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Tropical spastic paraparesis

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Treatment of TSP involves corticosteroids to help with inflammation. Though any success with corticosteroids is short-lived, with symptoms worsened as the dosage is reduced. A synthetic derivative, 17-alpha-ethinyltestosterone, can be used to treat tropical spastic paraparesis, improvement in motor
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Often, the diagnosis process is based on symptoms and one's risk of exposure to the virus. A spinal tap or lumbar puncture may be used to obtain blood and CSF samples which can then be tested for parts of the virus or antibodies produced to combat the virus. MRI may be performed on the brain and
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monoclonal antibody, is also being researched as a possible treatment for tropical spastic paraparesis. The antibody reduces HTLV-1 proviral load and production of proinflammatory cytokines. Valproic acid has also succeeded in reducing the proviral load of HTLV-1 (though clinical benefits were
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In tropical spastic paraparesis, HTLV-1 shows elevated cellular acquired immune response as well as high production of proinflammatory cytokines. IFN overexpression has been demonstrated as well. Also the number of NK cells (CD56+ and CD16+) is diminished.
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The prognosis for tropical spastic paraparesis indicates some improvement in a percentage of cases due to immunosuppressive treatment. A higher percentage will eventually lose the ability to walk within a ten-year interval.
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was used to describe a chronic and progressive clinical syndrome that affected adults living in equatorial areas of the world. This condition was initially thought to be associated with infectious agents (such as
643: 367:(TAN) and tropical spastic paraparesis (TSP). They are placed together because they are found in tropical countries, although tropical spastic paraparesis has occurred in temperate countries (e.g., Japan). 723: 828: 1874: 530: 508: 1297: 651: 1888: 1247: 1102: 1554: 1385: 812: 1425: 1290: 1518: 1575: 1240: 822: 475: 1894: 1420: 1377: 1095: 616: 580: 311:
minimal or none). A further combination of valproic acid and zidovudine has demonstrated a decrease in proviral loads (in animals).
1809: 538: 500: 1880: 1283: 644:"HTLV-1 associated myelopathy/tropical spastic paraparesis | Disease | Overview | Office of Rare Diseases Research (ORDR-NCATS)" 1257: 1479: 1465: 1262: 235: 1678: 1589: 1583: 1473: 1088: 156: 97: 2047: 1973: 1967: 1640: 907:"Human T Lymphotropic Virus Type-1-associated Myelopathy Manifesting Shortly after Living-donor Renal Transplantation" 364: 360: 243: 136: 674:"Clinical Pathophysiology of Human T-Lymphotropic Virus-Type 1-Associated Myelopathy/Tropical Spastic Paraparesis" 2104: 1711: 1152: 253:
HTLV-1 can be transmitted via breastfeeding (mother to child), sexual contact, via blood contact (transfusion or
531:"Tropical Spastic Paraparesis Information Page: National Institute of Neurological Disorders and Stroke (NINDS)" 286:
spinal cord to check for abnormalities such as spinal cord degeneration and other potential causes of symptoms.
1813: 1725: 1630: 1460: 1433: 1405: 1338: 977: 413:"Treatment of HTLV-I-Associated Myelopathy / Tropical Spastic Paraparesis: Towards Rational Targeted Therapy" 2297: 1609: 1157: 1136: 1071: 1803: 1399: 1039: 2003: 1981: 1860: 1856: 1852: 1848: 1741: 1635: 1596: 1162: 346: 501:"Tropical Spastic Paraparesis Information Page | National Institute of Neurological Disorders and Stroke" 1988: 1569: 1439: 1193: 1172: 1167: 1410: 2252: 2084: 1719: 1548: 1225: 75: 1670: 1391: 1252: 1198: 1773: 1529: 376: 341: 335: 84: 1275: 2237: 2188: 2169: 2150: 1940: 1936: 1932: 1928: 1845: 1750: 1454: 1332: 988: 928: 893: 818: 776: 705: 612: 572: 442: 152: 105: 64: 2212: 1922: 1602: 1534: 1415: 1346: 1210: 918: 883: 766: 695: 685: 432: 424: 386: 1028: 905:
Nagamine, Yuito; Hayashi, Takeshi; Kato, Yuji; Horiuchi, Yohsuke; Tanahashi, Norio (2015).
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Among the methods of diagnosing tropical spastic paraparesis are
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Machigashira, N.; Yoshida, Y.; Wang, S.-y.; Osame, M. (2001).
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HTLV-I-associated myelopathy/tropical spastic paraparesis
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and bladder function was reported but not sustainable.
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Some of the signs of Tropical spastic paraparesis are:
349:) and with chronic nutritional deficiencies (such as 944: 2251: 2227: 2135: 2058: 2013: 2002: 1831: 1793: 1772: 1740: 1695: 1649: 1528: 1517: 1490: 1317: 1181: 1145: 1119: 1003: 948: 114: 104: 93: 83: 63: 26: 21: 411:Oh, Unsong; Jacobson, Steven (23 December 2016). 131:), is a medical condition that causes weakness, 230:(inflammation of the uveal tract of the eye), 159:(HTLV-1) antibodies, as a preventive measure. 1291: 1248:Subacute combined degeneration of spinal cord 1096: 8: 795:Human T-Cell Lymphotropic Viruses~treatment 2010: 1790: 1555:Progressive multifocal leukoencephalopathy 1525: 1298: 1284: 1276: 1103: 1089: 1081: 945: 559:Centers for Disease Control (CDC) (1988). 363:are classified as two separate syndromes: 74: 50: 18: 1426:Extranodal NK/T-cell lymphoma, nasal type 922: 887: 770: 699: 689: 436: 672:Yamano, Yoshihisa; Sato, Tomoo (2012). 403: 234:(inflammation of one or more joints), 226:Individuals with TSP may also exhibit 734:from the original on 28 February 2023 495: 493: 478:from the original on 29 November 2017 462: 460: 458: 456: 7: 511:from the original on 23 October 2018 238:(inflammation of the lung tissues), 1576:Subacute sclerosing panencephalitis 811:Prayson, Richard A. (2011-11-15). 608:Neurology: A Queen Square Textbook 605:; Shorvon, Simon D. (2011-09-09). 345:, which cause inflammation of the 242:(an inflammatory muscle disease), 14: 1895:Severe acute respiratory syndrome 1421:Follicular dendritic cell sarcoma 278:(magnetic resonance imaging) and 118:Interferon alpha, corticosteroids 1881:Middle East respiratory syndrome 1054: 924:10.2169/internalmedicine.54.2950 601:Clarke, Charles; Howard, Robin; 282:(which may show lymphocytosis). 236:pulmonary lymphocytic alveolitis 1258:Anterior spinal artery syndrome 831:from the original on 2023-01-11 772:10.1590/S0043-31442006000600023 625:from the original on 2023-01-11 583:from the original on 2019-04-03 1480:Adult T-cell leukemia/lymphoma 1466:Splenic marginal zone lymphoma 328:For several decades, the term 1: 728:Merck Manual Consumer Version 135:, and sensory disturbance by 1685:Tropical spastic paraparesis 1590:Lymphocytic choriomeningitis 1206:Tropical spastic paraparesis 1072:Tropical spastic paraparesis 1029:Tropical spastic paraparesis 817:. Elsevier Health Sciences. 330:tropical spastic paraparesis 306:Mogamulizumab, an anti-CCR4 250:(inflammation of the skin). 157:human T-lymphotropic virus 1 125:Tropical spastic paraparesis 31:HTLV-I-associated myelopathy 22:Tropical spastic paraparesis 2048:Cytomegalovirus esophagitis 1968:Human parainfluenza viruses 1641:Ramsay Hunt syndrome type 2 759:West Indian Medical Journal 2314: 850:Tropical Myeloneuropathies 365:tropical ataxic neuropathy 361:Tropical myeloneuropathies 244:keratoconjunctivitis sicca 155:products are screened for 137:human T-lymphotropic virus 1712:Cytomegalovirus retinitis 1263:Foix–Alajouanine syndrome 678:Frontiers in Microbiology 648:rarediseases.info.nih.gov 611:. John Wiley & Sons. 429:10.1016/j.ncl.2008.03.008 58: 49: 1814:Infectious mononucleosis 1631:Chandipura vesiculovirus 1461:Hepatocellular carcinoma 1406:Nasopharyngeal carcinoma 1339:Hepatocellular carcinoma 691:10.3389/fmicb.2012.00389 1610:Encephalitis lethargica 1311:viral systemic diseases 1158:Posterior cord syndrome 1137:Spinal cord compression 59:HTLV-1 which causes TSP 1982:Human orthopneumovirus 1636:Herpesviral meningitis 1597:Arbovirus encephalitis 1163:Anterior cord syndrome 1153:Brown-SĂ©quard syndrome 347:central nervous system 299: 175: 1440:Merkel-cell carcinoma 1194:Demyelinating disease 1173:Cauda equina syndrome 1168:Central cord syndrome 1111:Focal lesions of the 571:(48): 736–40, 745–7. 297: 248:infectious dermatitis 173: 2085:Adenovirus infection 1549:Human polyomavirus 2 1378:Oropharyngeal cancer 889:10.1212/WNL.56.1.104 196:Urinary dysfunction. 110:Lumbar puncture, MRI 1671:Post-polio syndrome 1307:Infectious diseases 1253:Vascular myelopathy 1199:Transverse myelitis 100:causes 80% of cases 1804:Epstein–Barr virus 1774:Respiratory system 1411:Burkitt's lymphoma 1004:External resources 377:Treponema pallidum 342:Treponema pallidum 336:Treponema pertenue 300: 176: 163:Signs and symptoms 2285: 2284: 2247: 2246: 1998: 1997: 1929:Influenza virus A 1846:Human coronavirus 1736: 1735: 1726:Herpes of the eye 1273: 1272: 1226:Morvan's syndrome 1049: 1048: 911:Internal Medicine 535:www.ninds.nih.gov 505:www.ninds.nih.gov 205:Erectile problems 199:Bowel dysfunction 153:Blood transfusion 122: 121: 106:Diagnostic method 98:HTLV-1 retrovirus 89:Bowel dysfunction 16:Medical condition 2305: 2011: 2006:digestive system 1923:Orthomyxoviridae 1889:SARS coronavirus 1875:MERS coronavirus 1791: 1603:Orthomyxoviridae 1526: 1492:Immune disorders 1416:Hodgkin lymphoma 1392:Kaposi's sarcoma 1300: 1293: 1286: 1277: 1211:Epidural abscess 1105: 1098: 1091: 1082: 1058: 1057: 946: 936: 926: 901: 891: 857: 846: 840: 839: 837: 836: 808: 802: 791: 785: 784: 774: 750: 744: 743: 741: 739: 720: 714: 713: 703: 693: 669: 663: 662: 660: 659: 650:. 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Index


Specialty
Neurology
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Symptoms
HTLV-1 retrovirus
Diagnostic method
muscle spasms
human T-lymphotropic virus
paraparesis
tropical regions
Caribbean
Blood transfusion
human T-lymphotropic virus 1

uveitis
arthritis
pulmonary lymphocytic alveolitis
polymyositis
keratoconjunctivitis sicca
infectious dermatitis
needle sharing
MRI
lumbar puncture

IgG1
Treponema pertenue
Treponema pallidum
central nervous system
avitaminosis

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