326:
303:
200:
225:
3107:
591:
584:
577:
3092:
29:
332:
231:
1326:
via the ubiquitination of the NK-ΞΊB precursor. This association was observed in
European, Asian, and African-American populations. UBE2L3 has been linked to natural killer cell cytotoxic function, and high UBE2L3 levels had contributed to clearing chronic HBV infection. UBE2L3 controls the protein
55:
1933:
Zuo XB, Sheng YJ, Hu SJ, Gao JP, Li Y, Tang HY, Tang XF, Cheng H, Yin XY, Wen LL, Sun LD, Yang S, Cui Y, Zhang XJ (2014). "Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in
Chinese population".
1274:. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). E2s play a key role in the whole ubiquitin (Ub) transfer pathway and are responsible for Ub
2524:
Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (November 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes".
2022:
Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J (June 2010).
2787:
Robinson PA, Leek JP, Thompson J, Carr IM, Bailey A, Moynihan TP, Coletta PL, Lench NJ, Markham AF (1995). "A human ubiquitin conjugating enzyme, L-UBC, maps in the
Alzheimer's disease locus on chromosome 14q24.3".
1339:
to repair DNA double-strand break. Repair by NHEJ leads to radial chromosomes and cell death. UBE2L3 depletion may become a novel strategy in enhancing the effect of anticancer therapies. The haplotype of
1980:
Fransen K, Visschedijk MC, van
Sommeren S, Fu JY, Franke L, Festen EA, Stokkers PC, van Bodegraven AA, Crusius JB, Hommes DW, Zanen P, de Jong DJ, Wijmenga C, van Diemen CC, Weersma RK (September 2010).
1585:
Moynihan TP, Cole CG, Dunham I, O'Neil L, Markham AF, Robinson PA (September 1998). "Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3".
2644:
Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP (November 1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade".
1728:
Eletr ZM, Huang DT, Duda DM, Schulman BA, Kuhlman B (October 2005). "E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer".
2121:
Mitchell LJ, Moody CJ (November 2014). "Solar photochemical oxidation of alcohols using catalytic hydroquinone and copper nanoparticles under oxygen: oxidative cleavage of lignin models".
2568:
Bruce MC, Kanelis V, Fouladkou F, Debonneville A, Staub O, Rotin D (October 2008). "Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain".
3147:
3400:
2903:
Ardley HC, Moynihan TP, Markham AF, Robinson PA (2000). "Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7".
3106:
339:
238:
1542:
Moynihan TP, Ardley HC, Leek JP, Thompson J, Brindle NS, Markham AF, Robinson PA (October 1996). "Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3".
1278:. Unlike many E2s that transfer Ub with RINGs, UBE2L3 has E3-independent reactivity with lysine. This enzyme is demonstrated to participate in the ubiquitination of
1185:
to target proteins for degradation. The role of UBE2L3 in the ubiquitination of the NF-ΞΊB precursor implicated it in various major autoimmune diseases, including
1294:. Specifically, UBE2L3 manages cell cycle regulatory protein levels via the ubiquitin proteolytic pathway (UPP) during the G1/S transition and during the actual
2754:"Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates"
3140:
884:
161:
2985:
Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity".
865:
3133:
1642:
Hu Z, Liu Y, Zhai X, Dai J, Jin G, Wang L, et al. (Dec 2013). "New loci associated with chronic hepatitis B virus infection in Han
Chinese".
3745:
2934:"Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1"
3091:
3988:
3071:
1524:
52:
1506:
2291:"Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7"
325:
3963:
2605:"Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5"
1108:
1115:
302:
2474:"Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling"
2392:"Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7"
1625:
3156:
1983:"Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease"
1493:
1472:
1307:
2250:"The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1"
3356:
224:
199:
1489:
2862:"A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4"
2072:
Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T (August 2009).
1468:
3569:
1323:
1198:
141:
3514:
1357:
338:
237:
2209:"Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP"
1345:
331:
230:
3064:
2074:"A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency"
2681:"Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes"
3454:
929:
149:
3779:
2025:"53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers"
910:
3951:
3014:
Obin M, Lee BY, Meinke G, Bohm A, Lee RH, Gaudet R, Hopp JA, Arshavsky VY, Willardson BM, Taylor A (2002).
3820:
1226:. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
2248:
Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (October 1999).
3201:
2390:
Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A, Baron R (October 1999).
213:
3057:
2945:
2158:"The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population"
1311:
1186:
128:
3164:
1332:
1062:
1058:
1003:
999:
2827:"Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity"
1070:
3810:
3178:
2891:
2813:
2550:
1959:
1753:
1710:
1667:
1567:
1275:
173:
1194:
1091:
1066:
1032:
1011:
1007:
590:
583:
576:
3480:
3037:
3002:
2973:
2920:
2883:
2848:
2805:
2775:
2723:
2702:
2661:
2626:
2585:
2542:
2503:
2454:
2413:
2372:
2312:
2271:
2230:
2189:
2138:
2103:
2054:
2004:
1951:
1908:
1854:
1802:
1745:
1702:
1659:
1602:
1559:
121:
45:
1698:
3740:
3699:
3694:
3669:
3659:
3654:
3644:
3444:
3027:
2994:
2963:
2953:
2912:
2873:
2838:
2797:
2765:
2692:
2653:
2616:
2577:
2534:
2493:
2485:
2444:
2403:
2362:
2354:
2302:
2261:
2220:
2179:
2169:
2130:
2093:
2085:
2044:
2036:
1994:
1943:
1898:
1890:
1844:
1836:
1792:
1784:
1737:
1694:
1651:
1594:
1551:
1247:
418:
349:
293:
248:
169:
3715:
3649:
3946:
3169:
1395:
393:
2949:
2752:
Blumenfeld N, Gonen H, Mayer A, Smith CE, Siegel NR, Schwartz AL, Ciechanover A (1994).
28:
3493:
3488:
2433:"Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases"
2367:
2342:
2184:
2157:
2098:
2073:
2049:
2024:
1903:
1878:
1849:
1824:
1797:
1772:
1315:
1271:
1235:
1190:
1182:
2916:
2878:
2861:
2770:
2753:
2498:
2473:
2449:
2432:
2225:
2208:
1877:
Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, et al. (Jul 2012).
1270:
is an important cellular mechanism for targeting abnormal or short-lived proteins for
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
723:
718:
713:
708:
703:
698:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
3982:
3115:: STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
3016:"Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin"
2968:
2933:
2732:
2538:
1219:
619:
2895:
2156:
Wang Y, Zhu YF, Wang Q, Xu J, Yan N, Xu J, Shi LF, He ST, Zhang JA (19 April 2016).
1963:
1757:
1714:
1671:
1571:
3849:
3831:
2817:
2554:
411:
190:
153:
2657:
3125:
2089:
177:
3925:
3793:
2472:
Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (September 2002).
1879:"A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus"
1529:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1511:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2343:"Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7"
2207:
Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (November 2003).
1310:(GWAS), UBE2L3 has been associated with several autoimmune diseases, including
1234:
There are 38 E2 enzymes in humans. They all contain a conserved catalytic core
494:
3755:
3183:
2174:
1947:
1291:
1239:
310:
207:
157:
2843:
2826:
2408:
2391:
2266:
2249:
3503:
3449:
2358:
1267:
1255:
829:
554:
432:
377:
364:
276:
263:
165:
3041:
3032:
3015:
3006:
2998:
2977:
2958:
2924:
2887:
2706:
2697:
2680:
2665:
2621:
2604:
2589:
2507:
2489:
2458:
2417:
2376:
2316:
2307:
2290:
2275:
2234:
2193:
2142:
2107:
2058:
2008:
1955:
1912:
1858:
1825:"UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids"
1806:
1749:
1706:
1663:
1598:
2852:
2809:
2779:
2630:
2546:
1606:
1563:
1555:
1155:
1150:
3783:
3416:
3408:
1999:
1982:
1377:
1335:
repair choice. Loss of UBE2L3 stabilizes 53BP1 and force cells to choose
1287:
1139:
974:
955:
2603:
Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (February 1996).
1894:
1840:
1238:
that interacts with E1 and E3 and many E2s possess additional N- and/or
3534:
3421:
3381:
3312:
3307:
3302:
3297:
3292:
3247:
2801:
2737:
2727:
2581:
1788:
1407:
1295:
1290:
precursor p105 in vitro. UBE2L3 is primarily known for its role in the
1251:
1171:
941:
896:
2134:
2040:
98:
94:
90:
86:
82:
78:
74:
3750:
3725:
3720:
3710:
3674:
3639:
3624:
3619:
3614:
3609:
3604:
3599:
3594:
3589:
3554:
3539:
3386:
3351:
3336:
3331:
3326:
3287:
3282:
3277:
3272:
3267:
3262:
3257:
3252:
3242:
3237:
3232:
3227:
3222:
1685:
Deshaies RJ, Joazeiro CA (2009). "RING domain E3 ubiquitin ligases".
1413:
1401:
1243:
1123:
851:
1741:
1655:
1242:
protein sequences. In contrast to other E2s, residues necessary for
3941:
3931:
3921:
3906:
3888:
3883:
3878:
3873:
3805:
3765:
3730:
3704:
3689:
3684:
3679:
3634:
3629:
3584:
3579:
3574:
3544:
3529:
3426:
3395:
3376:
3371:
3366:
3361:
3346:
3341:
3321:
3217:
3210:
3206:
3196:
3191:
1443:
1437:
1431:
1425:
1419:
1389:
1383:
1371:
1365:
1328:
1283:
1223:
2289:
Ardley HC, Tan NG, Rose SA, Markham AF, Robinson PA (June 2001).
814:
810:
3956:
3936:
3916:
3911:
3861:
3844:
3800:
3788:
3770:
3760:
3559:
3549:
3524:
3519:
3464:
3459:
2932:
Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM (2000).
1336:
1178:
145:
132:, E2-F1, L-UBC, UBCH7, UbcM4, ubiquitin conjugating enzyme E2 L3
3129:
3053:
599:
3049:
1279:
785:
positive regulation of ubiquitin-protein transferase activity
2722:
Overview of all the structural information available in the
2679:
Pringa E, Martinez-Noel G, Muller U, Harbers K (June 2001).
2860:
Martinez-Noel G, Niedenthal R, Tamura T, Harbers K (1999).
1823:
Wenzel DM, Lissounov A, Brzovic PS, Klevit RE (June 2011).
1319:
3100:: STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY
2431:
Zheng N, Wang P, Jeffrey PD, Pavletich NP (August 2000).
760:
positive regulation of protein targeting to mitochondrion
1626:"Entrez Gene: UBE2L3 ubiquitin-conjugating enzyme E2L 3"
401:
1773:"E2s: structurally economical and functionally replete"
1246:
reactivity are absent: the D87 and D117 residues (in
566:
3899:
3830:
3819:
3502:
3479:
3437:
3177:
3163:
2341:Whitcomb EA, Dudek EJ, Liu Q, Taylor A (Jan 2009).
1084:
1051:
1025:
992:
1485:
1483:
1481:
1464:
1462:
1460:
348:
247:
658:ubiquitin-protein transferase activator activity
2336:
2334:
2332:
2330:
2328:
2326:
1975:
1973:
1928:
1926:
1924:
1922:
1872:
1870:
1868:
1818:
1816:
1771:Wenzel DM, Stoll KE, Klevit RE (January 2011).
2519:
2517:
1637:
1635:
1490:GRCm38: Ensembl release 89: ENSMUSG00000038965
3141:
3065:
795:positive regulation of protein ubiquitination
755:ubiquitin-dependent protein catabolic process
745:cellular response to steroid hormone stimulus
8:
2736:(Ubiquitin-conjugating enzyme E2 L3) at the
780:cellular response to glucocorticoid stimulus
1469:GRCh38: Ensembl release 89: ENSG00000185651
3827:
3174:
3148:
3134:
3126:
3072:
3058:
3050:
1181:. As an E2 enzyme, UBE2L3 participates in
825:
750:regulation of transcription, DNA-templated
615:
389:
288:
185:
63:
3031:
2967:
2957:
2877:
2842:
2769:
2696:
2620:
2497:
2448:
2407:
2366:
2306:
2265:
2224:
2183:
2173:
2097:
2048:
2029:Nature Structural & Molecular Biology
1998:
1902:
1848:
1796:
1730:Nature Structural & Molecular Biology
1699:10.1146/annurev.biochem.78.101807.093809
1620:
1618:
1616:
3087:
1456:
1348:in a Chinese Han population.(27094594)
1344:gene is also reported associated with
648:ubiquitin-protein transferase activity
18:
683:ubiquitin conjugating enzyme activity
353:
314:
309:
252:
211:
206:
7:
2825:Kumar S, Kao WH, Howley PM (1997).
3964:Prokaryotic ubiquitin-like protein
1266:The modification of proteins with
1170:(UBE2L3), also called UBCH7, is a
1168:Ubiquitin-conjugating enzyme E2 L3
1081:
1048:
1022:
989:
965:
946:
920:
901:
875:
856:
643:transcription coactivator activity
571:
489:
427:
406:
14:
1174:that in humans is encoded by the
775:protein K11-linked ubiquitination
3105:
3090:
2539:10.1046/j.1365-2443.1998.00227.x
2123:The Journal of Organic Chemistry
673:ubiquitin protein ligase binding
589:
582:
575:
337:
330:
324:
301:
236:
229:
223:
198:
27:
1308:genome-wide association studies
3494:Mitochondrial targeting signal
3157:Posttranslational modification
600:More reference expression data
555:More reference expression data
1:
2987:Biochem. Biophys. Res. Commun
2917:10.1016/s0167-4781(00)00024-5
2879:10.1016/S0014-5793(99)00823-6
2771:10.1016/S0021-9258(17)36920-X
2658:10.1126/science.286.5443.1321
2450:10.1016/S0092-8674(00)00057-X
2347:Molecular Biology of the Cell
2226:10.1016/s0014-5793(03)01235-3
1687:Annual Review of Biochemistry
790:cell population proliferation
322:
221:
16:Protein-coding gene in humans
3989:Genes on human chromosome 22
3570:Ubiquitin-conjugating enzyme
2938:Proc. Natl. Acad. Sci. U.S.A
2090:10.1016/j.molcel.2009.06.037
1199:systemic lupus erythematosus
770:transcription, DNA-templated
3858:E2 SUMO-conjugating enzyme
3515:Ubiquitin-activating enzyme
1250:numbering) are replaced by
740:cell cycle phase transition
4005:
3841:E1 SUMO-activating enzyme
765:protein polyubiquitination
451:mucosa of transverse colon
3085:
2175:10.1186/s12902-016-0098-6
1948:10.1007/s00296-013-2864-3
1525:"Mouse PubMed Reference:"
1507:"Human PubMed Reference:"
1356:UBE2L3 has been shown to
1154:
1149:
1145:
1138:
1122:
1103:
1088:
1055:
1044:
1029:
996:
985:
972:
968:
953:
949:
940:
927:
923:
908:
904:
895:
882:
878:
863:
859:
850:
835:
828:
824:
808:
618:
614:
597:
574:
565:
552:
501:
492:
479:anterior cingulate cortex
439:
430:
400:
392:
388:
371:
358:
321:
300:
291:
287:
270:
257:
220:
197:
188:
184:
139:
136:
126:
119:
114:
71:
66:
49:
44:
39:
35:
26:
21:
3455:Survival of motor neuron
2844:10.1074/jbc.272.21.13548
2409:10.1074/jbc.274.44.31707
2267:10.1074/jbc.274.43.30963
1987:Human Molecular Genetics
1116:Chr 16: 16.97 β 17.02 Mb
1109:Chr 22: 21.55 β 21.62 Mb
704:ubiquitin ligase complex
3821:Ubiquitin-like proteins
3780:Deubiquitinating enzyme
2359:10.1091/mbc.E08-01-0036
2162:BMC Endocrine Disorders
1777:The Biochemical Journal
1346:Hashimoto's thyroiditis
1331:and determines the DNA
1222:11.21, consisting of 6
517:internal carotid artery
3033:10.1074/jbc.M205308200
2999:10.1006/bbrc.2001.4414
2959:10.1073/pnas.240347797
2905:Biochim. Biophys. Acta
2698:10.1074/jbc.M100192200
2622:10.1074/jbc.271.5.2795
2308:10.1074/jbc.M011028200
1599:10.1006/geno.1998.5257
800:protein ubiquitination
355:16 A3|16 10.63 cM
1556:10.1007/s003359900155
1302:Clinical significance
709:extracellular exosome
316:Chromosome 16 (mouse)
214:Chromosome 22 (human)
2490:10.1093/emboj/cdf493
1187:rheumatoid arthritis
633:transferase activity
471:smooth muscle tissue
67:List of PDB id codes
40:Available structures
3179:Heat shock proteins
2950:2000PNAS...9713354Z
1895:10.1038/gene.2012.6
1841:10.1038/nature09966
1333:double-strand break
1218:gene is located at
463:islet of Langerhans
2802:10.1007/BF00354295
2582:10.1042/BJ20071708
2000:10.1093/hmg/ddq264
1883:Genes and Immunity
1789:10.1042/BJ20100985
1276:cellular signaling
930:ENSMUSG00000038965
733:Biological process
692:Cellular component
638:nucleotide binding
626:Molecular function
459:right frontal lobe
178:UBE2L3 - orthologs
3976:
3975:
3972:
3971:
3481:Protein targeting
3475:
3474:
3123:
3122:
2135:10.1021/jo5020917
2129:(22): 11091β100.
2041:10.1038/nsmb.1831
1165:
1164:
1161:
1160:
1134:
1133:
1099:
1098:
1078:
1077:
1040:
1039:
1019:
1018:
981:
980:
962:
961:
936:
935:
917:
916:
891:
890:
872:
871:
820:
819:
610:
609:
606:
605:
561:
560:
548:
547:
486:
485:
384:
383:
283:
282:
110:
109:
106:
105:
50:Ortholog search:
3996:
3828:
3741:Ubiquitin ligase
3507:(ubiquitylation)
3445:Alpha crystallin
3175:
3150:
3143:
3136:
3127:
3109:
3094:
3074:
3067:
3060:
3051:
3045:
3035:
3026:(46): 44566β75.
3010:
2981:
2971:
2961:
2928:
2899:
2881:
2856:
2846:
2837:(21): 13548β54.
2821:
2783:
2773:
2711:
2710:
2700:
2691:(22): 19617β23.
2676:
2670:
2669:
2652:(5443): 1321β6.
2641:
2635:
2634:
2624:
2600:
2594:
2593:
2565:
2559:
2558:
2521:
2512:
2511:
2501:
2484:(18): 4796β808.
2469:
2463:
2462:
2452:
2428:
2422:
2421:
2411:
2402:(44): 31707β12.
2387:
2381:
2380:
2370:
2338:
2321:
2320:
2310:
2286:
2280:
2279:
2269:
2245:
2239:
2238:
2228:
2204:
2198:
2197:
2187:
2177:
2153:
2147:
2146:
2118:
2112:
2111:
2101:
2069:
2063:
2062:
2052:
2019:
2013:
2012:
2002:
1977:
1968:
1967:
1930:
1917:
1916:
1906:
1874:
1863:
1862:
1852:
1820:
1811:
1810:
1800:
1768:
1762:
1761:
1725:
1719:
1718:
1682:
1676:
1675:
1650:(12): 1499β503.
1639:
1630:
1629:
1622:
1611:
1610:
1582:
1576:
1575:
1539:
1533:
1532:
1521:
1515:
1514:
1503:
1497:
1487:
1476:
1466:
1147:
1146:
1118:
1111:
1094:
1082:
1073:
1049:
1045:RefSeq (protein)
1035:
1023:
1014:
990:
966:
947:
921:
902:
876:
857:
826:
616:
602:
593:
586:
579:
572:
557:
525:ventricular zone
521:genital tubercle
497:
495:Top expressed in
490:
447:secondary oocyte
435:
433:Top expressed in
428:
407:
390:
380:
367:
356:
341:
334:
328:
317:
305:
289:
279:
266:
255:
240:
233:
227:
216:
202:
186:
180:
131:
124:
101:
64:
58:
37:
36:
31:
19:
4004:
4003:
3999:
3998:
3997:
3995:
3994:
3993:
3979:
3978:
3977:
3968:
3895:
3870:E3 SUMO ligase
3834:
3823:
3815:
3506:
3498:
3471:
3433:
3412:
3404:
3182:
3170:protein folding
3168:
3159:
3154:
3124:
3119:
3116:
3110:
3101:
3095:
3081:
3078:
3048:
3013:
2984:
2944:(24): 13354β9.
2931:
2902:
2859:
2824:
2786:
2764:(13): 9574β81.
2751:
2747:
2745:Further reading
2719:
2714:
2678:
2677:
2673:
2643:
2642:
2638:
2615:(5): 2795β800.
2602:
2601:
2597:
2567:
2566:
2562:
2523:
2522:
2515:
2471:
2470:
2466:
2430:
2429:
2425:
2389:
2388:
2384:
2340:
2339:
2324:
2301:(22): 19640β7.
2288:
2287:
2283:
2260:(43): 30963β8.
2247:
2246:
2242:
2206:
2205:
2201:
2155:
2154:
2150:
2120:
2119:
2115:
2071:
2070:
2066:
2021:
2020:
2016:
1979:
1978:
1971:
1932:
1931:
1920:
1876:
1875:
1866:
1835:(7349): 105β8.
1822:
1821:
1814:
1770:
1769:
1765:
1742:10.1038/nsmb984
1727:
1726:
1722:
1684:
1683:
1679:
1656:10.1038/ng.2809
1644:Nature Genetics
1641:
1640:
1633:
1624:
1623:
1614:
1584:
1583:
1579:
1541:
1540:
1536:
1523:
1522:
1518:
1505:
1504:
1500:
1488:
1479:
1467:
1458:
1454:
1449:
1354:
1304:
1264:
1232:
1212:
1207:
1195:Crohn's disease
1156:View/Edit Mouse
1151:View/Edit Human
1114:
1107:
1104:Location (UCSC)
1090:
1069:
1065:
1061:
1057:
1031:
1010:
1006:
1002:
998:
911:ENSG00000185651
804:
728:
687:
653:protein binding
598:
588:
587:
581:
580:
553:
544:
539:
535:
531:
527:
523:
519:
515:
511:
507:
493:
482:
477:
475:cingulate gyrus
473:
469:
467:Brodmann area 9
465:
461:
457:
453:
449:
445:
431:
375:
362:
354:
344:
343:
342:
335:
315:
292:Gene location (
274:
261:
253:
243:
242:
241:
234:
212:
189:Gene location (
140:
127:
120:
73:
51:
17:
12:
11:
5:
4002:
4000:
3992:
3991:
3981:
3980:
3974:
3973:
3970:
3969:
3967:
3966:
3960:
3959:
3954:
3949:
3944:
3939:
3934:
3929:
3919:
3914:
3909:
3903:
3901:
3897:
3896:
3894:
3893:
3892:
3891:
3886:
3881:
3876:
3867:
3866:
3865:
3864:
3855:
3854:
3853:
3852:
3847:
3838:
3836:
3825:
3817:
3816:
3814:
3813:
3808:
3803:
3797:
3796:
3791:
3786:
3776:
3775:
3774:
3773:
3768:
3763:
3758:
3753:
3748:
3736:
3735:
3734:
3733:
3728:
3723:
3718:
3713:
3708:
3702:
3697:
3692:
3687:
3682:
3677:
3672:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3577:
3565:
3564:
3563:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3527:
3522:
3510:
3508:
3500:
3499:
3497:
3496:
3491:
3489:Signal peptide
3485:
3483:
3477:
3476:
3473:
3472:
3470:
3469:
3468:
3467:
3462:
3452:
3447:
3441:
3439:
3435:
3434:
3432:
3431:
3430:
3429:
3424:
3419:
3414:
3410:
3406:
3402:
3392:
3391:
3390:
3389:
3384:
3379:
3374:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3334:
3329:
3318:
3317:
3316:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3214:
3213:
3204:
3199:
3194:
3188:
3186:
3172:
3161:
3160:
3155:
3153:
3152:
3145:
3138:
3130:
3121:
3120:
3118:
3117:
3111:
3104:
3102:
3096:
3089:
3086:
3083:
3082:
3079:
3077:
3076:
3069:
3062:
3054:
3047:
3046:
3011:
2982:
2929:
2911:(1β3): 57β64.
2900:
2857:
2822:
2796:(10): 725β31.
2784:
2748:
2746:
2743:
2742:
2741:
2718:
2717:External links
2715:
2713:
2712:
2671:
2636:
2595:
2560:
2533:(11): 751β63.
2513:
2464:
2423:
2382:
2322:
2281:
2240:
2199:
2148:
2113:
2078:Molecular Cell
2064:
2014:
1993:(17): 3482β8.
1969:
1918:
1864:
1812:
1763:
1720:
1677:
1631:
1612:
1577:
1534:
1516:
1498:
1477:
1455:
1453:
1450:
1448:
1447:
1441:
1435:
1429:
1423:
1417:
1411:
1405:
1399:
1393:
1387:
1381:
1375:
1369:
1362:
1353:
1350:
1316:celiac disease
1303:
1300:
1263:
1260:
1231:
1228:
1220:chromosome 22q
1211:
1208:
1206:
1203:
1191:celiac disease
1183:ubiquitination
1163:
1162:
1159:
1158:
1153:
1143:
1142:
1136:
1135:
1132:
1131:
1129:
1127:
1120:
1119:
1112:
1105:
1101:
1100:
1097:
1096:
1086:
1085:
1079:
1076:
1075:
1053:
1052:
1046:
1042:
1041:
1038:
1037:
1027:
1026:
1020:
1017:
1016:
994:
993:
987:
983:
982:
979:
978:
970:
969:
963:
960:
959:
951:
950:
944:
938:
937:
934:
933:
925:
924:
918:
915:
914:
906:
905:
899:
893:
892:
889:
888:
880:
879:
873:
870:
869:
861:
860:
854:
848:
847:
842:
837:
833:
832:
822:
821:
818:
817:
806:
805:
803:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
736:
734:
730:
729:
727:
726:
721:
716:
711:
706:
701:
695:
693:
689:
688:
686:
685:
680:
675:
670:
665:
663:enzyme binding
660:
655:
650:
645:
640:
635:
629:
627:
623:
622:
612:
611:
608:
607:
604:
603:
595:
594:
569:
563:
562:
559:
558:
550:
549:
546:
545:
543:
542:
538:
534:
530:
526:
522:
518:
514:
510:
509:tail of embryo
506:
502:
499:
498:
487:
484:
483:
481:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
437:
436:
424:
423:
415:
404:
398:
397:
394:RNA expression
386:
385:
382:
381:
373:
369:
368:
360:
357:
352:
346:
345:
336:
329:
323:
319:
318:
313:
307:
306:
298:
297:
285:
284:
281:
280:
272:
268:
267:
259:
256:
251:
245:
244:
235:
228:
222:
218:
217:
210:
204:
203:
195:
194:
182:
181:
138:
134:
133:
125:
117:
116:
112:
111:
108:
107:
104:
103:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4001:
3990:
3987:
3986:
3984:
3965:
3962:
3961:
3958:
3955:
3953:
3950:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3927:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3904:
3902:
3898:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3871:
3869:
3868:
3863:
3860:
3859:
3857:
3856:
3851:
3848:
3846:
3843:
3842:
3840:
3839:
3837:
3835:(SUMOylation)
3833:
3829:
3826:
3822:
3818:
3812:
3809:
3807:
3804:
3802:
3799:
3798:
3795:
3792:
3790:
3787:
3785:
3781:
3778:
3777:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3752:
3749:
3747:
3744:
3743:
3742:
3738:
3737:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3572:
3571:
3567:
3566:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3517:
3516:
3512:
3511:
3509:
3505:
3501:
3495:
3492:
3490:
3487:
3486:
3484:
3482:
3478:
3466:
3463:
3461:
3458:
3457:
3456:
3453:
3451:
3448:
3446:
3443:
3442:
3440:
3436:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3407:
3405:
3399:
3398:
3397:
3394:
3393:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3324:
3323:
3320:
3319:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3220:
3219:
3216:
3215:
3212:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3189:
3187:
3185:
3180:
3176:
3173:
3171:
3166:
3162:
3158:
3151:
3146:
3144:
3139:
3137:
3132:
3131:
3128:
3114:
3108:
3103:
3099:
3093:
3088:
3084:
3075:
3070:
3068:
3063:
3061:
3056:
3055:
3052:
3043:
3039:
3034:
3029:
3025:
3021:
3020:J. Biol. Chem
3017:
3012:
3008:
3004:
3000:
2996:
2993:(3): 706β13.
2992:
2988:
2983:
2979:
2975:
2970:
2965:
2960:
2955:
2951:
2947:
2943:
2939:
2935:
2930:
2926:
2922:
2918:
2914:
2910:
2906:
2901:
2897:
2893:
2889:
2885:
2880:
2875:
2872:(3): 257β61.
2871:
2867:
2863:
2858:
2854:
2850:
2845:
2840:
2836:
2832:
2831:J. Biol. Chem
2828:
2823:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2791:
2785:
2781:
2777:
2772:
2767:
2763:
2759:
2758:J. Biol. Chem
2755:
2750:
2749:
2744:
2739:
2735:
2734:
2729:
2725:
2721:
2720:
2716:
2708:
2704:
2699:
2694:
2690:
2686:
2685:J. Biol. Chem
2682:
2675:
2672:
2667:
2663:
2659:
2655:
2651:
2647:
2640:
2637:
2632:
2628:
2623:
2618:
2614:
2610:
2609:J. Biol. Chem
2606:
2599:
2596:
2591:
2587:
2583:
2579:
2576:(1): 155β63.
2575:
2571:
2564:
2561:
2556:
2552:
2548:
2544:
2540:
2536:
2532:
2528:
2520:
2518:
2514:
2509:
2505:
2500:
2495:
2491:
2487:
2483:
2479:
2475:
2468:
2465:
2460:
2456:
2451:
2446:
2442:
2438:
2434:
2427:
2424:
2419:
2415:
2410:
2405:
2401:
2397:
2396:J. Biol. Chem
2393:
2386:
2383:
2378:
2374:
2369:
2364:
2360:
2356:
2352:
2348:
2344:
2337:
2335:
2333:
2331:
2329:
2327:
2323:
2318:
2314:
2309:
2304:
2300:
2296:
2295:J. Biol. Chem
2292:
2285:
2282:
2277:
2273:
2268:
2263:
2259:
2255:
2254:J. Biol. Chem
2251:
2244:
2241:
2236:
2232:
2227:
2222:
2218:
2214:
2210:
2203:
2200:
2195:
2191:
2186:
2181:
2176:
2171:
2167:
2163:
2159:
2152:
2149:
2144:
2140:
2136:
2132:
2128:
2124:
2117:
2114:
2109:
2105:
2100:
2095:
2091:
2087:
2084:(4): 534β41.
2083:
2079:
2075:
2068:
2065:
2060:
2056:
2051:
2046:
2042:
2038:
2035:(6): 688β95.
2034:
2030:
2026:
2018:
2015:
2010:
2006:
2001:
1996:
1992:
1988:
1984:
1976:
1974:
1970:
1965:
1961:
1957:
1953:
1949:
1945:
1942:(4): 459β64.
1941:
1937:
1936:Rheumatol Int
1929:
1927:
1925:
1923:
1919:
1914:
1910:
1905:
1900:
1896:
1892:
1888:
1884:
1880:
1873:
1871:
1869:
1865:
1860:
1856:
1851:
1846:
1842:
1838:
1834:
1830:
1826:
1819:
1817:
1813:
1808:
1804:
1799:
1794:
1790:
1786:
1782:
1778:
1774:
1767:
1764:
1759:
1755:
1751:
1747:
1743:
1739:
1736:(10): 933β4.
1735:
1731:
1724:
1721:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1681:
1678:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1638:
1636:
1632:
1627:
1621:
1619:
1617:
1613:
1608:
1604:
1600:
1596:
1592:
1588:
1581:
1578:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1545:
1538:
1535:
1530:
1526:
1520:
1517:
1512:
1508:
1502:
1499:
1495:
1491:
1486:
1484:
1482:
1478:
1474:
1470:
1465:
1463:
1461:
1457:
1451:
1445:
1442:
1439:
1436:
1433:
1430:
1427:
1424:
1421:
1418:
1415:
1412:
1409:
1406:
1403:
1400:
1397:
1394:
1391:
1388:
1385:
1382:
1379:
1376:
1373:
1370:
1367:
1364:
1363:
1361:
1359:
1351:
1349:
1347:
1343:
1338:
1334:
1330:
1327:stability of
1325:
1321:
1317:
1313:
1309:
1301:
1299:
1297:
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1261:
1259:
1257:
1253:
1249:
1245:
1241:
1237:
1229:
1227:
1225:
1221:
1217:
1209:
1204:
1202:
1200:
1196:
1192:
1188:
1184:
1180:
1177:
1173:
1169:
1157:
1152:
1148:
1144:
1141:
1137:
1130:
1128:
1125:
1121:
1117:
1113:
1110:
1106:
1102:
1095:
1093:
1087:
1083:
1080:
1074:
1072:
1068:
1064:
1060:
1054:
1050:
1047:
1043:
1036:
1034:
1028:
1024:
1021:
1015:
1013:
1009:
1005:
1001:
995:
991:
988:
986:RefSeq (mRNA)
984:
977:
976:
971:
967:
964:
958:
957:
952:
948:
945:
943:
939:
932:
931:
926:
922:
919:
913:
912:
907:
903:
900:
898:
894:
887:
886:
881:
877:
874:
868:
867:
862:
858:
855:
853:
849:
846:
843:
841:
838:
834:
831:
827:
823:
816:
812:
807:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
737:
735:
732:
731:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
696:
694:
691:
690:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
621:
620:Gene ontology
617:
613:
601:
596:
592:
585:
578:
573:
570:
568:
564:
556:
551:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
503:
500:
496:
491:
488:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
441:
438:
434:
429:
426:
425:
422:
420:
416:
414:
413:
409:
408:
405:
403:
399:
395:
391:
387:
379:
374:
370:
366:
361:
351:
347:
340:
333:
327:
320:
312:
308:
304:
299:
295:
290:
286:
278:
273:
269:
265:
260:
250:
246:
239:
232:
226:
219:
215:
209:
205:
201:
196:
192:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
135:
130:
123:
118:
113:
102:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
3832:SUMO protein
3664:
3112:
3097:
3023:
3019:
2990:
2986:
2941:
2937:
2908:
2904:
2869:
2865:
2834:
2830:
2793:
2790:Mamm. Genome
2789:
2761:
2757:
2731:
2688:
2684:
2674:
2649:
2645:
2639:
2612:
2608:
2598:
2573:
2569:
2563:
2530:
2526:
2481:
2477:
2467:
2443:(4): 533β9.
2440:
2436:
2426:
2399:
2395:
2385:
2350:
2346:
2298:
2294:
2284:
2257:
2253:
2243:
2219:(3): 501β4.
2216:
2212:
2202:
2165:
2161:
2151:
2126:
2122:
2116:
2081:
2077:
2067:
2032:
2028:
2017:
1990:
1986:
1939:
1935:
1889:(5): 380β7.
1886:
1882:
1832:
1828:
1783:(1): 31β42.
1780:
1776:
1766:
1733:
1729:
1723:
1690:
1686:
1680:
1647:
1643:
1593:(1): 124β7.
1590:
1586:
1580:
1550:(7): 520β5.
1547:
1544:Mamm. Genome
1543:
1537:
1528:
1519:
1510:
1501:
1355:
1352:Interactions
1341:
1305:
1265:
1233:
1215:
1213:
1175:
1167:
1166:
1089:
1063:NP_001243285
1059:NP_001243284
1056:
1030:
1004:NM_001256356
1000:NM_001256355
997:
973:
954:
928:
909:
883:
864:
844:
839:
537:spermatocyte
417:
410:
137:External IDs
72:
3926:neddylation
3192:Hsp10/GroES
3184:Chaperonins
3080:PDB gallery
2527:Genes Cells
1693:: 399β434.
1272:degradation
1071:NP_003338.1
719:nucleoplasm
678:RNA binding
668:ATP binding
376:17,020,513
363:16,969,877
275:21,624,034
262:21,549,447
115:Identifiers
3218:Hsp40/DnaJ
3165:Chaperones
2570:Biochem. J
2353:(1): 1β9.
1496:, May 2017
1475:, May 2017
1452:References
1292:cell cycle
1286:, and the
1258:residues.
1240:C-terminal
1197:(CD), and
529:blastocyst
455:C1 segment
421:(ortholog)
158:HomoloGene
3504:Ubiquitin
3450:Clusterin
2866:FEBS Lett
2213:FEBS Lett
1268:ubiquitin
1205:Structure
1092:NP_033482
1067:NP_003338
1033:NM_009456
1012:NM_198157
1008:NM_003347
830:Orthologs
699:cytoplasm
505:spermatid
166:GeneCards
3983:Category
3784:Ataxin 3
3042:12215439
3007:11237715
2978:11078524
2925:10760570
2896:46159115
2888:10431818
2707:11274149
2666:10558980
2590:18498246
2508:12234920
2459:10966114
2418:10531381
2377:18946090
2317:11278816
2276:10521492
2235:14623119
2194:27094594
2143:25322456
2108:19716796
2059:20453858
2009:20601676
1964:22804352
1956:24091983
1913:22476155
1859:21532592
1807:21158740
1758:40700043
1750:16142244
1715:35042803
1707:19489725
1672:23028494
1664:24162738
1587:Genomics
1572:36212813
1492:–
1471:–
1358:interact
1306:Through
1262:Function
1140:Wikidata
809:Sources:
533:yolk sac
254:22q11.21
3707:(CDC34)
2946:Bibcode
2853:9153201
2818:9212706
2810:8563171
2780:8144544
2738:PDBe-KB
2728:UniProt
2646:Science
2631:8576257
2555:1653536
2547:9990509
2368:2613108
2185:4837539
2099:3392030
2050:2912507
1904:3411915
1850:3444301
1798:3118098
1607:9693040
1564:8672131
1494:Ensembl
1473:Ensembl
1408:TNFAIP3
1296:S phase
1230:Protein
1172:protein
942:UniProt
897:Ensembl
836:Species
815:QuickGO
724:cytosol
714:nucleus
396:pattern
122:Aliases
3751:Cullin
3040:
3005:
2976:
2966:
2923:
2894:
2886:
2851:
2816:
2808:
2778:
2733:P68036
2705:
2664:
2629:
2588:
2553:
2545:
2506:
2499:126289
2496:
2478:EMBO J
2457:
2416:
2375:
2365:
2315:
2274:
2233:
2192:
2182:
2168:: 18.
2141:
2106:
2096:
2057:
2047:
2007:
1962:
1954:
1911:
1901:
1857:
1847:
1829:Nature
1805:
1795:
1756:
1748:
1713:
1705:
1670:
1662:
1605:
1570:
1562:
1440:, and
1414:TNFSF4
1402:SMURF2
1360:with:
1342:UBE2L3
1322:, and
1248:UBCH5C
1244:lysine
1236:domain
1216:UBE2L3
1189:(RA),
1176:UBE2L3
1126:search
1124:PubMed
975:P68037
956:P68036
852:Entrez
567:BioGPS
541:embryo
513:morula
443:oocyte
170:UBE2L3
154:109240
146:603721
129:UBE2L3
22:UBE2L3
3942:ATG12
3932:FAT10
3922:NEDD8
3907:ISG15
3900:Other
3889:PIAS4
3884:PIAS3
3879:PIAS2
3874:PIAS1
3824:(UBL)
3806:BIRC6
3766:FANCL
3438:Other
3427:TRAP1
3396:Hsp90
3322:Hsp70
3211:GroEL
3207:HSP60
3202:Hsp47
3197:Hsp27
2969:27228
2892:S2CID
2814:S2CID
2551:S2CID
1960:S2CID
1754:S2CID
1711:S2CID
1668:S2CID
1568:S2CID
1444:UBOX5
1438:UBE3A
1432:UBE3A
1426:TRAF6
1420:TNIP1
1396:PARK2
1390:NEDD4
1384:CHEK1
1372:ARIH2
1366:ARIH1
1329:53BP1
1288:NF-ΞΊB
1284:c-Fos
1224:exons
885:22195
845:Mouse
840:Human
811:Amigo
419:Mouse
412:Human
359:Start
294:Mouse
258:Start
191:Human
162:43226
3957:UBL5
3947:FUB1
3937:ATG8
3917:UFM1
3912:URM1
3862:UBC9
3850:SAE2
3845:SAE1
3811:UFC1
3801:ATG3
3794:CYLD
3789:USP6
3771:UBR1
3761:MDM2
3560:SAE1
3555:NAE1
3550:ATG7
3545:UBA7
3540:UBA6
3535:UBA5
3530:UBA3
3525:UBA2
3520:UBA1
3465:SMN2
3460:SMN1
3113:1fbv
3098:1c4z
3038:PMID
3003:PMID
2974:PMID
2921:PMID
2909:1491
2884:PMID
2849:PMID
2806:PMID
2776:PMID
2726:for
2703:PMID
2662:PMID
2627:PMID
2586:PMID
2543:PMID
2504:PMID
2455:PMID
2437:Cell
2414:PMID
2373:PMID
2313:PMID
2272:PMID
2231:PMID
2190:PMID
2139:PMID
2104:PMID
2055:PMID
2005:PMID
1952:PMID
1909:PMID
1855:PMID
1803:PMID
1746:PMID
1703:PMID
1660:PMID
1603:PMID
1560:PMID
1337:NHEJ
1254:and
1214:The
1210:Gene
1179:gene
866:7332
402:Bgee
350:Band
311:Chr.
249:Band
208:Chr.
142:OMIM
99:5HPT
95:4Q5H
91:4Q5E
87:3SY2
83:3SQV
79:1FBV
75:1C4Z
56:RCSB
53:PDBe
3952:MUB
3756:CBL
3746:VHL
3739:E3
3568:E2
3513:E1
3382:12A
3313:C19
3308:C14
3303:C13
3298:C11
3293:C10
3248:B11
3028:doi
3024:277
2995:doi
2991:281
2964:PMC
2954:doi
2913:doi
2874:doi
2870:454
2839:doi
2835:272
2798:doi
2766:doi
2762:269
2724:PDB
2693:doi
2689:276
2654:doi
2650:286
2617:doi
2613:271
2578:doi
2574:415
2535:doi
2494:PMC
2486:doi
2445:doi
2441:102
2404:doi
2400:274
2363:PMC
2355:doi
2303:doi
2299:276
2262:doi
2258:274
2221:doi
2217:554
2180:PMC
2170:doi
2131:doi
2094:PMC
2086:doi
2045:PMC
2037:doi
1995:doi
1944:doi
1899:PMC
1891:doi
1845:PMC
1837:doi
1833:474
1793:PMC
1785:doi
1781:433
1738:doi
1695:doi
1652:doi
1595:doi
1552:doi
1378:CBL
1324:SLE
1280:p53
1256:His
1252:Pro
372:End
271:End
174:OMA
150:MGI
46:PDB
3985::
3782::
3726:V2
3721:V1
3711:R2
3705:R1
3700:Q2
3695:Q1
3675:L6
3670:L4
3665:L3
3660:L2
3655:L1
3645:J2
3640:J1
3625:G2
3620:G1
3615:E3
3610:E2
3605:E1
3600:D3
3595:D2
3590:D1
3422:ER
3387:14
3352:4L
3337:1L
3332:1B
3327:1A
3288:C7
3283:C6
3278:C5
3273:C3
3268:C1
3263:B9
3258:B6
3253:B4
3243:B2
3238:B1
3233:A3
3228:A2
3223:A1
3036:.
3022:.
3018:.
3001:.
2989:.
2972:.
2962:.
2952:.
2942:97
2940:.
2936:.
2919:.
2907:.
2890:.
2882:.
2868:.
2864:.
2847:.
2833:.
2829:.
2812:.
2804:.
2792:.
2774:.
2760:.
2756:.
2730::
2701:.
2687:.
2683:.
2660:.
2648:.
2625:.
2611:.
2607:.
2584:.
2572:.
2549:.
2541:.
2529:.
2516:^
2502:.
2492:.
2482:21
2480:.
2476:.
2453:.
2439:.
2435:.
2412:.
2398:.
2394:.
2371:.
2361:.
2351:20
2349:.
2345:.
2325:^
2311:.
2297:.
2293:.
2270:.
2256:.
2252:.
2229:.
2215:.
2211:.
2188:.
2178:.
2166:16
2164:.
2160:.
2137:.
2127:79
2125:.
2102:.
2092:.
2082:35
2080:.
2076:.
2053:.
2043:.
2033:17
2031:.
2027:.
2003:.
1991:19
1989:.
1985:.
1972:^
1958:.
1950:.
1940:34
1938:.
1921:^
1907:.
1897:.
1887:13
1885:.
1881:.
1867:^
1853:.
1843:.
1831:.
1827:.
1815:^
1801:.
1791:.
1779:.
1775:.
1752:.
1744:.
1734:12
1732:.
1709:.
1701:.
1691:78
1689:.
1666:.
1658:.
1648:45
1646:.
1634:^
1615:^
1601:.
1591:51
1589:.
1566:.
1558:.
1546:.
1527:.
1509:.
1480:^
1459:^
1320:CD
1318:,
1314:,
1312:RA
1298:.
1282:,
1201:.
1193:,
813:/
378:bp
365:bp
277:bp
264:bp
172:;
168::
164:;
160::
156:;
152::
148:;
144::
97:,
93:,
89:,
85:,
81:,
77:,
3928:)
3924:(
3731:Z
3716:S
3690:O
3685:N
3680:M
3650:K
3635:I
3630:H
3585:C
3580:B
3575:A
3417:Ξ²
3411:2
3409:Ξ±
3403:1
3401:Ξ±
3377:9
3372:8
3367:7
3362:6
3357:5
3347:4
3342:2
3209:/
3181:/
3167:/
3149:e
3142:t
3135:v
3073:e
3066:t
3059:v
3044:.
3030::
3009:.
2997::
2980:.
2956::
2948::
2927:.
2915::
2898:.
2876::
2855:.
2841::
2820:.
2800::
2794:6
2782:.
2768::
2740:.
2709:.
2695::
2668:.
2656::
2633:.
2619::
2592:.
2580::
2557:.
2537::
2531:3
2510:.
2488::
2461:.
2447::
2420:.
2406::
2379:.
2357::
2319:.
2305::
2278:.
2264::
2237:.
2223::
2196:.
2172::
2145:.
2133::
2110:.
2088::
2061:.
2039::
2011:.
1997::
1966:.
1946::
1915:.
1893::
1861:.
1839::
1809:.
1787::
1760:.
1740::
1717:.
1697::
1674:.
1654::
1628:.
1609:.
1597::
1574:.
1554::
1548:7
1531:.
1513:.
1446:.
1434:,
1428:,
1422:,
1416:,
1410:,
1404:,
1398:,
1392:,
1386:,
1380:,
1374:,
1368:,
296:)
193:)
176::
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