325:
302:
199:
224:
2112:
576:
331:
230:
36:
2898:
2918:
1126:
Its malfunction acts in an autosomal dominant manner to cause pancreatitis. Many mutations that can lead to pancreatitis have been found. An example is a mutation at Arg 117. Arg 117 is a trypsin-sensitive site which can be cleaved by another trypsin and becomes inactivated. This site may be a
62:
1414:
Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD (1996). "Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene".
1127:
fail-safe mechanism by which trypsin, when activated within the pancreas, may become inactivated. Mutation at this cleavage site would result in a loss of control and permit autodigestion, causing pancreatitis.
1463:
Chen JM, Ferec C (2000). "Gene conversion-like missense mutations in the human cationic trypsinogen gene and insights into the molecular evolution of the human trypsinogen family".
2552:
2412:
2111:
338:
237:
1492:
Chen JM, Montier T, FĂ©rec C (2001). "Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations".
2152:
1597:"Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B."
1767:
Honey NK, Sakaguchi AY, Quinto C, et al. (1984). "Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase".
1738:
Emi M, Nakamura Y, Ogawa M, et al. (1986). "Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens".
2056:
789:
160:
770:
1102:. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the
2992:
1216:
2963:
2091:
1806:"Limited tryptic digestion near the amino terminus of bovine liver rhodanese produces active electrophoretic variants with altered refolding"
1198:
2982:
2145:
993:
324:
1884:
Gaboriaud C, Serre L, Guy-Crotte O, et al. (1996). "Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151".
2617:
1000:
20:
1301:
1284:
301:
1950:"Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties"
1234:
1185:
1164:
2138:
2773:
1991:
Dahlen JR, Foster DC, Kisiel W (1998). "Expression, purification, and inhibitory properties of human proteinase inhibitor".
1181:
223:
198:
59:
1160:
2888:
2372:
140:
2130:
337:
236:
1839:
Rowen L, Koop BF, Hood L (1996). "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus".
2758:
1709:
Kimland M, Russick C, Marks WH, Borgström A (1990). "Immunoreactive anionic and cationic trypsin in human serum".
1631:"CD4-binding regions of human immunodeficiency virus envelope glycoprotein gp120 defined by proteolytic digestion"
330:
229:
2956:
2874:
2861:
2848:
2835:
2822:
2809:
2796:
2287:
2272:
2172:
2084:
1118:. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
2768:
2722:
2665:
2169:
838:
148:
2670:
2562:
2527:
2522:
1529:
Howes N, Greenhalf W, Stocken DD, Neoptolemos JP (2005). "Cationic trypsinogen mutations and pancreatitis".
819:
815:
1375:"Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis"
2691:
2610:
2517:
2367:
2763:
2949:
2507:
2077:
1848:
212:
127:
2727:
2407:
2397:
2214:
2209:
976:
929:
2987:
2660:
1872:
1792:
1583:
1517:
1440:
1314:
172:
955:
908:
2389:
2033:
2008:
1979:
1936:
1901:
1864:
1827:
1784:
1755:
1726:
1697:
1662:
1617:
1575:
1546:
1509:
1480:
1432:
1396:
1355:
1306:
1265:
120:
52:
2933:
2706:
2701:
2675:
2603:
2181:
2000:
1969:
1961:
1926:
1893:
1856:
1817:
1776:
1747:
1718:
1687:
1652:
1642:
1607:
1567:
1538:
1501:
1472:
1424:
1386:
1345:
1296:
1257:
417:
348:
292:
247:
575:
168:
2753:
2737:
2650:
2422:
2417:
2189:
2165:
1099:
392:
1852:
2902:
2791:
2732:
1974:
1949:
1103:
35:
1822:
1805:
1692:
1675:
1612:
1596:
704:
699:
694:
689:
673:
668:
663:
658:
653:
637:
632:
627:
622:
617:
2976:
2696:
2655:
2567:
2440:
2429:
2161:
2060:
2042:
1751:
1722:
1657:
1630:
1391:
1374:
604:
1876:
1796:
1587:
1558:
Kandula L, Whitcomb DC, Lowe ME (2006). "Genetic issues in pediatric pancreatitis".
1521:
1444:
1318:
1248:
Rebours V, LĂ©vy P, Ruszniewski P (2011). "An overview of hereditary pancreatitiss".
152:
2929:
2645:
2463:
2357:
2199:
1115:
410:
189:
2120:: CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTED PHOSPHORYLATION OF TYROSINE 151
1860:
176:
2869:
2804:
2640:
2582:
2577:
2226:
1221:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1203:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1075:
2897:
2027:
493:
2544:
2486:
2267:
2262:
2242:
1571:
1542:
1261:
309:
206:
156:
1931:
1914:
1647:
2843:
2817:
2572:
2558:
2377:
2257:
2247:
1350:
1333:
1161:
ENSG00000204983 GRCh38: Ensembl release 89: ENSG00000274247, ENSG00000204983
734:
553:
431:
376:
363:
275:
262:
164:
1897:
1579:
1550:
1513:
1484:
1476:
1359:
1269:
131:, TRP1, TRY1, TRY4, TRYP1, Trypsin 1, protease, serine 1, serine protease 1
2012:
1983:
1940:
1905:
1868:
1831:
1788:
1759:
1730:
1701:
1666:
1621:
1505:
1436:
1400:
1310:
1040:
1035:
2458:
2453:
2402:
2252:
2237:
2204:
1111:
1024:
883:
864:
2512:
2502:
2448:
2362:
2194:
2047:
2037:
1780:
1428:
1136:
1095:
1071:
1060:
850:
801:
2028:
GeneReviews/NCBI/NIH/UW entry on PRSS1-Related
Hereditary Pancreatitis
2004:
1965:
1302:
10.1002/(SICI)1098-1004(1998)12:1<39::AID-HUMU6>3.0.CO;2-P
97:
93:
89:
85:
81:
2856:
2626:
2539:
2481:
1107:
1008:
756:
2917:
2830:
2548:
2534:
2473:
2347:
2342:
2337:
2332:
2327:
2322:
1285:"Mutations of the cationic trypsinogen in hereditary pancreatitis"
1083:
1079:
719:
715:
2925:
2317:
2312:
2307:
2302:
2297:
2292:
2282:
2277:
1067:
144:
2599:
2134:
2073:
1948:
Christensen S, Valnickova Z, Thogersen IB, et al. (1997).
584:
2069:
2032:
Overview of all the structural information available in the
1915:"The properties of the protein tyrosine phosphatase PTPMEG"
19:"PRSS1" redirects here. For the outer space satellite, see
2595:
1094:
This gene encodes a trypsinogen, which is a member of the
1114:. Mutations in this gene are associated with hereditary
400:
2937:
1373:
Gorry MC, Gabbaizedeh D, Furey W, et al. (1997).
2886:
1595:
Yamamoto KK, Pousette A, Chow P, et al. (1992).
565:
1235:"Entrez Gene: PRSS1 protease, serine, 1 (trypsin 1)"
2782:
2746:
2715:
2684:
2633:
2495:
2472:
2438:
2388:
2225:
2180:
969:
948:
922:
901:
1177:
1175:
1173:
1156:
1154:
1152:
1629:Pollard SR, Meier W, Chow P, et al. (1992).
347:
246:
1676:"The reactive site of human alpha 2-antiplasmin"
16:Protein-coding gene in the species Homo sapiens
1182:GRCm38: Ensembl release 89: ENSMUSG00000071521
2957:
2611:
2146:
2085:
8:
1334:"Molecular basis of hereditary pancreatitis"
2964:
2950:
2618:
2604:
2596:
2153:
2139:
2131:
2092:
2078:
2070:
2057:United States National Library of Medicine
1804:Merrill GA, Butler M, Horowitz PM (1993).
730:
600:
388:
287:
184:
70:
1973:
1930:
1821:
1691:
1656:
1646:
1611:
1390:
1349:
1300:
2055:This article incorporates text from the
674:collagen-containing extracellular matrix
2893:
2107:
1148:
2166:serine proteases/serine endopeptidases
25:
1078:secreted by pancreas, the others are
352:
313:
308:
251:
210:
205:
7:
2914:
2912:
1283:Teich N, Mössner J, Keim V (1998).
2936:. You can help Knowledge (XXG) by
966:
945:
919:
898:
874:
855:
829:
806:
780:
761:
623:serine-type endopeptidase activity
570:
488:
426:
405:
14:
1063:that in humans is encoded by the
21:Pakistan Remote Sensing Satellite
2916:
2896:
2110:
1560:Current Gastroenterology Reports
1392:10.1053/gast.1997.v113.pm9322498
700:extracellular matrix disassembly
574:
336:
329:
323:
300:
235:
228:
222:
197:
34:
638:serine-type peptidase activity
585:More reference expression data
554:More reference expression data
1:
2993:Human chromosome 7 gene stubs
2378:Urinary plasminogen activator
1861:10.1126/science.272.5269.1755
1823:10.1016/S0021-9258(18)82300-6
1693:10.1016/S0021-9258(18)45536-6
1613:10.1016/S0021-9258(18)45919-4
321:
220:
2373:Tissue plasminogen activator
1752:10.1016/0378-1119(86)90111-3
1723:10.1016/0009-8981(89)90254-4
1635:Proc. Natl. Acad. Sci. U.S.A
2983:Genes on human chromosome 7
1674:Shieh BH, Travis J (1987).
1250:Digestive and Liver Disease
1082:(anionic trypsinogen), and
695:cobalamin metabolic process
3009:
2911:
18:
2774:Michaelis–Menten kinetics
2464:Proteinase 3/Myeloblastin
2105:
2046:(Human Trypsin-1) at the
1913:Gu M, Majerus PW (1996).
1572:10.1007/s11894-006-0083-8
1543:10.1016/j.cll.2004.12.004
1332:Chen JM, Ferec C (2000).
1262:10.1016/j.dld.2011.08.003
1217:"Mouse PubMed Reference:"
1199:"Human PubMed Reference:"
1070:. Trypsin-1 is the main
1039:
1034:
1030:
1023:
1007:
994:Chr 7: 142.75 – 142.75 Mb
988:
973:
952:
941:
926:
905:
894:
881:
877:
862:
858:
849:
836:
832:
813:
809:
800:
787:
783:
768:
764:
755:
740:
733:
729:
713:
603:
599:
582:
573:
564:
551:
536:quadriceps femoris muscle
500:
491:
438:
429:
399:
391:
387:
370:
357:
320:
299:
290:
286:
269:
256:
219:
196:
187:
183:
138:
135:
125:
118:
113:
78:
73:
56:
51:
46:
42:
33:
28:
2666:Diffusion-limited enzyme
1932:10.1074/jbc.271.44.27751
1648:10.1073/pnas.88.24.11320
1351:10.1038/sj.ejhg.5200492
1001:Chr 6: 41.33 – 41.33 Mb
2518:Proprotein convertases
1898:10.1006/jmbi.1996.0376
1769:Somat. Cell Mol. Genet
1477:10.1006/mgme.2000.3086
2759:Eadie–Hofstee diagram
2692:Allosteric regulation
2368:Plasminogen activator
1506:10.1007/s004390100580
1122:Clinical significance
664:extracellular exosome
466:right coronary artery
2769:Lineweaver–Burk plot
2508:Prolyl endopeptidase
1086:(meso-trypsinogen).
1057:cationic trypsinogen
654:extracellular region
315:Chromosome 6 (mouse)
213:Chromosome 7 (human)
74:List of PDB id codes
47:Available structures
1853:1996Sci...272.1755R
669:extracellular space
659:blood microparticle
508:islet of Langerhans
478:right lobe of liver
446:islet of Langerhans
2924:This article on a
2728:Enzyme superfamily
2661:Enzyme promiscuity
2059:, which is in the
1781:10.1007/BF01535632
1429:10.1038/ng1096-141
1338:Eur. J. Hum. Genet
839:ENSMUSG00000071521
683:Biological process
647:Cellular component
628:hydrolase activity
618:peptidase activity
611:Molecular function
2945:
2944:
2884:
2883:
2593:
2592:
2390:Complement system
2182:Digestive enzymes
2128:
2127:
2005:10.1021/bi970977p
1966:10.1042/bj3230847
1847:(5269): 1755–62.
1465:Mol. Genet. Metab
1050:
1049:
1046:
1045:
1019:
1018:
984:
983:
963:
962:
937:
936:
916:
915:
890:
889:
871:
870:
845:
844:
826:
825:
796:
795:
777:
776:
725:
724:
633:metal ion binding
595:
594:
591:
590:
560:
559:
547:
546:
485:
484:
474:left uterine tube
383:
382:
282:
281:
177:PRSS1 - orthologs
109:
108:
105:
104:
57:Ortholog search:
3000:
2966:
2959:
2952:
2920:
2913:
2901:
2900:
2892:
2764:Hanes–Woolf plot
2707:Enzyme activator
2702:Enzyme inhibitor
2676:Enzyme catalysis
2620:
2613:
2606:
2597:
2155:
2148:
2141:
2132:
2114:
2094:
2087:
2080:
2071:
2016:
1999:(48): 14874–82.
1987:
1977:
1960:(Pt 3): 847–52.
1944:
1934:
1909:
1880:
1835:
1825:
1816:(21): 15611–20.
1800:
1763:
1734:
1711:Clin. Chim. Acta
1705:
1695:
1670:
1660:
1650:
1625:
1615:
1591:
1554:
1525:
1488:
1449:
1448:
1411:
1405:
1404:
1394:
1379:Gastroenterology
1370:
1364:
1363:
1353:
1329:
1323:
1322:
1304:
1280:
1274:
1273:
1245:
1239:
1238:
1231:
1225:
1224:
1213:
1207:
1206:
1195:
1189:
1179:
1168:
1158:
1100:serine proteases
1055:, also known as
1032:
1031:
1003:
996:
979:
967:
958:
946:
942:RefSeq (protein)
932:
920:
911:
899:
875:
856:
830:
807:
781:
762:
731:
601:
587:
578:
571:
556:
496:
494:Top expressed in
489:
442:body of pancreas
434:
432:Top expressed in
427:
406:
389:
379:
366:
355:
340:
333:
327:
316:
304:
288:
278:
265:
254:
239:
232:
226:
215:
201:
185:
179:
130:
123:
100:
71:
65:
44:
43:
38:
26:
3008:
3007:
3003:
3002:
3001:
2999:
2998:
2997:
2973:
2972:
2971:
2970:
2909:
2907:
2895:
2887:
2885:
2880:
2792:Oxidoreductases
2778:
2754:Enzyme kinetics
2742:
2738:List of enzymes
2711:
2680:
2651:Catalytic triad
2629:
2624:
2594:
2589:
2491:
2468:
2434:
2384:
2221:
2190:Enteropeptidase
2176:
2159:
2129:
2124:
2121:
2115:
2101:
2098:
2067:
2024:
2019:
1990:
1947:
1925:(44): 27751–9.
1912:
1892:(5): 995–1010.
1883:
1838:
1803:
1766:
1746:(2–3): 305–10.
1737:
1708:
1673:
1641:(24): 11320–4.
1628:
1594:
1557:
1528:
1491:
1462:
1458:
1456:Further reading
1453:
1452:
1417:Nature Genetics
1413:
1412:
1408:
1372:
1371:
1367:
1331:
1330:
1326:
1282:
1281:
1277:
1247:
1246:
1242:
1233:
1232:
1228:
1215:
1214:
1210:
1197:
1196:
1192:
1180:
1171:
1159:
1150:
1145:
1133:
1124:
1092:
1041:View/Edit Mouse
1036:View/Edit Human
999:
992:
989:Location (UCSC)
975:
954:
928:
907:
820:ENSG00000204983
818:
816:ENSG00000274247
709:
678:
642:
583:
552:
543:
538:
534:
530:
526:
522:
518:
514:
510:
506:
492:
481:
476:
472:
468:
464:
460:
456:
454:body of stomach
452:
448:
444:
430:
374:
361:
353:
343:
342:
341:
334:
314:
291:Gene location (
273:
260:
252:
242:
241:
240:
233:
211:
188:Gene location (
139:
126:
119:
80:
58:
24:
17:
12:
11:
5:
3006:
3004:
2996:
2995:
2990:
2985:
2975:
2974:
2969:
2968:
2961:
2954:
2946:
2943:
2942:
2921:
2906:
2905:
2882:
2881:
2879:
2878:
2865:
2852:
2839:
2826:
2813:
2800:
2786:
2784:
2780:
2779:
2777:
2776:
2771:
2766:
2761:
2756:
2750:
2748:
2744:
2743:
2741:
2740:
2735:
2730:
2725:
2719:
2717:
2716:Classification
2713:
2712:
2710:
2709:
2704:
2699:
2694:
2688:
2686:
2682:
2681:
2679:
2678:
2673:
2668:
2663:
2658:
2653:
2648:
2643:
2637:
2635:
2631:
2630:
2625:
2623:
2622:
2615:
2608:
2600:
2591:
2590:
2588:
2587:
2586:
2585:
2580:
2570:
2565:
2556:
2542:
2537:
2532:
2531:
2530:
2525:
2515:
2510:
2505:
2499:
2497:
2493:
2492:
2490:
2489:
2484:
2478:
2476:
2470:
2469:
2467:
2466:
2461:
2456:
2451:
2445:
2443:
2436:
2435:
2433:
2432:
2427:
2426:
2425:
2420:
2410:
2405:
2400:
2394:
2392:
2386:
2385:
2383:
2382:
2381:
2380:
2375:
2365:
2353:
2352:
2351:
2350:
2345:
2340:
2335:
2330:
2325:
2320:
2315:
2310:
2305:
2300:
2295:
2290:
2285:
2280:
2275:
2265:
2260:
2255:
2250:
2245:
2240:
2231:
2229:
2223:
2222:
2220:
2219:
2218:
2217:
2212:
2202:
2197:
2192:
2186:
2184:
2178:
2177:
2162:Endopeptidases
2160:
2158:
2157:
2150:
2143:
2135:
2126:
2125:
2123:
2122:
2116:
2109:
2106:
2103:
2102:
2099:
2097:
2096:
2089:
2082:
2074:
2052:
2051:
2030:
2023:
2022:External links
2020:
2018:
2017:
1988:
1945:
1910:
1881:
1836:
1801:
1764:
1735:
1706:
1686:(13): 6055–9.
1671:
1626:
1606:(4): 2575–81.
1592:
1555:
1531:Clin. Lab. Med
1526:
1489:
1459:
1457:
1454:
1451:
1450:
1406:
1365:
1324:
1275:
1240:
1226:
1208:
1190:
1169:
1147:
1146:
1144:
1141:
1140:
1139:
1132:
1129:
1123:
1120:
1104:carboxyl group
1091:
1088:
1048:
1047:
1044:
1043:
1038:
1028:
1027:
1021:
1020:
1017:
1016:
1014:
1012:
1005:
1004:
997:
990:
986:
985:
982:
981:
971:
970:
964:
961:
960:
950:
949:
943:
939:
938:
935:
934:
924:
923:
917:
914:
913:
903:
902:
896:
892:
891:
888:
887:
879:
878:
872:
869:
868:
860:
859:
853:
847:
846:
843:
842:
834:
833:
827:
824:
823:
811:
810:
804:
798:
797:
794:
793:
785:
784:
778:
775:
774:
766:
765:
759:
753:
752:
747:
742:
738:
737:
727:
726:
723:
722:
711:
710:
708:
707:
702:
697:
692:
686:
684:
680:
679:
677:
676:
671:
666:
661:
656:
650:
648:
644:
643:
641:
640:
635:
630:
625:
620:
614:
612:
608:
607:
597:
596:
593:
592:
589:
588:
580:
579:
568:
562:
561:
558:
557:
549:
548:
545:
544:
542:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
498:
497:
486:
483:
482:
480:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
436:
435:
423:
422:
414:
403:
397:
396:
393:RNA expression
385:
384:
381:
380:
372:
368:
367:
359:
356:
351:
345:
344:
335:
328:
322:
318:
317:
312:
306:
305:
297:
296:
284:
283:
280:
279:
271:
267:
266:
258:
255:
250:
244:
243:
234:
227:
221:
217:
216:
209:
203:
202:
194:
193:
181:
180:
137:
133:
132:
124:
116:
115:
111:
110:
107:
106:
103:
102:
76:
75:
67:
66:
55:
49:
48:
40:
39:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
3005:
2994:
2991:
2989:
2986:
2984:
2981:
2980:
2978:
2967:
2962:
2960:
2955:
2953:
2948:
2947:
2941:
2939:
2935:
2931:
2927:
2922:
2919:
2915:
2910:
2904:
2899:
2894:
2890:
2876:
2872:
2871:
2866:
2863:
2859:
2858:
2853:
2850:
2846:
2845:
2840:
2837:
2833:
2832:
2827:
2824:
2820:
2819:
2814:
2811:
2807:
2806:
2801:
2798:
2794:
2793:
2788:
2787:
2785:
2781:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2751:
2749:
2745:
2739:
2736:
2734:
2733:Enzyme family
2731:
2729:
2726:
2724:
2721:
2720:
2718:
2714:
2708:
2705:
2703:
2700:
2698:
2697:Cooperativity
2695:
2693:
2690:
2689:
2687:
2683:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2656:Oxyanion hole
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2638:
2636:
2632:
2628:
2621:
2616:
2614:
2609:
2607:
2602:
2601:
2598:
2584:
2581:
2579:
2576:
2575:
2574:
2571:
2569:
2568:Streptokinase
2566:
2564:
2560:
2557:
2554:
2550:
2546:
2543:
2541:
2538:
2536:
2533:
2529:
2526:
2524:
2521:
2520:
2519:
2516:
2514:
2511:
2509:
2506:
2504:
2501:
2500:
2498:
2494:
2488:
2485:
2483:
2480:
2479:
2477:
2475:
2471:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2446:
2444:
2442:
2441:immune system
2437:
2431:
2430:C3-convertase
2428:
2424:
2421:
2419:
2416:
2415:
2414:
2411:
2409:
2406:
2404:
2401:
2399:
2396:
2395:
2393:
2391:
2387:
2379:
2376:
2374:
2371:
2370:
2369:
2366:
2364:
2361:
2359:
2355:
2354:
2349:
2346:
2344:
2341:
2339:
2336:
2334:
2331:
2329:
2326:
2324:
2321:
2319:
2316:
2314:
2311:
2309:
2306:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2279:
2276:
2274:
2271:
2270:
2269:
2266:
2264:
2261:
2259:
2256:
2254:
2251:
2249:
2246:
2244:
2241:
2239:
2236:
2233:
2232:
2230:
2228:
2224:
2216:
2213:
2211:
2208:
2207:
2206:
2203:
2201:
2198:
2196:
2193:
2191:
2188:
2187:
2185:
2183:
2179:
2174:
2171:
2167:
2163:
2156:
2151:
2149:
2144:
2142:
2137:
2136:
2133:
2119:
2113:
2108:
2104:
2095:
2090:
2088:
2083:
2081:
2076:
2075:
2072:
2068:
2065:
2064:
2062:
2061:public domain
2058:
2049:
2045:
2044:
2039:
2035:
2031:
2029:
2026:
2025:
2021:
2014:
2010:
2006:
2002:
1998:
1994:
1989:
1985:
1981:
1976:
1971:
1967:
1963:
1959:
1955:
1951:
1946:
1942:
1938:
1933:
1928:
1924:
1920:
1919:J. Biol. Chem
1916:
1911:
1907:
1903:
1899:
1895:
1891:
1887:
1882:
1878:
1874:
1870:
1866:
1862:
1858:
1854:
1850:
1846:
1842:
1837:
1833:
1829:
1824:
1819:
1815:
1811:
1810:J. Biol. Chem
1807:
1802:
1798:
1794:
1790:
1786:
1782:
1778:
1775:(4): 369–76.
1774:
1770:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1736:
1732:
1728:
1724:
1720:
1716:
1712:
1707:
1703:
1699:
1694:
1689:
1685:
1681:
1680:J. Biol. Chem
1677:
1672:
1668:
1664:
1659:
1654:
1649:
1644:
1640:
1636:
1632:
1627:
1623:
1619:
1614:
1609:
1605:
1601:
1600:J. Biol. Chem
1598:
1593:
1589:
1585:
1581:
1577:
1573:
1569:
1566:(3): 248–53.
1565:
1561:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1500:(3): 245–52.
1499:
1495:
1490:
1486:
1482:
1478:
1474:
1470:
1466:
1461:
1460:
1455:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1410:
1407:
1402:
1398:
1393:
1388:
1385:(4): 1063–8.
1384:
1380:
1376:
1369:
1366:
1361:
1357:
1352:
1347:
1343:
1339:
1335:
1328:
1325:
1320:
1316:
1312:
1308:
1303:
1298:
1294:
1290:
1286:
1279:
1276:
1271:
1267:
1263:
1259:
1255:
1251:
1244:
1241:
1236:
1230:
1227:
1222:
1218:
1212:
1209:
1204:
1200:
1194:
1191:
1187:
1183:
1178:
1176:
1174:
1170:
1166:
1162:
1157:
1155:
1153:
1149:
1142:
1138:
1135:
1134:
1130:
1128:
1121:
1119:
1117:
1113:
1109:
1105:
1101:
1097:
1089:
1087:
1085:
1081:
1077:
1073:
1069:
1066:
1062:
1058:
1054:
1042:
1037:
1033:
1029:
1026:
1022:
1015:
1013:
1010:
1006:
1002:
998:
995:
991:
987:
980:
978:
972:
968:
965:
959:
957:
951:
947:
944:
940:
933:
931:
925:
921:
918:
912:
910:
904:
900:
897:
895:RefSeq (mRNA)
893:
886:
885:
880:
876:
873:
867:
866:
861:
857:
854:
852:
848:
841:
840:
835:
831:
828:
822:
821:
817:
812:
808:
805:
803:
799:
792:
791:
786:
782:
779:
773:
772:
767:
763:
760:
758:
754:
751:
748:
746:
743:
739:
736:
732:
728:
721:
717:
712:
706:
703:
701:
698:
696:
693:
691:
688:
687:
685:
682:
681:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
651:
649:
646:
645:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
615:
613:
610:
609:
606:
605:Gene ontology
602:
598:
586:
581:
577:
572:
569:
567:
563:
555:
550:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
502:
499:
495:
490:
487:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
440:
437:
433:
428:
425:
424:
421:
419:
415:
413:
412:
408:
407:
404:
402:
398:
394:
390:
386:
378:
373:
369:
365:
360:
350:
346:
339:
332:
326:
319:
311:
307:
303:
298:
294:
289:
285:
277:
272:
268:
264:
259:
249:
245:
238:
231:
225:
218:
214:
208:
204:
200:
195:
191:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
134:
129:
122:
117:
112:
101:
99:
95:
91:
87:
83:
77:
72:
69:
68:
64:
61:
54:
50:
45:
41:
37:
32:
27:
22:
2938:expanding it
2930:chromosome 7
2923:
2908:
2870:Translocases
2867:
2854:
2841:
2828:
2815:
2805:Transferases
2802:
2789:
2646:Binding site
2358:fibrinolysis
2356:
2234:
2200:Chymotrypsin
2117:
2066:
2054:
2053:
2041:
1996:
1993:Biochemistry
1992:
1957:
1953:
1922:
1918:
1889:
1886:J. Mol. Biol
1885:
1844:
1840:
1813:
1809:
1772:
1768:
1743:
1739:
1717:(1): 31–46.
1714:
1710:
1683:
1679:
1638:
1634:
1603:
1599:
1563:
1559:
1537:(1): 39–59.
1534:
1530:
1497:
1493:
1471:(3): 463–9.
1468:
1464:
1423:(2): 141–5.
1420:
1416:
1409:
1382:
1378:
1368:
1344:(7): 473–9.
1341:
1337:
1327:
1295:(1): 39–43.
1292:
1288:
1278:
1253:
1249:
1243:
1229:
1220:
1211:
1202:
1193:
1125:
1116:pancreatitis
1093:
1064:
1056:
1052:
1051:
977:NP_001034085
974:
953:
930:NM_001038996
927:
906:
882:
863:
837:
814:
788:
769:
749:
744:
416:
409:
274:142,753,076
261:142,749,468
136:External IDs
79:
2641:Active site
2263:Factor XIIa
2243:Factor VIIa
2227:Coagulation
2100:PDB gallery
1256:(1): 8–15.
1076:trypsinogen
705:proteolysis
516:granulocyte
375:41,334,848
362:41,331,039
354:6|6 B1
114:Identifiers
2977:Categories
2844:Isomerases
2818:Hydrolases
2685:Regulation
2545:Subtilisin
2487:Batroxobin
2268:Kallikrein
2258:Factor XIa
2248:Factor IXa
2215:Pancreatic
2210:Neutrophil
1954:Biochem. J
1494:Hum. Genet
1289:Hum. Mutat
1188:, May 2017
1167:, May 2017
1143:References
1098:family of
462:ectocervix
420:(ortholog)
157:HomoloGene
2988:EC 3.4.21
2928:on human
2723:EC number
2573:Cathepsin
2559:Sedolisin
2535:Prostasin
2253:Factor Xa
1084:trypsin-3
1080:trypsin-2
1053:Trypsin-1
956:NP_002760
909:NM_002769
735:Orthologs
690:digestion
528:esophagus
165:GeneCards
2747:Kinetics
2671:Cofactor
2634:Activity
2474:Venombin
2459:Tryptase
2454:Granzyme
2408:Factor I
2403:Factor D
2398:Factor B
2238:Thrombin
2235:factors:
2205:Elastase
1877:84766616
1797:40599814
1588:23606613
1580:16764792
1551:15749231
1522:24099557
1514:11702203
1485:11073713
1445:21974705
1360:10909845
1319:45885044
1270:21907651
1184:–
1163:–
1131:See also
1112:arginine
1090:Function
1025:Wikidata
714:Sources:
524:duodenum
504:pancreas
470:testicle
450:duodenum
2903:Biology
2857:Ligases
2627:Enzymes
2513:Pronase
2503:Acrosin
2449:Chymase
2363:Plasmin
2195:Trypsin
2048:PDBe-KB
2038:UniProt
2013:9402754
1984:9169621
1975:1218391
1941:8910369
1906:8683601
1869:8650574
1849:Bibcode
1841:Science
1832:8340386
1789:6589790
1760:3011602
1731:2598466
1702:2437112
1667:1763044
1622:1370825
1437:8841182
1401:9322498
1311:9633818
1186:Ensembl
1165:Ensembl
1137:Trypsin
1096:trypsin
1072:isoform
1061:protein
1059:, is a
851:UniProt
802:Ensembl
741:Species
720:QuickGO
532:jejunum
512:stomach
395:pattern
153:3687012
121:Aliases
2889:Portal
2831:Lyases
2540:Reelin
2482:Ancrod
2439:Other
2173:3.4.21
2043:P07477
2011:
1982:
1972:
1939:
1904:
1875:
1867:
1830:
1795:
1787:
1758:
1729:
1700:
1665:
1655:
1620:
1586:
1578:
1549:
1520:
1512:
1483:
1443:
1435:
1399:
1358:
1317:
1309:
1268:
1108:lysine
1011:search
1009:PubMed
884:Q792Z1
865:P07477
790:436522
757:Entrez
566:BioGPS
458:fundus
161:134623
145:276000
2932:is a
2783:Types
2549:Furin
2496:Other
2423:MASP2
2418:MASP1
2348:KLK15
2343:KLK14
2338:KLK13
2333:KLK12
2328:KLK11
2323:KLK10
1873:S2CID
1793:S2CID
1658:53126
1584:S2CID
1518:S2CID
1441:S2CID
1315:S2CID
1065:PRSS1
750:Mouse
745:Human
716:Amigo
540:liver
520:colon
418:Mouse
411:Human
358:Start
293:Mouse
257:Start
190:Human
169:PRSS1
128:PRSS1
29:PRSS1
2934:stub
2926:gene
2875:list
2868:EC7
2862:list
2855:EC6
2849:list
2842:EC5
2836:list
2829:EC4
2823:list
2816:EC3
2810:list
2803:EC2
2797:list
2790:EC1
2563:TPP1
2413:MASP
2318:KLK9
2313:KLK8
2308:KLK7
2303:KLK6
2298:KLK5
2293:KLK4
2288:KLK3
2283:KLK2
2278:KLK1
2118:1trn
2036:for
2009:PMID
1980:PMID
1937:PMID
1902:PMID
1865:PMID
1828:PMID
1785:PMID
1756:PMID
1740:Gene
1727:PMID
1698:PMID
1663:PMID
1618:PMID
1576:PMID
1547:PMID
1510:PMID
1481:PMID
1433:PMID
1397:PMID
1356:PMID
1307:PMID
1266:PMID
1068:gene
771:5644
401:Bgee
349:Band
310:Chr.
253:7q34
248:Band
207:Chr.
141:OMIM
98:4WXV
94:4WWY
90:2RA3
86:1TRN
82:1FXY
63:RCSB
60:PDBe
2553:S1P
2273:PSA
2034:PDB
2001:doi
1970:PMC
1962:doi
1958:323
1927:doi
1923:271
1894:doi
1890:259
1857:doi
1845:272
1818:doi
1814:268
1777:doi
1748:doi
1719:doi
1715:184
1688:doi
1684:262
1653:PMC
1643:doi
1608:doi
1604:267
1568:doi
1539:doi
1502:doi
1498:109
1473:doi
1425:doi
1387:doi
1383:113
1346:doi
1297:doi
1258:doi
1110:or
1106:of
1074:of
371:End
270:End
173:OMA
149:MGI
53:PDB
2979::
2170:EC
2164::
2040::
2007:.
1997:36
1995:.
1978:.
1968:.
1956:.
1952:.
1935:.
1921:.
1917:.
1900:.
1888:.
1871:.
1863:.
1855:.
1843:.
1826:.
1812:.
1808:.
1791:.
1783:.
1773:10
1771:.
1754:.
1744:41
1742:.
1725:.
1713:.
1696:.
1682:.
1678:.
1661:.
1651:.
1639:88
1637:.
1633:.
1616:.
1602:.
1582:.
1574:.
1562:.
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