181:
206:
414:
2658:
212:
42:
1333:
Imielinski M, Berger AG, Hammerman PS, Hernandez B, Pugh TJ, Hodis E, Cho J, Suh J, Capelletti M, Sivachenko A, Sougnez C, Auclair A, Lawrence MS, Stojanov P, Cibulskis K, Choi K, de Waal L, Sharifnia T, Brooks A, Greulich H, Banerji S, Zander T, Seidel D, Leenders F, Ansén S, Ludwig C, Engel-Riedel
1659:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
68:
1145:
Lalioti MD, Gos A, Green MR, Rossier C, Morris MA, Antonarakis SE (January 1997). "The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3".
1660:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
2248:
Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex".
1181:
Kalcheva I, Plass C, Sait S, Eddy R, Shows T, Watkins-Chow D, Camper S, Shibata H, Ueda T, Takagi N (Dec 1994). "Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5".
1334:
W, Stoelben E, Wolf J, Goparju C, Thompson K, Winckler W, Kwiatkowski D, Johnson BE, Jänne PA, Miller VA, Pao W, Travis WD, Pass HI, Gabriel SB, Lander ES, Thomas RK, Garraway LA, Getz G, et al. (2012).
1583:
Maita H, Kitaura H, Keen TJ, Inglehearn CF, Ariga H, Iguchi-Ariga SM (November 2004). "PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor".
1003:
branch site. This gene encodes a small (~35 kDa) subunit which plays a critical role in RNA splicing by recognizing and binding to AG nucleotides at the 3’ splice site to facilitate
219:
2088:"SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells"
2536:
Esfahani MS, Lee LJ, Jeon YJ, Flynn R, Stehr H, Hui A, Ishisoko N, Kildebeck E, Newman AM, Bratman SV, Porteus MH, Chang HY, Alizadeh AA, Diehn M (2019).
142:
1027:
implicating a functional role under selection. In lung cancers, these mutations affect alternative splicing of several transcripts, including oncogenic
648:
2495:"Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation"
1620:"Splicing factor SPF30 bridges an interaction between the prespliceosome protein U2AF35 and tri-small nuclear ribonucleoprotein protein hPrp3"
2686:
2637:
2657:
1127:
1920:
Wu JY, Maniatis T (1994). "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing".
1879:"Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution"
2172:
Lallena MJ, Martínez C, Valcárcel J, Correas I (1998). "Functional association of nuclear protein 4.1 with pre-mRNA splicing factors".
905:
1217:
1114:
1282:
Wu S, Romfo CM, Nilsen TW, Green MR (1999). "Functional recognition of the 3' splice site AG by the splicing factor U2AF35".
205:
180:
1959:"The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing"
65:
1110:
1031:
fusions. U2af1 conditional deletion in mouse hematopoietic system leads to early lethality suggesting its important for
130:
1233:"Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor"
1048:
218:
211:
2630:
2331:"Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors"
1826:"Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit"
1713:"Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit"
2037:"A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA"
1032:
691:
194:
2623:
2549:
2048:
1837:
1724:
1669:
1398:
1291:
1244:
1008:
117:
988:
family of genes . U2AF1 is a subunit of the U2 Auxiliary Factor complex alongside a larger subunit,
2450:
Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC (2001).
993:
865:
861:
853:
843:
839:
835:
831:
827:
784:
780:
1495:"Functional properties of p54, a novel SR protein active in constitutive and alternative splicing"
1023:
have been found in a range of human cancers, with a distinctive pattern of these mutations at the
2274:
2074:
1945:
1693:
1315:
154:
2288:"Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2"
1446:"Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2"
869:
857:
788:
2595:
2575:
2524:
2481:
2438:
2395:
2360:
2317:
2266:
2236:
2189:
2160:
2117:
2066:
2023:
1980:
1937:
1908:
1865:
1801:
1752:
1685:
1641:
1600:
1565:
1524:
1475:
1426:
1367:
1307:
1272:
1199:
1163:
110:
58:
2565:
2557:
2514:
2506:
2471:
2463:
2428:
2420:
2385:
2350:
2342:
2307:
2299:
2258:
2226:
2218:
2202:
2181:
2150:
2142:
2107:
2099:
2056:
2013:
2005:
1970:
1929:
1898:
1890:
1855:
1845:
1791:
1783:
1742:
1732:
1677:
1631:
1592:
1555:
1514:
1506:
1465:
1457:
1416:
1406:
1357:
1347:
1299:
1262:
1252:
1191:
1155:
1016:
1012:
298:
229:
413:
150:
2207:"A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site"
273:
2131:"Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo"
2553:
2052:
1841:
1728:
1673:
1402:
1295:
1248:
2570:
2537:
2433:
2408:
2312:
2287:
2112:
2087:
1894:
1796:
1771:
1470:
1445:
1421:
1386:
1362:
1335:
41:
2476:
2451:
2355:
2330:
2231:
2206:
2155:
2130:
2018:
1993:
1903:
1878:
1519:
1494:
1385:
Esfahani MS, Lee LJ, Jeon YJ, Flynn RA, Stehr H, Hui AB, et al. (December 2019).
1267:
1232:
582:
577:
572:
567:
562:
557:
552:
547:
542:
526:
521:
516:
511:
506:
501:
496:
480:
475:
470:
465:
460:
455:
2680:
2604:
2519:
2510:
2494:
1933:
1860:
1825:
1747:
1712:
442:
2452:"A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site"
1949:
2078:
1697:
1319:
291:
171:
2278:
2372:
Gama-Carvalho M, Carvalho MP, Kehlenbach A, Valcarcel J, Carmo-Fonseca M (2001).
1336:"Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing"
158:
1770:
Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (July 2001).
1596:
1132:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1024:
1004:
2561:
2467:
2346:
2303:
1461:
1411:
1352:
985:
188:
138:
1036:
2329:
de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W (2000).
2185:
1850:
1737:
1257:
612:
391:
312:
257:
244:
146:
2579:
2528:
2485:
2442:
2407:
Adams DJ, van der Weyden L, Mayeda A, Stamm S, Morris BJ, Rasko JE (2001).
2399:
2390:
2373:
2364:
2086:
Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (1998).
2009:
1975:
1958:
1805:
1711:
Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR (September 1992).
1689:
1645:
1636:
1619:
1604:
1569:
1560:
1543:
1510:
1430:
1371:
1311:
1159:
2424:
2409:"ZNF265--a novel spliceosomal protein able to induce alternative splicing"
2321:
2270:
2240:
2222:
2193:
2164:
2146:
2121:
2103:
2070:
2027:
1984:
1941:
1912:
1869:
1787:
1772:"ZNF265--a novel spliceosomal protein able to induce alternative splicing"
1756:
1528:
1479:
1276:
1203:
1167:
948:
2538:"Functional significance of U2AF1 S34F mutations in lung adenocarcinomas"
1387:"Functional significance of U2AF1 S34F mutations in lung adenocarcinomas"
1000:
937:
738:
734:
1681:
2609:
2599:
1542:
Zolotukhin AS, Tan W, Bear J, Smulevitch S, Felber BK (February 2002).
1055:
966:
720:
677:
1195:
121:, FP793, RN, RNU2AF35, U2AFBP, U2 small nuclear RNA auxiliary factor 1
87:
1085:
1073:
918:
634:
17:
2374:"Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF"
2061:
2036:
1303:
1079:
996:
989:
2262:
1992:
Hong W, Bennett M, Xiao Y, Feld Kramer R, Wang C, Reed R (1997).
1824:
Zhang M, Zamore PD, Carmo-Fonseca M, Lamond AI, Green MR (1992).
597:
593:
1061:
1028:
973:
134:
2619:
422:
2615:
1067:
2594:
Overview of all the structural information available in the
1218:"Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1"
992:. U2AF1 is a non-snRNP protein required for the binding of
1047:
U2 small nuclear RNA auxiliary factor 1 has been shown to
1994:"Association of U2 snRNP with the spliceosomal complex E"
548:
positive regulation of protein targeting to mitochondrion
1544:"U2AF participates in the binding of TAP (NXF1) to mRNA"
281:
2666:: X-ray Structure of a Core U2AF65/U2AF35 Heterodimer
403:
883:
826:
802:
773:
1106:
1104:
1102:
228:
2129:Rudner DZ, Kanaar R, Breger KS, Rio DC (1998).
29:Protein-coding gene in the species Homo sapiens
543:termination of RNA polymerase II transcription
2631:
2608:(Splicing factor U2AF 35 kDa subunit) at the
8:
1111:GRCh38: Ensembl release 89: ENSG00000160201
2638:
2624:
2616:
1037:https://doi.org/10.1038/s41375-020-01116-x
823:
608:
438:
269:
166:
76:
2569:
2518:
2475:
2432:
2389:
2354:
2311:
2230:
2154:
2111:
2060:
2017:
1974:
1902:
1859:
1849:
1795:
1746:
1736:
1635:
1559:
1518:
1469:
1420:
1410:
1361:
1351:
1266:
1256:
984:This gene belongs to the splicing factor
563:regulation of autophagy of mitochondrion
2653:
1098:
1011:transcript variants encoding different
31:
233:
192:
187:
7:
1444:Xiao SH, Manley JL (November 1998).
2035:Tronchère H, Wang J, Fu XD (1997).
1618:Little JT, Jurica MS (March 2008).
963:Splicing factor U2AF 35 kDa subunit
1895:10.1002/j.1460-2075.1991.tb07937.x
880:
799:
770:
748:
725:
701:
682:
658:
639:
408:
369:
307:
286:
25:
969:that in humans is encoded by the
2656:
2511:10.1128/MCB.21.19.6406-6417.2001
1493:Zhang WJ, Wu JY (October 1996).
412:
217:
210:
204:
179:
40:
471:pre-mRNA 3'-splice site binding
583:mRNA splicing, via spliceosome
423:More reference expression data
392:More reference expression data
335:olfactory zone of nasal mucosa
1:
202:
2687:Genes on human chromosome 21
1934:10.1016/0092-8674(93)90316-I
1877:Zamore PD, Green MR (1991).
1830:Proc. Natl. Acad. Sci. U.S.A
1717:Proc. Natl. Acad. Sci. U.S.A
1231:Zamore PD, Green MR (1989).
507:catalytic step 2 spliceosome
2286:Xiao SH, Manley JL (1999).
1597:10.1016/j.yexcr.2004.07.029
347:stromal cell of endometrium
2703:
2562:10.1038/s41467-019-13392-y
2493:Nesic D, Krämer A (2001).
1957:Zuo P, Maniatis T (1996).
1412:10.1038/s41467-019-13392-y
1353:10.1016/j.cell.2012.08.029
1035:maintenance and function {
339:mucosa of transverse colon
2651:
1128:"Human PubMed Reference:"
952:
947:
943:
936:
917:
900:
887:
850:
819:
806:
777:
766:
755:
751:
732:
728:
719:
708:
704:
689:
685:
676:
665:
661:
646:
642:
633:
618:
611:
607:
591:
441:
437:
420:
411:
402:
389:
376:
372:
319:
310:
280:
272:
268:
251:
238:
201:
178:
169:
165:
128:
125:
115:
108:
103:
84:
79:
62:
57:
52:
48:
39:
34:
2468:10.1093/emboj/20.16.4536
2347:10.1093/emboj/19.21.5895
2304:10.1093/emboj/17.21.6359
1462:10.1093/emboj/17.21.6359
906:Chr 21: 43.09 – 43.11 Mb
558:mRNA export from nucleus
2186:10.1242/jcs.111.14.1963
1851:10.1073/pnas.89.18.8769
1738:10.1073/pnas.89.18.8769
1258:10.1073/pnas.86.23.9243
1033:hematopoietic stem cell
1015:have been identified .
578:RNA export from nucleus
2391:10.1074/jbc.M008759200
1976:10.1101/gad.10.11.1356
1637:10.1074/jbc.M707984200
1561:10.1074/jbc.M107598200
1511:10.1128/MCB.16.10.5400
1160:10.1006/geno.1996.0196
573:mRNA 3'-end processing
63:Human UniProt search:
2542:Nature Communications
2425:10.1083/jcb.200010059
2223:10.1128/mcb.18.8.4752
2147:10.1128/MCB.18.4.1765
2104:10.1083/jcb.140.4.737
1788:10.1083/jcb.200010059
1391:Nature Communications
1009:Alternatively spliced
195:Chromosome 21 (human)
2010:10.1093/nar/25.2.354
1184:Cytogenet Cell Genet
522:spliceosomal complex
466:nucleic acid binding
80:List of PDB id codes
53:Available structures
2554:2019NatCo..10.5712E
2384:(16): 13104–13112.
2053:1997Natur.388..397T
1842:1992PNAS...89.8769Z
1729:1992PNAS...89.8769Z
1682:10.1038/nature04209
1674:2005Natur.437.1173R
1403:2019NatCo..10.5712E
1296:1999Natur.402..832W
1249:1989PNAS...86.9243Z
536:Biological process
490:Cellular component
449:Molecular function
323:anterior pituitary
2674:
2673:
2505:(19): 6406–6417.
2462:(16): 4536–4546.
2341:(21): 5895–5904.
2298:(21): 6359–6367.
2205:, Reed R (1998).
2047:(6640): 397–400.
1998:Nucleic Acids Res
1969:(11): 1356–1368.
1836:(18): 8769–8773.
1243:(23): 9243–9247.
1196:10.1159/000133881
1017:Somatic mutations
960:
959:
956:
955:
932:
931:
896:
895:
877:
876:
815:
814:
796:
795:
762:
761:
745:
744:
715:
714:
698:
697:
672:
671:
655:
654:
603:
602:
481:RS domain binding
456:metal ion binding
433:
432:
429:
428:
398:
397:
385:
384:
366:
365:
327:left uterine tube
264:
263:
159:U2AF1 - orthologs
99:
98:
95:
94:
16:(Redirected from
2694:
2660:
2640:
2633:
2626:
2617:
2583:
2573:
2532:
2522:
2489:
2479:
2446:
2436:
2403:
2393:
2368:
2358:
2325:
2315:
2282:
2244:
2234:
2197:
2168:
2158:
2125:
2115:
2082:
2064:
2031:
2021:
1988:
1978:
1953:
1928:(6): 1061–1070.
1916:
1906:
1873:
1863:
1853:
1810:
1809:
1799:
1767:
1761:
1760:
1750:
1740:
1708:
1702:
1701:
1668:(7062): 1173–8.
1656:
1650:
1649:
1639:
1615:
1609:
1608:
1580:
1574:
1573:
1563:
1539:
1533:
1532:
1522:
1490:
1484:
1483:
1473:
1441:
1435:
1434:
1424:
1414:
1382:
1376:
1375:
1365:
1355:
1346:(6): 1107–1120.
1330:
1324:
1323:
1280:
1270:
1260:
1228:
1222:
1221:
1214:
1208:
1207:
1178:
1172:
1171:
1142:
1136:
1135:
1124:
1118:
1108:
945:
944:
928:
913:
908:
891:
881:
872:
824:
820:RefSeq (protein)
810:
800:
791:
771:
749:
726:
702:
683:
659:
640:
609:
439:
425:
416:
409:
394:
370:
315:
313:Top expressed in
308:
287:
270:
260:
247:
236:
221:
214:
208:
197:
183:
167:
161:
120:
113:
90:
77:
71:
50:
49:
44:
32:
21:
2702:
2701:
2697:
2696:
2695:
2693:
2692:
2691:
2677:
2676:
2675:
2670:
2667:
2661:
2647:
2644:
2591:
2586:
2535:
2499:Mol. Cell. Biol
2492:
2449:
2406:
2371:
2328:
2285:
2247:
2211:Mol. Cell. Biol
2200:
2180:(14): 1963–71.
2171:
2135:Mol. Cell. Biol
2128:
2085:
2034:
1991:
1956:
1919:
1876:
1823:
1819:
1817:Further reading
1814:
1813:
1769:
1768:
1764:
1723:(18): 8769–73.
1710:
1709:
1705:
1658:
1657:
1653:
1630:(13): 8145–52.
1617:
1616:
1612:
1582:
1581:
1577:
1541:
1540:
1536:
1499:Mol. Cell. Biol
1492:
1491:
1487:
1456:(21): 6359–67.
1443:
1442:
1438:
1384:
1383:
1379:
1332:
1331:
1327:
1290:(6763): 832–5.
1281:
1230:
1229:
1225:
1216:
1215:
1211:
1180:
1179:
1175:
1144:
1143:
1139:
1126:
1125:
1121:
1109:
1100:
1095:
1045:
982:
949:View/Edit Human
926:
911:
904:
901:Location (UCSC)
889:
868:
864:
860:
856:
852:
846:
842:
838:
834:
830:
808:
787:
783:
779:
737:
692:ENSG00000160201
587:
553:mRNA processing
531:
485:
461:protein binding
421:
390:
381:
362:
357:
353:
349:
345:
341:
337:
333:
329:
325:
311:
255:
242:
234:
224:
223:
222:
215:
193:
170:Gene location (
129:
116:
109:
86:
64:
30:
23:
22:
15:
12:
11:
5:
2700:
2698:
2690:
2689:
2679:
2678:
2672:
2671:
2669:
2668:
2662:
2655:
2652:
2649:
2648:
2645:
2643:
2642:
2635:
2628:
2620:
2614:
2613:
2590:
2589:External links
2587:
2585:
2584:
2533:
2490:
2447:
2404:
2369:
2326:
2283:
2245:
2217:(8): 4752–60.
2198:
2169:
2141:(4): 1765–73.
2126:
2098:(4): 737–750.
2083:
2032:
2004:(2): 354–361.
1989:
1954:
1917:
1874:
1820:
1818:
1815:
1812:
1811:
1762:
1703:
1651:
1610:
1575:
1554:(6): 3935–42.
1534:
1505:(10): 5400–8.
1485:
1436:
1377:
1325:
1223:
1209:
1190:(1–2): 19–24.
1173:
1154:(2): 298–300.
1137:
1119:
1097:
1096:
1094:
1091:
1090:
1089:
1083:
1077:
1071:
1065:
1059:
1044:
1041:
981:
978:
958:
957:
954:
953:
951:
941:
940:
934:
933:
930:
929:
924:
922:
915:
914:
909:
902:
898:
897:
894:
893:
885:
884:
878:
875:
874:
848:
847:
821:
817:
816:
813:
812:
804:
803:
797:
794:
793:
775:
774:
768:
764:
763:
760:
759:
753:
752:
746:
743:
742:
730:
729:
723:
717:
716:
713:
712:
706:
705:
699:
696:
695:
687:
686:
680:
674:
673:
670:
669:
663:
662:
656:
653:
652:
644:
643:
637:
631:
630:
625:
620:
616:
615:
605:
604:
601:
600:
589:
588:
586:
585:
580:
575:
570:
565:
560:
555:
550:
545:
539:
537:
533:
532:
530:
529:
524:
519:
514:
509:
504:
499:
493:
491:
487:
486:
484:
483:
478:
473:
468:
463:
458:
452:
450:
446:
445:
435:
434:
431:
430:
427:
426:
418:
417:
406:
400:
399:
396:
395:
387:
386:
383:
382:
380:
377:
374:
373:
367:
364:
363:
361:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
317:
316:
304:
303:
295:
284:
278:
277:
274:RNA expression
266:
265:
262:
261:
253:
249:
248:
240:
237:
232:
226:
225:
216:
209:
203:
199:
198:
191:
185:
184:
176:
175:
163:
162:
127:
123:
122:
114:
106:
105:
101:
100:
97:
96:
93:
92:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2699:
2688:
2685:
2684:
2682:
2665:
2659:
2654:
2650:
2641:
2636:
2634:
2629:
2627:
2622:
2621:
2618:
2611:
2607:
2606:
2601:
2597:
2593:
2592:
2588:
2581:
2577:
2572:
2567:
2563:
2559:
2555:
2551:
2547:
2543:
2539:
2534:
2530:
2526:
2521:
2516:
2512:
2508:
2504:
2500:
2496:
2491:
2487:
2483:
2478:
2473:
2469:
2465:
2461:
2457:
2453:
2448:
2444:
2440:
2435:
2430:
2426:
2422:
2418:
2414:
2410:
2405:
2401:
2397:
2392:
2387:
2383:
2379:
2378:J. Biol. Chem
2375:
2370:
2366:
2362:
2357:
2352:
2348:
2344:
2340:
2336:
2332:
2327:
2323:
2319:
2314:
2309:
2305:
2301:
2297:
2293:
2289:
2284:
2280:
2276:
2272:
2268:
2264:
2260:
2256:
2252:
2246:
2242:
2238:
2233:
2228:
2224:
2220:
2216:
2212:
2208:
2204:
2199:
2195:
2191:
2187:
2183:
2179:
2175:
2170:
2166:
2162:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2127:
2123:
2119:
2114:
2109:
2105:
2101:
2097:
2093:
2089:
2084:
2080:
2076:
2072:
2068:
2063:
2062:10.1038/41137
2058:
2054:
2050:
2046:
2042:
2038:
2033:
2029:
2025:
2020:
2015:
2011:
2007:
2003:
1999:
1995:
1990:
1986:
1982:
1977:
1972:
1968:
1964:
1960:
1955:
1951:
1947:
1943:
1939:
1935:
1931:
1927:
1923:
1918:
1914:
1910:
1905:
1900:
1896:
1892:
1889:(1): 207–14.
1888:
1884:
1880:
1875:
1871:
1867:
1862:
1857:
1852:
1847:
1843:
1839:
1835:
1831:
1827:
1822:
1821:
1816:
1807:
1803:
1798:
1793:
1789:
1785:
1781:
1777:
1773:
1766:
1763:
1758:
1754:
1749:
1744:
1739:
1734:
1730:
1726:
1722:
1718:
1714:
1707:
1704:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1667:
1663:
1655:
1652:
1647:
1643:
1638:
1633:
1629:
1625:
1624:J. Biol. Chem
1621:
1614:
1611:
1606:
1602:
1598:
1594:
1591:(2): 283–96.
1590:
1586:
1585:Exp. Cell Res
1579:
1576:
1571:
1567:
1562:
1557:
1553:
1549:
1548:J. Biol. Chem
1545:
1538:
1535:
1530:
1526:
1521:
1516:
1512:
1508:
1504:
1500:
1496:
1489:
1486:
1481:
1477:
1472:
1467:
1463:
1459:
1455:
1451:
1447:
1440:
1437:
1432:
1428:
1423:
1418:
1413:
1408:
1404:
1400:
1396:
1392:
1388:
1381:
1378:
1373:
1369:
1364:
1359:
1354:
1349:
1345:
1341:
1337:
1329:
1326:
1321:
1317:
1313:
1309:
1305:
1304:10.1038/45590
1301:
1297:
1293:
1289:
1285:
1278:
1274:
1269:
1264:
1259:
1254:
1250:
1246:
1242:
1238:
1234:
1227:
1224:
1219:
1213:
1210:
1205:
1201:
1197:
1193:
1189:
1185:
1177:
1174:
1169:
1165:
1161:
1157:
1153:
1149:
1141:
1138:
1133:
1129:
1123:
1120:
1116:
1112:
1107:
1105:
1103:
1099:
1092:
1087:
1084:
1081:
1078:
1075:
1072:
1069:
1066:
1063:
1060:
1057:
1054:
1053:
1052:
1050:
1042:
1040:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
995:
991:
987:
979:
977:
975:
972:
968:
964:
950:
946:
942:
939:
935:
925:
923:
920:
916:
910:
907:
903:
899:
892:
886:
882:
879:
873:
871:
867:
863:
859:
855:
849:
845:
841:
837:
833:
829:
825:
822:
818:
811:
805:
801:
798:
792:
790:
786:
782:
776:
772:
769:
767:RefSeq (mRNA)
765:
758:
754:
750:
747:
741:
740:
736:
731:
727:
724:
722:
718:
711:
707:
703:
700:
694:
693:
688:
684:
681:
679:
675:
668:
664:
660:
657:
651:
650:
645:
641:
638:
636:
632:
629:
626:
624:
621:
617:
614:
610:
606:
599:
595:
590:
584:
581:
579:
576:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
549:
546:
544:
541:
540:
538:
535:
534:
528:
525:
523:
520:
518:
515:
513:
510:
508:
505:
503:
502:nuclear speck
500:
498:
495:
494:
492:
489:
488:
482:
479:
477:
474:
472:
469:
467:
464:
462:
459:
457:
454:
453:
451:
448:
447:
444:
443:Gene ontology
440:
436:
424:
419:
415:
410:
407:
405:
401:
393:
388:
378:
375:
371:
368:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
321:
318:
314:
309:
306:
305:
302:
300:
296:
294:
293:
289:
288:
285:
283:
279:
275:
271:
267:
259:
254:
250:
246:
241:
231:
227:
220:
213:
207:
200:
196:
190:
186:
182:
177:
173:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
124:
119:
112:
107:
102:
91:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
2663:
2603:
2545:
2541:
2502:
2498:
2459:
2455:
2419:(1): 25–32.
2416:
2413:J. Cell Biol
2412:
2381:
2377:
2338:
2334:
2295:
2291:
2263:10.1038/1700
2257:(1): 46–50.
2254:
2250:
2214:
2210:
2177:
2173:
2138:
2134:
2095:
2092:J. Cell Biol
2091:
2044:
2040:
2001:
1997:
1966:
1962:
1925:
1921:
1886:
1882:
1833:
1829:
1782:(1): 25–32.
1779:
1776:J. Cell Biol
1775:
1765:
1720:
1716:
1706:
1665:
1661:
1654:
1627:
1623:
1613:
1588:
1584:
1578:
1551:
1547:
1537:
1502:
1498:
1488:
1453:
1449:
1439:
1394:
1390:
1380:
1343:
1339:
1328:
1287:
1283:
1240:
1236:
1226:
1212:
1187:
1183:
1176:
1151:
1147:
1140:
1131:
1122:
1046:
1043:Interactions
1025:zinc fingers
1020:
983:
970:
962:
961:
888:
866:NP_001020375
862:NP_001020374
854:NP_001020375
851:
844:NP_001020374
840:NP_001307580
836:NP_001307579
832:NP_001307577
828:NP_001307575
807:
785:NM_001025204
781:NM_001025203
778:
756:
733:
709:
690:
666:
647:
627:
622:
568:RNA splicing
512:U2AF complex
297:
290:
126:External IDs
85:
26:
2646:PDB gallery
2548:(1): 5712.
2203:Potashkin J
2174:J. Cell Sci
1397:(1): 5712.
1005:spliceosome
517:nucleoplasm
476:RNA binding
359:granulocyte
331:bone marrow
256:43,107,570
243:43,092,956
104:Identifiers
2251:Nat. Genet
2201:Gozani O,
1117:, May 2017
1093:References
1007:assembly.
497:Cajal body
351:right lung
301:(ortholog)
139:HomoloGene
1963:Genes Dev
870:NP_006749
858:NP_006749
789:NM_006758
613:Orthologs
147:GeneCards
2681:Category
2580:31836708
2529:11533230
2486:11500380
2443:11448987
2400:11118443
2365:11060040
1950:22951690
1806:11448987
1690:16189514
1646:18211889
1605:15474994
1570:11724776
1431:31836708
1372:22980975
1312:10617206
1148:Genomics
1113:–
1049:interact
1013:isoforms
1001:pre-mRNA
980:Function
938:Wikidata
592:Sources:
355:monocyte
343:appendix
2610:PDBe-KB
2600:UniProt
2571:6911043
2550:Bibcode
2434:2196870
2322:9799243
2313:1170960
2271:9731529
2241:9671485
2194:9645944
2165:9528748
2122:9472028
2113:2141757
2079:4386808
2071:9237760
2049:Bibcode
2028:9016565
1985:8647433
1942:8261509
1913:1824937
1870:1388271
1838:Bibcode
1797:2196870
1757:1388271
1725:Bibcode
1698:4427026
1670:Bibcode
1529:8816452
1480:9799243
1471:1170960
1422:6911043
1399:Bibcode
1363:3557932
1320:4405416
1292:Bibcode
1277:2531895
1245:Bibcode
1204:7956352
1168:8660980
1115:Ensembl
1056:ASF/SF2
999:to the
967:protein
721:UniProt
678:Ensembl
619:Species
598:QuickGO
527:nucleus
276:pattern
235:21q22.3
111:Aliases
2605:Q01081
2578:
2568:
2527:
2517:
2484:
2477:125580
2474:
2456:EMBO J
2441:
2431:
2398:
2363:
2356:305781
2353:
2335:EMBO J
2320:
2310:
2292:EMBO J
2279:585778
2277:
2269:
2239:
2232:109061
2229:
2192:
2163:
2156:121406
2153:
2120:
2110:
2077:
2069:
2041:Nature
2026:
2019:146436
2016:
1983:
1948:
1940:
1911:
1904:452631
1901:
1883:EMBO J
1868:
1858:
1804:
1794:
1755:
1745:
1696:
1688:
1662:Nature
1644:
1603:
1568:
1527:
1520:231539
1517:
1478:
1468:
1450:EMBO J
1429:
1419:
1370:
1360:
1318:
1310:
1284:Nature
1275:
1268:298470
1265:
1202:
1166:
1086:ZRANB2
1082:, and
1074:SMNDC1
1051:with:
921:search
919:PubMed
739:P0DN76
735:Q01081
635:Entrez
404:BioGPS
143:134334
135:191317
2520:99788
2275:S2CID
2075:S2CID
1946:S2CID
1861:50002
1748:50002
1694:S2CID
1316:S2CID
1080:U2AF2
1021:U2AF1
997:snRNP
990:U2AF2
971:U2AF1
965:is a
628:Mouse
623:Human
594:Amigo
299:Mouse
292:Human
239:Start
172:Human
151:U2AF1
118:U2AF1
35:U2AF1
18:U2AF1
2664:1jmt
2598:for
2576:PMID
2525:PMID
2482:PMID
2439:PMID
2396:PMID
2361:PMID
2318:PMID
2267:PMID
2237:PMID
2190:PMID
2161:PMID
2118:PMID
2067:PMID
2024:PMID
1981:PMID
1938:PMID
1922:Cell
1909:PMID
1866:PMID
1802:PMID
1753:PMID
1686:PMID
1642:PMID
1601:PMID
1566:PMID
1525:PMID
1476:PMID
1427:PMID
1368:PMID
1340:Cell
1308:PMID
1273:PMID
1237:PNAS
1200:PMID
1164:PMID
1062:NXF1
1029:ROS1
974:gene
649:7307
282:Bgee
230:Band
189:Chr.
131:OMIM
88:1JMT
69:RCSB
66:PDBe
2596:PDB
2566:PMC
2558:doi
2515:PMC
2507:doi
2472:PMC
2464:doi
2429:PMC
2421:doi
2417:154
2386:doi
2382:276
2351:PMC
2343:doi
2308:PMC
2300:doi
2259:doi
2227:PMC
2219:doi
2182:doi
2178:111
2151:PMC
2143:doi
2108:PMC
2100:doi
2096:140
2057:doi
2045:388
2014:PMC
2006:doi
1971:doi
1930:doi
1899:PMC
1891:doi
1856:PMC
1846:doi
1792:PMC
1784:doi
1780:154
1743:PMC
1733:doi
1678:doi
1666:437
1632:doi
1628:283
1593:doi
1589:300
1556:doi
1552:277
1515:PMC
1507:doi
1466:PMC
1458:doi
1417:PMC
1407:doi
1358:PMC
1348:doi
1344:150
1300:doi
1288:402
1263:PMC
1253:doi
1192:doi
1156:doi
1068:RP9
1039:}.
1019:in
927:n/a
912:n/a
890:n/a
809:n/a
757:n/a
710:n/a
667:n/a
379:n/a
252:End
155:OMA
59:PDB
2683::
2602::
2574:.
2564:.
2556:.
2546:10
2544:.
2540:.
2523:.
2513:.
2503:21
2501:.
2497:.
2480:.
2470:.
2460:20
2458:.
2454:.
2437:.
2427:.
2415:.
2411:.
2394:.
2380:.
2376:.
2359:.
2349:.
2339:19
2337:.
2333:.
2316:.
2306:.
2296:17
2294:.
2290:.
2273:.
2265:.
2255:20
2253:.
2235:.
2225:.
2215:18
2213:.
2209:.
2188:.
2176:.
2159:.
2149:.
2139:18
2137:.
2133:.
2116:.
2106:.
2094:.
2090:.
2073:.
2065:.
2055:.
2043:.
2039:.
2022:.
2012:.
2002:25
2000:.
1996:.
1979:.
1967:10
1965:.
1961:.
1944:.
1936:.
1926:75
1924:.
1907:.
1897:.
1887:10
1885:.
1881:.
1864:.
1854:.
1844:.
1834:89
1832:.
1828:.
1800:.
1790:.
1778:.
1774:.
1751:.
1741:.
1731:.
1721:89
1719:.
1715:.
1692:.
1684:.
1676:.
1664:.
1640:.
1626:.
1622:.
1599:.
1587:.
1564:.
1550:.
1546:.
1523:.
1513:.
1503:16
1501:.
1497:.
1474:.
1464:.
1454:17
1452:.
1448:.
1425:.
1415:.
1405:.
1395:10
1393:.
1389:.
1366:.
1356:.
1342:.
1338:.
1314:.
1306:.
1298:.
1286:.
1271:.
1261:.
1251:.
1241:86
1239:.
1235:.
1198:.
1188:68
1186:.
1162:.
1152:33
1150:.
1130:.
1101:^
994:U2
986:SR
976:.
596:/
258:bp
245:bp
153:;
149::
145:;
141::
137:;
133::
2639:e
2632:t
2625:v
2612:.
2582:.
2560::
2552::
2531:.
2509::
2488:.
2466::
2445:.
2423::
2402:.
2388::
2367:.
2345::
2324:.
2302::
2281:.
2261::
2243:.
2221::
2196:.
2184::
2167:.
2145::
2124:.
2102::
2081:.
2059::
2051::
2030:.
2008::
1987:.
1973::
1952:.
1932::
1915:.
1893::
1872:.
1848::
1840::
1808:.
1786::
1759:.
1735::
1727::
1700:.
1680::
1672::
1648:.
1634::
1607:.
1595::
1572:.
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20:)
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