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can be used to buffer the solution to a pH range of 6.5-7.5. Usually an equal amount of buffer is added to attain a neutral pH. In salt/marine/sea water, the buffer use may not be necessary because sea water itself has buffering capacity . The solution of TMS needs to be prepared freshly each time
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because TMS is light-sensitive and might form toxic by-products upon exposure to light . Fish treated with
Tricaine cannot be slaughtered for human consumption until a certain withdrawal period is reached, for example 21 days in the United States for Syncaine.
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MSD Animal Health is one of the largest manufacturers of
Tricaine in Norway and other European markets under the brand name Finquel. The largest manufacturer of Tricaine in North America is Syndel under the brand name Syncaine. Syncaine is manufactured in
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Wayson KA, Downes H, Lynn RK, Gerber N (September 1976). "Studies on the comparative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selective toxicity in poikilotherms".
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451:, and other cold-blooded animals during manual spawning, as well as during marking, measuring, photography, research, surgical operations, transport, and weighing of fish.
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of fish. TMS is the only anesthetic licensed in the United States for fin fish that are intended for human consumption. The drug can have selective toxicity for
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Tricaine is an anaesthetic that operates by preventing sodium ions to enter the cell and thus silencing
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The optimum concentration may vary with the size and species of the fish, and other variables.
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InChI=1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4)
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It is easily soluble in water (both fresh and salt) but it drastically decreases the
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Brown C, Pavek T. "Fish and
Amphibian Euthanasia". In Bowser P (ed.).
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586:"Tricaine-S (MS-222) Fish Anesthetic | Aqualife TMS Fish Sedative"
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435:. This has the net effect of blocking signal exchange between the
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of water, increasing the acidity, which may be toxic for fish.
514:"A review of tricaine methanesulfonate for anesthesia of fish"
447:, in the United States. Syncaine is used for handling fish,
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The
Journal of Pharmacology and Experimental Therapeutics
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due to their lower rate of metabolism in the liver.
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21:"MS-222" redirects here. For other uses, see
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109:Ethyl 3-aminobenzoate methanesulfonic acid
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561:"MSD ANIMAL HEALTH ACQUIRES SCAN AQUA AS"
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511:Carter KM, Woodley CM, Brown RS (2011).
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519:Reviews in Fish Biology and Fisheries
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618:. Cornell University. Archived from
612:Animal Care and Use Procedure (ACUP)
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637:"Approved Aquaculture Drugs FDA"
348:C1=CC=CC(C(OCC)=O)=C1.CS(=O)()=O
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373:Key:FQZJYWMRQDKBQN-UHFFFAOYSA-N
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414:MS-222, Syncaine, Tricaine-S,
332:149.5 °C (301.1 °F)
642:Food and Drug Administration
416:), is white powder used for
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254:Chemical and physical data
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539:10.1007/s11160-010-9188-0
406:Tricaine methanesulfonate
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445:Ferndale, Washington
663:General anesthetics
531:2011RFBF...21...51C
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463:Sodium bicarbonate
439:and extremities.
433:action potentials
402:Tricaine mesylate
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317:Interactive image
204:CompTox Dashboard
30:Tricaine mesylate
16:Chemical compound
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593:. Retrieved
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569:. Retrieved
567:. 2019-03-05
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525:(1): 51–59.
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18:
300: g·mol
243:100.011.779
93:Identifiers
69:ATCvet code
50:Other names
657:Categories
595:2019-12-12
571:2022-06-06
565:Fish Focus
470:References
449:amphibians
422:euthanasia
418:anesthesia
305:3D model (
293:Molar mass
193:971ZM8IPK1
164:ChemSpider
119:CAS Number
102:IUPAC name
55:Metacaine
547:39693748
392:(verify)
128:886-86-2
77:QN01AX93
57:Tricaine
53:Syncaine
527:Bibcode
260:Formula
139:PubChem
85:)
79: (
61:Finquel
590:Syndel
545:
498:185356
496:
341:SMILES
298:261.29
59:MS-222
623:(PDF)
616:(PDF)
543:S2CID
437:brain
361:InChI
307:JSmol
173:12878
153:13454
23:MS222
494:PMID
184:UNII
535:doi
490:198
410:TMS
209:EPA
143:CID
82:WHO
63:TMS
659::
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523:21
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459:pH
412:,
408:,
274:15
268:10
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404:(
309:)
286:S
283:5
280:O
277:N
271:H
265:C
211:)
207:(
25:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
