426:
403:
2362:
300:
325:
691:
684:
677:
2332:
2437:
2422:
2407:
2377:
2392:
2452:
2317:
31:
432:
331:
2347:
3333:
1249:
ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
1248:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
57:
1913:
Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, Glass S, Parsons T, Copeland RA, Auger KR, Benfield P, Brizuela L, Rolfe M (Jul 2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4".
1768:
Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes".
1492:
Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes".
2215:
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region".
2361:
2107:
Xu L, Yang L, Moitra PK, Hashimoto K, Rallabhandi P, Kaul S, Meroni G, Jensen JP, Weissman AM, D'Arpa P (Aug 2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta".
2492:
2745:
1841:
Joazeiro CA, Wing SS, Huang H, Leverson JD, Hunter T, Liu YC (Oct 1999). "The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase".
2245:
Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (Mar 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair".
439:
338:
1629:"Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)"
2485:
1266:
2331:
959:
2436:
2421:
2406:
2376:
940:
247:
2370:: The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance
2478:
2391:
3090:
2451:
3402:
2316:
3378:
2296:
1372:
1953:"The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum"
1354:
3397:
1808:"Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha"
425:
1167:
3308:
1174:
402:
1450:"Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment"
1434:
1735:"Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases"
1541:"Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases"
2501:
1341:
1320:
2701:
1337:
324:
299:
54:
1316:
2914:
227:
2859:
1258:
438:
337:
2074:"The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity"
2346:
2006:"PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain"
1585:"PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain"
431:
330:
3371:
2289:
1682:"Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53"
2799:
1004:
271:
235:
1806:
Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A (May 1999).
3124:
985:
3296:
3165:
2546:
2137:
Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (Oct 2003).
3364:
2282:
2039:"Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein"
1964:
1693:
1640:
313:
214:
2509:
1627:
Rolfe M, Beer-Romero P, Glass S, Eckstein J, Berdo I, Theodoras A, Pagano M, Draetta G (Apr 1995).
3155:
2523:
2139:"The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase"
1939:
1794:
1518:
259:
1150:
1129:
1125:
1099:
1078:
1074:
690:
2825:
2262:
2233:
2203:
2168:
2125:
2095:
2060:
2025:
1992:
1931:
1901:
1858:
1829:
1786:
1756:
1721:
1668:
1604:
1562:
1510:
1471:
1413:
207:
47:
3348:
3085:
3044:
3039:
3014:
3004:
2999:
2989:
2789:
2254:
2225:
2193:
2158:
2150:
2117:
2085:
2050:
2017:
1982:
1972:
1923:
1891:
1883:
1850:
1819:
1778:
1746:
1711:
1701:
1658:
1648:
1596:
1552:
1502:
1461:
1403:
683:
676:
518:
449:
393:
348:
255:
3060:
2994:
1448:
Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL (Nov 2008).
277:
3291:
2514:
1872:"Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome"
493:
2072:
Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (Jun 2003).
1968:
1697:
1644:
30:
2838:
2833:
2163:
2138:
2229:
2121:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
798:
793:
788:
783:
778:
762:
757:
752:
747:
742:
737:
732:
3391:
1987:
1952:
1896:
1887:
1871:
1782:
1716:
1681:
1663:
1628:
1506:
719:
1943:
239:
3344:
3194:
3176:
1798:
1522:
1392:"Identification of a family of closely related human ubiquitin conjugating enzymes"
511:
290:
218:, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2
845:
regulation of transcription from RNA polymerase II promoter in response to hypoxia
2470:
1854:
263:
3270:
3138:
2182:"CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival"
1435:"Entrez Gene: UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)"
1377:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1359:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1957:
Proceedings of the
National Academy of Sciences of the United States of America
1686:
Proceedings of the
National Academy of Sciences of the United States of America
1633:
Proceedings of the
National Academy of Sciences of the United States of America
594:
3100:
2528:
2258:
410:
307:
243:
1824:
1807:
1751:
1734:
1557:
1540:
1408:
1391:
2848:
2794:
1706:
904:
654:
532:
477:
464:
376:
363:
251:
2266:
2237:
2207:
2198:
2181:
2172:
2154:
2129:
2099:
2090:
2073:
2064:
2055:
2038:
2029:
2021:
1996:
1977:
1935:
1927:
1905:
1862:
1833:
1653:
1608:
1600:
1475:
1466:
1449:
1790:
1760:
1725:
1672:
1566:
1514:
1417:
1214:
1209:
3128:
2761:
2753:
1198:
1049:
1030:
1951:
Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM (Dec 2001).
2879:
2766:
2726:
2657:
2652:
2647:
2642:
2637:
2592:
1230:
1016:
971:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
3095:
3070:
3065:
3055:
3019:
3009:
2984:
2969:
2964:
2959:
2954:
2949:
2944:
2934:
2899:
2884:
2731:
2696:
2681:
2676:
2671:
2632:
2627:
2622:
2617:
2612:
2607:
2602:
2597:
2587:
2582:
2577:
2572:
2567:
1182:
926:
3332:
2005:
1584:
2340:: NMR SOLUTION STRUCTURE OF THE UBIQUITIN CONJUGATING ENZYME UBCH5B
3286:
3276:
3266:
3251:
3233:
3228:
3223:
3218:
3150:
3110:
3075:
3049:
3034:
3029:
3024:
2979:
2974:
2929:
2924:
2919:
2889:
2874:
2771:
2740:
2721:
2716:
2711:
2706:
2691:
2686:
2666:
2562:
2555:
2551:
2541:
2536:
1390:
Jensen JP, Bates PW, Yang M, Vierstra RD, Weissman AM (Dec 1995).
1290:
1272:
889:
885:
3340:
3301:
3281:
3261:
3256:
3206:
3189:
3145:
3133:
3115:
3105:
2904:
2894:
2869:
2864:
2809:
2804:
2445:: Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ser94Gly
2430:: Human ubiquitin-conjugating enzyme (E2) UbcH5b mutant Ile88Ala
2415:: Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ile37Ala
2385:: CRYSTAL STRUCTURE OF HUMAN UBIQUITIN-CONJUGATING ENZYME UBCH5B
1284:
1278:
1237:
231:
2474:
2278:
1870:
Tongaonkar P, Chen L, Lambertson D, Ko B, Madura K (Jul 2000).
699:
2274:
2400:: Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b, wild-type
2460:: Solution Structure of the UbcH5c/Ub Non-covalent Complex
2325:: NMR BASED STRUCTURAL MODEL OF THE UBCH5B-CNOT4 COMPLEX
501:
3352:
2037:
Xia Y, Pao GM, Chen HW, Verma IM, Hunter T (Feb 2003).
865:
MyD88-independent toll-like receptor signaling pathway
2180:
Shimura H, Schwartz D, Gygi SP, Kosik KS (Feb 2004).
666:
825:
stimulatory C-type lectin receptor signaling pathway
3244:
3175:
3164:
2847:
2824:
2782:
2522:
2508:
1143:
1118:
1092:
1067:
830:
TRIF-dependent toll-like receptor signaling pathway
1680:Scheffner M, Huibregtse JM, Howley PM (Sep 1994).
1333:
1331:
1329:
1312:
1310:
1308:
1733:Hatakeyama S, Jensen JP, Weissman AM (Jun 1997).
1539:Hatakeyama S, Jensen JP, Weissman AM (Jun 1997).
448:
347:
1578:
1576:
18:Protein-coding gene in the species Homo sapiens
1338:GRCm38: Ensembl release 89: ENSMUSG00000091896
3372:
2486:
2290:
1534:
1532:
1487:
1485:
815:ubiquitin-dependent protein catabolic process
8:
1317:GRCh38: Ensembl release 89: ENSG00000131508
1267:Baculoviral IAP repeat-containing protein 3
3379:
3365:
3172:
2519:
2493:
2479:
2471:
2297:
2283:
2275:
2004:Yu P, Chen Y, Tagle DA, Cai T (Jun 2002).
1583:Yu P, Chen Y, Tagle DA, Cai T (Jun 2002).
900:
715:
489:
388:
285:
65:
2197:
2162:
2089:
2054:
1986:
1976:
1895:
1823:
1750:
1715:
1705:
1662:
1652:
1556:
1465:
1407:
1429:
1427:
2312:
1304:
629:paraventricular nucleus of hypothalamus
743:ubiquitin-protein transferase activity
20:
835:Fc-epsilon receptor signaling pathway
758:ubiquitin conjugating enzyme activity
453:
414:
409:
352:
311:
306:
7:
3329:
3327:
2186:The Journal of Biological Chemistry
2078:The Journal of Biological Chemistry
2043:The Journal of Biological Chemistry
1812:The Journal of Biological Chemistry
1739:The Journal of Biological Chemistry
1545:The Journal of Biological Chemistry
1454:The Journal of Biological Chemistry
1396:The Journal of Biological Chemistry
3351:. You can help Knowledge (XXG) by
3309:Prokaryotic ubiquitin-like protein
1227:Ubiquitin-conjugating enzyme E2 D2
1140:
1115:
1089:
1064:
1040:
1021:
995:
976:
950:
931:
671:
589:
527:
506:
14:
1233:that in humans is encoded by the
875:protein K11-linked ubiquitination
850:T cell receptor signaling pathway
840:protein K48-linked ubiquitination
3331:
2450:
2435:
2420:
2405:
2390:
2375:
2360:
2345:
2330:
2315:
1888:10.1128/MCB.20.13.4691-4698.2000
1783:10.1046/j.1365-2443.1998.00227.x
1507:10.1046/j.1365-2443.1998.00227.x
763:ubiquitin protein ligase binding
689:
682:
675:
617:dorsomedial hypothalamic nucleus
437:
430:
424:
401:
336:
329:
323:
298:
29:
870:protein targeting to peroxisome
2839:Mitochondrial targeting signal
2502:Posttranslational modification
1876:Molecular and Cellular Biology
700:More reference expression data
655:More reference expression data
1:
3403:Human chromosome 5 gene stubs
2355:: Crystal structure of ubch5c
2230:10.1016/S0888-7543(03)00235-0
2122:10.1016/S0014-4827(03)00187-3
422:
321:
2915:Ubiquitin-conjugating enzyme
2247:Journal of Molecular Biology
1855:10.1126/science.286.5438.309
3398:Genes on human chromosome 5
3203:E2 SUMO-conjugating enzyme
2860:Ubiquitin-activating enzyme
3419:
3326:
3186:E1 SUMO-activating enzyme
2110:Experimental Cell Research
855:protein autoubiquitination
820:protein polyubiquitination
799:protein-containing complex
2310:
2259:10.1016/j.jmb.2004.01.031
2143:British Journal of Cancer
1373:"Mouse PubMed Reference:"
1355:"Human PubMed Reference:"
1257:UBE2D2 has been shown to
1213:
1208:
1204:
1197:
1181:
1168:Chr 5: 139.53 β 139.63 Mb
1162:
1147:
1122:
1111:
1096:
1071:
1060:
1047:
1043:
1028:
1024:
1015:
1002:
998:
983:
979:
970:
957:
953:
938:
934:
925:
910:
903:
899:
883:
718:
714:
697:
674:
665:
652:
601:
592:
539:
530:
500:
492:
488:
471:
458:
421:
400:
391:
387:
370:
357:
320:
297:
288:
284:
275:
270:
225:
222:
212:
205:
200:
73:
68:
51:
46:
41:
37:
28:
23:
2800:Survival of motor neuron
1825:10.1074/jbc.274.21.14823
1752:10.1074/jbc.272.24.15085
1558:10.1074/jbc.272.24.15085
1409:10.1074/jbc.270.51.30408
784:ubiquitin ligase complex
641:dorsal tegmental nucleus
3166:Ubiquitin-like proteins
3125:Deubiquitinating enzyme
1707:10.1073/pnas.91.19.8797
1175:Chr 18: 35.9 β 35.94 Mb
613:external carotid artery
2199:10.1074/jbc.M305838200
2155:10.1038/sj.bjc.6601301
2091:10.1074/jbc.M301157200
2056:10.1074/jbc.M204591200
2022:10.1006/geno.2002.6770
1978:10.1073/pnas.251401598
1928:10.1038/sj.onc.1203647
1654:10.1073/pnas.92.8.3264
1601:10.1006/geno.2002.6770
1467:10.1074/jbc.M804753200
860:protein ubiquitination
609:ventral tegmental area
794:extracellular exosome
416:Chromosome 18 (mouse)
733:transferase activity
563:gastrocnemius muscle
314:Chromosome 5 (human)
69:List of PDB id codes
42:Available structures
2524:Heat shock proteins
1969:2001PNAS...9814422F
1698:1994PNAS...91.8797S
1645:1995PNAS...92.3264R
547:ganglionic eminence
3339:This article on a
1005:ENSMUSG00000091896
808:Biological process
772:Cellular component
738:nucleotide binding
726:Molecular function
559:right uterine tube
264:UBE2D2 - orthologs
3360:
3359:
3321:
3320:
3317:
3316:
2826:Protein targeting
2820:
2819:
2468:
2467:
1224:
1223:
1220:
1219:
1193:
1192:
1158:
1157:
1137:
1136:
1107:
1106:
1086:
1085:
1056:
1055:
1037:
1036:
1011:
1010:
992:
991:
966:
965:
947:
946:
895:
894:
710:
709:
706:
705:
661:
660:
648:
647:
586:
585:
484:
483:
383:
382:
196:
195:
192:
191:
52:Ortholog search:
3410:
3381:
3374:
3367:
3335:
3328:
3173:
3086:Ubiquitin ligase
2852:(ubiquitylation)
2790:Alpha crystallin
2520:
2495:
2488:
2481:
2472:
2454:
2439:
2424:
2409:
2394:
2379:
2364:
2349:
2334:
2319:
2299:
2292:
2285:
2276:
2270:
2241:
2211:
2201:
2176:
2166:
2133:
2103:
2093:
2068:
2058:
2033:
2000:
1990:
1980:
1947:
1909:
1899:
1866:
1849:(5438): 309β12.
1837:
1827:
1818:(21): 14823β30.
1802:
1764:
1754:
1745:(24): 15085β92.
1729:
1719:
1709:
1692:(19): 8797β801.
1676:
1666:
1656:
1613:
1612:
1580:
1571:
1570:
1560:
1551:(24): 15085β92.
1536:
1527:
1526:
1489:
1480:
1479:
1469:
1460:(46): 31633β40.
1445:
1439:
1438:
1431:
1422:
1421:
1411:
1402:(51): 30408β14.
1387:
1381:
1380:
1369:
1363:
1362:
1351:
1345:
1335:
1324:
1314:
1206:
1205:
1177:
1170:
1153:
1141:
1132:
1116:
1112:RefSeq (protein)
1102:
1090:
1081:
1065:
1041:
1022:
996:
977:
951:
932:
901:
716:
702:
693:
686:
679:
672:
657:
597:
595:Top expressed in
590:
543:ventricular zone
535:
533:Top expressed in
528:
507:
490:
480:
467:
456:
441:
434:
428:
417:
405:
389:
379:
366:
355:
340:
333:
327:
316:
302:
286:
280:
266:
217:
210:
187:
66:
60:
39:
38:
33:
21:
3418:
3417:
3413:
3412:
3411:
3409:
3408:
3407:
3388:
3387:
3386:
3385:
3324:
3322:
3313:
3240:
3215:E3 SUMO ligase
3179:
3168:
3160:
2851:
2843:
2816:
2778:
2757:
2749:
2527:
2515:protein folding
2513:
2504:
2499:
2469:
2464:
2461:
2455:
2446:
2440:
2431:
2425:
2416:
2410:
2401:
2395:
2386:
2380:
2371:
2365:
2356:
2350:
2341:
2335:
2326:
2320:
2306:
2303:
2273:
2244:
2214:
2179:
2136:
2106:
2084:(24): 21930β7.
2071:
2036:
2003:
1963:(25): 14422β7.
1950:
1922:(31): 3529β36.
1912:
1869:
1840:
1805:
1767:
1732:
1679:
1626:
1622:
1620:Further reading
1617:
1616:
1582:
1581:
1574:
1538:
1537:
1530:
1491:
1490:
1483:
1447:
1446:
1442:
1433:
1432:
1425:
1389:
1388:
1384:
1371:
1370:
1366:
1353:
1352:
1348:
1336:
1327:
1315:
1306:
1301:
1296:
1255:
1246:
1215:View/Edit Mouse
1210:View/Edit Human
1173:
1166:
1163:Location (UCSC)
1149:
1128:
1124:
1098:
1077:
1073:
986:ENSG00000131508
879:
803:
767:
748:protein binding
698:
688:
687:
681:
680:
653:
644:
639:
637:median eminence
635:
631:
627:
625:mammillary body
623:
619:
615:
611:
607:
593:
582:
579:tibial arteries
577:
573:
569:
565:
561:
557:
553:
549:
545:
531:
475:
462:
454:
444:
443:
442:
435:
415:
392:Gene location (
374:
361:
353:
343:
342:
341:
334:
312:
289:Gene location (
276:
226:
213:
206:
75:
53:
19:
12:
11:
5:
3416:
3414:
3406:
3405:
3400:
3390:
3389:
3384:
3383:
3376:
3369:
3361:
3358:
3357:
3336:
3319:
3318:
3315:
3314:
3312:
3311:
3305:
3304:
3299:
3294:
3289:
3284:
3279:
3274:
3264:
3259:
3254:
3248:
3246:
3242:
3241:
3239:
3238:
3237:
3236:
3231:
3226:
3221:
3212:
3211:
3210:
3209:
3200:
3199:
3198:
3197:
3192:
3183:
3181:
3170:
3162:
3161:
3159:
3158:
3153:
3148:
3142:
3141:
3136:
3131:
3121:
3120:
3119:
3118:
3113:
3108:
3103:
3098:
3093:
3081:
3080:
3079:
3078:
3073:
3068:
3063:
3058:
3053:
3047:
3042:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2977:
2972:
2967:
2962:
2957:
2952:
2947:
2942:
2937:
2932:
2927:
2922:
2910:
2909:
2908:
2907:
2902:
2897:
2892:
2887:
2882:
2877:
2872:
2867:
2855:
2853:
2845:
2844:
2842:
2841:
2836:
2834:Signal peptide
2830:
2828:
2822:
2821:
2818:
2817:
2815:
2814:
2813:
2812:
2807:
2797:
2792:
2786:
2784:
2780:
2779:
2777:
2776:
2775:
2774:
2769:
2764:
2759:
2755:
2751:
2747:
2737:
2736:
2735:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2663:
2662:
2661:
2660:
2655:
2650:
2645:
2640:
2635:
2630:
2625:
2620:
2615:
2610:
2605:
2600:
2595:
2590:
2585:
2580:
2575:
2570:
2559:
2558:
2549:
2544:
2539:
2533:
2531:
2517:
2506:
2505:
2500:
2498:
2497:
2490:
2483:
2475:
2466:
2465:
2463:
2462:
2456:
2449:
2447:
2441:
2434:
2432:
2426:
2419:
2417:
2411:
2404:
2402:
2396:
2389:
2387:
2381:
2374:
2372:
2366:
2359:
2357:
2351:
2344:
2342:
2336:
2329:
2327:
2321:
2314:
2311:
2308:
2307:
2304:
2302:
2301:
2294:
2287:
2279:
2272:
2271:
2242:
2212:
2192:(6): 4869β76.
2177:
2149:(8): 1538β44.
2134:
2104:
2069:
2049:(7): 5255β63.
2034:
2001:
1948:
1910:
1882:(13): 4691β8.
1867:
1838:
1803:
1777:(11): 751β63.
1771:Genes to Cells
1765:
1730:
1677:
1623:
1621:
1618:
1615:
1614:
1572:
1528:
1501:(11): 751β63.
1495:Genes to Cells
1481:
1440:
1423:
1382:
1364:
1346:
1325:
1303:
1302:
1300:
1297:
1295:
1294:
1288:
1282:
1276:
1270:
1263:
1254:
1251:
1245:
1242:
1222:
1221:
1218:
1217:
1212:
1202:
1201:
1195:
1194:
1191:
1190:
1188:
1186:
1179:
1178:
1171:
1164:
1160:
1159:
1156:
1155:
1145:
1144:
1138:
1135:
1134:
1120:
1119:
1113:
1109:
1108:
1105:
1104:
1094:
1093:
1087:
1084:
1083:
1069:
1068:
1062:
1058:
1057:
1054:
1053:
1045:
1044:
1038:
1035:
1034:
1026:
1025:
1019:
1013:
1012:
1009:
1008:
1000:
999:
993:
990:
989:
981:
980:
974:
968:
967:
964:
963:
955:
954:
948:
945:
944:
936:
935:
929:
923:
922:
917:
912:
908:
907:
897:
896:
893:
892:
881:
880:
878:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
811:
809:
805:
804:
802:
801:
796:
791:
786:
781:
775:
773:
769:
768:
766:
765:
760:
755:
750:
745:
740:
735:
729:
727:
723:
722:
712:
711:
708:
707:
704:
703:
695:
694:
669:
663:
662:
659:
658:
650:
649:
646:
645:
643:
642:
638:
634:
630:
626:
622:
618:
614:
610:
606:
602:
599:
598:
587:
584:
583:
581:
580:
576:
572:
568:
564:
560:
556:
552:
548:
544:
540:
537:
536:
524:
523:
515:
504:
498:
497:
494:RNA expression
486:
485:
482:
481:
473:
469:
468:
460:
457:
452:
446:
445:
436:
429:
423:
419:
418:
413:
407:
406:
398:
397:
385:
384:
381:
380:
372:
368:
367:
359:
356:
351:
345:
344:
335:
328:
322:
318:
317:
310:
304:
303:
295:
294:
282:
281:
274:
268:
267:
224:
220:
219:
211:
203:
202:
198:
197:
194:
193:
190:
189:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3415:
3404:
3401:
3399:
3396:
3395:
3393:
3382:
3377:
3375:
3370:
3368:
3363:
3362:
3356:
3354:
3350:
3346:
3342:
3337:
3334:
3330:
3325:
3310:
3307:
3306:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3272:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3250:
3249:
3247:
3243:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3216:
3214:
3213:
3208:
3205:
3204:
3202:
3201:
3196:
3193:
3191:
3188:
3187:
3185:
3184:
3182:
3180:(SUMOylation)
3178:
3174:
3171:
3167:
3163:
3157:
3154:
3152:
3149:
3147:
3144:
3143:
3140:
3137:
3135:
3132:
3130:
3126:
3123:
3122:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3088:
3087:
3083:
3082:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2917:
2916:
2912:
2911:
2906:
2903:
2901:
2898:
2896:
2893:
2891:
2888:
2886:
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2863:
2862:
2861:
2857:
2856:
2854:
2850:
2846:
2840:
2837:
2835:
2832:
2831:
2829:
2827:
2823:
2811:
2808:
2806:
2803:
2802:
2801:
2798:
2796:
2793:
2791:
2788:
2787:
2785:
2781:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2752:
2750:
2744:
2743:
2742:
2739:
2738:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2669:
2668:
2665:
2664:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2571:
2569:
2566:
2565:
2564:
2561:
2560:
2557:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2534:
2532:
2530:
2525:
2521:
2518:
2516:
2511:
2507:
2503:
2496:
2491:
2489:
2484:
2482:
2477:
2476:
2473:
2459:
2453:
2448:
2444:
2438:
2433:
2429:
2423:
2418:
2414:
2408:
2403:
2399:
2393:
2388:
2384:
2378:
2373:
2369:
2363:
2358:
2354:
2348:
2343:
2339:
2333:
2328:
2324:
2318:
2313:
2309:
2300:
2295:
2293:
2288:
2286:
2281:
2280:
2277:
2268:
2264:
2260:
2256:
2253:(1): 157β65.
2252:
2248:
2243:
2239:
2235:
2231:
2227:
2224:(1): 153β67.
2223:
2219:
2213:
2209:
2205:
2200:
2195:
2191:
2187:
2183:
2178:
2174:
2170:
2165:
2160:
2156:
2152:
2148:
2144:
2140:
2135:
2131:
2127:
2123:
2119:
2115:
2111:
2105:
2101:
2097:
2092:
2087:
2083:
2079:
2075:
2070:
2066:
2062:
2057:
2052:
2048:
2044:
2040:
2035:
2031:
2027:
2023:
2019:
2016:(6): 869β74.
2015:
2011:
2007:
2002:
1998:
1994:
1989:
1984:
1979:
1974:
1970:
1966:
1962:
1958:
1954:
1949:
1945:
1941:
1937:
1933:
1929:
1925:
1921:
1917:
1911:
1907:
1903:
1898:
1893:
1889:
1885:
1881:
1877:
1873:
1868:
1864:
1860:
1856:
1852:
1848:
1844:
1839:
1835:
1831:
1826:
1821:
1817:
1813:
1809:
1804:
1800:
1796:
1792:
1788:
1784:
1780:
1776:
1772:
1766:
1762:
1758:
1753:
1748:
1744:
1740:
1736:
1731:
1727:
1723:
1718:
1713:
1708:
1703:
1699:
1695:
1691:
1687:
1683:
1678:
1674:
1670:
1665:
1660:
1655:
1650:
1646:
1642:
1639:(8): 3264β8.
1638:
1634:
1630:
1625:
1624:
1619:
1610:
1606:
1602:
1598:
1595:(6): 869β74.
1594:
1590:
1586:
1579:
1577:
1573:
1568:
1564:
1559:
1554:
1550:
1546:
1542:
1535:
1533:
1529:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1488:
1486:
1482:
1477:
1473:
1468:
1463:
1459:
1455:
1451:
1444:
1441:
1436:
1430:
1428:
1424:
1419:
1415:
1410:
1405:
1401:
1397:
1393:
1386:
1383:
1378:
1374:
1368:
1365:
1360:
1356:
1350:
1347:
1343:
1339:
1334:
1332:
1330:
1326:
1322:
1318:
1313:
1311:
1309:
1305:
1298:
1292:
1289:
1286:
1283:
1280:
1277:
1274:
1271:
1268:
1265:
1264:
1262:
1260:
1252:
1250:
1243:
1241:
1239:
1236:
1232:
1228:
1216:
1211:
1207:
1203:
1200:
1196:
1189:
1187:
1184:
1180:
1176:
1172:
1169:
1165:
1161:
1154:
1152:
1146:
1142:
1139:
1133:
1131:
1127:
1121:
1117:
1114:
1110:
1103:
1101:
1095:
1091:
1088:
1082:
1080:
1076:
1070:
1066:
1063:
1061:RefSeq (mRNA)
1059:
1052:
1051:
1046:
1042:
1039:
1033:
1032:
1027:
1023:
1020:
1018:
1014:
1007:
1006:
1001:
997:
994:
988:
987:
982:
978:
975:
973:
969:
962:
961:
956:
952:
949:
943:
942:
937:
933:
930:
928:
924:
921:
918:
916:
913:
909:
906:
902:
898:
891:
887:
882:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
812:
810:
807:
806:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
776:
774:
771:
770:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
730:
728:
725:
724:
721:
720:Gene ontology
717:
713:
701:
696:
692:
685:
678:
673:
670:
668:
664:
656:
651:
640:
636:
632:
628:
624:
620:
616:
612:
608:
605:Gonadal ridge
604:
603:
600:
596:
591:
588:
578:
574:
570:
566:
562:
558:
554:
550:
546:
542:
541:
538:
534:
529:
526:
525:
522:
520:
516:
514:
513:
509:
508:
505:
503:
499:
495:
491:
487:
479:
474:
470:
466:
461:
455:18|18 B2
451:
447:
440:
433:
427:
420:
412:
408:
404:
399:
395:
390:
386:
378:
373:
369:
365:
360:
350:
346:
339:
332:
326:
319:
315:
309:
305:
301:
296:
292:
287:
283:
279:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
221:
216:
209:
204:
199:
188:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
3353:expanding it
3345:chromosome 5
3338:
3323:
3177:SUMO protein
2939:
2457:
2442:
2427:
2412:
2397:
2382:
2367:
2352:
2337:
2322:
2250:
2246:
2221:
2217:
2189:
2185:
2146:
2142:
2116:(1): 84β93.
2113:
2109:
2081:
2077:
2046:
2042:
2013:
2009:
1960:
1956:
1919:
1915:
1879:
1875:
1846:
1842:
1815:
1811:
1774:
1770:
1742:
1738:
1689:
1685:
1636:
1632:
1592:
1588:
1548:
1544:
1498:
1494:
1457:
1453:
1443:
1399:
1395:
1385:
1376:
1367:
1358:
1349:
1256:
1253:Interactions
1247:
1234:
1226:
1225:
1148:
1123:
1097:
1072:
1048:
1029:
1003:
984:
958:
939:
919:
914:
621:pineal gland
551:right testis
517:
510:
375:139,628,434
362:139,526,431
223:External IDs
74:
15:
3271:neddylation
2537:Hsp10/GroES
2529:Chaperonins
2305:PDB gallery
789:nucleoplasm
753:ATP binding
633:human fetus
567:granulocyte
555:left testis
476:35,942,547
463:35,904,611
201:Identifiers
3392:Categories
2563:Hsp40/DnaJ
2510:Chaperones
1344:, May 2017
1323:, May 2017
1299:References
521:(ortholog)
244:HomoloGene
3343:on human
2849:Ubiquitin
2795:Clusterin
1151:NP_064296
1130:NP_862821
1126:NP_003330
1100:NM_019912
1079:NM_181838
1075:NM_003339
905:Orthologs
272:EC number
252:GeneCards
3129:Ataxin 3
2267:15001359
2238:14667819
2218:Genomics
2208:14612456
2173:14562029
2130:12878161
2100:12670957
2065:12431996
2030:12036302
2010:Genomics
1997:11724934
1944:24267499
1936:10918611
1916:Oncogene
1906:10848595
1863:10514377
1834:10329681
1609:12036302
1589:Genomics
1476:18784070
1340:–
1319:–
1259:interact
1244:Function
1199:Wikidata
884:Sources:
278:2.3.2.24
3052:(CDC34)
2164:2394340
1965:Bibcode
1843:Science
1799:1653536
1791:9990509
1761:9182527
1726:8090726
1694:Bibcode
1673:7724550
1641:Bibcode
1567:9182527
1523:1653536
1515:9990509
1418:8530467
1342:Ensembl
1321:Ensembl
1231:protein
1017:UniProt
972:Ensembl
911:Species
890:QuickGO
779:cytosol
496:pattern
240:1930715
208:Aliases
3096:Cullin
2265:
2236:
2206:
2171:
2161:
2128:
2098:
2063:
2028:
1995:
1985:
1942:
1934:
1904:
1894:
1861:
1832:
1797:
1789:
1759:
1724:
1714:
1671:
1661:
1607:
1565:
1521:
1513:
1474:
1416:
1287:, and
1261:with:
1235:UBE2D2
1185:search
1183:PubMed
1050:P62838
1031:P62837
927:Entrez
667:BioGPS
575:rectum
354:5q31.2
256:UBE2D2
232:602962
215:UBE2D2
24:UBE2D2
3347:is a
3287:ATG12
3277:FAT10
3267:NEDD8
3252:ISG15
3245:Other
3234:PIAS4
3229:PIAS3
3224:PIAS2
3219:PIAS1
3169:(UBL)
3151:BIRC6
3111:FANCL
2783:Other
2772:TRAP1
2741:Hsp90
2667:Hsp70
2556:GroEL
2552:HSP60
2547:Hsp47
2542:Hsp27
1988:64697
1940:S2CID
1897:85887
1795:S2CID
1717:44693
1664:42146
1519:S2CID
1291:UBE3A
1273:NEDD4
1229:is a
960:56550
920:Mouse
915:Human
886:Amigo
571:sperm
519:Mouse
512:Human
459:Start
394:Mouse
358:Start
291:Human
3349:stub
3341:gene
3302:UBL5
3292:FUB1
3282:ATG8
3262:UFM1
3257:URM1
3207:UBC9
3195:SAE2
3190:SAE1
3156:UFC1
3146:ATG3
3139:CYLD
3134:USP6
3116:UBR1
3106:MDM2
2905:SAE1
2900:NAE1
2895:ATG7
2890:UBA7
2885:UBA6
2880:UBA5
2875:UBA3
2870:UBA2
2865:UBA1
2810:SMN2
2805:SMN1
2458:2fuh
2443:2esq
2428:2esp
2413:2eso
2398:2esk
2383:2c4o
2368:1z2u
2353:1x23
2338:1w4u
2323:1ur6
2263:PMID
2234:PMID
2204:PMID
2169:PMID
2126:PMID
2096:PMID
2061:PMID
2026:PMID
1993:PMID
1932:PMID
1902:PMID
1859:PMID
1830:PMID
1787:PMID
1757:PMID
1722:PMID
1669:PMID
1605:PMID
1563:PMID
1511:PMID
1472:PMID
1414:PMID
1285:PJA2
1279:PJA1
1238:gene
941:7322
502:Bgee
450:Band
411:Chr.
349:Band
308:Chr.
248:2506
228:OMIM
185:5EDV
181:5D1M
177:5D0K
173:5D0M
169:5D1K
165:5D1L
161:4WZ3
157:4V3L
153:4V3K
149:4LDT
145:4DDG
141:4AUQ
137:4A4C
133:4A4B
129:4A49
125:3ZNI
121:3TGD
117:3L1Y
113:3JW0
109:3JVZ
105:3A33
101:2ESQ
97:2ESP
93:2ESO
89:2ESK
85:2CLW
81:1W4U
77:1UR6
58:RCSB
55:PDBe
3297:MUB
3101:CBL
3091:VHL
3084:E3
2913:E2
2858:E1
2727:12A
2658:C19
2653:C14
2648:C13
2643:C11
2638:C10
2593:B11
2255:doi
2251:337
2226:doi
2194:doi
2190:279
2159:PMC
2151:doi
2118:doi
2114:288
2086:doi
2082:278
2051:doi
2047:278
2018:doi
1983:PMC
1973:doi
1924:doi
1892:PMC
1884:doi
1851:doi
1847:286
1820:doi
1816:274
1779:doi
1747:doi
1743:272
1712:PMC
1702:doi
1659:PMC
1649:doi
1597:doi
1553:doi
1549:272
1503:doi
1462:doi
1458:283
1404:doi
1400:270
472:End
371:End
260:OMA
236:MGI
48:PDB
3394::
3127::
3071:V2
3066:V1
3056:R2
3050:R1
3045:Q2
3040:Q1
3020:L6
3015:L4
3010:L3
3005:L2
3000:L1
2990:J2
2985:J1
2970:G2
2965:G1
2960:E3
2955:E2
2950:E1
2945:D3
2940:D2
2935:D1
2767:ER
2732:14
2697:4L
2682:1L
2677:1B
2672:1A
2633:C7
2628:C6
2623:C5
2618:C3
2613:C1
2608:B9
2603:B6
2598:B4
2588:B2
2583:B1
2578:A3
2573:A2
2568:A1
2261:.
2249:.
2232:.
2222:83
2220:.
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2188:.
2184:.
2167:.
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2076:.
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2041:.
2024:.
2014:79
2012:.
2008:.
1991:.
1981:.
1971:.
1961:98
1959:.
1955:.
1938:.
1930:.
1920:19
1918:.
1900:.
1890:.
1880:20
1878:.
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3076:Z
3061:S
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3030:N
3025:M
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2920:A
2762:Ξ²
2756:2
2754:Ξ±
2748:1
2746:Ξ±
2722:9
2717:8
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