448:
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31:
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The most common side effects in adults and children are infections, nausea (feeling sick), stomatitis (inflammation of the lining of the mouth), vomiting, diarrhoea and abdominal pain (belly ache). Tiredness, febrile neutropenia (low white blood cell counts with fever) and high blood levels of
658:
In one of the studies, involving 570 adults with acute myeloid leukaemia (a blood cancer) or myelodysplastic syndromes (conditions in which large numbers of abnormal blood cells are produced), 64% of patients given treosulfan (with fludarabine) had a successful transplant and were alive and
665:
On 23 February 2004, orphan designation (EU/3/04/186) was granted by the
European Commission to medac Gesellschaft fuer klinische Spezialpräparate mbH, Germany, for treosulfan for the conditioning treatment prior to haematopoietic progenitor cell transplantation.
913:"Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives"
613:. It is used as a 'conditioning' treatment to clear the bone marrow and make room for the transplanted bone marrow cells, which can then produce healthy blood cells. It is used together with another medicine called
737:
624:. In the body, treosulfan is converted into other compounds called epoxides which kill cells, especially cells that develop rapidly such as bone marrow cells, by attaching to their DNA while they are dividing.
172:
2879:
127:
585:
2830:
517:
1040:
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640:
haematopoietic stem cell transplantation (alloHSCT) in adults with malignant and non malignant diseases, and in children older than one month with malignant diseases.
765:
65:
1740:
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662:
In an additional study in 70 children with blood cancers, 99% of children given treosulfan (with fludarabine) were alive 3 months after their transplant.
971:
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713:
617:
in adults and children from one month of age with blood cancers as well as in adults with other severe disorders requiring a bone marrow transplant.
610:
628:
bilirubin (a breakdown product of red blood cells) are also seen in more than 1 in 10 adults, and rash also affects more than 1 in 10 children.
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56:
1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, Threitol 1,4-dimethanesulfonate, Threitol 1,4-bismethanesulfonate;
2864:
2849:
2643:
2576:
2546:
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1414:
1007:
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Treosulfan in combination with fludarabine is indicated as part of conditioning treatment prior to
420:
252:
116:
609:, is a medication given to people before they have a bone marrow transplant from a donor known as
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83:
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1071:
942:
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disease-free after 2 years, compared with 51% of patients given busulfan (with fludarabine).
326:
2668:
2425:
2140:
1774:
1759:
1480:
932:
924:
794:"Treosulfan 5g Powder for Solution for Infusion - Summary of Product Characteristics (SmPC)"
460:
346:
2793:
2766:
2107:
2069:
1860:
1282:
1197:
753:
741:
692:
655:, another medicine used to prepare patients for haematopoietic stem cell transplantation.
569:
InChI=1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1
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60:-Threitol 1,4-bis(methanesulfonate); Threosulphan; Treosulphan; Tresulfan
306:
1500:
1401:
1215:
1076:
272:
30:
766:"Health product highlights 2021: Annexes of products approved in 2021"
1140:
651:
Two main studies showed that treosulfan is at least as effective as
648:
Treosulfan was approved for use in the
European Union in June 2019.
16:
Medication given to people before they have a bone marrow transplant
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989:
This article incorporates text from this source, which is in the
897:
This article incorporates text from this source, which is in the
735:
TRECONDI (Link
Medical Products Pty Ltd T/A Link Pharmaceuticals)
357:
203:
190:
1022:
706:"Updates to the Prescribing Medicines in Pregnancy database"
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94:
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https://www.tga.gov.au/resources/auspar/auspar-trecondi
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911:Romański M, Wachowiak J, Główka FK (October 2018).
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611:allogeneic hematopoietic stem cell transplantation
243:)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate
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2880:Antineoplastic and immunomodulating drug stubs
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1034:
533:101.5 to 105 °C (214.7 to 221.0 °F)
8:
21:
211:In general: ℞ (Prescription only)
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620:It belongs to the family of drugs called
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710:Therapeutic Goods Administration (TGA)
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20:
392:
74:
7:
2778:
2776:
974:from the original on 16 October 2019
139:
1310:ribonucleotide reductase inhibitors
372:
365:
276:
2803:. You can help Knowledge (XXG) by
1476:Ribonucleotide reductase inhibitor
1432:Ribonucleotide reductase inhibitor
882:from the original on 16 March 2023
744:Department of Health and Aged Care
695:Department of Health and Aged Care
14:
1235:Dihydrofolate reductase inhibitor
716:from the original on 3 April 2022
2860:Alkylating antineoplastic agents
2780:
2760:
984:
892:
804:from the original on 20 May 2022
471:
574:Key:YCPOZVAOBBQLRI-WDSKDSINSA-N
1372:Thymidylate synthase inhibitor
1262:Thymidylate synthase inhibitor
824:"Trecondi Product Information"
549:CS(=O)(=O)OC((COS(=O)(=O)C)O)O
483:
477:
465:
1:
1292:Adenosine deaminase inhibitor
1133:Block microtubule disassembly
605:, sold under the brand name
2896:
2775:
455:Chemical and physical data
2711:
2592:Omacetaxine mepesuccinate
2472:Ciltacabtagene autoleucel
2462:Brexucabtagene autoleucel
1012:National Cancer Institute
966:European Medicines Agency
929:10.1007/s40262-018-0647-4
917:Clinical Pharmacokinetics
874:European Medicines Agency
832:European Medicines Agency
582:
557:
537:
223:
28:
2855:IARC Group 1 carcinogens
2644:Talimogene laherparepvec
2577:Nadofaragene firadenovec
2547:Lisocabtagene maraleucel
1496:Topoisomerase inhibitors
1415:DNA polymerase inhibitor
76:International Drug Names
2447:Axicabtagene ciloleucel
1051:chemotherapeutic agents
740:12 October 2022 at the
2629:Sitimagene ceradenovec
2527:Idecabtagene vicleucel
2092:Methyl aminolevulinate
2103:Porphyrin derivatives
1799:Melphalan flufenamide
1446:Hypomethylating agent
1055:antineoplastic agents
970:. 17 September 2018.
2432:Asparagine depleters
2361:Receptor antagonists
2275:+abiraterone acetate
878:. 11 December 2018.
712:. 21 December 2022.
2482:Denileukin diftitox
2382:Retinoid X receptor
2082:Aminolevulinic acid
1904:Triethylenemelamine
1736:Crosslinking of DNA
1467:Deoxyribonucleotide
1406:+gimeracil/oteracil
691:9 June 2023 at the
199:(Prescription only)
175:(Prescription only)
25:
2738:Never to phase III
1540:Etirinotecan pegol
2812:
2811:
2748:
2747:
2707:
2706:
2664:Tigilanol tiglate
2141:Enzyme inhibitors
2064:
2063:
2060:
2059:
1760:Nitrogen mustards
1730:
1729:
1490:
1489:
1192:
1191:
923:(10): 1255–1265.
622:alkylating agents
600:
599:
518:Interactive image
405:CompTox Dashboard
207:
194:
182:
170:
98:
59:
48:Trecondi, Ovastat
2887:
2833:
2826:
2819:
2794:immunomodulatory
2784:
2777:
2765:
2764:
2763:
2756:
2669:Tisagenlecleucel
2426:Arsenic trioxide
2137:
2070:Photosensitizers
1861:Alkyl sulfonates
1775:Cyclophosphamide
1747:
1686:Anthracenediones
1507:
1481:Hydroxycarbamide
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1205:
1083:
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836:. 21 April 2020.
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2865:Mesylate esters
2850:Alkylsulfonates
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2728:Clinical trials
2703:
2409:Other/ungrouped
2404:
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2128:
2108:Porfimer sodium
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2018:
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1908:
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1277:
1213:
1211:antimetabolites
1209:
1208:DNA precursors/
1200:
1198:DNA replication
1188:
1128:
1098:Vinca alkaloids
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869:"Trecondi EPAR"
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774:. 3 August 2022
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35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
2892:
2881:
2878:
2876:
2875:Vicinal diols
2873:
2871:
2868:
2866:
2863:
2861:
2858:
2856:
2853:
2851:
2848:
2847:
2845:
2834:
2829:
2827:
2822:
2820:
2815:
2814:
2808:
2806:
2802:
2799:article is a
2798:
2795:
2791:
2786:
2783:
2779:
2774:
2768:
2758:
2754:
2737:
2735:
2732:
2731:
2729:
2726:
2723:
2720:
2718:
2715:
2714:
2710:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2619:
2616:
2614:
2610:
2609:
2605:
2603:
2602:Tabelecleucel
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2562:Lurbinectedin
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
2460:
2458:
2455:
2453:
2450:
2448:
2445:
2442:
2438:
2434:
2433:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2413:
2411:
2407:
2400:
2396:
2395:
2391:
2388:
2384:
2383:
2379:
2376:
2372:
2371:
2367:
2366:
2364:
2362:
2358:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2327:
2325:
2321:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2294:
2293:
2289:
2286:
2283:
2281:
2278:
2276:
2273:
2270:
2268:
2264:
2263:
2259:
2256:
2252:
2251:
2247:
2244:
2240:
2239:
2235:
2232:
2228:
2227:
2223:
2219:
2216:
2214:
2211:
2209:
2206:
2204:
2201:
2200:
2199:
2198:
2194:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2167:
2166:
2163:
2159:
2156:
2152:
2151:
2147:
2146:
2144:
2142:
2138:
2135:
2131:
2124:
2121:
2119:
2116:
2114:
2111:
2109:
2105:
2104:
2100:
2098:
2095:
2093:
2090:
2088:
2085:
2083:
2080:
2079:
2077:
2075:
2071:
2067:
2052:
2049:
2047:
2044:
2042:
2039:
2037:
2033:
2030:
2029:
2027:
2025:
2024:Intercalation
2021:
2014:
2011:
2009:
2006:
2004:
2000:
1999:
1995:
1993:
1990:
1988:
1985:
1983:
1980:
1977:
1973:
1972:
1968:
1966:
1963:
1962:
1960:
1958:
1954:
1948:
1945:
1943:
1940:
1938:
1935:
1933:
1932:Dicycloplatin
1930:
1928:
1925:
1923:
1920:
1919:
1917:
1915:
1911:
1905:
1902:
1900:
1897:
1895:
1892:
1890:
1887:
1885:
1881:
1880:
1876:
1873:
1871:
1867:
1864:
1862:
1858:
1857:
1854:
1851:
1849:
1846:
1844:
1841:
1838:
1834:
1831:
1829:
1826:
1824:
1821:
1819:
1815:
1814:
1811:
1808:
1806:
1805:Prednimustine
1803:
1800:
1796:
1793:
1791:
1788:
1785:
1782:
1780:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1757:
1756:
1754:
1752:
1748:
1745:
1742:
1737:
1733:
1723:
1720:
1718:
1715:
1713:
1710:
1708:
1705:
1702:
1699:
1697:
1694:
1692:
1688:
1687:
1683:
1680:
1677:
1675:
1672:
1670:
1667:
1665:
1662:
1660:
1657:
1655:
1652:
1649:
1645:
1642:
1640:
1637:
1635:
1631:
1630:
1626:
1625:
1623:
1621:
1620:Intercalation
1617:
1613:
1606:
1603:
1601:
1597:
1596:
1592:
1591:
1589:
1587:
1583:
1576:
1573:
1571:
1568:
1566:
1563:
1561:
1558:
1556:
1553:
1551:
1548:
1546:
1543:
1541:
1538:
1536:
1533:
1531:
1528:
1526:
1522:
1521:
1517:
1516:
1514:
1512:
1508:
1505:
1502:
1497:
1493:
1482:
1478:
1477:
1473:
1472:
1470:
1468:
1464:
1457:
1454:
1452:
1448:
1447:
1443:
1442:
1438:
1434:
1433:
1429:
1428:
1424:
1423:+daunorubicin
1421:
1417:
1416:
1412:
1411:
1407:
1403:
1400:
1398:
1395:
1393:
1390:
1388:
1387:Doxifluridine
1385:
1383:
1380:
1378:
1374:
1373:
1369:
1368:
1366:
1364:
1360:
1353:
1350:
1348:
1344:
1343:
1339:
1337:
1336:Rabacfosadine
1334:
1332:
1329:
1326:
1323:
1321:
1318:
1316:
1312:
1311:
1307:
1303:
1302:
1298:
1294:
1293:
1289:
1288:
1286:
1284:
1280:
1273:
1270:
1268:
1264:
1263:
1259:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1237:
1236:
1232:
1231:
1229:
1227:
1223:
1220:
1217:
1212:
1206:
1203:
1199:
1195:
1184:
1180:
1179:
1175:
1172:
1169:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1143:
1142:
1138:
1137:
1135:
1131:
1124:
1121:
1119:
1116:
1114:
1111:
1109:
1106:
1104:
1100:
1099:
1095:
1094:
1092:
1089:
1084:
1081:
1078:
1073:
1069:
1065:
1060:
1056:
1052:
1044:
1039:
1037:
1032:
1030:
1025:
1024:
1021:
1013:
1009:
1005:
1004:
1000:
992:
991:public domain
973:
969:
967:
962:
961:"EU/3/04/186"
956:
953:
948:
944:
939:
934:
930:
926:
922:
918:
914:
907:
904:
900:
899:public domain
881:
877:
875:
870:
864:
862:
860:
858:
856:
854:
852:
850:
848:
846:
844:
840:
835:
833:
825:
819:
816:
803:
799:
795:
789:
786:
773:
772:
771:Health Canada
767:
761:
758:
755:
750:
747:
743:
739:
736:
731:
728:
715:
711:
707:
701:
698:
694:
690:
687:
682:
680:
676:
669:
667:
663:
660:
656:
654:
649:
643:
641:
639:
631:
629:
625:
623:
618:
616:
612:
608:
604:
594:
587:
581:
572:
567:
563:
556:
547:
543:
536:
532:
530:
529:Melting point
526:
519:
515:
514:
512:
509:
504:
497:
495:
491:
464:
462:
458:
453:
449:
445:
442:
440:
438:ECHA InfoCard
434:
426:
422:
421:DTXSID0026173
418:
417:
415:
406:
402:
395:
391:
390:
388:
386:
382:
375:
371:
368:
364:
363:
361:
359:
355:
348:
344:
343:
341:
339:
335:
328:
324:
323:
321:
319:
315:
308:
304:
303:
301:
299:
295:
288:
284:
283:
281:
274:
270:
263:
259:
258:
256:
254:
250:
242:
238:
233:
229:
222:
217:
210:
208: Rx-only
201:
198:
188:
186:
177:
174:
164:
163:
161:
159:
155:
150:
142:
137:
134:
133:
131:
129:
125:
122:
118:
115:
113:
107:
101:
92:
91:
89:
87:
81:
77:
73:
71:
67:
63:
55:
51:
47:
45:
41:
38:Clinical data
36:
32:
27:
19:
2870:Orphan drugs
2805:expanding it
2787:
2772:
2649:Tazemetostat
2613:Alitretinoin
2606:
2517:Estramustine
2497:Elsamitrucin
2487:Eflornithine
2441:Pegaspargase
2437:Asparaginase
2430:
2399:Testolactone
2392:
2380:
2368:
2322:
2307:Panobinostat
2290:
2260:
2248:
2236:
2224:
2195:
2160:
2148:
2101:
2097:Padeliporfin
2036:Dactinomycin
2032:Streptomyces
2013:Temozolomide
2008:Mitozolomide
1996:
1987:Mitobronitol
1976:Procarbazine
1969:
1957:Nonclassical
1882:
1874:
1859:
1853:Streptozocin
1818:Nitrosoureas
1816:
1790:Chlorambucil
1784:Trofosfamide
1770:Chlormethine
1765:Bendamustine
1758:
1696:Mitoxantrone
1691:Losoxantrone
1684:
1644:Daunorubicin
1627:
1593:
1530:Camptothecin
1518:
1474:
1444:
1430:
1413:
1397:Fluorouracil
1377:Capecitabine
1370:
1340:
1304:
1290:
1260:
1255:Pralatrexate
1245:Methotrexate
1233:
1176:
1139:
1096:
1011:
1008:"Treosulfan"
976:. Retrieved
964:
955:
920:
916:
906:
884:. Retrieved
872:
830:
818:
806:. Retrieved
797:
788:
776:. Retrieved
769:
760:
749:
730:
718:. Retrieved
709:
700:
664:
661:
657:
650:
647:
635:
632:Medical Uses
626:
619:
606:
602:
601:
590:
584:
240:
236:
158:Legal status
152:Legal status
18:
2724:from market
2694:Vorasidenib
2674:Trabectedin
2659:Tiazofurine
2654:Tebentafusp
2639:Tagraxofusp
2597:Plitidepsin
2567:Mitoguazone
2507:Epacadostat
2477:Demecolcine
2421:Aflibercept
2394:Sex steroid
2267:Fuzuloparib
2208:Carfilzomib
2180:Palbociclib
2170:Abemaciclib
2123:Verteporfin
2087:Efaproxiral
2003:Dacarbazine
1965:Altretamine
1947:Satraplatin
1942:Oxaliplatin
1922:Carboplatin
1899:Triaziquone
1870:Mannosulfan
1848:Ranimustine
1828:Fotemustine
1669:Pirarubicin
1654:Doxorubicin
1648:+cytarabine
1634:Aclarubicin
1595:Podophyllum
1520:Camptotheca
1451:Azacitidine
1437:Gemcitabine
1392:Floxuridine
1325:Fludarabine
1320:Clofarabine
1306:Halogenated
1297:Pentostatin
1272:Raltitrexed
1240:Aminopterin
1183:Ixabepilone
1178:Epothilones
1146:Cabazitaxel
1123:Vinorelbine
1108:Vincristine
1103:Vinblastine
1088:microtubule
615:fludarabine
501: g·mol
444:100.005.529
394:CHEBI:82557
219:Identifiers
121:intravenous
53:Other names
44:Trade names
2844:Categories
2689:Verdinexor
2684:Venetoclax
2587:Oblimersen
2582:Navitoclax
2557:Lucanthone
2552:Lonidamine
2542:Lifileucel
2537:Ivosidenib
2532:Imetelstat
2502:Enasidenib
2492:Elesclomol
2457:Bexarotene
2452:Belzutifan
2387:Bexarotene
2375:Atrasentan
2350:Umbralisib
2345:Idelalisib
2335:Copanlisib
2317:Vorinostat
2312:Romidepsin
2302:Entinostat
2297:Belinostat
2255:Masoprocol
2243:Tiazofurin
2231:Anagrelide
2203:Bortezomib
2190:Seliciclib
2185:Ribociclib
2165:inhibitors
2155:Tipifarnib
2118:Temoporfin
2113:Talaporfin
2051:Plicamycin
2046:Mitomycins
1992:Pipobroman
1971:Hydrazines
1937:Nedaplatin
1889:Carboquone
1884:Aziridines
1875:Treosulfan
1823:Carmustine
1810:Uramustine
1779:Ifosfamide
1751:Alkylating
1712:Bisantrene
1701:Pixantrone
1674:Valrubicin
1664:Idarubicin
1659:Epirubicin
1605:Teniposide
1560:Lurtotecan
1555:Irinotecan
1456:Decitabine
1420:Cytarabine
1363:Pyrimidine
1352:Tioguanine
1342:Thiopurine
1331:Nelarabine
1315:Cladribine
1267:Pemetrexed
1250:Pemetrexed
1226:Folic acid
1166:Paclitaxel
1118:Vinflunine
670:References
638:allogeneic
603:Treosulfan
506:3D model (
494:Molar mass
347:CO61ER3EPI
318:ChemSpider
253:CAS Number
228:IUPAC name
23:Treosulfan
2734:Phase III
2722:Withdrawn
2699:Vosaroxin
2679:Veliparib
2634:Sotorasib
2624:Selinexor
2618:Tretinoin
2608:Retinoids
2522:Glasdegib
2467:Celecoxib
2416:Adagrasib
2340:Duvelisib
2330:Alpelisib
2285:Rucaparib
2272:Niraparib
2213:Oprozomib
2175:Alvocidib
2041:Bleomycin
1998:Triazenes
1982:Etoglucid
1927:Cisplatin
1843:Nimustine
1837:Semustine
1833:Lomustine
1795:Melphalan
1722:Menogaril
1717:Crisnatol
1707:Amsacrine
1679:Zorubicin
1639:Amrubicin
1600:Etoposide
1575:Topotecan
1570:Silatecan
1565:Rubitecan
1550:Gimatecan
1535:Cositecan
1525:Belotecan
1201:inhibitor
1171:Tesetaxel
1161:Ortataxel
1156:Larotaxel
1151:Docetaxel
1113:Vindesine
720:2 January
110:Routes of
84:Pregnancy
70:Drugs.com
2767:Medicine
2572:Mitotane
2512:Eribulin
2280:Olaparib
2218:Ixazomib
1894:Thiotepa
1866:Busulfan
1545:Exatecan
1382:Carmofur
1090:assembly
1053: /
978:21 April
972:Archived
947:29557088
886:21 April
880:Archived
808:21 April
802:Archived
778:25 March
738:Archived
714:Archived
689:Archived
686:Trecondi
653:busulfan
607:Trecondi
593:(verify)
298:DrugBank
262:299-75-2
128:ATC code
117:By mouth
86:category
1501:S phase
1402:Tegafur
1216:S phase
1141:Taxanes
1077:M phase
938:6132445
644:History
461:Formula
327:8057780
307:DB11678
287:9882105
273:PubChem
183::
144:)
138: (
136:L01AB02
99: D
2753:Portal
2717:WHO-EM
2326:(Pi3K)
1283:Purine
1086:Block
945:
935:
542:SMILES
499:278.29
374:D07253
367:C19557
195:
185:℞-only
171:
2788:This
2238:IMPDI
2133:Other
968:(EMA)
876:(EMA)
834:(EMA)
827:(PDF)
798:(emc)
562:InChI
508:JSmol
385:ChEBI
2801:stub
2797:drug
2324:PIKI
2292:HDAC
1741:CCNS
980:2020
943:PMID
888:2020
810:2020
780:2024
722:2023
358:KEGG
338:UNII
66:AHFS
2792:or
2370:ERA
2226:PhI
2197:PrI
2162:CDK
2074:PDT
1072:MIs
1068:SPs
1059:L01
933:PMC
925:doi
410:EPA
277:CID
197:POM
141:WHO
2846::
2730::
2250:LI
2150:FI
1616:II
1586:II
1408:))
1010:.
963:.
941:.
931:.
921:57
919:.
915:.
871:.
842:^
829:.
800:.
796:.
768:.
708:.
678:^
475:14
239:,3
235:(2
204:EU
191:UK
180:CA
173:S4
167:AU
119:,
95:AU
2832:e
2825:t
2818:v
2807:.
2755::
2620:)
2611:(
2443:)
2439:/
2435:(
2401:)
2397:(
2389:)
2385:(
2377:)
2373:(
2352:)
2328:(
2319:)
2295:(
2287:)
2265:(
2257:)
2253:(
2245:)
2241:(
2233:)
2229:(
2192:)
2168:(
2157:)
2153:(
2125:)
2106:(
2072:/
2053:)
2034:(
2015:)
2001:(
1978:)
1974:(
1886::
1877:)
1868:(
1863::
1839:)
1835:(
1820::
1801:)
1797:(
1786:)
1777:(
1762::
1743:)
1739:(
1703:)
1689:(
1681:)
1650:)
1646:(
1632:(
1618:+
1607:)
1598:(
1577:)
1523:(
1511:I
1503:)
1499:(
1483:)
1479:(
1458:)
1449:(
1439:)
1435:(
1425:)
1418:(
1404:(
1375:(
1354:)
1345:(
1327:)
1313:(
1308:/
1299:)
1295:(
1274:)
1265:(
1257:)
1238:(
1218:)
1214:(
1185:)
1181:(
1173:)
1144:(
1125:)
1101:(
1079:)
1075:(
1070:/
1061:)
1057:(
1042:e
1035:t
1028:v
1014:.
993:.
982:.
949:.
927::
901:.
890:.
812:.
782:.
724:.
510:)
487:2
484:S
481:8
478:O
472:H
469:6
466:C
412:)
408:(
241:S
237:S
206::
193::
169::
97::
68:/
58:L
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
