:
4209:
4203:
4198:
4194:
4187:
4184:
4179:
4175:
4170:
4165:
4161:
4157:
4153:
4146:
4144:
4142:
4138:
4133:
4129:
4124:
4119:
4115:
4111:
4107:
4103:
4099:
4092:
4090:
4086:
4081:
4077:
4073:
4069:
4065:
4061:
4057:
4053:
4045:
4042:
4037:
4033:
4029:
4025:
4022:(3): 248–53.
4021:
4017:
4010:
4007:
4002:
3996:
3993:
3988:
3984:
3980:
3976:
3973:(4): 383–96.
3972:
3968:
3961:
3958:
3953:
3949:
3944:
3939:
3935:
3931:
3927:
3920:
3918:
3916:
3912:
3907:
3903:
3898:
3893:
3888:
3883:
3879:
3875:
3874:FASEB Journal
3871:
3864:
3861:
3856:
3852:
3847:
3842:
3837:
3832:
3828:
3824:
3820:
3816:
3812:
3805:
3802:
3797:
3793:
3789:
3785:
3781:
3777:
3769:
3766:
3761:
3757:
3752:
3747:
3743:
3739:
3734:
3729:
3725:
3721:
3717:
3710:
3707:
3702:
3698:
3694:
3690:
3686:
3682:
3678:
3674:
3670:
3666:
3659:
3657:
3653:
3648:
3644:
3639:
3634:
3629:
3624:
3620:
3616:
3612:
3608:
3604:
3597:
3594:
3589:
3585:
3580:
3575:
3571:
3567:
3563:
3559:
3555:
3548:
3545:
3540:
3536:
3531:
3526:
3522:
3518:
3514:
3510:
3506:
3499:
3496:
3491:
3487:
3482:
3477:
3473:
3469:
3466:(4): 269–77.
3465:
3461:
3457:
3450:
3447:
3442:
3436:
3432:
3428:
3424:
3417:
3414:
3409:
3405:
3400:
3395:
3391:
3387:
3383:
3379:
3375:
3371:
3367:
3360:
3357:
3352:
3348:
3343:
3338:
3334:
3330:
3326:
3322:
3318:
3311:
3308:
3303:
3299:
3294:
3289:
3285:
3281:
3278:(5): 671–80.
3277:
3273:
3269:
3262:
3259:
3254:
3250:
3245:
3240:
3236:
3232:
3228:
3224:
3220:
3213:
3210:
3205:
3201:
3196:
3191:
3187:
3183:
3180:(6): 360–70.
3179:
3175:
3171:
3164:
3161:
3156:
3152:
3147:
3142:
3137:
3132:
3128:
3124:
3120:
3116:
3112:
3105:
3102:
3097:
3093:
3089:
3085:
3080:
3075:
3071:
3067:
3063:
3059:
3055:
3051:
3047:
3040:
3037:
3032:
3028:
3023:
3018:
3014:
3010:
3006:
3002:
2998:
2994:
2990:
2983:
2980:
2975:
2971:
2966:
2961:
2957:
2953:
2948:
2943:
2939:
2935:
2931:
2927:
2923:
2916:
2913:
2908:
2904:
2899:
2894:
2890:
2886:
2882:
2878:
2874:
2870:
2866:
2859:
2856:
2851:
2847:
2842:
2837:
2832:
2827:
2823:
2819:
2815:
2808:
2805:
2800:
2796:
2792:
2788:
2784:
2780:
2776:
2772:
2765:
2762:
2757:
2753:
2748:
2743:
2740:(6): 1123–5.
2739:
2735:
2731:
2724:
2721:
2716:
2712:
2707:
2702:
2697:
2692:
2688:
2684:
2680:
2676:
2672:
2665:
2662:
2657:
2653:
2649:
2645:
2641:
2637:
2633:
2629:
2622:
2615:
2612:
2607:
2603:
2599:
2595:
2591:
2587:
2583:
2579:
2575:
2568:
2565:
2560:
2556:
2551:
2546:
2542:
2538:
2534:
2530:
2526:
2519:
2516:
2511:
2507:
2503:
2499:
2495:
2491:
2483:
2481:
2477:
2472:
2468:
2464:
2460:
2455:
2450:
2446:
2442:
2438:
2434:
2430:
2423:
2421:
2417:
2412:
2408:
2403:
2398:
2394:
2390:
2386:
2382:
2378:
2371:
2369:
2365:
2360:
2356:
2351:
2346:
2341:
2336:
2332:
2328:
2327:FASEB Journal
2324:
2317:
2314:
2309:
2305:
2301:
2297:
2293:
2289:
2285:
2281:
2274:
2271:
2266:
2262:
2258:
2254:
2250:
2246:
2239:
2236:
2231:
2225:
2222:
2217:
2213:
2209:
2203:
2199:
2195:
2191:
2184:
2181:
2176:
2172:
2168:
2164:
2160:
2156:
2152:
2148:
2141:
2134:
2132:
2128:
2123:
2119:
2114:
2109:
2105:
2101:
2097:
2090:
2088:
2084:
2079:
2075:
2071:
2067:
2063:
2059:
2056:(4): 427–50.
2055:
2051:
2044:
2042:
2038:
2033:
2029:
2024:
2019:
2015:
2011:
2007:
2000:
1997:
1992:
1988:
1982:
1979:
1974:
1970:
1964:
1961:
1957:
1953:
1948:
1946:
1944:
1940:
1936:
1932:
1927:
1925:
1923:
1919:
1912:
1907:
1904:
1901:
1898:
1895:
1893:
1890:
1887:
1884:
1883:
1879:
1875:
1872:
1871:
1867:
1863:
1860:
1858:
1855:
1853:
1850:
1848:
1845:
1843:
1840:
1838:
1835:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1813:
1810:
1808:
1805:
1803:
1800:
1798:
1795:
1793:
1791:
1787:
1783:
1779:
1775:
1770:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1713:
1709:
1704:
1702:
1700:
1699:down-regulate
1696:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1656:
1651:
1644:
1642:
1640:
1639:
1634:
1629:
1627:
1626:ACE inhibitor
1623:
1619:
1615:
1612:
1608:
1603:
1601:
1598:enzymes (see
1597:
1593:
1589:
1585:
1582:, 5,6-epoxy-8
1581:
1577:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1513:
1509:
1505:
1501:
1497:
1493:
1489:
1484:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1446:
1442:
1441:lipophilicity
1438:
1434:
1430:
1426:
1418:
1414:
1410:
1406:
1402:
1398:
1397:electrophilic
1394:
1390:
1385:
1383:
1379:
1375:
1372:
1367:
1361:
1359:
1355:
1353:
1349:
1344:
1342:
1338:
1333:
1329:
1323:
1316:
1314:
1312:
1307:
1303:
1302:electrophiles
1299:
1295:
1291:
1287:
1283:
1279:
1275:
1267:
1265:
1263:
1259:
1254:
1251:
1249:
1245:
1241:
1237:
1233:
1229:
1225:
1221:
1217:
1213:
1209:
1205:
1201:
1197:
1193:
1189:
1185:
1180:
1177:
1173:
1165:
1163:
1160:
1155:
1153:
1149:
1145:
1141:
1137:
1133:
1129:
1125:
1113:
1108:
1104:
1100:
1097:
1093:
1086:
1084:
1081:
1077:
1073:
1069:
1066:
1062:
1058:
1051:
1049:
1045:
1039:
1035:
1032:
1026:
1024:
1018:
1014:
1011:
1007:
1000:
998:
994:
988:
984:
981:
975:
973:
967:
963:
960:
958:RefSeq (mRNA)
956:
949:
948:
943:
939:
936:
930:
929:
924:
920:
917:
915:
911:
904:
903:
898:
894:
891:
885:
884:
879:
875:
872:
870:
866:
859:
858:
853:
849:
846:
840:
839:
834:
830:
827:
825:
821:
818:
815:
813:
810:
806:
803:
799:
795:
788:
784:
779:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
747:thermoception
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
702:ion transport
700:
698:
695:
693:
690:
688:
685:
684:
682:
679:
678:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
648:
646:
643:
642:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
607:
605:
602:
601:
598:
597:Gene ontology
594:
590:
578:
573:
569:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
30:
19:
8623:Ion channels
8585:
8584:
8425:Cannabigerol
8396:
8349:
8291:
8279:
8241:black pepper
8201:chili pepper
8134:chili pepper
8124:chili pepper
8115:Hepoxilin B3
8110:Hepoxilin A3
8081:
8053:chili pepper
8011:chili pepper
7952:
7815:
7674:
7601:Clotrimazole
7542:
7526:
7478:Frescolat ML
7386:Progesterone
7295:Adhyperforin
7208:WIN 55,212-2
7201:
7052:
7020:Hepoxilin B3
7015:Hepoxilin A3
6986:
6918:Cannabigerol
6728:
6695:Ligand-gated
6686:
6674:
6517:Gap junction
6510:
6399:
6195:
6156:
6134:
6107:
6093:
6069:
6047:
6005:
5953:
5919:
5902:
5890:
5871:
5859:
5814:
5777:
5751:
5628:
5485:
5390:
5337:
5307:
5263:
5192:
5105:
5056:
4995:
4893:
4802:
4775:
4754:
4726:
4713:
4700:
4680:
4667:
4632:
4565:Ligand-gated
4550:
4533:ion channels
4444:
4440:
4430:
4395:
4391:
4381:
4344:
4340:
4330:
4295:
4291:
4281:
4248:
4244:
4238:
4221:
4217:
4211:
4192:
4186:
4159:
4155:
4105:
4101:
4055:
4051:
4044:
4019:
4015:
4009:
3995:
3970:
3966:
3960:
3933:
3929:
3877:
3873:
3863:
3818:
3814:
3804:
3779:
3775:
3768:
3723:
3719:
3709:
3668:
3664:
3610:
3606:
3596:
3564:(4): 333–9.
3561:
3557:
3547:
3512:
3508:
3498:
3463:
3459:
3449:
3422:
3416:
3373:
3369:
3359:
3324:
3320:
3310:
3275:
3271:
3261:
3226:
3222:
3212:
3177:
3173:
3163:
3118:
3114:
3104:
3053:
3049:
3039:
2996:
2992:
2982:
2929:
2925:
2915:
2872:
2868:
2858:
2821:
2817:
2807:
2774:
2770:
2764:
2737:
2733:
2723:
2678:
2674:
2664:
2631:
2627:
2614:
2581:
2577:
2567:
2532:
2528:
2518:
2493:
2489:
2436:
2432:
2384:
2380:
2330:
2326:
2316:
2286:(2): 150–6.
2283:
2279:
2273:
2248:
2244:
2238:
2224:
2189:
2183:
2150:
2146:
2106:(7): 771–7.
2103:
2099:
2053:
2049:
2013:
2009:
1999:
1990:
1981:
1972:
1963:
1842:Cannabigerol
1789:
1785:
1781:
1777:
1773:
1652:
1648:
1636:
1630:
1604:
1591:
1587:
1583:
1575:
1566:and tactile
1564:hyperalgesia
1555:
1551:
1547:
1543:
1539:
1535:
1531:
1527:
1522:-HpETE; see
1519:
1515:
1511:
1507:
1503:
1499:
1485:
1386:
1368:
1365:
1356:
1345:
1324:
1320:
1278:homotetramer
1271:
1255:
1252:
1181:
1169:
1157:TRPA1 is an
1156:
1147:
1143:
1135:
1131:
1127:
1123:
1122:
1048:NP_001335217
1041:
1020:
997:NM_001348288
990:
969:
945:
926:
900:
881:
855:
836:
816:
811:
401:
394:
121:External IDs
80:
29:
8560:Tivanisiran
8465:Capsazepine
8377:Zucapsaicin
8245:long pepper
8211:Pacific yew
8100:GSK1016790A
7987:Cannabidiol
7973:camphorweed
7661:RQ-00203078
7656:PF-05105679
7596:Capsazepine
7361:GSK2293017A
7325:Substance P
7310:GSK1702934A
7259:PF-04745637
7198:Umbellulone
7119:Pacific yew
7105:Oleocanthal
7084:wintergreen
7045:Ligustilide
6908:Cannabidiol
6873:horseradish
6700:Light-gated
5182:IK channel
4251:(1): 3–22.
4218:MedChemComm
4058:(1): 10–7.
3936:(1): 50–5.
2454:10261/16906
1880:Antagonists
1736:Cannabidiol
1616:to trigger
1488:eicosanoids
1409:ion channel
1378:oleocanthal
1348:paracetamol
1232:nociception
1220:chemosensor
1159:ion channel
360:14,989,086
347:14,942,872
339:1|1 A3
259:72,075,584
246:72,019,917
99:Identifiers
8607:Categories
8455:Cannabinol
8355:pooissonii
8346:Tinyatoxin
8297:pooissonii
8261:Probenecid
8251:Polygodial
8207:Paclitaxel
8191:PAVA spray
8078:Evodiamine
8029:pepperwort
7944:Anandamide
7911:α-Sanshool
7859:Activators
7812:Triptolide
7805:Activators
7717:Activators
7693:TRPM4-IN-5
7611:Elismetrep
7539:stevioside
7467:eucalyptus
7463:Eucalyptol
7427:ADP-ribose
7420:Activators
7356:GSK417651A
7315:Hyperforin
7288:Activators
7168:Tear gases
7140:Polygodial
7130:PF-4840154
7115:Paclitaxel
6983:Dicentrine
6893:Bradykinin
6828:α-Sanshool
6796:Activators
6778:modulators
5903:Bestrophin
5161:SK channel
5129:BK channel
4803:γ-subunits
4776:β-subunits
4759:δ-subunits
4347:: 830930.
3327:(2): 551.
3174:Physiology
1958:, May 2017
1937:, May 2017
1913:References
1908:ALGX-2542
1817:Anandamide
1807:PF-4840154
1766:Hepoxilins
1756:Polygodial
1679:astrocytes
1457:PF-4840154
1445:PF-4840154
1435:(0.9 nM),
1403:bond with
1258:loreal pit
1216:PF-4840154
1208:tear gases
405:(ortholog)
142:HomoloGene
8586:See also:
8570:TRPV3-74a
8555:SB-705498
8550:SB-366791
8500:Lanthanum
8495:HC-067047
8415:Asivatrep
8276:Rutamarin
8140:Incensole
8090:Gingerols
8059:Estradiol
8035:, others)
8017:Carvacrol
8007:Capsaicin
7901:13-oxoODE
7891:12S-HpETE
7871:5',6'-EET
7671:Rutamarin
7570:Thio-BCTC
7523:Rutamarin
7453:Coolact P
7244:HC-030031
7109:olive oil
7005:Gingerols
6818:12S-HpETE
6731:disorders
6729:see also
6512:Cytoplasm
6422:Aquaporin
5891:Anoctamin
5714:11.1/hERG
4178:218776153
4162:(S1): 1.
3742:1083-351X
3376:: 12840.
3096:220407248
2956:1932-6203
2777:: 39–46.
1905:ALGX-2561
1902:ALGX-2563
1899:ALGX-2541
1896:ALGX-2513
1885:HC-030031
1768:A3 and B3
1675:microglia
1655:resolvins
1568:allodynia
1477:HC-030031
1431:(30 nM),
1382:olive oil
1376:compound
1371:olive oil
1352:capsaicin
1272:In 2016,
1268:Structure
1044:NP_808449
1023:NP_015628
993:NM_177781
972:NM_007332
802:Orthologs
150:GeneCards
8520:NGD-8243
8505:Mavatrep
8490:GRC-6211
8459:cannabis
8449:cannabis
8439:cannabis
8429:cannabis
8410:AMG-9810
8386:Blockers
8367:Vanillin
8362:Tramadol
8326:cannabis
8304:Shogaols
8237:Piperine
8001:cannabis
7991:cannabis
7969:rosemary
7886:12S-HETE
7881:9-oxoODE
7828:Blockers
7778:PI(4,5)P
7766:Blockers
7744:PI(3,5)P
7651:Ononetin
7636:Nicotine
7584:Blockers
7560:fructose
7552:tastants
7498:Linalool
7483:Geraniol
7443:CIM-0216
7334:Blockers
7249:Nicotine
7224:A-967079
7217:Blockers
7177:cannabis
7150:Shogaols
7095:Nicotine
7061:Linalool
7000:Formalin
6962:turmeric
6958:Curcumin
6932:cinnamon
6922:cannabis
6912:cannabis
6902:cannabis
6888:ASP-7663
6846:Acrolein
6525:Connexin
5805:minK/ISK
4471:25857211
4422:21963090
4373:26339646
4322:25359497
4273:10160642
4265:25052386
4132:31447178
4080:22282464
4072:21052031
4036:21727026
3987:25240838
3952:24102997
3906:23382512
3855:22493235
3796:20806939
3760:20826794
3693:17237762
3647:17164327
3588:19273462
3539:21248124
3490:20601631
3408:27628562
3351:22109525
3302:20547126
3253:18568077
3204:19074743
3155:18988737
3088:32641835
3031:25855297
2974:22163322
2926:PLOS ONE
2907:20228791
2850:18086308
2799:25946719
2791:17588549
2756:16564004
2715:17686976
2656:23263861
2648:28614189
2606:44150443
2598:29847470
2559:18234879
2510:21741838
2463:19749751
2411:18398506
2359:19036859
2308:18501939
2265:20356305
2216:17217068
2175:10418526
2167:25792226
2122:26015312
2078:17936350
2070:16382100
2032:10066796
1954:–
1933:–
1892:A-967079
1888:GRC17536
1761:Propofol
1746:Gingerol
1731:ASP-7663
1710:Agonists
1473:A-967079
1469:ASP-7663
1413:propofol
1405:cysteine
1401:covalent
1374:phenolic
1337:mutation
1332:Colombia
1286:calcium)
1228:C-fibers
1212:nicotine
1204:acrolein
1192:formalin
1166:Function
1138:, is a
1096:Wikidata
781:Sources:
661:membrane
517:epiblast
8540:RN-9893
8535:RN-1734
8405:AMG-517
8371:vanilla
8340:oregano
8312:Sichuan
8290:(RTX) (
8266:Protons
8229:(e.g.,
8162:Menthol
8144:incense
8064:Eugenol
8021:oregano
7961:Camphor
7929:Allicin
7919:Sichuan
7906:20-HETE
7896:13-HODE
7739:ML2-SA1
7640:tobacco
7591:AMG-333
7564:sucrose
7556:glucose
7554:(e.g.,
7537:(e.g.,
7503:Menthol
7437:Calcium
7253:tobacco
7229:AM-0902
7158:Sichuan
7099:tobacco
6988:Lindera
6865:mustard
6851:Allicin
6836:Sichuan
6813:4,5-EET
6775:channel
6652:Innexin
6409:solutes
4462:4515371
4413:3200462
4364:4538417
4313:4315926
4123:6731142
3897:3633813
3846:3340022
3823:Bibcode
3751:2966094
3701:4344572
3673:Bibcode
3638:1748265
3615:Bibcode
3579:4357805
3530:3073417
3481:3136963
3399:5027619
3378:Bibcode
3329:Bibcode
3293:4769261
3244:2430498
3195:2735846
3146:2582301
3123:Bibcode
3079:7483980
3058:Bibcode
3022:4409540
3001:Bibcode
2965:3233596
2934:Bibcode
2898:2855400
2877:Bibcode
2841:2222611
2706:1941642
2683:Bibcode
2550:6671416
2471:1670299
2402:2289796
2350:2660642
2288:Bibcode
1956:Ensembl
1935:Ensembl
1721:Allicin
1659:maresin
1580:epoxide
1481:AM-0902
1425:CR 'gas
1393:menthol
1284:(e.g.,
1140:protein
914:UniProt
869:Ensembl
808:Species
787:QuickGO
521:jejunum
380:pattern
238:8q21.11
138:3522699
106:Aliases
8480:DHEA-S
8332:Thymol
8308:ginger
8231:4α-PDD
8094:ginger
7933:garlic
7915:ginger
7876:9-HODE
7773:ML-SI3
7734:ML-SA1
7729:MK6-83
7550:Sweet
7513:PMD 38
7493:Icilin
7346:DHEA-S
7238:celery
7154:ginger
7049:celery
7040:JT-010
7030:Icilin
7009:ginger
6972:celery
6877:wasabi
6869:radish
6855:garlic
6832:ginger
4949:-gated
4947:Proton
4723:T-type
4710:R-type
4697:Q-type
4677:P-type
4664:N-type
4629:L-type
4494:(MeSH)
4469:
4459:
4420:
4410:
4371:
4361:
4320:
4310:
4271:
4263:
4176:
4130:
4120:
4078:
4070:
4034:
3985:
3950:
3904:
3894:
3853:
3843:
3794:
3758:
3748:
3740:
3699:
3691:
3665:Nature
3645:
3635:
3586:
3576:
3537:
3527:
3488:
3478:
3437:
3406:
3396:
3349:
3300:
3290:
3272:Neuron
3251:
3241:
3202:
3192:
3153:
3143:
3094:
3086:
3076:
3050:Nature
3029:
3019:
2993:Nature
2972:
2962:
2954:
2905:
2895:
2869:Nature
2848:
2838:
2797:
2789:
2754:
2713:
2703:
2654:
2646:
2604:
2596:
2557:
2547:
2508:
2469:
2461:
2409:
2399:
2357:
2347:
2306:
2263:
2214:
2204:
2173:
2165:
2120:
2076:
2068:
2030:
1751:Icilin
1693:, and
1683:CMKLR1
1657:) and
1492:ALOX12
1465:JT-010
1389:thymol
1244:target
1236:humans
1206:, and
1082:search
1080:PubMed
947:Q8BLA8
928:O75762
857:277328
824:Entrez
551:BioGPS
513:embryo
505:embryo
501:zygote
443:rectum
427:oocyte
130:604775
8470:DCDPC
8336:thyme
8072:clove
8068:basil
8025:thyme
7939:AM404
7866:2-APB
7752:SF-22
7724:EVP21
7708:TRPML
7606:DCDPC
7575:WS-12
7341:DCDPC
7192:onion
7069:thyme
6991:spp.)
6952:cumin
6883:AM404
6563:GJA10
6414:Porin
6314:TRPML
6084:HVCN1
5778:KCNIP
5633:α7-12
4537:TC 1A
4269:S2CID
4174:S2CID
4076:S2CID
3697:S2CID
3092:S2CID
2795:S2CID
2652:S2CID
2624:(PDF)
2602:S2CID
2467:S2CID
2171:S2CID
2143:(PDF)
2074:S2CID
1687:GPR32
1622:TRPV1
1618:cough
1572:TRPV1
1417:TRPV1
1224:TRPV1
1148:Trpa1
1144:TRPA1
1134:, or
1132:TRPA1
817:Mouse
812:Human
783:Amigo
525:colon
459:gonad
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
154:TRPA1
113:TRPA1
35:TRPA1
8475:DHEA
8420:BCTC
8314:and
8271:RhTx
8166:mint
8154:Low
8105:Heat
8039:DHEA
7921:and
7850:TRPV
7796:TRPP
7757:SN-2
7688:TPPO
7507:mint
7448:Cold
7432:BCTC
7411:TRPM
7391:Pyr3
7279:TRPC
7160:and
6838:and
6787:TRPA
6643:GJD4
6638:GJD3
6633:GJD2
6623:GJC3
6618:GJC2
6613:GJC1
6603:GJB7
6598:GJB6
6593:GJB5
6588:GJB4
6583:GJB3
6578:GJB2
6573:GJB1
6558:GJA9
6553:GJA8
6548:GJA5
6543:GJA4
6538:GJA3
6533:GJA1
6358:TRPV
6341:TRPP
6336:TRPN
6267:TRPM
6220:TRPC
6210:TRPA
6048:CLNS
6006:CLIC
5954:CLCN
5949:CFTR
5896:ANO1
5815:MiRP
5743:12.3
5738:12.2
5733:12.1
5724:11.3
5719:11.2
5705:10.2
5700:10.1
5490:α1-6
5304:GIRK
4718:α2.3
4705:α2.1
4672:α2.2
4467:PMID
4418:PMID
4369:PMID
4345:2015
4318:PMID
4261:PMID
4128:PMID
4102:Cell
4068:PMID
4032:PMID
3983:PMID
3971:1851
3948:PMID
3902:PMID
3851:PMID
3792:PMID
3756:PMID
3738:ISSN
3689:PMID
3643:PMID
3584:PMID
3535:PMID
3486:PMID
3435:ISBN
3404:PMID
3347:PMID
3298:PMID
3249:PMID
3200:PMID
3151:PMID
3084:PMID
3027:PMID
2970:PMID
2952:ISSN
2903:PMID
2846:PMID
2787:PMID
2775:1160
2752:PMID
2734:Cell
2711:PMID
2644:PMID
2628:Pain
2594:PMID
2578:Pain
2555:PMID
2506:PMID
2459:PMID
2407:PMID
2355:PMID
2304:PMID
2261:PMID
2212:PMID
2202:ISBN
2163:PMID
2118:PMID
2066:PMID
2028:PMID
1874:WaTx
1691:FPR2
1498:, 12
1486:The
1479:and
1467:and
1391:and
1294:PIP2
1240:pain
1152:gene
838:8989
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
146:7189
126:OMIM
83:3J9P
64:RCSB
61:PDBe
7541:) (
6773:TRP
6407:(+
6245:4AP
6158:HCN
5691:9.3
5686:9.2
5681:9.1
5672:8.2
5667:8.1
5658:7.5
5653:7.4
5648:7.3
5643:7.2
5638:7.1
5620:6.4
5615:6.3
5610:6.2
5605:6.1
5596:5.1
5587:4.3
5582:4.2
5577:4.1
5568:3.4
5563:3.3
5558:3.2
5553:3.1
5544:2.2
5539:2.1
5530:1.8
5525:1.7
5520:1.6
5515:1.5
5510:1.4
5505:1.3
5500:1.2
5495:1.1
5391:K2P
5371:7.1
5366:6.2
5361:6.1
5356:5.1
5351:4.2
5346:4.1
5331:3.4
5326:3.3
5321:3.2
5316:3.1
5297:2.6
5292:2.4
5287:2.3
5282:2.2
5277:2.1
5272:1.1
5258:ATP
5236:5.1
5231:4.2
5226:4.1
5221:3.1
5216:2.3
5211:2.2
5206:2.1
5201:1.1
5186:IK1
5176:SK3
5171:SK2
5166:SK1
5045:1.9
5040:1.8
5035:1.7
5030:1.6
5025:1.5
5020:1.4
5015:1.3
5010:1.2
5005:1.1
4894:Na:
4746:3.3
4741:3.2
4736:3.1
4690:2.1
4657:1.4
4652:1.3
4647:1.2
4642:1.1
4551:Ca:
4457:PMC
4449:doi
4408:PMC
4400:doi
4359:PMC
4349:doi
4308:PMC
4300:doi
4253:doi
4226:doi
4197:doi
4164:doi
4118:PMC
4110:doi
4106:178
4060:doi
4024:doi
3975:doi
3938:doi
3934:114
3892:PMC
3882:doi
3841:PMC
3831:doi
3819:109
3784:doi
3746:PMC
3728:doi
3724:285
3681:doi
3669:445
3633:PMC
3623:doi
3611:103
3574:PMC
3566:doi
3525:PMC
3517:doi
3476:PMC
3468:doi
3427:doi
3394:PMC
3386:doi
3337:doi
3288:PMC
3280:doi
3239:PMC
3231:doi
3227:118
3190:PMC
3182:doi
3141:PMC
3131:doi
3119:105
3074:PMC
3066:doi
3054:585
3017:PMC
3009:doi
2997:520
2960:PMC
2942:doi
2893:PMC
2885:doi
2873:464
2836:PMC
2826:doi
2779:doi
2742:doi
2738:124
2701:PMC
2691:doi
2679:104
2636:doi
2632:158
2586:doi
2582:159
2545:PMC
2537:doi
2498:doi
2449:hdl
2441:doi
2397:PMC
2389:doi
2385:118
2345:PMC
2335:doi
2296:doi
2284:231
2253:doi
2194:doi
2155:doi
2108:doi
2058:doi
2018:doi
2014:274
1788:,14
1784:,10
1677:or
1590:,14
1586:,11
1554:,14
1544:R/S
1538:,14
1528:R/S
1514:,14
1510:,10
1234:in
356:End
255:End
158:OMA
134:MGI
54:PDB
8609::
8591:•
8338:,
8310:,
8243:,
8156:pH
8070:,
8031:,
8027:,
8023:,
7979:,
7975:,
7971:,
7967:,
7917:,
7562:,
7558:,
7156:,
7067:,
7051:,
6875:,
6871:,
6867:,
6834:,
6629:D
6609:C
6569:B
6529:A
6411:):
6164:FC
6058:1B
6053:1A
6041:L1
5999:KB
5994:KA
5873:Cl
5466:18
5461:17
5456:16
5451:15
5446:13
5441:12
5436:10
5340:ir
5310:ir
5266:ir
5195:Ca
5154:β4
5149:β3
5144:β2
5139:β1
5134:α1
5106:K:
5057:Na
5050:7A
4996:Na
4823:γ4
4818:γ3
4813:γ2
4808:γ1
4796:β4
4791:β3
4786:β2
4781:β1
4727:Ca
4714:Ca
4701:Ca
4681:Ca
4668:Ca
4633:Ca
4531::
4465:.
4455:.
4445:27
4443:.
4439:.
4416:.
4406:.
4396:34
4394:.
4390:.
4367:.
4357:.
4343:.
4339:.
4316:.
4306:.
4294:.
4290:.
4267:.
4259:.
4249:39
4247:.
4220:.
4172:.
4160:34
4158:.
4154:.
4140:^
4126:.
4116:.
4104:.
4100:.
4088:^
4074:.
4066:.
4056:21
4054:.
4030:.
4020:11
4018:.
3981:.
3969:.
3946:.
3932:.
3928:.
3914:^
3900:.
3890:.
3878:27
3876:.
3872:.
3849:.
3839:.
3829:.
3817:.
3813:.
3790:.
3780:53
3778:.
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