297:
274:
171:
196:
303:
202:
1291:, as well as cancer and tumors. Since UBA1 is involved in multiple biological processes, there are concerns that inhibiting UBA1 would also damage normal cells. Nonetheless, preclinical testing of a UBA1 inhibitor in mice with leukemia revealed no additional toxic effects to normal cells, and the success of other drugs targeting pleiotropic targets likewise support the safety of using UBA1 inhibitor in cancer treatment
1298:, as well as its ketone and ester derivatives, preferentially targets cancer over normal cells by specifically blocking the ligation of Ub and UBA1 during the adenylation step of the E1 pathway. MLN4924, a NEDD8-activating enzyme inhibitor functioning according to similar mechanisms, is currently undergoing phase I clinical trials.
2294:
Yamanokuchi R, Imada K, Miyazaki M, Kato H, Watanabe T, Fujimuro M, Saeki Y, Yoshinaga S, Terasawa H, Iwasaki N, Rotinsulu H, Losung F, Mangindaan RE, Namikoshi M, de Voogd NJ, Yokosawa H, Tsukamoto S (July 2012). "Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme,
2107:
Powis, Rachael A.; Karyka, Evangelia; Boyd, Penelope; Côme, Julien; Jones, Ross A.; Zheng, Yinan; Szunyogova, Eva; Groen, Ewout J.N.; Hunter, Gillian; Thomson, Derek; Wishart, Thomas M.; Becker, Catherina G.; Parson, Simon H.; Martinat, Cécile; Azzouz, Mimoun; Gillingwater, Thomas H. (2016).
50:
2433:
Xia T, Dimitropoulou C, Zeng J, Antonova GN, Snead C, Venema RC, Fulton D, Qian S, Patterson C, Papapetropoulos A, Catravas JD (November 2007). "Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase".
2771:
Carbia-Nagashima A, Gerez J, Perez-Castro C, Paez-Pereda M, Silberstein S, Stalla GK, Holsboer F, Arzt E (October 2007). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia".
1223:
bundle that represents a second insertion in the inactive adenylation domain and immediately follows the first catalytic cysteine half-domain; and fourth, the C-terminal ubiquitin-fold domain, which recruits specific E2s.
2160:
Beck, David B.; Ferrada, Marcela A.; Sikora, Keith A.; Ombrello, Amanda K.; Collins, Jason C.; Pei, Wuhong; Balanda, Nicholas; Ross, Daron L.; Ospina
Cardona, Daniela; Wu, Zhijie; Patel, Bhavisha (2020-10-27).
1264:, DNA damage repair, and transcriptional regulation. Additionally, UBA1 helps regulate the NEDD8 pathway, thus implicating it in protein folding, as well as mitigating the depletion of ubiquitin levels during
1454:
Kudo M, Sugasawa K, Hori T, Enomoto T, Hanaoka F, Ui M (January 1991). "Human ubiquitin-activating enzyme (E1): compensation for heat-labile mouse E1 and its gene localization on the X chromosome".
3006:
Bruce MC, Kanelis V, Fouladkou F, Debonneville A, Staub O, Rotin D (October 2008). "Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain".
3130:
2218:
Qin Z, Cui B, Jin J, Song M, Zhou B, Guo H, Qian D, He Y, Huang L (April 2016). "The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis".
3383:
2506:
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".
1244:
bond between the two. It also continues to participate in subsequent steps of ubiquination as a Ub carrier. There are only two human ubiquitin-activating enzymes, UBA1 and
2977:
Wang X, Shi Y, Wang J, Huang G, Jiang X (September 2008). "Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation".
310:
209:
2819:
Ramser J, Ahearn ME, Lenski C, Yariz KO, Hellebrand H, von Rhein M, Clark RD, Schmutzler RK, Lichtner P, Hoffman EP, Meindl A, Baumbach-Reardon L (January 2008).
1546:"Structural model of the hUbA1-UbcH10 quaternary complex: in silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin"
3123:
3098:
1873:
Walden H, Podgorski MS, Schulman BA (March 2003). "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8".
797:
132:
2905:
Nicassio F, Corrado N, Vissers JH, Areces LB, Bergink S, Marteijn JA, Geverts B, Houtsmuller AB, Vermeulen W, Di Fiore PP, Citterio E (November 2007).
778:
3116:
1284:
1127:
3728:
1248:, and thus UBA1 is largely responsible for protein ubiquitination in humans. Through its central role in ubiquitination, UBA1 has been linked to
1207:
half of the UBA1 for Ub, or the separate subunits of the UBA1 for NEDD8 and SUMO. The UBA1 for Ub consists of four building blocks: First, the
1417:
1399:
3971:
2666:
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H (March 2008).
47:
296:
3946:
1544:
Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B (2014).
2590:"Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1"
1033:
2388:
Jin J, Li X, Gygi SP, Harper JW (June 2007). "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging".
1305:(vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is due to mutation in methionine41 in UBA1, the E1 enzyme that initiates
1040:
1764:
273:
2701:
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006).
1440:
3139:
2625:"Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation"
1386:
1365:
103:, A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X, ubiquitin like modifier activating enzyme 1, VEXAS
3339:
1382:
195:
170:
2940:
Su ZL, Mo XL, Feng ZY, Lin HL, Ding YG (September 2008). "UBE1 expression in extranodal NK/T cell lymphoma, nasal type".
1361:
3552:
2465:"Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes"
112:
3497:
1219:
half-domains, which contain the E1 active site cysteine inserted into each of the adenylation domains; third, a four-
2794:
2337:"Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme"
309:
208:
3037:"Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation"
302:
201:
3437:
3089:
2862:
Zenke-Kawasaki Y, Dohi Y, Katoh Y, Ikura T, Ikura M, Asahara T, Tokunaga F, Iwai K, Igarashi K (October 2007).
2703:"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration"
1675:"The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer"
842:
120:
2821:"Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy"
3762:
1288:
823:
3934:
3803:
1614:
Ungermannova D, Parker SJ, Nasveschuk CG, Wang W, Quade B, Zhang G, Kuchta RD, Phillips AJ, Liu X (2012).
1212:
1172:
3184:
1826:"Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1"
2397:
2348:
2019:
1882:
1779:
1627:
1557:
184:
99:
2109:
3147:
1257:
1012:
1008:
1004:
949:
945:
941:
2255:"Search for Inhibitors of the Ubiquitin-Proteasome System from Natural Sources for Cancer Therapy"
3793:
3161:
3085:
2965:
2807:
2531:
2421:
1906:
1803:
144:
1724:"Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes"
1016:
983:
979:
953:
920:
916:
1295:
3463:
3066:
3023:
2994:
2957:
2928:
2893:
2850:
2799:
2759:
2724:
2689:
2654:
2611:
2576:
2523:
2494:
2451:
2413:
2376:
2312:
2276:
2235:
2200:
2182:
2142:
2089:
2045:
1988:
1947:
1898:
1855:
1795:
1765:"Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex"
1745:
1704:
1655:
1585:
1515:
1471:
92:
40:
1240:. Specifically, UBA1 catalyzes the ATP-dependent adenylation of ubiquitin, thereby forming a
3723:
3682:
3677:
3652:
3642:
3637:
3627:
3427:
3056:
3048:
3035:
Zhou W, Zhu P, Wang J, Pascual G, Ohgi KA, Lozach J, Glass CK, Rosenfeld MG (January 2008).
3015:
2986:
2949:
2918:
2883:
2875:
2840:
2832:
2789:
2781:
2749:
2714:
2679:
2644:
2636:
2601:
2566:
2556:
2515:
2484:
2476:
2443:
2405:
2366:
2356:
2304:
2266:
2227:
2190:
2174:
2132:
2124:
2079:
2035:
2027:
1978:
1937:
1890:
1845:
1837:
1787:
1735:
1694:
1686:
1645:
1635:
1575:
1565:
1505:
1463:
1265:
389:
320:
264:
219:
3698:
3632:
1321:
3929:
3152:
2907:"Human USP3 is a chromatin modifier required for S phase progression and genome stability"
2231:
1336:
1196:
1192:
1119:
364:
140:
2401:
2352:
2023:
1886:
1783:
1631:
1561:
1494:"The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions"
3476:
3471:
3061:
3036:
2888:
2863:
2845:
2820:
2649:
2624:
2571:
2545:"ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response"
2544:
2489:
2464:
2371:
2336:
2195:
2162:
2137:
2040:
2007:
1699:
1674:
1650:
1615:
1580:
1545:
1302:
1188:
1123:
1850:
1825:
712:
707:
702:
697:
692:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
610:
605:
600:
595:
590:
585:
580:
3965:
3102:
2480:
2066:
Moudry P, Lukas C, Macurek L, Hanzlikova H, Hodny Z, Lukas J, Bartek J (April 2012).
1467:
1331:
1180:
567:
2811:
2736:
Gallegos JR, Litersky J, Lee H, Sun Y, Nakayama K, Nakayama K, Lu H (January 2008).
2535:
1616:"Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1)"
3832:
3814:
2969:
2425:
1910:
1807:
1176:
382:
161:
2068:"Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage"
1965:
Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA (February 2005).
124:
3108:
3052:
2606:
2589:
1983:
1967:"Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1"
1966:
1640:
1570:
148:
3908:
3776:
2447:
1422:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1404:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1253:
1237:
1208:
2864:"Heme induces ubiquitination and degradation of the transcription factor Bach1"
2836:
2785:
2719:
2702:
2684:
2667:
2341:
Proceedings of the
National Academy of Sciences of the United States of America
1740:
1723:
1690:
1287:. UBA1 has also been implicated in other neurodegenerative diseases, including
465:
3738:
3166:
2953:
2923:
2906:
2308:
2128:
1249:
1204:
1200:
1184:
1152:
281:
178:
128:
2186:
2110:"Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy"
2008:"Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity"
1841:
1211:
domains composed of two MoeB/ThiF-homology motifs, the latter of which binds
3486:
3432:
2640:
2361:
2006:
Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA (January 2007).
1306:
1261:
1241:
1233:
1168:
1111:
742:
525:
403:
348:
335:
247:
234:
136:
3070:
3027:
2998:
2961:
2932:
2897:
2854:
2803:
2763:
2754:
2737:
2728:
2693:
2658:
2615:
2580:
2561:
2527:
2498:
2455:
2417:
2380:
2316:
2280:
2239:
2204:
2163:"Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease"
2146:
2093:
2049:
1992:
1951:
1942:
1925:
1902:
1859:
1799:
1749:
1659:
1589:
1519:
2271:
2254:
2178:
1708:
1510:
1493:
1475:
1080:
1075:
3766:
3399:
3391:
2879:
1276:
1216:
1126:, among many other biological processes. This protein has been linked to
1064:
891:
872:
868:
2409:
2031:
1894:
3517:
3404:
3364:
3295:
3290:
3285:
3280:
3275:
3230:
3019:
2990:
1131:
854:
809:
1926:"Crystal structure of a fragment of mouse ubiquitin-activating enzyme"
69:
3733:
3708:
3703:
3693:
3657:
3647:
3622:
3607:
3602:
3597:
3592:
3587:
3582:
3577:
3572:
3537:
3522:
3369:
3334:
3319:
3314:
3309:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3225:
3220:
3215:
3210:
3205:
2084:
2067:
1791:
1326:
1245:
1100:
1048:
764:
2519:
1763:
Lake MW, Wuebbens MM, Rajagopalan KV, Schindelin H (November 2001).
1492:
Leidecker O, Matic I, Mahata B, Pion E, Xirodimas DP (March 2012).
3924:
3914:
3904:
3889:
3871:
3866:
3861:
3856:
3788:
3748:
3713:
3687:
3672:
3667:
3662:
3617:
3612:
3567:
3562:
3557:
3527:
3512:
3409:
3378:
3359:
3354:
3349:
3344:
3329:
3324:
3304:
3200:
3193:
3189:
3179:
3174:
1673:
Johnson ES, Schwienhorst I, Dohmen RJ, Blobel G (September 1997).
1220:
1156:
1115:
727:
723:
3939:
3919:
3899:
3894:
3844:
3827:
3783:
3771:
3753:
3743:
3542:
3532:
3507:
3502:
3447:
3442:
2436:
American
Journal of Physiology. Heart and Circulatory Physiology
1107:
116:
3112:
1236:
conjugation, or ubiquitination, to mark cellular proteins for
1171:(Ub) is a 110–120 kDa monomeric protein, and the UBA1 for the
2463:
Pridgeon JW, Webber EA, Sha D, Li L, Chin LS (January 2009).
1232:
The protein encoded by this gene catalyzes the first step in
2668:"Toward a confocal subcellular atlas of the human proteome"
1301:
An autoinflammatory condition identified in 2020 and named
1441:"Entrez Gene: ubiquitin-like modifier activating enzyme 1"
2795:
20.500.12110/paper_00928674_v131_n2_p309_CarbiaNagashima
372:
2623:
Umebayashi K, Stenmark H, Yoshimori T (August 2008).
1924:
Szczepanowski RH, Filipek R, Bochtler M (June 2005).
537:
3882:
3813:
3802:
3485:
3462:
3420:
3160:
3146:
1609:
1607:
1605:
1603:
1601:
1599:
997:
972:
934:
909:
488:
dentate gyrus of hippocampal formation granule cell
2738:"SCF TrCP1 activates and ubiquitylates TAp63gamma"
2588:Anindya R, Aygün O, Svejstrup JQ (November 2007).
1378:
1376:
1374:
1357:
1355:
1353:
596:ubiquitin-like modifier activating enzyme activity
708:protein modification by small protein conjugation
319:
218:
1487:
1485:
2061:
2059:
1819:
1817:
1539:
1537:
1535:
1533:
1531:
1529:
16:Protein-coding gene in the species Homo sapiens
1383:GRCm38: Ensembl release 89: ENSMUSG00000001924
1183:complexes with similar molecular weights. All
3124:
2295:from the marine sponge Hyrtios reticulatus".
703:ubiquitin-dependent protein catabolic process
8:
1362:GRCh38: Ensembl release 89: ENSG00000130985
1093:Ubiquitin-like modifier activating enzyme 1
3810:
3157:
3131:
3117:
3109:
3099:United States National Library of Medicine
1199:proteins, with one occurrence each in the
738:
563:
360:
259:
156:
58:
3088:at the U.S. National Library of Medicine
3060:
2922:
2887:
2844:
2793:
2753:
2718:
2683:
2648:
2605:
2570:
2560:
2488:
2370:
2360:
2335:Nouspikel T, Hanawalt PC (October 2006).
2270:
2194:
2136:
2083:
2039:
1982:
1941:
1849:
1739:
1698:
1649:
1639:
1579:
1569:
1509:
3097:This article incorporates text from the
1435:
1433:
1431:
693:cellular response to DNA damage stimulus
1349:
1285:X-linked spinal muscular atrophy type 2
1128:X-linked spinal muscular atrophy type 2
2259:Chemical & Pharmaceutical Bulletin
1317:UBA1 has been shown to interact with:
18:
2543:Malakhova OA, Zhang DE (April 2008).
2232:10.1016/j.atherosclerosis.2016.02.016
324:
285:
280:
223:
182:
177:
7:
2297:Bioorganic & Medicinal Chemistry
1187:UBA1 contain a two-fold repeat of a
632:rough endoplasmic reticulum membrane
606:ubiquitin activating enzyme activity
2742:The Journal of Biological Chemistry
2672:Molecular & Cellular Proteomics
2549:The Journal of Biological Chemistry
1930:The Journal of Biological Chemistry
3947:Prokaryotic ubiquitin-like protein
2825:American Journal of Human Genetics
1824:Lois LM, Lima CD (February 2005).
1130:, neurodegenerative diseases, and
1103:which in humans is encoded by the
994:
969:
931:
906:
882:
859:
833:
814:
788:
769:
542:
512:choroid plexus of fourth ventricle
460:
398:
377:
14:
1722:Lee I, Schindelin H (July 2008).
2481:10.1111/j.1742-4658.2008.06760.x
308:
301:
295:
272:
207:
200:
194:
169:
2167:New England Journal of Medicine
1155:band Xp11.23, consisting of 31
3477:Mitochondrial targeting signal
3140:Posttranslational modification
2868:Molecular and Cellular Biology
1215:and Ub; second, the catalytic
526:More reference expression data
1:
2629:Molecular Biology of the Cell
1294:Moreover, the UBA1 inhibitor
1191:, derived from the bacterial
293:
192:
3553:Ubiquitin-conjugating enzyme
3053:10.1016/j.molcel.2007.11.002
2607:10.1016/j.molcel.2007.10.008
1984:10.1016/j.molcel.2004.12.020
1641:10.1371/journal.pone.0029208
1571:10.1371/journal.pone.0112082
1468:10.1016/0014-4827(91)90164-P
3972:Genes on human chromosome X
3841:E2 SUMO-conjugating enzyme
3498:Ubiquitin-activating enzyme
2448:10.1152/ajpheart.00579.2007
426:right lobe of thyroid gland
3988:
3824:E1 SUMO-activating enzyme
2837:10.1016/j.ajhg.2007.09.009
2786:10.1016/j.cell.2007.07.044
2720:10.1016/j.cell.2006.03.032
2685:10.1074/mcp.M700325-MCP200
1741:10.1016/j.cell.2008.05.046
1456:Experimental Cell Research
2954:10.1080/10428190802187171
2924:10.1016/j.cub.2007.10.034
2309:10.1016/j.bmc.2012.05.044
2129:10.1172/jci.insight.87908
1418:"Mouse PubMed Reference:"
1400:"Human PubMed Reference:"
1079:
1074:
1070:
1063:
1047:
1028:
1001:
976:
965:
938:
913:
902:
889:
885:
866:
862:
853:
840:
836:
821:
817:
808:
795:
791:
776:
772:
763:
748:
741:
737:
721:
566:
562:
550:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
3438:Survival of motor neuron
3090:Medical Subject Headings
1842:10.1038/sj.emboj.7600552
1691:10.1093/emboj/16.18.5509
3804:Ubiquitin-like proteins
3763:Deubiquitinating enzyme
3008:The Biochemical Journal
2979:The Biochemical Journal
2942:Leukemia & Lymphoma
2641:10.1091/mbc.E07-10-0988
2362:10.1073/pnas.0607769103
1289:spinal muscular atrophy
1151:gene is located in the
1110:. UBA1 participates in
1041:Chr X: 20.52 – 20.55 Mb
1034:Chr X: 47.19 – 47.22 Mb
2755:10.1074/jbc.M704686200
2562:10.1074/jbc.C800030200
1943:10.1074/jbc.M502583200
1173:ubiquitin-like protein
698:protein ubiquitination
326:X A1.3|X 16.15 cM
2272:10.1248/cpb.c15-00768
2179:10.1056/NEJMoa2026834
1511:10.4161/cc.11.6.19559
1272:Clinical significance
662:extracellular exosome
2880:10.1128/MCB.02415-06
2508:Nature Biotechnology
2253:Tsukamoto S (2016).
1283:are associated with
287:X chromosome (mouse)
185:X chromosome (human)
62:List of PDB id codes
35:Available structures
3162:Heat shock proteins
3086:UBE1+Protein,+human
2410:10.1038/nature05902
2402:2007Natur.447.1135J
2353:2006PNAS..10316188N
2032:10.1038/nature05490
2024:2007Natur.445..394H
1895:10.1038/nature01456
1887:2003Natur.422..330W
1784:2001Natur.414..325L
1632:2012PLoSO...729208U
1562:2014PLoSO...9k2082C
1258:signal transduction
480:ganglionic eminence
450:trigeminal ganglion
430:ganglionic eminence
3101:, which is in the
3020:10.1042/BJ20071708
2991:10.1042/BJ20080674
843:ENSMUSG00000001924
686:Biological process
647:lysosomal membrane
620:Cellular component
581:nucleotide binding
574:Molecular function
442:right uterine tube
3959:
3958:
3955:
3954:
3464:Protein targeting
3458:
3457:
2173:(27): 2628–2638.
1175:(Ubls) NEDD8 and
1090:
1089:
1086:
1085:
1059:
1058:
1024:
1023:
991:
990:
961:
960:
928:
927:
898:
897:
879:
878:
849:
848:
830:
829:
804:
803:
785:
784:
733:
732:
657:endosome membrane
558:
557:
554:
553:
532:
531:
519:
518:
457:
456:
438:postcentral gyrus
418:mucosa of pharynx
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
3979:
3811:
3724:Ubiquitin ligase
3490:(ubiquitylation)
3428:Alpha crystallin
3158:
3133:
3126:
3119:
3110:
3074:
3064:
3031:
3002:
2973:
2936:
2926:
2901:
2891:
2858:
2848:
2815:
2797:
2767:
2757:
2732:
2722:
2697:
2687:
2662:
2652:
2619:
2609:
2584:
2574:
2564:
2539:
2502:
2492:
2469:The FEBS Journal
2459:
2429:
2396:(7148): 1135–8.
2384:
2374:
2364:
2347:(44): 16188–93.
2321:
2320:
2291:
2285:
2284:
2274:
2250:
2244:
2243:
2215:
2209:
2208:
2198:
2157:
2151:
2150:
2140:
2114:
2104:
2098:
2097:
2087:
2085:10.4161/cc.19978
2063:
2054:
2053:
2043:
2003:
1997:
1996:
1986:
1962:
1956:
1955:
1945:
1936:(23): 22006–11.
1921:
1915:
1914:
1870:
1864:
1863:
1853:
1830:The EMBO Journal
1821:
1812:
1811:
1792:10.1038/35104586
1769:
1760:
1754:
1753:
1743:
1719:
1713:
1712:
1702:
1679:The EMBO Journal
1670:
1664:
1663:
1653:
1643:
1611:
1594:
1593:
1583:
1573:
1541:
1524:
1523:
1513:
1489:
1480:
1479:
1451:
1445:
1444:
1437:
1426:
1425:
1414:
1408:
1407:
1396:
1390:
1380:
1369:
1359:
1337:hyrtioreticulins
1072:
1071:
1043:
1036:
1019:
995:
986:
970:
966:RefSeq (protein)
956:
932:
923:
907:
883:
860:
834:
815:
789:
770:
739:
564:
543:
528:
496:ventricular zone
484:genital tubercle
468:
466:Top expressed in
461:
422:ventricular zone
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
149:UBA1 - orthologs
102:
95:
72:
59:
53:
32:
31:
19:
3987:
3986:
3982:
3981:
3980:
3978:
3977:
3976:
3962:
3961:
3960:
3951:
3878:
3853:E3 SUMO ligase
3817:
3806:
3798:
3489:
3481:
3454:
3416:
3395:
3387:
3165:
3153:protein folding
3151:
3142:
3137:
3082:
3077:
3034:
3005:
2976:
2939:
2911:Current Biology
2904:
2874:(19): 6962–71.
2861:
2818:
2770:
2735:
2700:
2665:
2622:
2587:
2542:
2520:10.1038/nbt1240
2514:(10): 1285–92.
2505:
2462:
2432:
2387:
2334:
2330:
2328:Further reading
2325:
2324:
2303:(14): 4437–42.
2293:
2292:
2288:
2252:
2251:
2247:
2220:Atherosclerosis
2217:
2216:
2212:
2159:
2158:
2154:
2112:
2106:
2105:
2101:
2065:
2064:
2057:
2018:(7126): 394–8.
2005:
2004:
2000:
1964:
1963:
1959:
1923:
1922:
1918:
1881:(6929): 330–4.
1872:
1871:
1867:
1823:
1822:
1815:
1778:(6861): 325–9.
1767:
1762:
1761:
1757:
1721:
1720:
1716:
1685:(18): 5509–19.
1672:
1671:
1667:
1613:
1612:
1597:
1556:(11): e112082.
1543:
1542:
1527:
1491:
1490:
1483:
1453:
1452:
1448:
1439:
1438:
1429:
1416:
1415:
1411:
1398:
1397:
1393:
1381:
1372:
1360:
1351:
1346:
1315:
1274:
1230:
1165:
1145:
1140:
1120:protein folding
1081:View/Edit Mouse
1076:View/Edit Human
1039:
1032:
1029:Location (UCSC)
1015:
1011:
1007:
1003:
982:
978:
952:
948:
944:
940:
919:
915:
871:
824:ENSG00000130985
717:
681:
642:heterochromatin
615:
591:protein binding
586:ligase activity
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
444:
440:
436:
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
3985:
3983:
3975:
3974:
3964:
3963:
3957:
3956:
3953:
3952:
3950:
3949:
3943:
3942:
3937:
3932:
3927:
3922:
3917:
3912:
3902:
3897:
3892:
3886:
3884:
3880:
3879:
3877:
3876:
3875:
3874:
3869:
3864:
3859:
3850:
3849:
3848:
3847:
3838:
3837:
3836:
3835:
3830:
3821:
3819:
3808:
3800:
3799:
3797:
3796:
3791:
3786:
3780:
3779:
3774:
3769:
3759:
3758:
3757:
3756:
3751:
3746:
3741:
3736:
3731:
3719:
3718:
3717:
3716:
3711:
3706:
3701:
3696:
3691:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3548:
3547:
3546:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3493:
3491:
3483:
3482:
3480:
3479:
3474:
3472:Signal peptide
3468:
3466:
3460:
3459:
3456:
3455:
3453:
3452:
3451:
3450:
3445:
3435:
3430:
3424:
3422:
3418:
3417:
3415:
3414:
3413:
3412:
3407:
3402:
3397:
3393:
3389:
3385:
3375:
3374:
3373:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3322:
3317:
3312:
3301:
3300:
3299:
3298:
3293:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3228:
3223:
3218:
3213:
3208:
3197:
3196:
3187:
3182:
3177:
3171:
3169:
3155:
3144:
3143:
3138:
3136:
3135:
3128:
3121:
3113:
3094:
3093:
3081:
3080:External links
3078:
3076:
3075:
3041:Molecular Cell
3032:
3003:
2974:
2937:
2917:(22): 1972–7.
2902:
2859:
2816:
2768:
2733:
2698:
2678:(3): 499–508.
2663:
2635:(8): 3454–62.
2620:
2594:Molecular Cell
2585:
2555:(14): 8783–7.
2540:
2503:
2460:
2442:(5): H3080–7.
2430:
2385:
2331:
2329:
2326:
2323:
2322:
2286:
2245:
2210:
2152:
2123:(11): e87908.
2099:
2078:(8): 1573–82.
2055:
1998:
1971:Molecular Cell
1957:
1916:
1865:
1813:
1755:
1714:
1665:
1595:
1525:
1504:(6): 1142–50.
1481:
1446:
1427:
1409:
1391:
1370:
1348:
1347:
1345:
1342:
1341:
1340:
1334:
1329:
1324:
1314:
1311:
1307:ubiquitylation
1303:VEXAS syndrome
1273:
1270:
1229:
1226:
1164:
1161:
1144:
1141:
1139:
1136:
1112:ubiquitination
1088:
1087:
1084:
1083:
1078:
1068:
1067:
1061:
1060:
1057:
1056:
1054:
1052:
1045:
1044:
1037:
1030:
1026:
1025:
1022:
1021:
999:
998:
992:
989:
988:
974:
973:
967:
963:
962:
959:
958:
936:
935:
929:
926:
925:
911:
910:
904:
900:
899:
896:
895:
887:
886:
880:
877:
876:
864:
863:
857:
851:
850:
847:
846:
838:
837:
831:
828:
827:
819:
818:
812:
806:
805:
802:
801:
793:
792:
786:
783:
782:
774:
773:
767:
761:
760:
755:
750:
746:
745:
735:
734:
731:
730:
719:
718:
716:
715:
710:
705:
700:
695:
689:
687:
683:
682:
680:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
623:
621:
617:
616:
614:
613:
608:
603:
598:
593:
588:
583:
577:
575:
571:
570:
560:
559:
556:
555:
552:
551:
548:
547:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
476:tail of embryo
473:
470:
469:
458:
455:
454:
452:
451:
447:
446:spinal ganglia
443:
439:
435:
431:
427:
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3984:
3973:
3970:
3969:
3967:
3948:
3945:
3944:
3941:
3938:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3910:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3887:
3885:
3881:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3854:
3852:
3851:
3846:
3843:
3842:
3840:
3839:
3834:
3831:
3829:
3826:
3825:
3823:
3822:
3820:
3818:(SUMOylation)
3816:
3812:
3809:
3805:
3801:
3795:
3792:
3790:
3787:
3785:
3782:
3781:
3778:
3775:
3773:
3770:
3768:
3764:
3761:
3760:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3726:
3725:
3721:
3720:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3555:
3554:
3550:
3549:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3500:
3499:
3495:
3494:
3492:
3488:
3484:
3478:
3475:
3473:
3470:
3469:
3467:
3465:
3461:
3449:
3446:
3444:
3441:
3440:
3439:
3436:
3434:
3431:
3429:
3426:
3425:
3423:
3419:
3411:
3408:
3406:
3403:
3401:
3398:
3396:
3390:
3388:
3382:
3381:
3380:
3377:
3376:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3316:
3313:
3311:
3308:
3307:
3306:
3303:
3302:
3297:
3294:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3203:
3202:
3199:
3198:
3195:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3172:
3170:
3168:
3163:
3159:
3156:
3154:
3149:
3145:
3141:
3134:
3129:
3127:
3122:
3120:
3115:
3114:
3111:
3107:
3106:
3104:
3103:public domain
3100:
3091:
3087:
3084:
3083:
3079:
3072:
3068:
3063:
3058:
3054:
3050:
3046:
3042:
3038:
3033:
3029:
3025:
3021:
3017:
3014:(1): 155–63.
3013:
3009:
3004:
3000:
2996:
2992:
2988:
2984:
2980:
2975:
2971:
2967:
2963:
2959:
2955:
2951:
2948:(9): 1821–2.
2947:
2943:
2938:
2934:
2930:
2925:
2920:
2916:
2912:
2908:
2903:
2899:
2895:
2890:
2885:
2881:
2877:
2873:
2869:
2865:
2860:
2856:
2852:
2847:
2842:
2838:
2834:
2831:(1): 188–93.
2830:
2826:
2822:
2817:
2813:
2809:
2805:
2801:
2796:
2791:
2787:
2783:
2780:(2): 309–23.
2779:
2775:
2769:
2765:
2761:
2756:
2751:
2747:
2743:
2739:
2734:
2730:
2726:
2721:
2716:
2713:(4): 801–14.
2712:
2708:
2704:
2699:
2695:
2691:
2686:
2681:
2677:
2673:
2669:
2664:
2660:
2656:
2651:
2646:
2642:
2638:
2634:
2630:
2626:
2621:
2617:
2613:
2608:
2603:
2600:(3): 386–97.
2599:
2595:
2591:
2586:
2582:
2578:
2573:
2568:
2563:
2558:
2554:
2550:
2546:
2541:
2537:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2504:
2500:
2496:
2491:
2486:
2482:
2478:
2475:(1): 118–31.
2474:
2470:
2466:
2461:
2457:
2453:
2449:
2445:
2441:
2437:
2431:
2427:
2423:
2419:
2415:
2411:
2407:
2403:
2399:
2395:
2391:
2386:
2382:
2378:
2373:
2368:
2363:
2358:
2354:
2350:
2346:
2342:
2338:
2333:
2332:
2327:
2318:
2314:
2310:
2306:
2302:
2298:
2290:
2287:
2282:
2278:
2273:
2268:
2264:
2260:
2256:
2249:
2246:
2241:
2237:
2233:
2229:
2225:
2221:
2214:
2211:
2206:
2202:
2197:
2192:
2188:
2184:
2180:
2176:
2172:
2168:
2164:
2156:
2153:
2148:
2144:
2139:
2134:
2130:
2126:
2122:
2118:
2111:
2103:
2100:
2095:
2091:
2086:
2081:
2077:
2073:
2069:
2062:
2060:
2056:
2051:
2047:
2042:
2037:
2033:
2029:
2025:
2021:
2017:
2013:
2009:
2002:
1999:
1994:
1990:
1985:
1980:
1977:(3): 341–50.
1976:
1972:
1968:
1961:
1958:
1953:
1949:
1944:
1939:
1935:
1931:
1927:
1920:
1917:
1912:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1880:
1876:
1869:
1866:
1861:
1857:
1852:
1847:
1843:
1839:
1836:(3): 439–51.
1835:
1831:
1827:
1820:
1818:
1814:
1809:
1805:
1801:
1797:
1793:
1789:
1785:
1781:
1777:
1773:
1766:
1759:
1756:
1751:
1747:
1742:
1737:
1734:(2): 268–78.
1733:
1729:
1725:
1718:
1715:
1710:
1706:
1701:
1696:
1692:
1688:
1684:
1680:
1676:
1669:
1666:
1661:
1657:
1652:
1647:
1642:
1637:
1633:
1629:
1626:(1): e29208.
1625:
1621:
1617:
1610:
1608:
1606:
1604:
1602:
1600:
1596:
1591:
1587:
1582:
1577:
1572:
1567:
1563:
1559:
1555:
1551:
1547:
1540:
1538:
1536:
1534:
1532:
1530:
1526:
1521:
1517:
1512:
1507:
1503:
1499:
1495:
1488:
1486:
1482:
1477:
1473:
1469:
1465:
1461:
1457:
1450:
1447:
1442:
1436:
1434:
1432:
1428:
1423:
1419:
1413:
1410:
1405:
1401:
1395:
1392:
1388:
1384:
1379:
1377:
1375:
1371:
1367:
1363:
1358:
1356:
1354:
1350:
1343:
1338:
1335:
1333:
1332:himeic acid A
1330:
1328:
1325:
1323:
1320:
1319:
1318:
1312:
1310:
1308:
1304:
1299:
1297:
1292:
1290:
1286:
1282:
1278:
1271:
1269:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1227:
1225:
1222:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1186:
1182:
1181:heterodimeric
1178:
1174:
1170:
1167:The UBA1 for
1162:
1160:
1158:
1154:
1150:
1142:
1137:
1135:
1133:
1129:
1125:
1121:
1117:
1113:
1109:
1106:
1102:
1098:
1094:
1082:
1077:
1073:
1069:
1066:
1062:
1055:
1053:
1050:
1046:
1042:
1038:
1035:
1031:
1027:
1020:
1018:
1014:
1010:
1006:
1000:
996:
993:
987:
985:
981:
975:
971:
968:
964:
957:
955:
951:
947:
943:
937:
933:
930:
924:
922:
918:
912:
908:
905:
903:RefSeq (mRNA)
901:
894:
893:
888:
884:
881:
875:
874:
870:
865:
861:
858:
856:
852:
845:
844:
839:
835:
832:
826:
825:
820:
816:
813:
811:
807:
800:
799:
794:
790:
787:
781:
780:
775:
771:
768:
766:
762:
759:
756:
754:
751:
747:
744:
740:
736:
729:
725:
720:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
690:
688:
685:
684:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
652:mitochondrion
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
624:
622:
619:
618:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
569:
568:Gene ontology
565:
561:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
414:renal medulla
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
3815:SUMO protein
3096:
3095:
3047:(1): 69–80.
3044:
3040:
3011:
3007:
2985:(2): 221–9.
2982:
2978:
2945:
2941:
2914:
2910:
2871:
2867:
2828:
2824:
2777:
2773:
2748:(1): 66–75.
2745:
2741:
2710:
2706:
2675:
2671:
2632:
2628:
2597:
2593:
2552:
2548:
2511:
2507:
2472:
2468:
2439:
2435:
2393:
2389:
2344:
2340:
2300:
2296:
2289:
2265:(2): 112–8.
2262:
2258:
2248:
2223:
2219:
2213:
2170:
2166:
2155:
2120:
2116:
2102:
2075:
2071:
2015:
2011:
2001:
1974:
1970:
1960:
1933:
1929:
1919:
1878:
1874:
1868:
1833:
1829:
1775:
1771:
1758:
1731:
1727:
1717:
1682:
1678:
1668:
1623:
1619:
1553:
1549:
1501:
1497:
1462:(1): 110–7.
1459:
1455:
1449:
1421:
1412:
1403:
1394:
1316:
1313:Interactions
1300:
1293:
1280:
1275:
1252:regulation,
1231:
1166:
1148:
1146:
1118:pathway for
1104:
1096:
1092:
1091:
1013:NP_001263246
1009:NP_001263245
1005:NP_001129557
1002:
977:
950:NM_001276317
946:NM_001276316
942:NM_001136085
939:
914:
890:
867:
841:
822:
796:
777:
757:
752:
388:
381:
108:External IDs
67:
3909:neddylation
3175:Hsp10/GroES
3167:Chaperonins
2117:JCI Insight
1254:endocytosis
1238:degradation
1209:adenylation
1124:degradation
672:nucleoplasm
611:RNA binding
601:ATP binding
347:20,549,418
334:20,524,565
246:47,215,128
233:47,190,861
86:Identifiers
3201:Hsp40/DnaJ
3148:Chaperones
2226:: 142–53.
2072:Cell Cycle
1498:Cell Cycle
1389:, May 2017
1368:, May 2017
1344:References
1250:cell cycle
1205:C-terminal
1201:N-terminal
1185:eukaryotic
1153:chromosome
713:metabolism
392:(ortholog)
129:HomoloGene
3487:Ubiquitin
3433:Clusterin
2187:0028-4793
1296:largazole
1277:Mutations
1262:apoptosis
1242:thioester
1234:ubiquitin
1169:ubiquitin
1138:Structure
1017:NP_033483
984:NP_695012
980:NP_003325
954:NM_009457
921:NM_153280
917:NM_003334
743:Orthologs
637:desmosome
627:cytoplasm
492:CA3 field
137:GeneCards
3966:Category
3767:Ataxin 3
3071:18206970
3028:18498246
2999:18498243
2962:18661401
2933:17980597
2898:17682061
2855:18179898
2812:12486303
2804:17956732
2764:17965458
2729:16713569
2694:18029348
2659:18508924
2616:17996703
2581:18287095
2536:14294292
2528:16964243
2499:19019082
2456:17873020
2418:17597759
2381:17060614
2317:22695182
2281:26833439
2240:26919560
2205:33108101
2147:27699224
2094:22456334
2050:17220875
1993:15694336
1952:15774460
1903:12646924
1860:15660128
1800:11713534
1750:18662542
1660:22279528
1620:PLOS ONE
1590:25375166
1550:PLOS ONE
1520:22370482
1385:–
1364:–
1228:Function
1217:cysteine
1114:and the
1099:) is an
1065:Wikidata
722:Sources:
508:habenula
504:epiblast
500:gastrula
3690:(CDC34)
3062:2327256
2970:5481217
2889:2099246
2846:2253959
2650:2488299
2572:2276364
2490:2647816
2426:4337767
2398:Bibcode
2372:1621053
2349:Bibcode
2196:7847551
2138:5033939
2041:2821831
2020:Bibcode
1911:4370095
1883:Bibcode
1808:3224437
1780:Bibcode
1709:9312010
1700:1170183
1651:3261141
1628:Bibcode
1581:4223017
1558:Bibcode
1476:1845793
1387:Ensembl
1366:Ensembl
1163:Protein
1132:cancers
855:UniProt
810:Ensembl
749:Species
728:QuickGO
677:cytosol
667:nucleus
367:pattern
93:Aliases
3734:Cullin
3092:(MeSH)
3069:
3059:
3026:
2997:
2968:
2960:
2931:
2896:
2886:
2853:
2843:
2810:
2802:
2762:
2727:
2692:
2657:
2647:
2614:
2579:
2569:
2534:
2526:
2497:
2487:
2454:
2424:
2416:
2390:Nature
2379:
2369:
2315:
2279:
2238:
2203:
2193:
2185:
2145:
2135:
2092:
2048:
2038:
2012:Nature
1991:
1950:
1909:
1901:
1875:Nature
1858:
1851:548657
1848:
1806:
1798:
1772:Nature
1748:
1707:
1697:
1658:
1648:
1588:
1578:
1518:
1474:
1327:PYR-41
1266:stress
1189:domain
1101:enzyme
1051:search
1049:PubMed
892:Q02053
873:Q5JRS2
869:P22314
765:Entrez
538:BioGPS
434:nipple
225:Xp11.3
117:314370
3925:ATG12
3915:FAT10
3905:NEDD8
3890:ISG15
3883:Other
3872:PIAS4
3867:PIAS3
3862:PIAS2
3857:PIAS1
3807:(UBL)
3789:BIRC6
3749:FANCL
3421:Other
3410:TRAP1
3379:Hsp90
3305:Hsp70
3194:GroEL
3190:HSP60
3185:Hsp47
3180:Hsp27
2966:S2CID
2808:S2CID
2532:S2CID
2422:S2CID
2113:(PDF)
1907:S2CID
1804:S2CID
1768:(PDF)
1322:UBC13
1221:helix
1157:exons
1116:NEDD8
798:22201
758:Mouse
753:Human
724:Amigo
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
133:22002
125:98890
3940:UBL5
3930:FUB1
3920:ATG8
3900:UFM1
3895:URM1
3845:UBC9
3833:SAE2
3828:SAE1
3794:UFC1
3784:ATG3
3777:CYLD
3772:USP6
3754:UBR1
3744:MDM2
3543:SAE1
3538:NAE1
3533:ATG7
3528:UBA7
3523:UBA6
3518:UBA5
3513:UBA3
3508:UBA2
3503:UBA1
3448:SMN2
3443:SMN1
3067:PMID
3024:PMID
2995:PMID
2958:PMID
2929:PMID
2894:PMID
2851:PMID
2800:PMID
2774:Cell
2760:PMID
2725:PMID
2707:Cell
2690:PMID
2655:PMID
2612:PMID
2577:PMID
2524:PMID
2495:PMID
2452:PMID
2414:PMID
2377:PMID
2313:PMID
2277:PMID
2236:PMID
2201:PMID
2183:ISSN
2143:PMID
2090:PMID
2046:PMID
1989:PMID
1948:PMID
1899:PMID
1856:PMID
1796:PMID
1746:PMID
1728:Cell
1705:PMID
1656:PMID
1586:PMID
1516:PMID
1472:PMID
1281:UBA1
1246:UBA6
1203:and
1197:ThiF
1195:and
1193:MoeB
1179:are
1177:SUMO
1149:UBA1
1147:The
1143:Gene
1122:and
1108:gene
1105:UBA1
1097:UBA1
779:7317
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
141:UBA1
113:OMIM
100:UBA1
70:4P22
51:RCSB
48:PDBe
22:UBA1
3935:MUB
3739:CBL
3729:VHL
3722:E3
3551:E2
3496:E1
3365:12A
3296:C19
3291:C14
3286:C13
3281:C11
3276:C10
3231:B11
3057:PMC
3049:doi
3016:doi
3012:415
2987:doi
2983:414
2950:doi
2919:doi
2884:PMC
2876:doi
2841:PMC
2833:doi
2790:hdl
2782:doi
2778:131
2750:doi
2746:283
2715:doi
2711:125
2680:doi
2645:PMC
2637:doi
2602:doi
2567:PMC
2557:doi
2553:283
2516:doi
2485:PMC
2477:doi
2473:276
2444:doi
2440:293
2406:doi
2394:447
2367:PMC
2357:doi
2345:103
2305:doi
2267:doi
2228:doi
2224:247
2191:PMC
2175:doi
2171:383
2133:PMC
2125:doi
2080:doi
2036:PMC
2028:doi
2016:445
1979:doi
1938:doi
1934:280
1891:doi
1879:422
1846:PMC
1838:doi
1788:doi
1776:414
1736:doi
1732:134
1695:PMC
1687:doi
1646:PMC
1636:doi
1576:PMC
1566:doi
1506:doi
1464:doi
1460:192
1339:A–E
1279:in
1213:ATP
546:n/a
343:End
242:End
145:OMA
121:MGI
41:PDB
3968::
3765::
3709:V2
3704:V1
3694:R2
3688:R1
3683:Q2
3678:Q1
3658:L6
3653:L4
3648:L3
3643:L2
3638:L1
3628:J2
3623:J1
3608:G2
3603:G1
3598:E3
3593:E2
3588:E1
3583:D3
3578:D2
3573:D1
3405:ER
3370:14
3335:4L
3320:1L
3315:1B
3310:1A
3271:C7
3266:C6
3261:C5
3256:C3
3251:C1
3246:B9
3241:B6
3236:B4
3226:B2
3221:B1
3216:A3
3211:A2
3206:A1
3065:.
3055:.
3045:29
3043:.
3039:.
3022:.
3010:.
2993:.
2981:.
2964:.
2956:.
2946:49
2944:.
2927:.
2915:17
2913:.
2909:.
2892:.
2882:.
2872:27
2870:.
2866:.
2849:.
2839:.
2829:82
2827:.
2823:.
2806:.
2798:.
2788:.
2776:.
2758:.
2744:.
2740:.
2723:.
2709:.
2705:.
2688:.
2674:.
2670:.
2653:.
2643:.
2633:19
2631:.
2627:.
2610:.
2598:28
2596:.
2592:.
2575:.
2565:.
2551:.
2547:.
2530:.
2522:.
2512:24
2510:.
2493:.
2483:.
2471:.
2467:.
2450:.
2438:.
2420:.
2412:.
2404:.
2392:.
2375:.
2365:.
2355:.
2343:.
2339:.
2311:.
2301:20
2299:.
2275:.
2263:64
2261:.
2257:.
2234:.
2222:.
2199:.
2189:.
2181:.
2169:.
2165:.
2141:.
2131:.
2119:.
2115:.
2088:.
2076:11
2074:.
2070:.
2058:^
2044:.
2034:.
2026:.
2014:.
2010:.
1987:.
1975:17
1973:.
1969:.
1946:.
1932:.
1928:.
1905:.
1897:.
1889:.
1877:.
1854:.
1844:.
1834:24
1832:.
1828:.
1816:^
1802:.
1794:.
1786:.
1774:.
1770:.
1744:.
1730:.
1726:.
1703:.
1693:.
1683:16
1681:.
1677:.
1654:.
1644:.
1634:.
1622:.
1618:.
1598:^
1584:.
1574:.
1564:.
1552:.
1548:.
1528:^
1514:.
1502:11
1500:.
1496:.
1484:^
1470:.
1458:.
1430:^
1420:.
1402:.
1373:^
1352:^
1309:.
1268:.
1260:,
1256:,
1159:.
1134:.
726:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
3911:)
3907:(
3714:Z
3699:S
3673:O
3668:N
3663:M
3633:K
3618:I
3613:H
3568:C
3563:B
3558:A
3400:β
3394:2
3392:α
3386:1
3384:α
3360:9
3355:8
3350:7
3345:6
3340:5
3330:4
3325:2
3192:/
3164:/
3150:/
3132:e
3125:t
3118:v
3105:.
3073:.
3051::
3030:.
3018::
3001:.
2989::
2972:.
2952::
2935:.
2921::
2900:.
2878::
2857:.
2835::
2814:.
2792::
2784::
2766:.
2752::
2731:.
2717::
2696:.
2682::
2676:7
2661:.
2639::
2618:.
2604::
2583:.
2559::
2538:.
2518::
2501:.
2479::
2458:.
2446::
2428:.
2408::
2400::
2383:.
2359::
2351::
2319:.
2307::
2283:.
2269::
2242:.
2230::
2207:.
2177::
2149:.
2127::
2121:1
2096:.
2082::
2052:.
2030::
2022::
1995:.
1981::
1954:.
1940::
1913:.
1893::
1885::
1862:.
1840::
1810:.
1790::
1782::
1752:.
1738::
1711:.
1689::
1662:.
1638::
1630::
1624:7
1592:.
1568::
1560::
1554:9
1522:.
1508::
1478:.
1466::
1443:.
1424:.
1406:.
1095:(
267:)
164:)
147::
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