316:
293:
190:
215:
581:
574:
567:
322:
221:
31:
2209:
3090:
1242:
ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
1241:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
57:
1961:
Lyakhovich A, Shekhar MP (2004). "RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response".
2249:
1844:
Shekhar MP, Lyakhovich A, Visscher DW, et al. (2002). "Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation".
2502:
1594:
Woffendin C, Chen ZY, Staskus K, et al. (1991). "Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6".
329:
228:
2242:
151:
949:
930:
2235:
2847:
3159:
3135:
2188:
1335:
2133:"Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells"
1317:
3154:
2084:
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome".
315:
1165:
3065:
1668:"Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification"
1172:
292:
1405:
2258:
1304:
1283:
2458:
1355:"Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31"
1300:
214:
189:
54:
1279:
2671:
1807:
Miura T, Klaus W, Ross A, et al. (2003). "The NMR structure of the class I human ubiquitin-conjugating enzyme 2b".
131:
2616:
1251:
1920:"Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway"
328:
227:
1713:"Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens"
1470:"Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens"
321:
220:
3128:
2181:
2556:
994:
139:
2043:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
2881:
2000:"Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination"
975:
3053:
2922:
2303:
3121:
2174:
1878:
1724:
1625:"The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6"
1554:
1482:
203:
118:
1353:
Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992).
2266:
1148:
1144:
1093:
1089:
2912:
2280:
2119:
1986:
1832:
163:
2208:
1867:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1543:"Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6"
1140:
1119:
1085:
1064:
2582:
2154:
2111:
2072:
2029:
1978:
1949:
1906:
1853:
1824:
1795:
1752:
1699:
1654:
1611:
1582:
1518:
1500:
1450:
1384:
580:
573:
566:
111:
47:
3105:
2842:
2801:
2796:
2771:
2761:
2756:
2746:
2546:
2144:
2101:
2093:
2062:
2054:
2019:
2011:
1970:
1939:
1931:
1896:
1886:
1816:
1785:
1777:
1742:
1732:
1689:
1679:
1644:
1636:
1603:
1572:
1562:
1508:
1490:
1440:
1432:
1374:
1366:
408:
339:
283:
238:
2817:
2751:
159:
3048:
2271:
2106:
383:
1882:
1728:
1558:
1486:
2595:
2590:
1640:
30:
2067:
2042:
2024:
1999:
1944:
1919:
1901:
1866:
1790:
1765:
1649:
1624:
1445:
1420:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
713:
708:
703:
698:
693:
688:
683:
678:
673:
657:
652:
647:
642:
637:
632:
627:
622:
3148:
1935:
1747:
1712:
1607:
1577:
1542:
1513:
1469:
1370:
609:
1836:
3101:
2951:
2933:
2123:
1990:
401:
180:
143:
2149:
2132:
2227:
167:
3027:
2895:
1340:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1322:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2097:
484:
2857:
2285:
1820:
300:
197:
147:
2015:
1781:
1504:
1436:
2605:
2551:
1737:
1567:
1495:
894:
544:
422:
367:
354:
266:
253:
155:
2158:
2115:
2076:
2033:
1982:
1974:
1953:
1910:
1891:
1857:
1828:
1799:
1756:
1684:
1522:
1454:
1703:
1658:
1615:
1586:
1388:
1212:
1207:
2885:
2518:
2510:
1196:
1039:
1020:
2636:
2523:
2483:
2414:
2409:
2404:
2399:
2394:
2349:
2058:
1228:
1006:
961:
122:, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin conjugating enzyme E2 B
1468:
Tateishi S, Sakuraba Y, Masuyama S, Inoue H, Yamaizumi M (July 2000).
88:
84:
80:
76:
2852:
2827:
2822:
2812:
2776:
2766:
2741:
2726:
2721:
2716:
2711:
2706:
2701:
2696:
2691:
2656:
2641:
2488:
2453:
2438:
2433:
2428:
2389:
2384:
2379:
2374:
2369:
2364:
2359:
2354:
2344:
2339:
2334:
2329:
2324:
1694:
1379:
1180:
916:
3089:
1406:"Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)"
3043:
3033:
3023:
3008:
2990:
2985:
2980:
2975:
2907:
2867:
2832:
2806:
2791:
2786:
2781:
2736:
2731:
2686:
2676:
2646:
2631:
2528:
2497:
2478:
2473:
2468:
2463:
2448:
2443:
2423:
2319:
2312:
2308:
2298:
2293:
1255:
1419:
Xin H, Lin W, Sumanasekera W, Zhang Y, Wu X, Wang Z (July 2000).
879:
875:
845:
proteasome-mediated ubiquitin-dependent protein catabolic process
3097:
3058:
3038:
3018:
3013:
2963:
2946:
2902:
2890:
2872:
2862:
2661:
2651:
2626:
2621:
2566:
2561:
1666:
Koken MH, Hoogerbrugge JW, Jasper-Dekker I, et al. (1996).
1474:
1235:
135:
2231:
2170:
1667:
1354:
589:
2166:
1766:"The human RAD18 gene product interacts with HHR6A and HHR6B"
1623:
Schneider R, Eckerskorn C, Lottspeich F, Schweiger M (1990).
1421:"The human RAD18 gene product interacts with HHR6A and HHR6B"
1541:
Koken MH, Reynolds P, Jaspers-Dekker I, et al. (1991).
1865:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1998:
Watanabe K, Tateishi S, Kawasuji M, et al. (2005).
1711:
Tateishi S, Sakuraba Y, Masuyama S, et al. (2000).
391:
3109:
2041:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
765:
positive regulation of reciprocal meiotic recombination
865:
positive regulation of canonical Wnt signaling pathway
556:
3001:
2932:
2921:
2604:
2581:
2539:
2279:
2265:
1133:
1112:
1078:
1057:
1764:Xin H, Lin W, Sumanasekera W, et al. (2000).
1296:
1294:
1292:
1275:
1273:
1271:
338:
237:
18:Protein-coding gene in the species Homo sapiens
1301:GRCm38: Ensembl release 89: ENSMUSG00000020390
740:negative regulation of cAMP-mediated signaling
3129:
2243:
2182:
750:ubiquitin-dependent protein catabolic process
8:
1918:Kwon YT, Xia Z, An JY, et al. (2003).
1280:GRCh38: Ensembl release 89: ENSG00000119048
3136:
3122:
2929:
2276:
2250:
2236:
2228:
2189:
2175:
2167:
890:
605:
441:Skeletal muscle tissue of rectus abdominis
379:
278:
175:
65:
2148:
2105:
2066:
2023:
1943:
1900:
1890:
1789:
1746:
1736:
1693:
1683:
1648:
1576:
1566:
1512:
1494:
1444:
1378:
1400:
1398:
800:cellular response to DNA damage stimulus
780:negative regulation of apoptotic process
2204:
1267:
638:ubiquitin-protein transferase activity
20:
2131:Shekhar MP, Tait L, Gerard B (2007).
653:ubiquitin conjugating enzyme activity
343:
304:
299:
242:
201:
196:
7:
3086:
3084:
499:medial head of gastrocnemius muscle
3108:. You can help Knowledge (XXG) by
3066:Prokaryotic ubiquitin-like protein
1641:10.1002/j.1460-2075.1990.tb08259.x
1130:
1109:
1075:
1054:
1030:
1011:
985:
966:
940:
921:
820:regulation of histone modification
561:
479:
417:
396:
14:
1231:that in humans is encoded by the
1225:Ubiquitin-conjugating enzyme E2 B
835:synaptonemal complex organization
815:protein K48-linked ubiquitination
805:protein K11-linked ubiquitination
755:protein K63-linked ubiquitination
633:ubiquitin protein ligase activity
3088:
2207:
1936:10.1128/MCB.23.22.8255-8271.2003
658:ubiquitin protein ligase binding
579:
572:
565:
327:
320:
314:
291:
226:
219:
213:
188:
29:
830:canonical Wnt signaling pathway
2596:Mitochondrial targeting signal
2259:Posttranslational modification
2107:11858/00-001M-0000-0010-8592-0
1481:(14). UNITED STATES: 7927β32.
785:in utero embryonic development
590:More reference expression data
545:More reference expression data
1:
3160:Human chromosome 5 gene stubs
2150:10.1158/1541-7786.MCR-06-0136
1475:Proc. Natl. Acad. Sci. U.S.A.
312:
211:
2672:Ubiquitin-conjugating enzyme
1871:Proc. Natl. Acad. Sci. U.S.A
1717:Proc. Natl. Acad. Sci. U.S.A
1608:10.1016/0167-4781(91)90039-o
1547:Proc. Natl. Acad. Sci. U.S.A
1371:10.1016/0888-7543(92)90433-S
810:histone lysine demethylation
3155:Genes on human chromosome 5
2960:E2 SUMO-conjugating enzyme
2617:Ubiquitin-activating enzyme
760:meiotic telomere clustering
3176:
3083:
2943:E1 SUMO-activating enzyme
2098:10.1016/j.cell.2005.08.029
850:protein autoubiquitination
790:protein monoubiquitination
775:protein polyubiquitination
735:histone H2A ubiquitination
519:sternocleidomastoid muscle
2202:
1336:"Mouse PubMed Reference:"
1318:"Human PubMed Reference:"
1211:
1206:
1202:
1195:
1179:
1166:Chr 5: 134.37 β 134.39 Mb
1160:
1137:
1116:
1105:
1082:
1061:
1050:
1037:
1033:
1018:
1014:
1005:
992:
988:
973:
969:
960:
947:
943:
928:
924:
915:
900:
893:
889:
873:
608:
604:
587:
564:
555:
542:
507:quadriceps femoris muscle
491:
482:
461:Descending thoracic aorta
429:
420:
390:
382:
378:
361:
348:
311:
290:
281:
277:
260:
247:
210:
187:
178:
174:
129:
126:
116:
109:
104:
73:
68:
51:
46:
41:
37:
28:
23:
2557:Survival of motor neuron
2016:10.1038/sj.emboj.7600383
1431:(14). ENGLAND: 2847β54.
1250:UBE2B has been shown to
1173:Chr 11: 51.88 β 51.89 Mb
2923:Ubiquitin-like proteins
2882:Deubiquitinating enzyme
1821:10.1023/A:1013807519703
1738:10.1073/pnas.97.14.7927
1568:10.1073/pnas.88.20.8865
1496:10.1073/pnas.97.14.7927
515:vastus lateralis muscle
1975:10.1038/sj.onc.1207449
1892:10.1073/pnas.242603899
1782:10.1093/nar/28.14.2847
1685:10.1006/dbio.1996.0011
1596:Biochim. Biophys. Acta
1437:10.1093/nar/28.14.2847
860:protein ubiquitination
795:sperm axoneme assembly
745:postreplication repair
527:atrioventricular valve
511:triceps brachii muscle
770:protein stabilization
306:Chromosome 11 (mouse)
623:transferase activity
437:gastrocnemius muscle
204:Chromosome 5 (human)
69:List of PDB id codes
42:Available structures
2281:Heat shock proteins
1883:2002PNAS...9916899M
1729:2000PNAS...97.7927T
1559:1991PNAS...88.8865K
1487:2000PNAS...97.7927T
469:ganglionic eminence
3096:This article on a
2059:10.1101/gr.2596504
995:ENSMUSG00000020390
723:Biological process
667:Cellular component
628:nucleotide binding
616:Molecular function
495:intercostal muscle
465:anterior pituitary
3117:
3116:
3078:
3077:
3074:
3073:
2583:Protein targeting
2577:
2576:
2225:
2224:
1877:(26): 16899β903.
1770:Nucleic Acids Res
1425:Nucleic Acids Res
1222:
1221:
1218:
1217:
1191:
1190:
1156:
1155:
1127:
1126:
1101:
1100:
1072:
1071:
1046:
1045:
1027:
1026:
1001:
1000:
982:
981:
956:
955:
937:
936:
885:
884:
600:
599:
596:
595:
551:
550:
538:
537:
476:
475:
374:
373:
273:
272:
168:UBE2B - orthologs
100:
99:
96:
95:
52:Ortholog search:
3167:
3138:
3131:
3124:
3092:
3085:
2930:
2843:Ubiquitin ligase
2609:(ubiquitylation)
2547:Alpha crystallin
2277:
2252:
2245:
2238:
2229:
2211:
2191:
2184:
2177:
2168:
2162:
2152:
2127:
2109:
2080:
2070:
2037:
2027:
1994:
1969:(17): 3097β106.
1957:
1947:
1914:
1904:
1894:
1861:
1840:
1803:
1793:
1760:
1750:
1740:
1707:
1697:
1687:
1662:
1652:
1619:
1590:
1580:
1570:
1527:
1526:
1516:
1498:
1465:
1459:
1458:
1448:
1416:
1410:
1409:
1402:
1393:
1392:
1382:
1350:
1344:
1343:
1332:
1326:
1325:
1314:
1308:
1298:
1287:
1277:
1204:
1203:
1175:
1168:
1151:
1131:
1122:
1110:
1106:RefSeq (protein)
1096:
1076:
1067:
1055:
1031:
1012:
986:
967:
941:
922:
891:
730:chiasma assembly
689:replication fork
606:
592:
583:
576:
569:
562:
547:
487:
485:Top expressed in
480:
457:body of pancreas
425:
423:Top expressed in
418:
397:
380:
370:
357:
346:
331:
324:
318:
307:
295:
279:
269:
256:
245:
230:
223:
217:
206:
192:
176:
170:
121:
114:
91:
66:
60:
39:
38:
33:
21:
3175:
3174:
3170:
3169:
3168:
3166:
3165:
3164:
3145:
3144:
3143:
3142:
3081:
3079:
3070:
2997:
2972:E3 SUMO ligase
2936:
2925:
2917:
2608:
2600:
2573:
2535:
2514:
2506:
2284:
2272:protein folding
2270:
2261:
2256:
2226:
2221:
2218:
2212:
2198:
2195:
2165:
2137:Mol. Cancer Res
2130:
2083:
2053:(10B): 2121β7.
2040:
2010:(19): 3886β96.
1997:
1960:
1930:(22): 8255β71.
1924:Mol. Cell. Biol
1917:
1864:
1843:
1806:
1776:(14): 2847β54.
1763:
1723:(14): 7927β32.
1710:
1665:
1622:
1593:
1540:
1536:
1534:Further reading
1531:
1530:
1467:
1466:
1462:
1418:
1417:
1413:
1404:
1403:
1396:
1352:
1351:
1347:
1334:
1333:
1329:
1316:
1315:
1311:
1299:
1290:
1278:
1269:
1264:
1248:
1213:View/Edit Mouse
1208:View/Edit Human
1171:
1164:
1161:Location (UCSC)
1147:
1143:
1139:
1118:
1092:
1088:
1084:
1063:
976:ENSG00000119048
869:
825:spermatogenesis
718:
684:plasma membrane
662:
643:protein binding
588:
578:
577:
571:
570:
543:
534:
531:arcuate nucleus
529:
525:
523:temporal muscle
521:
517:
513:
509:
505:
503:muscle of thigh
501:
497:
483:
472:
467:
463:
459:
455:
451:
447:
443:
439:
435:
433:muscle of thigh
421:
365:
352:
345:11|11 B1.3
344:
334:
333:
332:
325:
305:
282:Gene location (
264:
251:
243:
233:
232:
231:
224:
202:
179:Gene location (
130:
117:
110:
75:
53:
19:
12:
11:
5:
3173:
3171:
3163:
3162:
3157:
3147:
3146:
3141:
3140:
3133:
3126:
3118:
3115:
3114:
3093:
3076:
3075:
3072:
3071:
3069:
3068:
3062:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3021:
3016:
3011:
3005:
3003:
2999:
2998:
2996:
2995:
2994:
2993:
2988:
2983:
2978:
2969:
2968:
2967:
2966:
2957:
2956:
2955:
2954:
2949:
2940:
2938:
2927:
2919:
2918:
2916:
2915:
2910:
2905:
2899:
2898:
2893:
2888:
2878:
2877:
2876:
2875:
2870:
2865:
2860:
2855:
2850:
2838:
2837:
2836:
2835:
2830:
2825:
2820:
2815:
2810:
2804:
2799:
2794:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2667:
2666:
2665:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2629:
2624:
2612:
2610:
2602:
2601:
2599:
2598:
2593:
2591:Signal peptide
2587:
2585:
2579:
2578:
2575:
2574:
2572:
2571:
2570:
2569:
2564:
2554:
2549:
2543:
2541:
2537:
2536:
2534:
2533:
2532:
2531:
2526:
2521:
2516:
2512:
2508:
2504:
2494:
2493:
2492:
2491:
2486:
2481:
2476:
2471:
2466:
2461:
2456:
2451:
2446:
2441:
2436:
2431:
2420:
2419:
2418:
2417:
2412:
2407:
2402:
2397:
2392:
2387:
2382:
2377:
2372:
2367:
2362:
2357:
2352:
2347:
2342:
2337:
2332:
2327:
2316:
2315:
2306:
2301:
2296:
2290:
2288:
2274:
2263:
2262:
2257:
2255:
2254:
2247:
2240:
2232:
2223:
2222:
2220:
2219:
2213:
2206:
2203:
2200:
2199:
2196:
2194:
2193:
2186:
2179:
2171:
2164:
2163:
2143:(10): 729β45.
2128:
2081:
2038:
1995:
1958:
1915:
1862:
1852:(7): 2115β24.
1841:
1809:J. Biomol. NMR
1804:
1761:
1708:
1663:
1620:
1591:
1553:(20): 8865β9.
1537:
1535:
1532:
1529:
1528:
1460:
1411:
1394:
1345:
1327:
1309:
1288:
1266:
1265:
1263:
1260:
1247:
1244:
1220:
1219:
1216:
1215:
1210:
1200:
1199:
1193:
1192:
1189:
1188:
1186:
1184:
1177:
1176:
1169:
1162:
1158:
1157:
1154:
1153:
1135:
1134:
1128:
1125:
1124:
1114:
1113:
1107:
1103:
1102:
1099:
1098:
1080:
1079:
1073:
1070:
1069:
1059:
1058:
1052:
1048:
1047:
1044:
1043:
1035:
1034:
1028:
1025:
1024:
1016:
1015:
1009:
1003:
1002:
999:
998:
990:
989:
983:
980:
979:
971:
970:
964:
958:
957:
954:
953:
945:
944:
938:
935:
934:
926:
925:
919:
913:
912:
907:
902:
898:
897:
887:
886:
883:
882:
871:
870:
868:
867:
862:
857:
852:
847:
842:
840:response to UV
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
726:
724:
720:
719:
717:
716:
711:
706:
701:
696:
691:
686:
681:
676:
670:
668:
664:
663:
661:
660:
655:
650:
645:
640:
635:
630:
625:
619:
617:
613:
612:
602:
601:
598:
597:
594:
593:
585:
584:
559:
553:
552:
549:
548:
540:
539:
536:
535:
533:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
489:
488:
477:
474:
473:
471:
470:
466:
462:
458:
454:
453:biceps brachii
450:
446:
442:
438:
434:
430:
427:
426:
414:
413:
405:
394:
388:
387:
384:RNA expression
376:
375:
372:
371:
363:
359:
358:
350:
347:
342:
336:
335:
326:
319:
313:
309:
308:
303:
297:
296:
288:
287:
275:
274:
271:
270:
262:
258:
257:
249:
246:
241:
235:
234:
225:
218:
212:
208:
207:
200:
194:
193:
185:
184:
172:
171:
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3172:
3161:
3158:
3156:
3153:
3152:
3150:
3139:
3134:
3132:
3127:
3125:
3120:
3119:
3113:
3111:
3107:
3103:
3099:
3094:
3091:
3087:
3082:
3067:
3064:
3063:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3029:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3006:
3004:
3000:
2992:
2989:
2987:
2984:
2982:
2979:
2977:
2974:
2973:
2971:
2970:
2965:
2962:
2961:
2959:
2958:
2953:
2950:
2948:
2945:
2944:
2942:
2941:
2939:
2937:(SUMOylation)
2935:
2931:
2928:
2924:
2920:
2914:
2911:
2909:
2906:
2904:
2901:
2900:
2897:
2894:
2892:
2889:
2887:
2883:
2880:
2879:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2845:
2844:
2840:
2839:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2674:
2673:
2669:
2668:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2619:
2618:
2614:
2613:
2611:
2607:
2603:
2597:
2594:
2592:
2589:
2588:
2586:
2584:
2580:
2568:
2565:
2563:
2560:
2559:
2558:
2555:
2553:
2550:
2548:
2545:
2544:
2542:
2538:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2509:
2507:
2501:
2500:
2499:
2496:
2495:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2426:
2425:
2422:
2421:
2416:
2413:
2411:
2408:
2406:
2403:
2401:
2398:
2396:
2393:
2391:
2388:
2386:
2383:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2322:
2321:
2318:
2317:
2314:
2310:
2307:
2305:
2302:
2300:
2297:
2295:
2292:
2291:
2289:
2287:
2282:
2278:
2275:
2273:
2268:
2264:
2260:
2253:
2248:
2246:
2241:
2239:
2234:
2233:
2230:
2216:
2210:
2205:
2201:
2192:
2187:
2185:
2180:
2178:
2173:
2172:
2169:
2160:
2156:
2151:
2146:
2142:
2138:
2134:
2129:
2125:
2121:
2117:
2113:
2108:
2103:
2099:
2095:
2092:(6): 957β68.
2091:
2087:
2082:
2078:
2074:
2069:
2064:
2060:
2056:
2052:
2048:
2044:
2039:
2035:
2031:
2026:
2021:
2017:
2013:
2009:
2005:
2001:
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1964:
1959:
1955:
1951:
1946:
1941:
1937:
1933:
1929:
1925:
1921:
1916:
1912:
1908:
1903:
1898:
1893:
1888:
1884:
1880:
1876:
1872:
1868:
1863:
1859:
1855:
1851:
1847:
1842:
1838:
1834:
1830:
1826:
1822:
1818:
1814:
1810:
1805:
1801:
1797:
1792:
1787:
1783:
1779:
1775:
1771:
1767:
1762:
1758:
1754:
1749:
1744:
1739:
1734:
1730:
1726:
1722:
1718:
1714:
1709:
1705:
1701:
1696:
1691:
1686:
1681:
1678:(1): 119β32.
1677:
1673:
1669:
1664:
1660:
1656:
1651:
1646:
1642:
1638:
1635:(5): 1431β5.
1634:
1630:
1626:
1621:
1617:
1613:
1609:
1605:
1601:
1597:
1592:
1588:
1584:
1579:
1574:
1569:
1564:
1560:
1556:
1552:
1548:
1544:
1539:
1538:
1533:
1524:
1520:
1515:
1510:
1506:
1502:
1497:
1492:
1488:
1484:
1480:
1477:
1476:
1471:
1464:
1461:
1456:
1452:
1447:
1442:
1438:
1434:
1430:
1426:
1422:
1415:
1412:
1407:
1401:
1399:
1395:
1390:
1386:
1381:
1376:
1372:
1368:
1365:(3): 447β53.
1364:
1360:
1356:
1349:
1346:
1341:
1337:
1331:
1328:
1323:
1319:
1313:
1310:
1306:
1302:
1297:
1295:
1293:
1289:
1285:
1281:
1276:
1274:
1272:
1268:
1261:
1259:
1257:
1253:
1245:
1243:
1239:
1237:
1234:
1230:
1226:
1214:
1209:
1205:
1201:
1198:
1194:
1187:
1185:
1182:
1178:
1174:
1170:
1167:
1163:
1159:
1152:
1150:
1146:
1142:
1136:
1132:
1129:
1123:
1121:
1115:
1111:
1108:
1104:
1097:
1095:
1091:
1087:
1081:
1077:
1074:
1068:
1066:
1060:
1056:
1053:
1051:RefSeq (mRNA)
1049:
1042:
1041:
1036:
1032:
1029:
1023:
1022:
1017:
1013:
1010:
1008:
1004:
997:
996:
991:
987:
984:
978:
977:
972:
968:
965:
963:
959:
952:
951:
946:
942:
939:
933:
932:
927:
923:
920:
918:
914:
911:
908:
906:
903:
899:
896:
892:
888:
881:
877:
872:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
727:
725:
722:
721:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
671:
669:
666:
665:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
620:
618:
615:
614:
611:
610:Gene ontology
607:
603:
591:
586:
582:
575:
568:
563:
560:
558:
554:
546:
541:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
493:
490:
486:
481:
478:
468:
464:
460:
456:
452:
449:right auricle
448:
444:
440:
436:
432:
431:
428:
424:
419:
416:
415:
412:
410:
406:
404:
403:
399:
398:
395:
393:
389:
385:
381:
377:
369:
364:
360:
356:
351:
341:
337:
330:
323:
317:
310:
302:
298:
294:
289:
285:
280:
276:
268:
263:
259:
255:
250:
240:
236:
229:
222:
216:
209:
205:
199:
195:
191:
186:
182:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
3110:expanding it
3102:chromosome 5
3095:
3080:
2934:SUMO protein
2681:
2214:
2140:
2136:
2089:
2085:
2050:
2046:
2007:
2003:
1966:
1962:
1927:
1923:
1874:
1870:
1849:
1845:
1815:(1): 89β92.
1812:
1808:
1773:
1769:
1720:
1716:
1675:
1671:
1632:
1628:
1599:
1595:
1550:
1546:
1478:
1473:
1463:
1428:
1424:
1414:
1362:
1358:
1348:
1339:
1330:
1321:
1312:
1249:
1246:Interactions
1240:
1232:
1224:
1223:
1149:NP_001349615
1145:NP_001349614
1138:
1117:
1094:NM_001362686
1090:NM_001362685
1083:
1062:
1038:
1019:
993:
974:
948:
929:
909:
904:
694:HULC complex
407:
400:
265:134,392,108
252:134,371,184
127:External IDs
74:
15:
3028:neddylation
2294:Hsp10/GroES
2286:Chaperonins
2197:PDB gallery
1602:(1): 81β5.
699:nucleoplasm
648:ATP binding
366:51,891,589
353:51,876,324
105:Identifiers
3149:Categories
2320:Hsp40/DnaJ
2267:Chaperones
2047:Genome Res
1846:Cancer Res
1307:, May 2017
1286:, May 2017
1262:References
855:DNA repair
445:right lung
411:(ortholog)
148:HomoloGene
3100:on human
2606:Ubiquitin
2552:Clusterin
2217:: HsUbc2b
1695:1765/3093
1672:Dev. Biol
1505:0027-8424
1380:1765/3036
1141:NP_033484
1120:NP_003328
1086:NM_009458
1065:NM_003337
895:Orthologs
709:chromatin
674:cytoplasm
156:GeneCards
2886:Ataxin 3
2159:17050667
2116:16169070
2077:15489334
2034:15359278
1983:14981545
1963:Oncogene
1954:14585983
1911:12477932
1858:11929833
1837:27799378
1829:11885984
1800:10908344
1757:10884424
1523:10884424
1455:10908344
1359:Genomics
1303:–
1282:–
1252:interact
1197:Wikidata
874:Sources:
679:membrane
2809:(CDC34)
2124:8235923
1991:6180818
1879:Bibcode
1725:Bibcode
1704:8575614
1659:2158443
1616:1883845
1587:1717990
1555:Bibcode
1483:Bibcode
1389:1559696
1305:Ensembl
1284:Ensembl
1229:protein
1007:UniProt
962:Ensembl
901:Species
880:QuickGO
714:nucleus
704:XY body
386:pattern
112:Aliases
2853:Cullin
2157:
2122:
2114:
2075:
2068:528928
2065:
2032:
2025:522788
2022:
2004:EMBO J
1989:
1981:
1952:
1945:262401
1942:
1909:
1902:139241
1899:
1856:
1835:
1827:
1798:
1791:102657
1788:
1755:
1745:
1702:
1657:
1650:551831
1647:
1629:EMBO J
1614:
1585:
1575:
1521:
1511:
1503:
1453:
1446:102657
1443:
1387:
1183:search
1181:PubMed
1040:P63147
1021:P63146
917:Entrez
557:BioGPS
244:5q31.1
152:101298
144:102944
136:179095
3104:is a
3044:ATG12
3034:FAT10
3024:NEDD8
3009:ISG15
3002:Other
2991:PIAS4
2986:PIAS3
2981:PIAS2
2976:PIAS1
2926:(UBL)
2908:BIRC6
2868:FANCL
2540:Other
2529:TRAP1
2498:Hsp90
2424:Hsp70
2313:GroEL
2309:HSP60
2304:Hsp47
2299:Hsp27
2120:S2CID
1987:S2CID
1833:S2CID
1748:16647
1578:52611
1514:16647
1256:RAD18
1254:with
1233:UBE2B
1227:is a
950:22210
910:Mouse
905:Human
876:Amigo
409:Mouse
402:Human
349:Start
284:Mouse
248:Start
181:Human
160:UBE2B
119:UBE2B
24:UBE2B
3106:stub
3098:gene
3059:UBL5
3049:FUB1
3039:ATG8
3019:UFM1
3014:URM1
2964:UBC9
2952:SAE2
2947:SAE1
2913:UFC1
2903:ATG3
2896:CYLD
2891:USP6
2873:UBR1
2863:MDM2
2662:SAE1
2657:NAE1
2652:ATG7
2647:UBA7
2642:UBA6
2637:UBA5
2632:UBA3
2627:UBA2
2622:UBA1
2567:SMN2
2562:SMN1
2215:1jas
2155:PMID
2112:PMID
2086:Cell
2073:PMID
2030:PMID
1979:PMID
1950:PMID
1907:PMID
1854:PMID
1825:PMID
1796:PMID
1753:PMID
1700:PMID
1655:PMID
1612:PMID
1600:1090
1583:PMID
1519:PMID
1501:ISSN
1451:PMID
1385:PMID
1236:gene
931:7320
392:Bgee
340:Band
301:Chr.
239:Band
198:Chr.
132:OMIM
89:2YBF
85:2YB6
81:2Y4W
77:1JAS
58:RCSB
55:PDBe
3054:MUB
2858:CBL
2848:VHL
2841:E3
2670:E2
2615:E1
2484:12A
2415:C19
2410:C14
2405:C13
2400:C11
2395:C10
2350:B11
2145:doi
2102:hdl
2094:doi
2090:122
2063:PMC
2055:doi
2020:PMC
2012:doi
1971:doi
1940:PMC
1932:doi
1897:PMC
1887:doi
1817:doi
1786:PMC
1778:doi
1743:PMC
1733:doi
1690:hdl
1680:doi
1676:173
1645:PMC
1637:doi
1604:doi
1573:PMC
1563:doi
1509:PMC
1491:doi
1441:PMC
1433:doi
1375:hdl
1367:doi
362:End
261:End
164:OMA
140:MGI
48:PDB
3151::
2884::
2828:V2
2823:V1
2813:R2
2807:R1
2802:Q2
2797:Q1
2777:L6
2772:L4
2767:L3
2762:L2
2757:L1
2747:J2
2742:J1
2727:G2
2722:G1
2717:E3
2712:E2
2707:E1
2702:D3
2697:D2
2692:D1
2524:ER
2489:14
2454:4L
2439:1L
2434:1B
2429:1A
2390:C7
2385:C6
2380:C5
2375:C3
2370:C1
2365:B9
2360:B6
2355:B4
2345:B2
2340:B1
2335:A3
2330:A2
2325:A1
2153:.
2139:.
2135:.
2118:.
2110:.
2100:.
2088:.
2071:.
2061:.
2051:14
2049:.
2045:.
2028:.
2018:.
2008:23
2006:.
2002:.
1985:.
1977:.
1967:23
1965:.
1948:.
1938:.
1928:23
1926:.
1922:.
1905:.
1895:.
1885:.
1875:99
1873:.
1869:.
1850:62
1848:.
1831:.
1823:.
1813:22
1811:.
1794:.
1784:.
1774:28
1772:.
1768:.
1751:.
1741:.
1731:.
1721:97
1719:.
1715:.
1698:.
1688:.
1674:.
1670:.
1653:.
1643:.
1631:.
1627:.
1610:.
1598:.
1581:.
1571:.
1561:.
1551:88
1549:.
1545:.
1517:.
1507:.
1499:.
1489:.
1479:97
1472:.
1449:.
1439:.
1429:28
1427:.
1423:.
1397:^
1383:.
1373:.
1363:12
1361:.
1357:.
1338:.
1320:.
1291:^
1270:^
1258:.
1238:.
878:/
368:bp
355:bp
267:bp
254:bp
162:;
158::
154:;
150::
146:;
142::
138:;
134::
87:,
83:,
79:,
3137:e
3130:t
3123:v
3112:.
3030:)
3026:(
2833:Z
2818:S
2792:O
2787:N
2782:M
2752:K
2737:I
2732:H
2687:C
2682:B
2677:A
2519:Ξ²
2513:2
2511:Ξ±
2505:1
2503:Ξ±
2479:9
2474:8
2469:7
2464:6
2459:5
2449:4
2444:2
2311:/
2283:/
2269:/
2251:e
2244:t
2237:v
2190:e
2183:t
2176:v
2161:.
2147::
2141:4
2126:.
2104::
2096::
2079:.
2057::
2036:.
2014::
1993:.
1973::
1956:.
1934::
1913:.
1889::
1881::
1860:.
1839:.
1819::
1802:.
1780::
1759:.
1735::
1727::
1706:.
1692::
1682::
1661:.
1639::
1633:9
1618:.
1606::
1589:.
1565::
1557::
1525:.
1493::
1485::
1457:.
1435::
1408:.
1391:.
1377::
1369::
1342:.
1324:.
286:)
183:)
166::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
