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can be used to buffer the solution to a pH range of 6.5-7.5. Usually an equal amount of buffer is added to attain a neutral pH. In salt/marine/sea water, the buffer use may not be necessary because sea water itself has buffering capacity . The solution of TMS needs to be prepared freshly each time
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because TMS is light-sensitive and might form toxic by-products upon exposure to light . Fish treated with
Tricaine cannot be slaughtered for human consumption until a certain withdrawal period is reached, for example 21 days in the United States for Syncaine.
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MSD Animal Health is one of the largest manufacturers of
Tricaine in Norway and other European markets under the brand name Finquel. The largest manufacturer of Tricaine in North America is Syndel under the brand name Syncaine. Syncaine is manufactured in
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Wayson KA, Downes H, Lynn RK, Gerber N (September 1976). "Studies on the comparative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selective toxicity in poikilotherms".
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462:, and other cold-blooded animals during manual spawning, as well as during marking, measuring, photography, research, surgical operations, transport, and weighing of fish.
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of fish. TMS is the only anesthetic licensed in the United States for fin fish that are intended for human consumption. The drug can have selective toxicity for
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Tricaine is an anaesthetic that operates by preventing sodium ions to enter the cell and thus silencing
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The optimum concentration may vary with the size and species of the fish, and other variables.
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InChI=1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4)
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It is easily soluble in water (both fresh and salt) but it drastically decreases the
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Brown C, Pavek T. "Fish and
Amphibian Euthanasia". In Bowser P (ed.).
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597:"Tricaine-S (MS-222) Fish Anesthetic | Aqualife TMS Fish Sedative"
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446:. This has the net effect of blocking signal exchange between the
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of water, increasing the acidity, which may be toxic for fish.
525:"A review of tricaine methanesulfonate for anesthesia of fish"
458:, in the United States. Syncaine is used for handling fish,
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The
Journal of Pharmacology and Experimental Therapeutics
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due to their lower rate of metabolism in the liver.
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32:"MS-222" redirects here. For other uses, see
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120:Ethyl 3-aminobenzoate methanesulfonic acid
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572:"MSD ANIMAL HEALTH ACQUIRES SCAN AQUA AS"
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522:Carter KM, Woodley CM, Brown RS (2011).
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530:Reviews in Fish Biology and Fisheries
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629:. Cornell University. Archived from
623:Animal Care and Use Procedure (ACUP)
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648:"Approved Aquaculture Drugs FDA"
359:C1=CC=CC(C(OCC)=O)=C1.CS(=O)()=O
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384:Key:FQZJYWMRQDKBQN-UHFFFAOYSA-N
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1:
425:MS-222, Syncaine, Tricaine-S,
343:149.5 °C (301.1 °F)
653:Food and Drug Administration
427:), is white powder used for
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265:Chemical and physical data
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550:10.1007/s11160-010-9188-0
417:Tricaine methanesulfonate
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456:Ferndale, Washington
674:General anesthetics
542:2011RFBF...21...51C
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474:Sodium bicarbonate
450:and extremities.
444:action potentials
413:Tricaine mesylate
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328:Interactive image
215:CompTox Dashboard
41:Tricaine mesylate
27:Chemical compound
16:(Redirected from
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604:. Retrieved
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580:. Retrieved
578:. 2019-03-05
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536:(1): 51–59.
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29:
311: g·mol
254:100.011.779
104:Identifiers
80:ATCvet code
61:Other names
668:Categories
606:2019-12-12
582:2022-06-06
576:Fish Focus
481:References
460:amphibians
433:euthanasia
429:anesthesia
316:3D model (
304:Molar mass
204:971ZM8IPK1
175:ChemSpider
130:CAS Number
113:IUPAC name
66:Metacaine
558:39693748
403:(verify)
139:886-86-2
88:QN01AX93
68:Tricaine
64:Syncaine
18:Tricaine
538:Bibcode
271:Formula
150:PubChem
96:)
90: (
72:Finquel
601:Syndel
556:
509:185356
507:
352:SMILES
309:261.29
70:MS-222
634:(PDF)
627:(PDF)
554:S2CID
448:brain
372:InChI
318:JSmol
184:12878
164:13454
34:MS222
505:PMID
195:UNII
546:doi
501:198
421:TMS
220:EPA
154:CID
93:WHO
74:TMS
670::
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534:21
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470:pH
423:,
419:,
285:15
279:10
609:.
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415:(
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297:S
294:5
291:O
288:N
282:H
276:C
222:)
218:(
36:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
